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https://www.readbyqxmd.com/read/28822913/polyphosphate-is-a-key-factor-for-cell-survival-after-dna-damage-in-eukaryotic-cells
#1
Samuel Bru, Bàrbara Samper-Martín, Eva Quandt, Sara Hernández-Ortega, Joan M Martínez-Laínez, Eloi Garí, Marta Rafel, Javier Torres-Torronteras, Ramón Martí, Mariana P C Ribeiro, Javier Jiménez, Josep Clotet
Cells require extra amounts of dNTPs to repair DNA after damage. Polyphosphate (polyP) is an evolutionary conserved linear polymer of up to several hundred inorganic phosphate (Pi) residues that is involved in many functions, including Pi storage. In the present article, we report on findings demonstrating that polyP functions as a source of Pi when required to sustain the dNTP increment essential for DNA repair after damage. We show that mutant yeast cells without polyP produce less dNTPs upon DNA damage and that their survival is compromised...
August 8, 2017: DNA Repair
https://www.readbyqxmd.com/read/28822744/aldosterone-renin-cardiovascular-events-and-all-cause-mortality-among-african%C3%A2-americans-the-jackson-heart-study
#2
Joshua J Joseph, Justin B Echouffo-Tcheugui, Rita R Kalyani, Hsin-Chieh Yeh, Alain G Bertoni, Valery S Effoe, Ramon Casanova, Mario Sims, Wen-Chih Wu, Gary S Wand, Adolfo Correa, Sherita H Golden
OBJECTIVES: This study examined the association of aldosterone and plasma renin activity (PRA) with incident cardiovascular disease (CVD), using a composite endpoint of coronary heart disease, stroke, and/or heart failure and mortality among African Americans in the Jackson Heart Study. BACKGROUND: There is a paucity of data for the association of aldosterone and PRA with incident CVD or all-cause mortality among community-dwelling African Americans. METHODS: A total of 4,985 African American adults, 21 to 94 years of age, were followed for 12 years...
August 3, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28822595/microbiological-assessment-of-honey-in-m%C3%A3-xico
#3
Carlos Ramón Vázquez-Quiñones, Rúben Moreno-Terrazas, Iván Natividad-Bonifacio, Elsa Irma Quiñones-Ramírez, Carlos Vázquez-Salinas
Honey is a product used as a natural sweetener and in several regions of Mexico and other countries it is also used as a therapeutic agent. Microbiological contamination of honey can occur during its extraction and handling. Due to the use and consumption of honey we highlighted here the importance of the assessment of its microbiological quality. One thousand nine hundred twenty samples obtained from 8 honey-producing states from Mexico were analyzed. From these samples, 40.5% (777/1920) did not comply with the NMX-036-NORMEX-2006 specification...
August 16, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28822355/baseline-assessment-of-25-hydroxyvitamin-d-assay-performance-a-vitamin-d-standardization-program-vdsp-interlaboratory-comparison-study
#4
Stephen Wise, Karen Phinney, Susan Tai, Johanna Camara, Gary Myers, Ramon Durazo-Arvizu, Lu Tian, Andrew Hoofnagle, Lorin Bachmann, Ian Young, Juanita Pettit, Grahame Caldwell, Andrew Liu, Stephen Brooks, Kurtis Sarafin, Michael Thamm, Gert Mensink, Markus Busch, Martina Rabenberg, Kevin Cashman, Mairead Kiely, Michael Kinsella, Karen Galvin, Joy Zhang, Kyungwon Oh, Sun-Wha Lee, Chae Jung, Lorna Cox, Gail Goldberg, Kate Guberg, Ann Prentice, Graham Carter, Julia Jones, Patsy Brannon, Robyn Lucas, Peter Crump, Etienne Cavalier, Joyce Merkel, Joseph Betz, Christopher Sempos
The Vitamin D Standardization Program (VDSP) coordinated an interlaboratory study to assess the comparability of measurements of total 25-hydroxyvitamin D [25(OH)D] in human serum, which is the primary marker of vitamin D status. A set of 50 individual donor samples were analyzed by 15 different laboratories representing national nutrition surveys, assay manufacturers, and clinical and/or research laboratories to provide results for total 25(OH)D using both immunoassays (IAs) and LC tandem MS (MS/MS). The results were evaluated relative to bias compared with the target values assigned based on a combination of measurements at Ghent University (Belgium) and the U...
August 19, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28821324/from-the-editor-s-desk-september-2017
#5
Richard Moreau, Ramon Bataller, Thomas Berg, Jessica Zucmann-Rossi, Rajiv Jalan
No abstract text is available yet for this article.
