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https://www.readbyqxmd.com/read/28336269/epidemiology-of-polyparasitism-with-taenia-solium-schistosomes-and-soil-transmitted-helminths-in-the-co-endemic-village-of-malanga-democratic-republic-of-congo
#1
Joule Madinga, Katja Polman, Kirezi Kanobana, Lisette van Lieshout, Eric Brienen, Nicolas Praet, Constantin Kabwe, Sarah Gabriël, Pierre Dorny, Pascal Lutumba, Niko Speybroeck
Helminth co-infections are common in sub-Saharan Africa. However, little is known about the distribution and determinants of co-infections with Taenia solium taeniasis/cysticercosis. Building on a previous community-based study on human cysticercosis in Malanga village, we investigated co-infections with Taenia solium, soil-transmitted helminths (STHs) and Schistosoma spp and associated risk factors in a random subsample of 330 participants. Real time PCR assays were used to detect DNA of soil-transmitted helminths (STHs), T...
March 20, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28335010/schistosomiasis-in-scottish-travellers-public-health-importance-of-laboratory-testing-and-the-need-for-enhanced-surveillance
#2
Claire L Alexander, Laura Cottom, Kitty Smith, Kali Perrow, Michael Coyne, Brian L Jones
Background: Imported schistosomiasis is of significant public health importance and is likely to be underestimated since infection is often asymptomatic. We describe data from travellers residing in Scotland which includes a subset of group travellers from one of the largest Health Boards in Scotland. Methods: Clotted bloods were obtained during the period 2001-15 from a total of 8163 Scottish travellers. This included seven groups comprising of 182 travellers. Sera were examined for the presence of Schistosome species antibody at the Scottish Parasite Diagnostic and Reference Laboratory (SPDRL)...
March 14, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28331224/enhanced-wnt-signalling-in-hepatocytes-is-associated-with-schistosoma-japonicum-infection-and-contributes-to-liver-fibrosis
#3
Qi Wang, Xin Chou, Fei Guan, Zhengming Fang, Shengjun Lu, Jiahui Lei, Yonglong Li, Wenqi Liu
Liver fibrosis is the most serious pathology caused by Schistosoma japonicum infection, which arises when schistosome eggs are deposited in the liver. Eosinophils, macrophages and hepatic stellate cells (HSCs) have been identified as major cellular contributors to the development of granulomas and fibrosis, but little is known about the effects of hepatocytes on granuloma formation. Here, we found that the levels of Wnt signalling-related molecules, transforming growth factor β (TGF-β) and connective tissue growth factor (CTGF) in hepatocytes were markedly elevated after S...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327785/ultrastructural-alterations-in-schistosoma-mansoni-juvenile-and-adult-male-worms-after-in-vitro-incubation-with-primaquine
#4
Reem Osama A Kamel, Fatma El-Zahraa Anwar Bayaumy
BACKGROUND: Praziquantel has been cited as the only drug for treating schistosomiasis. However, concerns over drug resistance have encouraged the search for novel drug leads. The antimalarial drug primaquine possesses interesting anti-schistosmal properties. OBJECTIVES: This study is the first to document the potential role of primaquine as a schistosomicide and the ultrastructural changes induced by primaquine on juvenile or adult male worms of Schistosoma mansoni...
April 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28327187/schistosomiasis-is-more-prevalent-than-previously-thought-what-does-it-mean-for-public-health-goals-policies-strategies-guidelines-and-intervention-programs
#5
REVIEW
Daniel G Colley, Tamara S Andros, Carl H Campbell
Mapping and diagnosis of infections by the three major schistosome species (Schistosoma haematobium, S. mansoni and S. japonicum) has been done with assays that are known to be specific but increasingly insensitive as prevalence declines or in areas with already low prevalence of infection. This becomes a true challenge to achieving the goal of elimination of schistosomiasis because the multiplicative portion of the life-cycle of schistosomes, in the snail vector, favors continued transmission as long as even a few people maintain low numbers of worms that pass eggs in their excreta...
