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https://www.readbyqxmd.com/read/28095839/erratum-to-ceratonia-siliqua-pod-extract-ameliorates-schistosoma-mansoni-induced-liver-fibrosis-and-oxidative-stress
#1
Ebtesam M Al-Olayan, Manal F El-Khadragy, Reem A Alajmi, Mohamed S Othman, Amira A Bauomy, Shaimaa R Ibrahim, Ahmed E Abdel Moneim
No abstract text is available yet for this article.
January 17, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28095417/schistosoma-mansoni-infection-of-mice-rats-and-humans-elicits-a-strong-antibody-response-to-a-limited-number-of-reduction-sensitive-epitopes-on-five-major-tegumental-membrane-proteins
#2
Greice Krautz-Peterson, Michelle Debatis, Jacqueline M Tremblay, Sergio C Oliveira, Akram A Da'dara, Patrick J Skelly, Charles B Shoemaker
Schistosomiasis is a major disease of the developing world for which no vaccine has been successfully commercialized. While numerous Schistosoma mansoni worm antigens have been identified that elicit antibody responses during natural infections, little is known as to the identities of the schistosome antigens that are most prominently recognized by antibodies generated through natural infection. Non-reducing western blots probed with serum from schistosome-infected mice, rats and humans on total extracts of larval or adult schistosomes revealed that a small number of antigen bands predominate in all cases...
January 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28094201/diagnosing-urogenital-schistosomiasis-dealing-with-diminishing-returns
#3
REVIEW
Loc Le, Michael H Hsieh
Urogenital schistosomiasis, caused by Schistosoma haematobium, is the most prevalent form of schistosomiasis affecting humans, and can result in severe bladder, kidney, ureteral, and genital pathologies. Chronic infection with S. haematobium has been linked with bladder cancer and increased risk for HIV infection. As mass drug administration with praziquantel increases in an attempt to transition from control to elimination of schistosomiasis, the need for updated, more sensitive diagnostic tools becomes more apparent, especially for use in areas of low infection intensity and for individuals with light infections...
January 13, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28079240/new-index-for-the-diagnosis-of-liver-fibrosis-in-schistosomiasis-mansoni
#4
Ana Virgínia Matos Sá Barreto, Vinícius Martins Alecrim, Tibério Batista de Medeiros, Ana Lúcia Coutinho Domingues, Edmundo Pessoa Lopes, João Roberto Maciel Martins, Helena Bonciani Nader, George Tadeu Nunes Diniz, Silvia Maria Lucena Montenegro, Clarice Neuenschwander Lins de Morais
BACKGROUND: - Periportal fibrosis is the major pathological consequence of the Schistosoma mansoni infection. OBJECTIVE: - To evaluate the accuracy of serum markers and to construct an index to assess fibrosis. METHODS: - Patients (n=116) with schistosomiasis were evaluated by ultrasound scan and measurements of serum levels of aminotransferases, γ-glutamyl transferase, alkaline phosphatase, hyaluronic acid, cytokines and platelets. Ultrasound images were used to evaluate the fibrosis using Niamey's classification and identified 19 patients without periportal fibrosis (patterns A and B), 48 with mild to moderate fibrosis (C and D) and 49 with advanced fibrosis (E and F)...
January 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28069074/a-next-generation-microarray-further-reveals-stage-enriched-gene-expression-pattern-in-the-blood-fluke-schistosoma-japonicum
#5
Pengfei Cai, Shuai Liu, Xianyu Piao, Nan Hou, Hong You, Donald P McManus, Qijun Chen
BACKGROUND: Schistosomiasis is caused by infection with blood flukes of the genus Schistosoma, and ranks, in terms of disability-adjusted life years (DALYs), as the third most important neglected tropical disease. Schistosomes have several discrete life stages involving dramatic morphological changes during their development, which require subtle gene expression modulations to complete the complex life-cycle. RESULTS: In the current study, we employed a second generation schistosome DNA chip printed with the most comprehensive probe array for studying the Schistosoma japonicum transcriptome, to explore stage-associated gene expression in different developmental phases of S...
