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Almudena Pérez-Rodríguez, Javier Batlle, Irene Corrales, Nina Borràs, Ángela Rodríguez-Trillo, Esther Lourés, Ana Rosa Cid, Santiago Bonanad, Noelia Cabrera, Andrés Moret, Rafael Parra, María Eva Mingot-Castellano, Nira Navarro, Carmen Altisent, Rocío Pérez-Montes, Shally Marcellini, Ana Moreto, Sonia Herrero, Inmaculada Soto, Nuria Fernández Mosteirín, Víctor Jiménez-Yuste, Nieves Alonso, Aurora de Andrés Jacob, Emilia Fontanes, Rosa Campos, María José Paloma, Nuria Bermejo, Rubén Berrueco, José Mateo, Karmele Arribalzaga, Pascual Marco, Ángeles Palomo, Nerea Castro Quismondo, Belén Iñigo, María Del Mar Nieto, Rosa Vidal, María Paz Martínez, Reyes Aguinaco, Maria Tenorio, María Ferreiro, Javier García-Frade, Ana María Rodríguez-Huerta, Jorge Cuesta, Ramón Rodríguez-González, Faustino García-Candel, Manuela Dobón, Carlos Aguilar, Fernando Batlle, Francisco Vidal, María Fernanda López-Fernández
The multimeric analysis (MA) of plasma von Willebrand factor (VWF) evaluates structural integrity and helps in the diagnosis of von Willebrand disease (VWD). This assay is a matter of controversy, being considered by some investigators cumbersome and only slightly informative. The centralised study 'Molecular and Clinical Profile of von Willebrand Disease in Spain (PCM-EVW-ES)' has been carried out by including the phenotypic assessment and the genetic analysis by next generation sequencing (NGS) of the VWF gene (VWF)...
2018: PloS One
Martha Elba Alarcón, María Del Refugio López, Magali Ramon, Irma Rosa Alvarado, Martha González
The aim of this study was to identify the maternal feeding practices with children who have some kind of disability and its influence in their social inclusion process. Three focus groups were carried out with the participation of twelve mothers/caregivers of children with disabilities. The mothers/caregivers are in charge of their children's progress with respect to their physical health and disability. Their feeding practices contribute to their health condition, to the acquisition of nourishing learning, social behavior at the table, domestic collaboration, as well as to the development of language by means of the communicative interactions, and also the tightening of the affective bond between mother and child...
January 2018: Revista Peruana de Medicina Experimental y Salud Pública
Pilar Ramon Pardo, Hatim Sati, Marcelo Galas
Antimicrobial resistance is a complex epidemiology problem worldwide which calls for a wide and integrated approach such as "One Health." Resistant organisms are present in humans, animals, food, and the environment, and the main impeller of this resistance is the use of antimicrobial agents. The occurrence and propagation of antimicrobial resistance continue incessantly in the world, leaving devastating economic and health consequences behind. In 2015, the WHO, in collaboration with key partners such as the FAO and the OIE, developed the World Action Plan in Antimicrobial Resistance, under the perspective of "One Health...
January 2018: Revista Peruana de Medicina Experimental y Salud Pública
Nicolas Cesário Pereira, Evandro Ribeiro Diniz, Ramon Coral Ghanem, Ruy Cunha Filho, Tatiana Moura Prazeres, Walton Nose, Adriana Dos Santos Forseto
PURPOSE: This report describes the use of Descemet membrane endothelial keratoplasty for the management of endothelial decompensation after multifocal intraocular lens implantation. METHODS: In this retrospective study, we reviewed and assessed the surgical outcomes of 9 patients (9 eyes) who underwent Descemet membrane endothelial keratoplasty after multifocal intraocular lens implantation. RESULTS: Corneal edema occurred due to Fuchs endothelial corneal dystrophy (n=3), pseudophakic bullous keratopathy (n=3), Descemet's membrane detachment (n=2), and toxic anterior segment syndrome (n=1)...
