keyword
MENU ▼
Read by QxMD icon Read
search

Schistosome

keyword
https://www.readbyqxmd.com/read/28098789/implications-of-changing-temperatures-on-the-growth-fecundity-and-survival-of-intermediate-host-snails-of-schistosomiasis-a-systematic-review
#1
REVIEW
Chester Kalinda, Moses Chimbari, Samson Mukaratirwa
Climate change has been predicted to increase the global mean temperature and to alter the ecological interactions among organisms. These changes may play critical roles in influencing the life history traits of the intermediate hosts (IHs). This review focused on studies and disease models that evaluate the potential effect of temperature rise on the ecology of IH snails and the development of parasites within them. The main focus was on IH snails of schistosome parasites that cause schistosomiasis in humans...
January 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28095417/schistosoma-mansoni-infection-of-mice-rats-and-humans-elicits-a-strong-antibody-response-to-a-limited-number-of-reduction-sensitive-epitopes-on-five-major-tegumental-membrane-proteins
#2
Greice Krautz-Peterson, Michelle Debatis, Jacqueline M Tremblay, Sergio C Oliveira, Akram A Da'dara, Patrick J Skelly, Charles B Shoemaker
Schistosomiasis is a major disease of the developing world for which no vaccine has been successfully commercialized. While numerous Schistosoma mansoni worm antigens have been identified that elicit antibody responses during natural infections, little is known as to the identities of the schistosome antigens that are most prominently recognized by antibodies generated through natural infection. Non-reducing western blots probed with serum from schistosome-infected mice, rats and humans on total extracts of larval or adult schistosomes revealed that a small number of antigen bands predominate in all cases...
January 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28094052/the-association-of-cancer-risks-with-pentachlorophenol-exposure-focusing-on-community-population-in-the-areas-along-certain-section-of-yangtze-river-in-china
#3
Yanjie Cui, Ling Liang, Qi Zhong, Qian He, Xiaomei Shan, Keyang Chen, Fen Huang
Pentachlorophenol (PCP) was used in large quantities, and mainly for killing the intermediate host snails of schistosome in China, thereby resulting in ubiquitous PCP residue in the environment. However, studies considering the carcinogenicity of PCP for humans mainly focused on occupational workers, and the actual carcinogenicity of PCP for general population is uncertain. To investigate the association between cancer risks and PCP exposure in a community population, an ecological study was conducted in three contaminated areas along the Yangtze River...
January 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28089171/protease-inhibitors-of-parasitic-flukes-emerging-roles-in-parasite-survival-and-immune-defence
#4
REVIEW
Shiwanthi L Ranasinghe, Donald P McManus
Protease inhibitors play crucial roles in parasite development and survival, counteracting the potentially damaging immune responses of their vertebrate hosts. However, limited information is currently available on protease inhibitors from schistosomes and food-borne trematodes. Future characterization of these molecules is important not only to expand knowledge on parasitic fluke biology but also to determine whether they represent novel vaccine and/or drug targets. Moreover, protease inhibitors from flukes may represent lead compounds for the development of a new range of therapeutic agents against inflammatory disorders and cancer...
January 11, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28088239/towards-interruption-of-schistosomiasis-transmission-in-sub-saharan-africa-developing-an-appropriate-environmental-surveillance-framework-to-guide-and-to-support-end-game-interventions
#5
REVIEW
J Russell Stothard, Suzy J Campbell, Mike Y Osei-Atweneboana, Timothy Durant, Michelle C Stanton, Nana-Kwadwo Biritwum, David Rollinson, Dieudonné R Eloundou Ombede, Louis-Albert Tchuem-Tchuenté
Schistosomiasis is a waterborne parasitic disease in sub-Saharan Africa, particularly common in rural populations living in impoverished conditions. With the scale-up of preventive chemotherapy, national campaigns will transition from morbidity- to transmission-focused interventions thus formal investigation of actual or expected declines in environmental transmission is needed as 'end game' scenarios arise. Surprisingly, there are no international or national guidelines to do so in sub-Saharan Africa. Our article therefore provides an introduction to key practicalities and pitfalls in the development of an appropriate environmental surveillance framework...
