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https://www.readbyqxmd.com/read/29035868/comparative-analysis-of-codon-usage-pattern-and-its-influencing-factors-in-schistosoma-japonicum-and-ascaris-suum
#1
Gulshana A Mazumder, Arif Uddin, Supriyo Chakraborty
Schistosoma japonicum and Ascaris suum are considered as the major parasites of human which cause various life threatening diseases such as schistomiasis and ascariasis. The codon usage bias (CUB) is known as the phenomenon of more usage of a specific codon than the other synonymous codons for an amino acid. The factors that influence the codon usage bias are mutation pressure, natural selection, gene expression, gene length, GC content, RNA stability, recombination rates, codon position etc. Here we had used various bioinformatic tools and statistical analyses to understand the compositional features, expression level and codon usage bias in the genes of these two species...
December 20, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/29035850/anti-angiogenic-and-anti-lymphangiogenic-role-of-praziquantel-and-artemether-in-experimental-mansoniasis
#2
Naglaa Fathy Abd El-Aal, Rania Said Hamza, Mona Magdy
Angiogenesis is one of the pillars of neoplasia. Lymphangiogenesis in context of granulomas is not yet understood. This study aimed to evaluate the role of praziquantel (PZQ) and artemether (ART) as anti-angiogenic and anti-lymphangiogenic drugs in Schistosoma mansoni induced experimental hepatic model through immunohistochemical and serological studies, this can be used as a potential novel prophylactic approach in hepatic malignancy prevention and possible management. Forty female CD-1 Swiss albino mice were used divided into 4 groups (10 mice each); control healthy, control infected untreated, PZQ-treated and ART-treated...
December 20, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/29032768/molluscicidal-effect-of-achyranthes-aspera-l-amaranthaceae-aqueous-extract-on-adult-snails-of-biomphalaria-pfeifferi-and-lymnaea-natalensis
#3
Belayhun Mandefro, Seid Tiku Mereta, Yinebeb Tariku, Argaw Ambelu
BACKGROUND: Intestinal schistosomiasis caused by Schistosoma mansoni is a wide spread disease in most parts of Ethiopian highlands. Snail control is one major strategy in schistosomiasis control. The use of molluscicidal plant products is becoming interesting due to their environmental friendliness, accessibility and easy application. This research is aimed to evaluate the molluscicidal effect of Achyranthes aspera on Biomphalaria pfeifferi and Lymnaea natalensis snails, which are of great medical and veterinary importance in Ethiopia...
October 16, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29032231/schistosoma-japonicum-presenting-as-colon-polyps
#4
Amirali Kiyani, Anika Walia, Keng-Yu Chuang
No abstract text is available yet for this article.
October 12, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29032230/schistosoma-haematobium-in-urine-cytology-diagnosis-is-possible
#5
Salvatore Bellafiore, Matteo Zanichelli, Simonetta Piana
No abstract text is available yet for this article.
October 12, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29029307/droplet-digital-pcr-diagnosis-of-human-schistosomiasis-parasite-cell-free-dna-detection-in-diverse-clinical-samples
#6
Kosala G Weerakoon, Catherine A Gordon, Gail M Williams, Pengfei Cai, Geoffrey N Gobert, Remigio M Olveda, Allen G Ross, David U Olveda, Donald P McManus
Background: Schistosomiasis japonica remains a major public health and socio-economic concern in Southeast-Asia. Sensitive and accurate diagnostics can play a pivotal role in achieving disease elimination goals. Methods: We previously reported a novel droplet digital-PCR (ddPCR) assay targeting the mitochondrial gene nad1 to diagnose schistosomiasis japonica. The tool identified both pre-patent and patent infections using Schistosoma japonicum DNA isolated from serum, urine, salivary glands and faeces in a murine model...
