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https://www.readbyqxmd.com/read/29231792/patient-selection-for-mechanical-thrombectomy-in-posterior-circulation-emergent-large-vessel-occlusion
#1
Scott Raymond, Natalia Sana Rost, Pamela Whitney Schaefer, Thabele Leslie-Mazwi, Joshua A Hirsch, Ramon Gilberto Gonzalez, James Rabinov
Triage of posterior circulation stroke from emergent large-vessel occlusion (pc-ELVO) is challenging owing to the stuttering clinical course and potential for rapid decline. Growing clinical data support the use of mechanical thrombectomy in pc-ELVO, but there are limited data addressing the clinical and imaging criteria for patient selection. We present our triage algorithm used to select patients for endovascular therapy (EVT) in the setting of pc-ELVOS. We use a consecutive retrospective database from 2004 to 2016 to describe the practice patterns and prognostic factors for pc-ELVO patients treated using both medical and EVT...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29230948/three-dimensional-printed-model-of-bilateral-wilms-tumor-a-useful-tool-for-planning-nephron-sparing-surgery
#2
Óscar Girón-Vallejo, Darío García-Calderón, Ramón Ruiz-Pruneda, Rosa Cabello-Laureano, Ernesto Doménech-Abellán, José Luis Fuster-Soler, José I Ruiz-Jiménez
Nephron sparing surgery (NSS) is increasingly utilized to treat patients with bilateral Wilms tumor. We present a case of NSS planning using a three-dimensional computerized and printed model of both kidneys with anatomical structures of interest (parenchyma, renal pelvis, major calyx, renal artery, renal vein, and tumor). This model allowed a better understanding of the anatomic relation between the tumor and the normal kidney on each side, improving the surgical planning and the preoperative discussion with the patient's family...
December 12, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29230283/repair-of-giant-inguinoscrotal-hernia-with-loss-of-domain
#3
Erion Qaja, Carol Le, Ramon Benedicto
A massive inguinoscrotal hernia extending below the midpoint of the inner thigh, in a standing position, constitute a 'giant' inguinoscrotal hernia. A 74-year-old male presented with giant left sided inguinal hernia for the last 30 years. Patient underwent open repair under general anesthesia after perioperative respiratory exercise. Standard hernia repair identified a sliding hernia containing entire omentum, small and large bowel, and the appendix. Giant hernias pose a challenging problem because reduction of the hernia contents inside the abdominal cavity may increase intra-abdominal and thoracic pressures...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29230224/lipoarabinomannan-decreases-galectin-9-expression-and-tumor-necrosis-factor-pathway-in-macrophages-favoring-mycobacterium-tuberculosis-intracellular-growth
#4
Leslie Chávez-Galán, Lucero Ramon-Luing, Claudia Carranza, Irene Garcia, Isabel Sada-Ovalle
Lipoarabinomannan (LAM) is a lipid virulent factor secreted by Mycobacterium tuberculosis (Mtb). LAM can be found in the sputum and urine of patients with active tuberculosis. When human monocytes are differentiated into macrophages [monocyte-derived macrophages (MDM)] in the presence of LAM, MDM are poorly functional which may limit the immune response to Mtb infection. Our previous studies have shown that TIM3 and galectin (GAL)9 interaction induces anti-mycobacterial activity, and the expression levels of TIM3 and GAL9 are downregulated during Mtb infection...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29228322/tlr9-stimulation-induces-increase-in-fungicidal-activity-of-human-dendritic-cells-challenged-with-paracoccidioides-brasiliensis
#5
Ivy Rafacho Vieira, Reginaldo Keller Fernandes, Daniela Ramos Rodrigues, Carolina Mendonça Gorgulho, Ramon Kaneno, Ângela Maria Victoriano Campos Soares
Microorganisms killing by dendritic cells (DCs) is an important effector mechanism during innate immune response, as it can avoid dissemination of infection during migration of these cells toward draining lymph nodes. However, this function depends on pattern recognition receptors (PRRs) to which the microorganism will bind in these cells. Regarding this, TLR9 activation, by stimulating the oxidative metabolism, induces increase in microbicidal activity of these cells. Accordingly, we showed that DCs treatment with a TLR9 agonist results in an increase in fungicidal activity of these cells against the fungus Paracoccidioides brasiliensis (Pb), which however, was not associated to higher H2O2 levels...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29227345/response-percutaneous-vascular-interventions-versus-bypass-surgeries-in-patients-with-critical-limb-ischemia
#6
Sharath C V Paravastu, Shannon D Thomas, Ramon L Varcoe
No abstract text is available yet for this article.
