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https://www.readbyqxmd.com/read/28969187/disseminated-burkitt-s-lymphoma-with-a-pancreatic-mass-in-a-hiv-positive-woman-diagnosed-by-axillary-lymph-node-biopsy
#1
Godfrey Mutashambara Rwegerera, Yordanka Pina Rivera, Feng Zhou, Kudra Jumanne Chobanga, Sheikh Omar Sesay
Burkitt's Lymphoma (BL) is a highly aggressive B cell lymphoma of non-Hodgkin's type usually presenting in extranodal sites for endemic and sporadic types of the disease. Like other non-Hodgkin's Lymphomas (NHL), HIV positive associated BL is associated with peripheral lymphadenopathy. We present a case of 22-year-old newly diagnosed HIV positive female patient who presented with generalized peripheral lymphadenopathy and obstructive jaundice. Initial work up was suggestive of acute pancreatitis with further evaluation revealing a pancreatic head mass...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28953614/chronic-hepatitis-e-virus-infection-in-a-cirrhotic-patient-a-case-report
#2
Hugo Barragué, Bertrand Condat, Nicolas Petitdidier, Eric Champagne, Christophe Renou, Jacques Izopet, Florence Abravanel
RATIONALE: Acute hepatitis E virus (HEV) infections are usually self-limiting in immunocompetent patients. HEV persistence has been described only in immunosuppressed patients such as solid-organ transplant recipients, patients with hematological diseases, or patients with human immunodeficiency virus (HIV) infection. PATIENT CONCERNS: A 61-year-old patient was admitted in hospital for jaundice and asthenia. DIAGNOSES: The patient had underlying cirrhosis and developed a chronic HEV infection...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28883243/an-hiv-positive-case-of-obstructive-jaundice-caused-by-immune-reconstitution-inflammatory-syndrome-of-tuberculous-lymphadenitis-successfully-treated-with-corticosteroids
#3
Naoaki Watanabe, Ryota Sato, Hideaki Nagai, Hirotoshi Matsui, Akira Yamane, Masahiro Kawashima, Junko Suzuki, Hiroyuki Tashimo, Nobuharu Ohshima, Kimihiko Masuda, Atsuhisa Tamura, Shinobu Akagawa, Akira Hebisawa, Ken Ohta
A 60-year-old man was admitted to our hospital because of a persistent fever with enlargement of multiple lymph nodes in the mediastinum and around the pancreatic head. He was diagnosed with tuberculosis and human immunodeficiency virus infection. We started antiretroviral therapy three weeks after the initiation of anti-tuberculous therapy. Two weeks later, jaundice appeared with dilatation of the biliary tract due to further enlargement of the lymph nodes, which seemed to be immune reconstitution inflammatory syndrome (IRIS)...
October 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28876584/hydatid-disease-in-south-africa-is-it-a-different-disease-in-patients-with-hiv-co-infection
#4
C Kloppers, K Couzens-Bohlin, M Bernon, S Burmeister, S Beningfield, U Kotze, J Krige, E Jonas
BACKGROUND: Echinococcus granulosus remains a clinical problem in rural sheep-farming communities, with HIV co-infection often seen in patients from endemic regions. METHOD: Data from a prospective database was used to identify patients with and without HIV co-infection that underwent surgery for hepatic hydatid disease between 2012 and 2017. Clinical presentation, preoperative intervention, surgical treatment, postoperative mortality and morbidity are reported according to the Accordion severity score...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28642818/nivolumab-as-salvage-treatment-in-a-patient-with-hiv-related-relapsed-refractory-hodgkin-lymphoma-and-liver-failure-with-encephalopathy
#5
Jose D Sandoval-Sus, Francis Mogollon-Duffo, Ankita Patel, Nathan Visweshwar, Damian A Laber, Richard Kim, Michael V Jagal
BACKGROUND: We report the first case to our knowledge of a patient with relapsed/refractory classical hodgkin lymphoma and liver failure with encephalopathy along with human immunodeficiency virus/acquired immunodeficiency syndrome infection, successfully treated with nivolumab without major side effects and encouraging prolonged disease control. CASE PRESENTATION: In December 2015, at the time of the patient's progression from his Hodgkin lymphoma after fourth line treatment, he developed persistent fevers, abdominal distension, jaundice and worsening of his liver function tests...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28582440/development-and-external-validation-of-a-clinical-prognostic-score-for-death-in-visceral-leishmaniasis-patients-in-a-high-hiv-co-infection-burden-area-in-ethiopia
#6
Charles Abongomera, Koert Ritmeijer, Florian Vogt, Jozefien Buyze, Zelalem Mekonnen, Henok Admassu, Robert Colebunders, Rezika Mohammed, Lutgarde Lynen, Ermias Diro, Johan van Griensven
BACKGROUND: In Ethiopia, case fatality rates among subgroups of visceral leishmaniasis (VL) patients are high. A clinical prognostic score for death in VL patients could contribute to optimal management and reduction of these case fatality rates. We aimed to identify predictors of death from VL, and to develop and externally validate a clinical prognostic score for death in VL patients, in a high HIV co-infection burden area in Ethiopia. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a retrospective cohort study in north west Ethiopia...
