keyword
https://read.qxmd.com/read/38537007/independent-predictors-for-non-alcoholic-fatty-liver-disease-in-patients-with-treatment-na%C3%A3-ve-chronic-hepatitis-b
#1
JOURNAL ARTICLE
Gulsah Tuncer, Ceyda Geyiktepe-Guclu, Osman Faruk Bayramlar, Burcu Atasoy Bozan, Cigdem Yucel, Betul Copur, Kadir Gorkem Guclu, Mustafa Yıldırım, Gonul Sengöz, Filiz Pehlivanoglu
OBJECTIVE: There are limited data on non-alcoholic fatty liver disease in chronic hepatitis B virus infection. We aimed to determine the predictors for non-alcoholic fatty liver disease in patients with treatment-naïve chronic hepatitis B virus infection. METHODS: All consecutive treatment-naïve patients with chronic hepatitis B virus infection at the Haseki Training and Research Hospital between October 1, 2021, and September 31, 2022, were retrospectively enrolled...
2024: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/38530710/hiv-hbv-coinfection-understanding-the-complex-interactions-and-their-impact-on-spontaneous-hbv-clearance-chronic-liver-damage-cirrhosis-and-hepatocellular-carcinoma
#2
JOURNAL ARTICLE
Jingwen Xiao, Yongzheng Zhang, Jia Wu, Xinping -Chen, Wei Zou
Compared to either HIV or hepatitis B virus (HBV) monoinfected individuals, HIV/HBV-coinfected individuals have a decreased probability of spontaneous HBV clearance and a greater risk of developing chronic liver damage and a faster progression to cirrhosis and hepatocellular carcinoma. This manuscript attempts to provide a comprehensive review of the landscape of current HIV/HBV coinfection research with a focus on the intricate interactions between these two viruses. Our review will help understand the disease dynamics of HIV/HBV coinfection and has important implications for designing public health strategies...
2024: AIDS Reviews
https://read.qxmd.com/read/38523735/risk-factors-for-development-of-cirrhosis-in-chronic-viral-hepatitis-b-patients-who-had-persistent-viral-suppression-with-antiviral-therapy
#3
JOURNAL ARTICLE
Soe T Maung, Pakanat Decharatanachart, Sombat Treeprasertsuk, Roongruedee Chaiteerakij
BACKGROUND AND AIMS: Chronic viral hepatitis B (CHB)-infected patients occasionally develop cirrhosis despite having persistent viral suppression with antiviral therapy. We aimed to identify risk factors for developing cirrhosis in hepatitis B virus (HBV)-suppressed patients. METHODS: We conducted a case-control study involving 120 noncirrhotic CHB-infected patients achieving viral suppression with antiviral treatment, with 40 cases developing cirrhosis and 80 age-, sex-, and Fibrosis-4 (FIB-4)-matched controls...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38518655/predictors-of-liver-disease-progression-in-people-living-with-hiv-hbv-co-infection-on-antiretroviral-therapy
#4
JOURNAL ARTICLE
Kasha P Singh, Anchalee Avihingsanon, Jennifer M Zerbato, Wei Zhao, Sabine Braat, Surekha Tennakoon, Ajantha Rhodes, Gail V Matthews, Christopher K Fairley, Joe Sasadeusz, Megan Crane, Jennifer Audsley, Sharon R Lewin
BACKGROUND: In people living with HIV-HBV, liver fibrosis progression can occur even with suppressive antiretroviral therapy (ART). We investigated the relationship between liver fibrosis and biomarkers of inflammation, apoptosis, and microbial translocation. METHODS: In this observational cohort study adults living with HIV-HBV already on effective ART were recruited in Australia and Thailand and followed for 3 years including 6 monthly clinical review and blood tests and annual transient elastography...
March 21, 2024: EBioMedicine
https://read.qxmd.com/read/38510585/detection-of-enteropathogens-in-human-immunodeficiency-virus-and-non-human-immunodeficiency-virus-infected-children-with-acute-diarrhea-in-an-indonesian-tertiary-hospital-using-multiplex-real-time-polymerase-chain-reaction
#5
JOURNAL ARTICLE
Dewi Wulandari, Rivaldi Febrian, Pramita Gayatri Dwipoerwantoro, Nia Kurniati
PURPOSE: Diarrhea is one of the leading causes of mortality in children living in developing countries. The etiology of acute diarrhea in each healthcare center varies depending on place, time, and population. This study aimed to identify pathogen patterns in human immunodeficiency virus (HIV)-infected and non-HIV children suffering from acute diarrhea, using multiplex real time reverse transcriptase polymerase chain reaction (RT-PCR), in an Indonesian tertiary hospital. METHODS: This cross-sectional study was conducted at Dr...