January 14, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28069074/a-next-generation-microarray-further-reveals-stage-enriched-gene-expression-pattern-in-the-blood-fluke-schistosoma-japonicum
#6
Pengfei Cai, Shuai Liu, Xianyu Piao, Nan Hou, Hong You, Donald P McManus, Qijun Chen
BACKGROUND: Schistosomiasis is caused by infection with blood flukes of the genus Schistosoma, and ranks, in terms of disability-adjusted life years (DALYs), as the third most important neglected tropical disease. Schistosomes have several discrete life stages involving dramatic morphological changes during their development, which require subtle gene expression modulations to complete the complex life-cycle. RESULTS: In the current study, we employed a second generation schistosome DNA chip printed with the most comprehensive probe array for studying the Schistosoma japonicum transcriptome, to explore stage-associated gene expression in different developmental phases of S...
January 10, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28066871/cysteine-protease-inhibitor-of-schistosoma-japonicum-a-parasite-derived-negative-immunoregulatory-factor
#7
Lin Chen, Baohua He, Wei Hou, Li He
Studies have shown that cysteine protease inhibitors from some parasites have immunosuppressive effects on the host. We previously have cloned a novel cysteine protease inhibitor from Schistosoma japonicum and purified its recombinant version (protein named rSj-C). Its possible inhibitory effect on the host immune response has not been described.This study shows that rSj-C inhibits lysosomal cysteine protease of murine dendritic cells (DCs). After DCs were incubated with rSj-C and then with soluble adult worm antigen (AWA) of S...
January 9, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28060841/genomes-of-fasciola-hepatica-from-the-americas-reveal-colonization-with-neorickettsia-endobacteria-related-to-the-agents-of-potomac-horse-and-human-sennetsu-fevers
#8
Samantha N McNulty, Jose F Tort, Gabriel Rinaldi, Kerstin Fischer, Bruce A Rosa, Pablo Smircich, Santiago Fontenla, Young-Jun Choi, Rahul Tyagi, Kymberlie Hallsworth-Pepin, Victoria H Mann, Lakshmi Kammili, Patricia S Latham, Nicolas Dell'Oca, Fernanda Dominguez, Carlos Carmona, Peter U Fischer, Paul J Brindley, Makedonka Mitreva
Food borne trematodes (FBTs) are an assemblage of platyhelminth parasites transmitted through the food chain, four of which are recognized as neglected tropical diseases (NTDs). Fascioliasis stands out among the other NTDs due to its broad and significant impact on both human and animal health, as Fasciola sp., are also considered major pathogens of domestic ruminants. Here we present a reference genome sequence of the common liver fluke, Fasciola hepatica isolated from sheep, complementing previously reported isolate from cattle...
January 6, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28040484/development-of-an-experimental-model-of-schistosomal-myeloradiculopathy
#9
Tiago Pinheiro Vaz de Carvalho, Teresa Cristina Abreu Ferrari, Josimari Melo de Santana, Victor Antônio Santos Viana, José Aislan Correia Santos, Wheverton Correia do Nascimento, Kamilla Mayara Lucas da Cruz, Karina Conceição Gomes Machado de Araújo
Schistosomal myeloradiculopathy (SMR) is a severe form of presentation of schistosomiasis in which Schistosoma spp. affect the spinal cord. The aims of the present study were to develop an animal model of SMR caused by S. mansoni, to characterize both sensory and motor abnormalities in the infected animals, and to investigate the relationship of the sensory, motor and histological findings with the progression of the infection over time. Mechanical sensitivity and behavioral tests were performed followed by euthanasia in male Wistar rats divided into six groups of five animals each, on days 5, 10, 20 and 30 after infection of S...
December 28, 2016: Acta Tropica
https://www.readbyqxmd.com/read/28030359/exploring-possibilities-for-an-alternative-approach-in-experimental-schistosomiasis-mansoni-the-peritoneal-cavity-of-mice
#10
Vitor L T Mati, Rosilene S Bicalho, Alan L Melo
The schistosome oviposition and granuloma constitution in the peritoneal cavity of AKR/J mice were evaluated. Groups of mice intraperitoneally infected with cercariae of Schistosoma mansoni were weekly euthanized during the acute (56 to 84 days post-infection (DPI)) and chronic (147 to 175 DPI) phase of infection. Schistosome developmental stages obtained via peritoneal lavage and perfusion of the portal system were inspected, counted and fixed, and peritoneal granulomata were then processed for histology. The morphological characterization and quantitative analysis of peritoneal schistosome eggs and granulomata were for the first time performed, such as the demonstration of the viability of miracidia obtained there from...