June 2018: Arquivos Brasileiros de Oftalmologia
Andrea Moneo-Corcuera, David Nieto-Castro, Cristina Sáenz de Pipaón, Verónica Gómez, Pilar Maldonado-Illescas, Jose Ramon Galan-Mascaros
The magnetic behavior of the polyanion [Fe3(μ-L)6(H2O)6]6- (L2- = (1,2,4-triazol-4-yl)ethanedisulfonate) as the corresponding dimethylammonium salt shows memory effect above room temperature, with a dynamic thermal hysteresis cycle over 90 K and temperature-induced excited spin state trapping (TIESST) phenomena at the highest temperatures reported. Taking advantage of the polyanionic nature of this trimetallic complex, we were able to substitute the dimethylammonium cations by the monovalent heavy alkali metal cesium...
June 20, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Neibla Priego, Lucía Zhu, Cátia Monteiro, Manon Mulders, David Wasilewski, Wendy Bindeman, Laura Doglio, Liliana Martínez, Elena Martínez-Saez, Santiago Ramón Y Cajal, Diego Megías, Elena Hernández-Encinas, Carmen Blanco-Aparicio, Lola Martínez, Eduardo Zarzuela, Javier Muñoz, Coral Fustero-Torre, Elena Piñeiro-Yáñez, Aurelio Hernández-Laín, Luca Bertero, Valeria Poli, Melchor Sanchez-Martinez, Javier A Menendez, Riccardo Soffietti, Joaquim Bosch-Barrera, Manuel Valiente
In the version of this article originally published, the names of three authors were incorrect. The authors were listed as "Coral Fustero-Torres", "Elena Pineiro" and "Melchor Sánchez-Martínez". Their respective names are "Coral Fustero-Torre", "Elena Piñeiro-Yáñez" and "Melchor Sanchez-Martinez". The errors have been corrected in the print, HTML and PDF versions of this article.
June 19, 2018: Nature Medicine
Ramón Elizondo-Romo, Jorge Adrián Nuñez-Zuno, Iván Josué Jiménez-González, Emiliano Montiel-Nuñez, José Víctor Jiménez, Diego Luis Carrillo-Pérez
No abstract text is available yet for this article.
June 19, 2018: Postgraduate Medical Journal
María José Moreno, Alberto Gallardo, Silvana Novelli, Ana Mozos, Marc Aragó, Miguel Ángel Pavón, María Virtudes Céspedes, Víctor Pallarès, Aïda Falgàs, Miguel Alcoceba, Oscar Blanco, Marcos Gonzalez-Díaz, Jorge Sierra, Ramon Mangues, Isolda Casanova
The CXCR4/CXCL12 axis has been extensively associated with different types of cancer correlating with higher aggressiveness and metastasis. In diffuse large B-cell lymphoma (DLBCL), the expression of the chemokine receptor CXCR4 is involved in the dissemination of malignant B cells and is a marker of poor prognosis. CXCR7 is a chemokine receptor that binds to the same ligand as CXCR4 and regulates de CXCR4-CXCL12 axis. These findings together with the report of CXCR7 prognostic value in several tumor types, led us to evaluate the expression of CXCR7 in diffuse large B-cell lymphoma biopsies...
2018: PloS One
Ramon Sanchez-Ocana, Irene Penas-Herrero, Paula Gil-Simon, Carlos de la Serna-Higuera, Manuel Perez-Miranda
No abstract text is available yet for this article.
December 2017: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Leonard Katz, Yvonne Y Chen, Ramon Gonzalez, Todd C Peterson, Huimin Zhao, Richard H Baltz
Synthetic biology is a logical extension of what has been called recombinant DNA (rDNA) technology or genetic engineering since the 1970s. As rDNA technology has been the driver for the development of a thriving biotechnology industry today, starting with the commercialization of biosynthetic human insulin in the early 1980s, synthetic biology has the potential to take the industry to new heights in the coming years. Synthetic biology advances have been driven by dramatic cost reductions in DNA sequencing and DNA synthesis; by the development of sophisticated tools for genome editing, such as CRISPR/Cas9; and by advances in informatics, computational tools, and infrastructure to facilitate and scale analysis and design...