2017: PloS One
https://www.readbyqxmd.com/read/28464883/late-presentation-of-chronic-viral-hepatitis-for-medical-care-a-consensus-definition
#7
Stefan Mauss, Stanislas Pol, Maria Buti, Erika Duffell, Charles Gore, Jeffrey V Lazarus, Hilje Logtenberg-van der Grient, Jens Lundgren, Antons Mozalevskis, Dorthe Raben, Eberhard Schatz, Stefan Wiktor, Jürgen K Rockstroh
INTRODUCTION: We present two consensus definitions of advanced and late stage liver disease being used as epidemiological tools. These definitions can be applied to assess the morbidity caused by liver diseases in different health care systems. We focus is on hepatitis B and C virus infections, because effective and well tolerated treatments for both of these infections have greatly improved our ability to successfully treat and prevent advanced and late stage disease, especially if diagnosed early...
May 3, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28435232/self-reported-adherence-and-associated-factors-to-isoniazid-preventive-therapy-for-latent-tuberculosis-among-people-living-with-hiv-aids-at-health-centers-in-gondar-town-north-west-ethiopia
#8
Asnakew Achaw Ayele, Seyfe Asrade Atnafie, Demis Driba Balcha, Asegedech Tsegaw Weredekal, Birhanu Alemayehu Woldegiorgis, Mulgeta Melaku Wotte, Begashaw Melaku Gebresillasie
PURPOSE: This study aimed to assess self-reported adherence and associated factors to isoniazid preventive therapy (IPT) for latent tuberculosis among people living with HIV/AIDS (PLWHA) at health centers in Gondar town, North West Ethiopia. PATIENTS AND METHODS: An institution-based prospective cross-sectional study was conducted from March 10 to June 11, 2016. A total of 154 eligible participants were included in the study, using the simple random sampling method, from the available four health centers and one teaching referral hospital that provided antiretroviral therapy (ART) for HIV/AIDS patients...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28380279/causes-and-consequences-of-higher-leishmania-infantum-burden-in-patients-with-kala-azar-a-study-of-625-patients
#9
Danielle A Zacarias, Nuno Rolão, Flaviane A de Pinho, Ingridi Sene, Jailthon C Silva, Teresinha C Pereira, Dorcas L Costa, Carlos H N Costa
BACKGROUND: An infected host's Leishmania infantum load in blood is considered to be an estimate of his or her total parasite burden. Therefore, the measurement of blood parasite burden is important in the identification of factors involved in parasite control. METHODS: Quantitative polymerase chain reaction was performed on blood samples from 625 patients with kala-azar consecutively admitted to a reference hospital in Teresina, Brazil. Primers were used to amplify a segment of kDNA using the TaqMan system...
June 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28357124/antibiotic-associated-suspected-adverse-drug-reactions-among-hospitalized-patients-in-uganda-a-prospective-cohort-study
#10
Ronald Kiguba, Charles Karamagi, Sheila M Bird
We sought to determine the prevalence at admission and incidence during hospitalization of antibiotic-associated suspected adverse drug reactions (aa-ADRs) among Ugandan inpatients; and to characterize these aa-ADRs. We conducted a prospective cohort study of 762 consented adults admitted on medical and gynecological wards of the 1790-bed Mulago National Referral Hospital. Thirty percent were known HIV-seropositive (232/762). Nineteen percent (148/762; 95% CI: 17-22%) of inpatients experienced at least one aa-ADR...
