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https://www.readbyqxmd.com/read/28094393/correction-copper-ii-catalyzed-synthesis-of-novel-helical-luminescent-benzo-4-5-imidazo-1-2-a-1-10-phenanthrolines-via-an-intramolecular-c-h-amination-reaction
#1
Ramon Borges da Silva, Rodolfo Inêz Teixeira, James L Wardell, Solange M S V Wardell, Simon J Garden
Correction for 'Copper(ii) catalyzed synthesis of novel helical luminescent benzo[4,5]imidazo[1,2-a][1,10]phenanthrolines via an intramolecular C-H amination reaction' by Ramon Borges da Silva, et al., Org. Biomol. Chem., 2017, DOI: 10.1039/c6ob02508k.
January 17, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28093597/telangiectatic-mycosis-fungoides-a-new-clinicopathological-presentation-mimicking-acquired-naevoid-telangiectasia
#2
Lidia García-Colmenero, Laia Curto-Barredo, Ignacio Gómez-Martin, Fernando Gallardo, Ramon M Pujol
is missing (Short communication).
January 17, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28093202/sensorless-h%C3%A2-speed-tracking-synthesis-for-surface-mount-permanent-magnet-synchronous-motor
#3
Ramón Ramírez-Villalobos, Luis T Aguilar, Luis N Coria
In this paper, a sensorless speed tracking control is proposed for a surface-mount permanent magnet synchronous motor by using a nonlinear H∞-controller via stator currents measurements for feedback. An output feedback nonlinear H∞-controller was designed such that the undisturbed system is uniformly asymptotically stable around the desired speed reference, while also the effects of external vanishing and non-vanishing disturbances, noise, and input backlash were attenuated locally. The rotor position was calculated from the causal dynamic output feedback compensator and from the desired speed reference...
January 13, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28091591/intraarterial-route-increases-the-risk-of-cerebral-lesions-after-mesenchymal-cell-administration-in-animal-model-of-ischemia
#4
Bárbara Argibay, Jesse Trekker, Uwe Himmelreich, Andrés Beiras, Antonio Topete, Pablo Taboada, María Pérez-Mato, Alba Vieites-Prado, Ramón Iglesias-Rey, José Rivas, Anna M Planas, Tomás Sobrino, José Castillo, Francisco Campos
Mesenchymal stem cells (MSCs) are a promising clinical therapy for ischemic stroke. However, critical parameters, such as the most effective administration route, remain unclear. Intravenous (i.v.) and intraarterial (i.a.) delivery routes have yielded varied outcomes across studies, potentially due to the unknown MSCs distribution. We investigated whether MSCs reached the brain following i.a. or i.v. administration after transient cerebral ischemia in rats, and evaluated the therapeutic effects of both routes...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28091528/super-emitters-in-natural-gas-infrastructure-are-caused-by-abnormal-process-conditions
#5
Daniel Zavala-Araiza, Ramón A Alvarez, David R Lyon, David T Allen, Anthony J Marchese, Daniel J Zimmerle, Steven P Hamburg
Effectively mitigating methane emissions from the natural gas supply chain requires addressing the disproportionate influence of high-emitting sources. Here we use a Monte Carlo simulation to aggregate methane emissions from all components on natural gas production sites in the Barnett Shale production region (Texas). Our total emission estimates are two-thirds of those derived from independent site-based measurements. Although some high-emitting operations occur by design (condensate flashing and liquid unloadings), they occur more than an order of magnitude less frequently than required to explain the reported frequency at which high site-based emissions are observed...
January 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28089777/bioresorbable-vascular-scaffold-to-treat-malignant-in-stent-restenosis-in-a-patient-with-nickel-allergy
#6
Alfonso Jurado-Román, María T López-Lluva, Ignacio Sánchez-Pérez, Jesús Piqueras-Flores, Ramón Maseda, Fernando Lozano-Ruíz-Poveda
Nickel is the most frequent allergen in patients with allergic contact dermatitis and nickel allergy has been associated with recurrent in-stent restenosis. However, it is often misdiagnosed because of a low suspicion threshold. It should be discarded in patients with recurrent in-stent restenosis, especially if their medical history reveals prior contact dermatitis. It is also noteworthy and rarely specified that even newer generation stents that use novel metal alloys also contain low amounts of nickel. To avoid the implantation of new stents containing this metal, when percutaneous coronary intervention is indicated, drug eluting balloons or bioresorbable vascular scaffolds associated with small doses of steroids could provide good alternatives of treatment...
