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https://www.readbyqxmd.com/read/28420302/the-genus-spirorchis-maccallum-1918-digenea-schistosomatoidea-and-the-early-history-of-parasitology-in-the-united-states
#1
Thomas Reid Platt
We know little about the founders of our discipline apart from their scientific contributions and brief biographical sketches, most frequently in published obituaries. A number of years ago, Ralph Lichtenfels, then Director of the National Parasite Collection, sent me photocopies of letters between Henry Baldwin Ward, Horace W. Stunkard, George A. MacCallum, and William G. MacCallum dating from the early years of the 20th century that hinted at a series of conflicts centered on the proposal of Spirorchis MacCallum, 1918 (Digenea: Schistosomatoidea)...
April 18, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28413380/expression-of-epidermal-growth-factor-receptor-and-transforming-growth-factor-alpha-in-cancer-bladder-schistosomal-and-non-schistosomal
#2
Afkar A Badawy, Ali El-Hindawi, Olfat Hammam, Mona Moussa, Noha S Helal, Amira Kamel
INTRODUCTION: Overexpression of epidermal growth factor receptor (EGFR) has been described in several solid tumors including bladder cancer. Transforming growth factor alpha (TGFα) is frequently deregulated in neoplastic cells and plays a role in the development of bladder cancer. TGFα-EGFR ligand-receptor combination constitutes an important event in multistep tumorigenesis. METHODS: This study was done on 30 bladder biopsies from patients with urothelial carcinoma, 15 with squamous cell carcinoma, 10 with cystitis and 5 normal control bladder specimens...
January 2017: Current Urology
https://www.readbyqxmd.com/read/28407808/nested-pcr-assay-for-detection-of-schistosoma-japonicum-infection-in-domestic-animals
#3
Xin Zhang, Chuan-Chuan He, Jin-Ming Liu, Hao Li, Ke Lu, Zhi-Qiang Fu, Chuan-Gang Zhu, Yi-Ping Liu, Lai-Bao Tong, De-Bao Zhou, Li Zha, Yang Hong, Ya-Mei Jin, Jiao-Jiao Lin
BACKGROUND: Schistosomiasis japonica is a common zoonosis. Domestic animals are the primary source of infection and play an important role in disease transmission. The prevalence and infectivity of this disease in domestic animals in China have significantly decreased and, for this reason, diagnostics with a higher sensitivity have become increasingly necessary. It was reported that polymerase chain reaction (PCR)-based methods could be used to detect schistosome infection in humans and animals and presented a high sensitivity and specificity...
April 13, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28407789/identification-and-functional-characterisation-of-a-schistosoma-japonicum-insulin-like-peptide
#4
Xiaofeng Du, Donald P McManus, Pengfei Cai, Wei Hu, Hong You
BACKGROUND: Previous studies have shown that insulin receptors in schistosomes, triggered by host insulin, play an important role in parasite growth, development and fecundity by regulating glucose metabolism. However, limited information is available on the recently identified endogenous insulin-like peptide (ILP) in blood flukes. RESULTS: We isolated ILPs from Schistosoma japonicum (SjILP) and S. recognised (SmILP) and present results of their molecular and structural analysis...
April 14, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28395189/novel-carbazole-aminoalcohols-as-inhibitors-of-%C3%AE-hematin-formation-antiplasmodial-and-antischistosomal-activities
#5
Weisi Wang, Qiang Li, Yufen Wei, Jian Xue, Xiao Sun, Yang Yu, Zhuo Chen, Shizhu Li, Liping Duan
Malaria and schistosomiasis are two of the most socioeconomically devastating parasitic diseases in tropical and subtropical countries. Since current chemotherapeutic options are limited and defective, there is an urgent need to develop novel antiplasmodials and antischistosomals. Hemozoin is a disposal product formed from the hemoglobin digestion by some blood-feeding parasites. Hemozoin formation is an essential process for the parasites to detoxify free heme, which is a reliable therapeutic target for identifying novel antiparasitic agents...
