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https://www.readbyqxmd.com/read/29054805/factors-predicting-adherence-to-a-tailored-dose-adjuvant-treatment-on-the-basis-of-geriatric-assessment-in-elderly-people-with-colorectal-cancer-a-prospective-study
#1
Maite Antonio, Alberto Carmona-Bayonas, Juana Saldaña, Valentí Navarro, Cristian Tebé, Ramon Salazar, Josep Maria Borràs
BACKGROUND: Selecting elderly people with colorectal cancer (CRC) for adjuvant chemotherapy is challenging. Comprehensive geriatric assessment (CGA) can help by classifying them according to their frailty profile. The supposed benefit of chemotherapy is on the basis of the rate of treatment adherence. In this study we evaluated tolerance and adherence to tailored-dose adjuvant therapy on the basis of CGA in a cohort of older patients with high-risk stage II and stage III CRC. PATIENTS AND METHODS: This was a prospective study in 193 consecutive patients aged 75 years or older...
September 28, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29054600/microbe-dependent-induction-of-il-9-by-cla-t-cells-in-psoriasis-and-relationship-with-il-17a
#2
Ester Ruiz-Romeu, Marta Ferran, Carmen de Jesús-Gil, Pablo García, Marc Sagristà, J M Casanova, J M Fernández, Anca Chiriac, Péter Hóllo, Antonio Celada, Ramon M Pujol, Luis F Santamaria-Babí
IL-9 is present in psoriatic lesions and produced by lymphocytes. However, it is not known whether this cytokine is induced by relevant pathogenic triggers of psoriasis, such as Streptococcus pyogenes. Here we addressed the production of IL-9 in response to various pathogens in a psoriatic ex vivo model. Extracts of S. pyogenes and C. albicans triggered the production of IL-9 and also IL-17A and IFN-γ. This induction was dependent on the interaction between CLA(+) T-cells and epidermal cells. Neutralization of IL-9 reduced S...
October 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29054574/concepts-antecedents-and-consequences-of-ambulance-ramping-in-the-emergency-department-a-scoping-review
#3
Chris Kingswell, Ramon Z Shaban, Julia Crilly
BACKGROUND: Patients arriving at the Emergency Department (ED) via ambulance can experience a delay in receiving definitive care. In Australia, this phenomenon is referred to as 'Ambulance Ramping', 'Patient Off Stretcher Time Delay' or 'Offload Delay'. As a direct consequence of crowding, and in the context of a worldwide increase in ED and ambulance usage, hospital and ambulance service function is hampered. The aim of this review was to synthesize the literature with respect to the conceptualisation, meaning, antecedents and consequences of Ambulance Ramping...
October 17, 2017: Australasian Emergency Nursing Journal: AENJ
https://www.readbyqxmd.com/read/29053725/the-effects-of-training-with-loads-that-maximise-power-output-and-individualised-repetitions-vs-traditional-power-training
#4
J M Sarabia, M Moya-Ramón, J L Hernández-Davó, J Fernandez-Fernandez, R Sabido
BACKGROUND: It has been suggested that strength training effects (i.e. neural or structural) vary, depending on the total repetitions performed and velocity loss in each training set. PURPOSE: The aim of this study is to compare the effects of two training programmes (i.e. one with loads that maximise power output and individualised repetitions, and the other following traditional power training). METHODS: Twenty-five males were divided into three groups (optimum power [OP = 10], traditional training [TT = 9] and control group [CG = 6])...
2017: PloS One
https://www.readbyqxmd.com/read/29053415/low-concentration-of-5-fluorouracil-increases-the-effectiveness-of-tumor-rna-to-activate-murine-dendritic-cells
#5
Marcela Rodrigues de Camargo, Carolina Mendonça Gorgulho, Cecília Pessoa Rodrigues, Marcimara Penitenti, Juliana Cristina Longo Frederico, Maria Aparecida Marchesan Rodrigues, Ramon Kaneno
AIM: Considering the central role of dendritic cells (DCs) on the development of an antitumor immune response, in this study we used a murine model to evaluate how DC transfection with drug-treated tumor cell RNA changes their phenotype, and whether transfection enhances the in vivo effectiveness of a DC-based antitumor vaccine. MATERIALS AND METHODS: MC-38 colorectal tumor cells were pretreated with the minimum effective concentration of 5-fluorouracil (5-FU), then their total RNA was extracted and transfected into DCs...
