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https://www.readbyqxmd.com/read/29643007/the-diagnostic-accuracy-of-the-hummingbird-and-morning-glory-sign-in-patients-with-neurodegenerative-parkinsonism
#1
Christoph Mueller, Anna Hussl, Florian Krismer, Beatrice Heim, Philipp Mahlknecht, Michael Nocker, Christoph Scherfler, Katherina Mair, Regina Esterhammer, Michael Schocke, Gregor K Wenning, Werner Poewe, Klaus Seppi
INTRODUCTION: The hummingbird sign and the morning glory flower sign, reflecting midbrain pathology on MRI, have previously been shown to separate patients with progressive supranuclear palsy (PSP) from those with Parkinson's disease (PD) and multiple system atrophy (MSA). The aim of the present study was to determine the diagnostic accuracy and reproducibility of visual assessment of midbrain atrophy patterns in a large cohort of patients with neurodegenerative parkinsonism. METHODS: Retrospective analysis of midbrain atrophy patterns on T1-weighted MRI in a large cohort of patients with neurodegenerative parkinsonism and healthy controls who underwent MR imaging during their diagnostic work-up...
April 3, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29616370/first-evaluation-of-alkylpyrazine-application-as-a-novel-method-to-decrease-microbial-contaminations-in-processed-meat-products
#2
Matthias Schöck, Stefan Liebminger, Gabriele Berg, Tomislav Cernava
Every year about 20% of the globally produced meat gets lost due to microbial spoilage. Nevertheless, the demand for processed meat is constantly rising and producers are searching for novel strategies to reduce microbial contaminations in their products. In the present study, we evaluated the applicability of alkylpyrazines as antimicrobial agents. These fragrant molecules naturally occur in different vegetables, fruits, roasted nut and meat. Several pyrazine derivatives are readily added to processed products for flavoring purposes in the food industry...
April 3, 2018: AMB Express
https://www.readbyqxmd.com/read/29570577/lower-extremity-horizontal-single-leg-hop-distance-but-not-vertical-power-predicts-lower-extremity-injury-in-female-collegiate-dancers
#3
Jatin P Ambegaonkar, Catherine Schock, Shane V Caswell, Nelson Cortes, Jena Hansen-Honeycutt, Matthew A Wyon
Dancers often perform powerful and explosive movements that require adequate lower extremity(LE) activity in horizontal and vertical directions. We examined if these measures were interrelated and whether they predicted LE injury status in dancers using binary logistic regressions and Receiver Operator Characteristic(ROC) curve analyses. Forty-three collegiate female dancers(18+0.7yrs; 162.6+5.9cm; 59.4+7.1kg) performed Single Leg Hop(SLH,m), and Vertical Jump(VJ,cm) tests. SLH and VJ distances were used to calculate SLH_norm (as a % of body height) and Vertical Power(vPower,watts)...
March 22, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29507073/topical-treatment-for-cutaneous-leishmaniasis-dermato-pharmacokinetic-lead-optimization-of-benzoxaboroles
#4
Katrien Van Bocxlaer, Eric Gaukel, Deirdre Hauser, Seong Hee Park, Sara Schock, Vanessa Yardley, Ryan Randolph, Jacob J Plattner, Tejal Merchant, Simon L Croft, Robert T Jacobs, Stephen A Wring
Cutaneous leishmaniasis (CL) is caused by several species of the protozoan parasite Leishmania , affecting an estimated 10 million people worldwide. Previously reported strategies for the development of topical CL treatments have focused primarily on drug permeation and formulation optimization as the means to increase treatment efficacy. Our approach aims to identify compounds with antileishmanial activity and properties consistent with topical administration. Of the test compounds, five benzoxaboroles showed potent activity (50% effective concentration [EC50 ] < 5 μM) against intracellular amastigotes of at least one Leishmania species and acceptable activity (20 μM < EC50 < 30 μM) against two more species...
