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JOURNAL ARTICLE
Remy S Petersen, Lauré M Fijen, Christian Apfelbacher, Markus Magerl, Karsten Weller, Werner Aberer, Adil Adatia, Paul Audhya, Noémi-Anna Bara, Stephen Betschel, Isabelle Boccon-Gibod, Laurence Bouillet, Nicholas Brodszki, Paula J Busse, Thomas Buttgereit, Anette Bygum, Mauro Cancian, Timothy Craig, Dorottya Csuka, Henriette Farkas, Daria Fomina, Johana Gil-Serrano, Mark Gompels, Guillermo Guidos Fogelbach, Mar Guilarte, Michihiro Hide, Sorena Kiani-Alikhan, Tamar Kinaciyan, Annet Lenten, Ramon Lleonart, Hilary Longhurst, William R Lumry, Alejandro Malbran, Laura Malinauskiene, Juan J Matta Campos, Joan Mendivil, Sandra A Nieto-Martinez, Jonathan G Peter, Grzegorz Porebski, Avner Reshef, Marc Riedl, Anna Valerieva, Susan Waserman, Marcus Maurer, Danny M Cohn
BACKGROUND: Clinical trials investigating drugs for acute treatment of hereditary angioedema attacks have assessed many different outcomes. This heterogeneity limits comparability of trial results and may lead to selective outcome reporting bias and a high burden on trial participants. OBJECTIVE: To achieve consensus on a Core Outcome Set comprising key outcomes that should ideally be utilized in all clinical efficacy trials involving acute treatment of hereditary angioedema attacks...
April 10, 2024: Journal of Allergy and Clinical Immunology in Practice
#22
JOURNAL ARTICLE
Enrique Dorronzoro-Zubiete, Jesús Castro-Marrero, Jorge Ropero, José Luis Sevillano-Ramos, María Dolores Hernández, Ramon Sanmartin Sentañes, Jose Alegre-Martin, Patricia Launois-Obregón, Isabel Martin-Garrido, Asuncion Luque Budia, Juan R Lacalle-Remigio, Luis Béjar Prado, Octavio Rivera Romero
BACKGROUND: Fatigue is the most common symptom in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID, impacting patients' quality of life; however, there is currently a lack of evidence-based context-aware tools for fatigue self-management in these populations. OBJECTIVE: This study aimed to (1) address fatigue in ME/CFS and long COVID through the development of digital mobile health solutions for self-management, (2) predict perceived fatigue severity using real-time data, and (3) assess the feasibility and potential benefits of personalized digital mobile health solutions...
April 12, 2024: JMIR Research Protocols
#23
JOURNAL ARTICLE
Winston Dunn, Yanming Li, Ashwani K Singal, Douglas A Simonetto, Luis A Díaz, Francisco Idalsoaga, Gustavo Ayares, Jorge Arnold, María Ayala-Valverde, Diego Perez, Jaime Gomez, Rodrigo Escarate, Eduardo Fuentes-López, Carolina Ramirez-Cadiz, Dalia Morales-Arraez, Wei Zhang, Steve Qian, Joseph C Ahn, Seth Buryska, Heer Mehta, Nicholas Dunn, Muhammad Waleed, Horia Stefanescu, Andreea Bumbu, Adelina Horhat, Bashar Attar, Rohit Agrawal, Joaquín Cabezas, Victor Echavaría, Berta Cuyàs, Maria Poca, German Soriano, Shiv K Sarin, Rakhi Maiwall, Prasun K Jalal, Fátima Higuera-de-la-Tijera, Anand V Kulkarni, P Nagaraja Rao, Patricia Guerra-Salazar, Lubomir Skladaný, Natália Kubánek, Veronica Prado, Ana Clemente-Sanchez, Diego Rincon, Tehseen Haider, Kristina R Chacko, Gustavo A Romero, Florencia D Pollarsky, Juan C Restrepo, Luis G Toro, Pamela Yaquich, Manuel Mendizabal, Maria L Garrido, Sebastián Marciano, Melisa Dirchwolf, Victor Vargas, César Jiménez, David Hudson, Guadalupe García-Tsao, Guillermo Ortiz, Juan G Abraldes, Patrick S Kamath, Marco Arrese, Vijay H Shah, Ramon Bataller, Juan P Arab
BACKGROUND AIMS: Alcohol-associated hepatitis (AH) poses significant short-term mortality. Existing prognostic models lack precision for 90-day mortality. Utilizing artificial intelligence (AI) in a global cohort, we sought to derive and validate an enhanced prognostic model. APPROACH AND RESULTS: The Global AlcHep initiative, a retrospective study across 23 centers in 12 countries, enrolled AH patients per NIAAA criteria. Centers were partitioned into derivation (11 centers, 860 patients) and validation cohorts (12 centers, 859 patients)...