September 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29026995/cross-species-prophylactic-efficacy-of-sm-p80-based-vaccine-and-intracellular-localization-of-sm-p80-sm-p80-ortholog-proteins-during-development-in-schistosoma-mansoni-schistosoma-japonicum-and-schistosoma-haematobium
#7
Adebayo J Molehin, Souad R Sennoune, Weidong Zhang, Juan U Rojo, Arif J Siddiqui, Karlie A Herrera, Laura Johnson, Justin Sudduth, Jordan May, Afzal A Siddiqui
Schistosomiasis remains a major global health problem. Despite large-scale schistosomiasis control efforts, clear limitations such as possible emergence of drug resistance and reinfection rates highlight the need for an effective schistosomiasis vaccine. Schistosoma mansoni large subunit of calpain (Sm-p80)-based vaccine formulations have shown remarkable efficacy in protecting against S. mansoni challenge infections in mice and baboons. In this study, we evaluated the cross-species protective efficacy of Sm-p80 vaccine against S...
October 12, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29024873/photodynamic-therapy-for-schistosoma-mansoni-promising-outcomes
#8
Nathália Bandeira de Melo, Letícia Fernanda Moreira Dos Santos, Mayara Santos de Castro, Raquel Lopes Martins Souza, Marcos José Marques, Aline Pereira Castro, Andreísa Teixeira de Castro, Marina Lara de Carli, João Adolfo Costa Hanemann, Matheus Siqueira Silva, Gabriel de Oliveira Isac Moraes, Luiz Alberto Beijo, Maísa Ribeiro Pereira Lima Brigagão, Felipe Fornias Sperandio
The purpose of this study was to assess, for the very first time, the effects of photodynamic therapy (PDT) on Schistosoma mansoni in vitro by measuring reactive oxygen species (ROS) generation throughout the treatment, as well as the behavior of the parasites (mating, motility and contraction/shortening), and damage to their tegument and excretory systems. The parasites were divided into 4 groups: control, photosensitizer, laser and PDT. Light irradiation was delivered with an InGaAlP low-level laser device operating at 660nm, with 40mW and 100J/cm(2)...
September 22, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29022512/schistosoma-mansoni-purine-and-pyrimidine-biosynthesis-structures-and-kinetic-experiments-in-the-search-for-the-best-therapeutic-target
#9
Vitor Hugo Balasco Serrão, Humberto D'Muniz Pereira, Juliana Roberta Torini de Souza, Larissa Romanello
BACKGROUND: Schistosoma mansoni is the etiological agent of schistosomiasis, a debilitating treatment neglected tropical disease that affects approximately 218 million people worldwide. Despite its importance, the treatment of schistosomiasis relies on a single drug, praziquantel. Some reports on the resistance of S. mansoni to this drug have stimulated efforts to develop new drugs to treat this disease. S. mansoni possesses all the same pyrimidine pathways (de novo, salvage and thymidylate cycles) as those of its host...
October 11, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29018227/the-human-blood-parasite-schistosoma-mansoni-expresses-extracellular-tegumental-calpains-that-cleave-the-blood-clotting-protein-fibronectin
#10
Qiang Wang, Akram A Da'dara, Patrick J Skelly
Schistosomes are intravascular, parasitic flatworms that cause debilitating disease afflicting >200 million people. Proteins expressed at the host-parasite interface likely play key roles in modifying the worm's local environment to ensure parasite survival. Proteomic analysis reveals that two proteases belonging to the calpain family (SmCalp1 and SmCalp2) are expressed in the Schistosoma mansoni tegument. We have cloned both; while highly conserved in domain organization they display just 31% amino acid sequence identity...
October 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29017937/combined-treatment-of-biomphalaria-glabrata-infected-by-schistosoma-mansoni-with-oxamniquine-and-praziquantel-reproductive-histological-and-metabolic-aspects
#11
Rebecca Nespoli Lima, Paulo Marcos Zech Coelho, Ana Carolina A Mattos, Clélia Christina Mello Silva, Ronaldo de Carvalho Augusto, Ester Maria Mota, Samaly de Souza, Georgia Correa Atella, Suellen Silva Cabral, George Eduardo Gabriel Kluck, Marta Julia Faro
No abstract text is available yet for this article.