April 2, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28392476/schistosoma-mansoni-displays-an-adenine-phosphoribosyltransferase-preferentially-expressed-in-mature-female-gonads-and-vitelaria
#6
Ana Eliza Zeraik, Vitor Hugo Balasco Serrão, Larissa Romanello, Juliana Roberta Torini, Alexandre Cassago, Ricardo DeMarco, Humberto D'Muniz Pereira
Schistosoma mansoni depends upon the purine salvage pathway to obtain purine nucleotides; therefore, enzymes from this pathway are essential for parasite survival. Here, we focused on the adenine phosphoribosyltransferase (APRT) enzyme, which catalyzes the condensation reaction between adenine and PRPP (5-phosphoribosylpyrophosphate) to produce AMP and PPi. Kinetic experiments using the heterologously expressed protein of one APRT isoform from S. mansoni indicate that it is catalytically active, and whole-mount in situ hybridization studies indicate that the transcripts of this protein are concentrated in the posterior region of the ovary and vitellaria of female adult worms...
April 6, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28388965/a-novel-colloidal-gold-immunochromatography-assay-strip-for-the-diagnosis-of-schistosomiasis-japonica-in-domestic-animals
#7
Rui Xu, Jintao Feng, Yang Hong, Chao Lv, Dengyun Zhao, Jiaojiao Lin, Ke Lu, Hao Li, Jinming Liu, Xiaodan Cao, Tao Wang, Jinli Zai, Zhaozhe Wang, Bingguang Jia, Qian Han, Chuangang Zhu
BACKGROUND: Schistosomiasis remains a major public health concern in China and an epidemiological survey has revealed that schistosome-infected bovines and goats are the main transmission sources for the disease. Therefore, development of a sensitive technique for the diagnosis of schistosomiasis in domestic animals is necessary. METHOD: A novel colloidal gold immunochromatography assay (GICA) strip was developed for detecting Schistosoma japonicum in domestic animals...
April 7, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28388940/putting-the-treatment-of-paediatric-schistosomiasis-into-context
#8
REVIEW
Takafira Mduluza, Francisca Mutapi
Despite increased international efforts to control schistosomiasis using preventive chemotherapy, several challenges still exist in reaching the target populations. Until recently, preschool-aged children had been excluded from the recommended target population for mass drug administration, i.e. primary school children aged 6-15 years. Our studies and those of others provided the evidence base for the need to treat preschool-aged children that led to recommendations by the World Health Organization to include preschool-aged children in treatment programmes in 2010...
April 7, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28385494/schistosome-induced-pulmonary-b-cells-inhibit-allergic-airway-inflammation-and-display-a-reduced-th2-driving-function
#9
L E van der Vlugt, K Obieglo, A Ozir-Fazalalikhan, T Sparwasser, S Haeberlein, H H Smits
Chronic schistosome infections protect against allergic airway inflammation (AAI) via the induction of IL-10-producing splenic regulatory B (Breg) cells. Previous experiments have demonstrated that schistosome-induced pulmonary B cells can also reduce AAI, but act independently of IL-10. We have now further characterized the phenotype and inhibitory activity of these protective pulmonary B cells. We excluded a role for regulatory T (Treg) cell induction as putative AAI-protective mechanisms. Schistosome-induced B cells showed increased CD86 expression and reduced cytokine expression in response to Toll-like receptor (TLR) ligands compared with control B cells...
April 4, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28385154/efficacy-of-praziquantel-on-schistosoma-haematobium-and-re-infection-rates-among-school-going-children-in-the-ndumo-area-of-umkhanyakude-district-kwazulu-natal-south-africa
#10
Muhubiri Kabuyaya, Moses John Chimbari, Tawanda Manyangadze, Samson Mukaratirwa
BACKGROUND: Despite its low cure rates and possible resistance, praziquantel (PZQ) is the only drug available for schistosomiasis treatment. Hence, monitoring its efficacy is crucial. This study assessed the efficacy of PZQ, determined re-infection and incidence rates of Schistosoma haematobium infection among school-going children in the Ndumo area, KwaZulu-Natal. METHODS: A cohort of 320 school-going children (10 - 15 years) in 10 primary schools was screened for S...
