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https://www.readbyqxmd.com/read/29453993/the-tegumental-allergen-like-proteins-of-schistosoma-mansoni-a-biochemical-study-of-smtal4-tal13
#1
Jack Carson, Charlotte M Thomas, Aaron McGinty, Gustavo Takata, David J Timson
Schistosoma mansoni, like other trematodes, expresses a number of unusual calcium binding proteins which consist of an EF-hand domain joined to a dynein light chain-like (DLC-like) domain by a flexible linker. These proteins have been implicated in host immune responses and drug binding. Three members of this protein family from S. mansoni (SmTAL1, SmTAL2 and SmTAL3) have been well characterised biochemically. Here we characterise the remaining family members from this species (SmTAL4-13). All of these proteins form homodimers and all except SmTAL5 bind to calcium and manganese ions...
February 14, 2018: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/29453950/towards-elimination-of-schistosomiasis-after-5000-years-of-endemicity-in-egypt
#2
REVIEW
Iman F Abou-El-Naga
Schistosomiasis is a snail-transmitted infectious disease caused by a long lasting infection with a blood fluke of the genus Schistosoma. S. haematobium and S. mansoni are the species endemic in Egypt. The country has been plagued and seriously suffered from schistosomiasis over the past 5000 years. Great strides had been done in controlling the disease since 1922. The history, epidemiology and the different control approaches were reviewed. Currently, Egypt is preparing towards schistosomiasis elimination by 2020...
February 14, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29451887/evaluating-diagnostic-indicators-of-urogenital-schistosoma-haematobium-infection-in-young-women-a-cross-sectional-study-in-rural-south-africa
#3
Hashini Nilushika Galappaththi-Arachchige, Sigve Holmen, Artemis Koukounari, Elisabeth Kleppa, Pavitra Pillay, Motshedisi Sebitloane, Patricia Ndhlovu, Lisette van Lieshout, Birgitte Jyding Vennervald, Svein Gunnar Gundersen, Myra Taylor, Eyrun Floerecke Kjetland
BACKGROUND: Urine microscopy is the standard diagnostic method for urogenital S. haematobium infection. However, this may lead to under-diagnosis of urogenital schistosomiasis, as the disease may present itself with genital symptoms in the absence of ova in the urine. Currently there is no single reliable and affordable diagnostic method to diagnose the full spectrum of urogenital S. haematobium infection. In this study we explore the classic indicators in the diagnosis of urogenital S...
2018: PloS One
https://www.readbyqxmd.com/read/29451595/evaluation-of-molluscicidal-activity-of-three-mangrove-species-avicennia-schaueriana-laguncularia-racemosa-and-rhizophora-mangle-and-their-effects-on-the-bioactivity-of-biomphalaria-glabrata-say-1818
#4
Renato Juvino de Aragão Mendes, Adalberto Alves Pereira Filho, Aline de Jesus Lustosa Nogueira, Karla Regina Freitas Araújo, Clícia Rosane Costa França, Iramar Borba de Carvalho, Natale Maria Lindoso da Silva, Alexandre Santana Azevedo, Ivone Garros Rosa
Schistosomiasis is a disease of global extent reaching populations in social vulnerability. One of the control measures of this parasitosis is the use of molluscicidal substances that can fight snails of the genus Biomphalaria, intermediate hosts of Schistosoma mansoni. The aim of this work was to study the toxic activity of three mangrove species (Avicennia schaueriana Stapf. & Leech, ex Moldenke, 1939, Laguncularia racemosa (L.) CF Gaertn, 1807 and Rhizophora mangle L. 1753) on the biological activities of snails Biomphalaria glabrata...
2018: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29447366/parent-of-origin-dependent-gene-expression-in-male-and-female-schistosome-parasites
#5
Julien Kincaid-Smith, Marion A L Picard, Céline Cosseau, Jérôme Boissier, Dany Severac, Christoph Grunau, Eve Toulza
Schistosomes are the causative agents of schistosomiasis, a Neglected Tropical Disease affecting over 230 million people worldwide. Additionally to their major impact on human health, they are also models of choice in evolutionary biology. These parasitic flatworms are unique among the common hermaphroditic trematodes as they have separate sexes. This so-called « evolutionary scandal » displays a female heterogametic genetic sex-determination system (ZZ males and ZW females), as well as a pronounced adult sexual dimorphism...