April 12, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#24
JOURNAL ARTICLE
Mauricio Andrade-Marcial, Ramón Pacheco-Arjona, Sara Hernández-Castellano, Ligia Che-Aguilar, Clelia De-la-Peña
Albino plants display partial or complete loss of photosynthetic pigments and defective thylakoid membrane development, consequently impairing plastid function and development. These distinctive attributes render albino plants excellent models for investigating chloroplast biogenesis. Despite their potential, limited exploration has been conducted regarding the molecular alterations underlying these phenotypes, extending beyond photosynthetic metabolism. In this study, we present a novel de novo transcriptome assembly of an albino somaclonal variant of Agave angustifolia Haw...
2024: Physiologia Plantarum
#25
JOURNAL ARTICLE
Ramon Antunes De Oliveira, Vinicius Oliveira Pesquero, Lucas Zago Ribeiro, Murilo Ubukata Polizelli, Aalec Rinhel Souza Ferreira Da Silva, Nilva Simeren Bueno De Moraes, Rodrigo Antonio Brant Fernandes, Octaviano Magalhaes Junior, Mauricio Maia
BACKGROUND: Describe complications and clinical outcomes of heavy silicone oil (HSO) Oxane HD® use as an alternative to overcome the challenges of performing vitrectomy to treat tractional and rhegmatogenous retinal detachments with proliferative vitreoretinopathy (PVR). METHODS: A retrospective, observational study was performed on patients from one center from August 2014 to Aug 2023. It was included patients who underwent surgery using HSO Oxane HD® to treat rhegmatogenous retinal detachment with PVR or mixed tractional and rhegmatogenous diabetic retinal detachment...
April 11, 2024: International Journal of Retina and Vitreous
#26
JOURNAL ARTICLE
Jessie García-Fleitas, Alba García-Fernández, Vicente Martí-Centelles, Félix Sancenón, Andrea Bernardos, Ramón Martínez-Máñez
ConspectusCellular senescence can be defined as an irreversible stopping of cell proliferation that arises in response to various stress signals. Cellular senescence is involved in diverse physiological and pathological processes in different tissues, exerting effects on processes as differentiated as embryogenesis, tissue repair and remodeling, cancer, aging, and tissue fibrosis. In addition, the development of some pathologies, aging, cancer, and other age-related diseases has been related to senescent cell accumulation...
April 11, 2024: Accounts of Chemical Research
#27
JOURNAL ARTICLE
Georgina Ferret, Manel Cremades, Lídia Cornejo, Francesc Guillem-López, Ramon Farrés, David Parés, Joan-Francesc Julian
INTRODUCTION: Innovation in internet connectivity and the Covid 19 pandemic have caused a dramatic change in the management of patients in the medical field, boosting the use of telemedicine. A comparison of clinical outcomes and satisfaction between conventional face-to-face and telemedicine follow-up in general surgery, an economic evaluation is mandatory. The aim of the present study was to compare the differences in economic costs between these two outpatient approaches in a designed randomized controlled trial (RCT)...