March 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28030347/reduced-14c-methionine-uptake-and-fecundity-in-schistosoma-mansoni-females-treated-with-recombinant-tumor-necrosis-factor-%C3%AE-in-vitro
#11
M A Haseeb, Raag Agrawal, Bernard Fried
Recombinant human TNFα (rhTNFα) has previously been shown to reduce fecundity in Schistosoma mansoni adult females maintained in vitro without males, and adversely affect the uptake of [14C]-tyrosine, an amino acid required for schistosome vitellogenesis. Here we report on the effect of rhTNFα on [14C]-methionine uptake in both separated and paired females, and the effect of three different preparations of rTNFα on schistosome oviposition in vitro. In the absence of rhTNFa, separated females incorporated only 30% of the [14C]-methionine incorporated by paired females in a dose and time-dependent manner, suggesting low metabolic activity of females in the absence of males...
March 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28027317/infection-with-schistosoma-mansoni-has-an-effect-on-quality-of-life-but-not-on-physical-fitness-in-schoolchildren-in-mwanza-region-north-western-tanzania-a-cross-sectional-study
#12
Safari Kinung'hi, Pascal Magnussen, Godfrey Kaatano, Annette Olsen
BACKGROUND: Infection with Schistosoma mansoni negatively impact children's physical health and may influence their general well-being. The aim of this study was to investigate the effect of S. mansoni infections on a panel of morbidity indicators with emphasis on quality of life (PedsQL; measured in four different dimensions) and physical fitness (measured as VO2 max) among 572 schoolchildren aged 7-8 years. METHODOLOGY/PRINCIPAL FINDINGS: Prevalence of S. mansoni infections was 58...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28018158/estrogen-catechols-detection-as-biomarkers-in-schistosomiasis-induced-cancer-and-infertility
#13
M C Botelho, H Alves, J Richter
Urogenital schistosomiasis is a chronic infection caused by the human blood fluke Schistosoma haematobium. Schistosomiasis haematobium is a known risk factor for cancer leading to squamous cell carcinoma of the urinary bladder (SCC). This is a neglected tropical disease endemic in many countries of Africa and the Middle East. Schistosome eggs produce catechol-estrogens. These molecules are metabolized to active quinones that cause alterations in DNA (leading in other contexts to breast or thyroid cancer). Our group have shown that schistosome egg associated catechol estrogens induce tumor-like phenotypes in urothelial cells, originated from parasite estrogen-host cell chromosomal DNA adducts and mutations...
2017: Letters in Drug Design & Discovery
https://www.readbyqxmd.com/read/28017636/identification-and-first-characterization-of-smeps8-a-potential-interaction-partner-of-smtk3-and-ser-transcribed-in-the-gonads-of-schistosoma-mansoni
#14
C Buro, C Burmeister, T Quack, C G Grevelding
In eukaryotes the roles of protein kinases (PKs) regulating important biological processes such as growth and differentiation are well known. Molecular, biochemical, and physiological analyses trying to unravel principles of schistosome development have substantiated the importance for PKs also in this parasite. Amongst others the role of SmTK3 was studied, one of the first cellular PKs characterized from Schistosoma mansoni. Its function was demonstrated in mitogenic and differentiation processes in the gonads...
December 22, 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/28012717/schistosoma-hemozoin-and-its-possible-roles
#15
REVIEW
Shu-Hua Xiao, Jun Sun
More than 95years ago Schistosoma pigment had been deemed as a degradation product of haemoglobin. Until the 1950s, scientists initiated to pay attention to understand the hematophagous habit of schistosomes, and to study the degradation of haemoglobin as well as the formation of hemozoin inside the gut of the worms. For a long time, the formation of hemozoin in both Plasmodium and in Schistosoma was considered to be the major route of heme detoxification, and hemozoin served a role in waste disposal. At the beginning of this century, the chemical structure of Schistosoma pigment was confirmed to be identical to that of malarial pigment (hemozoin) and its synthetic analogue, β-hematin...
