keyword
MENU ▼
Read by QxMD icon Read
search

micromachines

keyword
https://www.readbyqxmd.com/read/29203440/car-t-cells-and-combination-therapies-what-s-next-in-the-immunotherapy-revolution
#1
Maria C Ramello, Eric B Haura, Daniel Abate-Daga
Cancer immunotherapies are dramatically reshaping the clinical management of oncologic patients. For many of these therapies, the guidelines for administration, monitoring, and management of associated toxicities are still being established. This is especially relevant for adoptively transferred, genetically-modified T cells, which have unique pharmacokinetic properties, due to their ability to replicate and persist long-term, following a single administration. Furthermore, in the case of CAR-T cells, the use of synthetic immune receptors may impact signaling pathways involved in T cell function and survival in unexpected ways...
December 1, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29182317/the-twists-and-turns-of-orbiting-and-spinning-metallic-microparticles-powered-by-megahertz-ultrasound
#2
Chao Zhou, Leilei Zhao, Mengshi Wei, Wei Wang
Micromotors powered by megahertz ultrasound, first reported about 5 years ago, have lately been considered a promising platform for a wide range of microscale applications, yet we are only at the early stage of understanding their operating mechanisms. Through carefully designed experiments, and by comparing the results to acoustic theories, we present here an in-depth study of the behaviors of particles activated by ultrasound, especially their in-plane orbiting and spinning dynamics. Experiments suggest that metallic micro-rods orbit in tight circles near the resonance ultrasound frequency, likely driven by localized acoustic streaming due to slightly bent particle shapes...
November 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/29154314/feasibility-and-its-characteristics-of-co2-laser-micromachining-based-pmma-anti-scattering-grid-estimated-by-mcnp-code-simulation
#3
Jun Woo Bae, Hee Reyoung Kim
BACKGROUND: Anti-scattering grid has been used to improve the image quality. However, applying a commonly used linear or parallel grid would cause image distortion, and focusing grid also requires a precise fabrication technology, which is expensive. OBJECTIVE: To investigate and analyze whether using CO2 laser micromachining-based PMMA anti-scattering grid can improve the performance of the grid at a lower cost. Thus, improvement of grid performance would result in improvement of image quality...
November 16, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/29127280/electrostrictive-microelectromechanical-fibres-and-textiles
#4
Tural Khudiyev, Jefferson Clayton, Etgar Levy, Noémie Chocat, Alexander Gumennik, Alexander M Stolyarov, John Joannopoulos, Yoel Fink
Microelectromechanical systems (MEMS) enable many modern-day technologies, including actuators, motion sensors, drug delivery systems, projection displays, etc. Currently, MEMS fabrication techniques are primarily based on silicon micromachining processes, resulting in rigid and low aspect ratio structures. In this study, we report on the discovery of MEMS functionality in fibres, thereby opening a path towards flexible, high-aspect ratio, and textile MEMS. The method used for generating these MEMS fibres leverages a preform-to-fibre thermal drawing process, in which the MEMS architecture and materials are embedded into a preform and drawn into kilometers of microstructured multimaterial fibre devices...
November 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/29122711/developmental-refinement-of-synaptic-transmission-on-micropatterned-single-layer-graphene
#5
Sandeep Keshavan, Shovan Naskar, Alberto Diaspro, Laura Cancedda, Silvia Dante
Interfacing neurons with a single atomic layer of graphene, single atomic layer of sp2 hybridized C-atoms, is a key paradigm in understanding how to exploit the unique properties of such a two-dimensional system for neural prosthetics and biosensors development. In order to fabricate graphene-based circuitry, a reliable large area patterning method is a requirement. Following a previously developed protocol, we monitored the in vitro neuronal development of geometrically ordered neural network growing onto patterned Single Layer Graphene (SLG) coated with poly-D-lysine...