October 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29053327/exact-identification-of-a-quantum-change-point
#6
Gael Sentís, John Calsamiglia, Ramon Muñoz-Tapia
The detection of change points is a pivotal task in statistical analysis. In the quantum realm, it is a new primitive where one aims at identifying the point where a source that supposedly prepares a sequence of particles in identical quantum states starts preparing a mutated one. We obtain the optimal procedure to identify the change point with certainty-naturally at the price of having a certain probability of getting an inconclusive answer. We obtain the analytical form of the optimal probability of successful identification for any length of the particle sequence...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29052374/portable-fluorescence-lifetime-spectroscopy-system-for-in-situ-interrogation-of-biological-tissues
#7
Marcelo Saito Nogueira, Alessandro Cosci, Ramon Gabriel Teixeira Rosa, Ana Gabriela Salvio, Sebastião Pratavieira, Cristina Kurachi
Fluorescence spectroscopy and lifetime techniques are potential methods for optical diagnosis and characterization of biological tissues with an in-situ, fast, and noninvasive interrogation. Several diseases may be diagnosed due to differences in the fluorescence spectra of targeted fluorophores, when, these spectra are similar, considering steady-state fluorescence, others may be detected by monitoring their fluorescence lifetime. Despite this complementarity, most of the current fluorescence lifetime systems are not robust and portable, and not being feasible for clinical applications...
October 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29052117/clinical-impact-of-an-interdisciplinary-patient-safety-program-for-managing-drug-related-problems-in-a-long-term-care-hospital
#8
Oreto Ruiz-Millo, Mónica Climente-Martí, Ana María Galbis-Bernácer, José Ramón Navarro-Sanz
Background Medication reviews intended to identify drug-related problems (DRPs) have been researched in primary care, acute care and nursing homes rather than in long-term care hospitals (LTCHs). Objectives To assess the clinical impact of an interdisciplinary pharmacotherapy quality improvement and patient safety program in elderly patients with polypharmacy admitted to an LTCH. Setting An interventional, longitudinal, prospective study was conducted in a Spanish LTCH Method A total of 162 elderly (≥ 70 years) patients with polypharmacy (≥ 5 medications) were included...
October 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29051270/hypoxia-induced-pd-l1-pd-1-crosstalk-impairs-t-cell-function-in-sleep-apnoea
#9
Carolina Cubillos-Zapata, Jose Avendaño-Ortiz, Enrique Hernandez-Jimenez, Victor Toledano, Jose Casas-Martin, Anibal Varela-Serrano, Marta Torres, Isaac Almendros, Raquel Casitas, Isabel Fernández-Navarro, Aldara Garcia-Sanchez, Luis A Aguirre, Ramón Farre, Eduardo López-Collazo, Francisco García-Rio
Obstructive sleep apnoea (OSA) is associated with higher cancer incidence, tumour aggressiveness and cancer mortality, as well as greater severity of infections, which have been attributed to an immune deregulation. We studied the expression of programmed cell death (PD)-1 receptor and its ligand (PD-L1) on immune cells from patients with OSA, and its consequences on immune-suppressing activity. We report that PD-L1 was overexpressed on monocytes and PD-1 was overexpressed on CD8(+) T-cells in a severity-dependent manner...
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29050635/from-the-editor-s-desk-november-2017
#10
Richard Moreau, Ramon Bataller, Thomas Berg, Jessica Zucmann-Rossi, Rajiv Jalan
No abstract text is available yet for this article.
November 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29048486/cancer-progression-models-and-fitness-landscapes-a-many-to-many-relationship
#11
Ramon Diaz-Uriarte
Motivation: The identification of constraints, due to gene interactions, in the order of accumulation of mutations during cancer progression can allow us to single out therapeutic targets. Cancer progression models (CPMs) use genotype frequency data from cross-sectional samples to identify these constraints, and return Directed Acyclic Graphs (DAGs) of restrictions where arrows indicate dependencies or constraints. On the other hand, fitness landscapes, which map genotypes to fitness, contain all possible paths of tumor progression...
