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JOURNAL ARTICLE
Christoph Cremer, Florian Schock, Antonio Virgilio Failla, Udo Birk
The structure of the cell nucleus of higher organisms has become a major topic of advanced light microscopy. So far, a variety of methods have been applied, including confocal laser scanning fluorescence microscopy, 4Pi, STED and localisation microscopy approaches, as well as different types of patterned illumination microscopy, modulated either laterally (in the object plane) or axially (along the optical axis). Based on our experience, we discuss here some application perspectives of Modulated Illumination Microscopy (MIM) and its combination with single-molecule localisation microscopy (SMLM)...
April 15, 2024: Journal of Microscopy
#2
JOURNAL ARTICLE
Lisa Schock, Witold X Chmielewski, Sonja Siegel, Mario Detomas, Timo Deutschbein, Sabrina Giese, Jürgen Honegger, Nicole Unger, Ilonka Kreitschmann-Andermahr
PURPOSE: Patients with acromegaly oftentimes exhibit a reduced physical and psychological health-related quality of life (HRQoL). Maladaptive coping styles are associated with poor HRQoL in a number of diseases and patients with pituitary adenomas in general exhibit less effective coping styles than healthy controls. This study aimed to assess coping strategies in acromegaly patients in order to explore leverage points for the improvement of HRQoL. METHODS: In this cross-sectional study, we administered self-report surveys for coping strategies and HRQoL (Short Form SF-36, Freiburg questionnaire on coping with illness, FKV-LIS) in patients with acromegaly...
April 13, 2024: Endocrine
#3
REVIEW
Goncalo Jorge Gouveia, Thomas Head, Leo L Cheng, Chaevien S Clendinen, John R Cort, Xiuxia Du, Arthur S Edison, Candace C Fleischer, Jeffrey Hoch, Nathaniel Mercaldo, Wimal Pathmasiri, Daniel Raftery, Tracey B Schock, Lloyd W Sumner, Panteleimon G Takis, Valérie Copié, Hamid R Eghbalnia, Robert Powers
BACKGROUND: The National Cancer Institute issued a Request for Information (RFI; NOT-CA-23-007) in October 2022, soliciting input on using and reusing metabolomics data. This RFI aimed to gather input on best practices for metabolomics data storage, management, and use/reuse. AIM OF REVIEW: The nuclear magnetic resonance (NMR) Interest Group within the Metabolomics Association of North America (MANA) prepared a set of recommendations regarding the deposition, archiving, use, and reuse of NMR-based and, to a lesser extent, mass spectrometry (MS)-based metabolomics datasets...
March 13, 2024: Metabolomics: Official Journal of the Metabolomic Society
#4
JOURNAL ARTICLE
Rebecca B Kriss, Emily Smith, Grace Byrd, Michael Schock, Marc A Edwards
Gaps in the United States Environmental Protection Agency (US EPA) Lead and Copper Rule (LCR) leave some consumers and their pets vulnerable to high cuprosolvency in drinking water. This study seeks to help proactive utilities who wish to mitigate cuprosolvency problems through the addition of orthophosphate corrosion inhibitors. The minimum doses of orthophosphate necessary to achieve acceptable cuprosolvency in relatively new copper pipe were estimated as a function of alkalinity via linear regressions for the 90th, 95th, and 100th percentile copper tube segments ( R 2 > 0...
March 12, 2024: Environmental Science & Technology
#5
JOURNAL ARTICLE
Jennifer Tully, Michael Schock, Scott Shilling, Valerie Bosscher, Darren Lytle, Stephen Harmon, Christina Bennett-Stamper
Communities across the United States and particularly in the Midwest continue to grapple with the complications associated with aging infrastructure. This includes the presence of lead (Pb)-bearing plumbing components such as lead service lines, downstream galvanized iron pipes, and Pb/tin solder. The community of Benton Harbor, MI, experienced six Pb action level exceedances between 2018 and 2021, leading to increasing community concern and a request from the state of Michigan for the US Environmental Protection Agency involvement...
