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Christoph Scherfler, Alois Josef Schiefecker, Margarete Delazer, Ronny Beer, Thomas Bodner, Georg Spinka, Mario Kofler, Bettina Pfausler, Christian Kremser, Michael Schocke, Thomas Benke, Elke R Gizewski, Erich Schmutzhard, Raimund Helbok
OBJECTIVE: MRI parameters of iron concentration (R2*, transverse relaxation rate), microstructural integrity (mean diffusivity and fractional anisotropy), as well as gray and white matter volumes were analyzed in patients with subarachnoid hemorrhage (SAH) and uncomplicated clinical course to detect the evolution of brain tissue changes 3 weeks and 12 months after ictus. METHODS: MRI scans of 14 SAH patients (aneurysm of the anterior communicating artery, n = 5; no aneurysm n = 9) were compared with 14 age-matched healthy control subjects...
October 2016: Annals of Clinical and Translational Neurology
Jochen Friedemann, Ralf Heinrich, Yury Shulhevich, Matthias Raedle, Lena William-Olsson, Johannes Pill, Daniel Schock-Kusch
Transcutaneous measurement of the glomerular filtration rate (tGFR) is now frequently used in animal studies. tGFR allows consecutive measurements on the same animal, including multiple measurements on a daily basis, because no blood sampling is required. Here we derive and validate a novel kinetic model for the description of transcutaneously measured FITC-Sinistrin excretion kinetics. In contrast to standard 1- to 3-compartment models, our model covers the complete kinetic, including injection and distribution of the tracer in the plasma compartment...
September 21, 2016: Kidney International
Matthias Braito, Martina Wöß, Benjamin Henninger, Michael Schocke, Michael Liebensteiner, Dennis Huber, Martin Krismer, Rainer Biedermann
BACKGROUND: The purpose of this study was to investigate the radiological and surgical correlation between preoperative magnetic resonance images (MRI) and the intraoperative findings in patients with acquired adult flatfoot. RESULTS: The overall radiological-surgical correlation between preoperative MRI and the intraoperative findings for posterior tibial tendon insufficiency was only slight to fair in our patient's series. Comparing the most commonly used posterior tibial tendon classification systems, the classification of Rosenberg et al...
2016: SpringerPlus
Heike Eschenbeck, Vera Gillé, Uwe Heim-Dreger, Alexandra Schock, Andrea Schott
This study evaluated stressors and coping strategies in 70 children who are deaf or hard of hearing (D/HH) or with auditory processing disorder (APD) attending Grades 5 and 6 of a school for deaf and hard-of-hearing children. Everyday general stressors and more hearing-specific stressors were examined in a hearing-specific modified stress and coping questionnaire. Reports were compared with normative data for hearing children. Regarding everyday general stressors, stress levels for children who are D/HH or with APD did not differ from those of hearing children...
September 7, 2016: Journal of Deaf Studies and Deaf Education
Patricia Barra de la Tremblaye, Nicolas Narvaez Linares, Sarah Schock, Hélène Plamondon
Increased HPA axis activation and CRH release characterize the brain's response to global cerebral ischemia. Recently, CRH via activation of CRH type 1 receptors (CRHR1) has been shown to regulate Brain Derived Neurotrophic Factor (BDNF) secretion and emotional behavior. The current study investigates the impact of CRHR1 blockade on BDNF/TrkB signaling expression in the mesolimbic circuitry, and social and depressive-like behavior following global ischemia. Adult male Wistar rats were injected with Antalarmin (2μg/μl) or a vehicle 30min prior to 10min global cerebral ischemia (4VO model) or sham occlusion...
August 3, 2016: Experimental Neurology
Joshua S Winder, Brandon S Dudeck, Sarayna Schock, Jerome R Lyn-Sue, Randy S Haluck, Ann M Rogers
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease and the leading cause of cirrhosis in developed nations. Studies confirm improvement of liver histopathology after significant weight loss, but biochemistry and sonography do not always show this. Computed tomographic (CT) findings of NAFLD include low attenuation of liver parenchyma and hepatomegaly. We hypothesized that patients experiencing significant weight loss after laparoscopic Roux-en-Y gastric bypass (LRYGB) would show CT improvement of NAFLD...
July 20, 2016: Obesity Surgery
Hans-Josef Feistritzer, Gert Klug, Sebastian J Reinstadler, Martin Reindl, Agnes Mayr, Michael Schocke, Bernhard Metzler
OBJECTIVES: Measurement of aortic pulse wave velocity (PWV) is the gold standard for assessment of aortic stiffness. In patients with ST-segment elevation myocardial infarction (STEMI), high aortic PWV has deleterious effects on the myocardium. In the present study, we compared a novel oscillometric device with cardiac magnetic resonance (CMR) imaging for the assessment of aortic PWV in STEMI patients. METHODS: We measured aortic PWV in 60 reperfused STEMI patients using two different methods...