December 22, 2016: International Journal for Parasitology
https://www.readbyqxmd.com/read/28012027/having-bird-schistosomes-in-mind-the-first-detection-of-bilharziella-polonica-kowalewski-1895-in-the-bird-neural-system
#16
Hanna Prüter, Jiljí Sitko, Oliver Krone
Nasal bird schistosomes can cause bilharziosis in birds and have the potential to cause swimmer's itch in humans. We determined the prevalence of bird schistosomes in 106 mallards (Anas plathyrhynchos) from 11 water sources in Germany from 2014. Dissections were performed focusing on parasitic infections of the neural system. Infections with Trichobilharzia regenti (Horák et al. 1998) were found in 21% of the birds (n = 22), whereas Bilharziella polonica (Kowalewski 1895) were found between the brain membranes (meninges) and the brain, in the spinal cord or in the intestine of 12% of the mallards (n = 13)...
December 23, 2016: Parasitology Research
https://www.readbyqxmd.com/read/28011341/how-schistosomes-alter-the-human-serum-proteome
#17
Akram A Da'dara, Giles Siddons, Melissa Icaza, Qiang Wang, Patrick J Skelly
Schistosomes are intravascular parasitic worms that cause the debilitating disease schistosomiasis. To better understand how these long-lived parasites may subvert host immune and hemostatic capabilities, we examine here the impact of adult Schistosoma mansoni worms on the human serum proteome. Normal human serum (150μl) was incubated at 37°C for one hour either in the presence or absence of adult worms (∼50 pairs). Thereafter parasites were removed, serum samples were labeled and their proteins resolved for comparative analysis by 2D-Differential in-Gel Electrophoresis (2D-DIGE)...
December 20, 2016: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/27990425/comparative-evaluation-of-anthelmintic-activity-of-edible-and-ornamental-pomegranate-ethanolic-extracts-against-schistosoma-mansoni
#18
Doaa A Yones, Dalia M Badary, Hesham M B Sayed, Soad A H Bayoumi, Azza A Khalifa, Ahmed M El-Moghazy
Due to the development of praziquantel (PZQ) schistosomes resistant strains, the discovery of new antischistosomal agents is of high priority in research. This work reported the in vitro and in vivo effects of the edible and ornamental pomegranate extracts against Schistosoma mansoni. Leaves and stem bark ethanolic extracts of both dried pomegranates were prepared at 100, 300, and 500 μg/mL for in vitro and 600 and 800 mg/kg for in vivo. Adult worms Schistosoma mansoni in RPMI-1640 medium for in vitro and S...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27988094/human-schistosomiasis-in-the-post-mass-drug-administration-era
#19
REVIEW
Francisca Mutapi, Rick Maizels, Alan Fenwick, Mark Woolhouse
Profound changes are occurring in the epidemiology of schistosomiasis, a neglected tropical disease caused by a chronic infection with parasitic helminths of the genus Schistosoma. Schistosomiasis currently affects 240 million people worldwide, mostly in sub-Saharan Africa. The advent and proliferation of mass drug administration (MDA) programmes using the drug praziquantel is resulting in substantial increases in the number of people, mainly children aged 6-14 years, being effectively treated, approaching the point where most people in endemic areas will receive one or more treatments during their lifetimes...
December 14, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27987283/non-necrotizing-colonic-granuloma-induced-by-schistosomiasis
#20
Thein Swe, Aama Baqui, Akari Thein Naing, Tajruba Baqui, Jagannath Sherigar, Mohamed Mansour
Schistosomiasis is an important parasitic disease with various clinical presentations caused by trematode blood flukes. It can present with asymptomatic, chronic colonic ulcerations, strictures, or inflammatory mass causing bowel obstruction. Intestinal polyps are uncommon and induced by antigens released from the schistosome eggs that trigger a cell-mediated inflammatory response with granuloma formation involving T cells, macrophages, and necrosis. This is very relevant while evaluating chronic intermittent gastrointestinal symptoms and eosinophilia in an immigrant patient from endemic areas of schistosomiasis...
2016: Journal of Community Hospital Internal Medicine Perspectives
keyword
keyword
9134
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"