December 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29226819/adherence-to-mediterranean-diet-and-all-cause-mortality-after-an-episode-of%C3%A2-acute-heart-failure-results-of-the%C3%A2-medit-ahf%C3%A2-study
#7
Òscar Miró, Ramon Estruch, Francisco J Martín-Sánchez, Víctor Gil, Javier Jacob, Pablo Herrero-Puente, Sergio Herrera Mateo, Alfons Aguirre, Juan A Andueza, Pere Llorens
OBJECTIVES: The authors sought to evaluate clinical outcomes of patients after an episode of acute heart failure (AHF) according to their adherence to the Mediterranean diet (MedDiet). BACKGROUND: It has been proved that MedDiet is a useful tool in primary prevention of cardiovascular diseases. However, it is unknown whether adherence to MedDiet is associated with better outcomes in patients who have already experienced an episode of AHF. METHODS: We designed a prospective study that included consecutive patients diagnosed with AHF in 7 Spanish emergency departments (EDs)...
November 27, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29223229/comparison-of-a-new-scheimpflug-imaging-combined-with-partial-coherence-interferometry-biometer-and-a-low-coherence-reflectometry-biometer
#8
Ramón Ruiz-Mesa, Antonio Abengózar-Vela, María Ruiz-Santos
PURPOSE: To evaluate the repeatability of a new biometer using Scheimpflug technology combined with partial coherence interferometry (PCI) (Pentacam AXL) and its agreement with a device based on optical low-coherence reflectometry (OLCR), the Allegro Biograph. SETTING: Oftalvist Centro Integral Ocular Jerez, Jerez de la Frontera, Spain. DESIGN: Evaluation of a diagnostic test. METHODS: The mean keratometry (K), central corneal thickness (CCT), anterior chamber depth (ACD), and axial length (AL) were measured with the 2 devices 3 times by the same examiner in 2 groups (patients with cataract and patients without cataract)...
November 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29222849/bone-marrow-transplantation-improves-motor-activity-in-a-mouse-model-of-ataxia
#9
David Díaz, Marina Piquer-Gil, Javier Sánchez Recio, María Magdalena Martínez-Losa, José Ramón Alonso, Eduardo Weruaga, Manuel Álvarez-Dolado
Ataxias are locomotor disorders that can have an origin both neural and muscular, although both impairments are related. Unfortunately, ataxia has no cure and the current therapies are aimed at motor re-education or muscular reinforcement. Nevertheless, cell therapy is becoming a promising approach to deal with incurable neural diseases, including neuro-muscular ataxias. Here we have used a model of ataxia, the PCD mutant mouse, to study the effect of healthy (wild-type) bone marrow transplantation on the restoration of defective mobility...
December 8, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29221813/neonatal-programming-with-testosterone-propionate-reduces-dopamine-transporter-expression-in-nucleus-accumbens-and-methylphenidate-induced-locomotor-activity-in-adult-female-rats
#10
Tatiana Dib, Jonathan Martínez-Pinto, Miguel Reyes-Parada, Gonzalo E Torres, Ramón Sotomayor-Zárate
Research in programming is focused on the study of stimuli that alters sensitive periods in development, such as prenatal and neonatal stages, that can produce long-term deleterious effects. These effects can occur in various organs or tissues such as the brain, affecting brain circuits and related behaviors. Our laboratory has demonstrated that neonatal programming with sex hormones affects the mesocorticolimbic circuitry, increasing the synthesis and release of dopamine (DA) in striatum and nucleus accumbens (NAcc)...
