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https://www.readbyqxmd.com/read/28873086/anti-mullerian-hormone-and-endometrial-cancer-a-multi-cohort-study
#1
Renée T Fortner, Helena Schock, Seungyoun Jung, Naomi E Allen, Alan A Arslan, Louise A Brinton, Brian L Egleston, Roni T Falk, Marc J Gunter, Kathy J Helzlsouer, Annika Idahl, Theron S Johnson, Rudolf Kaaks, Vittorio Krogh, Eva Lundin, Melissa A Merritt, Carmen Navarro, N Charlotte Onland-Moret, Domenico Palli, Xiao-Ou Shu, Patrick M Sluss, Paul N Staats, Antonia Trichopoulou, Elisabete Weiderpass, Anne Zeleniuch-Jacquotte, Wei Zheng, Joanne F Dorgan
BACKGROUND: The Mullerian ducts are the embryological precursors of the female reproductive tract, including the uterus; anti-Mullerian hormone (AMH) has a key role in the regulation of foetal sexual differentiation. Anti-Mullerian hormone inhibits endometrial tumour growth in experimental models by stimulating apoptosis and cell cycle arrest. To date, there are no prospective epidemiologic data on circulating AMH and endometrial cancer risk. METHODS: We investigated this association among women premenopausal at blood collection in a multicohort study including participants from eight studies located in the United States, Europe, and China...
September 5, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28802830/gfap-in-early-multiple-sclerosis-a-biomarker-for-inflammation
#2
Rebecca Kassubek, Martin Gorges, Michael Schocke, Viktoria A M Hagenston, André Huss, Albert C Ludolph, Jan Kassubek, Hayrettin Tumani
OBJECTIVE: The role of Glial Fibrillic Acidic Protein (GFAP) as a potential biomarker for relapsing-remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) has been controversially discussed. The aim was to characterize the added value of GFAP levels in the CSF of RRMS and CIS patients in correlation with MRI lesion load. MATERIALS & METHODS: GFAP levels in the CSF from 18 patients with RRMS, 8 patients with CIS and 35 controls were analyzed together with MRI data for acute and chronic inflammatory lesion load...
August 9, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28797521/increasing-chloride-in-rivers-of-the-conterminous-u-s-and-linkages-to-potential-corrosivity-and-lead-action-level-exceedances-in-drinking-water
#3
E G Stets, C J Lee, D A Lytle, M R Schock
Corrosion in water-distribution systems is a costly problem and controlling corrosion is a primary focus of efforts to reduce lead (Pb) and copper (Cu) in tap water. High chloride concentrations can increase the tendency of water to cause corrosion in distribution systems. The effects of chloride are also expressed in several indices commonly used to describe the potential corrosivity of water, the chloride-sulfate mass ratio (CSMR) and the Larson Ratio (LR). Elevated CSMR has been linked to the galvanic corrosion of Pb whereas LR is indicative of the corrosivity of water to iron and steel...
August 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28754794/a-comparative-study-on-the-wcrf-international-university-of-bristol-methodology-for-systematic-reviews-of-mechanisms-underpinning-exposure-cancer-associations
#4
Gökhan Ertaylan, Charlotte Le Cornet, Eline H van Roekel, Audrey Y Jung, Martijn J L Bours, Antje Damms-Machado, Piet A van den Brandt, Helena Schock, Theo M de Kok, Jan Theys, Ilja C W Arts, Rudolf Kaaks, Matty P Weijenberg, Renée Turzanski Fortner
The World Cancer Research Fund International and the University of Bristol have developed a novel framework for providing an overview of mechanistic pathways and conducting a systematic literature review of the biologically plausible mechanisms underlying exposure-cancer associations. Two teams independently applied the two-stage framework on mechanisms underpinning the association between body fatness and breast cancer to test the framework feasibility and reproducibility as part of a WCRF-Commissioned validation study...
July 28, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28732005/filamin-actin-binding-and-titin-binding-fulfill-distinct-functions-in-z-disc-cohesion
#5
Nicanor González-Morales, Tristan K Holenka, Frieder Schöck
Many proteins contribute to the contractile properties of muscles, most notably myosin thick filaments, which are anchored at the M-line, and actin thin filaments, which are anchored at the Z-discs that border each sarcomere. In humans, mutations in the actin-binding protein Filamin-C result in myopathies, but the underlying molecular function is not well understood. Here we show using Drosophila indirect flight muscle that the filamin ortholog Cheerio in conjunction with the giant elastic protein titin plays a crucial role in keeping thin filaments stably anchored at the Z-disc...
