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https://www.readbyqxmd.com/read/28074326/minimally-invasive-staging-surgery-in-women-with-early-stage-endometrial-cancer-analysis-of-the-national-cancer-data-base
#1
Amy J Bregar, Alexander Melamed, Elisabeth Diver, Joel T Clemmer, Shitanshu Uppal, John O Schorge, Laurel W Rice, Marcela G Del Carmen, J Alejandro Rauh-Hain
PURPOSE: The aim of this study was to determine factors associated with the adoption of minimally invasive surgery (MIS) compared with laparotomy in the treatment of endometrial cancer and to compare surgical outcomes and survival between these two surgical modalities. METHODS: We utilized the National Cancer Data Base (NCDB) to identify women diagnosed with presumed early-stage endometrial cancer between 2010 and 2012. We also identified factors associated with the performance of MIS and utilized propensity score matching to create a matched cohort of women who underwent minimally invasive staging surgery or laparotomy for surgical staging...
January 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28059913/liposomal-bupivacaine-use-in-transversus-abdominis-plane-blocks-reduces-pain-and-postoperative-intravenous-opioid-requirement-after-colorectal-surgery
#2
Audrey L Stokes, Sanjib D Adhikary, Ashley Quintili, Frances J Puleo, Christine S Choi, Christopher S Hollenbeak, Evangelos Messaris
BACKGROUND: Enhanced recovery protocols frequently use multimodal postoperative analgesia to improve postoperative outcomes in patients undergoing colorectal surgery. OBJECTIVE: The purpose of this study was to evaluate liposomal bupivacaine use in transversus abdominis plane blocks on postoperative pain scores and opioid use after colorectal surgery. DESIGN: This was a retrospective cohort study comparing outcomes between patients receiving nonliposomal anesthetic (n = 104) and liposomal bupivacaine (n = 303) blocks...
February 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28058143/evaluation-of-the-analgesic-efficacy-of-dexketoprofen-added-to-paracetamol
#3
Dilek Ceyhan, Ayten Bilir, Mehmet Sacit Güleç
OBJECTIVE: Multimodal analgesic methods are preferred for the treatment of postoperative pain; as a result, the additive effects of analgesics are provided while probable side effects are avoided. The current study aimed to compare the effects of the combination of dexketoprofen and paracetamol with regard to postoperative pain therapy. METHODS: Ninety-six patients who underwent non-malignant gynaecological laparotomy operations were included in this study. Patients were randomized into 3 groups...
December 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/28052686/henoch-sch%C3%A3-nlein-purpura-as-a-rare-cause-of-an-acute-abdomen
#4
M Davies, M Nanda Kumar, V Shetty, P Mitchell
A 52-year-old man presented with a purpuric rash affecting his legs and hypertension. He was diagnosed with Henoch-Schönlein purpura and discharged with non-steroidal anti-inflammatory drugs. Three weeks later, he presented again with loss of appetite and vomiting before developing abdominal pain with pyrexia of 38.5°C and rigors. On examination, he was hypotensive with a distended abdomen and a national early warning score of 6. Computed tomography revealed enteropathy of Henoch-Schönlein purpura. The patient deteriorated and went for an emergency laparotomy, where 30cm of ischaemic small bowel was resected...
January 4, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28049498/should-we-perform-a-fast-exam-in-haemodynamically-stable-patients-presenting-after-blunt-abdominal-injury-a-retrospective-cohort-study
#5
D Dammers, M El Moumni, I I Hoogland, N Veeger, E Ter Avest
BACKGROUND: Focussed Assessment with Sonography for Trauma (FAST) is a bedside ultrasonography technique used to detect free intraperitoneal fluid in patients presenting with blunt abdominal trauma (BAT) in the emergency department. METHODS: In this retrospective cohort study we investigated the potential of FAST as a risk stratification instrument in haemodynamically (HD) stable patients presenting after BAT by establishing the association between the FAST exam result and final outcome...