November 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29047533/development-of-a-multi-band-photoacoustic-tomography-imaging-system-based-on-a-capacitive-micromachined-ultrasonic-transducer-array
#6
Jian Zhang, Sio Hang Pun, Yuanyu Yu, Duyang Gao, Jiujiang Wang, Peng Un Mak, Kin Fong Lei, Ching-Hsiang Cheng, Zhen Yuan
Photoacoustic tomography (PAT) as a hybrid technology combines the high optical contrast and high acoustic resolution in a single imaging modality. However, most of the available PAT systems cannot comprehensively or accurately characterize biological systems at multiple length scales due to the use of narrow bandwidth commercial ultrasonic transducers. In this study, we fabricated a novel multi-band capacitive micromachined ultrasonic transducer (CMUT) array, and first developed a CMUT-based multi-band photoacoustic tomography (MBPAT) imaging system...
May 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29034168/quantitative-comparison-of-pzt-and-cmut-probes-for-photoacoustic-imaging-experimental-validation
#7
Maëva Vallet, François Varray, Jérôme Boutet, Jean-Marc Dinten, Giosuè Caliano, Alessandro Stuart Savoia, Didier Vray
Photoacoustic (PA) signals are short ultrasound (US) pulses typically characterized by a single-cycle shape, often referred to as N-shape. The spectral content of such wideband signals ranges from a few hundred kilohertz to several tens of megahertz. Typical reception frequency responses of classical piezoelectric US imaging transducers, based on PZT technology, are not sufficiently broadband to fully preserve the entire information contained in PA signals, which are then filtered, thus limiting PA imaging performance...
December 2017: Photoacoustics
https://www.readbyqxmd.com/read/29019249/electrochemical-atr-seiras-using-low-cost-micromachined-si-wafers
#8
Tyler A Morhart, Bipinlal Unni, Michael J Lardner, Ian J Burgess
Thin, micromachined Si wafers, designed as internal reflection elements (IREs) for attenuated total reflectance infrared spectroscopy, are adapted to serve as substrates for electrochemical ATR surface enhanced infrared absorption spectroscopy (ATR-SEIRAS). The 500 μm thick wafer IREs with groove angles of 35° are significantly more transparent at long mid-IR wavelengths as compared to conventional large Si hemisphere IREs. The appeal of greater transparency is mitigated by smaller optical throughput at larger grazing angles and steeper angles of incidence at the reflecting plane that reduce the enhancement factor...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29017900/neural-electrode-resilience-against-dielectric-damage-may-be-improved-by-use-of-highly-doped-silicon-as-a-conductive-material
#9
Ryan Caldwell, Rohit Sharma, Pavel Takmakov, Matthew G Street, Florian Solzbacher, Prashant Tathireddy, Loren Rieth
BACKGROUND: Dielectric damage occurring in vivo to neural electrodes, leading to conductive material exposure and impedance reduction over time, limits the functional lifetime and clinical viability of neuroprosthetics. We used silicon micromachined Utah Electrode Arrays (UEAs) with iridium oxide (IrOx) tip metallization and parylene C dielectric encapsulation to understand the factors affecting device resilience and drive improvements. NEW METHOD: In vitro impedance measurements and finite element analyses were conducted to evaluate how exposed surface area of silicon and IrOx affect UEA properties...
October 7, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28994803/an-experimental-protocol-for-assessing-the-performance-of-new-ultrasound-probes-based-on-cmut-technology-in-application-to-brain-imaging
#10
Giulia Matrone, Alessandro Ramalli, Alessandro Stuart Savoia, Fabio Quaglia, Gloria Castellazzi, Patrizia Morbini, Marco Piastra
The possibility to perform an early and repeatable assessment of imaging performance is fundamental in the design and development process of new ultrasound (US) probes. Particularly, a more realistic analysis with application-specific imaging targets can be extremely valuable to assess the expected performance of US probes in their potential clinical field of application. The experimental protocol presented in this work was purposely designed to provide an application-specific assessment procedure for newly-developed US probe prototypes based on Capacitive Micromachined Ultrasonic Transducer (CMUT) technology in relation to brain imaging...
