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https://www.readbyqxmd.com/read/28231240/galectin-3-histone-deacetylases-and-hedgehog-signaling-possible-convergent-targets-in-schistosomiasis-induced-liver-fibrosis
#1
REVIEW
Felipe Leite de Oliveira, Katia Carneiro, José Marques Brito, Mariana Cabanel, Jonathas Xavier Pereira, Ligia de Almeida Paiva, Wingkin Syn, Neil C Henderson, Marcia Cury El-Cheikh
Schistosomiasis affects approximately 240 million people in the world. Schistosoma mansoni eggs in the liver induce periportal fibrosis and hepatic failure driven by monocyte recruitment and macrophage activation, resulting in robust Th2 response. Here, we suggested a possible involvement of Galectin-3 (Gal-3), histone deacetylases (HDACs), and Hedgehog (Hh) signaling with macrophage activation during Th1/Th2 immune responses, fibrogranuloma reaction, and tissue repair during schistosomiasis. Gal-3 is highly expressed by liver macrophages (Kupffer cells) around Schistosoma eggs...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28222680/field-evaluation-of-a-recombinase-polymerase-amplification-assay-for-the-diagnosis-of-schistosoma-japonicum-infection-in-hunan-province-of-china
#2
Weiwei Xing, Xinling Yu, Jingtao Feng, Kui Sun, Wenliang Fu, Yuanyuan Wang, Minji Zou, Wenrong Xia, Zhihong Luo, Hongbin He, Yuesheng Li, Donggang Xu
BACKGROUND: Current diagnostic methods for Schistosoma japonicum infection are insensitive for low-density infections. Therefore, a new diagnostic assay based on recombinase polymerase amplification (RPA) technology was established and assessed for field applification. METHODS: The S.japonicum RPA assay was developed to target highly repetitive retrotransposon SjR2 gene of S japonicum, and its sensitivity and specificity were assessed by serial dilution of S. japonicum genomic DNA and other related worm genomic DNA respectively...
February 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28222149/ultrasonographic-evaluation-of-urinary-tract-morbidity-in-school-aged-and-preschool-aged-children-infected-with-schistosoma-haematobium-and-its-evolution-after-praziquantel-treatment-a-randomized-controlled-trial
#3
Beatrice Barda, Jean T Coulibaly, Christoph Hatz, Jennifer Keiser
BACKGROUND: Schistosoma haematobium infections are responsible for significant urinary tract (UT) complications. Schistosomiasis control programs aim to reduce morbidity, yet the extent of morbidity in preschool-aged children and the impact of treatment on morbidity reduction are not well studied. METHODOLOGY: Our study was embedded in a randomized, placebo-controlled, single-blind trial in Côte d'Ivoire, which evaluated the efficacy and safety of three doses (20, 40 and 60 mg/kg) of praziquantel in school-aged (SAC) and preschool-aged (PSAC) children infected with S...
February 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28219412/moving-from-control-to-elimination-of-schistosomiasis-in-sub-saharan-africa-time-to-change-and-adapt-strategies
#4
REVIEW
Louis-Albert Tchuem Tchuenté, David Rollinson, J Russell Stothard, David Molyneux
Schistosomiasis is a water borne parasitic disease of global importance and with ongoing control the disease endemic landscape is changing. In sub-Saharan Africa, for example, the landscape is becoming ever more heterogeneous as there are several species of Schistosoma that respond in different ways to ongoing preventive chemotherapy and the inter-sectoral interventions currently applied. The major focus of preventive chemotherapy is delivery of praziquantel by mass drug administration to those shown to be, or presumed to be, at-risk of infection and disease...
February 20, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28219411/using-the-hierarchical-ordinal-regression-model-to-analyse-the-intensity-of-urinary-schistosomiasis-infection-in-school-children-in-lusaka-province-zambia
#5
Christopher Simoonga, Lawrence N Kazembe
BACKGROUND: Urinary schistosomiasis has been a major public health problem in Zambia for many years. However, the disease profile may vary in different locale due to the changing ecosystem that contributes to the risk of acquiring the disease. The objective of this study was to quantify risk factors associated with the intensity of urinary schistosomiasis infection in school children in Lusaka Province, Zambia, in order to better understand local transmission. METHODS: Data were obtained from 1 912 school children, in 20 communities, in the districts of Luangwa and Kafue in Lusaka Province...