March 2024: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/38505248/hepatitis-e-virus-hev-infection-among-immunocompromised-individuals-a-brief-narrative-review
#6
REVIEW
Radostina Alexandrova, Ilia Tsachev, Plamen Kirov, Abedulkadir Abudalleh, Hristo Hristov, Tanya Zhivkova, Lora Dyakova, Magdalena Baymakova
Hepatitis E virus (HEV) is a single-stranded positive-sense RNA virus that belongs to Hepeviridae family. HEV is the most common cause of acute viral hepatitis worldwide. According to the World Health Organization (WHO), there are estimated 20 million HEV infections worldwide every year, leading to estimated 3.3 million symptomatic cases of HEV infection. The WHO estimates that HEV infection caused approximately 44,000 deaths in 2015, which represents 3.3% of mortality rates due to viral hepatitis. In low-income (LI) countries and lower-middle-income (LMI) countries, HEV is a waterborne infection induced by HEV genotype (gt) 1 and HEV gt 2 that cause large outbreaks and affect young individuals with a high mortality rate in pregnant women from South Asian countries and patients with liver diseases...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38489521/imaging-based-non-invasive-liver-disease-assessment-for-staging-liver-fibrosis-in-chronic-liver-disease-a-systematic-review-supporting-the-aasld-practice-guideline
#7
JOURNAL ARTICLE
Andres Duarte-Rojo, Bachir Taouli, Daniel H Leung, Deborah Levine, Tarek Nayfeh, Bashar Hasan, Yahya Alsawaf, Samer Saadi, Abdul Mounaem Majzoub, Apostolos Manolopoulos, Samir Hafar, Ayca Dundar, M Hassan Murad, Don C Rockey, Mouaz Alsawas, Richard K Sterling
BACKGROUND AND AIMS: Transient elastography (TE), shear-wave elastography (SWE), and/or magnetic resonance elastography (MRE), each providing liver stiffness measurement (LSM), are the most studied imaging-based noninvasive liver disease assessment (NILDA) techniques. To support the American Association for the Study of Liver Diseases guidelines on NILDA, we summarized the evidence on the accuracy of these LSM methods to stage liver fibrosis (F). APPROACH AND RESULTS: A comprehensive search for studies assessing LSM by TE, SWE, or MRE for the identification of significant fibrosis (F2-4), advanced fibrosis (F3-4), or cirrhosis (F4), utilizing histopathology as standard of reference by liver disease etiology in adults or children from inception to April 2022 was performed...
March 15, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38489517/accuracy-of-blood-based-biomarkers-for-staging-liver-fibrosis-in-chronic-liver-disease-a-systematic-review-supporting-the-aasld-practice-guideline
#8
JOURNAL ARTICLE
Keyur Patel, Sumeet K Asrani, Maria Isabel Fiel, Deborah Levine, Daniel H Leung, Andres Duarte-Rojo, Jonathan A Dranoff, Tarek Nayfeh, Bashar Hasan, Tamar H Taddei, Yahya Alsawaf, Samer Saadi, Abdul Mounaem Majzoub, Apostolos Manolopoulos, Muayad Alzuabi, Jingyi Ding, Nigar Sofiyeva, M Hassan Murad, Mouaz Alsawas, Don C Rockey, Richard K Sterling
BACKGROUND AND AIMS: Blood-based biomarkers have been proposed as an alternative to liver biopsy for non-invasive liver disease assessment (NILDA) in chronic liver disease (CLD). Our aims for this systematic review were to evaluate the diagnostic utility of selected blood-based tests either alone, or in combination, for identifying significant fibrosis (F2-4), advanced fibrosis (F3-4) and cirrhosis (F4), as compared to biopsy in CLD. APPROACH AND RESULTS: We included a comprehensive search of databases including Ovid MEDLINE(R), EMBASE, Cochrane Database, and Scopus through to April 2022...
