keyword
https://read.qxmd.com/read/36705399/salvianolic-acid-b-as-a-potent-nano-agent-for-enhanced-ala-pdt-of-oral-cancer-and-leukoplakia-cells
#21
JOURNAL ARTICLE
Ying Zhang, Sai Ye, Yongmei Zhou, Zengtong Zhou, Yilin Yao, Wei Liu, Lan Wu
BACKGROUND: Photodynamic therapy (PDT) relies on the light activation of a photosensitizers to generate reactive oxygen species such as singlet oxygen, but its effect on cancer therapy is limited dramatically by hypoxia in the tumor microenvironment. OBJECTIVES: To determine the potential of a nano-photosensitizer loaded salvianolic acid B (SalB) and 5-aminolevulinic acid (ALA) for enhanced the efficacy of PDT in oral squamous cell carcinoma Cal27 cells and leukoplakia Leuk1 cells...
January 27, 2023: Oral Diseases
https://read.qxmd.com/read/36526028/smjaz4-interacts-with-smmyb111-or-smmyc2-to-inhibit-the-synthesis-of-phenolic-acids-in-salvia-miltiorrhiza
#22
JOURNAL ARTICLE
Rao Yang, Shasha Li, Shuai Dong, Long Wang, Huiting Qin, Hongbin Zhan, Donghao Wang, Xiaoyan Cao, Hongxing Xu
Jasmonic acid (JA), as an important plant hormone, can induce the synthesis of phenolic acids in Salvia miltiorrhiza Bunge, a model medicinal plant, but the specific mechanism remains to be further elucidated. JA-responsive SmMYB111 positively regulates the biosynthesis of salvianolic acid B (SalB), but the molecular mechanism is unclear. Here, we found that SmMYB111 directly binds to the promoters of SmTAT1 and SmCYP98A14 and activates their transcription. Yeast two hybrid and bimolecular fluorescent complementation assay indicated that SmMYB111 interacts with SmJAZ4...
December 13, 2022: Plant Science: An International Journal of Experimental Plant Biology
https://read.qxmd.com/read/36500603/salvianolic-acid-b-strikes-back-new-evidence-in-the-modulation-of-expression-and-activity-of-matrix-metalloproteinase-9-in-mda-mb-231-human-breast-cancer-cells
#23
JOURNAL ARTICLE
Andrea Ianni, Pierdomenico Ruggeri, Pierangelo Bellio, Francesco Martino, Giuseppe Celenza, Giuseppe Martino, Nicola Franceschini
Salvianolic acid B (SalB) is a bioactive compound from Salviae miltiorrhizae , one of the most important traditional herbal medicines widely used in several countries for the treatment of cardiovascular diseases. The aim of this study was to evaluate the in vitro effect of SalB on the expression and the activity of matrix metalloproteinase 9 (MMP-9), a zinc-dependent proteolytic enzyme, in human MDA-MB-231 breast cancer cells. This cellular model is characterized by a marked invasive phenotype, supported by a high constitutive expression of MMPs, especially gelatinases...
December 3, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36362335/transcription-factor-sm-spl2-inhibits-the-accumulation-of-salvianolic-acid-b-and-influences-root-architecture
#24
JOURNAL ARTICLE
Xiangzeng Wang, Yao Cao, Jiaxin Yang, Tong Zhang, Qianqian Yang, Yanhua Zhang, Donghao Wang, Xiaoyan Cao
The SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE (SPL) transcription factor play vital roles in plant growth and development. Although 15 SPL family genes have been recognized in the model medical plant Salvia miltiorrhiza Bunge, most of them have not been functionally characterized to date. Here, we performed a careful characterization of SmSPL2 , which was expressed in almost all tissues of S. miltiorrhiza and had the highest transcriptional level in the calyx. Meanwhile, Sm SPL2 has strong transcriptional activation activity and resides in the nucleus...