January 3, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28046187/development-of-a-gestational-age-specific-case-definition-for-neonatal-necrotizing-enterocolitis
#6
Cheryl Battersby, Nick Longford, Kate Costeloe, Neena Modi
Importance: Necrotizing enterocolitis (NEC) is a major cause of neonatal morbidity and mortality. Preventive and therapeutic research, surveillance, and quality improvement initiatives are hindered by variations in case definitions. Objective: To develop a gestational age (GA)-specific case definition for NEC. Design, Setting, and Participants: We conducted a prospective 34-month population study using clinician-recorded findings from the UK National Neonatal Research Database between December 2011 and September 2014 across all 163 neonatal units in England...
January 3, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28043841/non-opioid-pain-management-in-benign-minimally-invasive-hysterectomy-a-systematic-review
#7
REVIEW
Emily Blanton, Georgine Lamvu, Insiyyah Patanwala, Kenneth I Barron, Kathryn Witzeman, Frank F Tu, Sawsan As-Sanie
BACKGROUND: Less postoperative pain is typically associated with a minimally invasive hysterectomy compared to a laparotomy approach but poor pain control can still be an issues. Multiple guidelines exist for managing postoperative pain yet most are not specialty-specific and are based on procedures bearing little relevance to a minimally invasive hysterectomy. OBJECTIVE: To determine if there is enough quality evidence within the benign gynecology literature to make non-opioid pain control recommendations for women undergoing a benign minimally invasive hysterectomy...
December 30, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28042709/health-related-quality-of-life-and-anxiety-and-depression-in-patients-diagnosed-with-cholangiocarcinoma-a-prospective-cohort-study
#8
Kristine Elberg Dengsø, Jens Hillingsø, Anne Marie Marcussen, Thordis Thomsen
BACKGROUND: Cholangiocarcinoma (CCA) is a rare cancer associated with a poor prognosis. Psychosocial challenges may negatively affect daily functioning and health-related quality of life (HRQOL). The primary aim was to evaluate HRQOL, and to assess anxiety and depression in these patients. MATERIAL AND METHODS: From 93 eligible patients diagnosed with CCA, 76 were included in a prospective cohort over a period of 15 months. Patients answered the European Organization for Research and Treatment of Cancer QLQ C30 (EORTC QLQ C30) and Hospital Anxiety and Depression Scale (HADS) questionnaires at baseline, one, three and six months after initial treatment; defined as radical operation, explorative laparotomy, chemotherapy or drainage of the bile ducts...
December 31, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/28040129/efficacies-of-vitamin-d-and-omega-3-polyunsaturated-fatty-acids-on-experimental-endometriosis
#9
Alpaslan Akyol, Memet Şimşek, Raşit İlhan, Behzat Can, Melike Baspinar, Hadice Akyol, H Fatih Gül, Ferit Gürsu, Burçin Kavak, Mustafa Akın
OBJECTIVE: The aim of this study was to investigate the effects of 1,25-dihydroxyvitamin-D3 (vitamin D) and omega-3 polyunsaturated fatty acids (omega-3 PUFA) on experimentally induced endometriosis in a rat model. MATERIALS AND METHODS: A prospective, single-blind, randomized, controlled experimental study was performed on 30 Wistar female rats. Endometriosis was surgically induced by implanting endometrial tissue on the abdominal peritoneum. Four weeks later, a second laparotomy was performed to assess pre-treatment implant volumes and cytokine levels...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28040120/a-mixture-of-st-john-s-wort-and-sea-buckthorn-oils-regresses-endometriotic-implants-and-affects-the-levels-of-inflammatory-mediators-in-peritoneal-fluid-of-the-rat-a-surgically-induced-endometriosis-model
#10
Mert İlhan, İpek Süntar, Mürşide Ayşe Demirel, Erdem Yeşilada, Hikmet Keleş, Esra Küpeli Akkol
OBJECTIVE: Sea buckthorn (Hippophae rhamnoides L.) and St. John's wort (Hypericum perforatum L.) are used as an emmenagog and for the treatment of other gynecological disorders including uterus inflammation and endometriosis. The aim of the present study is to investigate the potential of a mixture of sea buckthorn and St. John's wort oils (HrHp oil) in the treatment of endometriosis. MATERIALS AND METHODS: The activity was assessed in surgically induced endometriosis in rats...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28005711/trauma-system-regionalization-improves-mortality-in-patients-requiring-trauma-laparotomy
#11
David Schechtman, Jack C He, Brenda M Zosa, Debra Allen, Jeffrey A Claridge
INTRODUCTION: This study evaluates the impact of a regional trauma network (RTN) on patient survival, intensive care unit (ICU) length of stay, and hospital length of stay in patients who required trauma laparotomy. METHODS: Patients who required trauma laparotomy from January 2008 to December 2013 were analyzed. Patients admitted during 2008-2009 and 2011-2013 were designated as pre-RTN and RTN groups, respectively. The primary outcome was mortality. RESULTS: A total of 569 patients were analyzed, 231 patients were pre-RTN, and 338 were in the RTN group...