January 2, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28089328/usefulness-of-three-dimensional-transthoracic-echocardiograhy-in-the-localization-of-the-micra-leadless-pacemaker
#7
José Luis Martínez-Sande, Carlos Peña-Gil, Javier García-Seara, Moisés Rodríguez-Mañero, María Amparo Martínez-Monzonis, José Ramón González-Juanatey
No abstract text is available yet for this article.
January 11, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28088804/monitoring-noninvasive-ventilation-in-patients-with-obesity-hypoventilation-syndrome-comparison-between-ventilator-built-in-software-and-respiratory-polygraphy
#8
Ramon Fernandez Alvarez, Claudio Rabec, Gemma Rubinos Cuadrado, Juan Alejandro Cascon Hernandez, Patricia Rodriguez, Marjolaine Georges, Pere Casan
BACKGROUND: Polygraphy (PG) remains the standard method of assessing noninvasive ventilation (NIV) effectiveness. Built-in software (BIS) of recent NIV equipment provides estimates of some ventilator parameters, but their usefulness is unclear. OBJECTIVES: To assess the reliability of BIS compared with PG in a cohort of obesity hypoventilation syndrome (OHS) patients on NIV. METHODS: Thirty stable OHS patients on NIV were evaluated in an outpatient setting with simultaneous PG and BIS recordings...
January 14, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28088138/fast-simulation-of-brownian-dynamics-in-a-crowded-environment
#9
Stephen Smith, Ramon Grima
Brownian dynamics simulations are an increasingly popular tool for understanding spatially extended biochemical reaction systems. Recent improvements in our understanding of the cellular environment show that volume exclusion effects are fundamental to reaction networks inside cells. These systems are frequently studied by incorporating inert hard spheres (crowders) into three-dimensional Brownian dynamics (BD) simulations; however these methods are extremely slow owing to the sheer number of possible collisions between particles...
January 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28088073/strategies-to-design-clinical-studies-to-identify-predictive-biomarkers-in-cancer-research
#10
REVIEW
Jose Luis Perez-Gracia, Miguel F Sanmamed, Ana Bosch, Ana Patiño-Garcia, Kurt A Schalper, Victor Segura, Joaquim Bellmunt, Josep Tabernero, Christopher J Sweeney, Toni K Choueiri, Miguel Martín, Juan Pablo Fusco, Maria Esperanza Rodriguez-Ruiz, Alfonso Calvo, Celia Prior, Luis Paz-Ares, Ruben Pio, Enrique Gonzalez-Billalabeitia, Alvaro Gonzalez Hernandez, David Páez, Jose María Piulats, Alfonso Gurpide, Mapi Andueza, Guillermo de Velasco, Roberto Pazo, Enrique Grande, Pilar Nicolas, Francisco Abad-Santos, Jesus Garcia-Donas, Daniel Castellano, María J Pajares, Cristina Suarez, Ramon Colomer, Luis M Montuenga, Ignacio Melero
The discovery of reliable biomarkers to predict efficacy and toxicity of anticancer drugs remains one of the key challenges in cancer research. Despite its relevance, no efficient study designs to identify promising candidate biomarkers have been established. This has led to the proliferation of a myriad of exploratory studies using dissimilar strategies, most of which fail to identify any promising targets and are seldom validated. The lack of a proper methodology also determines that many anti-cancer drugs are developed below their potential, due to failure to identify predictive biomarkers...