May 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29469137/impact-of-food-structure-on-the-compatibility-of-heated-wpi-pectin-complexes-in-meat-dispersions
#5
Benjamin Zeeb, Vanessa Schöck, Nicole Schmid, Lisa Majer, Kurt Herrmann, Jörg Hinrichs, Jochen Weiss
Process-stable complexes composed of whey protein isolate (WPI) and sugar beet pectin have great potential as structuring agents or fat replacers in foods. The current study investigates the compatibility of heated WPI : pectin complexes in different meat matrices. Spreadable raw-fermented sausages and sliceable emulsion-type sausages were therefore manufactured containing biopolymer complexes with various WPI : pectin ratios r (2 : 1, 8 : 1). Macro- and microstructural properties of the meat dispersions were analyzed in terms of colour, texture, rheometry, sensory, and confocal laser scanning microscopy (CLSM) measurements...
March 1, 2018: Food & Function
https://www.readbyqxmd.com/read/29451398/examining-heat-treatment-for-stabilization-of-the-lipidome
#6
Jeremy P Koelmel, Christina M Jones, Candice Z Ulmer, Timothy J Garrett, Richard A Yost, Tracey B Schock, John A Bowden
AIM: To confidently determine lipid-based biomarkers, it is important to minimize variation introduced during preanalytical steps. We evaluated reducing variation associated with lipid measurements in invertebrate sentinel species using a state-of-the-art heat treatment technique. MATERIALS AND METHODS: Earthworms (Eisenia fetida), house crickets (Acheta domestica) and ghost shrimp (Palaemonetes paludosus) were euthanized either by flash freezing or heat treatment...
March 1, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29449186/the-reorganization-of-functional-architecture-in-the-early-stages-of-parkinson-s-disease
#7
Noora Tuovinen, Klaus Seppi, Francesco de Pasquale, Christoph Müller, Michael Nocker, Michael Schocke, Elke R Gizewski, Christian Kremser, Gregor K Wenning, Werner Poewe, Atbin Djamshidian, Christoph Scherfler, Morinobu Seki
INTRODUCTION: The study aim was to identify longitudinal abnormalities of functional connectivity and its relation with motor disability in early to moderately advanced stages of Parkinson's disease patients. METHODS: 3.0T structural and resting-state functional MRI was performed in healthy subjects (n = 16) and Parkinson's disease patients (n = 16) with mean disease duration of 2.2 ± 1.2 years at baseline with a clinical follow-up of 1.5 ± 0...
February 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29446300/mineralogical-evidence-of-galvanic-corrosion-in-drinking-water-lead-pipe-joints
#8
Michael K DeSantis, Simoni Triantafyllidou, Michael R Schock, Darren A Lytle
Galvanic corrosion as a mechanism of toxic lead release into drinking water has been under scientific debate in the U.S. for over 30 years. Visual and mineralogical analysis of 28 lead pipe joints, excavated after 60+ years from eight U.S. water utilities, provided the first direct view of three distinct galvanic corrosion patterns in practice: (1) no evidence of galvanic corrosion; (2) galvanic corrosion with lead cathode; (3) galvanic corrosion with lead anode. Pattern 3 is consistent with empirical galvanic series (lead → brass → copper in order of increasing nobility) and poses the greatest risk of Pb exposure...
March 20, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29423427/rapid-ifm-dissection-for-visualizing-fluorescently-tagged-sarcomeric-proteins
#9
Yu Shu Xiao, Frieder Schöck, Nicanor González-Morales
Sarcomeres, the smallest contractile unit of muscles, are arguably the most impressive actomyosin structure. Yet a complete understanding of sarcomere formation and maintenance is missing. The Drosophila indirect flight muscle (IFM) has proven to be a very valuable model to study sarcomeres. Here, we present a protocol for the rapid dissection of IFM and analysis of sarcomeres using fluorescently tagged proteins.