January 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27993220/intestinal-alkaline-phosphatase-decreases-intraperitoneal-adhesion-formation
#12
Sanjiv K Hyoju, Sara Morrison, Sarah Gul, Mohammad Hadi Gharedaghi, Mohamed Mussa, Mehran Najibi, Konstantinos P Economopoulos, Sulaiman R Hamarneh, Richard A Hodin
BACKGROUND: Damage to the peritoneum initiates an inflammatory response leading to the formation of adhesions, which subsequently cause significant morbidity in some patients. Intestinal alkaline phosphatase (IAP) is a gut enzyme capable of detoxifying various inflammatory mediators such as lipopolysaccharide, lipoteichoic acid, CpG DNA, and adenosine triphosphate. In this study, we aimed to examine the anti-inflammatory effects of IAP on postoperative adhesions in mice. METHODS: C57BL/6 mice were subjected to a midline laparotomy and then six musculoperitoneal buttons (MPBs) were created by pinching and ligating the peritoneum and underlying muscle...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27984747/imaging-diagnostics-in-ovarian-cancer-magnetic-resonance-imaging-and-a-scoring-system-guiding-choice-of-primary-treatment
#13
Sigrid M Kasper, Margit Dueholm, Edvard Marinovskij, Jan Blaakær
OBJECTIVE: To analyze the ability of magnetic resonance imaging (MRI) and systematic evaluation at surgery to predict optimal cytoreduction in primary advanced ovarian cancer and to develop a preoperative scoring system for cancer staging. STUDY DESIGN: Preoperative MRI and standard laparotomy were performed in 99 women with either ovarian or primary peritoneal cancer. Using univariate and multivariate logistic regression analysis of a systematic description of the tumor in nine abdominal compartments obtained by MRI and during surgery plus clinical parameters, a scoring system was designed that predicted non-optimal cytoreduction...
October 29, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27979468/sarcopenia-in-emergency-abdominal-surgery
#14
Rebecca C Dirks, Brandy L Edwards, Elizabeth Tong, Basil Schaheen, Florence E Turrentine, Amber Shada, Philip W Smith
BACKGROUND: Sarcopenia, a loss of skeletal muscle mass associated with aging, is a practical measure of frailty and has been previously identified as a predictor of outcomes in surgical cohorts including cancer resection and elderly patients. We hypothesized that sarcopenia, as measured by preoperative computerized tomography (CT) scan, predicts mortality and morbidity in emergent laparotomy. METHODS: Institutional American College of Surgeons National Surgical Quality Improvement Program data were queried for adult patients who underwent open emergency abdominal surgery between 2008 and 2013...
January 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27956680/analgesic-efficacy-of-bilateral-continuous-transversus-abdominis-plane-blocks-using-an-oblique-subcostal-approach-in-patients-undergoing-laparotomy-for-gynaecological-cancer-a-prospective-randomized-triple-blind-placebo-controlled-study
#15
T Yoshida, K Furutani, Y Watanabe, N Ohashi, H Baba
BACKGROUND: The analgesic efficacy of continuous transversus abdominis plane (TAP) blocks in comparison with that of single-injection TAP blocks is not clear. This randomized, triple-blind, placebo-controlled trial investigated the benefits of adding continuous TAP blocks to single-injection TAP blocks after a laparotomy. METHODS: Eighty consecutive patients undergoing midline laparotomy for gynaecological cancer were randomized and received bilateral TAP infusions with either ropivacaine 0...