July 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28724244/evaluating-mercury-concentrations-and-body-condition-in-american-alligators-alligator-mississippiensis-at-merritt-island-national-wildlife-refuge-minwr-florida
#6
Frances M Nilsen, Jonathan E Dorsey, Russell H Lowers, Louis J Guillette, Stephen E Long, John A Bowden, Tracey B Schock
Concentrations of mercury (Hg) are not well studied in free-ranging wildlife. Atmospheric deposition patterns of Hg have been studied in detail and have been modeled for both global and specific locations and often correlate to environmental impact. However, monitoring the impact of Hg deposition in wildlife is complicated due to local environmental conditions that can affect the transformation of atmospheric Hg to the biologically available forms (e.g., rainfall, humidity, pH, the ability of the environment to methylate Hg), as well as affect the accessibility to organisms for sampling...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28720108/early-pregnancy-sex-steroids-during-primiparous-pregnancies-and-maternal-breast-cancer-a-nested-case-control-study-in-the-northern-sweden-maternity-cohort
#7
Renée T Fortner, Eglé Tolockiene, Helena Schock, Husam Oda, Hans-Åke Lakso, Göran Hallmans, Rudolf Kaaks, Paolo Toniolo, Anne Zeleniuch-Jacquotte, Kjell Grankvist, Eva Lundin
BACKGROUND: Pregnancy and parity are associated with subsequent breast cancer risk. Experimental and epidemiologic data suggest a role for pregnancy sex steroid hormones. METHODS: We conducted a nested case-control study in the Northern Sweden Maternity Cohort (1975-2007). Eligible women had provided a blood sample in the first 20 weeks of gestation during a primiparous pregnancy leading to a term delivery. The current study includes 223 cases and 417 matched controls (matching factors: age at and date of blood collection)...
July 18, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28714593/free-water-improves-detection-of-changes-in-the-substantia-nigra-in-parkinsonism-a-multisite-study
#8
Edward Ofori, Florian Krismer, Roxana G Burciu, Ofer Pasternak, Johanna L McCracken, Mechelle M Lewis, Guangwei Du, Nikolaus R McFarland, Michael S Okun, Werner Poewe, Christoph Mueller, Elke R Gizewski, Michael Schocke, Christian Kremser, Hong Li, Xuemei Huang, Klaus Seppi, David E Vaillancourt
BACKGROUND: Imaging markers that are sensitive to parkinsonism across multiple sites are critically needed for clinical trials. The objective of this study was to evaluate changes in the substantia nigra using single- and bi-tensor models of diffusion magnetic resonance imaging in PD, MSA, and PSP. METHODS: The study cohort (n = 425) included 107 healthy controls and 184 PD, 63 MSA, and 71 PSP patients from 3 movement disorder centers. Bi-tensor free water, free-water-corrected fractional anisotropy, free-water-corrected mean diffusivity, single-tensor fractional anisotropy, and single-tensor mean diffusivity were computed for the anterior and posterior substantia nigra...
July 17, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28701332/circulating-rankl-and-rankl-opg-and-breast-cancer-risk-by-er-and-pr-subtype-results-from-the-epic-cohort
#9
Danja Sarink, Helena Schock, Theron Johnson, Kim Overvad, Marianne Holm, Anne Tjønneland, Marie-Christine Boutron-Ruault, Mathilde His, Marina Kvaskoff, Heiner Boeing, Pagona Lagiou, Eleni-Maria Papatesta, Antonia Trichopoulou, Domenico Palli, Valeria Pala, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, H B As Bueno-de-Mesquita, Carla H van Gils, Petra H Peeters, Elisabete Weiderpass, Antonio Agudo, Maria-José Sánchez, Maria-Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Kay Tee Khaw, Ruth Travis, Laure Dossus, Mark Gunter, Sabina Rinaldi, Melissa Merritt, Elio Riboli, Rudolf Kaaks, Renée T Fortner
Receptor activator of nuclear factor-kappa B (RANK)-RANK ligand (RANKL) signaling promotes mammary tumor development in experimental models. Circulating concentrations of soluble RANKL (sRANKL) may influence breast cancer risk via activation of RANK signaling; this may be modulated by osteoprotegerin (OPG), the decoy receptor for RANKL. sRANKL and breast cancer risk by hormone receptor subtype has not previously been investigated. A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort...