November 20, 2017: Bio-protocol
https://www.readbyqxmd.com/read/29163866/multidisciplinary-treatment-for-traumatized-refugees-in-a-naturalistic-setting-symptom-courses-and-predictors
#10
Nadine Stammel, Christine Knaevelsrud, Katrin Schock, Lena C S Walther, Mechthild Wenk-Ansohn, Maria Böttche
Background : Multidisciplinary treatment approaches are commonly used in specialized psychosocial centres for the treatment of traumatized refugees, but empirical evidence for their efficacy is inconsistent. Objective : In order to obtain more evidence on the development of mental health and well-being of traumatized refugees who receive multidisciplinary treatment, symptom courses of posttraumatic stress disorder (PTSD), anxiety, depression and somatoform symptoms as well as in the subjective quality of life were investigated in the course of a multidisciplinary treatment...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29159934/ovarian-cancer-early-detection-by-circulating-ca125-in-the-context-of-anti-ca125-autoantibody-levels-results-from-the-epic-cohort
#11
Renée T Fortner, Helena Schock, Charlotte Le Cornet, Anika Hüsing, Allison F Vitonis, Theron S Johnson, Raina N Fichorova, Titilayo Fashemi, Hidemi S Yamamoto, Anne Tjønneland, Louise Hansen, Kim Overvad, Marie-Christine Boutron-Ruault, Marina Kvaskoff, Gianluca Severi, Heiner Boeing, Antonia Trichopoulou, Eleni-Maria Papatesta, Carlo La Vecchia, Domenico Palli, Sabina Sieri, Rosario Tumino, Carlotta Sacerdote, Amalia Mattiello, N Charlotte Onland-Moret, Petra H Peeters, H B As Bueno-de-Mesquita, Elisabete Weiderpass, J Ramón Quirós, Eric J Duell, Maria-Jose Sánchez, Carmen Navarro, Eva Ardanaz, Nerea Larrañaga, Björn Nodin, Karin Jirström, Annika Idahl, Eva Lundin, Kay-Tee Khaw, Ruth C Travis, Marc Gunter, Mattias Johansson, Laure Dossus, Melissa A Merritt, Elio Riboli, Kathryn L Terry, Daniel W Cramer, Rudolf Kaaks
CA125 is the best ovarian cancer early detection marker to date; however, sensitivity is limited and complementary markers are required to improve discrimination between ovarian cancer cases and non-cases. Anti-CA125 autoantibodies are observed in circulation. Our objective was to evaluate whether these antibodies (1) can serve as early detection markers, providing evidence of an immune response to a developing tumor, and (2) modify the discriminatory capacity of CA125 by either masking CA125 levels (resulting in lower discrimination) or acting synergistically to improve discrimination between cases and non-cases...
April 1, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29126761/mr-planimetry-in-neurodegenerative-parkinsonism-yields-high-diagnostic-accuracy-for-psp
#12
Stephanie Mangesius, Anna Hussl, Florian Krismer, Philipp Mahlknecht, Eva Reiter, Susanne Tagwercher, Atbin Djamshidian, Michael Schocke, Regina Esterhammer, Gregor Wenning, Christoph Müller, Christoph Scherfler, Elke R Gizewski, Werner Poewe, Klaus Seppi
INTRODUCTION: Several previous studies examined different brainstem-derived MR planimetric measures with regards to their diagnostic accuracy in separating patients with neurodegenerative parkinsonian disorders and reported conflicting results. The current study aimed to compare their performance in a well-characterized sample of patients with neurodegenerative parkinsonian disorders. METHODS: MR planimetric measurements were assessed in a large retrospective cohort of 55 progressive supranuclear palsy (PSP), 194 Parkinson's disease (PD) and 63 multiple system atrophy (MSA) patients...