March 15, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38483035/direct-acting-antivirals-in-women-of-reproductive-age-infected-with-hepatitis-c-virus
#9
JOURNAL ARTICLE
Krystyna Dobrowolska, Małgorzata Pawłowska, Dorota Zarębska-Michaluk, Piotr Rzymski, Ewa Janczewska, Magdalena Tudrujek-Zdunek, Hanna Berak, Włodzimierz Mazur, Jakub Klapaczyński, Beata Lorenc, Justyna Janocha-Litwin, Anna Parfieniuk-Kowerda, Dorota Dybowska, Anna Piekarska, Rafał Krygier, Beata Dobracka, Jerzy Jaroszewicz, Robert Flisiak
Eliminating hepatitis C virus (HCV) infection in the population of women of reproductive age is important not only for the health of women themselves but also for the health of newborns. This study aimed to evaluate the implementation of this goal by analysing the effectiveness of contemporary therapy in a large cohort from everyday clinical practice along with identifying factors reducing therapeutic success. The analysed population consisted of 7861 patients, including 3388 women aged 15-49, treated in 2015-2022 in 26 hepatology centres...
March 14, 2024: Journal of Viral Hepatitis
https://read.qxmd.com/read/38477465/impact-of-human-immunodeficiency-virus-infection-on-liver-and-cardiovascular-outcomes-in-veterans-with-metabolic-dysfunction-associated-steatotic-liver-disease
#10
JOURNAL ARTICLE
Robert J Wong, Zeyuan Yang, Aaron Yeoh, Albert Do, Aijaz Ahmed, Ramsey Cheung
OBJECTIVE: Hepatic steatosis in highly prevalent in people living with human immunodeficiency virus (HIV). It remains unclear whether HIV in patients with metabolic dysfunction associated steatotic liver disease (MASLD) is associated with greater risks of liver disease progression and cardiovascular disease (CVD). We aim to evaluate the impact of HIV infection on risks of liver and CVD outcomes among U.S. Veterans with MASLD. METHODS: Using national Veterans Administration data from 2010-2022, we created a propensity score matched cohort of MASLD patients with vs...
March 13, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38459735/personalized-care-approaches-to-hepatitis-c-therapy-recent-advances-and-future-directions
#11
REVIEW
Nicola Schiano Moriello, Biagio Pinchera, Ivan Gentile
INTRODUCTION: The introduction of direct-acting antivirals (DAAs) has significantly transformed the therapeutic landscape for chronic C hepatitis virus (HCV) infection. However, there is still room for further improvement in optimizing therapy efficacy and minimizing adverse effects. AREAS COVERED: This review is devoted to the rationale for adopting a personalized approach to HCV therapy. Specifically, we explore the role of host-related factors, such as sex or the presence of comorbidities...
March 8, 2024: Expert Review of Anti-infective Therapy
https://read.qxmd.com/read/38459720/prevalence-and-risk-factors-of-metabolic-dysfunction-associated-steatotic-liver-disease-in-south-central-uganda-a-cross-sectional-survey
#12
JOURNAL ARTICLE
Rocio Enriquez, Mahmoud Homsi, Robert Ssekubugu, Dorean Nabukalu, Zangin Zeebari, Gaetano Marrone, Bruna Gigante, Larry W Chang, Steven J Reynolds, Fred Nalugoda, Anna Mia Ekström, Hannes Hagström, Helena Nordenstedt
BACKGROUND: Despite numerous risk factors and serious consequences, little is known about metabolic dysfunction-associated steatotic liver disease (MASLD) at population level in Africa. AIM: The aim of the study was to estimate the prevalence and risk factors of MASLD in people living with and without HIV in Uganda. METHODS: We collected data from 37 communities in South Central Uganda between May 2016 and May 2018. We estimated MASLD prevalence using the fatty liver index and advanced liver fibrosis using the dynamic aspartate-to-alanine aminotransferase ratio...
March 8, 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38452004/clinical-outcomes-and-prognostic-factors-after-hcv-clearance-with-daa-in-hiv-hcv-coinfected-patients-with-advanced-fibrosis-cirrhosis
#13
JOURNAL ARTICLE
Juan Berenguer, Teresa Aldámiz-Echevarría, Víctor Hontañón, Chiara Fanciulli, Carmen Quereda, Carmen Busca, Lourdes Domínguez, Cristina Hernández, Jorge Vergas, Gabriel Gaspar, Lucio J García-Fraile, Cristina Díez, Marta De Miguel, José M Bellón, Rafael Bañares, Juan González-García
AIMS AND BACKGROUND: We assessed long-term clinical outcomes and prognostic factors for liver disease progression after sustained viral response (SVR) with direct-acting antivirals (DAAs) in HIV/HCV coinfected patients with advanced fibrosis (AdF) or cirrhosis. APPROACH AND RESULTS: A total of 1,300 patients who achieved SVR with DAAs from 2014 to 2017 in Spain were included: 1145 with chronically advanced liver disease (cACLD) (384 AdF and 761 compensated cirrhosis [CoC]) and 155 with decompensated cirrhosis (DeC)...
