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https://www.readbyqxmd.com/read/28324207/fructooligosaccharide-intake-promotes-epigenetic-changes-in-the-intestinal-mucosa-in-growing-and-ageing-rats
#1
Glaucia Carielo Lima, Vivian Cristine Correa Vieira, Cinthia Baú Betim Cazarin, Rafaela da Rosa Ribeiro, Stanislau Bogusz Junior, Cibele Lima de Albuquerque, Ramon Oliveira Vidal, Claudia Cardoso Netto, Áureo Tatsumi Yamada, Fabio Augusto, Mário Roberto Maróstica Junior
PURPOSE: The aim of this study was to investigate the relationship between fructooligosaccharide (FOS) intake at different life stages of Wistar rats and its stimulatory effects on intestinal parameters. METHODS: Recently weaned and ageing female rats were divided into growing and ageing treatments, which were fed diets that partially replaced sucrose with FOS for 12 weeks. RESULTS: Dietary FOS intake induced a significant increase in the numbers of Bifidobacterium and Lactobacillus in growing rats...
March 21, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28323949/plasma-arginine-asymmetric-dimethylarginine-ratio-and-incidence-of-cardiovascular-events-a-case-cohort-study
#2
Edward Yu, Miguel Ruiz-Canela, Frank B Hu, Clary B Clish, Dolores Corella, Jordi Salas-Salvadó, Adela Hruby, Montserrat Fitó, Liming Liang, Estefania Toledo, Emilio Ros, Ramón Estruch, Enrique Gómez-Gracia, Jose Lapetra, Fernando Arós, Dora Romaguera, Lluís Serra-Majem, Marta Guasch-Ferré, Dong D Wang, Miguel A Martínez-González
CONTEXT: Arginine, its methylated metabolites and other metabolites related to the urea cycle have been independently associated with cardiovascular risk, but the potential causal meaning of these associations (positive for some metabolites and negative for others) remains elusive due to a lack of studies measuring metabolite changes over time. OBJECTIVE: To examine the association between baseline and 1-year concentrations of urea cycle metabolites and cardiovascular disease in a case-cohort setting...
March 2, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28319638/actinomycetoma-an-update-on-diagnosis-and-treatment
#3
Roberto Arenas, Ramón F Fernandez Martinez, Edoardo Torres-Guerrero, Carlos Garcia
Mycetoma is a chronic infection that develops after traumatic inoculation of the skin with either true fungi or aerobic actinomycetes. The resultant infections are known as eumycetoma or actinomycetoma, respectively. Although actinomycetoma is rare in developed countries, migration of patients from endemic areas makes knowledge of this condition crucial for dermatologists worldwide. We present a review of the current concepts in the epidemiology, clinical presentation, diagnosis, and treatment of actinomycetoma...
February 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28319543/preoperative-fasting-guidelines-why-are-we-not-following-them-the-time-to-act-is-now
#4
Ramon E Abola, Tong J Gan
No abstract text is available yet for this article.
April 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28319346/determination-of-oleanolic-acid-in-human-plasma-and-its-association-with-olive-oil-intake-in-healthy-spanish-adults-within-the-epic-spain-cohort-study
#5
Genevieve Buckland, Antoni Pastor, Leila Lujan-Barroso, Carlos Alberto Gonzalez, Noemie Travier, Pilar Amiano, José María Huerta, Antonio Agudo, Carmen Navarro, María Dolores Chirlaque, Maria-José Sánchez, Miguel Rodríguez-Barranco, Aurelio Barricarte, Eva Ardanaz, Miren Dorronsoro, Amaia Molinuevo, José Ramón Quirós, Rafael de la Torre
SCOPE: Oleanolic acid (OA) is an important triterpenic compound found in olive oil, however little is known about its concentrations in human plasma. We aimed to determine plasma OA levels in a healthy Spanish population and compare them with estimates of dietary olive oil intake. METHODS AND RESULTS: The final study sample included 141 individuals randomly selected from the European Prospective Investigation into Cancer and Nutrition Spanish cohort. Dietary olive oil intake was estimated using validated dietary history questionnaires...