September 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28821067/optimization-of-high-purity-chitin-and-chitosan-production-from-illex-argentinus-pens-by-a-combination-of-enzymatic-and-chemical-processes
#6
José Antonio Vázquez, Diana Noriega, Patricia Ramos, Jesus Valcarcel, Ramon Novoa-Carballal, Lorenzo Pastrana, Rui L Reis, Ricardo I Pérez-Martín
The present report illustrates the optimisation of the experimental conditions for the chemical and enzymatic production of chitin and chitosan from Illex argentinus pen by-products. Optima conditions for chitin isolation were established at 0.82M NaOH/36.4°C, 57.5°C/pH=9.29, 59.6°C/pH=9.30 and 49.6°C/pH=5.91 for chemical, alcalase, esperase and neutrase deproteinization, respectively. Chitin samples were subsequently deacetylated by alkaline treatment reaching the highest degrees of deacetylation (DD>93%) at 61...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820555/satellite-atrial-septal-vegetations-secondary-to-mitral-valve-endocarditis
#7
Germán Cedielq, Marta Guillen Marzo, Ramón de Castro Aritmendiz, Jairo Toro Gil, Alfredo Bardají
Infective endocarditis is a challenging clinical problem with a high rate of mortality. Early recognition of this disease, and especially its complications, remain a critical task for the cardiologist. In this scenario, atrial endocarditis is a rare and sometimes unrecognized complication of mitral valve endocarditis. Herein is reported a clinical case that shows how a satellite vegetation in the atrial septum can be produced in a patient with mitral regurgitation secondary to mitral valve endocarditis. Video 1: Transthoracic echocardiography showing the presence of vegetation in the posterior mitral leaflet, severe secondary mitral regurgitation, and satellite vegetation in the atrial septum...
March 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28820342/expected-years-of-life-lost-through-road-traffic-injuries-in-mexico
#8
Efrén Murillo-Zamora, Oliver Mendoza-Cano, Benjamín Trujillo-Hernández, José Guzmán-Esquivel, Alfredo Medina-González, Miguel Huerta, Ramón Alberto Sánchez-Piña, Agustin Lugo-Radillo
BACKGROUND: Road traffic injuries (RTIs) are a leading cause of premature mortality, mainly in low- and middle-income countries Objective: To estimate the 2014 burden of RTIs in Mexico calculating years of life lost (YLL) and age-standardized YLL rates (ASYLL), and to evaluate sex, age, and region-related differences in premature mortality. METHODS: Mortality data were obtained from the National Institute of Statistics and Geography and 14,637 deaths of individuals 15 years of age and older were analyzed...
2017: Global Health Action
https://www.readbyqxmd.com/read/28816484/implementation-and-evaluation-of-a-parenting-program-to-prevent-child-maltreatment-in-suriname
#9
Inger W van der Kooij, Shandra Bipat, Frits Boer, Ramón J L Lindauer, Tobi L G Graafsma
The prevention of child maltreatment has become a global health concern because child maltreatment is a violation of children's rights. Across the world, a variety of parenting programs have been developed to address this problem. However, no such parenting program currently exists in Suriname. This pilot study aimed to implement Lobi Mi Pikin (LMP) parenting program in Suriname and to evaluate its effects on corporal punishment (CP) and child behavioral problems. Parents-caregivers (N = 70) of children (ages 3-12 years) with externalizing behavioral problems participated in a protocoled parenting program...
August 17, 2017: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/28816406/phosphinous-acid-assisted-hydration-of-nitriles-understanding-the-controversial-reactivity-of-osmium-and-ruthenium-catalysts
#10
Rebeca González-Fernández, Pascale Crochet, Victorio Cadierno, M Isabel Menéndez, Ramón López
The synthesis and catalytic behaviour of the osmium(II) complexes [OsCl2(6-p-cymene)(PR2OH)] [R = Me (2a), Ph (2b), OMe (2c), OPh (2d)] in nitrile hydration reactions is presented. Among them, the best catalytic results were obtained with the phosphinous acid derivative [OsCl2(6-p-cymene)(PMe2OH)] (2a), which selectively provided the desired primary amides in excellent yields and short times at 80 ºC, employing directly water as solvent, and without the assistance of any basic additive (TOF values up to 200 h-1)...