November 4, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36277894/to-analyze-the-mechanism-of-salb-regulating-sirt1-to-inhibit-nlrp3-and-its-ameliorative-effect-on-tubulogastric-junction-tumor-lesions-complicated-with-myocardial-injury
#25
JOURNAL ARTICLE
Guo-Ping Wang, Zheng Guo
The objective of this research is to investigate the mediating impact of salvianolic acid B (SalB) on SIRT1 signaling pathway and the mechanism by which it inhibits Nod-like receptor protein 3 (NLRP3), as well as to examine how SalB affects myocardial injury brought on by tumor lesions at the junction of the tube and the stomach. Through the establishment of the integration of a stomach tube tumor lesion rats combined with the experimental rat model, this study establishes the normal group, model group, and different SalB dose groups...
2022: BioMed Research International
https://read.qxmd.com/read/36240743/presumed-tetanus-in-a-temminck-s-pangolin-smutsia-temminckii
#26
JOURNAL ARTICLE
Charlotte E Bentley, Victoria Curr-Smith, Laston Chimaliro, Amanda Lee Salb
An adult female Temminck's pangolin (Smutsia temminckii) confiscated from the illegal wildlife trade presented with an ulcerated lesion of the right forelimb. Neurologic signs and tonic spasms characteristic of tetanus developed after 5 d. Despite supportive treatment, the pangolin died. Tetanus has not previously been reported in any pangolin species.
October 14, 2022: Journal of Wildlife Diseases
https://read.qxmd.com/read/36237221/salvianolic-acid-b-combined-with-bone-marrow-mesenchymal-stem-cells-piggybacked-on-hama-hydrogel-re-transplantation-improves-intervertebral-disc-degeneration
#27
JOURNAL ARTICLE
Jie Hu, Cai Li, Shichang Jin, Yuchen Ye, Yuekun Fang, Panpan Xu, Changchun Zhang
Cell-based tissue engineering approaches have emerged as a realistic alternative for regenerative disc tissue repair. The multidirectional differentiation potential of bone marrow mesenchymal stem cells (BMSCs) to treat disc degeneration intervertebral disc degeneration has also become a viable option. We used 1% HAMA hydrogel as a carrier and co-encapsulated BMSCs and Salvianolic acid B (SalB) into the hydrogel to reduce the apoptosis of the transplanted cells. The protective effect of SalB on BMSCs was first verified in vitro using the CCK8 method, flow cytometry, and Western-Blotting, and the physical properties and biocompatibility of HAMA hydrogels were verified in vitro ...
2022: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/35968584/salvianolic-acid-b-inhibits-myocardial-i-r-induced-ros-generation-and-cell-apoptosis-by-regulating-the-trim8-gpx1-pathway
#28
JOURNAL ARTICLE
Bo Lu, Jianhua Li, MingTai Gui, Lei Yao, Mingsong Fan, Xunjie Zhou, Deyu Fu
CONTEXT: Salvianolic acid B (SalB) can attenuate myocardial ischemia/reperfusion (I/R) injury, but the mechanisms are not entirely known. OBJECTIVE: Our study investigates if SalB protects cardiomyocytes against I/R injury by regulating Tripartite motif (TRIM) protein. MATERIALS AND METHODS: AC16 cardiomyocytes were treated with I/R, and then with SalB (10, 25 and 50 μM) for 24 h, while control cells were cultured under normal conditions...
