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José Luis Martín-Varillas, Vanesa Calvo-Río, Emma Beltrán, Juan Sánchez-Bursón, Marina Mesquida, Alfredo Adán, María Victoria Hernandez, Marisa Hernández Garfella, Elia Valls Pascual, Lucía Martínez-Costa, Agustí Sellas-Fernández, Miguel Cordero-Coma, Manuel Díaz-Llopis, Roberto Gallego, David Salom, Norberto Ortego, José L García-Serrano, José-Luis Callejas-Rubio, José M Herreras, Ángel García-Aparicio, Olga Maíz, Ana Blanco, Ignacio Torre, David Díaz-Valle, Esperanza Pato, Elena Aurrecoechea, Miguel A Caracuel, Fernando Gamero, Enrique Minguez, Carmen Carrasco-Cubero, Alejandro Olive, Julio Vázquez, Oscar Ruiz-Moreno, Javier Manero, Santiago Muñoz-Fernández, Myriam Gandía Martinez, Esteban Rubio-Romero, F Javier Toyos-Sáenz de Miera, Francisco Javier López Longo, Joan M Nolla, Marcelino Revenga, Carmen González-Vela, Javier Loricera, Belén Atienza-Mateo, Rosalía Demetrio-Pablo, José Luis Hernández, Miguel A González-Gay, Ricardo Blanco
PURPOSE: To assess efficacy, safety, and cost-effectiveness of adalimumab (ADA) therapy optimization in a large series of patients with uveitis due to Behçet disease (BD) who achieved remission after the use of this biologic agent. DESIGN: Open-label multicenter study of ADA-treated patients with BD uveitis refractory to conventional immunosuppressants. SUBJECTS: Sixty-five of 74 patients with uveitis due to BD, who achieved remission after a median ADA duration of 6 (range, 3-12) months...
March 27, 2018: Ophthalmology
Xiang Li, Yue Wu, Yanyan Wang, Qidong You, Xiaojin Zhang
DDO-6101, a natural-product-like caged xanthone discovered previously in our laboratory based on the pharmacophoric scaffold of the Garcinia natural product gambogic acid (GA), shows potent cytotoxicity in vitro, but poor efficacy in vivo due to its poor druglike properties. In order to improve the druglike properties and in vivo antitumor potency, a novel series of ten triazole-bearing caged xanthone derivatives of DDO-6101 has been efficiently synthesized by 'click chemistry' and evaluated for their in vitro antitumor activity and druglike properties...
October 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
F G Teixeira, O T Hamawaki, A P O Nogueira, R L Hamawaki, G L Jorge, C L Hamawaki, B Q V Machado, A J O Santana
Defining selection criteria is important to obtain promising genotypes in a breeding program. The objective of this study was to estimate genetic parameters for agronomic traits and to perform soybean line selection using selection indices. The experiment was conducted at an experimental area located at Capim Branco farm, belonging to the Federal University of Uberlândia. A total of 37 soybean genotypes were evaluated in randomized complete block design with three replicates, in which twelve agronomic traits were evaluated...
September 21, 2017: Genetics and Molecular Research: GMR
Nicole J Tarlton, Tiffany S Satoorian, Anand Panchal, Clarissa A Borges, Mark Geisberg, Lee W Riley
Gram-negative bacteria (GNB) that express CTX-M β-lactamases have become a serious threat to the clinical management of GNB infections. While antibody-based platforms have been successfully used in research settings to study and detect other β-lactamases-including SHV, CMY, and TEM enzymes-there is currently a lack of antibody-based tools to detect the CTX-M enzymes. Here we describe the development of an anti-CTX-M sandwich ELISA based on a pair of monoclonal antibodies (mAbs)-mAb 6101-33 and mAb 6101-19-used as the capture and detection antibody, respectively...