January 10, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28066871/cysteine-protease-inhibitor-of-schistosoma-japonicum-a-parasite-derived-negative-immunoregulatory-factor
#6
Lin Chen, Baohua He, Wei Hou, Li He
Studies have shown that cysteine protease inhibitors from some parasites have immunosuppressive effects on the host. We previously have cloned a novel cysteine protease inhibitor from Schistosoma japonicum and purified its recombinant version (protein named rSj-C). Its possible inhibitory effect on the host immune response has not been described.This study shows that rSj-C inhibits lysosomal cysteine protease of murine dendritic cells (DCs). After DCs were incubated with rSj-C and then with soluble adult worm antigen (AWA) of S...
January 9, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28057071/parasitic-infections-and-maternal-anaemia-among-expectant-mothers-in-the-dangme-east-district-of-ghana
#7
Samuel Crowther Kofi Tay, Emmanuel Agbeko Nani, Williams Walana
BACKGROUND: Parasitic infections are of public health concern globally, particular among at risk groups such as pregnant women in developing countries. The presence of these parasites during pregnancy potentiate adverse effects to both the mother and the unborn baby. This study sought to establish the prevalence of some parasitic agents among antenatal attendees in the Dangme East District of Ghana. A cross-sectional prospective study was conduct between April and July, 2012. Venous blood specimens were collected from each participant for haemoglobin estimation and malaria microscopy...
January 3, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28051120/erratum-il-33-contributes-to-schistosoma-japonicum-induced-hepatic-pathology-through-induction-of-m2-macrophages
#8
Hui Peng, Qixian Zhang, Xiaojuan Li, Zhen Liu, Jia Shen, Rui Sun, Jie Wei, Jia Zhao, Xiaoying Wu, Feng Feng, Shuping Zhong, Xi Sun, Zhongdao Wu
No abstract text is available yet for this article.
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28051054/appendicular-bilharzioma-an-unusual-cause-of-acute-intestinal-obstruction-in-childhood-a-case-report-at-charles-de-gaulle-paediatric-teaching-hospital-of-ouagadougou
#9
Albert Wandaogo, Isso Ouédraogo, Toussaint Wendlamita Tapsoba, Emile Bandré, Francis Somkieta Ouédraogo, Bernadette Béré, Balima Elie
The authors report the case of a 12-year-old boy admitted to the surgical emergency department of Charles de Gaulle Paediatric Teaching Hospital of Ouagadougou for acute abdominal pain. A strangulation of the terminal ileum by a tumour-like appendix wound around the bowel loop was seen during operation. The histological examination of the removed appendix disclosed eggs of Schistosoma haematobium and concluded to bilharzian appendicitis. A course of praziquantel treatment was instituted, and the patient underwent an event-free recovery...
October 2016: African Journal of Paediatric Surgery: AJPS
https://www.readbyqxmd.com/read/28040484/development-of-an-experimental-model-of-schistosomal-myeloradiculopathy
#10
Tiago Pinheiro Vaz de Carvalho, Teresa Cristina Abreu Ferrari, Josimari Melo de Santana, Victor Antônio Santos Viana, José Aislan Correia Santos, Wheverton Correia do Nascimento, Kamilla Mayara Lucas da Cruz, Karina Conceição Gomes Machado de Araújo
Schistosomal myeloradiculopathy (SMR) is a severe form of presentation of schistosomiasis in which Schistosoma spp. affect the spinal cord. The aims of the present study were to develop an animal model of SMR caused by S. mansoni, to characterize both sensory and motor abnormalities in the infected animals, and to investigate the relationship of the sensory, motor and histological findings with the progression of the infection over time. Mechanical sensitivity and behavioral tests were performed followed by euthanasia in male Wistar rats divided into six groups of five animals each, on days 5, 10, 20 and 30 after infection of S...