February 2024: Journal of Water and Health
#6
REVIEW
Helmut U Klein, Hans-Joachim Trappe, Günter Frank
Direct current (DC) catheter ablation in 5 patients aiming to interrupt rapid atrioventricular (AV) conduction with atrial fibrillation and subsequent pacemaker implantation was first published by M. M. Scheinman et al. (San Francisco, CA, USA) in 1982. In Germany, L. Seipel, G. Breithardt, and M. Borggrefe reported their first experience with DC catheter ablation in 1984, followed by the group in Bonn (M. Manz and B. Lüderitz) in 1985. The first international DC catheter ablation registry, which also included four German centers, reported DC catheter ablation results of 127 patients in 24 centers in 1984...
February 29, 2024: Herzschrittmachertherapie & Elektrophysiologie
#7
JOURNAL ARTICLE
Clara D M van Karnebeek, Maja Tarailo-Graovac, René Leen, Rutger Meinsma, Solenne Correard, Judith Jansen-Meijer, Sergey V Prykhozhij, Izabella A Pena, Kevin Ban, Sarah Schock, Vishal Saxena, Mia L Pras-Raves, Britt I Drögemöller, Anita E Grootemaat, Nicole N van der Wel, Doreen Dobritzsch, Winfried Roseboom, Bauke V Schomakers, Yorrick R J Jaspers, Lida Zoetekouw, Jeroen Roelofsen, Carlos R Ferreira, Robin van der Lee, Colin J Ross, Jakub Kochan, Rebecca L McIntyre, Jan B van Klinken, Michel van Weeghel, Gertjan Kramer, Bernhard Weschke, Philippe Labrune, Michèl A Willemsen, Daria Riva, Barbara Garavaglia, John B Moeschler, James J Filiano, Marc Ekker, Jason N Berman, David Dyment, Frédéric M Vaz, Wyeth W Wassermann, Riekelt H Houtkooper, André B P van Kuilenburg
The functionality of many cellular proteins depends on cofactors, yet they have only been implicated in a minority of Mendelian diseases. Here, we describe the first two inherited disorders of the cytosolic iron-sulfur protein assembly system METHODS: Genetic testing via genome sequencing was applied to identify the underlying disease cause in 3 patients with microcephaly, congenital brain malformations, progressive developmental and neurologic impairments, recurrent infections, and a fatal outcome. Studies in patient-derived skin fibroblasts and zebrafish models were performed to investigate the biochemical and cellular consequences RESULTS: Metabolic analysis showed elevated uracil and thymine levels in body fluids but no pathogenic variants in DPYD...
February 24, 2024: Genetics in Medicine: Official Journal of the American College of Medical Genetics
#8
JOURNAL ARTICLE
Elena Bittner, Thorsten Stehlik, Jason Lam, Lazar Dimitrov, Thomas Heimerl, Isabelle Schöck, Jannik Harberding, Anita Dornes, Nikola Heymons, Gert Bange, Maya Schuldiner, Einat Zalckvar, Michael Bölker, Randy Schekman, Johannes Freitag
Peroxisomes are organelles with crucial functions in oxidative metabolism. To correctly target to peroxisomes, proteins require specialized targeting signals. A mystery in the field is the sorting of proteins that carry a targeting signal for peroxisomes and as well as for other organelles, such as mitochondria or the endoplasmic reticulum (ER). Exploring several of these proteins in fungal model systems, we observed that they can act as tethers bridging organelles together to create contact sites. We show that in Saccharomyces cerevisiae this mode of tethering involves the peroxisome import machinery, the ER-mitochondria encounter structure (ERMES) at mitochondria and the guided entry of tail-anchored proteins (GET) pathway at the ER...