April 7, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28384913/study-of-dickkopf-1-dkk-1-gene-expression-in-hepatocellular-carcinoma-patients
#11
Mona Watany, Rehab Badawi, Walaa Elkhalawany, Sherief Abd-Elsalam
INTRODUCTION: Hepatocellular Carcinoma (HCC) is the sixth most common cancer in the world. Dickkopf -1 (DKK-1) protein is a new biomarker used in conjunction with Alpha Fetoprotein (AFP) to differentiate HCC from "non-malignant" liver disease. DKK-1 is an inhibitor of Wnt/β-catenin signaling pathway which is involved in embryogenesis and has been implicated in tumorigenesis in many tissues. AIM: To investigate the level of DKK-1 gene expression in the peripheral blood of patients with HCC who had a history of Hepatitis C Virus (HCV) and schistosomal infections...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28376858/clinical-diagnostic-value-of-viable-schistosoma-japonicum-eggs-detected-in-host-tissues
#12
Kongzhen Gu, Yuesheng Li, Patrick Driguez, Qingren Zeng, Xinlin Yu, Hui Sun, Liting Cai, Yongkang He, Wenyang Wang, Donald P McManus
BACKGROUND: Schistosomiasis, one of the neglected tropical diseases, is endemic in more than 70 countries. However, the clinical diagnosis of patients with a low degree of infection is an unsolved technical problem. In areas endemic for schistosomiasis japonica, proctoscopy detection of eggs has been one method used for clinical diagnosis. However, it is often a challenge to find typical live eggs and it is difficult to distinguish live eggs from large numbers of partially degraded and/or completely degraded eggs within colon biopsy tissue...
April 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28362903/schistosomal-micrornas-isolated-from-extracellular-vesicles-in-sera-of-infected-patients-a-new-tool-for-diagnosis-and-follow-up-of-human-schistosomiasis
#13
Tal Meningher, Galya Lerman, Neta Regev-Rudzki, Daniel Gold, Iddo Z Ben-Dov, Yechezkel Sidi, Dror Avni, Eli Schwartz
Background: Schistosomiasis traditionally has been diagnosed by detecting eggs in stool or urine. However, the sensitivity of these examinations is limited, especially in travelers with a low worm burden. Serologic tests have a greater sensitivity, but their results remain positive regardless of treatment and thus cannot be used for follow-up of patients. We hypothesized that detection of worm microRNAs (miRNAs) in serum can overcome the drawbacks of the existing diagnostic methods. Methods and Results: Twenty-six returning travelers with schistosomiasis (based on positive results of serologic tests or detection of ova) and 17 healthy controls were included in the study...
February 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28352943/function-of-nanos1-gene-in-the-development-of-reproductive-organs-of-schistosoma-japonicum
#14
Quan Liu, Lulu Zhu, Fengchun Liu, Mengqing Hua, Han Ding, Siyu He, Cuiping Ren, Miao Liu, Jijia Shen
Nanos is a necessary factor in the differentiation and migration of primordial germ cells. It is closely associated with the development of genitalia in a wide range of species. We questioned whether Nanos was involved in the reproductive organ development of Schistosoma japonicum. Firstly, by in situ hybridization, S. japonicum Nanos1 (SjNanos1) gene was expressed mainly in reproductive organs of S. japonicum. Then, the paired schistosome of 28 days post-infection (dpi) was transfected with SjNanos1 small interfering RNA three times and cultured in vitro for 10 days...
March 28, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28348881/in-vitro-assessment-of-anthelmintic-activities-of-rauwolfia-vomitoria-apocynaceae-stem-bark-and-roots-against-parasitic-stages-of-schistosoma-mansoni-and-cytotoxic-study
#15
Emmanuel Mouafo Tekwu, Kwabena Mante Bosompem, William Kofi Anyan, Regina Appiah-Opong, Kofi Baffour-Awuah Owusu, Mabel Deladem Tettey, Felicia Amanfo Kissi, Alfred Ampomah Appiah, Veronique Penlap Beng, Alexander Kwadwo Nyarko
Schistosomiasis is a Neglected Tropical Diseases which can be prevented with mass deworming chemotherapy. The reliance on a single drug, praziquantel, is a motivation for the search of novel antischistosomal compounds. This study investigated the anthelmintic activity of the stem bark and roots of Rauwolfia vomitoria against two life stages of Schistosoma mansoni. Both plant parts were found to be active against cercariae and adult worms. Within 2 h of exposure all cercariae were killed at a concentration range of 62...