August 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28815842/in-situ-investigation-of-methane-dry-reforming-on-m-ceo2-111-m-co-ni-cu-surfaces-metal-support-interactions-and-the-activation-of-c-h-bonds-at-low-temperature
#11
Jose A Rodriguez, Zongyuan Liu, Pablo Lustemberg, Ramon Gutierrez, John Carey, Robert Palomino, Mykhailo Vorohta, David Grinter, Pedro Ramirez, Vladimir Matolin, Michael Nolan, M Veronica Ganduglia-Pirovano, Sanjaya Senanayake
Studies with a series of M-CeO2(111) {M= Co, Ni, Cu} surfaces indicate that metal-oxide interactions can play a very important role for the activation of methane and its reforming with CO2 at relatively low temperatures (600-700 K). Among the systems examined, Co-CeO2(111) exhibits the best performance and Cu-CeO2(111) has negligible activity. Experiments using ambient pressure XPS indicate that methane dissociates on Co-CeO2(111), at temperatures as low as 300 K, generating CHx and COx species on the catalyst surface...
August 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28815815/synthesis-optical-properties-and-dna-interaction-of-new-diquats-based-on-triazolopyridines-and-triazoloquinolines
#12
Pedro J Llabres-Campaner, Lluís Guijarro, Claudia Giarratano, Rafael Ballesteros-Garrido, Ramón J Zaragozá, M José Aurell, Enrique García-España, Rafael Ballesteros, Belén Abarca
New diquat derivatives based on [1,2,3]triazolo[1,5-a]pyridine and [1,2,3]triazolo[1,5-a]quinoline have been synthesized in excellent yields. To evaluate the effect of the alkyl bridge length, ethane and propane dibromo alkane substrates were used for their synthesis. Theoretical calculations predicted a very small energetic barrier between the two possible enantiomers P (Ra ) and M (Sa ), which makes them very difficult to resolve. Thermal denaturation studies, UV/Visible spectroscopy, and fluorescence titrations with ct-DNA evidenced the intercalation of the quinoline derivatives in DNA...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28815656/multiple-progressive-annular-telangiectasias-a-clinicopathological-variant-of-cutaneous-collagenous-vasculopathy
#13
Pablo García-Martínez, Ignacio Gomez-Martin, Josep Lloreta, Ramon M Pujol
Telangiectasias are the clinical manifestation of diverse processes affecting blood vessels. Herein we report the case of a 60-year-old man presenting long-standing asymptomatic annular telangiectatic lesions with whitish centers. The histopathologic examination revealed thickened blood dermal vessel walls in the superficial dermis showing reduplication of the basement membrane resembling cutaneous collagenous vasculopathy (CCV). We suggest that this atypical clinicopathological presentation may represent either a localized annular variant of CCV or a previously unreported clinical form of multiple cutaneous telangiectasias...
August 16, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28815135/active-deep-learning-based-annotation-of-electroencephalography-reports-for-cohort-identification
#14
Ramon Maldonado, Travis R Goodwin, Sanda M Harabagiu
The annotation of a large corpus of Electroencephalography (EEG) reports is a crucial step in the development of an EEG-specific patient cohort retrieval system. The annotation of multiple types of EEG-specific medical concepts, along with their polarity and modality, is challenging, especially when automatically performed on Big Data. To address this challenge, we present a novel framework which combines the advantages of active and deep learning while producing annotations that capture a variety of attributes of medical concepts...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28814398/plasma-lipidomic-profiles-and-cardiovascular-events-in-a-randomized-intervention-trial-with-the-mediterranean-diet
#15
Estefanía Toledo, Dong D Wang, Miguel Ruiz-Canela López, Clary B Clish, Cristina Razquin, Yan Zheng, Marta Guasch-Ferré, Adela Hruby, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, Ramón Estruch, Emilio Ros, José Lapetra, Montserrat Fito, Fernando Aros, Luis Serra-Majem, Liming Liang, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González
Background: Lipid metabolites may partially explain the inverse association between the Mediterranean diet (MedDiet) and cardiovascular disease (CVD).Objective: We evaluated the associations between 1) lipid species and the risk of CVD (myocardial infarction, stroke, or cardiovascular death); 2) a MedDiet intervention [supplemented with extra virgin olive oil (EVOO) or nuts] and 1-y changes in these molecules; and 3) 1-y changes in lipid species and subsequent CVD.Design: With the use of a case-cohort design, we profiled 202 lipid species at baseline and after 1 y of intervention in the PREDIMED (PREvención con DIeta MEDiterránea) trial in 983 participants [230 cases and a random subcohort of 790 participants (37 overlapping cases)]...