January 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29100965/transcutaneous-glomerular-filtration-rate-measurement-in-a-canine-animal-model-of-chronic-kidney-disease
#13
Thomas Mondritzki, Sarah M L Steinbach, Philip Boehme, Jessica Hoffmann, Maximilian Kullmann, Daniel Schock-Kusch, Julia Vogel, Peter Kolkhof, Peter Sandner, Erwin Bischoff, Jörg Hüser, Wilfried Dinh, Hubert Truebel
INTRODUCTION: Quantitative assessment of renal function by measurement of glomerular filtration rate (GFR) is an important part of safety and efficacy evaluation in preclinical drug development. Existing methods are often time consuming, imprecise and associated with animal burden. Here we describe the comparison between GFR determinations with sinistrin (PS-GFR) and fluorescence-labelled sinistrin-application and its transcutaneous detection (TD-GFR) in a large animal model of chronic kidney disease (CKD)...
March 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28941984/neural-crest-cells-utilize-primary-cilia-to-regulate-ventral-forebrain-morphogenesis-via-hedgehog-dependent-regulation-of-oriented-cell-division
#14
Elizabeth N Schock, Samantha A Brugmann
Development of the brain directly influences the development of the face via both physical growth and Sonic hedgehog (SHH) activity; however, little is known about how neural crest cells (NCCs), the mesenchymal population that comprise the developing facial prominences, influence the development of the brain. We utilized the conditional ciliary mutant Wnt1-Cre;Kif3a(fl/fl) to demonstrate that loss of primary cilia on NCCs resulted in a widened ventral forebrain. We found that neuroectodermal Shh expression, dorsal/ventral patterning, and amount of proliferation in the ventral neuroectoderm was not changed in Wnt1-Cre;Kif3a(fl/fl) mutants; however, tissue polarity and directional cell division were disrupted...
November 15, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28921520/anti-m%C3%A3-llerian-hormone-and-risk-of-ovarian-cancer-in-nine-cohorts
#15
Seungyoun Jung, Naomi Allen, Alan A Arslan, Laura Baglietto, Aurelio Barricarte, Louise A Brinton, Brian L Egleston, Roni T Falk, Renée T Fortner, Kathy J Helzlsouer, Yutang Gao, Annika Idahl, Rudolph Kaaks, Vittorio Krogh, Melissa A Merritt, Eva Lundin, N Charlotte Onland-Moret, Sabina Rinaldi, Helena Schock, Xiao-Ou Shu, Patrick M Sluss, Paul N Staats, Carlotta Sacerdote, Ruth C Travis, Anne Tjønneland, Antonia Trichopoulou, Shelley S Tworoger, Kala Visvanathan, Elisabete Weiderpass, Anne Zeleniuch-Jacquotte, Joanne F Dorgan
Animal and experimental data suggest that anti-Müllerian hormone (AMH) serves as a marker of ovarian reserve and inhibits the growth of ovarian tumors. However, few epidemiologic studies have examined the association between AMH and ovarian cancer risk. We conducted a nested case-control study of 302 ovarian cancer cases and 336 matched controls from nine cohorts. Prediagnostic blood samples of premenopausal women were assayed for AMH using a picoAMH enzyme-linked immunosorbent assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable-adjusted conditional logistic regression...
January 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28920482/fowl-aviadenovirus-serotype-1-confirmed-as-the-aetiological-agent-of-gizzard-erosions-in-replacement-pullets-and-layer-flocks-in-great-britain-by-laboratory-and-in-vivo-studies
#16
Beatrice Grafl, Cristina Garcia-Rueda, Peter Cargill, Alisdair Wood, Alex Schock, Dieter Liebhart, Anna Schachner, Michael Hess
An investigation into the aetiology and pathogenesis of adenoviral gizzard erosion has been conducted following three natural outbreaks affecting one flock of 6-week-old replacement pullets and two consecutive placements of free range layers at the age of 21 and 23 weeks. Affected flocks showed increased mortality (0.12-0.30% per week), and gizzard lesions were consistent with fowl aviadenovirus (FAdV) involvement. To substantiate the initial findings, a selection of archived formalin-fixed paraffin-embedded gizzard samples from another 12 pullet and layer flocks, for which macroscopic and histopathological diagnosis of the disease were recorded in Great Britain during the period 2009-2016, were also investigated...