April 9, 2024: Cirugia española
#28
JOURNAL ARTICLE
Ivan Cherrez-Ojeda, Jean Bousquet, Ana Giménez-Arnau, Kiran Godse, Dorota Krasowska, Joanna Bartosińska, Paulina Szczepanik-Kułak, Bartłomiej Wawrzycki, Pavel Kolkhir, Anastasiia Allenova, Andrey Allenov, Sergey Tkachenko, Natasa Teovska Mitrevska, Dragan Mijakoski, Sasho Stoleski, Marta Kolacinska-Flont, Izabela Kuprys-Lipinska, Joanna Molinska, Alicja Kasperska-Zając, Magdalena Zajac, Mateusz Zamlynski, Florin Mihaltan, Ruxandra Ulmeanu, Anna Zalewska-Janowska, Katarzyna Tomaszewska, Mona Al-Ahmad, Maryam Ali Al-Nesf, Tayseer Ibrahim, Sami Aqel, David Pesqué, Mónica Rodríguez-González, Guillermo Hideo Wakida-Kuzunoki, German D Ramon, Gonzalo N Ramon, Sophia Neisinger, Hanna Bonnekoh, Maia Rukhadze, Maryam Khoshkhui, Daria Fomina, Désirée Larenas-Linnemann, Mitja Košnik, Rabia Oztas Kara, Chrystopherson Gengyny Caballero López, Qiang Liu, Carlos Ivancevich Juan, Luis Felipe Ensina, Nelson Rosario, Violeta Kvedariene, Moshe Ben-Shoshan, Roberta Fachini Jardim Criado, Andrea Bauer, Annia Cherrez, Herberto Chong-Neto, Maria Isabel Rojo-Gutierrez, Michael Rudenko, José Ignacio Larco Sousa, Aleksandra Lesiak, Edgar Matos, Nelson Muñoz, Ivan Tinoco, Jaime Moreno, Carolina Crespo Shijin, Romina Hinostroza Logroño, Juan C Sagñay, Marco Faytong-Haro, Karla Robles-Velasco, Torsten Zuberbier, Marcus Maurer
BACKGROUND: Patient-reported outcome measures (PROMs) are validated and standardized tools that complement physician evaluations and guide treatment decisions. PROMs are crucial for monitoring atopic dermatitis (AD) and chronic urticaria (CU) in clinical practice, but there are unmet needs and knowledge gaps regarding their use in clinical practice. OBJECTIVE: We investigated the global real-world use of AD and CU PROMs in allergology and dermatology clinics as well as their associated local and regional networks...
April 9, 2024: Journal of Allergy and Clinical Immunology in Practice
#29
JOURNAL ARTICLE
José Ramón Vázquez-Díaz
Family and Community Medicine is the most offered and chosen specialty in the MIR (Spanish medical residency examination), however, every year its attractiveness is questioned due to not all offered positions being filled and a certain number of resident doctors deciding not to continue in this specialty once started. In this context, some of the proposals to address the problem focus on increasing the supply when the facts show that the challenge lies in addressing the demand by making the specialty and its professional scope more attractive...
April 10, 2024: Atencion Primaria
#30
COMMENT
Ramon Massana
A bacterial endosymbiont of marine algae evolved to an organelle.
April 12, 2024: Science
#31
JOURNAL ARTICLE
Sarah A Naudin, Aude A Ferran, Pedro Henrique Imazaki, Nathalie Arpaillange, Camille Marcuzzo, Maïna Vienne, Sofia Demmou, Alain Bousquet-Mélou, Felipe Ramon-Portugal, Marlene Z Lacroix, Claire Hoede, Maialen Barret, Véronique Dupouy, Delphine Bibbal
Sewer biofilms are likely to constitute hotspots for selecting and accumulating antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs). This study aimed to optimize culture conditions to obtain in vitro biofilms, mimicking the biofilm collected in sewers, to study the impact of fluoroquinolones (FQs) on sewer biofilm microbiota. Biofilms were grown on coupons in CDC Biofilm Reactors®, continuously fed with nutrients and inoculum (1/100 diluted wastewater). Different culture conditions were tested: (i) initial inoculum: diluted wastewater with or without sewer biofilm, (ii) coupon material: concrete vs...