August 16, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28813442/a-parallel-metaheuristic-for-large-mixed-integer-dynamic-optimization-problems-with-applications-in-computational-biology
#16
David R Penas, David Henriques, Patricia González, Ramón Doallo, Julio Saez-Rodriguez, Julio R Banga
BACKGROUND: We consider a general class of global optimization problems dealing with nonlinear dynamic models. Although this class is relevant to many areas of science and engineering, here we are interested in applying this framework to the reverse engineering problem in computational systems biology, which yields very large mixed-integer dynamic optimization (MIDO) problems. In particular, we consider the framework of logic-based ordinary differential equations (ODEs). METHODS: We present saCeSS2, a parallel method for the solution of this class of problems...
2017: PloS One
https://www.readbyqxmd.com/read/28811918/shared-decision-making-in-medication-management-development-of-a-training-intervention
#17
Ute Stead, Nicola Morant, Shulamit Ramon
Shared decision-making is a collaborative process in which clinicians and patients make treatment decisions together. Although it is considered essential to patient-centred care, the adoption of shared decision-making into routine clinical practice has been slow, and there is a need to increase implementation. This paper describes the development and delivery of a training intervention to promote shared decision-making in medication management in mental health as part of the Shared Involvement in Medication Management Education (ShIMME) project...
August 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28811092/direct-oral-anticoagulants-in-patients-with-hypertrophic-cardiomyopathy-and-atrial-fibrillation
#18
Fernando Dominguez, Vicente Climent, Esther Zorio, Tomás Ripoll-Vera, Joel Salazar-Mendiguchía, Jose Manuel García-Pinilla, Jose Angel Urbano-Moral, Xusto Fernández-Fernández, David Lopez-Cuenca, Raquel Ajo-Ferrer, Jorge Sanz-Sanchez, Yolanda Gomez-Perez, Miguel A López-Garrido, Roberto Barriales-Villa, Juan Ramón Gimeno, Pablo Garcia-Pavia
BACKGROUND: Chronic anticoagulation with vitamin K antagonists (VKAs) is recommended in patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF). Direct oral anticoagulants (NOACs) are an alternative to VKAs but there are limited data to support their use in HCM. We sought to describe the pattern of use, thromboembolic events, bleeding and quality of life in patients with HCM and AF treated with NOACs. METHODS: Data from patients treated with NOACs (n=99) and VKA (n=433) at 9 inherited cardiac diseases units were retrospectively collected...
August 7, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28810892/absence-of-cx3cr1-impairs-the-internalization-of-tau-by-microglia
#19
Marta Bolós, María Llorens-Martín, Juan Ramón Perea, Jerónimo Jurado-Arjona, Alberto Rábano, Félix Hernández, Jesús Avila
BACKGROUND: Extracellular Tau is toxic for neighboring cells, and it contributes to the progression of AD. The CX3CL1/CX3CR1 axis is an important neuron/microglia communication mechanism. METHODS: We studied Tau clearance by microglia both in vitro (microglia primary cultures treated with Cy5-Tau, affinity chromatography to study the binding of Tau to CX3CR1, and Tau-CX3CL1 competition assays) and in vivo (stereotaxic injection of Cy5-Tau into WT and CX3CR1(-/-) mice)...
August 15, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28810730/hydrogen-isotope-fractionation-during-biodegradation-of-1-2-dichloroethane-potential-for-pathway-identification-using-a-multi-element-c-cl-and-h-isotope-approach
#20
Jordi Palau, Orfan Shouakar-Stash, Siti Hatijah Mortan, Rong Yu, Monica Rosell, Ernest Marco-Urrea, David L Freedman, Ramon Aravena, Albert Soler, Daniel Hunkeler
Even though multi-element isotope fractionation patterns provide crucial information to identify contaminant degradation pathways in the field, those involving hydrogen are still lacking for many halogenated groundwater contaminants and degradation pathways. This study investigates for the first time hydrogen isotope fractionation during both aerobic and anaerobic biodegradation of 1,2-dichloroethane (1,2-DCA) using five microbial cultures. Transformation-associated isotope fractionation values (ε_bulk^H) were: -115 ± 18‰ (aerobic C-H bond oxidation), -34 ± 4‰ and -38 ± 4‰ (aerobic C-Cl bond cleavage via hydrolytic dehalogenation), -57 ± 3‰ and -77 ± 9‰ (anaerobic C-Cl bond cleavage via reductive dihaloelimination)...
August 16, 2017: Environmental Science & Technology
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