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https://www.readbyqxmd.com/read/29677474/unraveling-the-complex-interplay-between-t-cell-metabolism-and-function
#1
Ramon I Klein Geltink, Ryan L Kyle, Erika L Pearce
Metabolism drives function, on both an organismal and a cellular level. In T cell biology, metabolic remodeling is intrinsically linked to cellular development, activation, function, differentiation, and survival. After naive T cells are activated, increased demands for metabolic currency in the form of ATP, as well as biomass for cell growth, proliferation, and the production of effector molecules, are met by rewiring cellular metabolism. Consequently, pharmacological strategies are being developed to perturb or enhance selective metabolic processes that are skewed in immune-related pathologies...
April 26, 2018: Annual Review of Immunology
https://www.readbyqxmd.com/read/29677153/entomofauna-associated-with-agroforestry-systems-of-timber-species-and-cacao-in-the-southern-region-of-the-maracaibo-lake-basin-m%C3%A3-rida-venezuela
#2
Marina Mazón, Daniel Sánchez-Angarita, Francisco A Díaz, Néstor Gutiérrez, Ramón Jaimez
Agroforestry systems are environment-friendly production systems which help to preserve biodiversity while providing people with a way of earning a living. Cacao is a historically important crop in Venezuela that traditionally has been produced in agroforestry systems. However, few studies have evaluated how different trees used in those systems affect the dynamics and abundance of insects. The present study evaluated the entomofauna assemblages associated with different combinations of four timber-yielding trees and four Criollo cacao cultivars established in a lowland tropical ecosystem in Venezuela...
April 20, 2018: Insects
https://www.readbyqxmd.com/read/29676281/risk-thresholds-for-alcohol-consumption-combined-analysis-of-individual-participant-data-for-599-912-current-drinkers-in-83-prospective-studies
#3
Angela M Wood, Stephen Kaptoge, Adam S Butterworth, Peter Willeit, Samantha Warnakula, Thomas Bolton, Ellie Paige, Dirk S Paul, Michael Sweeting, Stephen Burgess, Steven Bell, William Astle, David Stevens, Albert Koulman, Randi M Selmer, W M Monique Verschuren, Shinichi Sato, Inger Njølstad, Mark Woodward, Veikko Salomaa, Børge G Nordestgaard, Bu B Yeap, Astrid Fletcher, Olle Melander, Lewis H Kuller, Beverley Balkau, Michael Marmot, Wolfgang Koenig, Edoardo Casiglia, Cyrus Cooper, Volker Arndt, Oscar H Franco, Patrik Wennberg, John Gallacher, Agustín Gómez de la Cámara, Henry Völzke, Christina C Dahm, Caroline E Dale, Manuela M Bergmann, Carlos J Crespo, Yvonne T van der Schouw, Rudolf Kaaks, Leon A Simons, Pagona Lagiou, Josje D Schoufour, Jolanda M A Boer, Timothy J Key, Beatriz Rodriguez, Conchi Moreno-Iribas, Karina W Davidson, James O Taylor, Carlotta Sacerdote, Robert B Wallace, J Ramon Quiros, Rosario Tumino, Dan G Blazer, Allan Linneberg, Makoto Daimon, Salvatore Panico, Barbara Howard, Guri Skeie, Timo Strandberg, Elisabete Weiderpass, Paul J Nietert, Bruce M Psaty, Daan Kromhout, Elena Salamanca-Fernandez, Stefan Kiechl, Harlan M Krumholz, Sara Grioni, Domenico Palli, José M Huerta, Jackie Price, Johan Sundström, Larraitz Arriola, Hisatomi Arima, Ruth C Travis, Demosthenes B Panagiotakos, Anna Karakatsani, Antonia Trichopoulou, Tilman Kühn, Diederick E Grobbee, Elizabeth Barrett-Connor, Natasja van Schoor, Heiner Boeing, Kim Overvad, Jussi Kauhanen, Nick Wareham, Claudia Langenberg, Nita Forouhi, Maria Wennberg, Jean-Pierre Després, Mary Cushman, Jackie A Cooper, Carlos J Rodriguez, Masaru Sakurai, Jonathan E Shaw, Matthew Knuiman, Trudy Voortman, Christa Meisinger, Anne Tjønneland, Hermann Brenner, Luigi Palmieri, Jean Dallongeville, Eric J Brunner, Gerd Assmann, Maurizio Trevisan, Richard F Gillum, Ian Ford, Naveed Sattar, Mariana Lazo, Simon G Thompson, Pietro Ferrari, David A Leon, George Davey Smith, Richard Peto, Rod Jackson, Emily Banks, Emanuele Di Angelantonio, John Danesh
BACKGROUND: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. METHODS: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, and the UK Biobank)...