March 22, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28325369/the-compatibility-between-biomphalaria-glabrata-snails-and-schistosoma-mansoni-an-increasingly-complex-puzzle
#6
G Mitta, B Gourbal, C Grunau, M Knight, J M Bridger, A Théron
This review reexamines the results obtained in recent decades regarding the compatibility polymorphism between the snail, Biomphalaria glabrata, and the pathogen, Schistosoma mansoni, which is one of the agents responsible for human schistosomiasis. Some results point to the snail's resistance as explaining the incompatibility, while others support a "matching hypothesis" between the snail's immune receptors and the schistosome's antigens. We propose here that the two hypotheses are not exclusive, and that the compatible/incompatible status of a particular host/parasite couple probably reflects the balance of multiple molecular determinants that support one hypothesis or the other...
2017: Advances in Parasitology
https://www.readbyqxmd.com/read/28322847/identification-and-functional-characterization-of-oncomelania-hupensis-macrophage-migration-inhibitory-factor-involved-in-the-snail-host-innate-immune-response-to-the-parasite-schistosoma-japonicum
#7
Shuaiqin Huang, Yunchao Cao, Mingke Lu, Wenfeng Peng, Jiaojiao Lin, Chongti Tang, Liang Tang
Schistosomiasis, caused by parasitic trematodes of the genus Schistosoma, remains a devastating public health problem, with over 200 million people infected and 779 million people at risk worldwide, especially in developing countries. The freshwater amphibious snail Oncomelania hupensis is the obligate intermediate host of Schistosoma japonicum. This unique and long-standing host-parasite interaction highlights the biomedical importance of the molecular and cellular mechanisms involved in the snail immune defense response against schistosome infection...
March 18, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28319196/h-channels-in-embryonic-biomphalaria-glabrata-cell-membranes-putative-roles-in-snail-host-schistosome-interactions
#8
Brandon J Wright, Utibe Bickham-Wright, Timothy P Yoshino, Meyer B Jackson
The human blood fluke Schistosoma mansoni causes intestinal schistosomiasis, a widespread neglected tropical disease. Infection of freshwater snails Biomphalaria spp. is an essential step in the transmission of S. mansoni to humans, although the physiological interactions between the parasite and its obligate snail host that determine success or failure are still poorly understood. In the present study, the B. glabrata embryonic (Bge) cell line, a widely used in vitro model for hemocyte-like activity, was used to investigate membrane properties, and assess the impact of larval transformation proteins (LTP) on identified ion channels...
March 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28316416/murine-hepatocytes-dna-changes-as-an-assessment-of-the-immunogenicity-of-potential-anti-schistosomal-vaccines-experimentally
#9
Samia E Etewa, Mohamed H A Hegab, Ashraf S Metwally, Somia H Abd Allah, Sally M Shalaby, Amal S El-Shal, Mohamed Baredy, Mahmoud A El Shafey, Howayda S F Moawad
Hepatic affection by granulomatous inflammation in schistosomiasis suggested that a potential anti-pathology vaccine could be generated based on limiting the presence of hazardous hepatocytes induced apoptosis and caused reduction of granulomas number and size . So, this work is concerned with experimental assessment of the efficacy of different Schistosoma mansoni antigens (SEA, SWAP and combined SEA and SWAP) on murine liver after challenge by Schistosoma infection, histopathological, histochemical and molecular investigations were performed on sixty male laboratory bred Swiss Albino mice...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28296924/changes-in-surface-glycosylation-and-glycocalyx-shedding-in-trichobilharzia-regenti-schistosomatidae-during-the-transformation-of-cercaria-to-schistosomulum
#10
Jana Řimnáčová, Libor Mikeš, Libuše Turjanicová, Jana Bulantová, Petr Horák
The invasive larvae (cercariae) of schistosomes penetrate the skin of their definitive hosts. During the invasion, they undergo dramatic ultrastructural and physiological transitions. These changes result in the development of the subsequent stage, schistosomulum, which migrates through host tissues in close contact with host's immune system. One of the striking changes in the transforming cercariae is the shedding of their thick tegumental glycocalyx, which represents an immunoattractive structure; therefore its removal helps cercariae to avoid immune attack...
