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https://www.readbyqxmd.com/read/28213462/discovery-diagnosis-and-etiology-of-craniofacial-ciliopathies
#1
Elizabeth N Schock, Samantha A Brugmann
Seventy-five percent of congenital disorders present with some form of craniofacial malformation. The frequency and severity of these malformations makes understanding the etiological basis crucial for diagnosis and treatment. A significant link between craniofacial malformations and primary cilia arose several years ago with the determination that ∼30% of ciliopathies could be primarily defined by their craniofacial phenotype. The link between the cilium and the face has proven significant, as several new "craniofacial ciliopathies" have recently been diagnosed...
February 17, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28205047/pre-diagnosis-insulin-like-growth-factor-i-and-risk-of-epithelial-invasive-ovarian-cancer-by-histological-subtypes-a-collaborative-re-analysis-from-the-ovarian-cancer-cohort-consortium
#2
Jennifer Ose, Helena Schock, Elizabeth M Poole, Matti Lehtinen, Kala Visvanathan, Kathy Helzlsouer, Julie E Buring, I-Min Lee, Anne Tjønneland, Marie-Christine Boutron-Ruault, Antonia Trichopoulou, Amalia Mattiello, N Charlotte Onland-Moret, Elisabete Weiderpass, María-José Sánchez, Annika Idahl, Ruth C Travis, Sabina Rinaldi, Melissa A Merritt, Nicolas Wentzensen, Shelley S Tworoger, Rudolf Kaaks, Renée T Fortner
PURPOSE: Biologic evidence suggests that the Insulin-like growth factor (IGF)-family may be involved in the etiology of epithelial invasive ovarian cancer (EOC). However, prospective studies investigating the role of IGF-I in ovarian carcinogenesis have yielded conflicting results. METHODS: We pooled and harmonized data from 6 case-control studies nested within the Ovarian Cancer Cohort Consortium to investigate the association between pre-diagnosis IGF-I concentrations and subsequent risk of EOC...
February 16, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28188319/clinical-inquiry-do-pedometers-increase-activity-and-improve-health-outcomes
#3
Devin Schock, Jon O Neher, Sarah Safranek
In overweight and obese patients, exercise interventions using a pedometer increase steps by about a mile per day over the same interventions without access to pedometer information and are associated with a modest 4 mm Hg reduction in systolic blood pressure (BP) over baseline. In overweight patients with diabetes, pedometer use with nutritional counseling is associated with 0.86 kg greater weight loss than nutritional counseling alone.
January 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28173834/osteoprotegerin-and-breast-cancer-risk-by-hormone-receptor-subtype-a-nested-case-control-study-in-the-epic-cohort
#4
Renée T Fortner, Danja Sarink, Helena Schock, Theron Johnson, Anne Tjønneland, Anja Olsen, Kim Overvad, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Heiner Boeing, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Domenico Palli, Sabina Sieri, Amalia Mattiello, Rosario Tumino, Fulvio Ricceri, H Bas Bueno-de-Mesquita, Petra H M Peeters, Carla H Van Gils, Elisabete Weiderpass, Eiliv Lund, J Ramón Quirós, Antonio Agudo, Maria-José Sánchez, María-Dolores Chirlaque, Eva Ardanaz, Miren Dorronsoro, Tim Key, Kay-Tee Khaw, Sabina Rinaldi, Laure Dossus, Marc Gunter, Melissa A Merritt, Elio Riboli, Rudolf Kaaks
BACKGROUND: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study. METHODS: A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort...
February 8, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28060376/induction-of-necroptotic-cell-death-by-viral-activation-of-the-rig-i-or-sting-pathway
#5
Suruchi N Schock, Neha V Chandra, Yuefang Sun, Takashi Irie, Yoshinori Kitagawa, Bin Gotoh, Laurent Coscoy, Astar Winoto
Necroptosis is a form of necrotic cell death that requires the activity of the death domain-containing kinase RIP1 and its family member RIP3. Necroptosis occurs when RIP1 is deubiquitinated to form a complex with RIP3 in cells deficient in the death receptor adapter molecule FADD or caspase-8. Necroptosis may play a role in host defense during viral infection as viruses like vaccinia can induce necroptosis while murine cytomegalovirus encodes a viral inhibitor of necroptosis. To see how general the interplay between viruses and necroptosis is, we surveyed seven different viruses...