July 12, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28647536/crhr1-exacerbates-the-glial-inflammatory-response-and-alters-bdnf-trkb-pcreb-signaling-in-a-rat-model-of-global-cerebral-ischemia-implications-for-neuroprotection-and-cognitive-recovery
#10
Patricia B de la Tremblaye, Simon M Benoit, Sarah Schock, Hélène Plamondon
This study examined the impact of corticotropin-releasing hormone type 1 receptor (CRHR1) blockade using Antalarmin (ANT) on the expression of markers of neuroplasticity and inflammation, as well as neuroprotection and behavioral recovery following global cerebral ischemia. Male Wistar rats (N=50) were treated with ANT (2μg/2μl; icv) or a vehicle solution prior to a sham or four vessel (4VO) occlusion. Seven days post ischemia, anxiety was assessed in the Elevated Plus Maze and Open Field tests, and fear and spatial learning in a Y-Maze Passive Avoidance Task and the Barnes Maze...
June 21, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28631158/rapid-and-reliable-steroid-hormone-profiling-in-tursiops-truncatus-blubber-using-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms
#11
Ashley S P Boggs, Tracey B Schock, Lori H Schwacke, Thomas M Galligan, Jeanine S Morey, Wayne E McFee, John R Kucklick
Monitoring of marine mammal steroid hormone status using matrices alternative to blood is desirable due to the ability to remotely collect samples, which minimizes stress to the animal. However, measurement techniques in alternative matrices such as blubber described to date are limited in the number and types of hormones measured. Therefore, a new method using bead homogenization to QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) extraction, C18 post extraction cleanup and analysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) was developed and applied to the measurement of hormone suites in bottlenose dolphin blubber...
August 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28528429/myocardial-edema-in-acute-myocarditis-relationship-of-t2-relaxometry-and-late-enhancement-burden-by-using-dual-contrast-turbo-spin-echo-mri
#12
A Mayr, G Klug, H J Feistritzer, S J Reinstadler, M Reindl, R Esterhammer, G Feuchtner, B Metzler, M F Schocke
To quantify myocardial edema by using a T2 relaxometry approach with a dual-contrast turbo spin-echo (dcTSE) sequence in patients with acute myocarditis regarding focal late gadolinium enhancement (LGE) burden. CMR T2 relaxometry was performed in 39 patients (age 41 ± 19 years; 36% women) with LGE in a typical myocarditis pattern and in ten healthy volunteers (age 46 ± 12; 60% woman). dcTSE sequence (echo time 29 and 75 ms, respectively) was used for T2 mapping, analysis were performed on the basis of region of interest (ROI)...
May 20, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28489217/intra-aortic-balloon-pump-in-cardiogenic-shock-state-of-the-art
#13
Petronio Generoso Thomaz, Leonel Adelino Moura, Giovana Muramoto, Renato Samy Assad
The clinical definition of cardiogenic shock is that of a low cardiac output and evidence of tissue hypoxia in the presence of adequate blood volume. Cardiogenic shock is the main cause of death related to acute myocardial infarction (AMI), with a mortality rate of 45-70% in the absence of aggressive and highly specialized technical care. The intra-aortic balloon pump (IABP) is one of the most widely used mechanical assisting devices. During the last two decades, about 42% of patients with AMI who evolved with cardiogenic shock received mechanical circulatory assistance with IABP...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28456036/trace-element-biodistribution-in-the-american-alligator-alligator-mississippiensis
#14
Frances M Nilsen, Brittany L Kassim, J Patrick Delaney, Ted R Lange, Arnold M Brunell, Louis J Guillette, Stephen E Long, Tracey B Schock
Routine monitoring of contaminant levels in wildlife is important for understanding chemical exposure and ultimately the link to ecosystem and human health. This is particularly important when the monitored species is recreationally hunted for human consumption. In the southeastern United States, recreational alligator harvesting takes place annually and in locations that are known to be contaminated with environmental pollutants. In this study, we investigated the biodistribution of trace elements in the American alligator (Alligator mississippiensis) from five sites in Florida, USA...
August 2017: Chemosphere
https://www.readbyqxmd.com/read/28416053/-treatment-of-anaphylactic-schock-in-pregnant-women
#15
Therese Simonsen Straarup, Ulla Bang
This is an update on the treatment of anaphylactic shock in pregnant women. Most guidelines recommend adrenaline as first-line treatment in all patients, but in pregnant patients some recommend ephedrine due to a potential risk of utero-placental hypoperfusion with adrenaline. However, ephedrine is a less potent vasopressor than adrenaline and does not possess the same anti-inflammatory or broncho-dilating effects. As immediate and correct treatment is essential for both the maternal and the fetal outcome, adrenaline should be first-line treatment also in pregnant women...