October 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29048320/development-of-the-carmen-q-questionnaire-for-mental-workload-assessment
#12
Susana Rubio-Valdehita, María I López-Núñez, Ramón López-Higes, Eva M Díaz-Ramiro
BACKGROUND: Mental workload has emerged as one of the most important occupational risk factors present in most psychological and physical diseases caused by work. In view of the lack of specific tools to assess mental workload, the objective of this research was to assess the construct validity and reliability of a new questionnaire for mental workload assessment (CarMen-Q). METHOD: The sample was composed of 884 workers from several professional sectors, between 18 and 65 years old, 53...
November 2017: Psicothema
https://www.readbyqxmd.com/read/29046860/two-new-fluorogenic-aptasensors-based-on-capped-mesoporous-silica-nanoparticles-to-detect-ochratoxin%C3%A2-a
#13
Àngela Ribes, Sara Santiago-Felipe, Andrea Bernardos, M Dolores Marcos, Teresa Pardo, Félix Sancenón, Ramón Martínez-Máñez, Elena Aznar
Aptamers have been used as recognition elements for several molecules due to their great affinity and selectivity. Additionally, mesoporous nanomaterials have demonstrated great potential in sensing applications. Based on these concepts, we report herein the use of two aptamer-capped mesoporous silica materials for the selective detection of ochratoxin A (OTA). A specific aptamer for OTA was used to block the pores of rhodamine B-loaded mesoporous silica nanoparticles. Two solids were prepared in which the aptamer capped the porous scaffolds by using a covalent or electrostatic approach...
October 2017: ChemistryOpen
https://www.readbyqxmd.com/read/29046405/potato-consumption-does-not-increase-blood-pressure-or-incident-hypertension-in-2-cohorts-of-spanish-adults
#14
Emily A Hu, Miguel A Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Emilio Ros, Montse Fitó, Antonio Garcia-Rodriguez, Ramon Estruch, Fernando Arós, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Xavier Pintó, Miguel Ruiz-Canela, Cristina Razquin, Mònica Bulló, José V Sorlí, Helmut Schröder, Casey M Rebholz, Estefania Toledo
Background: Potatoes have a high glycemic load but also antioxidants, vitamins, and minerals. It is unclear what mechanisms are involved in relation to their effect on blood pressure (BP) and hypertension.Objectives: This study aimed to assess the association between potato consumption, BP changes, and the risk of hypertension in 2 Spanish populations.Methods: Separate analyses were performed in PREDIMED (PREvención con DIeta MEDiterránea), a multicenter nutrition intervention trial of adults aged 55-80 y, and the SUN (Seguimiento Universidad de Navarra) project, a prospective cohort made up of university graduates and educated adults with ages (means ± SDs) of 42...
October 18, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/29046296/geraniin-is-a-diuretic-by-inhibiting-the-na-k-2cl-cotransporter-nkcc2
#15
Erika Moreno, Juan A Gayosso, Jose Ramón Montejano, Georgina Almaguer, Norma Vázquez, Cristino Cruz, Adriana Mercado, Norma A Bobadilla, Gerardo Gamba, Alfredo Sierra, Victoria Ramírez
Geranium seemannii Peyr is a perennial plant endemic in central Mexico that has been widely used for its diuretic effect, but the responsible compound of this effect is unknown as well as the mechanism by which the diuretic effect is achieved. Geraniin is one of the compounds isolated from this kind of geranium. This study was designed to determinate whether geraniin possesses diuretic activity and to elucidate the mechanism of action. Geraniin was extracted and purified from Geranium seemannii Peyr. Male Wistar rats were divided into four groups: 1) Control, 2) 75 mg/kg of geraniin, 3) 20 mg/Kg of furosemide, and 4) 10 mg/Kg of hydrochlorothiazide...