October 7, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/29017583/mapping-freshwater-snails-in-north-western-angola-distribution-identity-and-molecular-diversity-of-medically-important-taxa
#12
Fiona Allan, Jose Carlos Sousa-Figueiredo, Aidan M Emery, Rossely Paulo, Clara Mirante, Alfredo Sebastião, Miguel Brito, David Rollinson
BACKGROUND: This study was designed to determine the distribution and identity of potential intermediate snail hosts of Schistosoma spp. in Bengo, Luanda, Kwanza Norte and Malanje Provinces in north-western Angola. This is an area where infection with Schistosoma haematobium, causing urogenital schistosomiasis, is common but little is yet known about transmission of the disease. Angola has had a varied past with regard to disease control and is revitalising efforts to combat neglected tropical diseases...
October 10, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29017483/co-infection-of-schistosoma-mansoni-hepatitis-c-virus-and-their-associated-factors-among-adult-individuals-living-in-fishing-villages-north-western-tanzania
#13
Humphrey D Mazigo, Stella Kepha, Godfrey M Kaatano, Safari M Kinung'hi
BACKGROUND: Schistosoma mansoni and Hepatitis C virus (HCV) are co-existence in sub-Saharan Africa and co-infection is common among humans population. The immunological responses characterized with Th2-immune responses for S. mansoni and Th1-immune responses for HCV are responsible for development hepatic morbidities in infected individuals. However, the co-occurrences of S. mansoni and HCV infection, their related ultrasound detectable morbidities and associated risk factors at community levels have not been examined in fishing communities, north-western Tanzania...
October 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29016305/real-time-polymerase-chain-reaction-assay-on-bronchoalveolar-lavage-an-alternative-method-for-diagnosing-chronic-pulmonary-schistosomiasis
#14
Federico Gobbi, Fabio Formenti, Francesca Perandin, Dora Buonfrate, Andrea Angheben, Simona Paiano, Zeno Bisoffi
Schistosomiasis causes mainly hepatic and genitourinary damage. Although lung nodules have been commonly described in acute phase, they are presumably underdiagnosed in chronic schistosomiasis. We previously reported a series of patients with chronic pulmonary schistosomiasis confirmed by the histological examination of the lung biopsies. In the present work, we retrospectively tested an in-house real-time polymerase chain reaction for Schistosoma (currently validated for diagnosis on stool and on urine) in the bronchoalveolar lavage (BAL) of a couple of those patients, and both resulted positive...
October 9, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28994007/impact-of-moringa-oleifera-seed-aqueous-extract-on-some-biological-biochemical-and-histological-aspects-of-biomphalaria-alexandrina-snails
#15
Amina M Ibrahim, Aboelfetoh M Abdalla
Schistosomiasis is one of the neglected tropical diseases. It is a snail-borne trematode infection, and Biomphalaria alexandrina snails are the intermediate host of Schistosoma mansoni in Egypt. The objective of this study is to evaluate the molluscicidal activity of the aqueous seed extract of Moringa oleifera against B. alexandrina snails. The results showed that this aqueous extract was lethal for B. alexandrina snails (LC50 0.27 g/l; LC90 0.41 g/l). Exposure of snails to the sublethal concentrations of this aqueous extract caused a considerable reduction in survival rates and hatchability rates of eggs of these snails...
