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https://www.readbyqxmd.com/read/29228024/detection-of-duo-schistosome-infection-from-filtered-urine-samples-from-school-children-in-zambia-after-mda
#1
Megan J Hessler, Austin Cyrs, Steven C Krenzke, El Shaimaa Mahmoud, Chummy Sikasunge, James Mwansa, Nilanjan Lodh
Schistosomiasis is one of the major Neglected Tropical Diseases (NTDs) in sub-Saharan Africa. In sub-Saharan Africa, two major human schistosome species namely Schistosoma mansoni and S. haematobium often occur sympatrically largely affecting children. Recognizing the public health impact of Schistosomiasis, the World Health Organization (WHO) is urging member states to regularly treat at least 75% and up to 100%, of all school-aged children at risk of morbidity. For control strategies based on targeted mass drug administration (MDA) to succeed it is essential to have a simple and sensitive test for monitoring the success of these interventions...
2017: PloS One
https://www.readbyqxmd.com/read/29225201/3-bromopyruvate-as-a-potential-pharmaceutical-in-the-light-of-experimental-data
#2
Izabela Szczuka, Andrzej Gamian, Grzegorz Terlecki
3-Bromopyruvate (3-BrPA) is an halogenated analogue of pyruvic acid known for over four decades as an alkylating agent reacting with thiol groups of many proteins. It enters animal cells like a lactate: via monocarboxylic acid transporters. Increasing interest in this compound, in recent times, is mainly due to hopes associated with its anticancer action. It is based on the impairment of energy metabolism of tumor cells by inhibiting enzymes in the glycolysis pathway (hexokinase II, glyceraldehyde 3-phosphate dehydrogenase, phosphoglycerate kinase) and the oxidative phosphorylation (succinate dehydrogenase)...
December 8, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29220354/interpreting-ambiguous-trace-results-in-schistosoma-mansoni-cca-tests-estimating-sensitivity-and-specificity-of-ambiguous-results-with-no-gold-standard
#3
Michelle N Clements, Christl A Donnelly, Alan Fenwick, Narcis B Kabatereine, Sarah C L Knowles, Aboulaye Meité, Eliézer K N'Goran, Yolisa Nalule, Sarah Nogaro, Anna E Phillips, Edridah Muheki Tukahebwa, Fiona M Fleming
BACKGROUND: The development of new diagnostics is an important tool in the fight against disease. Latent Class Analysis (LCA) is used to estimate the sensitivity and specificity of tests in the absence of a gold standard. The main field diagnostic for Schistosoma mansoni infection, Kato-Katz (KK), is not very sensitive at low infection intensities. A point-of-care circulating cathodic antigen (CCA) test has been shown to be more sensitive than KK. However, CCA can return an ambiguous 'trace' result between 'positive' and 'negative', and much debate has focused on interpretation of traces results...
December 8, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29217943/intestinal-parasitosis-and-their-associated-factors-among-people-living-with-hiv-at-university-of-gondar-hospital-northwest-ethiopia
#4
Tegegne Eshetu, Getinet Sibhatu, Mohammed Megiso, Abrham Abere, Habtamu Wondifraw Baynes, Belete Biadgo, Ayalew Jejaw Zeleke
Background: Most HIV clients die of AIDS related intestinal parasitic infections rather than due to the HIV infection itself. Therefore, this study was aimed at determining the prevalence of intestinal parasite and their associated factors among HIV/AIDS clients at the University of Gondar Hospital, Northwest Ethiopia. Methods: Institution based cross sectional study was conducted using systematic random sampling technique from March to May 2016. A semi-structured questionnaire was used to collect data...
July 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29205689/ultrasound-findings-and-associated-factors-to-morbidity-in-schistosoma-haematobium-infection-in-a-highly-endemic-setting
#5
Cristina Bocanegra García, Zeferino Pintar, Xavier Serres, Jacobo Mendioroz, Milagros Moreno, Sara Gallego, Teresa López, Antoni Soriano-Arandes, Maria Luisa Aznar, Nicolau Sikaleta, Eva Gil, Fernando Salvador, Israel Molina
OBJECTIVE: To evaluate the usefulness of the WHO classification of ultrasound pathological changes and to establish risk factors for morbidity in a highly endemic setting. METHODS: 157 ultrasounds were performed on school-aged children previously diagnosed with urinary schistosomiasis in Cubal, Angola. The findings were analysed according to WHO guidelines. Factors for morbidity were studied. RESULTS: Mean age of the children was 8.7 (SD 3...