April 14, 2018: Lancet
https://www.readbyqxmd.com/read/29676004/rapidly-changing-myeloma-epidemiology-in-the-general-population-increased-incidence-older-patients-and-longer-survival
#4
REVIEW
Ingemar Turesson, Magnus Bjorkholm, Cecilie Hveding Blimark, Sigurdur Kristinsson, Ramon Velez, Ola Landgren
The incidence of multiple myeloma is characterized by a steep increase with advancing age. Dramatic improvements in survival have been reported in clinical trials; however, elderly patients are generally underrepresented in these. The aims of this study are to review patterns of incidence and survival in multiple myeloma in the general population. We searched PubMed for population-based studies on trends in incidence and survival published between January 1, 2000 and June 30, 2017 and based on regional or national cancer registries and report the following results of the review...
April 20, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29675615/a-modular-approach-for-high-flux-lactic-acid-production-from-methane-in-an-industrial-medium-using-engineered-methylomicrobium-buryatense-5gb1
#5
Shivani Garg, James M Clomburg, Ramon Gonzalez
Convergence of market drivers such as abundant availability of inexpensive natural gas and increasing awareness of its global warming effects have created new opportunities for the development of small-scale gas-to-liquid (GTL) conversion technologies that can efficiently utilize methane, the primary component of natural gas. Leveraging the unique ability of methanotrophs that use methane as carbon and energy source, biological GTL platforms can be envisioned that are readily deployable at remote petroleum drilling sites where large chemical GTL infrastructure is uneconomical to set-up...
April 19, 2018: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29675133/benefit-of-oleuropein-aglycone-for-alzheimer-s-disease-by-promoting-autophagy
#6
REVIEW
Joaquín G Cordero, Ramón García-Escudero, Jesús Avila, Ricardo Gargini, Vega García-Escudero
Alzheimer's disease is a proteinopathy characterized by accumulation of hyperphosphorylated Tau and β -amyloid. Autophagy is a physiological process by which aggregated proteins and damaged organelles are eliminated through lysosomal digestion. Autophagy deficiency has been demonstrated in Alzheimer's patients impairing effective elimination of aggregates and damaged mitochondria, leading to their accumulation, increasing their toxicity and oxidative stress. In the present study, we demonstrated by microarray analysis the downregulation of fundamental autophagy and mitophagy pathways in Alzheimer's patients...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29675051/seasonal-effect-on-the-biological-activities-of-litsea-glaucescens-kunth-extracts
#7
Julio César López-Romero, Humberto González-Ríos, Aida Peña-Ramos, Carlos Velazquez, Moises Navarro, Ramón Robles-Zepeda, Evelin Martínez-Benavidez, Inocencio Higuera-Ciapara, Claudia Virués, José Luis Olivares, Zaira Domínguez, Javier Hernández
This study shows the seasonal effect on the antioxidant, antiproliferative, and antimicrobial activities of L. glaucescens Kunth (LG) leaves extracts. Their antioxidant activity was evaluated through the DPPH, FRAP, and ORAC assays. Their phenolic content (PC) was determined by means of the Folin-Ciocalteu method, and the main phenolic compounds were identified through a HPLC-DAD analysis. Antiproliferative activity was determined by MTT assay against HeLa, LS 180, M12.C3.F6, and ARPE cell lines. Antimicrobial potential was evaluated against Staphylococcus aureus and Escherichia coli using a microdilution method...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29674994/a-cross-sectional-study-on-cerebral-hemodynamics-after-mild-traumatic-brain-injury-in-a-pediatric-population