June 18, 2018: Journal of Industrial Microbiology & Biotechnology
Ramón Ruiz Mesa, Tiago Monteiro
Presbyopia is a condition that affects many as the lens ages, and is a secondary effect of cataract surgery. Multifocal lenses for the treatment of presbyopia have been undergoing cycles of development and improvement over the past two decades. The latest advancements have yielded lenses with a continuous range of optical powers, otherwise known as continuous transitional focus (CTF) lenses. Modern CTF lenses provide a more natural experience for patients while minimizing unwanted optical side effects.
June 18, 2018: Ophthalmology and Therapy
Chiara D'Angelo, Marcella Reale, Erica Costantini, Marta Di Nicola, Italo Porfilio, Clara de Andrés, Lidia Fernández-Paredes, Silvia Sánchez-Ramón, Livia Pasquali
Background: Multiple sclerosis (MS) is a chronic, progressive autoimmune disease of the central nervous system in which inflammation plays a key role in the induction, development, and progression. Most of the MS patients present with relapsing-remitting (RR) form, characterized by flare-ups followed by periods of recovery. Many inflammatory and anti-inflammatory cytokines have been proposed as backers in MS pathogenesis, and the balance between these differing cytokines can regulate MS severity...
2018: Frontiers in Immunology
Manuel Hernández Salazar, Antonio Zarate Méndez, Oscar Meneses Luna, Lucía Ledesma Torres, Ramón Paniagua Sierra, Mary Carmen Sánchez Moreno, Juan Leonardo Serrato Avila
INTRODUCTION AND OBJECTIVES: The irreducible neuroaggressive disorder (IND) is a well-described entity known to be associated with impulsive and aggressive behavior. While various studies have assessed available pharmacological and non-pharmacological treatment regimens, patients with IND continue to pose a major threat to themselves and society. While targeted stereotactic therapy for IND has gained traction in recent years, there is a paucity of information describing comparative effectiveness of different validated anatomic regions...
June 15, 2018: Neurocirugía
Richard Moreau, Ramon Bataller, Thomas Berg, Jessica Zucman-Rossi, Rajiv Jalan
No abstract text is available yet for this article.
July 2018: Journal of Hepatology
Angel Josabad Alonso-Castro, Juan Ramón Zapata-Morales, Victor Arana-Argáez, Julio Cesar Torres-Romero, Eyra Ramírez-Villanueva, Sabino Eduardo Pérez-Medina, Marco Antonio Ramírez-Morales, Mario Alberto Juárez-Méndez, Yessica Paola Infante-Barrios, Fidel Martínez-Gutiérrez, Candy Carranza-Álvarez, Mario Alberto Isiordia-Espinoza, Andrés Flores-Santos
Eysenhardtia polystachya is used for the empirical treatment of cancer, infections, diarrhea, inflammation, and pain. This study identified, using GC-MS, the main chemical components in an ethanol extract of E. polystachya branches and leaves (EPE) and tested its cytotoxic, antimicrobial, anti-diarrheal, anti-inflammatory, and antinociceptive effects. The in vitro and in vivo toxicity of EPE was evaluated using the comet assay in human peripheral blood mononuclear cells (PBMC) and the acute toxicity test in mice, respectively...
June 15, 2018: Journal of Ethnopharmacology
Jessica Gill, Maja Mustapic, Ramon Diaz-Arrastia, Rael Lange, Seema Gulyani, Tom Diehl, Vida Motamedi, Nicole Osier, Robert A Stern, Dimitrios Kapogiannis
OBJECTIVE: Identify biomarkers in peripheral blood that relate to chronic post-concussive and behavioural symptoms following traumatic brain injuries (TBIs) to ultimately improve clinical management. RESEARCH DESIGN: We compared military personnel with mild TBIs (mTBIs) (n = 42) to those without TBIs (n = 22) in concentrations of tau, amyloid-beta (Aβ42) and cytokines (tumour necrosis factor alpha (TNFα, interleukin (IL)-6 and -10) in neuronal-derived exosomes from the peripheral blood...
