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Mathilde Champeau, Valéria Póvoa, Lucas Militão, Flávia Cabrini, Guilherme F Picheth, Florian Meneau, Carlos P Jara, Eliana P de Araujo, Marcelo G de Oliveira
Topical nitric oxide (NO) delivery has been shown to accelerate wound healing. However, delivering NO to wounds at appropriate rates and doses requires new biomaterial-based strategies. Here, we describe the development of supramolecular interpolymer complex hydrogels comprising PEO-PPO-PEO (F127) micelles embedded in a poly(acrylic acid) (PAA) matrix, with S-nitrosoglutathione (GSNO) molecules dissolved in the hydrophilic domain. We show that PAA:F127/GSNO hydrogels start releasing NO upon hydration at rates controlled by their rates of water absorption...
May 16, 2018: Acta Biomaterialia
Cong Ma, Zhongdong Liu, Yan Qi, Shanshan Wang, Xiaolin Cao, Jing Wang, Yongxin She, Yong Shao, Jitai Shen, Chao Zhang, Zejun Jiang
In the present work, the dissipation kinetics and final residue levels of thifluzamide in the maize field ecosystem were investigated. Using a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction combined with liquid chromatography-tandem mass spectrometric detection (LC-MS/MS), a rapid, sensitive, efficient, and reliable method for extraction and quantitative analysis of thifluzamide residues in maize grain, maize plant, and soil was developed. Satisfactory recoveries of 78.7-97.0% were achieved with relative standard deviations (RSDs) in the range of 1...
May 18, 2018: Environmental Science and Pollution Research International
Martin Kočárek, Radka Kodešová, Umrbek Sharipov, Miroslav Jursík
Adjuvants are used to improve pesticides' performance. It is expected that adjuvants should increase sorption and persistence, as well as decrease mobility of pesticides in soils. Impact of the "Grounded" brand adjuvant on the behaviour of two herbicides, pendimethalin and dimethenamid-P, was investigated in a Haplic Chernozem. Both herbicides were tested in a laboratory batch sorption experiment with and without adjuvant. The sorption experiment showed that adjuvant negligibly increased dimethenamid-P sorption (KF  = 2...
April 30, 2018: Journal of Hazardous Materials
Synnøve Lofthus, Inger K Almås, Peter Evans, Oliver Pelz, Odd Gunnar Brakstad
Operational planned discharges of produced water (PW) to the marine environment from offshore oil production installations, contain low concentrations of dispersed oil compounds, like polycyclic aromatic hydrocarbons (PAHs) and alkylated phenols (APs). Biotransformation in natural seawater (SW) of naphthalenes/PAHs and phenol/APs in field-collected PW from a North Sea platform was investigated in this biodegradation study. The PW was diluted in SW from a Norwegian fjord, and the biodegradation study was performed in slowly rotating carousels at 13 °C over a period of 62 days...
May 4, 2018: Chemosphere
Kamal Awad, Maciej Banach
PURPOSE OF REVIEW: In humans, cholesterol biosynthesis varies diurnally, reaching its peak at night. Therefore, choosing the time of statin administration is critical because of their different half-lives. Dose timing becomes more important in patients with polypharmacy because it might affect their adherence to the statin therapy. RECENT FINDINGS: Herein, we narratively summarized the available clinical studies (n = 17) and meta-analyses (n = 2) that compared the morning with the evening dose of statins in terms of safety and efficacy, with special focus on their low-density lipoprotein-lowering effects...
May 15, 2018: Current Opinion in Lipidology
Lukas Graf
In the last couple of years, several extended half-life factor VIII and factor IX preparations were intensively studied and gained approval. In order to extend half-lives, techniques like fusion to protein conjugates (Fc part of IgG1 or albumin), chemical modification (PEGylation), and protein sequence modification are implemented. With these techniques, it is possible to extend half-lives of factor IX products 4- to 6- fold, while half-life extension of factor VIII products is limited to 1.5- to 2-fold due to their interaction with von Willebrand factor...
April 2018: Transfusion Medicine and Hemotherapy
Xingyue Ji, Binghe Wang
Carbon monoxide is widely acknowledged as an important gasotransmitter in the mammalian system with importance on par with that of nitric oxide. It has also been firmly established as a potential therapeutic agent with a wide range of indications including organ transplantation, cancer, bacterial infection, and inflammation-related conditions such as colitis and sepsis. One major issue in developing CO based therapeutics is its delivery in a pharmaceutically acceptable form. Currently, there are generally five forms of deliveries: inhaled CO, photosensitive CO-releasing molecules, encapsulated CO, CO dissolved in drinks, and molecules that would release CO under physiological conditions without the need for light...