2017: PloS One
https://www.readbyqxmd.com/read/28287085/dynamic-transcriptomes-identify-biogenic-amines-and-insect-like-hormonal-regulation-for-mediating-reproduction-in-schistosoma-japonicum
#11
Jipeng Wang, Ying Yu, Haimo Shen, Tao Qing, Yuanting Zheng, Qing Li, Xiaojin Mo, Shuqi Wang, Nana Li, Riyi Chai, Bin Xu, Mu Liu, Paul J Brindley, Donald P McManus, Zheng Feng, Leming Shi, Wei Hu
Eggs produced by the mature female parasite are responsible for the pathogenesis and transmission of schistosomiasis. Female schistosomes rely on a unique male-induced strategy to accomplish reproductive development, a process that is incompletely understood. Here we map detailed transcriptomic profiles of male and female Schistosoma japonicum across eight time points throughout the sexual developmental process from pairing to maturation. The dynamic gene expression pattern data reveal clear sex-related characteristics, indicative of an unambiguous functional division between males and females during their interplay...
March 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28279453/a-comparison-of-two-mathematical-models-of-the-impact-of-mass-drug-administration-on-the-transmission-and-control-of-schistosomiasis
#12
J E Truscott, D Gurarie, R Alsallaq, J Toor, N Yoon, S H Farrell, H C Turner, A E Phillips, H O Aurelio, J Ferro, C H King, R M Anderson
The predictions of two mathematical models describing the transmission dynamics of schistosome infection and the impact of mass drug administration are compared. The models differ in their description of the dynamics of the parasites within the host population and in their representation of the stages of the parasite lifecycle outside of the host. Key parameters are estimated from data collected in northern Mozambique from 2011 to 2015. This type of data set is valuable for model validation as treatment prior to the study was minimal...
March 2017: Epidemics
https://www.readbyqxmd.com/read/28271497/chronic-schistosomiasis-during-pregnancy-epigenetically-reprograms-t-cell-differentiation-in-offspring-of-infected-mothers
#13
Kathrin Klar, Sophie Perchermeier, Sonakshi Bhattacharjee, Hani Harb, Thure Adler, Rouzanna Istvanffy, Eva Loffredo-Verde, Robert Oostendorp, Harald Renz, Clarissa Prazeres da Costa
Schistosomiasis is a non-transplacental helminth infection. Chronic infection during pregnancy suppresses allergic airway responses in offspring. We addressed the question whether in utero exposure to chronic schistosome infection (Reg phase) in mice affects B cell and T cell development. Therefore, we focused our analysis on T cell differentiation capacity induced by epigenetic changes in promoter regions of signature cytokines in offspring. Here we show that naïve T cells from offspring of schistosome infected female mice had a strong capacity to differentiate into TH 1 cells, whereas TH 2 differentiation was impaired...
March 8, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28264841/praziquantel-for-schistosomiasis-single-drug-revisited-metabolism-mode-of-action-and-resistance
#14
Nuno Vale, Maria João Gouveia, Gabriel Rinaldi, Paul J Brindley, Fátima Gärtner, José M C Correia da Costa
Schistosomiasis, a major neglected tropical disease, affects more than 250 million people worldwide. Treatment for schistosomiasis has relied on the anthelmintic drug praziquantel (PZQ) for more than a generation. PZQ is the drug of choice for treatment of schistosomiasis; it is effective against all major forms of schistosomiasis, although PZQ is less active against juvenile compared to mature parasites. A pyrazino-isoquinoline derivative, PZQ is not considered to be toxic and generally causes few or transient, mild side effects...
March 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28264699/recent-range-expansion-of-an-intermediate-host-for-animal-schistosome-parasites-in-the-indo-australian-archipelago-phylogeography-of-the-freshwater-gastropod-indoplanorbis-exustus-in-south-and-southeast-asia
#15
Pauline Gauffre-Autelin, Thomas von Rintelen, Björn Stelbrink, Christian Albrecht
BACKGROUND: The planorbid snail Indoplanorbis exustus is the sole intermediate host for the Schistosoma indicum species group, trematode parasites responsible for cattle schistosomiasis and human cercarial dermatitis. This freshwater snail is widely distributed in Southern Asia, ranging from Iran to China eastwards including India and from the southeastern Himalayas to Southeast Asia southwards. The veterinary and medical importance of this snail explains the interest in understanding its geographical distribution patterns and evolutionary history...