February 3, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28318662/mid-range-left-ventricular-ejection-fraction-clinical-profile-and-cause-of-death-in-ambulatory-patients-with-chronic-heart-failure
#6
Domingo A Pascual-Figal, Andreu Ferrero-Gregori, Ines Gomez-Otero, Rafael Vazquez, Juan Delgado-Jimenez, Jesus Alvarez-Garcia, Juan R Gimeno-Blanes, Fernando Worner-Diz, Alfredo Bardají, Luis Alonso-Pulpon, Jose Ramon Gonzalez-Juanatey, Juan Cinca
BACKGROUND: The intermediate group of patients with heart failure (HF) and mid-range left ventricular ejection fraction (HFmrEF) may constitute a specific phenotype, but a direct evidence is lacking. This study aimed to know whether this HF category is accompanied by a particular clinical phenotype and prognosis. METHODS AND RESULTS: This study includes 3446 ambulatory patients with chronic HF from two national registries. According to EF at enrollment, patients were classified as reduced (HFrEF, <40%), mid-range (HFmrEF, 40-49%) or preserved (HFpEF, ≥50%)...
March 9, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28318195/-serratia-infections-should-we-think-about-primary-immunodeficiencies
#7
Alicia Montaner Ramón, Laura Murillo Sanjuán, Cristina Martínez Faci, Carmelo Guerrero Laleona, Carmen Rodríguez-Vigil Iturrate
Chronic granulomatous disease (CGD) is a primary immunodeficiency with an incidence of 1/200,000-250,000 live births. CGD affects mainly male patients, most of the mutations being X-linked, and autosomal recessive forms occur more frequently in communities with greater numbers of consanguineous marriages. CGD is characterized by sensitivity to recurrent and severe bacterial and fungal infections, with formation of granulomas due to the inability of phagocytes to generate reactive oxygen compounds, necessary for the intracellular death of phagocytic microorganisms...
April 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28317499/a-multi-country-study-of-harms-to-children-because-of-others-drinking
#8
Anne-Marie Laslett, Georgia Rankin, Orratai Waleewong, Sarah Callinan, Hanh T M Hoang, Ramon Florenzano, Siri Hettige, Isidore Obot, Latsamy Siengsounthone, Akanidomo Ibanga, Ann Hope, Jonas Landberg, Hanh T M Vu, Thaksaphon Thamarangsi, Dag Rekve, Robin Room
OBJECTIVE: This study aims to ascertain and compare the prevalence and correlates of alcohol-related harms to children cross-nationally. METHOD: National and regional sample surveys of randomly selected households included 7,848 carers (4,223 women) from eight countries (Australia, Chile, Ireland, Lao People's Democratic Republic [PDR], Nigeria, Sri Lanka, Thailand, and Vietnam). Country response rates ranged from 35% to 99%. Face-to-face or telephone surveys asking about harm from others' drinking to children ages 0-17 years were conducted, including four specific harms: that because of others' drinking in the past year children had been (a) physically hurt, (b) verbally abused, (c) exposed to domestic violence, or (d) left unsupervised...
March 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28315267/pharmacological-modulation-of-the-sigma-1-receptor-and-the-treatment-of-pain
#9
Manuel Merlos, Javier Burgueño, Enrique Portillo-Salido, Carlos Ramón Plata-Salamán, José Miguel Vela
There is a critical need for new analgesics acting through new mechanisms of action, which could increase the efficacy with respect to existing therapies and reduce their unwanted effects. Current preclinical evidence supports the modulatory role of sigma-1 receptors (σ1R) in nociception, mainly based on the pain-attenuated phenotype of σ1R knockout mice and on the antinociceptive effect exerted by σ1R antagonists on pains of different etiologies. σ1R is highly expressed in different pain areas of the CNS and the periphery (particularly dorsal root ganglia), and interacts and modulates the functionality of different receptors and ion channels ...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28314542/impact-of-implementing-electronic-clinical-practice-guidelines-for-the-diagnosis-control-and-treatment-of-cardiovascular-risk-factors-a-pre-post-controlled-study
#10
Eva Comin, Arantxa Catalan-Ramos, Manuel Iglesias-Rodal, Maria Grau, Jose Luis Del Val, Alicia Consola, Ester Amado, Angels Pons, Manel Mata-Cases, Alicia Franzi, Ramon Ciurana, Eva Frigola, Xavier Cos, Josep Davins, Jose M Verdu-Rotellar
OBJECTIVE: To evaluate the impact of computerized clinical practice guidelines on the management, diagnosis, treatment, control, and follow-up of the main cardiovascular risk factors: hypertension, hypercholesterolaemia, and type 2 diabetes mellitus. DESIGN: Pre-post controlled study. SETTING: Catalonia, autonomous community located in north-eastern Spain. PARTICIPANTS: Individuals aged 35-74 years assigned to general practitioners of the Catalan Health Institute...