March 7, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38411618/the-relationship-of-age-and-comorbid-conditions-to-hospital-and-nursing-home-days-in-medicaid-recipients-with-hiv
#14
JOURNAL ARTICLE
Ira B Wilson, Megan B Cole, Yoojin Lee, Theresa I Shireman, Amy C Justice, Momotazur Rahman
OBJECTIVE: To determine how aging impacts health care utilization in persons with HIV (PWH) compared to persons without HIV (PWoH). DESIGN: Matched case-control study. METHODS: We studied Medicaid recipients in the United States, aged 18-64 years, from 2001 to 2012. We matched each of 270,074 PWH to three PWoH by baseline year, age, gender, and zip code. Outcomes were hospital and nursing home days per month (DPM). Comorbid condition groups were cardiovascular disease, diabetes, liver disease, mental health conditions, pulmonary disease, and renal disease...
February 22, 2024: AIDS
https://read.qxmd.com/read/38408219/relationship-between-vitamin-d-deficiency-and-nonalcoholic-fatty-liver-disease-in-patients-with-hiv-1-infection
#15
JOURNAL ARTICLE
Leonardo Calza, Maddalena Giglia, Pierluigi Viale
No abstract text is available yet for this article.
March 1, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://read.qxmd.com/read/38407882/renal-dysfunction-during-treatment-of-chronic-hepatitis-b-with-tenofovir-disoproxyl-fumarate-and-associated-risk-factors
#16
JOURNAL ARTICLE
Alessandra M de A Maciel, Maria Lucia C G Ferraz, Renata de M Perez, Carlos Eduardo Brandão-Mello
OBJECTIVES: To analyze the evolution of glomerular filtration rate (GFR) and the presence of renal tubular dysfunction during the treatment of chronic hepatitis B virus (HBV) infection with tenofovir disoproxil fumarate (TDF) and to determine the risk factors involved. METHODS: Retrospective cohort observational study of adults with chronic hepatitis B. Exclusion: hepatitis C virus-HBV coinfection, diabetes, baseline GFR less than 60 ml/min. Measurements of serum and urinary creatinine and phosphate; urinary albumin, retinol-binding protein (RBP) and neutrophil gelatinase-associated lipocalin (NGAL) were performed...
February 16, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38401140/editorial-updated-epidemiology-of-steatotic-liver-disease-in-people-with-hiv-in-the-united-states-authors-reply
#17
EDITORIAL
Samer Gawrieh, Mark Sulkowski, Naga Chalasani, Rohit Loomba
No abstract text is available yet for this article.
March 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38401138/editorial-updated-epidemiology-of-steatotic-liver-disease-in-people-with-hiv-in-the-united-states
#18
EDITORIAL
Richie Manikat, Seung Up Kim, Aijaz Ahmed, Donghee Kim
No abstract text is available yet for this article.
March 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38400071/siv-infection-is-associated-with-transient-acute-phase-steatosis-in-hepatocytes-in-vivo
#19
JOURNAL ARTICLE
Nina Derby, Sreya Biswas, Sofiya Yusova, Cristina Luevano-Santos, Maria Cristina Pacheco, Kimberly A Meyer, Brooke I Johnson, Miranda Fischer, Katherine A Fancher, Cole Fisher, Yohannes M Abraham, Conor J McMahon, Savannah S Lutz, Jeremy V Smedley, Benjamin J Burwitz, Donald L Sodora
Metabolic-dysfunction-associated fatty liver disease (MAFLD) is a major cause of morbidity and mortality in HIV-infected individuals, even those receiving optimal antiretroviral therapy. Here, we utilized the SIV rhesus macaque model and advanced laparoscopic techniques for longitudinal collection of liver tissue to elucidate the timing of pathologic changes. The livers of both SIV-infected (N = 9) and SIV-naïve uninfected (N = 8) macaques were biopsied and evaluated at four time points (weeks -4, 2, 6, and 16-20 post-infection) and at necropsy (week 32)...
February 15, 2024: Viruses
https://read.qxmd.com/read/38394618/non-invasive-liver-fibrosis-markers-in-the-evaluation-of-fibrosis-regression-after-direct-acting-antiviral-daa-therapy
#20
JOURNAL ARTICLE
Julio Collazos, Víctor Asensi
No abstract text is available yet for this article.
February 23, 2024: Journal of Infectious Diseases
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