February 12, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29432451/microexon-gene-transcriptional-profiles-and-evolution-provide-insights-into-blood-processing-by-the-schistosoma-japonicum-esophagus
#6
Xiao-Hong Li, Ricardo DeMarco, Leandro X Neves, Sally R James, Katherine Newling, Peter D Ashton, Jian-Ping Cao, R Alan Wilson, William Castro-Borges
BACKGROUND: Adult schistosomes have a well-developed alimentary tract comprising an oral sucker around the mouth, a short esophagus and a blind ending gut. The esophagus is not simply a muscular tube for conducting blood from the mouth to gut but is divided into compartments, surrounded by anterior and posterior glands, where processing of ingested blood is initiated. Self-cure of rhesus macaques from a Schistosoma japonicum infection appears to operate by blocking the secretory functions of these glands so that the worms cease feeding and slowly starve to death...
February 12, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29428201/the-use-of-gold-nanorods-as-a-new-vaccine-platform-against-schistosomiasis
#7
Natan R G Assis, Anderson J Caires, Bárbara C Figueiredo, Suellen B Morais, Fábio S Mambelli, Fábio V Marinho, Luís O Ladeira, Sergio C Oliveira
Schistosomiasis is an important parasitic disease affecting >207 million people in 76 countries around the world and causing approximately 250,000 deaths per year. At present, the main strategy adopted for the control of schistosomiasis is the use of safe chemotherapy, such as praziquantel. However, the high rates of reinfection after treatment restrict the use of this treatment approach and assume the need for other forms of control such as vaccination. Sm29 is a protein that is localized in the Schistosoma mansoni tegument of adult worms and schistosomula and is considered a powerful vaccine candidate...
February 8, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29425749/development-of-a-lateral-flow-recombinase-polymerase-assay-for-the-diagnosis-of-schistosoma-mansoni-infections
#8
Kate Poulton, Bonnie Webster
Infection with Schistosoma mansoni causes intestinal schistosomiasis, a major health problem across Africa. The accurate diagnosis of intestinal schistosomiasis is vital to inform surveillance/control programs. Diagnosis mainly relies on microscopic detection of eggs in faecal samples but many factors affect sensitivity. Molecular diagnostics are sensitive and specific but application is limited as necessary infrastructure, financial resources and skilled personnel are often lacking in endemic settings. Recombinase Polymerase Amplification (RPA) is an isothermal DNA amplification/detection technology that is practical in nearly any setting...
February 6, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29425656/in-vivo-schistosomicidal-activity-of-7-epiclusianone-and-its-quantification-in-the-plasma-of-healthy-and-schistosoma-mansoni-infected-mice-using-uplc-ms-ms
#9
Aline Pereira Castro, Taila Kawano, Lidia Emmanuela Wiazowski Spelta, Andreísa Teixeira de Castro, Neusa Araújo Pereira, Flavia Fernanda Bubula Couto, Marcelo Henrique Dos Santos, Vanessa Bergamin Boralli, Marcos José Marques
BACKGROUND: The tetraprenylated benzophenone 7-epiclusianone (7-epi) is a substance isolated from the fruits of Garcinia brasiliensis and in vitro studies have demonstrated that 7-epi is effective against Schistosoma mansoni adult worms. HYPOTHESIS/PURPOSE: Here we report the in vivo evaluation of 7-epi and its pharmacokinetic in healthy and Schistosoma mansoni infected mice. STUDY DESIGN AND METHODS: In this work, we assayed the schistosomicidal activity of 7-epi at the dose of 100 mg/kg and 300 mg/kg body weight/day in S...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29425229/schistosoma-mansoni-smki-1-serine-protease-inhibitor-binds-to-elastase-and-impairs-neutrophil-function-and-inflammation
#10
Suellen B Morais, Barbara C Figueiredo, Natan R G Assis, Debora M Alvarenga, Mariana T Q de Magalhães, Rafaela S Ferreira, Angélica T Vieira, Gustavo B Menezes, Sergio C Oliveira
Protease inhibitors have important function during homeostasis, inflammation and tissue injury. In this study, we described the role of Schistosoma mansoni SmKI-1 serine protease inhibitor in parasite development and as a molecule capable of regulating different models of inflammatory diseases. First, we determine that recombinant (r) SmKI-1 and its Kunitz domain but not the C-terminal region possess inhibitory activity against trypsin and neutrophil elastase (NE). To better understand the molecular basis of NE inhibition by SmKI-1, molecular docking studies were also conducted...