#8
Corey M Thibeault, Samuel Thorpe, Michael J O'Brien, Nicolas Canac, Mina Ranjbaran, Ilyas Patanam, Artin Sarraf, James LeVangie, Fabien Scalzo, Seth J Wilk, Ramon Diaz-Arrastia, Robert B Hamilton
The microvasculature is prominently affected by traumatic brain injury (TBI), including mild TBI (concussion). Assessment of cerebral hemodynamics shows promise as biomarkers of TBI, and may help inform development of therapies aimed at promoting neurologic recovery. The objective of this study was to assess the evolution in cerebral hemodynamics observable with transcranial Doppler (TCD) ultrasound in subjects suffering from a concussion at different intervals during recovery. Pediatric subjects between the ages of 14 and 19 years clinically diagnosed with a concussion were observed at different points post-injury...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29673899/it-s-about-time-cesarean-sections-and-neonatal-health
#9
Ana María Costa-Ramón, Ana Rodríguez-González, Miquel Serra-Burriel, Carlos Campillo-Artero
Cesarean sections have been associated in the literature with poorer newborn health, particularly with a higher incidence of respiratory morbidity. Most studies suffer, however, from potential omitted variable bias, as they are based on simple comparisons of mothers who give birth vaginally and those who give birth by cesarean section. We try to overcome this limitation and provide credible causal evidence by using variation in the probability of having a c-section that is arguably unrelated to maternal and fetal characteristics: variation by time of day...
March 27, 2018: Journal of Health Economics
https://www.readbyqxmd.com/read/29673731/duplication-of-sox9-associated-with-46-xx-ovotesticular-disorder-of-sex-development
#10
Berenice López-Hernández, Juan Pablo Méndez, Ramón Mauricio Coral-Vázquez, Jesús Benítez-Granados, Juan Carlos Zenteno, Vanessa Villegas-Ruiz, Raúl Calzada-León, Daniela Soderlund, Patricia Canto
RESEARCH QUESTION: The purpose of the present study was to investigate whether ten unrelated SRY-negative individuals with this sex differentiation disorder presented a double dose of SOX9 as the cause of their disease. DESIGN: Ten unrelated SRY-negative 46,XX ovotesticular disorder of sexual development (DSD) subjects were molecularly studied. Multiplex-ligation dependent probe amplification (MLPA) and quantitative real-time PCR analysis (qRT-PCR) for SOX9 were performed...
April 4, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29673623/detection-of-serum-antibodies-in-children-and-adolescents-against-balamuthia-mandrillaris-naegleria-fowleri-and-acanthamoeba-t4
#11
Luis Fernando Lares-Jiménez, Manuel Alejandro Borquez-Román, Rosalía Alfaro-Sifuentes, María Mercedes Meza-Montenegro, Ramón Casillas-Hernández, Fernando Lares-Villa
The presence of free-living amoebae of the genera Naegleria, Acanthamoeba and Balamuthia, which contain pathogenic species for humans and animals, has been demonstrated several times and in different natural aquatic environments in the northwest of Mexico. With the aim of continuing the addition of knowledge about immunology of pathogenic free-living amoebae, 118 sera from children and adolescents, living in three villages, were studied. Humoral IgG response against B. mandrillaris, N. fowleri and Acanthamoeba sp...