October 18, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29045483/lipid-profile-cardiovascular-disease-and-mortality-in-a-mediterranean-high-risk-population-the-escarval-risk-study
#16
Domingo Orozco-Beltran, Vicente F Gil-Guillen, Josep Redon, Jose M Martin-Moreno, Vicente Pallares-Carratala, Jorge Navarro-Perez, Francisco Valls-Roca, Carlos Sanchis-Domenech, Antonio Fernandez-Gimenez, Ana Perez-Navarro, Vicente Bertomeu-Martinez, Vicente Bertomeu-Gonzalez, Alberto Cordero, Manuel Pascual de la Torre, Jose L Trillo, Concepcion Carratala-Munuera, Salvador Pita-Fernandez, Ruth Uso, Ramon Durazo-Arvizu, Richard Cooper, Gines Sanz, Jose M Castellano, Juan F Ascaso, Rafael Carmena, Maria Tellez-Plaza
INTRODUCTION: The potential impact of targeting different components of an adverse lipid profile in populations with multiple cardiovascular risk factors is not completely clear. This study aims to assess the association between different components of the standard lipid profile with all-cause mortality and hospitalization due to cardiovascular events in a high-risk population. METHODS: This prospective registry included high risk adults over 30 years old free of cardiovascular disease (2008-2012)...
2017: PloS One
https://www.readbyqxmd.com/read/29045423/candidemia-in-non-icu-surgical-wards-comparison-with-medical-wards
#17
Antonio Vena, Emilio Bouza, Maricela Valerio, Belén Padilla, José Ramón Paño-Pardo, Mario Fernández-Ruiz, Ana Díaz Martín, Miguel Salavert, Alessandra Mularoni, Mireia Puig-Asensio, Patricia Muñoz
Candidemia acquired outside critical care or hematological areas has received much attention in recent years; however, data on candidemia in surgical departments are very scarce. Our objectives were to describe episodes of candidemia diagnosed in surgical wards and to compare them with episodes occurring in medical wards. We performed a post hoc analysis of a prospective, multicenter study implemented in Spain during 2010-2011 (CANDIPOP project). Of the 752 episodes of candidemia, 369 (49.1%) occurred in patients admitted to surgical wards (165, 21...
2017: PloS One
https://www.readbyqxmd.com/read/29044515/the-human-pkp2-plakophilin-2-gene-is-induced-by-wnt-%C3%AE-catenin-in-normal-and-colon-cancer-associated-fibroblasts
#18
Núria Niell, María Jesús Larriba, Gemma Ferrer-Mayorga, Isabel Sánchez-Pérez, Ramón Cantero, Francisco X Real, Luis Del Peso, Alberto Muñoz, José Manuel González-Sancho
Colorectal cancer results from the malignant transformation of colonic epithelial cells. Stromal fibroblasts are the main component of the tumour microenvironment, and play an important role in the progression of this and other neoplasias. Wnt/β-catenin signalling is essential for colon homeostasis, but aberrant, constitutive activation of this pathway is a hallmark of colorectal cancer. Here we present the first transcriptomic study on the effect of a Wnt factor on human colonic myofibroblasts. Wnt3A regulates the expression of 1136 genes, of which 662 are upregulated and 474 are downregulated in CCD-18Co cells...
October 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29042165/sustained-ventricular-tachycardia-after-thoracic-traumatism-in-a-patient-with-repaired-tetralogy-of-fallot
#19
Isabel Molina Borao, Javier Urmeneta Ulloa, Naiara Calvo Galiano, Daniel Palanca Arias, Lorenzo Jiménez Montañés, Marta López Ramón
No abstract text is available yet for this article.
October 14, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29041496/demonstration-of-an-all-optical-feed-forward-delay-line-buffer-using-the-quadratic-stark-effect-and-two-photon-absorption-in-an-soa
#20
Horacio Soto, Miriam A Tong, Juan C Domínguez, Ramón Muraoka
We have inserted into an unbiased semiconductor optical amplifier (SOA) a powerful control beam, with photon energy slightly smaller than that of the band-gap of its active region, for exciting two-photon absorption and the quadratic Stark effect. For the available SOA, we estimated these phenomena generated a nonlinear absorption coefficient β= -865 cm/GW and induced an appreciable birefringence inside the amplifier waveguide, which significantly modified the polarization-state of a probe beam. Based on these effects, we have experimentally demonstrated the operation of an all-optical buffer, using an 80 Gb/s optical pulse comb, as well as an unbiased SOA, which was therefore, devoid of amplified spontaneous emission and pattern effects...
September 4, 2017: Optics Express
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