May 15, 2018: Accounts of Chemical Research
Shuddhodana, Munishwar N Gupta, Virendra S Bisaria
Development of industrially potent cellulolytic enzymes is one of the greatest challenges faced in lignocellulosic feed-stock based bio-refining. In the current work cross-linked enzyme aggregates (CLEAs) of commercial cellulase mix were successfully prepared and their performance to be used as potential industrial enzymes in terms of stability and wheat straw hydrolysis was evaluated. The CLEAs were more stable compared to native enzymes with half-lives being 2.30-, 1.56-, 3.07- and 1.67-fold higher at 70°C for filter paper activity (FPA), endoglucanase, β-glucosidase and xylanase, respectively...
May 11, 2018: Journal of Bioscience and Bioengineering
Linke Ge, Crispin Halsall, Chang-Er Chen, Peng Zhang, Qianqian Dong, Ziwei Yao
Fluoroquinolone antibiotics (FQs) are ubiquitous and ionisable in surface waters. Here we investigate gatifloxacin (GAT) and balofloxacin (BAL), two widely used FQs, and determine the photochemical reactivity of their respective dissociation species that arise at different pH to understand the relevance and pathways of phototransformation reactions. Simulated-sunlight experiments and matrix calculations showed that neutral forms (HFQs0 ) of the two antibiotics had the highest apparent photolytic efficiency and hydroxyl-radical oxidation reactivity...
August 15, 2018: Science of the Total Environment
Chang-Gui Pan, Feng-Jiao Peng, Guang-Guo Ying
Climbazole (CBZ) is an antibacterial and antifungal agent widely used in personal care products. In this study, we investigated the interactions between climbazole (CBZ) and freshwater microalgae Scenedesmus obliquus (S. obliquus). Dose-effect relationships between CBZ concentrations and growth inhibitions or chlorophyll a content were observed. After 12 days of incubation, the algae density and chlorophyll a content in 2 mg/L treatment group was 56.6% and 15.8% of those in the control group, respectively...
May 11, 2018: Environmental Pollution
Hirokazu Miyatake, Nobuaki Yoshizawa, Gen Suzuki
The Fukushima Daiichi Nuclear Power Plant (FDNPP) accident resulted in a release of radionuclides into the environment. Since the accident, measurements of radiation in the environment such as air dose rate and deposition density of radionuclides have been performed by various organizations and universities. In particular, Japan Atomic Energy Agency (JAEA) has been performing observations of air dose rate using a car-borne survey system continuously over widespread areas. Based on the data measured by JAEA, we estimated effective dose from external exposure in the prefectures surrounding Fukushima...
May 11, 2018: Radiation Protection Dosimetry
Florence Amblard, Françoise Devillard, Léa Dumortier, Véronique-Aurélie Bricout
The life expectancy of people with trisomy 21 has increased over recent decades. More than half live over 55 years today, compared to just 9 years in 1929. This progress is thanks to easier access to care and improved medical diagnoses as well as greater physical and psychological stimulation. Continued monitoring remains essential but it becomes less systematic as children grow up, despite the risk of certain complications increasing from puberty. Consultations devoted to trisomy 21 aim to facilitate access to care through an adapted care pathway...
May 2018: Soins. Pédiatrie, Puériculture
Josefina Del Brio, Cristina Mónica Montagna, Betsabé Ailén Lares, María Eugenia Parolo, Andrés Venturino
Chemical and toxicological crude oil analysis was performed on water-accommodated fraction of oil (WAF). This study characterized the chemical composition of WAF and its dissipation over a period of 192 h. Acute (96 h) and chronic (14 d) toxicity of WAF were evaluated on Hyalella curvispina from both reference (Los Barreales lake, LB) and hydrocarbon-contaminated (Durán stream, DS) sites. The total hydrocarbon (TPHs) concentration in WAF was 2.18 mg L-1 . The dissipation rates of hydrocarbons in WAF showed a first-order kinetics, with half-lives ranging between 65 h-200 h...