June 18, 2018: Brain Injury: [BI]
Iñigo Galilea-Zabalza, Pilar Buil-Cosiales, Jordi Salas-Salvadó, Estefanía Toledo, Carolina Ortega-Azorín, Javier Díez-Espino, Zenaida Vázquez-Ruiz, María Dolores Zomeño, Jesús Vioque, José Alfredo Martínez, Dora Romaguera, Napoleón Perez-Farinos, José López-Miranda, Ramón Estruch, Aurora Bueno-Cavanillas, Fernando Arós, Josep Antoni Tur, Francisco Tinahones, Lluis Serra-Majem, Alba Marcos-Delgado, Manuel Ortega-Calvo, Clotilde Vázquez, Xavier Pintó, Josep Vidal, Lidia Daimiel, Miguel Delgado-Rodríguez, Pilar Matía, Dolores Corella, Andrés Diaz-López, Nancy Babio, Miguel Angel Muñoz, Montse Fitó, Sandra González-Palacios, Itziar Abete, Antonio García-Rios, Emilio Ros, Miguel Ángel Martínez-González
We assessed if a 17-item score capturing adherence to a traditional Mediterranean diet (MedDiet) was associated with better health-related quality of life among older Spanish men and women with overweight or obesity harboring the metabolic syndrome. We analyzed baseline data from 6430 men and women (age 55-70 years) participating in the PREDIMED-Plus study. PREDIMED-Plus is a multi-centre randomized trial testing an energy-restricted MedDiet combined with promotion of physical activity and behavioral therapy for primary cardiovascular prevention compared to a MedDiet alone...
2018: PloS One
Oriol Ros, Pablo José Barrecheguren, Tiziana Cotrufo, Martina Schaettin, Cristina Roselló-Busquets, Alba Vílchez-Acosta, Marc Hernaiz-Llorens, Ramón Martínez-Marmol, Fausto Ulloa, Esther T Stoeckli, Sofia J Araújo, Eduardo Soriano
Axonal growth and guidance rely on correct growth cone responses to guidance cues. Unlike the signaling cascades that link axonal growth to cytoskeletal dynamics, little is known about the crosstalk mechanisms between guidance and membrane dynamics and turnover. Recent studies indicate that whereas axonal attraction requires exocytosis, chemorepulsion relies on endocytosis. Indeed, our own studies have shown that Netrin-1/Deleted in Colorectal Cancer (DCC) signaling triggers exocytosis through the SNARE Syntaxin-1 (STX1)...
June 18, 2018: PLoS Genetics
Luis Eduardo Garrido, Juan Ramón Barrada, José Armando Aguasvivas, Agustín Martínez-Molina, Víctor B Arias, Hudson F Golino, Eva Legaz, Gloria Ferrís, Luis Rojo-Moreno
During the present decade a large body of research has employed confirmatory factor analysis (CFA) to evaluate the factor structure of the Strengths and Difficulties Questionnaire (SDQ) across multiple languages and cultures. However, because CFA can produce strongly biased estimations when the population cross-loadings differ meaningfully from zero, it may not be the most appropriate framework to model the SDQ responses. With this in mind, the current study sought to assess the factorial structure of the SDQ using the more flexible exploratory structural equation modeling approach...
June 1, 2018: Assessment
Ana M Ramos-Levi, Jacobo Rogado, Jose Miguel Sanchez-Torres, Ramón Colomer, Mónica Marazuela
BACKGROUND: Nivolumab is an anti-cancer monoclonal antibody that inhibits PD1 and modulates T-cell response. It has been shown to significantly improve survival in several types of cancer, but clinical trials have also reported an increased risk of developing immune-related adverse events (IRAEs). Endocrine IRAEs may be particularly relevant. OBJECTIVE: To comprehensively evaluate the clinical presentation of endocrine IRAEs in patients with lung cancer treated with nivolumab...
June 14, 2018: Endocrinología, Diabetes y Nutrición
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