2024: Frontiers in Microbiology
#32
JOURNAL ARTICLE
John J McCabe, Cathal Walsh, Sarah Gorey, Katie Harris, Pablo Hervella, Ramon Iglesias-Rey, Christina Jern, Linxin Li, Nobukazu Miyamoto, Joan Montaner, Annie Pedersen, Francisco Purroy, Peter M Rothwell, Catherine Sudlow, Yuji Ueno, Mikel Vicente-Pascual, William Whiteley, Mark Woodward, Peter J Kelly
INTRODUCTION: Inflammation is an emerging target for secondary prevention after stroke and randomised trials of anti-inflammatory therapies are ongoing. Fibrinogen, a putative pro-inflammatory marker, is associated with first stroke, but its association with major adverse cardiovascular events (MACE) after stroke is unclear. MATERIALS AND METHODS: We did a systematic review investigating the association between fibrinogen and post-stroke vascular recurrence. Authors were invited to provide individual-participant data (IPD) and where available we did within-study multivariable analyses with adjustment for cardiovascular risk factors and medications...
April 10, 2024: European Stroke Journal
#33
JOURNAL ARTICLE
Joan Carles Domingo, Federica Battistini, Begoña Cordobilla, Maria Cleofé Zaragozá, Ramón Sanmartin-Sentañes, Jose Alegre-Martin, Trinitat Cambras, Jesus Castro-Marrero
BACKGROUND: Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID. However, there is limited knowledge regarding their potential association with circulating biomarkers and illness severity in these conditions. METHODS: This single-site, prospective, cross-sectional, pilot cohort study aimed to distinguish between the two patient populations by using self-reported outcome measures and circulating biomarkers of endothelial function and systemic inflammation status...
April 10, 2024: Journal of Translational Medicine
#34
JOURNAL ARTICLE
Pratiksha B Gaikwad, Taewon D Kim, M Richer, Rugwed A Lokhande, Gabriela Sánchez-Díaz, Peter A Limacher, Paul W Ayers, Ramón Alain Miranda-Quintana
Electron pairs have an illustrious history in chemistry, from powerful concepts to understanding structural stability and reactive changes to the promise of serving as building blocks of quantitative descriptions of the electronic structure of complex molecules and materials. However, traditionally, two-electron wavefunctions (geminals) have not enjoyed the popularity and widespread use of the more standard single-particle methods. This has changed recently, with a renewed interest in the development of geminal wavefunctions as an alternative to describing strongly correlated phenomena...
April 14, 2024: Journal of Chemical Physics
#35
JOURNAL ARTICLE
Javier Asensio-Salazar, Alvaro Rivero Calle, Eduardo Olavarría Montes, Alejandro Delgado Fernández, Ignacio Zubillaga Rodríguez, Ramon Gutiérrez Díaz, Gregorio Sánchez Aniceto
Virtual surgical planning (VSP) and three-dimensional (3D) printing can increase precision and reduce surgical time in craniofacial reconstruction. However, the elevated cost and manufacturing time of outsourced workflows is increasing the development of in-house solutions. One of the main challenges in in-house workflows is to create cutting guides that hold plate position information. This is due to the fact that hospitals usually lack the infrastructure required to design and 3D print custom-made plates...