September 24, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28994800/fabrication-and-validation-of-an-organ-on-chip-system-with-integrated-electrodes-to-directly-quantify-transendothelial-electrical-resistance
#11
Marinke W van der Helm, Mathieu Odijk, Jean-Philippe Frimat, Andries D van der Meer, Jan C T Eijkel, Albert van den Berg, Loes I Segerink
Organs-on-chips, in vitro models involving the culture of (human) tissues inside microfluidic devices, are rapidly emerging and promise to provide useful research tools for studying human health and disease. To characterize the barrier function of cell layers cultured inside organ-on-chip devices, often transendothelial or transepithelial electrical resistance (TEER) is measured. To this end, electrodes are usually integrated into the chip by micromachining methods to provide more stable measurements than is achieved with manual insertion of electrodes into the inlets of the chip...
September 26, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28994785/aerosol-assisted-chemical-vapor-deposition-of-metal-oxide-structures-zinc-oxide-rods
#12
Stella Vallejos, Nade Z da Pizu Rova, Jan Čechal, Isabel Gràcia, Carles Cané
Whilst columnar zinc oxide (ZnO) structures in the form of rods or wires have been synthesized previously by different liquid- or vapor-phase routes, their high cost production and/or incompatibility with microfabrication technologies, due to the use of pre-deposited catalyst-seeds and/or high processing temperatures exceeding 900 °C, represent a drawback for a widespread use of these methods. Here, however, we report the synthesis of ZnO rods via a non-catalyzed vapor-solid mechanism enabled by using an aerosol-assisted chemical vapor deposition (CVD) method at 400 °C with zinc chloride (ZnCl2) as the precursor and ethanol as the carrier solvent...
September 14, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28960218/3d-shape-evolution-of-microparticles-and-3d-enabled-applications-using-non-uniform-uv-flow-lithography-nufl
#13
Kenneth Choi, Mohammad Salehizadeh, Rafael Belo Da Silva, Navid Hakimi, Eric Diller, Dae Kun Hwang
The generation of microparticles with non-spherical morphologies has generated extensive interest because of their enhanced physical properties that can increase their performance in a wide variety of clinical and industrial applications. A flow lithographic technique based on stop flow lithography (SFL) recently showed the ability to fabricate particles with 3D shapes via manipulation of the UV intensity profile in a simple 2D microfluidic channel. Here, we further explore this flow lithographic method, called non-uniform flow lithography (NUFL), to investigate the 3D-shape tuning ability for the generation of 3D magnetic microparticles and their potential applications...
October 18, 2017: Soft Matter
https://www.readbyqxmd.com/read/28957259/micro-cantilever-based-fiber-optic-hydrophone-fabricated-by-a-femtosecond-laser
#14
Jie Liu, Lei Yuan, Jincheng Lei, Wenge Zhu, Baokai Cheng, Qi Zhang, Yang Song, Chuan Chen, Hai Xiao
We report an open cavity, cantilever-based fiber optic Fabry-Perot interferometer hydrophone. The hydrophone is made of fused silica material, and its micro-cantilever beam is directly fabricated by femtosecond (fs) laser micromachining. The theoretical analyses and experimental verifications of the frequency response of the sensor are presented.
July 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28930146/co%C3%A2-sensing-characteristics-of-a-la%C3%A2-o%C3%A2-sno%C3%A2-stacked-structure-with-micromachined-hotplates
#15
Tatsuya Iwata, Kyosuke Matsuda, Kazuhiro Takahashi, Kazuaki Sawada
Demand for the detection of carbon dioxide (CO 2 ) is increasing in various fields, including air-quality monitoring, healthcare, and agriculture. On the other hand, smart gas sensors, in which micromachined gas sensors are integrated with driving circuits, are desirable toward the development of the society of the internet of things. In this study, micromachined hotplate-based CO 2 sensors were fabricated and their characteristics were investigated. The sensors have La 2 O 3 /SnO 2 stacked layers as a sensing material and Pt interdigitated electrodes...