February 20, 2024: PLoS Biology
#9
REVIEW
Jonathan D Mosley, Tracey B Schock, Chris W Beecher, Warwick B Dunn, Julia Kuligowski, Matthew R Lewis, Georgios Theodoridis, Candice Z Ulmer Holland, Dajana Vuckovic, Ian D Wilson, Krista A Zanetti
BACKGROUND: Quality assurance (QA) and quality control (QC) practices are key tenets that facilitate study and data quality across all applications of untargeted metabolomics. These important practices will strengthen this field and accelerate its success. The Best Practices Working Group (WG) within the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) focuses on community use of QA/QC practices and protocols and aims to identify, catalogue, harmonize, and disseminate current best practices in untargeted metabolomics through community-driven activities...
February 12, 2024: Metabolomics: Official Journal of the Metabolomic Society
#10
JOURNAL ARTICLE
Robert B Schock
No abstract text is available yet for this article.
February 5, 2024: Therapeutic Hypothermia and Temperature Management
#11
JOURNAL ARTICLE
Martin Mavany, Oliver Blankenstein, Christoph Bührer, Christof Dame
No abstract text is available yet for this article.
January 30, 2024: Klinische Pädiatrie
#12
Joshua R York, Anjali Rao, Paul B Huber, Elizabeth N Schock, Andrew Montequin, Sara Rigney, Carole LaBonne
The neural crest is vertebrate-specific stem cell population that helped drive the origin and evolution of the vertebrate clade. A distinguishing feature of these stem cells is their multi-germ layer potential, which has drawn developmental and evolutionary parallels to another stem cell population-pluripotent embryonic stem cells (animal pole cells or ES cells) of the vertebrate blastula. Here, we investigate the evolutionary origins of neural crest potential by comparing neural crest and pluripotency gene regulatory networks (GRNs) in both jawed ( Xenopus ) and jawless (lamprey) vertebrates...
December 22, 2023: bioRxiv
#13
JOURNAL ARTICLE
Sukru Akyuz, Ali Nazmi Calik, Tolga Onuk, Baris Yaylak, Zeynep Kolak, Semih Eren, Feyza Mollaalioglu, Furkan Durak, Mustafa Cetin, Ibrahim Halil Tanboga
BACKGROUND: Besides its primary clinical utility in predicting bleeding risk in patients with acute coronary syndrome (ACS), the PRECISE-DAPT (Predicting Bleeding Complications in Patients Undergoing Stent Implantation and Subsequent Dual Anti-Platelet Therapy) score may also be useful for predicting long-term mortality in ACS patients presenting with cardiogenic shock (CS) since several studies have reported an association between the score and certain cardiovascular conditions or events...
January 3, 2024: Herz
#14
JOURNAL ARTICLE
The Subdiaphragmatic Angle Of The Gastric Tube In Neonates - A Potential Predictor For Perforations?
Sonja Diez, Hilda Bartos, Anna Siemes, Hubert Gerleve, Alexandra Schock, Manuel Besendörfer, Andreas H Mahnken, Christel Weiß, Ursula Felderhoff-Müser, Hanna Müller
BACKGROUND: Traumatic subdiaphramatic perforation of esophagus or stomach in neonates represents a rare clinical complication following the insertion of a gastric tube and is associated with high morbidity and mortality. The aim of the present study was to evaluate whether the angle of the gastric tube depicted on a plain radiograph may serve as a diagnostic tool to predict subdiaphragmatic traumatic (or iatrogenic) perforation. PATIENTS AND METHODS: Thoraco-abdominal radiographs of 128 preterm and term neonates without perforation and 15 neonates with perforation of the esophagogastric junction or the stomach were retrospectively analysed...
December 14, 2023: Klinische Pädiatrie
#15
JOURNAL ARTICLE
Betül Toprak, Jessica Weimann, Jonas Lehmacher, Paul M Haller, Tau S Hartikainen, Alina Schock, Mahir Karakas, Thomas Renné, Tanja Zeller, Raphael Twerenbold, Nils A Sörensen, Dirk Westermann, Johannes T Neumann
BACKGROUND: The accurate identification of patients with high cardiovascular risk in suspected myocardial infarction (MI) is an unmet clinical need. Therefore, we sought to investigate the prognostic utility of a multi-biomarker panel with 29 different biomarkers in in 748 consecutive patients with symptoms indicative of MI using a machine learning-based approach. METHODS: Incident major cardiovascular events (MACE) were documented within 1 year after the index admission...