October 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28991894/sanitation-hookworm-anemia-stunting-and-wasting-in-primary-school-children-in-southern-ethiopia-baseline-results-from-a-study-in-30-schools
#16
Jack E T Grimes, Gemechu Tadesse, Iain A Gardiner, Elodie Yard, Yonas Wuletaw, Michael R Templeton, Wendy E Harrison, Lesley J Drake
BACKGROUND: Inadequate nutrition; neglected topical diseases; and insufficient water, sanitation, and hygiene (WASH) are interrelated problems in schools in low-income countries, but are not routinely tackled together. A recent three-year longitudinal study investigated integrated school health and nutrition approaches in 30 government primary schools in southern Ethiopia. Here, we report on baseline associations between sanitation, hookworm infection, anemia, stunting, and wasting. METHODS: In each school, the Schistosoma mansoni, S...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28985236/discovery-by-organism-based-high-throughput-screening-of-new-multi-stage-compounds-affecting-schistosoma-mansoni-viability-egg-formation-and-production
#17
Alessandra Guidi, Cristiana Lalli, Roberto Gimmelli, Emanuela Nizi, Matteo Andreini, Nadia Gennari, Fulvio Saccoccia, Steven Harper, Alberto Bresciani, Giovina Ruberti
Schistosomiasis, one of the most prevalent neglected parasitic diseases affecting humans and animals, is caused by the Platyhelminthes of the genus Schistosoma. Schistosomes are the only trematodes to have evolved sexual dimorphism and the constant pairing with a male is essential for the sexual maturation of the female. Pairing is required for the full development of the two major female organs, ovary and vitellarium that are involved in the production of different cell types such as oocytes and vitellocytes, which represent the core elements of the whole egg machinery...
October 6, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28983471/gene-duplication-analysis-reveals-no-ancient-whole-genome-duplication-but-extensive-small-scale-duplications-during-genome-evolution-and-adaptation-of-schistosoma-mansoni
#18
Shuai Wang, Xing-Quan Zhu, Xuepeng Cai
Gene duplication (GD), thought to facilitate evolutionary innovation and adaptation, has been studied in many phylogenetic lineages. However, it remains poorly investigated in trematodes, a medically important parasite group that has been evolutionarily specialized during long-term host-parasite interaction. In this study, we conducted a genome-wide study of GD modes and contributions in Schistosoma mansoni, a pathogen causing human schistosomiasis. We combined several lines of evidence provided by duplicate age distributions, genomic sequence similarity, depth-of-coverage and gene synteny to identify the dominant drivers that contribute to the origins of new genes in this parasite...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28983415/bilharzial-arthropathy-rare-cause-of-chronic-arthritis-in-tropical-areas
#19
Hoby N Rakotomalala, Maminirina V Ranaivoarison, Francia Andrianjafison, Dimby S Ralandison
Bilharziasis is a parasitic disease that affects the urinary tract and intestines. Finding bilharzia in joints is exceptional. We report two cases of Malagasy patients living in a highly endemic bilharziasis area and having chronic arthritis due to bilharziasis. The first case was a 32-year-old man presenting with a clinical picture of spondylitis with chronic oligoarthritis and paroxysmal asymmetric in his lower limbs, accompanied with sacroiliac pain and episodic dysentery. We retained the diagnosis of bilharziasis arthritis because of positive schistosomiasis serology in the joint fluid and the blood, poor response to therapy with nonsteroidal anti-inflammatory drugs (NSAIDs), and high efficacy of treatment with specific antiparasitic drugs...
September 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28979356/antiparasitic-activity-of-mirazid-myrrh-total-oil-and-nitazoxanide-compared-to-praziquantel-on-schistosoma-mansoni-scanning-electron-microscopic-study
#20
Mona El-Sayad, Sahar Abu Helw, Hend El-Taweel, Mohammad Aziz
BACKGROUND: The development of new antischistosomal drug remains a pressing need and a vital challenge in front of many researchers through screening the natural or chemical substances for their potential activity as antischistosomal agents. METHODS: Five groups of Schistosoma mansoni-infected mice (n=10) were enrolled in this study, the G1 was infected non-treated control group. G2 was infected treated with praziquantel 500 mg/kg for 2 consecutive days. G3 was given mirazid 500 mg/kg for 5 days...
July 2017: Iranian Journal of Parasitology
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