April 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28287204/-biliary-and-kidney-lithiasis-during-treatment-with-daclatasvir-sofosbuvir-ribavirin-and-atazanavir-ritonavir-abacavir-lamivudine-in-an-hiv-hcv-genotype-4-infected-patient-a-case-report
#11
Andrea Vavassori, Paola Lanza, Ilaria Izzo, Salvatore Casari, Silvia Odolini, Serena Zaltron, Elena Festa, Francesco Castelli
New Direct-acting Antiviral Agents (DAA)-based anti-HCV therapies currently provide extraordinary opportunities to cure patients. Drug-drug interactions are however a real challenge during treatment. In particular, in HIV-infected patients in cART, DAA choice is limited by such interactions, which can result both in reduced efficacy and toxicity. We report the case of a HIV-infected patient on cART with atazanavir/ritonavir/abacavir/lamivudine, who presented kidney and biliary lithiasis, the latter treated with endoscopic retrograde cholangiopancreatography and endoscopic biliary sphincterotomy, after beginning anti-HCV treatment with daclatasvir/sofosbuvir/ribavirin...
February 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28202897/dual-infection-with-hepatitis-b-and-epstein-barr-virus-presenting-with-severe-jaundice-coagulopathy-and-hepatitis-b-virus-chronicity-outcome
#12
Sirish C Rao, Imran Ashraf, Fazia Mir, Sami Samiullah, Jamal A Ibdah, Veysel Tahan
BACKGROUND Hepatitis B virus (HBV) has been reported as a coinfection with hepatitis C virus (HCV), hepatitis D virus (HDV), cytomegalovirus (CMV), and human immunodeficiency virus (HIV). CASE REPORT A 34-year-old female presented to our clinic with epigastric pain and severe acute hepatitis manifested as jaundice associated with hyperbilirubinemia, elevated transaminases, and coagulopathy. The patient was diagnosed with acute HBV with Epstein-Barr virus (EBV) coinfection leading to subsequent chronic hepatitis B...
February 16, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/27827877/acute-hepatitis-e-two-sides-of-the-same-coin
#13
REVIEW
Johannes Hartl, Malte H Wehmeyer, Sven Pischke
The relevance of acute hepatitis E virus (HEV) infections has been underestimated for a long time. In the past, HEV infection had been interpreted falsely as a disease limited to the tropics until the relevance of autochthonous HEV infections in the Western world became overt. Due to increased awareness, the incidence of diagnosed autochthonous HEV infections (predominantly genotype 3) in industrialized countries has risen within the last decade. The main source of infections in industrialized countries seems to be infected swine meat, while infections with the tropical HEV genotypes 1 and 2 usually are mainly transmitted fecal-orally by contaminated drinking water...
November 3, 2016: Viruses
https://www.readbyqxmd.com/read/27639183/sofosbuvir-and-ribavirin-for-6-weeks-is-not-effective-among-people-with-recent-hepatitis-c-virus-infection-the-dare-c-ii-study
#14
MULTICENTER STUDY
Marianne Martinello, Edward Gane, Margaret Hellard, Joe Sasadeusz, David Shaw, Kathy Petoumenos, Tanya Applegate, Jason Grebely, Laurence Maire, Philippa Marks, Gregory J Dore, Gail V Matthews
While interferon-based therapy has excellent efficacy in acute and recent hepatitis C virus (HCV) infection, the side effect profile limits implementation. Sofosbuvir and ribavirin for 12-24 weeks is safe and well tolerated in chronic HCV, with efficacy dependent on genotype and disease stage. The aim of this study was to assess the efficacy of sofosbuvir and ribavirin for 6 weeks in individuals with recent HCV infection. In this open-label study conducted in Australia and New Zealand, adults with recent HCV (duration of infection <12 months) received sofosbuvir 400 mg daily and weight-based ribavirin (<75 kg, 1,000 mg/day; ≥75 kg, 1,200 mg/day) for 6 weeks...
December 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27365926/disseminated-histoplasmosis-a-fatal-opportunistic-infection-in-disguise
#15
Ruchita Tyagi, Arshdeep Kaur, Pavneet Kaur Selhi, Harpreet Kaur Puri, Neena Sood
Histoplasma capsulatum is no longer confined to certain geographic areas and should always be considered in the differential diagnosis of lymphadenopathy and organomegaly in HIV-positive patients. We present an unusual case of a 20-year-old immunocompromised male of African origin presenting with fever, jaundice, hepatosplenomegaly, and retroperitoneal and cervical lymphadenopathy. Fine needle aspiration (FNA) smears from the cervical lymph node revealed numerous yeast forms of histoplasma in macrophages. The patient succumbed to the fulminant infection...