September 2016: Journal of Hypertension
Helena Schock, Anne Zeleniuch-Jacquotte, Eva Lundin, Kjell Grankvist, Hans-Åke Lakso, Annika Idahl, Matti Lehtinen, Heljä-Marja Surcel, Renée T Fortner
BACKGROUND: Evidence suggests that the hormonal milieu of pregnancy is an important determinant of subsequent cancer and other chronic diseases in both the mother and the offspring. Many of the existing maternity and birth cohorts include specimens drawn only once during pregnancy. How well a single blood specimen collected during a pregnancy characterizes exposure to these hormones throughout gestation, and also in subsequent pregnancies, is not well understood. METHODS: We used serial serum samples from 71 pregnant women (25 primiparous, 25 multiparous, and 21 with two consecutive pregnancies) with natural, complication-free pregnancies and a healthy offspring at term who participated in a population-based screening trial for congenital infections in Finland between January 1st, 1988 and June 30, 1989 and provided a blood sample in each trimester...
2016: BMC Pregnancy and Childbirth
Hamidreza Edrissi, Sarah C Schock, Robert Cadonic, Antoine M Hakim, Charlie S Thompson
Cerebral small vessel disease (CSVD) is a pathological process leading to lacunar infarcts, leukoaraiosis and cerebral microbleeds. Dysfunction of the blood brain barrier (BBB) has been proposed as a mechanism in the progression cerebral small vessel disease. A rodent model commonly used to study some aspects of CSVD is bilateral common carotid artery occlusion (BCCAO) in the rat. In the present study it was determined that gait impairment, as determined by a tapered beam test, and BBB permeability increased following BCCAO...
September 1, 2016: Brain Research
Anke Harsman, Annette Schock, Birgit Hemmis, Vanessa Wahl, Ingrid Jeshen, Philipp Bartsch, Armin Schlereth, Heidi Pertl-Obermeyer, Tom Alexander Goetze, Jürgen Soll, Katrin Philippar, Richard Wagner
Chloroplasts and mitochondria are unique endosymbiotic cellular organelles surrounded by two membranes. Essential metabolic networking between these compartments and their hosting cells requires the exchange of a large number of biochemical pathway intermediates in a directed and coordinated fashion across their inner and outer envelope membranes. Here, we describe the identification and functional characterization of a highly specific, regulated solute channel in the outer envelope of chloroplasts, named OEP40...
August 19, 2016: Journal of Biological Chemistry
Sebastian Stösser, Hermann Neugebauer, Katharina Althaus, Albert C Ludolph, Jan Kassubek, Michael Schocke
BACKGROUND: Perihematomal diffusion restriction (PDR) is a frequent finding in primary intracerebral hemorrhage (ICH) on diffusion-weighted MRI. Its frequency, associated clinical and imaging findings and impact on clinical outcome are not well understood. METHODS: This is a retrospective single-center analysis of 172 patients with primary ICH who received MRI within 24 h from symptom onset. PDR was defined as a reduction of apparent diffusion coefficient below 550 × 10-6 mm2/s...
2016: Cerebrovascular Diseases
Kathryn L Terry, Helena Schock, Renée T Fortner, Anika Hüsing, Raina N Fichorova, Hidemi S Yamamoto, Allison F Vitonis, Theron Johnson, Kim Overvad, Anne Tjønneland, Marie-Christine Boutron-Ruault, Sylvie Mesrine, Gianluca Severi, Laure Dossus, Sabina Rinaldi, Heiner Boeing, Vassiliki Benetou, Pagona Lagiou, Antonia Trichopoulou, Vittorio Krogh, Elisabetta Kuhn, Salvatore Panico, H Bas Bueno-de-Mesquita, N Charlotte Onland-Moret, Petra H Peeters, Inger Torhild Gram, Elisabete Weiderpass, Eric J Duell, Maria-Jose Sanchez, Eva Ardanaz, Nerea Etxezarreta, Carmen Navarro, Annika Idahl, Eva Lundin, Karin Jirström, Jonas Manjer, Nicholas J Wareham, Kay-Tee Khaw, Karl Smith Byrne, Ruth C Travis, Marc J Gunter, Melissa A Merritt, Elio Riboli, Daniel W Cramer, Rudolf Kaaks
PURPOSE: About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate early detection biomarkers. Here we evaluate the most promising ovarian cancer screening biomarkers in prospectively collected samples from the European Prospective Investigation into Cancer and Nutrition study...
September 15, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Roberto De Marzi, Klaus Seppi, Birgit Högl, Christoph Müller, Christoph Scherfler, Ambra Stefani, Alex Iranzo, Eduardo Tolosa, Joan Santamarìa, Elke Gizewski, Michael Schocke, Elisabeth Skalla, Christian Kremser, Werner Poewe
We assessed loss of dorsolateral nigral hyperintensity (DNH) on high-field susceptibility-weighted imaging (SWI), a novel magnetic resonance imaging marker for Parkinson's disease (PD), in 15 subjects with idiopathic rapid eye movement sleep behavior disorder (iRBD) and compared findings to 42 healthy controls (HCs) and 104 PD patients. We found loss of DNH in at least two thirds of iRBD subjects, which approaches the rate observed in PD and is in contrast to findings in HCs. We propose that absence of DNH on high-field SWI could identify prodromal degenerative parkinsonism in iRBD...