March 6, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28257854/integrated-multi-omic-analyses-in-biomphalaria-schistosoma-dialogue-reveal-the-immunobiological-significance-of-frep-smpomuc-interaction
#16
Anaïs Portet, Silvain Pinaud, Guillaume Tetreau, Richard Galinier, Céline Cosseau, David Duval, Christoph Grunau, Guillaume Mitta, Benjamin Gourbal
The fresh water snail Biomphalaria glabrata is one of the vectors of the trematode pathogen Schistosoma mansoni, which is one of the agents responsible of human schistosomiasis. In this host-parasite interaction, co-evolutionary dynamic results into an infectivity mosaic known as compatibility polymorphism. Integrative approaches including large scale molecular approaches have been conducted in recent years to improve our understanding of the mechanisms underlying compatibility. This review presents the combination of integrated Multi-Omic approaches leading to the discovery of two repertoires of polymorphic and/or diversified interacting molecules: the parasite antigens S...
February 28, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28253264/a-multistrain-approach-to-studying-the-mechanisms-underlying-compatibility-in-the-interaction-between-biomphalaria-glabrata-and-schistosoma-mansoni
#17
Richard Galinier, Emmanuel Roger, Yves Moné, David Duval, Anaïs Portet, Silvain Pinaud, Cristian Chaparro, Christoph Grunau, Clémence Genthon, Emeric Dubois, Anne Rognon, Nathalie Arancibia, Bernard Dejean, André Théron, Benjamin Gourbal, Guillaume Mitta
In recent decades, numerous studies have sought to better understand the mechanisms underlying the compatibility between Biomphalaria glabrata and Schistosoma mansoni. The developments of comparative transcriptomics, comparative genomics, interactomics and more targeted approaches have enabled researchers to identify a series of candidate genes. However, no molecular comparative work has yet been performed on multiple populations displaying different levels of compatibility. Here, we seek to fill this gap in the literature...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28238285/urogenital-schistosomiasis-and-soil-transmitted-helminthiasis-sth-in-cameroon-an-epidemiological-update-at-barombi-mbo-and-barombi-kotto-crater-lakes-assessing-prospects-for-intensified-control-interventions
#18
Suzy J Campbell, J Russell Stothard, Faye O'Halloran, Deborah Sankey, Timothy Durant, Dieudonné Eloundou Ombede, Gwladys Djomkam Chuinteu, Bonnie L Webster, Lucas Cunningham, E James LaCourse, Louis-Albert Tchuem-Tchuenté
BACKGROUND: The crater lakes of Barombi Mbo and Barombi Kotto are well-known transmission foci of schistosomiasis and soil-transmitted helminthiasis having had several important control initiatives previously. To collect contemporary epidemiological information, a cross-sectional survey was undertaken inclusive of: signs and symptoms of disease, individual treatment histories, local water, sanitation and hygiene (WASH)-related factors and malacological surveillance, with molecular characterisation of specimens...
February 27, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28216728/marine-and-other-aquatic-dermatoses
#19
Surg Capt Jandhyala Sridhar, Surg Cdr Rajeev Deo
Occupational and recreational aquatic activity predisposes our population to a wide variety of dermatoses. Sunburn, urticaria, jellyfish stings, and contact dermatitis to rubber equipment are common allergies that are encountered in the aquatic environment. Among the infections, tinea versicolor, intertrigo, and verruca vulgaris are widespread. Swimmer's itch may occur due to skin penetration by schistosome cercariae, while free-floating nematocysts of marine coelenterates may precipitate seabather's eruption...
January 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28215207/detecting-hybridization-in-african-schistosome-species-does-egg-morphology-complement-molecular-species-identification
#20
Nele A M Boon, Wouter Fannes, Sara Rombouts, Katja Polman, Filip A M Volckaert, Tine Huyse
Hybrid parasites may have an increased transmission potential and higher virulence compared to their parental species. Consequently, hybrid detection is critical for disease control. Previous crossing experiments showed that hybrid schistosome eggs have distinct morphotypes. We therefore compared the performance of egg morphology with molecular markers with regard to detecting hybridization in schistosomes. We studied the morphology of 303 terminal-spined eggs, originating from 19 individuals inhabiting a hybrid zone with natural crosses between the human parasite Schistosoma haematobium and the livestock parasite Schistosoma bovis in Senegal...
February 20, 2017: Parasitology
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