January 2018: Journal of Microbiological Methods
Michelle M Amaral, William E Herrin, Grace Bulenzi Gulere
BACKGROUND: The United Nations' Millennium Development Goals Report, 2015, documents that, since 1990, the number of stunted children in sub-Saharan Africa has increased by 33% even though it has fallen in all other world regions. Recognizing this, in 2011 the Government of Uganda implemented a 5-year Nutrition Action Plan. One important tenet of the Plan is to lessen malnutrition in young children by discouraging over-consumption of nutritionally deficient, but plentiful, staple foods, which it defines as a type of food insecurity...
July 19, 2017: BMC Public Health
Xiaorui Sun, Pengfei Jiang, Wenliang Gao, Xianju Zhou, Rihong Cong, Tao Yang
Rare-earth borates are good candidates for optical applications. To date, however, the high-pressure/high-temperature technique has produced a large number of novel borates with optical properties that have rarely been investigated due to the severe problem of substantial defects. We targeted the high-pressure polymorph of β-GdB3 O6 and synthesized three solid solutions of β-Gd0.75-x Bi0.25 Tbx B3 O6 (0≤x≤0.75), β-Gd0.75-y Bi0.25 Euy B3 O6 (0≤y≤0.75), and β-Gd0.50-z Bi0.25 Tb0.25 Euz B3 O6 (0≤z≤0...
June 19, 2017: Chemistry, An Asian Journal
Xiaoli Xu, Yue Wu, Mingyang Hu, Xiang Li, Qichao Bao, Jinlei Bian, Qidong You, Xiaojin Zhang
DDO-6101, a simplified structure obtained from the Garcinia natural product (NP) gambogic acid (GA), has been previously shown to possess high cytotoxicity to a variety of human tumour cell lines. To improve its physicochemical properties and in vivo cytotoxic potency, a series of novel carbamate-bearing derivatives based on DDO-6101 was synthesized and characterized. The structural modifications revealed that the presence of a carbamate moiety was useful for obtaining comparable cytotoxicity and improved aqueous solubility and permeability...
October 21, 2016: Scientific Reports
Madhulata Kumari, Subhash Chandra, Neeraj Tiwari, Naidu Subbarao
BACKGROUND: The Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) is only aspartyl aminopeptidase which is found in the genome of P. falciparum and is essential for its survival. The PfM18AAP enzyme performs various functions in the parasite and the erythrocytic host such as hemoglobin digestion, erythrocyte invasion, parasite growth and parasite escape from the host cell. It is a valid target to develop antimalarial drugs. In the present work, we employed 3D QSAR modeling, pharmacophore modeling, and molecular docking to identify novel potent inhibitors that bind with M18AAP of P...
August 17, 2016: BMC Structural Biology
Ekua Yorke, Noah Jacob Switzer, Artan Reso, Xinhe Shi, Christopher de Gara, Daniel Birch, Richdeep Gill, Shahzeer Karmali
Older models of intragastric balloons (IGBs) had unacceptably high complication rates and inconsequential weight loss. With FDA approval of newer models, we aimed to systematically examine the literature regarding the efficacy of IGB therapy for obesity. A comprehensive electronic database search was completed. Title searching was restricted to the following keywords: bariatric, gastric, gastric bypass, gastric band, sleeve gastrectomy, and intragastric balloon. Twenty-six primary studies (n = 6101) were included...
September 2016: Obesity Surgery
Guo-Lin Xiong, Xing Shen, Xiao-Lan Liu, Meng Yang, Chang-Liang Dai, Xiao-Yu Liu, Shuang Xing, Zu-Yin Yu
OBJECTIVE: To investigate the effects of HS 6101 and recombinant human granulocyte colony stimulating factor (rhG-CSF) on hematopoiesis recovery of ICR mice injured by cyclophosphamide (CTX). METHODS: A total of 103 ICR mice were divided into 4 groups, including CTX control (46 mice), HS 6101 (21 mice), rhG-CSF (18 mice) and HS 6101+rhG-CSF (18 mice), respectively. The mouse model of chemotherapy-induced haematopoietic injury was established by CTX intraperitoneal injection at a dose of 100 mg/kg once a day for 3 consecutive days...