February 21, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28215207/detecting-hybridization-in-african-schistosome-species-does-egg-morphology-complement-molecular-species-identification
#6
Nele A M Boon, Wouter Fannes, Sara Rombouts, Katja Polman, Filip A M Volckaert, Tine Huyse
Hybrid parasites may have an increased transmission potential and higher virulence compared to their parental species. Consequently, hybrid detection is critical for disease control. Previous crossing experiments showed that hybrid schistosome eggs have distinct morphotypes. We therefore compared the performance of egg morphology with molecular markers with regard to detecting hybridization in schistosomes. We studied the morphology of 303 terminal-spined eggs, originating from 19 individuals inhabiting a hybrid zone with natural crosses between the human parasite Schistosoma haematobium and the livestock parasite Schistosoma bovis in Senegal...
February 20, 2017: Parasitology
https://www.readbyqxmd.com/read/28212676/genetic-diversity-and-selection-of-three-nuclear-genes-in-schistosoma-japonicum-populations
#7
Yaqi Li, Mingbo Yin, Qunfeng Wu, Donald P McManus, David Blair, Hongyan Li, Bin Xu, Xiaojin Mo, Zheng Feng, Wei Hu
BACKGROUND: The blood fluke, Schistosoma japonicum still causes severe disease in China, the Philippines and Indonesia. Although there have been some studies the molecular epidemiology of this persistent and harmful parasite, few have explored the possibility and implications of selection in S. japonicum populations. METHODS: We analyzed diversity and looked for evidence of selection at three nuclear genes (SjIpp2, SjFabp and SjT22.6) in 13 S. japonicum populations...
February 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28212670/characterization-of-schistosoma-japonicum-cp1412-protein-as-a-novel-member-of-the-ribonuclease-t2-molecule-family-with-immune-regulatory-function
#8
Xue-Dan Ke, Shuang Shen, Li-Jun Song, Chuan-Xin Yu, Mihoko Kikuchi, Kenji Hirayama, Hong Gao, Jie Wang, Xuren Yin, Yuan Yao, Qian Liu, Wei Zhou
BACKGROUND: Schistosome infection typically induces a polarized Th2 type host immune response. As egg antigen molecules play key roles in this immunoregulatory process, clarifying their functions in schistosomiasis would facilitate the development of vaccine and immunotherapeutic methods. Schistosoma japonicum (Sj) CP1412 (GenBank: AY57074.1) has been identified as a new member of the RNase T2 family with immune regulatory functions. METHODS: The expression plasmid Sj CP1412-pET28a was constructed and transformed into bacteria for production of recombinant Sj CP1412 protein (rSj CP1412) via IPTG induction...
February 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28212414/decline-in-infection-related-morbidities-following-drug-mediated-reductions-in-the-intensity-of-schistosoma-infection-a-systematic-review-and-meta-analysis
#9
Gisele Andrade, David J Bertsch, Andrea Gazzinelli, Charles H King
BACKGROUND: Since 1984, WHO has endorsed drug treatment to reduce Schistosoma infection and its consequent morbidity. Cross-sectional studies suggest pre-treatment correlation between infection intensity and risk for Schistosoma-related pathology. However, evidence also suggests that post-treatment reduction in intensity may not reverse morbidity because some morbidities occur at all levels of infection, and some reflect permanent tissue damage. The aim of this project was to systematically review evidence on drug-based control of schistosomiasis and to develop a quantitative estimate of the impact of post-treatment reductions in infection intensity on prevalence of infection-associated morbidity...
February 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28211535/arylmethylamino-steroids-as-antiparasitic-agents
#10
Reimar Krieg, Esther Jortzik, Alice-Anne Goetz, Stéphanie Blandin, Sergio Wittlin, Mourad Elhabiri, Mahsa Rahbari, Selbi Nuryyeva, Kerstin Voigt, Hans-Martin Dahse, Axel Brakhage, Svenja Beckmann, Thomas Quack, Christoph G Grevelding, Anthony B Pinkerton, Bruno Schönecker, Jeremy Burrows, Elisabeth Davioud-Charvet, Stefan Rahlfs, Katja Becker
In search of antiparasitic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than 60 derivatives. The lead compound 1o is fast acting and highly active against intraerythrocytic stages of chloroquine-sensitive and resistant Plasmodium falciparum parasites (IC50 1-5 nM) as well as against gametocytes. In P. berghei-infected mice, oral administration of 1o drastically reduces parasitaemia and cures the animals. Furthermore, 1o efficiently blocks parasite transmission from mice to mosquitoes...