December 2022: Pharmaceutical Biology
https://read.qxmd.com/read/35932615/salvianolic-acid-b-ameliorates-non-alcoholic-fatty-liver-disease-by-inhibiting-hepatic-lipid-accumulation-and-nlrp3-inflammasome-in-ob-ob-mice
#29
JOURNAL ARTICLE
Ling-Cui Meng, Jia-Yi Zheng, Yu-Hui Qiu, Li Zheng, Jue-Yan Zheng, Yu-Qing Liu, Xiao-Lu Miao, Xin-Yi Lu
Non-alcoholic fatty liver disease (NAFLD) has high occurrence in the global world, which poses serious threats to human health. Salvianolic acid B (SalB), an extract of the root of Salvia miltiorrhiza, has the protective effect on metabolic homeostasis. However, the mechanism is still unknown. In this study, we used ob/ob mice, a model of NAFLD, to explore the hepatoprotective effects of SalB. The results showed that SalB significantly reduced the body weights and liver weights, and ameliorated plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), hepatic free fatty acid (FFA), total cholesterol (TC) levels, and hepatic TG and TC levels in ob/ob mice...
October 2022: International Immunopharmacology
https://read.qxmd.com/read/35911499/association-between-serum-albumin-level-and-microvascular-complications-of-type-2-diabetes-mellitus
#30
JOURNAL ARTICLE
Jie Zhang, Yuanyuan Deng, Yang Wan, Shasha He, Wei Cai, Jixiong Xu
Objective: To analyze the associations between serum albumin (sALB) level and diabetic microvascular complications, including diabetic retinopathy (DR) and diabetic kidney disease (DKD), in patients with type 2 diabetes mellitus (T2DM). Methods: This retrospective study included 951 hospitalized patients with T2DM who had completed screening for DR and DKD during hospitalization. Patients were divided into three groups according to sALB tertiles. Multivariate logistic regression analysis was used to assess the association of sALB with microvascular complications...
2022: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/35879423/cholesterol-affects-the-relationship-between-albumin-and-major-adverse-cardiac-events-in-patients-with-coronary-artery-disease-a-secondary-analysis
#31
JOURNAL ARTICLE
Yu-Feng Yao, Zhen-Yu Chen, Tian-Yi Luo, Xiao-Yan Dou, Hai-Bo Chen
We aimed to examine whether the efficacy of the risk of poor prognosis in patients with coronary artery disease is jointly affected by total cholesterol and baseline serum albumin in a secondary analysis of previous study. We analyzed the data of 204 patients from October 2014 to October 2017 for newly diagnosed stable CAD. The outcome was major adverse cardiac events (MACE; defined as all cause mortality, non fatal myocardial infarction, and non fatal stroke). The median duration of follow-up was 783 days...
July 25, 2022: Scientific Reports
https://read.qxmd.com/read/35842368/the-impact-of-burr-hole-device-and-lead-design-on-deep-brain-stimulation-lead-stability-in-benchtop-and-ovine-models
#32
JOURNAL ARTICLE
Walt Baxter, Kelly Salb, Michelle Case, Tina Billstrom
BACKGROUND AND OBJECTIVES: A market-released deep brain stimulation (DBS) lead and burr hole device (BHD) have been used for more than ten years to provide stable DBS therapy using leads with four equally distributed cylindrical electrodes along the distal lead length. Newer directional leads cluster segmented electrodes at the center of the electrode array. This work tests the hypothesis that improved chronic translational and rotational stability through enhanced BHD design may ensure that these newer directional electrodes remain in a stable orientation near the stimulation target to maintain therapy and maximize opportunities to adjust therapy, if needed...
July 14, 2022: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/35809215/salvianolic-acid-b-alleviates-myocardial-ischemia-injury-by-suppressing-nlrp3-inflammasome-activation-via-sirt1-ampk-pgc-1%C3%AE-signaling-pathway
#33
JOURNAL ARTICLE
Qingju Li, Zhi Zuo, Yunzheng Pan, Qi Zhang, Li Xu, Baoping Jiang
Salvianolic acid B (SalB) has been extensively investigated in our laboratory for myocardial ischemia (MI) disease. This study mainly aimed to illustrate the relationship between SIRT1 and the therapeutic effect of SalB on MI in rats and hypoxia damage in H9c2 cells. Furthermore, whether the antagonism of NLRP3 by SalB in the injuries mentioned above is related to SIRT1-AMPK-PGC-1α pathway-mediated mitochondrial biogenesis was further investigated. In vivo, 24 h after MI surgery, we found that SalB effectively reduced ST-segment elevation, myocardial infarct size enlargement, cardiac injury markers, myocardial structural abnormalities, and myocardial apoptotic cells in MI injury rats...