February 9, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29422423/use-of-artesunate-in-non-malarial-indications
#11
REVIEW
A Raffetin, F Bruneel, C Roussel, M Thellier, P Buffet, E Caumes, S Jauréguiberry
INTRODUCTION: Artesunate and other artemisinin derivatives are used in various infectious and non-infectious diseases. We aimed to analyze available data on artesunate and artemisinin derivatives activity in humans and their potential clinical benefits in non-malarial indications. MATERIAL AND METHODS: Literature review performed on PubMed and the Cochrane Library databases using the PRISMA method. We analyzed studies published in English from January 2008 to August 2017 using the same indicators of drug efficacy...
February 5, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29415040/the-role-of-family-size-employment-and-education-of-parents-in-the-prevalence-of-intestinal-parasitic-infections-in-school-children-in-accra
#12
Akua Obeng Forson, Isaac Arthur, Patrick F Ayeh-Kumi
INTRODUCTION: Intestinal parasitic infections (IPIs) in school children are a public health problem in most developing countries. METHODS AND PRINCIPAL FINDINGS: A cross sectional survey was conducted from May to July 2016 with school children living in overcrowded urban slums in Accra, Ghana. A simple random sample of 300 children aged 2-9 years was collected. The study used structured pre-tested questionnaire and stool tests to obtain information on epidemiological, sanitation habits, employment and education status of parents and children...
2018: PloS One
https://www.readbyqxmd.com/read/29414671/fibrinogen-and-fibrin-are-novel-substrates-for-fasciola-hepatica-cathepsin-l-peptidases
#13
Mirjam M Mebius, Jody M J Op Heij, Aloysius G M Tielens, Philip G de Groot, Rolf T Urbanus, Jaap J van Hellemond
Cathepsin peptidases form a major component of the secreted proteins of the blood-feeding trematodes Fasciola hepatica and Schistosoma mansoni. These peptidases fulfill many functions, from facilitating infection to feeding and immune evasion. In this study, we examined the Fasciola cathepsin L peptidases FhCL1, FhCL2, and FhCL3 and the schistosomal cathepsin peptidases SmCB1 and SmCL3 for their anticoagulant properties. Although no direct anticoagulant effect of these peptidases was observed, we discovered that cathepsin peptidases from Fasciola, but not from Schistosoma, were able to degrade purified fibrinogen, with FhCL1 having the highest fibrinogenolytic activity...
February 4, 2018: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/29413983/evaluation-of-a-novel-micro-sampling-device-mitra%C3%A2-in-comparison-to-dried-blood-spots-for-analysis-of-praziquantel-in-schistosoma-haematobium-infected-children-in-rural-c%C3%A3-te-d-ivoire
#14
Jana Kovač, Gordana Panic, Anna Neodo, Isabel Meister, Jean T Coulibaly, Jessica D Schulz, Jennifer Keiser
Pharmacokinetic (PK) studies with paediatric populations are increasing in importance for drug development. However, conventional PK sampling methods are characterised by invasiveness and low patient adherence, unsuitable for use with sensitive population, such as children. Mitra™ is a novel volumetric absorptive micro-sampling device, which offers an alternative to the dried blood spotting (DBS) technique, a current popular sampling technique within PK studies. We tested Mitra™ for the first time in the framework of a randomised controlled trial in rural Côte d'Ivoire...
January 26, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29411605/investigation-of-agonist-recognition-and-channel-properties-in-a-flatworm-glutamate-gated-chloride-channel
#15
Daniel Callau-Vázquez, Stephan A Pless, Timothy Lynagh
Glutamate-gated chloride channels (GluCls) are neurotransmitter receptors that mediate crucial inhibitory signaling in invertebrate neuromuscular systems. Their role in invertebrate physiology and their absence from vertebrates make GluCls a prime target for antiparasitic drugs. GluCls from flatworm parasites are substantially different from and are much less understood than those from roundworm and insect parasites, hindering the development of potential therapeutics targeting GluCls in flatworm-related diseases such as schistosomiasis...