2017: Journal of Parasitology Research
https://www.readbyqxmd.com/read/28347672/structural-and-kinetic-analysis-of-schistosoma-mansoni-adenylosuccinate-lyase-smadsl
#16
Larissa Romanello, Vitor Hugo Balasco Serrão, Juliana Roberta Torini, Louise E Bird, Joanne E Nettleship, Heather Rada, Yamini Reddivari, Ray J Owens, Ricardo DeMarco, José Brandão-Neto, Humberto D'Muniz Pereira
Schistosoma mansoni is the parasite responsible for schistosomiasis, a disease that affects about 218 million people worldwide. Currently, both direct treatment and disease control initiatives rely on chemotherapy using a single drug, praziquantel. Concerns over the possibility of resistance developing to praziquantel, have stimulated efforts to develop new drugs for the treatment of schistosomiasis. Schistosomes do not have the de novo purine biosynthetic pathway, and instead depend entirely on the purine salvage pathway to supply its need for purines...
March 25, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28346516/protective-immune-responses-against-schistosoma-mansoni-infection-by-immunization-with-functionally-active-gut-derived-cysteine-peptidases-alone-and-in-combination-with-glyceraldehyde-3-phosphate-dehydrogenase
#17
Hatem Tallima, Jan Dvořák, Sahira Kareem, Marwa Abou El Dahab, Nada Abdel Aziz, John Pius Dalton, Rashika El Ridi
BACKGROUND: Schistosomiasis, a severe disease caused by parasites of the genus Schistosoma, is prevalent in 74 countries, affecting more than 250 million people, particularly children. We have previously shown that the Schistosoma mansoni gut-derived cysteine peptidase, cathepsin B1 (SmCB1), administered without adjuvant, elicits protection (>60%) against challenge infection of S. mansoni or S. haematobium in outbred, CD-1 mice. Here we compare the immunogenicity and protective potential of another gut-derived cysteine peptidase, S...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28336269/epidemiology-of-polyparasitism-with-taenia-solium-schistosomes-and-soil-transmitted-helminths-in-the-co-endemic-village-of-malanga-democratic-republic-of-congo
#18
Joule Madinga, Katja Polman, Kirezi Kanobana, Lisette van Lieshout, Eric Brienen, Nicolas Praet, Constantin Kabwe, Sarah Gabriël, Pierre Dorny, Pascal Lutumba, Niko Speybroeck
Helminth co-infections are common in sub-Saharan Africa. However, little is known about the distribution and determinants of co-infections with Taenia solium taeniasis/cysticercosis. Building on a previous community-based study on human cysticercosis in Malanga village, we investigated co-infections with Taenia solium, soil-transmitted helminths (STHs) and Schistosoma spp and associated risk factors in a random subsample of 330 participants. Real time PCR assays were used to detect DNA of soil-transmitted helminths (STHs), T...
March 20, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28335010/schistosomiasis-in-scottish-travellers-public-health-importance-of-laboratory-testing-and-the-need-for-enhanced-surveillance
#19
Claire L Alexander, Laura Cottom, Kitty Smith, Kali Perrow, Michael Coyne, Brian L Jones
Background: Imported schistosomiasis is of significant public health importance and is likely to be underestimated since infection is often asymptomatic. We describe data from travellers residing in Scotland which includes a subset of group travellers from one of the largest Health Boards in Scotland. Methods: Clotted bloods were obtained during the period 2001-15 from a total of 8163 Scottish travellers. This included seven groups comprising of 182 travellers. Sera were examined for the presence of Schistosome species antibody at the Scottish Parasite Diagnostic and Reference Laboratory (SPDRL)...
March 14, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28331224/enhanced-wnt-signalling-in-hepatocytes-is-associated-with-schistosoma-japonicum-infection-and-contributes-to-liver-fibrosis
#20
Qi Wang, Xin Chou, Fei Guan, Zhengming Fang, Shengjun Lu, Jiahui Lei, Yonglong Li, Wenqi Liu
Liver fibrosis is the most serious pathology caused by Schistosoma japonicum infection, which arises when schistosome eggs are deposited in the liver. Eosinophils, macrophages and hepatic stellate cells (HSCs) have been identified as major cellular contributors to the development of granulomas and fibrosis, but little is known about the effects of hepatocytes on granuloma formation. Here, we found that the levels of Wnt signalling-related molecules, transforming growth factor β (TGF-β) and connective tissue growth factor (CTGF) in hepatocytes were markedly elevated after S...
March 22, 2017: Scientific Reports
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