February 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28204958/biological-control-of-snail-hosts-transmitting-schistosomiasis-by-the-water-bug-sphaerodema-urinator
#11
Aly Younes, Hanaa El-Sherief, Fathia Gawish, Marwa Mahmoud
The water bug, Sphaerodema urinator (Hemiptera : Belostomatidae), shares the same habitat of the freshwater snails in ponds, lakes, and streams. Studies conducted in lakes show that fish and crayfish predators play an important role in determining the abundance of freshwater snails. In contrast, shallow ponds and marches often lack fish and crayfish but have abundant insect predators. This study has been carried out to evaluate the predatory potential of S. urinator adult on two freshwater snails that serves as intermediate hosts of Schistosoma...
February 15, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28201853/antigenic-cross-reactivity-between-schistosoma-mansoni-and-peanut-a-role-for-cross-reactive-carbohydrate-determinants-ccds-and-implications-for-the-hygiene-hypothesis
#12
Joseph E Igetei, Marwa El-Faham, Susan Liddell, Michael J Doenhoff
The antigenic reactivity of constituents of Schistosoma mansoni and peanut (Arachis hypogaea) was investigated to determine whether identical antigenic epitopes possessed by both organisms provided a possible explanation for the negative correlation between chronic schistosome infection and atopy to allergens. Aqueous extracts of peanuts were probed in Western immunoblots with rabbit IgG antibodies raised against the egg, cercarial and adult worm stages of S. mansoni. Several molecules in the peanut extract were antigenically reactive with antibodies from the various rabbit anti-schistosome sera...
February 15, 2017: Immunology
https://www.readbyqxmd.com/read/28196636/impact-of-schistosomiasis-on-increase-incidence-of-occult-hepatitis-b-in-chronic-hepatitis-c-patients-in-egypt
#13
Hanan H Omar, Samaa A Taha, Wafaa H Hassan, Hamdy H Omar
Co-infection of schistosomiasis, HBV and HCV is common in countries where schistosomiasis is endemic. Occult hepatitis B occurs in patients at high risk for HBV infection (e.g., patients on hemodialysis, patients receiving blood transfusions). Schistosomal infection is a risk factor of HBV infection that can increase the incidence of occult hepatitis B. We aimed to determine the prevalence of occult hepatitis B in chronic hepatitis C patients with and without schistosomiasis and to assess the effect of schistosomal infection on the increased risk of exposure to HBV infection and to occult hepatitis B...
February 9, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28192534/sm-p80-based-schistosomiasis-vaccine-mediated-epistatic-interactions-identified-potential-immune-signatures-for-vaccine-efficacy-in-mice-and-baboons
#14
Juan U Rojo, Michael W Melkus, Kameswara Rao Kottapalli, Oscar E Okiya, Justin Sudduth, Weidong Zhang, Adebayo J Molehin, Darrick Carter, Afzal A Siddiqui
Schistosomiasis is a neglected parasitic disease of major public health concern as it affects over 250 million people in developing countries. Currently there is no licensed vaccine available against schistosomiasis. The Schistosoma mansoni calpain protein, Sm-p80, is a leading vaccine candidate now ready to move to clinical trials. In order to better assess Sm-p80 vaccine immunogenicity; here we used a systems biology approach employing RNA-sequencing to identify gene signatures and epistatic interactions following Sm-p80 vaccination in mouse and baboon models that may predict vaccine efficacy...
2017: PloS One
https://www.readbyqxmd.com/read/28192437/species-dependent-impact-of-helminth-derived-antigens-on-human-macrophages-infected-with-mycobacterium-tuberculosis-direct-effect-on-the-innate-anti-mycobacterial-response
#15
Naomi Aira, Anna-Maria Andersson, Susmita K Singh, Derek M McKay, Robert Blomgran
BACKGROUND: In countries with a high prevalence of tuberculosis there is high coincident of helminth infections that might worsen disease outcome. While Mycobacterium tuberculosis (Mtb) gives rise to a pro-inflammatory Th1 response, a Th2 response is typical of helminth infections. A strong Th2 response has been associated with decreased protection against tuberculosis. PRINCIPAL FINDINGS: We investigated the direct effect of helminth-derived antigens on human macrophages, hypothesizing that helminths would render macrophages less capable of controlling Mtb...