January 6, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28059405/mixing-behaviour-of-wpi-pectin-complexes-in-meat-dispersions-impact-of-biopolymer-ratios
#6
Benjamin Zeeb, Vanessa Schöck, Nicole Schmid, Lisa Majer, Kurt Herrmann, Jörg Hinrichs, Jochen Weiss
Particulated complexes composed of oppositely charged biopolymers were incorporated into highly concentrated protein matrices as potential fat replacers and structuring agents. A multistep procedure was therefore utilized to generate process-stable complexes, which were subsequently embedded into emulsion-type sausages, whereas macro- and microstructural properties were then assessed. Firstly, stock WPI and sugar beet pectin solutions were mixed under neutral conditions (pH 7) at various biopolymer ratios r (2 : 1, 5 : 1, 8 : 1)...
January 6, 2017: Food & Function
https://www.readbyqxmd.com/read/27906641/time-to-cooling-is-associated-with-resuscitation-outcomes
#7
Robert B Schock, Andreas Janata, W Frank Peacock, Nathan S Deal, Sarathi Kalra, Fritz Sterz
Our purpose was to analyze evidence related to timing of cooling from studies of targeted temperature management (TTM) after return of spontaneous circulation (ROSC) after cardiac arrest and to recommend directions for future therapy optimization. We conducted a preliminary review of studies of both animals and patients treated with post-ROSC TTM and hypothesized that a more rapid cooling strategy in the absence of volume-adding cold infusions would provide improved outcomes in comparison with slower cooling...
December 2016: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27883139/clustered-localization-of-egfrviii-in-glioblastoma-cells-as-detected-by-high-precision-localization-microscopy
#8
Philip S Boyd, Nina Struve, Margund Bach, Jan Philipp Eberle, Martin Gote, Florian Schock, Christoph Cremer, Malte Kriegs, Michael Hausmann
For receptor tyrosine kinases supramolecular organization on the cell membrane is critical for their function. Super-resolution fluorescence microscopy techniques have offered new opportunities for the analysis of single receptor localization. Here, we analysed the cluster formation of the epidermal growth factor receptor variant III (EGFRvIII), a deletion variant which is expressed in glioblastoma. The constitutively activated variant EGFRvIII is expressed in cells with an egfr gene amplification and is thought to enhance the tumorigenic potential especially of glioblastoma cells...
December 28, 2016: Nanoscale
https://www.readbyqxmd.com/read/27848981/listeria-monocytogenes-sequence-type-1-is-predominant-in-ruminant-rhombencephalitis
#9
Margaux Dreyer, Lisandra Aguilar-Bultet, Sebastian Rupp, Claudia Guldimann, Roger Stephan, Alexandra Schock, Arthur Otter, Gertraud Schüpbach, Sylvain Brisse, Marc Lecuit, Joachim Frey, Anna Oevermann
Listeria (L.) monocytogenes is an opportunistic pathogen causing life-threatening infections in diverse mammalian species including humans and ruminants. As little is known on the link between strains and clinicopathological phenotypes, we studied potential strain-associated virulence and organ tropism in L. monocytogenes isolates from well-defined ruminant cases of clinical infections and the farm environment. The phylogeny of isolates and their virulence-associated genes were analyzed by multilocus sequence typing (MLST) and sequence analysis of virulence-associated genes...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27834172/impact-of-new-traumatic-or-stressful-life-events-on-pre-existing-ptsd-in-traumatized-refugees-results-of-a-longitudinal-study
#10
Katrin Schock, Maria Böttche, Rita Rosner, Mechthild Wenk-Ansohn, Christine Knaevelsrud
BACKGROUND: A significant proportion of trauma survivors experience an additional critical life event in the aftermath. These renewed experiences of traumatic and stressful life events may lead to an increase in trauma-related mental health symptoms. METHOD: In a longitudinal study, the effects of renewed experiences of a trauma or stressful life event were examined. For this purpose, refugees seeking asylum in Germany were assessed for posttraumatic stress symptoms (PTS), Posttraumatic Stress Diagnostic Scale (PDS), anxiety, and depression (Hopkins Symptom Checklist [HSCL-25]) before treatment start as well as after 6 and 12 months during treatment (N=46)...