December 4, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29202865/prevalence-and-intensity-of-schistosoma-mansoni-infections-among-schoolchildren-attending-primary-schools-in-an-urban-setting-in-southwest-ethiopia
#6
Mitiku Bajiro, Daniel Dana, Bruno Levecke
OBJECTIVE: To determined both prevalence and intensity of Schistosoma mansoni infections among schoolchildren attending primary schools in Jimma town, an urban setting, Southwest, Ethiopia. RESULTS: The prevalence of S. mansoni infections was 8.4%. S. mansoni infections were found in all 17 schools, but the school prevalence ranged from 1.7 to 26.7%. This variation in prevalence could be explained by the proximity of the schools to the river crossing the town and water bodies near the schools...
December 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29197426/phenotypic-and-genotypic-monitoring-of-schistosoma-mansoni-in-tanzanian-schoolchildren-five-years-into-a-preventative-chemotherapy-national-control-programme
#7
Charlotte M Gower, Florian Gehre, Sara R Marques, Poppy H L Lamberton, Nicholas J Lwambo, Joanne P Webster
BACKGROUND: Schistosoma mansoni is a parasite of profound medical importance. Current control focusses on mass praziquantel (PZQ) treatment of populations in endemic areas, termed Preventative Chemotherapy (PC). Large-scale PC programmes exert prolonged selection pressures on parasites with the potential for, direct and/or indirect, emergence of drug resistance. Molecular methods can help monitor genetic changes of schistosome populations over time and in response to drug treatment, as well as estimate adult worm burdens through parentage analysis...
December 2, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29196196/molluscicidal-activity-of-manilkara-subsericea-mart-dubard-on-biomphalaria-glabrata-say-1818
#8
Robson Xavier Faria, Leandro Machado Rocha, Eloísa Portugal Barros Silva Soares Souza, Fernanda Borges Almeida, Caio Pinho Fernandes, José Augusto Albuquerque Santos
Schistosomiasis is promoted for species from Schistosoma genus affecting over 200 million people worldwide. Molluscicides are an efficient method to control this disease, being able to reduce intermediate host snail Biomphalaria glabrata number. In function of resistance cases using niclosamide, natural products are promisors to discover new drugs. Manilkara subsericea is endemic to Brazilian sandbanks of Rio de Janeiro State and wide ranges of biological activities. However, there is no studies evaluating its effects as molluscicidal agent...
November 30, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29188369/immune-modulation-of-th1-th2-and-t-reg-transcriptional-factors-differing-from-cytokine-levels-in-schistosoma-japonicum-infection
#9
Amel Farwa, Chao He, Longfei Xia, Hong Zhou
In spite of long-term integrated control programs for Schistosoma japonicum infection in China, the infection is still persistent due to its zoonotic transmission and disease severity which further complicate its control. Th1, Th2, and T-reg cells are involved in S. japonicum immunity; however, their exact roles in immunopathology of this infection are still questionable. Therefore, the monitoring of these T cell subsets' immune responses during a primary infection of S. japonicum at both transcriptional (mRNA) and protein (cytokines) levels would be essential to point out...
November 29, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29187698/evaluation-of-schistosoma-japonicum-thioredoxin-peroxidase-1-as-a-potential-circulating-antigen-target-for-the-diagnosis-of-asian-schistosomiasis
#10
Adrian Miki C Macalanda, Jose Ma M Angeles, Kharleezelle J Moendeg, Anh Tm Dang, Luna Higuchi, Noboru Inoue, Xuenan Xuan, Masashi Kirinoki, Yuichi Chigusa, Lydia R Leonardo, Elena A Villacorte, Pilarita T Rivera, Yasuyuki Goto, Shin-Ichiro Kawazu
Asian schistosomiasis caused by Schistosoma japonicum is a serious zoonotic disease endemic in China, the Philippines and parts of Indonesia. Mass drug administration in endemic areas resulted to decline in disease severity and intensity. The low intensity of infection limits the use of current parasitological methods for schistosomiasis diagnosis. Detection of parasite circulating antigens might provide more informative result as it may indicate the true status of infection. In this study, S. japonicum thioredoxin peroxidase-1 (SjTPx-1) a 22 kDa secreted antioxidant enzyme expressed throughout the life stages of the parasite was evaluated for its potential use as a biomarker for schistosomiasis japonica infection...
