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Qiang Wang, Akram A Da'dara, Patrick J Skelly
BACKGROUND: Schistosomes are blood dwelling parasitic worms that cause the debilitating disease schistosomiasis. Here we examined the influence of the parasites on their external environment by monitoring the impact of adult Schistosoma mansoni worms on the murine plasma proteome in vitro and, in particular, on how the worms affect the blood coagulation protein high molecular weight kininogen (HK). METHODS: Following the incubation of adult schistosomes in murine plasma, two-dimensional differential in-gel electrophoresis (2D-DIGE) was conducted to look for changes in the plasma proteome compared with control plasma...
March 14, 2018: Parasites & Vectors
Ya Yang, Jianchuan Gao, Wanting Cheng, Xiang Pan, Yu Yang, Yue Chen, Qingqing Dai, Lan Zhu, Yibiao Zhou, Qingwu Jiang
BACKGROUND: Schistosomiasis remains a major public health concern in China. Oncomelania hupensis (O. hupensis) is the sole intermediate host of Schistosoma japonicum, and its change in distribution and density influences the endemic S. japonicum. The Three Gorges Dam (TGD) has substantially changed the downstream water levels of the dam. This study investigated the quantitative relationship between flooding duration and the density of the snail population. METHODS: Two bottomlands without any control measures for snails were selected in Yueyang City, Hunan Province...
March 14, 2018: Parasites & Vectors
Deng Ji-Guang, Yu Shui-Lan, Nong Zhi, Jiang Zhi-Hua
OBJECTIVE: To evaluate the monitoring results of medium- and long-term program of schistosomiasis control in Baise City, so as to provide the reference for the elimination of schistosomiasis. METHODS: The data of schistosomiasis control in Baise City from 2004 to 2015 were collected and analyzed. RESULTS: By the end of 2015, the total number of regular screening serum tests for schistosomiasis in the planning period was 10 244 person-times, with 649 positive cases...
December 7, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Gao Yuan, Yang Pei-Cai, Yang Su, Xu Fei
OBJECTIVE: To develop a dynamic automatic identification system (device) of Schistosoma japonicum miracidia to achieve the automatic detection and improve the detection rate and efficiency of schistosome miracidia. METHODS: The dynamic automatic identification system (device) of S.japonicum miracidia was composed of an optical stereoscope, a digital camera, dynamic automatic tracking recognition software, and a computer. Under different conditions, the detection rates and efficiency of the system were compared with those of five professional persons...
February 24, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Hu He-Hua, Zhang Xia, Zhang Chun-Bin, Yao Yi-Bin, Cui Cai-Xia, Li Xia, Wen Xiao-Hong, Liu Jun, Xiao Chuan-Yun, Liu Xiong, Cao Chun-Li
OBJECTIVE: To investigate the changes of serum anti-schistosome antibody titers in schistosomiasis japonica patients after treatment, in order to provide the evidence for formulating the schistosomiasis surveillance program in marshland and lake regions. METHODS: Upon prospective cohort study, the stool examination positive schistosomiasis patients and blood examination positive suspected patients (the titer was more than 1:80, including 1:80) were selected as the research objects in Jiangling County in 2014, and they received the 2-day praziquantel therapy...
January 15, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Yang Ya, Li Jian-Bing, Liu Hao, Li Shi-Gui, He Zhong, Cai Bin, Li Lin-Han, Cheng Wan-Ting, Yang Yu, Zhou Jie, Li Zhi-Yang, Ren Guang-Hui, Luo Zhi-Hong, Zhou Yi-Biao, Jiang Qing-Wu
OBJECTIVE: To evaluate the cost-effectiveness of comprehensive schistosomiasis control measures with focus on total removal of cattle and sheep in Juanshan District, Yueyang City. METHODS: The schistosome infection status of human, cattle, sheep and Oncomelania hupensis snails and costs of control measures were gathered during the period of 2006 to 2016. The costs for different periods and cost-effectiveness ratios were calculated. RESULTS: The prevalence of schistosome infection in residents in the pilot villages decreased from 3...
December 26, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Jack P Carson, Grant A Ramm, Mark W Robinson, Donald P McManus, Geoffrey N Gobert
Hepatic fibrosis is a common pathology in various liver diseases. Hepatic stellate cells (HSCs) are the main cell type responsible for collagen deposition and fibrosis formation in the liver. Schistosomiasis is characterised by granulomatous fibrosis around parasite eggs trapped within the liver and other host tissues. This response is facilitated by the recruitment of immune cells and the activation of HSCs. The interactions between HSCs and schistosome eggs are complex and diverse, and a better understanding of these interactions could lead to improved resolution of fibrotic liver disease, including that associated with schistosomiasis...