2016: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/27799912/understanding-mechanisms-of-gli-mediated-transcription-during-craniofacial-development-and-disease-using-the-ciliopathic-mutant-talpid-2
#11
Ya-Ting Chang, Praneet Chaturvedi, Elizabeth N Schock, Samantha A Brugmann
The primary cilium is a ubiquitous, microtubule-based organelle that cells utilize to transduce molecular signals. Ciliopathies are a group of diseases that are caused by a disruption in the structure or function of the primary cilium. Over 30% of all ciliopathies are primarily defined by their craniofacial phenotypes, which typically include midfacial defects, cleft lip/palate, micrognathia, aglossia, and craniosynostosis. The frequency and severity of craniofacial phenotypes in ciliopathies emphasizes the importance of the cilium during development of the craniofacial complex...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27789739/plant-specific-preprotein-and-amino-acid-transporter-proteins-are-required-for-trna-import-into-mitochondria
#12
Monika W Murcha, Szymon Kubiszewski-Jakubiak, Pedro F Teixeira, Irene L Gügel, Beata Kmiec, Reena Narsai, Aneta Ivanova, Cyrille Megel, Annette Schock, Sabrina Kraus, Oliver Berkowitz, Elzbieta Glaser, Katrin Philippar, Laurence Maréchal-Drouard, Jürgen Soll, James Whelan
A variety of eukaryotes, in particular plants, do not contain the required number of tRNAs to support the translation of mitochondria-encoded genes and thus need to import tRNAs from the cytosol. This study identified two Arabidopsis (Arabidopsis thaliana) proteins, Tric1 and Tric2 (for tRNA import component), which on simultaneous inactivation by T-DNA insertion lines displayed a severely delayed and chlorotic growth phenotype and significantly reduced tRNA import capacity into isolated mitochondria. The predicted tRNA-binding domain of Tric1 and Tric2, a sterile-α-motif at the C-terminal end of the protein, was required to restore tRNA uptake ability in mitochondria of complemented plants...
December 2016: Plant Physiology
https://www.readbyqxmd.com/read/27784743/human-chorionic-gonadotropin-does-not-correlate-with-risk-for-maternal-breast-cancer-results-from-the-finnish-maternity-cohort
#13
Renée T Fortner, Helena Schock, Rudolf Kaaks, Matti Lehtinen, Eero Pukkala, Hans-Åke Lakso, Minna Tanner, Raija Kallio, Heikki Joensuu, Jaana Korpela, Adetunji T Toriola, Göran Hallmans, Kjell Grankvist, Anne Zeleniuch-Jacquotte, Paolo Toniolo, Eva Lundin, Heljä-Marja Surcel
Human chorionic gonadotropin (hCG) is necessary for the maintenance of early pregnancy and promotes normal breast cell differentiation. Administered hCG reduces risk of carcinogen-induced breast cancer in animal models, and higher circulating hCG concentrations were associated with significantly lower long-term risk of breast cancer in a prior nested case-control study. In this study, we investigated early-pregnancy hCG concentrations and subsequent breast cancer risk. We conducted a nested case-control study with 1,191 cases and 2,257 controls (matched on age and date at blood collection) in the Finnish Maternity Cohort, a cohort with serum samples from 98% of pregnancies registered in Finland since 1983...
January 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/27783625/zasp52-a-core-z-disc-protein-in-drosophila-indirect-flight-muscles-interacts-with-%C3%AE-actinin-via-an-extended-pdz-domain
#14
Kuo An Liao, Nicanor González-Morales, Frieder Schöck
Z-discs are organizing centers that establish and maintain myofibril structure and function. Important Z-disc proteins are α-actinin, which cross-links actin thin filaments at the Z-disc and Zasp PDZ domain proteins, which directly interact with α-actinin. Here we investigate the biochemical and genetic nature of this interaction in more detail. Zasp52 is the major Drosophila Zasp PDZ domain protein, and is required for myofibril assembly and maintenance. We show by in vitro biochemistry that the PDZ domain plus a C-terminal extension is the only area of Zasp52 involved in the interaction with α-actinin...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27752513/longitudinal-profile-of-iron-accumulation-in-good-grade-subarachnoid-hemorrhage
#15
Christoph Scherfler, Alois Josef Schiefecker, Margarete Delazer, Ronny Beer, Thomas Bodner, Georg Spinka, Mario Kofler, Bettina Pfausler, Christian Kremser, Michael Schocke, Thomas Benke, Elke R Gizewski, Erich Schmutzhard, Raimund Helbok
OBJECTIVE: MRI parameters of iron concentration (R2*, transverse relaxation rate), microstructural integrity (mean diffusivity and fractional anisotropy), as well as gray and white matter volumes were analyzed in patients with subarachnoid hemorrhage (SAH) and uncomplicated clinical course to detect the evolution of brain tissue changes 3 weeks and 12 months after ictus. METHODS: MRI scans of 14 SAH patients (aneurysm of the anterior communicating artery, n = 5; no aneurysm n = 9) were compared with 14 age-matched healthy control subjects...