February 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28185924/high-throughput-dynamic-analysis-of-differentially-expressed-genes-in-splenic-dendritic-cells-from-mice-infected-with-schistosoma-japonicum
#16
Lin Chen, Qingzhou Chen, Wei Hou, Li He
Dendritic cells are the initiation and key point of immune response and play a role in immune regulation. So we explored the mechanisms involved in immune regulation of dendritic cells (DCs) against schistosomiasis using mice infected with Schistosoma japonicum. Splenic DCs from normal mice and mice with acute and chronic S. japonicum infection were sorted by flow cytometry. The numbers and functions of differentially expressed genes (DEGs) in DCs were determined by high-throughput analysis. All DEGs with transcription-level fold changes of ≥2 were selected and matched to corresponding genes in databases...
February 7, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28185084/-schistosomose-urog%C3%A3-nitale-et-cancer
#17
A Berry, X Iriart, J Fillaux, J-F Magnaval
The existence of a link between urinary schistosomiasis (US) and bladder carcinoma was first suspected by C. Goebel in 1905. In 1911, A.R Ferguson, who was a professor of Pathology and Microbiology at the Faculty of Medicine in Cairo, published a more detailed survey from 40 autopsies, and reported a likely association of bladder carcinoma with granulomas caused by US. Subsequently, published results from several studies reinforced Ferguson's hypothesis. Moreover, in most countries where US was endemic, association of high prevalence of bladder carcinoma with US had been pointed out...
February 10, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28185057/the-dynamic-changes-of-cd3e-cd11c-dendritic-cells-in-spleens-and-bone-marrow-of-mice-infected-with-schistosoma-japonicum
#18
Lin Chen, Qingzhou Chen, Wei Hou, Li He
Schistosoma japonicum as a pathogeny requires dendritic cells to activate immune response. So, the research is to study the dynamic changes of CD3e(-)CD11c(+) dendritic cells in mice infected with S. japonicum. Zero, 7, 28, 35, and 63 days were selected to study the variation of dendritic cells, and the proportions of CD3e(-)CD11c(+) dendritic cells and CD86(+) mature dendritic cells in spleens and bone marrow were tested by flow cytometry. As a result, the variation trends of dendritic cells in spleen and bone marrow are similar as follows: the proportions of CD3e(-)CD11c(+) dendritic cells increased first and then decreased from day 35, but the percentages of CD86(+) mature dendritic cells decreased from day 28 and increased in day 63...
February 10, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28178325/prevalence-and-clinical-relevance-of-helminth-co-infections-among-tuberculosis-patients-in-urban-tanzania
#19
Francis Mhimbira, Jerry Hella, Khadija Said, Lujeko Kamwela, Mohamed Sasamalo, Thomas Maroa, Magreth Chiryamkubi, Grace Mhalu, Christian Schindler, Klaus Reither, Stefanie Knopp, Jürg Utzinger, Sébastien Gagneux, Lukas Fenner
BACKGROUND: Helminth infections can negatively affect the immunologic host control, which may increase the risk of progression from latent Mycobacterium tuberculosis infection to tuberculosis (TB) disease and alter the clinical presentation of TB. We assessed the prevalence and determined the clinical relevance of helminth co-infection among TB patients and household contact controls in urban Tanzania. METHODOLOGY: Between November 2013 and October 2015, we enrolled adult (≥18 years) sputum smear-positive TB patients and household contact controls without TB during an ongoing TB cohort study in Dar es Salaam, Tanzania...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28178298/the-impact-of-prenatal-exposure-to-parasitic-infections-and-to-anthelminthic-treatment-on-antibody-responses-to-routine-immunisations-given-in-infancy-secondary-analysis-of-a-randomised-controlled-trial
#20
Stephen Nash, Alexander J Mentzer, Swaib A Lule, Dennison Kizito, Gaby Smits, Fiona R M van der Klis, Alison M Elliott
BACKGROUND: Chronic parasitic infections are associated with active immunomodulation which may include by-stander effects on unrelated antigens. It has been suggested that pre-natal exposure to parasitic infections in the mother impacts immunological development in the fetus and hence the offspring's response to vaccines, and that control of parasitic infection among pregnant women will therefore be beneficial. METHODOLOGY/PRINCIPAL FINDINGS: We used new data from the Entebbe Mother and Baby Study, a trial of anthelminthic treatment during pregnancy conducted in Uganda, to further investigate this hypothesis...
February 2017: PLoS Neglected Tropical Diseases
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