November 28, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29183718/identification-and-characterization-of-pp2c-phosphatase-sjptc1-in-schistosoma-japonicum
#11
Yunfeng Lu, Yongwei Qin, Dandan Zhu, Aidi Shan, Jinrong Feng
Protein phosphorylation, regulated by protein kinases and protein phosphatases, is crucial for protein structure and function in eukaryotic organisms. Type 2C protein phosphatase (PP2C) belongs to the serine/threonine phosphatase family and its activities require the presence of a divalent magnesium or manganese ion. In the present study, a potential PP2C phosphatase (SjPtc1) was identified in Schistosoma japonicum. The SjPTC1 gene was found to be highly expressed in adult worms. A recombinant SjPtc1 protein showed typical PP2C phosphatase activity...
November 25, 2017: Parasitology International
https://www.readbyqxmd.com/read/29183397/schistosomiasis-intestinal-helminthiasis-and-nutritional-status-among-preschool-aged-children-in-sub-urban-communities-of-abeokuta-southwest-nigeria
#12
Adebiyi Abdulhakeem Adeniran, Hammed Oladeji Mogaji, Adeyinka A Aladesida, Ibiyemi O Olayiwola, Akinola Stephen Oluwole, Eniola Michael Abe, Dorcas B Olabinke, Oladimeji Michael Alabi, Uwem Friday Ekpo
OBJECTIVE: Schistosomiasis and intestinal helminthiasis are major public health problems with school-aged children considered the most at-risk group. Pre-school aged children (PSAC) are excluded from existing control programs because of limited evidence of infections burden among the group. We assessed the prevalence of infections and effect on nutritional status of preschool aged children in Abeokuta, Southwestern Nigeria. RESULTS: A community-based cross-sectional study involving 241 children aged 0-71 months was conducted in 4 sub-urban communities of Abeokuta...
November 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29182577/estrogen-metabolism-associated-cyp2d6-and-il6-174g-c-polymorphisms-in-schistosoma-haematobium-infection
#13
Rita Cardoso, Pedro C Lacerda, Paulo P Costa, Ana Machado, André Carvalho, Adriano Bordalo, Ruben Fernandes, Raquel Soares, Joachim Richter, Helena Alves, Monica C Botelho
Schistosoma haematobium is a human blood fluke causing a chronic infection called urogenital schistosomiasis. Squamous cell carcinoma of the urinary bladder (SCC) constitutes chronic sequelae of this infection, and S. haematobium infection is accounted as a risk factor for this type of cancer. This infection is considered a neglected tropical disease and is endemic in numerous countries in Africa and the Middle East. Schistosome eggs produce catechol-estrogens. These estrogenic molecules are metabolized to active quinones that induce modifications in DNA...
November 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29181419/decrease-in-seminal-hiv-1-rna-load-after-praziquantel-treatment-of-urogenital-schistosomiasis-coinfection-in-hiv-positive-men-an-observational-study
#14
Nicholas Midzi, Takafira Mduluza, Boniface Mudenge, Leslie Foldager, Peter D C Leutscher
Background: Urogenital schistosomiasis due to Schistosoma hematobium infection is hypothesized to cause increased HIV-1 RNA shedding in semen in HIV co-infected men as result of chronic egg-induced inflammation in the prostate and the seminal vesicles. The effect of treatment with the antihelminthic agent praziquantel on seminal HIV-1 RNA load was assessed in this study. Methods: HIV-1 RNA load was determined in blood plasma and semen at baseline and at 10-week follow-up...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29176778/cross-sectional-interview-study-of-fertility-pregnancy-and-urogenital-schistosomiasis-in-coastal-kenya-documented-treatment-in-childhood-is-associated-with-reduced-odds-of-subfertility-among-adult-women
#15
Sarah C Miller-Fellows, Laura Howard, Rebekah Kramer, Vanessa Hildebrand, Jennifer Furin, Francis M Mutuku, Dunstan Mukoko, Julianne A Ivy, Charles H King
BACKGROUND: Previous research has documented an increased risk of subfertility in areas of sub-Saharan Africa, as well as an ecological association between urogenital schistosomiasis prevalence and decreased fertility. This pilot project examined reproductive patterns and the potential effects of childhood urogenital Schistosoma haematobium infection and individual treatment experience on adult subfertility among women who were long-term residents in an S. haematobium-endemic region of coastal Kenya...