December 28, 2016: Acta Tropica
https://www.readbyqxmd.com/read/28040482/schistosoma-antigens-downregulate-cxcl9-production-by-pbmc-of-htlv-1-infected-individuals
#11
Luciane Mota Lima, Luciana Santos Cardoso, Silvane Braga Santos, Ricardo Riccio Oliveira, Sérgio Costa Oliveira, Alfredo Miranda Góes, Alex Loukas, Maria Ilma Araujo
: HTLV-1 is the causal agent of Adult T cell Leukemia/lymphoma (ATLL) and HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). The immune response to HTLV-1-infection is polarized to the Th1-type, and the presence of CXCL9/CXCL10 chemokines may lead to an increase in the recruitment of pro-inflammatory molecules in spinal cord tissue, contributing to the damage observed in the development of HAM/TSP. It has been observed that in chronic helminth-infections, such as schistosomiasis, there is a deviation toward the Th2/regulatory immune response...
December 28, 2016: Acta Tropica
https://www.readbyqxmd.com/read/28040375/-epi-genetic-inheritance-in-schistosoma-mansoni-a-systems-approach
#12
REVIEW
Céline Cosseau, Olaf Wolkenhauer, Gilda Padalino, Kathrin K Geyer, Karl F Hoffmann, Christoph Grunau
The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by 'inheritance system'. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success...
December 28, 2016: Trends in Parasitology
https://www.readbyqxmd.com/read/28036393/soluble-egg-antigens-of-schistosoma-japonicum-induce-senescence-of-activated-hepatic-stellate-cells-by-activation-of-the-foxo3a-skp2-p27-pathway
#13
Yinong Duan, Jing Pan, Jinling Chen, Dandan Zhu, Jianxin Wang, Xiaolei Sun, Liuting Chen, Liting Wu
BACKGROUND: Liver fibrosis was viewed as a reversible process. The activation of hepatic stellate cells (HSCs) is a key event in the process of liver fibrosis. The induction of senescence of HSCs would accelerate the clearance of the activated HSCs. Previously, we demonstrated that soluble egg antigens (SEA) of Schistosoma japonicum promoted the senescence of HSCs via STAT3/P53/P21 pathway. In this paper, our study was aimed to explore whether there are other signaling pathways in the process of SEA-induced HSCs aging and the underlying effect of SKP2/P27 signal on senescent HSCs...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28030359/exploring-possibilities-for-an-alternative-approach-in-experimental-schistosomiasis-mansoni-the-peritoneal-cavity-of-mice
#14
Vitor L T Mati, Rosilene S Bicalho, Alan L Melo
The schistosome oviposition and granuloma constitution in the peritoneal cavity of AKR/J mice were evaluated. Groups of mice intraperitoneally infected with cercariae of Schistosoma mansoni were weekly euthanized during the acute (56 to 84 days post-infection (DPI)) and chronic (147 to 175 DPI) phase of infection. Schistosome developmental stages obtained via peritoneal lavage and perfusion of the portal system were inspected, counted and fixed, and peritoneal granulomata were then processed for histology. The morphological characterization and quantitative analysis of peritoneal schistosome eggs and granulomata were for the first time performed, such as the demonstration of the viability of miracidia obtained there from...
March 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28030347/reduced-14c-methionine-uptake-and-fecundity-in-schistosoma-mansoni-females-treated-with-recombinant-tumor-necrosis-factor-%C3%AE-in-vitro
#15
M A Haseeb, Raag Agrawal, Bernard Fried
Recombinant human TNFα (rhTNFα) has previously been shown to reduce fecundity in Schistosoma mansoni adult females maintained in vitro without males, and adversely affect the uptake of [14C]-tyrosine, an amino acid required for schistosome vitellogenesis. Here we report on the effect of rhTNFα on [14C]-methionine uptake in both separated and paired females, and the effect of three different preparations of rTNFα on schistosome oviposition in vitro. In the absence of rhTNFa, separated females incorporated only 30% of the [14C]-methionine incorporated by paired females in a dose and time-dependent manner, suggesting low metabolic activity of females in the absence of males...