March 14, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28303472/chronic-exertional-compartment-syndrome-in-the-forearm-of-a-collegiate-softball-pitcher
#11
REVIEW
Austin Cole, John L Hiatt, Christopher Arnold, Terry Sites, Ramon Ylanon
BACKGROUND: Chronic exertional compartment syndrome (CECS) is a recognized condition in the lower limb, with many reports in the literature. However, very few instances include CECS of the upper limb. This article presents the case of a collegiate softball pitcher presenting with CECS in her right forearm. To our knowledge, this is the first case report of a softball player with CECS, with only one similar incident in a major league baseball player. PURPOSE: The rarity of this condition normally places it low on the differential diagnosis...
December 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28303324/short-qt-syndrome-in-pediatrics
#12
REVIEW
Roberta Pereira, Oscar Campuzano, Georgia Sarquella-Brugada, Sergi Cesar, Anna Iglesias, Josep Brugada, Fernando E S Cruz Filho, Ramon Brugada
Short QT syndrome is a malignant cardiac disease characterized by the presence of ventricular tachyarrhythmias leading to syncope and sudden cardiac death. Currently, international guidelines establish diagnostic criteria when QTc is below 340 ms. This entity is one of the main diseases responsible for sudden cardiac death in the pediatric population. In recent years, clinical, genetic and molecular advances in pathophysiological mechanisms related to short QT syndrome have improved diagnosis, risk stratification, and preventive measures...
March 16, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28303277/basophil-fc%C3%AE%C2%B5ri-expression-in-chronic-spontaneous-urticaria-a-poten-tial-immunological-predictor-of-response-to-omalizumab-therapy
#13
Gustavo Deza, Marta Bertolín-Colilla, Ramon M Pujol, Laia Curto-Barredo, Dulce Soto, Maribel García, Pilar Hernández, Ramon Gimeno, Ana M Giménez-Arnau
Although the efficacy of omalizumab has been clearly demonstrated in the treatment of chronic spontaneous urticaria (CSU), its mechanism of action, which results in improvement in CSU symptoms, is not entirely understood. This study investigated the effect of omalizumab on expression of the high-affinity IgE receptor (FcεRI) on blood basophils from patients with active CSU, and its association with the clinical response. Patients exhibiting significant clinical improvement showed a sharp reduction in the levels of basophil FcεRI after 4 weeks, which was maintained throughout the total duration of the treatment...
March 17, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28302465/recurrent-stemi-caused-by-multivessel-spontaneous-coronary-dissection
#14
Bruno Limpo, Juan Manuel Nogales-Asensio, María Reyes González-Fernández, Antonio Merchán-Herrera, Jose Ramón López-Mínguez
No abstract text is available yet for this article.
March 7, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28302361/unexpected-findings-after-surgery-for-suspected-appendicitis-rarely-change-treatment-in-pediatric-patients-results-from-a-cohort-study
#15
Ramon R Gorter, Paul van Amstel, Johanna H van der Lee, Patick van der Voorn, Roel Bakx, Hugo A Heij
BACKGROUND: To determine if non-operative treatment is safe in children with acute appendicitis, we evaluated the incidence of unexpected findings after an appendectomy in children, and the influence they have on subsequent treatment. METHODS: A historical cohort study (January 2004-December 2014) was performed including children, aged 0-17 years, who underwent an appendectomy for the suspicion of acute appendicitis. Patients were divided based upon histopathological examination...
March 6, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28301543/inflammation-biomarkers-in-blood-as-mortality-predictors-in-community-acquired-pneumonia-admitted-patients-importance-of-comparison-with-neutrophil-count-percentage-or-neutrophil-lymphocyte-ratio
#16
Jose Curbelo, Sergio Luquero Bueno, José María Galván-Román, Mara Ortega-Gómez, Olga Rajas, Guillermo Fernández-Jiménez, Lorena Vega-Piris, Francisco Rodríguez-Salvanes, Belén Arnalich, Ana Díaz, Ramón Costa, Hortensia de la Fuente, Ángel Lancho, Carmen Suárez, Julio Ancochea, Javier Aspa
INTRODUCTION: The increase and persistence of inflammation in community-acquired pneumonia (CAP) patients can lead to higher mortality. Biomarkers capable of measuring this inadequate inflammatory response are likely candidates to be related with a bad outcome. We investigated the association between concentrations of several inflammatory markers and mortality of CAP patients. MATERIAL AND METHODS: This was a prospective study of hospitalised CAP patients in a Spanish university hospital...