June 2016: Annals of Neurology
Yuan Binbin, Lu Jingping, Yang Bing, Chen Minglong, Zou Jiangang, Cao Kejiang, Shan Qijun
OBJECTIVE: To observe the long-term outcome of implantable cardioverter-defibrillator (ICD) implantation in Brugada syndrome patients and to explore how to reduce the frequency of ICD nappropriate schocks. METHODS: This study included 14 symptomatic patients (mean age (44.3 ± 8.3) years old; all males) with Brugada syndrome implanted with ICD in our hospital between 1998 and 2012, and these patients were followed up routinely every 6 months. The initial ICD parameters were set according o conventional experience...
August 2015: Zhonghua Xin Xue Guan Bing za Zhi
Christoph Scherfler, Georg Göbel, Christoph Müller, Michael Nocker, Gregor K Wenning, Michael Schocke, Werner Poewe, Klaus Seppi
OBJECTIVE: To determine whether automated and observer-independent volumetric MRI analysis is able to discriminate among patients with Parkinson disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) in early to moderately advanced stages of disease. METHODS: T1-weighted volumetric MRI from patients with clinically probable PD (n = 40), MSA (n = 40), and PSP (n = 30) and a mean disease duration of 2.8 ± 1.7 y were examined using automated volume measures of 22 subcortical regions...
March 29, 2016: Neurology
Tracey B Schock, Sheri Strickland, Edna J Steele, Daniel W Bearden
Environmental metabolomics studies employing earthworms as sentinels for soil contamination are numerous, but the instability of the metabolite extracts from these organisms has been minimally addressed. This study evaluated the efficacy of adding a heat-treatment step in two commonly used extraction protocols (Bligh and Dyer and D2O phosphate buffer) as a pre-analytical stabilization method. The resulting metabolic profiles of Eisenia fetida were assessed using principal component analysis and NMR spectral evaluations...
2016: Metabolomics: Official Journal of the Metabolomic Society
Hamidreza Edrissi, Sarah C Schock, Antoine M Hakim, Charlie S Thompson
Numbers of circulating microparticles (MPs) are elevated in a variety of cardiovascular disorders, and recent studies indicate that they are involved in inflammatory intercellular signaling. In the present study the signaling properties of MPs were assessed in an in vitro model of the blood brain barrier. MPs isolated from the plasma of rats exposed to chronic cerebral ischemia caused a significant reduction in the transendothelial electrical resistance (TEER) when applied to in vitro endothelial barriers, while MPs isolated from an equal volume of plasma from unoperated or sham operated rats did not...
March 1, 2016: Brain Research
Florian Rennebaum, Jan Kassubek, Elmar Pinkhardt, Annemarie Hübers, Albert C Ludolph, Michael Schocke, Susanne Fauser
OBJECTIVE: Incidence and localization of cortical and thalamic peri-ictal diffusion-weighted imaging (DWI) abnormalities were investigated in patients with status epilepticus (SE). Clinical characteristics and EEG features were compared between patients with and without peri-ictal regional DWI restriction. Such correlations are important to improve the understanding of causes and significance of peri-ictal DWI restriction. METHODS: We retrospectively investigated 69 SE-patients treated in our emergency department in whom SE was confirmed by EEG and MRI including DWI was performed...
February 2016: Epilepsy Research
Regina Esterhammer, Klaus Seppi, Eva Reiter, Bernadette Pinter, Christoph Mueller, Christian Kremser, Tanja Zitzelsberger, Michael Nocker, Christoph Scherfler, Werner Poewe, Michael Schocke
The purpose of the present study was to evaluate the potential of multimodal MR imaging including mean diffusivity (MD), fractional anisotropy (FA), relaxation rates R2 and R2* to detect disease specific alterations in Parkinson's Disease (PD). We enrolled 82 PD patients (PD-all) with varying disease durations (≤5 years: PD≤5, n = 43; >5 years: PD>5, n = 39) and 38 matched healthy controls (HC), receiving diffusion tensor imaging as well as R2 and R2* relaxometry calculated from multi-echo T2*-weighted and dual-echo TSE imaging, respectively...
2015: PloS One
George Wahba, Anne-Emilie Hebert, David Grynspan, William Staines, Sarah Schock
BACKGROUND: The enteric nervous system controls gastrointestinal functions such as secretion and smooth muscle contraction/relaxation. Neuronal enteric dysfunction is a feature of many direct gastrointestinal disorders and can be secondary to central nervous system disorders. Research in this field has been limited and there are few published methods on dissociated enteric cultures. NEW METHOD: Here we describe a quick and efficient method for culturing myenteric neurons which optimizes neuronal yield...
March 1, 2016: Journal of Neuroscience Methods
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