July 2016: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/27276735/clinical-characteristics-of-histoplasmosis-in-siriraj-hospital
#16
Panibud Wongprommek, Methee Chayakulkeeree
BACKGROUND: Histoplasmosis is a rare infectious disease caused by Histoplasmosis capsulatum (H. capsulatum), a dimorphic fungus. Histoplasmosis is not endemic to Thailand. Cases of histoplasmosis are sporadic and mostly associated with HIV disease. Clinical characteristics and treatment outcomes of histoplasmosis in Thai patients have not been well described. OBJECTIVE: To investigate the clinical characteristics and outcomes of patients with histoplasmosis at Siriraj Hospital in Bangkok, Thailand MATERIAL AND METHOD: This retrospective investigation studied adult patients with histoplasmosis who attended Siriraj Hospital for treatment between 2002 and 2012 (11 years)...
March 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/27194892/hepatitis-c-virus-infection-in-patients-with-end-stage-renal-disease-a-study-from-a-tertiary-care-centre-in-india
#17
Anil Arora, Naresh Bansal, Praveen Sharma, Vikas Singla, Varun Gupta, Pankaj Tyagi, Manish Malik, Ashish Kumar
BACKGROUND: Hepatitis C Virus (HCV) infection is common in patients with end stage renal disease (ESRD) and is an important cause of liver disease. We describe the demographic, clinical and biochemical profile of these patients from a tertiary care center of north India. METHODS: Records of consecutive patients of HCV infection with ESRD on maintenance hemodialysis or with renal transplantation who presented to our unit from January 2009 to June 2013 were analyzed...
March 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/26715956/supra-treatment-threshold-neonatal-jaundice-incidence-in-hiv-exposed-compared-to-non-exposed-neonates-at-queen-elizabeth-central-hospital-in-blantyre-malawi
#18
COMPARATIVE STUDY
W Nakanga, P Patel, S Panjwani, N Kennedy, K Kawaza
INTRODUCTION: Jaundice is the yellowish pigmentation of the skin, sclera, and mucous membranes resulting from bilirubin deposition. Children born to mothers with HIV are more likely to be born premature, with low birth weight, and to become septic-all risk factors for neonatal jaundice. Further, there has been a change in the prevention of mother-to-child transmission (PMTCT) of HIV guidelines from single-dose nevirapine to a six-week course, all of which theoretically put HIV-exposed newborns at greater risk of developing neonatal jaundice...
September 2015: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/26591696/predictors-of-outcome-among-patients-with-obstructive-jaundice-at-bugando-medical-centre-in-north-western-tanzania
#19
Joseph B Mabula, Japhet M Gilyoma, Mabula D Mchembe, Hyasinta Jaka, Erasmus Kamugisha, Benson Kidenya, Peter F Rambau, Phillipo L Chalya
Despite recent advances both in preoperative diagnosis and postoperative care, obstructive jaundice still contributes significantly to high morbidity and mortality. A prospective study was undertaken to identify predictors of outcome among patients with obstructive jaundice at Bugando Medical Centre in north-western Tanzania. A total of 138 patients were studied. The male to female ratio was 1:1.6. The median age of patients was 58 years. Patients with malignant obstructive jaundice were older than those of benign type (P < 0...
October 2013: Tanzania Journal of Health Research
https://www.readbyqxmd.com/read/26577440/primary-gastric-tuberculosis-presenting-as-gastric-outlet-obstruction-a-case-report-and-review-of-the-literature
#20
REVIEW
Nassir Alhaboob Arabi, Abdulmagid M Musaad, Elsaggad Eltayeb Ahmed, Mohammed M A M Ibnouf, Muataz Salah Eldin Abdelaziz
INTRODUCTION: Tuberculosis is a major health problem worldwide. Sudan has high burden of tuberculosis (TB) with a prevalence of 209 cases per 100,000 of the population and it is commonly presented with pulmonary disease but involvement of the gastrointestinal tract is not uncommon. Abdominal tuberculosis comprises about 1-3 % of all cases of tuberculosis and about 12% of extrapulmonary tuberculosis. It involves the ileocecal region, but involvement of stomach and duodenum are rare sites...
November 18, 2015: Journal of Medical Case Reports
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