2017: PloS One
https://www.readbyqxmd.com/read/28300467/association-of-cyp1a1-and-cyp1b1-polymorphisms-with-bone-mineral-density-variations-in-postmenopausal-mexican-mestizo-women
#17
Bertha Chávez, Felipe Vilchis, David Rojano-Mejía, Ramón Mauricio Coral Vázquez, María Del Carmen Aguirre-García, Patricia Canto
Herein, we investigated potential associations between polymorphisms of genes related to estrogen metabolism and bone mineral density (BMD) in postmenopausal women. This was a cross-sectional study, in which two hundred and ninety postmenopausal Mexican-Mestizo women were studied. The BMD of the lumbar spine (LS), total hip (TH), and femoral neck (FN) was measured. The distribution of the genetic polymorphisms, including rs1799814 and rs1048943 at CYP1A1 as well as rs1056836 at CYP1B1, were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), single-stranded conformational polymorphism (SSCP), and DNA sequencing...
March 16, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28300250/a-new-class-of-silica-supported-chromo-fluorogenic-chemosensors-for-anion-recognition-based-on-a-selenourea-scaffold
#18
Arianna Casula, Antoni Llopis-Lorente, Alessandra Garau, Francesco Isaia, Maciej Kubicki, Vito Lippolis, Félix Sancenón, Ramón Martínez-Máñez, Agata Owczarzak, Claudio Santi, M Andrea Scorciapino, Claudia Caltagirone
The first example of a chemosensor (L) containing a selenourea moiety is described here. L is able to colorimetrically sense the presence of CN(-) and S(2-) in H2O : MeCN (75 : 25, v/v). Moreover, when L is loaded into functionalised mesoporous silica nanoparticles an increase in the selectivity towards S(2-) occurs via a selective fluorescence response.
March 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28300223/role-of-cyclooxygenase-2-on-intermittent-hypoxia-induced-lung-tumor-malignancy-in-a-mouse-model-of-sleep-apnea
#19
Noelia Campillo, Marta Torres, Antoni Vilaseca, Paula Naomi Nonaka, David Gozal, Jordi Roca-Ferrer, César Picado, Josep Maria Montserrat, Ramon Farré, Daniel Navajas, Isaac Almendros
An adverse role for obstructive sleep apnea (OSA) in cancer epidemiology and outcomes has recently emerged from clinical and animal studies. In animals, intermittent hypoxia (IH) mimicking OSA promotes tumor malignancy both directly and via host immune alterations. We hypothesized that IH could potentiate cancer aggressiveness through activation of the cyclooxygenase-2 (COX-2) pathway and the concomitant increases in prostaglandin E2 (PGE2). The contribution of the COX-2 in IH-induced enhanced tumor malignancy was assessed using celecoxib as a COX-2 specific inhibitor in a murine model of OSA bearing Lewis lung carcinoma (LLC1) tumors...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28298524/novel-noncatalytic-substrate-selective-p38%C3%AE-specific-mapk-inhibitors-with-endothelial-stabilizing-and-anti-inflammatory-activity
#20
Nirav G Shah, Mohan E Tulapurkar, Aparna Ramarathnam, Amanda Brophy, Ramon Martinez, Kellie Hom, Theresa Hodges, Ramin Samadani, Ishwar S Singh, Alexander D MacKerell, Paul Shapiro, Jeffrey D Hasday
The p38 MAPK family is composed of four kinases of which p38α/MAPK14 is the major proinflammatory member. These kinases contribute to many inflammatory diseases, but the currently available p38 catalytic inhibitors (e.g., SB203580) are poorly effective and cause toxicity. We reasoned that the failure of catalytic p38 inhibitors may derive from their activity against noninflammatory p38 isoforms (e.g., p38β/MAPK11) and loss of all p38α-dependent responses, including anti-inflammatory, counterregulatory responses via mitogen- and stress-activated kinase (MSK) 1/2 and Smad3...
March 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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