December 30, 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28087030/dermoscopic-characteristics-of-a-cutaneous-histiocytic-sarcoma-in-a-young-patient
#11
Ines Escandell, Maria Dolores Ramon, Sara Sánchez, Liria Terradez, Esperanza Jorda
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28079954/conformational-sers-classification-of-k-ras-point-mutations-for-cancer-diagnostics
#12
Judit Morla-Folch, Patricia Gisbert-Quilis, Matteo Masetti, Eduardo Garcia-Rico, Ramon A Alvarez-Puebla, Luca Guerrini
Point mutations in Ras oncogenes are routinely screened for diagnostics and treatment of tumors (especially in colorectal cancer). Here, we develop an optical approach based on direct SERS coupled with chemometrics for the study of the specific conformations that single-point mutations impose on a relatively large fragment of the K-Ras gene (141 nucleobases). Results obtained offer the unambiguous classification of different mutations providing a potentially useful insight for diagnostics and treatment of cancer in a sensitive, fast, direct and inexpensive manner...
January 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28079007/novel-therapies-targeting-cardioprotection-and-regeneration
#13
Valeria Garrido, Evelyn Mendoza-Torres, Jaime A Riquelme, Ariel Díaz, Marcela Pizarro, Mario Bustamante, Myra N Chavez, María Paz Ocaranza, Rosemarie Mellado, Ramon Corbalan, Miguel L Allende, Sergio Lavandero
Cardiovascular disease is the leading cause of death worldwide. The heart is susceptible to pathologies that impact the myocardium directly, such myocardial infarction and consequent heart failure, as well as conditions with indirect cardiac effects, such cancer treatment-related cardiotoxicity. As the contractile cells of the heart, cardiomyocytes are essential for normal cardiac function. Various stress stimuli may result in transient damage or cell death in cardiomyocytes through apoptosis, necrosis or maladaptive autophagy...
January 12, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28078804/a-low-protein-diet-induces-body-weight-loss-and-browning-of-subcutaneous-white-adipose-tissue-through-enhanced-expression-of-hepatic-fibroblast-growth-factor-21-fgf21
#14
Albert Pérez-Martí, Maite Garcia-Guasch, Anna Tresserra-Rimbau, Alexandra Carrilho-Do-Rosário, Ramon Estruch, Jordi Salas-Salvadó, Miguel Ángel Martínez-González, Rosa Lamuela-Raventós, Pedro F Marrero, Diego Haro, Joana Relat
SCOPE: Fibroblast growth factor 21 (FGF21) is considered a promising therapeutic candidate for the treatment of obesity. Since FGF21 production is regulated by various nutritional factors, we analyze the impact of low protein intake on circulating levels of this growth hormone in mice and in a sub cohort of the PREDIMED (Prevención con Dieta Mediterránea) trial. We also describe the role of hepatic FGF21 in metabolic adaptation to a low-protein diet (LPD). METHODS AND RESULTS: We fed control and liver-specific Fgf21 knockout (LFgf21KO) mice a LPD...
January 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28077761/on-the-autorotation-of-animal-wings
#15
Victor Manuel Ortega-Jimenez, Antonio Martín-Alcántara, Ramon Fernandez-Feria, Robert Dudley
Botanical samaras spin about their centre of mass and create vertical aerodynamic forces which slow their rate of descent. Descending autorotation of animal wings, however, has never been documented. We report here that isolated wings from Anna's hummingbirds, and also from 10 species of insects, can stably autorotate and achieve descent speeds and aerodynamic performance comparable to those of samaras. A hummingbird wing loaded at its base with the equivalent of 50% of the bird's body mass descended only twice as fast as an unloaded wing, and rotated at frequencies similar to those of the wings in flapping flight...