December 11, 2023: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
#16
JOURNAL ARTICLE
Elena Legrand, Amanda L Bayless, Daniel W Bearden, Fabio Casu, Michael Edwards, Annie Jacob, W Edward Johnson, Tracey B Schock
Bivalves serve as an ideal ecological indicator; hence, their use by the NOAA Mussel Watch Program to monitor environmental health. This study aimed to expand the baseline knowledge of using metabolic end points in environmental monitoring by investigating the dreissenid mussel metabolome in the field. Dreissenids were caged at four locations along the Maumee River for 30 days. The mussel metabolome was measured using nuclear magnetic resonance spectroscopy, and mussel tissue chemical contaminants were analyzed using gas or liquid chromatography coupled with mass spectrometry...
December 5, 2023: Environmental Science & Technology
#17
JOURNAL ARTICLE
Paul M Haller, Caroline Kellner, Nils A Sörensen, Jonas Lehmacher, Betül Toprak, Alina Schock, Tau S Hartikainen, Raphael Twerenbold, Tanja Zeller, Dirk Westermann, Johannes T Neumann
AIMS: Patients with acute or chronic myocardial injury are frequently identified in the context of suspected myocardial infarction (MI). We aimed to investigate their long-term follow-up. METHODS AND RESULTS: We prospectively enrolled 2714 patients with suspected MI and followed them for all-cause mortality and a composite cardiovascular endpoint (CVE; cardiovascular death, MI, unplanned revascularization) for a median of 5.1 years. Final diagnoses were adjudicated by two cardiologists according to the Fourth Universal Definition of MI, including 143 (5...
November 20, 2023: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
#18
MULTICENTER STUDY
Florian Krismer, Patrice Péran, Vincent Beliveau, Klaus Seppi, Germain Arribarat, Anne Pavy-Le Traon, Wassilios G Meissner, Alexandra Foubert-Samier, Margherita Fabbri, Michael M Schocke, Mark Forrest Gordon, Gregor K Wenning, Werner Poewe, Olivier Rascol, Christoph Scherfler
OBJECTIVE: To determine the rates of brain atrophy progression in vivo in patients with multiple system atrophy (MSA). BACKGROUND: Surrogate biomarkers of disease progression are a major unmet need in MSA. Small-scale longitudinal studies in patients with MSA using magnetic resonance imaging (MRI) to assess progression of brain atrophy have produced inconsistent results. In recent years, novel MRI post-processing methods have been developed enabling reliable quantification of brain atrophy in an automated fashion...
January 2024: Movement Disorders: Official Journal of the Movement Disorder Society
#19
JOURNAL ARTICLE
Alexander M Barlow, Sarah Tingvoll, Emily Gover, Alex Schock, David Finlay
Two juvenile red foxes (Vulpes vulpes) were euthanased because of severe nervous signs and paralysis. Detailed postmortem examinations were carried out with bacteriology, histology, and Clostridium botulinum toxin screening, which confirmed botulism as the cause of the clinical signs.
October 28, 2023: Journal of Wildlife Diseases
#20
JOURNAL ARTICLE
Jonas Lehmacher, Nils Arne Sörensen, Raphael Twerenbold, Alina Goßling, Paul Michael Haller, Tau Sarra Hartikainen, Alina Schock, Betül Toprak, Tanja Zeller, Dirk Westermann, Johannes Tobias Neumann
BACKGROUND: High-sensitivity cardiac troponin (hs-cTn) assays are used for detection of myocardial infarction (MI). 99th percentiles show wide inter-assay variation. Use of sex-specific cutoffs is recommended as definitory cutoff for MI. We compared diagnostic performance and prognostic value of sex-specific 99th percentiles of four hs-cTn assays in patients with suspected MI. METHODS: Concentrations of four hs-cTn assays were measured at presentation and after 3 hours in patients with suspected MI...
October 27, 2023: European Heart Journal. Acute Cardiovascular Care
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