October 2016: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/27665115/improved-kinetic-model-for-the-transcutaneous-measurement-of-glomerular-filtration-rate-in-experimental-animals
#16
Jochen Friedemann, Ralf Heinrich, Yury Shulhevich, Matthias Raedle, Lena William-Olsson, Johannes Pill, Daniel Schock-Kusch
Transcutaneous measurement of the glomerular filtration rate (tGFR) is now frequently used in animal studies. tGFR allows consecutive measurements on the same animal, including multiple measurements on a daily basis, because no blood sampling is required. Here we derive and validate a novel kinetic model for the description of transcutaneously measured FITC-Sinistrin excretion kinetics. In contrast to standard 1- to 3-compartment models, our model covers the complete kinetic, including injection and distribution of the tracer in the plasma compartment...
September 21, 2016: Kidney International
https://www.readbyqxmd.com/read/27625969/comparison-of-preoperative-mri-and-intraoperative-findings-of-posterior-tibial-tendon-insufficiency
#17
Matthias Braito, Martina Wöß, Benjamin Henninger, Michael Schocke, Michael Liebensteiner, Dennis Huber, Martin Krismer, Rainer Biedermann
BACKGROUND: The purpose of this study was to investigate the radiological and surgical correlation between preoperative magnetic resonance images (MRI) and the intraoperative findings in patients with acquired adult flatfoot. RESULTS: The overall radiological-surgical correlation between preoperative MRI and the intraoperative findings for posterior tibial tendon insufficiency was only slight to fair in our patient's series. Comparing the most commonly used posterior tibial tendon classification systems, the classification of Rosenberg et al...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27605601/daily-stress-hearing-specific-stress-and-coping-self-reports-from-deaf-or-hard-of-hearing-children-and-children-with-auditory-processing-disorder
#18
Heike Eschenbeck, Vera Gillé, Uwe Heim-Dreger, Alexandra Schock, Andrea Schott
This study evaluated stressors and coping strategies in 70 children who are deaf or hard of hearing (D/HH) or with auditory processing disorder (APD) attending Grades 5 and 6 of a school for deaf and hard-of-hearing children. Everyday general stressors and more hearing-specific stressors were examined in a hearing-specific modified stress and coping questionnaire. Reports were compared with normative data for hearing children. Regarding everyday general stressors, stress levels for children who are D/HH or with APD did not differ from those of hearing children...
January 2017: Journal of Deaf Studies and Deaf Education
https://www.readbyqxmd.com/read/27498336/activation-of-crhr1-receptors-regulates-social-and-depressive-like-behaviors-and-expression-of-bdnf-and-trkb-in-mesocorticolimbic-regions-following-global-cerebral-ischemia
#19
Patricia Barra de la Tremblaye, Nicolas Narvaez Linares, Sarah Schock, Hélène Plamondon
Increased HPA axis activation and CRH release characterize the brain's response to global cerebral ischemia. Recently, CRH via activation of CRH type 1 receptors (CRHR1) has been shown to regulate Brain Derived Neurotrophic Factor (BDNF) secretion and emotional behavior. The current study investigates the impact of CRHR1 blockade on BDNF/TrkB signaling expression in the mesolimbic circuitry, and social and depressive-like behavior following global ischemia. Adult male Wistar rats were injected with Antalarmin (2μg/μl) or a vehicle 30min prior to 10min global cerebral ischemia (4VO model) or sham occlusion...
August 3, 2016: Experimental Neurology
https://www.readbyqxmd.com/read/27440167/radiographic-improvement-of-hepatic-steatosis-after-laparoscopic-roux-en-y-gastric-bypass
#20
Joshua S Winder, Brandon S Dudeck, Sarayna Schock, Jerome R Lyn-Sue, Randy S Haluck, Ann M Rogers
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease and the leading cause of cirrhosis in developed nations. Studies confirm improvement of liver histopathology after significant weight loss, but biochemistry and sonography do not always show this. Computed tomographic (CT) findings of NAFLD include low attenuation of liver parenchyma and hepatomegaly. We hypothesized that patients experiencing significant weight loss after laparoscopic Roux-en-Y gastric bypass (LRYGB) would show CT improvement of NAFLD...
July 20, 2016: Obesity Surgery
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