April 16, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29672979/interaction-of-ascaridole-carvacrol-and-caryophyllene-oxide-from-essential-oil-of-chenopodium-ambrosioides-l-with-mitochondria-in-leishmania-and-other-eukaryotes
#12
Lianet Monzote, Gerald Geroldinger, Matthias Tonner, Ramón Scull, Sritama De Sarkar, Sophie Bergmann, Markus Bacher, Katrin Staniek, Mitali Chatterjee, Thomas Rosenau, Lars Gille
The antileishmanial activity of the essential oil (EO) from Chenopodium ambrosioides L. has been demonstrated in vitro and in animal models, attributed to the major components of the EO. This study focused on the effects of the three major EO compounds carvacrol, caryophyllene oxide (Caryo), and the antileishmanial endoperoxide ascaridole (Asc) on mitochondrial functions in Leishmania tarentolae promastigotes (LtP). EO and Caryo were able to partially inhibit the leishmanial electron transport chain, whereas other components failed to demonstrate a direct immediate effect...
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29672741/multimodal-brain-changes-in-first-episode-mania-a-voxel-based-morphometry-functional-magnetic-resonance-imaging-and-connectivity-study
#13
José M Goikolea, Danai Dima, Ramón Landín-Romero, Imma Torres, Giuseppe DelVecchio, Marc Valentí, Benedikt L Amann, Caterina Mar Bonnín, Peter J McKenna, Edith Pomarol-Clotet, Sophia Frangou, Eduard Vieta
Background: Brain structural and functional changes in bipolar disorder (BD) are well-established findings, but it is uncertain whether these changes are already present in first episode mania (FEM). Methods: We compared 31 FEM subjects, with 31 healthy individuals matched for age, sex, and premorbid IQ. Whole-brain voxel-wise morphometry, functional magnetic resonance imaging during the n-back task, and a functional connectivity analysis were performed. Results: There were no volumetric differences between the 2 groups...
April 17, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29672632/correction-biometrics-accessibility-challenge-or-opportunity
#14
Ramon Blanco-Gonzalo, Chiara Lunerti, Raul Sanchez-Reillo, Richard Guest
[This corrects the article DOI: 10.1371/journal.pone.0194111.].
2018: PloS One
https://www.readbyqxmd.com/read/29672227/mimicking-a-flow-limited-human-upper-airway-using-a-collapsible-tube-relationships-between-flow-patterns-and-pressures-in-a-respiratory-model
#15
Kaixian Zhu, Ramon Farre, Ira Katz, Sébastien Hardy, Pierre Escourrou
The upper airway (UA) in humans is commonly modeled as a Starling resistor. However, negative effort dependence (NED) observed in some patients with obstructive sleep apnea (OSA) contradicts predictions based on the Starling resistor model in which inspiratory flow is independent of inspiratory driving pressure when flow is limited. In a respiratory bench model consisting of a collapsible tube and an active lung model (ASL5000), inspiratory flow characteristics were investigated in relation to upstream, downstream and extra-luminal pressures (denoted as Pus, Pds and Pout, respectively) by varying inspiratory effort (muscle pressure) from -1 to -20 cmH2 O in the active lung...
April 19, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29672210/prognostic-utility-of-stress-testing-and-cardiac-biomarkers-in-menopausal-women-at-low-to-intermediate-risk-for-coronary-artery-disease-smart-study-5-year-outcome
#16
Sahar S Abdelmoneim, Caroline A Ball, Francesca Mantovani, Mary E Hagen, Susan Eifert-Rain, Susan Wilansky, Ramon Castello, Patricia A Pellikka, Patricia J M Best, Sharon L Mulvagh
BACKGROUND: In women with low to intermediate risk of coronary artery disease (CAD), prognostic detection strategies have been controversial. We present the follow-up data of the SMART trial in peri/postmenopausal women at low to intermediate risk of CAD. OBJECTIVES: To determine the value of contrast stress echocardiography (CSE), stress electrocardiogram (sECG), and serum biomarkers for prediction of cardiovascular events (CE) in peri/postmenopausal women at low to intermediate risk of CAD...