November 27, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29175593/rational-selection-of-immunodominant-and-preserved-epitope-sm043300e-from-schistosoma-mansoni-and-design-of-a-chimeric-molecule-for-biotechnological-purposes
#16
Cláudia de Souza, Marcelo Donizete Lopes, Flávio Martins De Oliveira, Maria Juliana Ferreira Passos, Laís Cunha Grossi Ferreira, Bruna Franciele Faria, José Augusto Ferreira Perez Villar, Moacyr Comar Junior, Alex Guterres Taranto, Luciana Lara Dos Santos, Cristina Toscano Fonseca, Débora de Oliveira Lopes
Human schistosomiasis is a neglected tropical disease of great importance in public health. A large number of people are infected with schistosomiasis, making vaccine development and effective diagnosis important control strategies. A rational epitope prediction workflow using Schistosoma mansoni hypothetical proteins was previously presented by our group, and an improvement to that approach is presented here. Briefly, immunodominant epitopes from parasite membrane proteins were predicted by reverse vaccinology strategy with additional in silico analysis...
November 22, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29172838/in-vitro-schistosomicidal-activity-of-the-lignan-6-6-dinitrohinokinin-dnhk-loaded-into-poly-lactic-co-glycolic-acid-nanoparticles-against-schistosoma-mansoni
#17
Thaís C Lima, Rodrigo Lucarini, Priscilla P Luz, Emerson H de Faria, Liziane Marçal, Lizandra G Magalhães, Fernanda R Badoco, Viviane R Esperandim, Eduardo F Molina, Rosangela S Laurentz, Regiane G Lima, Wilson R Cunha, Jairo K Bastos, Marcio L Andrade Silva
CONTEXT: (-)-6,6'-Dinitrohinokinin (DNHK) display remarkable antiparasitic activity and was, therefore, incorporated into a nanoparticle formulation. OBJECTIVE: Incorporation of DNHK in poly lactic-co-glycolic acid (PLGA) nanoparticles aiming to improve its biological activities. MATERIALS AND METHODS: Synthesis, characterization and incorporation of DNHK into glycolic acid (PLGA) nanoparticles by nanoprecipitation method. The nanoparticles were characterized by ultraviolet-visible spectroscopy, X-ray diffraction, field emission electron microscopic scanning mansoni (FESEM), and dynamic light scattering (DLS)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29171863/schistosoma-mansoni-specific-immune-responses-and-allergy-in-uganda
#18
Gyaviira Nkurunungi, Joyce Kabagenyi, Margaret Nampijja, Richard E Sanya, Bridgious Walusimbi, Jacent Nassuuna, Emily L Webb, Alison M Elliott
Low allergy-related disease (ARD) prevalence in low-income countries may be partly attributed to helminth infections. In the Schistosoma mansoni (Sm)-endemic Lake Victoria islands (Uganda), we recently observed positive helminth-allergy associations, despite low ARD prevalence. To understand how Sm-induced cytokine and antibody profiles might influence allergic response profiles in this population, we assessed Schistosoma worm (SWA)- and egg antigen (SEA)-specific Th1 (IFN-γ), Th2 (IL-5, IL-13) and regulatory (IL-10) cytokine profiles (n=407), and total (n=471), SWA-, SEA- and allergen (house dust mite [HDM] and cockroach)-specific (as)IgE and IgG4 profiles (n=2117) by ELISA...
November 24, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/29169803/expression-purification-and-characterization-of-two-leucine-aminopeptidases-of-the-blood-fluke-schistosoma-mansoni
#19
Gabriela Maggioli, Gabriel Rinaldi, Ines Giaudrone, Patricia Berasain, José F Tort, Paul J Brindley, Carlos Carmona
Schistosomiasis is a major neglected tropical disease (NTD) and considered the most important of the human helminthiases in terms of morbidity and mortality. Whereas treatment with praziquantel has been effective since the 1980s, the potential for the emergence of drug resistance has propelled the search for new interventions. Studies have revealed key roles of proteases in parasitic helminths during establishment of infection, tissue invasion, immune evasion, parasite feeding and development throughout the different developmental stages, pinpointing them as possible candidates...
November 20, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/29169384/assessing-s-mansoni-prevalence-in-biomphalaria-snails-in-the-gombe-ecosystem-of-western-tanzania-the-importance-of-dna-sequence-data-for-clarifying-species-identification
#20
Jared S Bakuza, Robert Gillespie, Gamba Nkwengulila, Aileen Adam, Elizabeth Kilbride, Barbara K Mable
BACKGROUND: Snails are essential for the transmission and maintenance of schistosomiasis in endemic areas, as they serve as intermediate hosts for schistosome parasites. A clear understanding of the snail species present, their local distribution and infection status is therefore a prerequisite for effective control of schistosomiasis. The purpose of this study was to establish the infection status and distribution of Schistosoma mansoni in snails in the Gombe area along the shores of Lake Tanganyika in western Tanzania, using both detection of cercarial shedding and molecular approaches...
November 23, 2017: Parasites & Vectors
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