September 2022: Cardiovascular Toxicology
https://read.qxmd.com/read/35795853/inhalation-of-salvianolic-acid-b-prevents-fine-particulate-matter-induced-acute-airway-inflammation-and-oxidative-stress-by-downregulating-the-ltr4-myd88-nlrp3-pathway
#34
JOURNAL ARTICLE
Yan Guan, Liucheng Li, Liandi Kan, Qiangmin Xie
Air pollution is a serious threat to human health. Inhaled fine particulate matter (PM2.5) can cause inflammation and oxidative stress in the airway; however, the mechanisms responsible for this effect have yet to be elucidated and there are no specific drugs that can prevent and treat this condition. In the present study, we investigated the effects and mechanisms underlying the inhalation of salvianolic acid B (SalB) on PM2.5-induced airway inflammation and oxidative stress. We used a PM2.5-induced mouse model of airway inflammation and oxidative stress, along with a human epithelial cell model, to study the action and mechanisms of SalB by histopathology, real-time PCR, enzyme-linked immunosorbent assays, flow cytometry, and western blotting...
2022: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/35779815/pharmacological-manipulation-of-ezh2-with-salvianolic-acid-b-results-in-tumor-vascular-normalization-and-synergizes-with-cisplatin-and-t-cell-mediated-immunotherapy
#35
JOURNAL ARTICLE
Cheng Qian, Chunmei Yang, Yu Tang, Weiwei Zheng, Yueke Zhou, Shan Zhang, Mengyao Song, Peng Cheng, Zhonghong Wei, Chongjin Zhong, Li Wan, Aiyun Wang, Yang Zhao, Yin Lu
Tumor vasculature is characterized by aberrant structure and function, resulting in immune suppressive profiles of tumor microenvironment (TME) through limiting immune cell infiltration into tumors. The defective vascular perfusion in tumors also impairs the delivery and efficacy of chemotherapeutic agents. Targeting abnormal tumor blood vessels has emerged as an effective therapeutic strategy to improve the outcome of chemotherapy and immunotherapy. In this study, we demonstrated that Salvianolic acid B (SalB), one of the major ingredients of Salvia miltiorriza elicited vascular normalization in the mouse models of breast cancer, contributing to improved delivery and response of chemotherapeutic agent cisplatin as well as attenuated metastasis...
June 29, 2022: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/35723058/salvianolic-acid-b-attenuates-membranous-nephropathy-by-activating-renal-autophagy-via-microrna-145-5p-phosphatidylinositol-3-kinase-akt-pathway
#36
JOURNAL ARTICLE
Junqi Chen, Qinghong Hu, Yini Luo, Lina Luo, Hua Lin, Dandan Chen, Yuan Xu, Bihao Liu, Yu He, Chunling Liang, Yaoyu Liu, Jiuyao Zhou, Junbiao Wu
The abnormal proliferation and inflammatory response of the mesangial cells play a crucial role in the progression of membranous nephropathy (MN). Herein, this study aimed to investigate the therapeutic effect of Salvianolic acid B (SalB) on MN-induced mesangial abnormalities and its underlying mechanisms. MN models were established in cationic bovine serum albumin-induced Sprague-Dawley rats and lipopolysaccharide-induced human mesangial cells (HMCs). Following SalB and microRNA-145-5p antagomir treatment, kidney function was investigated by 24-hours urine protein, serum creatinine, and blood urea nitrogen...