December 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27943594/effects-of-quercetin-and-surgicel-for-preventing-adhesions-after-gynecological-surgery-a-rat-uterine-horn-model
#16
Gürhan Güney, Cihan Kaya, Gökhan Oto, Serkan Yıldırım, Hülya Özdemir, Aytekin Tokmak
AIM: Postoperative pelvic adhesions are significant health care problems causing chronic pelvic pain, infertility and intestinal obstruction after abdominal or pelvic surgery. We investigated the effects of quercetin and Surgicel for the prevention of adhesions after gynecological surgery. METHODS: A double blind, randomized, controlled experimental study was designed. Forty female Wistar Hannover rats were divided into five groups: control, sham operated, quercetin, Surgicel, and quercetin + Surgicel...
December 12, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27909197/severity-assessment-in-rabbits-after-partial-hepatectomy-part-ii
#17
N Drude, K Pawlowsky, H Tanaka, K Fukushima, B Kögel, R H Tolba
Although the recognition of pain, distress and discomfort has already been described in 1985 by Morton and Griffiths there is still very little known about the establishment of score sheets especially, regarding post-surgical pain and severity assessment for laboratory animals such as rabbits. In this paper we describe the estimation of severity and recovery status of 36 female New Zealand White rabbits (NZW) in a standardized liver resection model using two different adhesive treatments and one control group...
December 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27899118/surgical-intervention-for-paediatric-liver-injuries-is-almost-history-a-12-year-cohort-from-a-major-scandinavian-trauma-centre
#18
Tomohide Koyama, Jorunn Skattum, Peder Engelsen, Torsten Eken, Christine Gaarder, Pål Aksel Naess
BACKGROUND: Although nonoperative management (NOM) has become standard care, optimal treatment of liver injuries in children is still challenging since many of these patients have multiple injuries. Moreover, the role of angiography remains poorly defined, and a high index of suspicion of complications is warranted. This study reviews treatment and outcomes in children with liver injuries at a major Scandinavian trauma centre over a 12-year period. METHODS: Patients <17 years old with liver injury admitted to Oslo University Hospital Ullevaal during the period 2002-2013 were retrospectively reviewed...
November 29, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27884330/factors-associated-with-adverse-events-after-emergency-laparotomy-in-cape-town-south-africa-identifying-opportunities-for-quality-improvement
#19
Richard Trafford Spence, Mark Hampton, Kent Pluke, Miriam Kahn, Nkhabe Chinyepi, Mohamed Elmusbahi, Tirsa van Wyngaard, Eugenio Panieri
BACKGROUND: Surgical outcomes research is limited in areas of the world with the greatest unmet surgical need and likely greatest variation in outcomes. Measurement alone may improve outcomes-the so-called Hawthorne effect. The purpose of this multicenter cohort study was to identify factors that are both feasible to collect and are associated with a major adverse event following a targeted procedure in Cape Town, South Africa. METHODS: A collaborative of four acute care surgical units was formed to develop a data set with minimal data burden describing outcomes after an emergency exploratory laparotomy during a 3-mo period (February-April 2015)...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884321/the-role-of-computed-tomography-after-emergent-trauma-operation
#20
Kazuhide Matsushima, Kenji Inaba, Ryan Dollbaum, Desmond Khor, Vidhi Jhaveri, Omar Jimenez, Aaron Strumwasser, Demetrios Demetriades
BACKGROUND: Although computed tomography (CT) has become the preferred diagnostic modality, immediate surgical intervention is often required for severely injured patients with minimum preoperative radiographic evaluation. The utility of postoperative CT (postop-CT) for the identification of undiagnosed injuries and its impact on patient management remain unclear. The purpose of this study was to evaluate the utility of postop-CT for the identification of clinically significant injuries in patients who underwent an emergent life-saving procedure...
December 2016: Journal of Surgical Research
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