April 2024: Plastic and Reconstructive Surgery. Global Open
#36
REVIEW
Juraj Szavits-Nossan, Ramon Grima
Stochastic models of gene expression are typically formulated using the chemical master equation, which can be solved exactly or approximately using a repertoire of analytical methods. Here, we provide a tutorial review of an alternative approach based on queueing theory that has rarely been used in the literature of gene expression. We discuss the interpretation of six types of infinite server queues from the angle of stochastic single-cell biology and provide analytical expressions for the stationary and non-stationary distributions and/or moments of mRNA/protein numbers, and bounds on the Fano factor...
April 8, 2024: Biophysical Journal
#37
JOURNAL ARTICLE
Lucía Lozano-Vicario, Fabiola Zambom-Ferraresi, Fabricio Zambom-Ferraresi, Mikel L Sáez de Asteasu, Arkaitz Galbete-Jiménez, Ángel Javier Muñoz-Vázquez, Bernardo Abel Cedeno-Veloz, Antón De la Casa-Marín, Iranzu Ollo-Martínez, Joaquín Fernández-Irigoyen, Enrique Santamaría, Ramón San Miguel Elcano, José Ramón Ortiz-Gómez, Román Romero-Ortuño, Mikel Izquierdo, Nicolás Martínez-Velilla
OBJECTIVE: Delirium is a serious neuropsychiatric syndrome frequently occurring in hospitalized older adults, for which pharmacological treatments have shown limited effectiveness. Multicomponent physical exercise programs have demonstrated functional benefits; however, the impact of exercise on the course of delirium remains unexplored. The aim of this study was to investigate the effect of an individualized, multicomponent exercise intervention on the evolution of delirium and patient outcomes...
April 6, 2024: Journal of the American Medical Directors Association
#38
JOURNAL ARTICLE
Prediction of attention deficit hyperactivity disorder based on explainable artificial intelligence.
Ignasi Navarro-Soria, Juan Ramón Rico-Juan, Rocio Juárez-Ruiz de Mier, Rocío Lavigne-Cervan
Accurate assessment of Attention Deficit Hyperactivity Disorder (ADHD) is crucial for the effective treatment of affected individuals. Traditionally, psychometric tests such as the WISC-IV have been utilized to gather evidence and identify patterns or factors contributing to ADHD diagnosis. However, in recent years, the use of machine learning (ML) models in conjunction with post-hoc eXplainable Artificial Intelligence (XAI) techniques has improved our ability to make precise predictions and provide transparent explanations...
April 9, 2024: Applied Neuropsychology. Child
#39
JOURNAL ARTICLE
Helga Cecília Muniz de Souza, Maíra Florentino Pessoa, Rafaela Dos Santos Clemente, Alanna Vasconcelos da Silva, Pablo Ramon Gualberto Cardoso, Juliana Fernandes, Arméle Dornelas de Andrade
AIM: to investigate the effects of the whole body vibration (WBV) and inspiratory muscle training (IMT) on the inflammatory profile and in muscle mass and strength in pre-frail older women. METHODS: this study was a randomized double-blind trial. Forty two older women aged 60-80 years were randomly allocated to IMT + WBV (G1), IMTsham + WBV (G2) or Sham groups (G3). During 12 weeks G1 received both trainings, whereas G2 received WBV alone and G3 received IMT with a low fixed load and were positioned at the vibratory platform without therapeutic effect...
March 24, 2024: Archives of Gerontology and Geriatrics
#40
JOURNAL ARTICLE
Patrícia Sousa, Catarina Brás, Catarina Menezes, Ramon Vizcaino, Teresa Costa, Maria Sameiro Faria, Conceição Mota
INTRODUCTION: Percutaneous kidney biopsy (KB) is crucial to the diagnosis and management of several renal pathologies. National data on native KB in pediatric patients are scarce. We aimed to review the demographic and clinical characteristics and histopathological patterns in children who underwent native percutaneous KB over 24 years. METHODS: Retrospective observational study of patients undergoing native percutaneous KB in a pediatric nephrology unit between 1998 and 2021, comparing 3 periods: period 1 (1998-2005), period 2 (2006-2013), and period 3 (2014-2021)...
2024: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
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