February 2018: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28873086/anti-mullerian-hormone-and-endometrial-cancer-a-multi-cohort-study
#17
Renée T Fortner, Helena Schock, Seungyoun Jung, Naomi E Allen, Alan A Arslan, Louise A Brinton, Brian L Egleston, Roni T Falk, Marc J Gunter, Kathy J Helzlsouer, Annika Idahl, Theron S Johnson, Rudolf Kaaks, Vittorio Krogh, Eva Lundin, Melissa A Merritt, Carmen Navarro, N Charlotte Onland-Moret, Domenico Palli, Xiao-Ou Shu, Patrick M Sluss, Paul N Staats, Antonia Trichopoulou, Elisabete Weiderpass, Anne Zeleniuch-Jacquotte, Wei Zheng, Joanne F Dorgan
BACKGROUND: The Mullerian ducts are the embryological precursors of the female reproductive tract, including the uterus; anti-Mullerian hormone (AMH) has a key role in the regulation of foetal sexual differentiation. Anti-Mullerian hormone inhibits endometrial tumour growth in experimental models by stimulating apoptosis and cell cycle arrest. To date, there are no prospective epidemiologic data on circulating AMH and endometrial cancer risk. METHODS: We investigated this association among women premenopausal at blood collection in a multicohort study including participants from eight studies located in the United States, Europe, and China...
October 24, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28802830/gfap-in-early-multiple-sclerosis-a-biomarker-for-inflammation
#18
Rebecca Kassubek, Martin Gorges, Michael Schocke, Viktoria A M Hagenston, André Huss, Albert C Ludolph, Jan Kassubek, Hayrettin Tumani
OBJECTIVE: The role of Glial Fibrillic Acidic Protein (GFAP) as a potential biomarker for relapsing-remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) has been controversially discussed. The aim was to characterize the added value of GFAP levels in the CSF of RRMS and CIS patients in correlation with MRI lesion load. MATERIALS & METHODS: GFAP levels in the CSF from 18 patients with RRMS, 8 patients with CIS and 35 controls were analyzed together with MRI data for acute and chronic inflammatory lesion load...
August 9, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28797521/increasing-chloride-in-rivers-of-the-conterminous-u-s-and-linkages-to-potential-corrosivity-and-lead-action-level-exceedances-in-drinking-water
#19
E G Stets, C J Lee, D A Lytle, M R Schock
Corrosion in water-distribution systems is a costly problem and controlling corrosion is a primary focus of efforts to reduce lead (Pb) and copper (Cu) in tap water. High chloride concentrations can increase the tendency of water to cause corrosion in distribution systems. The effects of chloride are also expressed in several indices commonly used to describe the potential corrosivity of water, the chloride-sulfate mass ratio (CSMR) and the Larson Ratio (LR). Elevated CSMR has been linked to the galvanic corrosion of Pb whereas LR is indicative of the corrosivity of water to iron and steel...
February 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28754794/a-comparative-study-on-the-wcrf-international-university-of-bristol-methodology-for-systematic-reviews-of-mechanisms-underpinning-exposure-cancer-associations
#20
REVIEW
Gökhan Ertaylan, Charlotte Le Cornet, Eline H van Roekel, Audrey Y Jung, Martijn J L Bours, Antje Damms-Machado, Piet A van den Brandt, Helena Schock, Theo M de Kok, Jan Theys, Ilja C W Arts, Rudolf Kaaks, Matty P Weijenberg, Renée Turzanski Fortner
The World Cancer Research Fund (WCRF) International and the University of Bristol have developed a novel framework for providing an overview of mechanistic pathways and conducting a systematic literature review of the biologically plausible mechanisms underlying exposure-cancer associations. Two teams independently applied the two-stage framework on mechanisms underpinning the association between body fatness and breast cancer to test the framework feasibility and reproducibility as part of a WCRF-commissioned validation study...
July 28, 2017: Cancer Epidemiology, Biomarkers & Prevention
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