March 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28027317/infection-with-schistosoma-mansoni-has-an-effect-on-quality-of-life-but-not-on-physical-fitness-in-schoolchildren-in-mwanza-region-north-western-tanzania-a-cross-sectional-study
#16
Safari Kinung'hi, Pascal Magnussen, Godfrey Kaatano, Annette Olsen
BACKGROUND: Infection with Schistosoma mansoni negatively impact children's physical health and may influence their general well-being. The aim of this study was to investigate the effect of S. mansoni infections on a panel of morbidity indicators with emphasis on quality of life (PedsQL; measured in four different dimensions) and physical fitness (measured as VO2 max) among 572 schoolchildren aged 7-8 years. METHODOLOGY/PRINCIPAL FINDINGS: Prevalence of S. mansoni infections was 58...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28018158/estrogen-catechols-detection-as-biomarkers-in-schistosomiasis-induced-cancer-and-infertility
#17
M C Botelho, H Alves, J Richter
Urogenital schistosomiasis is a chronic infection caused by the human blood fluke Schistosoma haematobium. Schistosomiasis haematobium is a known risk factor for cancer leading to squamous cell carcinoma of the urinary bladder (SCC). This is a neglected tropical disease endemic in many countries of Africa and the Middle East. Schistosome eggs produce catechol-estrogens. These molecules are metabolized to active quinones that cause alterations in DNA (leading in other contexts to breast or thyroid cancer). Our group have shown that schistosome egg associated catechol estrogens induce tumor-like phenotypes in urothelial cells, originated from parasite estrogen-host cell chromosomal DNA adducts and mutations...
2017: Letters in Drug Design & Discovery
https://www.readbyqxmd.com/read/28017859/antiparasitic-activity-of-menadione-vitamin-k3-against-schistosoma-mansoni-in-babl-c-mice
#18
Govind J Kapadia, Ingrid A O Soares, G Subba Rao, Fernanda R Badoco, Ricardo A Furtado, Mariana B Correa, Denise C Tavares, Wilson R Cunha, Lizandra G Magalhães
Schistosomiasis is one of the neglected tropical diseases affecting nearly quarter of a billion people in economically challenged tropical and subtropical countries of the world. Praziquantel (PZQ) is the only drug currently available to treat this parasitic disease in spite being ineffective against juvenile worms and concerns about developing resistance to treat reinfections. Our earlier in vitro viability studies demonstrated significant antiparasitic activity of menadione (MEN) (vitamin K3) against Schistosoma mansoni adult worms...
December 23, 2016: Acta Tropica
https://www.readbyqxmd.com/read/28017636/identification-and-first-characterization-of-smeps8-a-potential-interaction-partner-of-smtk3-and-ser-transcribed-in-the-gonads-of-schistosoma-mansoni
#19
C Buro, C Burmeister, T Quack, C G Grevelding
In eukaryotes the roles of protein kinases (PKs) regulating important biological processes such as growth and differentiation are well known. Molecular, biochemical, and physiological analyses trying to unravel principles of schistosome development have substantiated the importance for PKs also in this parasite. Amongst others the role of SmTK3 was studied, one of the first cellular PKs characterized from Schistosoma mansoni. Its function was demonstrated in mitogenic and differentiation processes in the gonads...
December 22, 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/28012902/first-characterization-of-viruses-from-freshwater-snails-of-the-genus-biomphalaria-the-intermediate-host-of-the-parasite-schistosoma-mansoni
#20
Richard Galinier, Guillaume Tetreau, Anaïs Portet, Silvain Pinaud, David Duval, Benjamin Gourbal
We report the genome sequence and organization of five viruses infecting snails of both Biomphalaria glabrata and Biomphalaria pfeifferi, which are vectors of the intestinal schistosomiasis. Four viruses presented a polyadenylated positive single strand RNA genome encoding one or two large open reading frames (ORFs) flanked by untranslated region. Conserved protein motifs typical of the picorna-like virus superfamily were identified in these viruses but they all presented different genome organization. Phylogenetic analysis confirmed their assignment to this superfamily...
December 22, 2016: Acta Tropica
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