January 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28076297/dynamics-of-the-cardiovascular-autonomic-regulation-during-orthostatic-challenge-is-more-relaxed-in-women
#16
Sina Reulecke, Sonia Charleston-Villalobos, Andreas Voss, Ramón González-Camarena, Jesús González-Hermosillo, Mercedes Gaitán-González, Guadalupe Hernández-Pacheco, Rico Schroeder, Tomás Aljama-Corrales
Linear dynamic analysis of cardiovascular and respiratory time series was performed in healthy subjects with respect to gender by shifted short-term segments throughout a head-up tilt (HUT) test. Beat-to-beat intervals (BBI), systolic (SYS) and diastolic (DIA) blood pressure and respiratory interval (RESP) time series were acquired in 14 men and 15 women. In time domain (TD), the descending slope of the auto-correlation function (ACF) (BBI_a31cor) was more pronounced in women than in men (p<0.05) during the HUT test and considerably steeper (p<0...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28075490/soluble-transferrin-receptor-and-risk-of-type-2-diabetes-in-the-obese-and-non-obese
#17
Jose C Fernández-Cao, Victoria Arija, Núria Aranda, Josep Basora, Javier Diez-Espino, Ramón Estruch, Montse Fitó, Dolores Corella D Pharm, Jordi Salas-Salvadó
BACKGROUND: Studies evaluating the relationship between soluble transferrin receptor (sTfR), a biomarker inversely related to body iron stores, and risk of type 2 diabetes mellitus (T2DM) are scarce and inconclusive. Furthermore, sTfR concentrations have been observed to be significantly higher in obese than in non-obese individuals. Therefore, the aim of the present study was to assess the relationship between sTfR and the risk of T2DM in obese and non-obese subjects. DESIGN: A nested case-control study of 153 cases of newly diagnosed diabetic subjects, 73 obese and 80 non-obese, and 306 individually matched-controls, 138 obese and 166 non-obese, who did not develop T2DM for a median 6-year follow-up (interquartile range: 3...
January 11, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28075191/reduction-mammaplasty-improves-levels-of-anxiety-depression-and-body-image-satisfaction-in-patients-with-symptomatic-macromastia-in-the-short-and-long-term
#18
Esther Pérez-Panzano, Ana Gascón-Catalán, Ramón Sousa-Domínguez, Patricia Carrera-Lasfuentes, Javier García-Campayo, Antonio Güemes-Sánchez
OBJECTIVE: To evaluate the psychological consequences (anxiety, depression and body image dissatisfaction) of symptomatic macromastia and the effectiveness of breast reduction surgery in re-establishing the mental health of the patient in the short and long term. METHOD: 119 patients over 18 years old who had been diagnosed with symptomatic macromastia were assessed, before surgery, one month after the operation and one year later. Patients completed the Hospital Anxiety and Depression Scale (HADS) and the Body Image Dissatisfaction subscale of the Eating Disorders Inventory (EDI-2)...
January 11, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28073980/presence-and-prevalence-of-raffaelea-lauricola-cause-of-laurel-wilt-in-different-species-of-ambrosia-beetle-in-florida-usa
#19
Randy C Ploetz, Joshua L Konkol, Teresa Narvaez, Rita E Duncan, Ramon J Saucedo, Alina Campbell, Julio Mantilla, Daniel Carrillo, Paul E Kendra
We summarize the information available on ambrosia beetle species that have been associated in Florida with Raffaelea lauricola T.C. Harr., Fraedrich & Aghayeva, the primary symbiont of Xyleborus glabratus Eichhoff and cause of laurel wilt. In total, 14 species in Ambrosiodmus, Euwallacea, Premnobius, Xyleborus, Xyleborinus, and Xylosandrus were either reared from laurel wilt-affected host trees or trapped in laurel wilt-affected stands of the same, and assayed for R. lauricola In six collections from native species in the southeastern United States [Persea borbonia (L...
January 10, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28072845/tuberculosis-detection-in-paratuberculosis-vaccinated-calves-new-alternatives-against-interference
#20
Miriam Serrano, Natalia Elguezabal, Iker A Sevilla, María V Geijo, Elena Molina, Rakel Arrazuria, Alfonso Urkitza, Gareth J Jones, Martin Vordermeier, Joseba M Garrido, Ramón A Juste
Paratuberculosis vaccination in cattle has been restricted due to its possible interference with the official diagnostic methods used in tuberculosis eradication programs. To overcome this drawback, new possibilities to detect Mycobacterium bovis infected cattle in paratuberculosis vaccinated animals were studied under experimental conditions. Three groups of 5 calves each were included in the experiment: one paratuberculosis vaccinated group, one paratuberculosis vaccinated and M. bovis infected group and one M...
2017: PloS One
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