December 5, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29221619/economic-susceptibility-of-fire-prone-landscapes-in-natural-protected-areas-of-the-southern-andean-range
#11
Juan Ramón Molina, Roberto Moreno, Miguel Castillo, Francisco Rodríguez Y Silva
Large fires are the most important disturbances at landscape-level due to their ecological and socioeconomic impacts. This study aimed to develop an approach for the assessment of the socio-economic landscape susceptibility to fire. Our methodology focuses on the integration of economic components of landscape management based on contingent valuation method (CVM) and net-value change (NVC). This former component has been estimated using depreciation rates or changes on the number of arrivals to different natural protected areas after a large fire occurrence...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29221409/the-gas-phase-structure-of-%C3%AE-pinene-a-main-biogenic-volatile-organic-compound
#12
Elias M Neeman, Juan Ramón Avilés Moreno, Thérèse R Huet
The gas phase structure of the bicyclic atmospheric aerosol precursor α-pinene was investigated employing a combination of quantum chemical calculation and Fourier transform microwave spectroscopy coupled to a supersonic jet expansion. The very weak rotational spectra of the parent species and all singly substituted 13C in natural abundance have been identified, from 2 to 20 GHz, and fitted to Watson's Hamiltonian model. The rotational constants were used together with geometrical parameters from density functional theory and ab initio calculations to determine the rs, r0, and rm(1) structures of the skeleton, without any structural assumption in the fit concerning the heavy atoms...
December 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29219923/multimodal-use-of-fluorescent-imaging-in-colorectal-cancer-surgery
#13
Deborah S Keller, Juan Ramon Flores Gonzalez, Manish Chand
No abstract text is available yet for this article.
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29219406/efficient-low-order-approximation-of-first-passage-time-distributions
#14
David Schnoerr, Botond Cseke, Ramon Grima, Guido Sanguinetti
We consider the problem of computing first-passage time distributions for reaction processes modeled by master equations. We show that this generally intractable class of problems is equivalent to a sequential Bayesian inference problem for an auxiliary observation process. The solution can be approximated efficiently by solving a closed set of coupled ordinary differential equations (for the low-order moments of the process) whose size scales with the number of species. We apply it to an epidemic model and a trimerization process and show good agreement with stochastic simulations...
November 24, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29218390/gemelli-obturator-complex-in-the-deep-gluteal-space-an-anatomic-and-dynamic-study
#15
Ramon Balius, Antonio Susín, Carles Morros, Montse Pujol, Dolores Pérez-Cuenca, Xavier Sala-Blanch
OBJECTIVE: To investigate the behavior of the sciatic nerve during hip rotation at subgluteal space. MATERIALS AND METHODS: Sonographic examination (high-resolution ultrasound machine at 5.0-14 MHZ) of the gemelli-obturator internus complex following two approaches: (1) a study on cadavers and (2) a study on healthy volunteers. The cadavers were examined in pronation, pelvis-fixed position by forcing internal and external rotations of the hip with the knee in 90° flexion...