February 7, 2018: Biochemistry
https://www.readbyqxmd.com/read/29409939/a-new-soluble-and-bioactive-polymorph-of-praziquantel
#16
Debora Zanolla, Beatrice Perissutti, Nadia Passerini, Michele R Chierotti, Dritan Hasa, Dario Voinovich, Lara Gigli, Nicola Demitri, Silvano Geremia, Jennifer Keiser, Paolo Cerreia Vioglio, Beatrice Albertini
Praziquantel is the only available drug to treat Schistosomiasis. However, its utilization is limited by many drawbacks, including the high therapeutic dose needed, resulting in large tablets and capsules difficult to be swallowed, especially from pediatric patients. In this study, an alternative option to overcome these disadvantages is proposed: to switch to a novel crystalline polymorph of racemic compound praziquantel. The preparation of the crystalline polymorph was realized via a neat grinding process in a vibrational mill...
January 30, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29409884/identification-of-toll-like-receptor-family-members-in-oncomelania-hupensis-and-their-role-in-defense-against-schistosoma-japonicum
#17
Qin Ping Zhao, Qian Gao, Yan Zhang, Yan Wei Li, Wen Ling Huang, Chun-Lian Tang, Hui Fen Dong
The amphibious snail, Oncomelania hupensis, primarily distributed in the Far East, is the only intermediate host of Schistosoma japonicum, which causes the most virulent form of schistosomiasis. Obligatory parasitism of snails is the main vehicle for human and livestock infection and depends primarily on parasite infectivity, snail defense capacity and specificity, and parasite-snail compatibility. Therefore, the schistosome-snail interaction is biomedically significant, particularly the molecular mechanisms involved in the innate immune response against S...
January 30, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29409536/pharmacological-and-immunological-effects-of-praziquantel-against-schistosoma-japonicum-a-scoping-review-of-experimental-studies
#18
REVIEW
Shu-Hua Xiao, Jun Sun, Ming-Gang Chen
BACKGROUND: Chemotherapy for schistosomiasis has been around for 100 years. During the past century, great efforts have been made to develop new antischistosomal drugs from antimonials to nonantimonials, and some of these have been used extensively in clinical treatment. With the exception of a few drugs, such as oxamniquine and metrifonate, most of the antischistosomals developed in the pre-praziquantel period have variable limitations with respect to safety and efficacy. Although oxamniquine and metrifonate have been used for schistosomiasis control, they are only effective against Schistosoma mansoni and S...
February 7, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29405114/decreased-sensitivity-of-schistosoma-sp-egg-microscopy-in-women-and-hiv-infected-individuals
#19
Soledad Colombe, Myung Hee Lee, Peter J Masikini, Lisette van Lieshout, Claudia J de Dood, Pytsje T Hoekstra, Paul L A M Corstjens, Julius Mngara, Govert J van Dam, Jennifer A Downs
It has been postulated that impaired host immunity due to HIV infection reduces parasite egg excretion. Schistosoma/HIV interactions have also been shown to differ by sex. We hypothesized that egg excretion would vary based on both HIV status and sex. We examined data from more than 1,700 participants in eight studies conducted in northwest Tanzania between 2010 and 2016. Schistosoma infection was defined by circulating anodic antigen (CAA) serum levels ≥ 30 pg/mL and/or egg positivity in either stool by Kato Katz method or urine by filtration...
February 5, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29405110/mapping-out-the-under-recognized-burden-of-human-infertility-linked-to-schistosoma-haematobium-infection
#20
Charles H King
In an article1 published in this month's issue of the American Journal of Tropical Medicine and Hygiene, Patricia Woodall and Michael Kramer report on the ecological association between long-term exposure to Schistosoma infection and a woman's odds of experiencing primary or secondary infertility in four East African countries-Ethiopia, Kenya, Tanzania, and Uganda. Links between schistosomiasis, (particularly urogenital schistosomiasis caused by Schistosoma haematobium) and either primary or secondary infertility have long been suspected based on past case reports2,3 and on limited cross-sectional community studies...
February 5, 2018: American Journal of Tropical Medicine and Hygiene
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