April 19, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29671794/phytochemical-study-of-the-ecuadorian-species-lepechinia-mutica-benth-epling-and-high-antifungal-activity-of-carnosol-against-pyricularia-oryzae
#17
Jorge Ramírez, Gianluca Gilardoni, Erika Ramón, Solveig Tosi, Anna Maria Picco, Carlo Bicchi, Giovanni Vidari
The plant Lepechinia mutica (Benth.) Epling (family Lamiaceae) is endemic to Ecuador. In the present study, we report some major non-volatile secondary metabolites from the leaves and the chemistry of the essential oil distilled from the flowers. The main identified compounds were carnosol, viridiflorol, ursolic acid, oleanolic acid, chrysothol, and 5-hydroxy-4′,7-dimethoxy flavone. Their structures were determined by X-ray diffraction and NMR and MS techniques. The essential oil showed a chemical composition similar to that distilled from the leaves, but with some qualitative and quantitative differences regarding several minor compounds...
April 19, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29670776/-kit-d816v-positive-acute-mast-cell-leukemia-associated-with-normal-karyotype-acute-myeloid-leukemia
#18
Marta Lopes, Maria Dos Anjos Teixeira, Cláudia Casais, Vanessa Mesquita, Patrícia Seabra, Renata Cabral, José Palla-García, Catarina Lau, João Rodrigues, Maria Jara-Acevedo, Inês Freitas, Jose Ramón Vizcaíno, Jorge Coutinho, Luis Escribano, Alberto Orfao, Margarida Lima
Introduction: Mast cell (MC) leukemia (MCL) is extremely rare. We present a case of MCL diagnosed concomitantly with acute myeloblastic leukemia (AML). Case Report: A 41-year-old woman presented with asthenia, anorexia, fever, epigastralgia, and diarrhea. She had a maculopapular skin rash, hepatosplenomegaly, retroperitoneal adenopathies, pancytopenia, 6% blast cells (BC) and 20% MC in the peripheral blood, elevated lactate dehydrogenase, cholestasis, hypoalbuminemia, hypogammaglobulinemia, and increased serum tryptase (184  μ g/L)...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29668728/correction-the-role-of-cgmp-as-a-mediator-of-lipolysis-in-bovine-oocytes-and-its-effects-on-embryo-development-and-cryopreservation
#19
Kátia R L Schwarz, Fernanda C de Castro, Letícia Schefer, Ramon C Botigelli, Daniela M Paschoal, Hugo Fernandes, Cláudia L V Leal
[This corrects the article DOI: 10.1371/journal.pone.0191023.].
2018: PloS One
https://www.readbyqxmd.com/read/29668113/molecular-dynamics-analysis-of-charge-transport-in-ionic-liquid-electrolytes-containing-added-salt-with-mono-di-and-trivalent-metal-cations
#20
José Manuel Vicent-Luna, Eneko Azaceta, Said Hamad, José Manuel Ortiz-Roldán, Ramón Tena-Zaera, Sofía Calero, Juan Antonio Anta
Among many other applications, room-temperature ionic liquids (ILs) are used as electrolytes for storage and energy-conversion devices. In this work, we investigate, at the microscopic level, the structural and dynamical properties of 1-methyl-1-butyl-pyrrolidinium bis(trifluoromethanesulfonyl) imide [C4 PYR]+ [Tf2 N]- IL-based electrolytes for metal-ion batteries. We carried out molecular dynamics simulations of electrolytes mainly composed of [C4 PYR]+ [Tf2 N]- IL with the addition of Mn+ -[Tf2 N]- metal salts (M=Li+ , Na+ , Ni2+ , Zn2+ , Co2+ , Cd2+ , and Al3+ , n=1, 2, and 3) dissolved in the IL...
April 18, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
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