April 10, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28390838/super-resolution-microscopy-approaches-to-nuclear-nanostructure-imaging
#16
Christoph Cremer, Aleksander Szczurek, Florian Schock, Amine Gourram, Udo Birk
The human genome has been decoded, but we are still far from understanding the regulation of all gene activities. A largely unexplained role in these regulatory mechanisms is played by the spatial organization of the genome in the cell nucleus which has far-reaching functional consequences for gene regulation. Until recently, it appeared to be impossible to study this problem on the nanoscale by light microscopy. However, novel developments in optical imaging technology have radically surpassed the limited resolution of conventional far-field fluorescence microscopy (ca...
July 1, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28381542/androgens-are-differentially-associated-with-ovarian-cancer-subtypes-in-the-ovarian-cancer-cohort-consortium
#17
Jennifer Ose, Elizabeth M Poole, Helena Schock, Matti Lehtinen, Alan A Arslan, Anne Zeleniuch-Jacquotte, Kala Visvanathan, Kathy Helzlsouer, Julie E Buring, I-Min Lee, Anne Tjønneland, Laure Dossus, Antonia Trichopoulou, Giovanna Masala, N Charlotte Onland-Moret, Elisabete Weiderpass, Eric J Duell, Annika Idahl, Ruth C Travis, Sabina Rinaldi, Melissa A Merritt, Britton Trabert, Nicolas Wentzensen, Shelley S Tworoger, Rudolf Kaaks, Renée T Fortner
Invasive epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. The etiology of EOC remains elusive; however, experimental and epidemiologic data suggest a role for hormone-related exposures in ovarian carcinogenesis and risk factor differences by histologic phenotypes and developmental pathways. Research on prediagnosis androgen concentrations and EOC risk has yielded inconclusive results, and analyses incorporating EOC subtypes are sparse. We conducted a pooled analysis of 7 nested case-control studies in the Ovarian Cancer Cohort Consortium to investigate the association between pre-diagnosis circulating androgens [testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS)], sex hormone binding globulin (SHBG), and EOC risk by tumor characteristics (i...
July 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28381034/dual-energy-micro-ct-with-a-dual-layer-dual-color-single-crystal-scintillator
#18
Daniel Simon Maier, Jonathan Schock, Franz Pfeiffer
A wide range of X-ray imaging applications demand micrometer spatial resolution. In material science and biology especially, there is a great interest in material determination and material separation methods. Here we present a new detector design that allows the recording of a low- and a high-energy radiography image simultaneously with micrometer spatial resolution. The detector system is composed of a layered scintillator stack, two CCDs and an optical system to image the scintillator responses onto the CCDs...
March 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28366409/demographic-lifestyle-and-other-factors-in-relation-to-antim%C3%A3-llerian-hormone-levels-in-mostly-late-premenopausal-women
#19
MULTICENTER STUDY
Seungyoun Jung, Naomi Allen, Alan A Arslan, Laura Baglietto, Louise A Brinton, Brian L Egleston, Roni Falk, Renée T Fortner, Kathy J Helzlsouer, Annika Idahl, Rudolph Kaaks, Eva Lundin, Melissa Merritt, Charlotte Onland-Moret, Sabina Rinaldi, María-José Sánchez, Sabina Sieri, Helena Schock, Xiao-Ou Shu, Patrick M Sluss, Paul N Staats, Ruth C Travis, Anne Tjønneland, Antonia Trichopoulou, Shelley Tworoger, Kala Visvanathan, Vittorio Krogh, Elisabete Weiderpass, Anne Zeleniuch-Jacquotte, Wei Zheng, Joanne F Dorgan
OBJECTIVE: To identify reproductive, lifestyle, hormonal, and other correlates of circulating antimüllerian hormone (AMH) concentrations in mostly late premenopausal women. DESIGN: Cross-sectional study. SETTING: Not applicable. PATIENT(S): A total of 671 premenopausal women not known to have cancer. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Concentrations of AMH were measured in a single laboratory using the picoAMH ELISA...
April 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28346501/a-tissue-specific-role-for-intraflagellar-transport-genes-during-craniofacial-development
#20
Elizabeth N Schock, Jaime N Struve, Ching-Fang Chang, Trevor J Williams, John Snedeker, Aria C Attia, Rolf W Stottmann, Samantha A Brugmann
Primary cilia are nearly ubiquitous, cellular projections that function to transduce molecular signals during development. Loss of functional primary cilia has a particularly profound effect on the developing craniofacial complex, causing several anomalies including craniosynostosis, micrognathia, midfacial dysplasia, cleft lip/palate and oral/dental defects. Development of the craniofacial complex is an intricate process that requires interactions between several different tissues including neural crest cells, neuroectoderm and surface ectoderm...
2017: PloS One
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