December 2015: Zhongguo Shi Yan Xue Ye Xue za Zhi
L B Sousa, O T Hamawaki, A P O Nogueira, R O Batista, V M Oliveira, R L Hamawaki
In the final phases of new soybean cultivar development, lines are cultivated in several locations across multiple seasons with the intention of identifying and selecting superior genotypes for quantitative traits. In this context, this study aimed to study the genotype-by-environment interaction for the trait grain yield (kg/ha), and to evaluate the adaptability and stability of early-cycle soybean genotypes using the additive main effects and multiplicative interaction (AMMI) analysis, genotype main effects and genotype x environment interaction (GGE) biplot, and factor analysis methods...
2015: Genetics and Molecular Research: GMR
Yue Wu, Mingyang Hu, Li Yang, Xiang Li, Jinlei Bian, Fen Jiang, Haopeng Sun, Qidong You, Xiaojin Zhang
DDO-6101, a natural-product-like caged xanthone discovered previously in our laboratory based on the pharmacophoric scaffold of Garcinia natural product gambogic acid (GA), shows potent cytotoxicity in vitro but poor efficacy in vivo due to its poor druglike properties. In order to improve the druglike properties and in vivo cytotoxic potency, a novel series of 19 prenyl group-modified derivatives of DDO-6101 was synthesized and evaluated for their in vitro antitumor activity and druglike properties. The SAR and SPR information of these compounds was also obtained...
June 15, 2015: Bioorganic & Medicinal Chemistry Letters
Zheng-Xia Chen, Hong-Gang Ni, Xin Jing, Wen-Jing Chang, Jian-Lin Sun, Hui Zeng
Fine roots of woody plants are a heterogeneous system differing markedly in structure and function. Nevertheless, knowledge about the plant uptake of organic pollutants via fine roots is scarce to date. In the present study, plant uptake, translocation, and return of polycyclic aromatic hydrocarbons (PAHs) via fine roots in a subtropical forest ecosystem were investigated. Levels of Σ15PAHs in different fine root branch orders of Michelia macclurei, Cryptocarya concinna, Cryptocarya chinensis, and Canthium dicoccums varied from 5072±1419 ng g(-1) to 6080±1656 ng g(-1), 4037±410 ng g(-1) to 6101±972 ng g(-1), 3308±1191 ng g(-1) to 4283±237 ng g(-1), and 3737±800 ng g(-1) to 4895±1216 ng g(-1), respectively...
July 2015: Chemosphere
Xing Shen, Shuang Xing, Guo-Lin Xiong, Ling Xie, Ling-Ling Guo, Zheng-Liang Qiu, Chang-Hui Ge, Chang-Liang Dai, Qing-Liang Luo, Xiao-Yu Liu, Zu-Yin Yu
This study was purposed to investigate the protective effects of lipoprotein HS-6101(6101) on rhesus monkey total body irradiated with 7.0 Gy ⁶⁰Coγ-ray. A total of 30 health adult rhesus monkeys were randomly divided into symptomatic therapy (ST), WR2721 and HS-6101 30, 90 and 270 mg/kg groups (n = 6), the rhesus monkeys of each groups were injected with physiological saline 0.3 ml/kg, WR-2721 30 mg/kg, or HS-6101 30, 90 and 270 µg/kg, respectively. All agents were once intramuscularly injected at 1 hr prior irradiation...
December 2014: Zhongguo Shi Yan Xue Ye Xue za Zhi
Michael J Lanspa, Justin Dickerson, Alan H Morris, James F Orme, John Holmen, Eliotte L Hirshberg
INTRODUCTION: Both patient- and context-specific factors may explain the conflicting evidence regarding glucose control in critically ill patients. Blood glucose variability appears to correlate with mortality, but this variability may be an indicator of disease severity, rather than an independent predictor of mortality. We assessed blood glucose coefficient of variation as an independent predictor of mortality in the critically ill. METHODS: We used eProtocol-Insulin, an electronic protocol for managing intravenous insulin with explicit rules, high clinician compliance, and reproducibility...