May 2022: Bioengineered
https://read.qxmd.com/read/35652052/agonist-promoted-phosphorylation-and-internalization-of-the-kappa-opioid-receptor-in-mouse-brains-lack-of-connection-with-conditioned-place-aversion
#37
JOURNAL ARTICLE
Chongguang Chen, Peng Huang, Kathryn Bland, Mengchu Li, Yan Zhang, Lee-Yuan Liu-Chen
Selective kappa opioid receptor (KOR) agonists are promising antipruritic agents and analgesics. However, clinical development of KOR agonists has been limited by side effects, including psychotomimetic effects, dysphoria, and sedation, except for nalfurafine, and recently. CR845 (difelikefalin). Activation of KOR elicits G protein- and β-arrestin-mediated signaling. KOR-induced analgesic and antipruritic effects are mediated by G protein signaling. However, different results have been reported as to whether conditioned place aversion (CPA) induced by KOR agonists is mediated by β-arrestin signaling...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/35500448/salvianolic-acid-b-alleviates-comorbid-pain-in-depression-induced-by-chronic-restraint-stress-through-inhibiting-gabaergic-neuron-excitation-via-an-erk-creb-bdnf-axis-dependent-mechanism
#38
JOURNAL ARTICLE
Xinxin Liu, Zixin Hou, Mingming Han, Kemin Chen, Yuxia Wang, Jie Qing, Fengrui Yang
Pain comorbid with depression occurred frequently in clinical settings. This study aims to explore the molecular mechanism underlying antidepressant and analgetic effect of salvianolic acid B (SalB) in comorbid pain in depression induced by chronic restraint stress (CRS), which associates with GABAergic neuron activation in the amygdala and the ERK-CREB-BDNF signaling pathway. The differentially expressed genes related to comorbid pain in CRS-induced depression were screened through bioinformatics analysis...
July 2022: Journal of Psychiatric Research
https://read.qxmd.com/read/35386617/salvianolic-acid-b-improves-the-survival-rate-acute-kidney-dysfunction-inflammation-and-netosis-mediated-antibacterial-action-in-a-crush-syndrome-rat-model
#39
JOURNAL ARTICLE
Isamu Murata, Tsugumi Sugai, Yumiko Murakawa, Yoshiaki Miyamoto, Jun Kobayashi, Yutaka Inoue, Ikuo Kanamoto
Crush syndrome (CS) is a potentially lethal condition characterized by muscle cell damage resulting from decompression following compression. Patients with CS can develop cardiac failure, kidney dysfunction, shock, systemic inflammation and sepsis. Salvianolic acid B (SalB) has cardiac and kidney protective effects and anti-oxidative, anti-inflammatory, anti-apoptotic and anti-bacterial properties. The present study aimed to demonstrate the survival benefit of SalB in the CS rat model, which comprised anesthetized rats with bilateral hindlimb compression by a rubber tourniquet for 5 h...
May 2022: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/35373711/development-and-internal-validation-of-machine-learning-algorithms-for-end-stage-renal-disease-risk-prediction-model-of-people-with-type-2-diabetes-mellitus-and-diabetic-kidney-disease
#40
JOURNAL ARTICLE
Yutong Zou, Lijun Zhao, Junlin Zhang, Yiting Wang, Yucheng Wu, Honghong Ren, Tingli Wang, Rui Zhang, Jiali Wang, Yuancheng Zhao, Chunmei Qin, Huan Xu, Lin Li, Zhonglin Chai, Mark E Cooper, Nanwei Tong, Fang Liu
AIMS: Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease (ESRD) and is associated with increased morbidity and mortality in patients with diabetes. Identification of risk factors involved in the progression of DKD to ESRD is expected to result in early detection and appropriate intervention and improve prognosis. Therefore, this study aimed to establish a risk prediction model for ESRD resulting from DKD in patients with type 2 diabetes mellitus (T2DM). METHODS: Between January 2008 and July 2019, a total of 390 Chinese patients with T2DM and DKD confirmed by percutaneous renal biopsy were enrolled and followed up for at least 1 year...
December 2022: Renal Failure
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