April 30, 2018: Environmental Toxicology and Pharmacology
R Marlu, P Malvezzi, L Seyve, T Jouve, J Maurizi, F Defendi, P L Carron, M Christophe, A Le Gouellec, B Polack, L Rostaing
INTRODUCTION: Donor-specific alloantibodies (DSAs) cause kidney-allograft loss in chronic antibody-mediated rejection (CAMR). Treatment relies on blocking antibody-producing cells and removing DSAs by apheresis: e.g., double-filtration plasmapheresis (DFPP). MATERIALS AND METHODS: To determine the impact of DFPP (6 or 8 sessions/patient) on clotting factors and natural anticoagulants, and on thrombin generation, we performed a prospective and observational study in five CAMR kidney-transplant patients who received DFPP plus rituximab therapy...
April 20, 2018: Thrombosis Research
Bidyadhar Sethy, Chung-Fan Hsieh, Chieh Yeh, Jim-Tong Horng, Pei-Wen Hsieh
AIM: No antiviral medications are currently approved to treat enterovirus (EV)-associated disease or prevent EV infection. METHODS: In this study, a series of probenecid derivatives were designed via a rational strategy and synthesized to obtain more potent anti-EV agents. RESULTS: Compounds 8 and 24 exhibited the most potent activity against EV D68 and A71, with half maximal effective concentration (EC50 ) values of 2.49/2.09 and 2.59/2.41 μM, respectively, and revealed a broad inhibition spectrum toward other EV strains, with high selectivity indices...
May 10, 2018: Future Medicinal Chemistry
Jana Fechner, Martin Kaufmann, Corinna Herz, Daniela Eisenschmidt, Evelyn Lamy, Lothar W Kroh, Franziska S Hanschen
Rocket is rich in glucosinolates and valued for its hot and spicy taste. Here we report the structure elucidation, bioactivity, and stability of the mainly formed glucosinolate hydrolysis product, namely sativin, which was formerly thought to be 4-mercaptobutyl isothiocyanate. However, by NMR characterization we revealed that sativin is in fact 1,3-thiazepane-2-thione, a tautomer of 4-mercaptobutyl isothiocyanate with 7-membered ring structure and so far unknown. This finding was further substantiated by conformation sampling using molecular modeling and total enthalpy calculation with density functional theory...
September 30, 2018: Food Chemistry
Mohammad A Rai, Sam Pannek, Carl J Fichtenbaum
There are 36.7 million people living with HIV with 20.9 million having access to antiretroviral therapy (ART). Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) remain the 'backbone' of ART. However, the currently available nine NRTIs and five non-nucleoside reverse transcriptase inhibitors (NNRTIs) have significant side effects and resistance profiles. Areas covered: We summarize the mechanisms of resistance and other limitations of the existing NRTIs/NNRTIs. GS-9131, MK-8591, Elsulfavirine and Doravirine are four new agents that are furthest along in development...
May 8, 2018: Expert Opinion on Emerging Drugs
Olalla López-Fernández, Eva Pose-Juan, Remedios Yáñez, Raquel Rial-Otero, Jesús Simal-Gándara
Five photodegradation products of metrafenone (MTF) and six of mepanipyrim (MEP) were identified in synthetic grape juice at 25 °C and the structures of the main reaction products established. The degradation of MTF and MEP was modelled by using three different strategies involving monitoring (a) the disappearance of the parent compound, (b) the conversion of the parent compound into its main structurally related reaction products and (c) the degradation of the parent compound to all intermediates and degradation end-products...
June 2018: Food Research International
Alyson R Ribeiro, Bernd Sures, Torsten C Schmidt
The release of antibiotics into the environment may lead to deleterious effects in non-target organisms as well as pressure in antimicrobial resistance acquirement. Ceftiofur (CEF) and cefapirin (CEPA) are veterinary cephalosporins used for recurrent and economically relevant infections. Both antibiotics have been detected in aquatic environments and their fate during drinking water processing is still unknown. This work investigated the acute and chronic toxicities of CEF and CEPA towards aquatic organisms including stability tests...
April 1, 2018: Science of the Total Environment
Duoduo Jiang, Lifang Duan, Runan Li, Xinglu Pan, Yan Tao, Xiaohu Wu, Jun Xu, Xingang Liu, Fengshou Dong, Yongquan Zheng
Wax gourd is a popular vegetable and the new organic copper pesticide product of copper nonylphenolsulfonate and hexaconazole was firstly recommended to control the serious disease powdery mildew frequently occurred in wax gourd. However, it is still a concern for data deficiency of residue amounts of these two pesticides in edible portion of wax gourd and the persistence in environment. In this study, the dissipation and residue of copper nonylphenolsulfonate and hexaconazole in wax gourd and soil were investigated...
May 3, 2018: Ecotoxicology and Environmental Safety
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