September 20, 2017: Sensors
https://www.readbyqxmd.com/read/28929363/all-in-one-low-intensity-pulsed-ultrasound-stimulation-system-using-piezoelectric-micromachined-ultrasonic-transducer-pmut-arrays-for-targeted-cell-stimulation
#16
Wonjun Lee, Seungjun Yoo, Joontaek Jung, Woojin Kang, Wei Wang, Cheil Moon, Hongsoo Choi
A novel cell-stimulation system was fabricated using 10 × 29 piezoelectric micromachined ultrasonic transducer (pMUT) arrays for targeted ultrasonic cell stimulation. Both the diameter of a single pMUT element and the edge-to-edge gap were 120 μm, and the size of a pMUT array was 2.27 × 6.84 mm, to be placed at the bottom of a Transwell. The measured resonance frequency of a single pMUT element was 1.48 ± 0.13 MHz and the measured acoustic intensity of the pMUT array was 0.15 ± 0.03 MPa at 1 mm away from the transducer...
September 19, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28900104/geometrically-controlled-polarisation-processing-in-femtosecond-laser-written-photonic-circuits
#17
Ioannis Pitsios, Farid Samara, Giacomo Corrielli, Andrea Crespi, Roberto Osellame
Polarisation of light is a powerful and widely used degree of freedom to encode information, both in classical and quantum applications. In particular, quantum information technologies based on photons are being revolutionised by the use of integrated photonic circuits. It is therefore very important to be able to manipulate the polarisation of photons in such circuits. We experimentally demonstrate the fabrication by femtosecond laser micromachining of components such as polarisation insensitive and polarising directional couplers, operating at 1550 nm wavelength, where the two opposite behaviours are achieved just by controlling the geometric layout of the photonic circuits, being the waveguides fabricated with the same irradiation recipe...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28844120/development-of-a-biodegradable-flow-resisting-polymer-membrane-for-a-novel-glaucoma-microstent
#18
Stefan Siewert, Karen Falke, Frank Luderer, Thomas Reske, Wolfram Schmidt, Sylvia Pfensig, Michael Stiehm, Ulf Hinze, Boris Chichkov, Niels Grabow, Rudolf Guthoff, Klaus-Peter Schmitz
Within this paper we analyzed the technical feasibility of a novel microstent for glaucoma therapy. For lowering of intraocular pressure, the flexible polyurethane (PUR) implant is designed to drain aqueous humour from the anterior chamber of the eye into subconjunctival, or alternatively suprachoroidal, space. The microstent includes a biodegradable, flow resisting polymer membrane serving as temporary flow resistance for the prevention of early postoperative hypotony. A biodegradable local drug delivery (LDD)-device was designed to prevent fibrous encapsulation...
August 26, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28831196/assembly-of-a-functional-and-responsive-microstructure-by-heat-bonding-of-dna-grafted-colloidal-brick
#19
Yuki Sakamoto, Shoichi Toyabe
A micromachine constructed to possess various chemical and mechanical functions is one of the ultimate targets of technology. Conventional lithographic processes can be used to form complicated structures. However, they are basically limited to rigid and static structures with poor surface properties. Here, we demonstrate a novel method for assembling responsive and functional microstructures from diverse particles modified with DNA strands. The DNA strands are designed to form hairpins at room temperature and denature when heated...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28827785/a-highly-sensitive-plasma-based-amyloid-%C3%AE-detection-system-through-medium-changing-and-noise-cancellation-system-for-early-diagnosis-of-the-alzheimer-s-disease
#20
Yong Kyoung Yoo, Jinsik Kim, Gangeun Kim, Young Soo Kim, Hye Yun Kim, Sejin Lee, Won Woo Cho, Seongsoo Kim, Sang-Myung Lee, Byung Chul Lee, Jeong Hoon Lee, Kyo Seon Hwang
We developed an interdigitated microelectrode (IME) sensor system for blood-based Alzheimer's disease (AD) diagnosis based on impedimetric detection of amyloid-β (Aβ) protein, which is a representative candidate biomarker for AD. The IME sensing device was fabricated using a surface micromachining process. For highly sensitive detection of several tens to hundreds of picogram/mL of Aβ in blood, medium change from plasma to PBS buffer was utilized with signal cancellation and amplification processing (SCAP) system...
August 21, 2017: Scientific Reports
keyword
keyword
91294
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"