March 8, 2018: Trends in Parasitology
Catieli Gobetti Lindholz, Vivian Favero, Carolina de Marco Verissimo, Renata Russo Frasca Candido, Renata Perotto de Souza, Renata Rosa Dos Santos, Alessandra Loureiro Morassutti, Helio Radke Bittencourt, Malcolm K Jones, Timothy G St Pierre, Carlos Graeff-Teixeira
Control initiatives have successfully reduced the prevalence and intensity of schistosomiasis transmission in several localities around the world. However, individuals that release low numbers of eggs in their feces may not be detected by classical methods that are limited by low sensitivity. Given that accurate estimates of prevalence are key to implementing planning control actions for the elimination of schistosomiasis, new diagnostic tools are needed to effectively monitor infections and confirm transmission interruption...
March 2018: PLoS Neglected Tropical Diseases
Joseph E Igetei, Marwa El-Faham, Susan Liddell, Gabriele Schramm, Michael J Doenhoff
Previous studies have shown that schistosome infection can protect against allergic symptoms, but the underlying mechanisms are still not fully understood. Here we have shown that rabbit IgG antibodies raised against Schistosoma mansoni soluble egg antigens (SmSEA) are cross-reactive with a wide array of molecules in Timothy grass pollen (TGP) and birch tree pollen (BTP). Five of the cross-reactive pollen molecules (two from TGP and three from BTP) were selected randomly and identified by tandem mass spectrometric (TMS) analysis to be, respectively, the TGP allergens Phl p 1 and Phl p 5b, and BTP glutathione S-transferase (GST), and the BTP allergens Bet v 1 and Bet v 6...
March 3, 2018: International Journal for Parasitology
H E Ming-Zhen, X Yi-Qing, C Hong, Z Yong-Gen, Z Shi-Ying, G Yan-Li
Objective To analyze the Oncomelania hupensis snail distribution and the changes of snail situation in Changzhou City from 2013 to 2016, so as to provide the evidence for formulating the schistosomiasis prevention and control interventions. Methods The data of snail monitoring in Changzhou City from 2013 to 2016 were collected and statistically analyzed. Results The total area with snails was 40.17 hm2 and the newly discovered area was 30.63 hm2 in Changzhou City from 2013 to 2016. In the four years, 3 454 snails were dissected, and no schistosome infected snails were found...
April 27, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
X I Xing-Wang
Objective To analyze the epidemic situation of schistosomiasis in Wuhu County from 2012 to 2016, so as to provide the reference for adjusting the control strategy. Methods The data of schistosomiasis prevention and control in Wuhu County from 2012 to 2016 were collected and longitudinally analyzed. Results Since 2013, the average infection rate of schistosomiasis in the population decreased year by year, and the infection rate decreased to 0 in 2016. Since 2012, the infection rate of livestock was 0. The area with Oncomelania hupensis snails decreased year by year, but it drastically rebounded in 2016...
August 14, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
L I Guo, C Yan-Yan, T U Zhen, S Xiao-Wei, C Shun-Xiang
Objective To investigate the water infectivity in key water regions, and analyze the transmission risk of schistosomiasis in suspicious and high-risk environments in Hubei Province in 2016. Methods Schistosome-endemic areas of the Yangtze River, the Hanbei River and the Fu River were chosen as the surveillance and forecast sites. The water infectivity was detected by using the sentinel mice during the flood season. The infection status of residents in the villages around the surveillance sites and the activities of human beings and domestic animals were surveyed...
July 27, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
H U Ben-Jiao, Z Zheng-Yuan, X Meng, L I Guang-Ping, R Guang-Hui, J Qing-Wu, Z Yi-Biao
Objective To explore the spatial-temporal characteristics and changing regularities of Schistosoma japonicum infections among human from 2004 to 2011. Methods The township level spatial databases of schistosomiasis in Hunan Province from 2004 to 2011 were established, and the related spatial analysis was performed by SPSS 17.0, ArcGIS 10.1 and SaTScan 7.03. Results The schistosome infection rate among human in Hunan Province sharply decreased from 3.0% in 2004 to 0.8% in 2011. However, the rate among residents in parts of some townships in 2011 was still hovering at a higher level ( P 90 = 2...