April 30, 2014: Critical Care: the Official Journal of the Critical Care Forum
Cuauhtemoc Licona-Cassani, Sooa Lim, Esteban Marcellin, Lars K Nielsen
Actinomycetes undergo a dramatic reorganization of metabolic and cellular machinery during a brief period of growth arrest ("metabolic switch") preceding mycelia differentiation and the onset of secondary metabolite biosynthesis. This study explores the role of phosphorylation in coordinating the metabolic switch in the industrial actinomycete Saccharopolyspora erythraea. A total of 109 phosphopeptides from 88 proteins were detected across a 150-h fermentation using open-profile two-dimensional LC-MS proteomics and TiO(2) enrichment...
May 2014: Molecular & Cellular Proteomics: MCP
Simone A Johner, Michael Thamm, Peter Stehle, Ute Nöthlings, Eugen Kriener, Henry Völzke, Roland Gärtner, Thomas Remer
BACKGROUND: Worldwide, iodine prophylaxis measures have improved iodine status in populations. Several studies have reported an increase in thyrotropin (TSH) levels coinciding with this prophylaxis. Whether this implies an increased risk for hypothyroidism or simply reflects a physiologic TSH adaptation mechanism is not clear. METHODS: Data on iodine and thyroid status of 6-17 year old children and adolescents (n=9175), collected between 2003 and 2006 in the German-wide Health Interview and Examination Survey for Children and Adolescents (KiGGS) Study, provided the basis for the analyses of mutual relationships of urinary iodine status (assessed by iodine/creatinine ratio in spot urines), serum TSH levels, and thyroid volume (determined by ultrasound)...
July 2014: Thyroid: Official Journal of the American Thyroid Association
Matthew Marino, Horace Spencer, Sam Hohmann, Donald Bodenner, Brendan C Stack
OBJECTIVE: To compare the cost of same-day vs 23-hour observation outpatient thyroidectomy at US academic medical centers. STUDY DESIGN: Cross-sectional analysis of a national database. SETTING: The University HealthSystem Consortium (UHC) data collected from discharge summaries. SUBJECTS AND METHODS: Discharge data were collected from the first quarter of 2009 through the second quarter of 2013. The UHC database, compiled from more than 200 affiliated hospitals, was searched based on diagnosis codes for outpatient thyroid procedures...
May 2014: Otolaryngology—Head and Neck Surgery
Yi Ding, Dandan He, Diego Florentin, Anna Frolov, Sue Hilsenbeck, Michael Ittmann, Dov Kadmon, Brian Miles, David Rowley, Gustavo Ayala
BACKGROUND: Semaphorin 4F (S4F) has roles in embryologic axon guidance and is expressed in adults. S4F is involved in cancer-induced neurogenesis. METHODS: Prostate cells were transfected with S4F retrovirus. Cells and controls were used for a bromodeoxyuridine (BrdUrd) incorporation assay (proliferation) and in vitro scratch and Matrigel Transwell chamber invasion assay (migration). Monoclonal antibodies were developed using baculovirus-expressed recombinant GST-S4F and used to immunostain tissue microarrays...
November 15, 2013: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Y-S Chao, L Brunel, P Faris, P J Veugelers
BACKGROUND: Vitamin D deficiency and insufficiency are prevalent worldwide, but relatively few studies have examined vitamin D status in working populations. AIMS: To assess the prevalence of vitamin D deficiency and insufficiency in Canadian workers and investigate risk factors in this population. METHODS: A cross-sectional study using data from a health programme enrolling workers mostly from Northern Alberta, Canada. As part of the programme, volunteers were invited to complete a lifestyle questionnaire...
October 2013: Occupational Medicine
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