December 7, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29218033/substrate-limited-and-unlimited-coastal-microbial-communities-show-different-metabolic-responses-with-regard-to-temperature
#16
Helmut Maske, Ramón Cajal-Medrano, Josué Villegas-Mendoza
Bacteria are the principal consumers of dissolved organic carbon (DOC) in the ocean and predation of bacteria makes organic carbon available to higher trophic levels. The efficiency with which bacteria convert the consumed carbon (C) into biomass (i.e., carbon growth efficiency, Y) determines their ecological as well as biogeochemical role in marine ecosystems. Yet, it is still unclear how changes in temperature will affect Y and, hence, the transfer of consumed C to higher trophic levels. Here, we experimentally investigated the effect of temperature on metabolic functions of coastal microbial communities inoculated in both nutrient-limited chemostats and nutrient-unlimited turbidostats...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29216997/the-state-of-the-absorb-bioresorbable%C3%A2-scaffold-consensus-from-an-expert-panel
#17
REVIEW
Sripal Bangalore, Hiram G Bezerra, David G Rizik, Ehrin J Armstrong, Bruce Samuels, Srihari S Naidu, Cindy L Grines, Malcolm T Foster, James W Choi, Barry D Bertolet, Atman P Shah, Rebecca Torguson, Surendra B Avula, John C Wang, James P Zidar, Aziz Maksoud, Arun Kalyanasundaram, Steven J Yakubov, Bassem M Chehab, Anthony J Spaedy, Srini P Potluri, Ronald P Caputo, Ashok Kondur, Robert F Merritt, Amir Kaki, Ramon Quesada, Manish A Parikh, Catalin Toma, Fadi Matar, Joseph DeGregorio, William Nicholson, Wayne Batchelor, Raghava Gollapudi, Ethan Korngold, Riyaz Sumar, George S Chrysant, Jun Li, John B Gordon, Rajesh M Dave, Guilherme F Attizzani, Tom P Stys, Osvaldo S Gigliotti, Bruce E Murphy, Stephen G Ellis, Ron Waksman
Significant progress has been made in the percutaneous coronary intervention technique from the days of balloon angioplasty to modern-day metallic drug-eluting stents (DES). Although metallic stents solve a temporary problem of acute recoil following balloon angioplasty, they leave behind a permanent problem implicated in very late events (in addition to neoatherosclerosis). BRS were developed as a potential solution to this permanent problem, but the promise of these devices has been tempered by clinical trials showing increased risk of safety outcomes, both early and late...
December 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29216831/validity-of-mobile-electronic-data-capture-in-clinical-studies-a-pilot-study-in-a-pediatric-population
#18
Belinda von Niederhäusern, Ramon Saccilotto, Sabine Schädelin, Victoria Ziesenitz, Pascal Benkert, Marie-Luise Decker, Anya Hammann, Julia Bielicki, Marc Pfister, Christiane Pauli-Magnus
BACKGROUND: Clinical studies in children are necessary yet conducting multiple visits at study centers remains challenging. The success of "care-at-home" initiatives and remote clinical trials suggests their potential to facilitate conduct of pediatric studies. This pilot aimed to study the feasibility of remotely collecting valid (i.e. complete and correct) saliva samples and clinical data utilizing mobile technology. METHODS: Single-center, prospective pilot study in children undergoing elective tonsillectomy at the University of Basel Children's Hospital...
December 8, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29215877/gas-phase-acidities-and-basicities-of-alanines-and-n-benzyl-alanines-by-the-extended-kinetic-method
#19
Rafael Notario, Juan Zenon Davalos, Prof Eusebio Juaristi, Ramón Guzmán-Mejía
This paper reports an experimental determination of the gas-phase acidities and basicities of N-benzylalanines, in both their α and β forms, by means of the Extended Kinetic Method (EKM). The experimental gas-phase acidity of β-alanine was also determined. Standard ab initio molecular orbital calculations at the G3 level were performed for alanines, and at the G3(MP2)//B3LYP level for N-benzylalanines. There is a very good agreement between the experimental and the calculated values. The more branched α-amino acids are more acidic and less basic than the linear β-amino acids...
December 7, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29214974/insights-into-the-candidacidal-mechanism-of-ctn-15-34-a-carboxyl-terminal-crotalicidin-derived-peptide-related-to-cathelicidins
#20
Carolina Sidrim P Cavalcante, Francisca Lidiane Linhares de Aguiar, Raquel O S Fontenelle, Ramon Roseo de P P B de Menezes, Alice Maria Costa Martins, Cláudio B Falcão, David Andreu, Gandhi Rádis-Baptista
PURPOSE: Ctn[15-34], a carboxyl-terminal fragment of crotalicidin (a cathelicidin from the venom gland of a South American rattlesnake), has shown antifungal activity against clinical and standard strains of Candida species. The aim of the present work was to investigate the underlying mechanisms of the candidicidal activity of Ctn[15-34]. METHODOLOGY: The time-kill profile and drug synergism were evaluated by means of a microdilution assay and multi-parametric flow cytometry...
December 7, 2017: Journal of Medical Microbiology
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