July 24, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
L I Wen-Bin, Y Ya, P Xiang, L I Jian-Bing, L Hui-Xiang, L I Shi-Gui, H E Zhong, C Bin, L I Lin-Han, C Wan-Ting, Y Yu, Z Jie, L I Sheng-Ming, R Guang-Hui, L Zhi-Hong, Z Yi-Biao, J Qing-Wu
Objective To evaluate the effect of comprehensive schistosomiasis control measures with focus on total removal of cattle and sheep in Junshan District, Yueyang City. Methods The retrospective review and field survey were implemented in the pilot villages in Junshan District. The data of Schistosoma japonicum infection status of human, cattle, sheep and Oncomelania hupensis snails, and density of snails were gathered and modeled in the period of 2006 to 2016. Results The prevalence of schistosome infection in residents in the pilot villages decreased from 3...
August 15, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Paul Ogongo, Thomas M Kariuki, R Alan Wilson
The inadequacy of current diagnostics for the detection of low worm burdens in humans means that schistosomiasis mansoni is more widespread than previously acknowledged. With the inception of mass drug treatment programmes aimed at disease elimination and the advent of human vaccine trials, the need for more sensitive diagnostics is evident. In this review, we evaluate the merits and limitations of the principal diagnostic methods, namely detection of eggs in faeces; anti-schistosome antibodies in serum; parasite-derived proteins and glycans in serum or urine; parasite DNA in blood, faeces or urine...
March 6, 2018: Parasitology
M Golam Yasin, Md Abdul Alim, Syed Ali Ahasan, Md Nuruzzaman Munsi, Emdadul Haque Chowdhury, Takeshi Hatta, Naotoshi Tsuji, Md Motahar Hussain Mondal
The prevalence of snail-borne trematode (SBT) infections in farm animals on the offshore Saint (St.) Martin's Island of Bangladesh were 68.9% for cattle, 76.7% for buffaloes, 56.3% for goats, respectively. Examination of fecal samples showed that paramphistomes infection was the most common at 50.5% followed by schistosomes at 23.7% and Fasciola at 2.3%. Fasciola infection was found in cattle (1.9%) and buffaloes (16.7%) but not in goats. Schistosome infection in cattle, buffaloes and goats were 31.1%, 6.7% and 17...
March 5, 2018: Journal of Veterinary Medical Science
Da-Bing Lu, Yao Deng, Huan Ding, You-Sheng Liang, Joanne P Webster
No abstract text is available yet for this article.
March 2018: PLoS Pathogens
Gabriel Mouahid, Anne Rognon, Ronaldo de Carvalho Augusto, Patrick Driguez, Kathy Geyer, Shannon Karinshak, Nelia Luviano, Victoria Mann, Thomas Quack, Kate Rawlinson, George Wendt, Christoph Grunau, Hélène Moné
Schistosomiasis is an important parasitic disease, touching roughly 200 million people worldwide. The causative agents are different Schistosoma species. Schistosomes have a complex life cycle, with a freshwater snail as intermediate host. After infection, sporocysts develop inside the snail host and give rise to human dwelling larvae. We present here a detailed step-by-step video instruction in English, French, Spanish and Portuguese that shows how these sporocysts can be manipulated and transferred from one snail to another...
2018: Wellcome Open Research
Neal T Halstead, Christopher M Hoover, Arathi Arakala, David J Civitello, Giulio A De Leo, Manoj Gambhir, Steve A Johnson, Nicolas Jouanard, Kristin A Loerns, Taegan A McMahon, Raphael A Ndione, Karena Nguyen, Thomas R Raffel, Justin V Remais, Gilles Riveau, Susanne H Sokolow, Jason R Rohr
Schistosomiasis is a snail-borne parasitic disease that ranks among the most important water-based diseases of humans in developing countries. Increased prevalence and spread of human schistosomiasis to non-endemic areas has been consistently linked with water resource management related to agricultural expansion. However, the role of agrochemical pollution in human schistosome transmission remains unexplored, despite strong evidence of agrochemicals increasing snail-borne diseases of wildlife and a projected 2- to 5-fold increase in global agrochemical use by 2050...
February 26, 2018: Nature Communications
Jan Dvořák, Martin Horn
Trematodes, also known as flukes, are phylogenetically ancient parasitic organisms. Due to their importance as human and veterinary parasites, their proteins have been investigated extensively as drug and vaccine targets. Among those, proteases, as crucial enzymes for parasite survival, are considered candidate molecules for anti-parasitic interventions. Surprisingly however, trematode serine proteases, in comparison with other groups of proteases, are largely neglected. Genes encoding serine proteases have been identified in trematode genomes in significant abundance, but the biological roles and biochemical functions of these proteases are poorly understood...
February 22, 2018: International Journal for Parasitology
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