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JOURNAL ARTICLE
Guo-Qiang Zeng, Yu-Feng Yao, Jian-Bo Zhong, Yi Zhang, Bai-Kang Ye, Xiao-Yan Dou, Li Cai
BACKGROUND: Most studies had shown a linear relationship between serum albumin (sALB) and the prevalence of diabetic retinopathy (DR). Thus, the purpose of this study is to investigate whether their relationship is non-linear. METHODS: We included 426 patients with type 2 diabetes who were hospitalized in Guangdong Provincial People's Hospital from December 2017 to November 2018. The outcome was the prevalence of DR. A two-piecewise logistics regression model was performed to identify the non-linear relationship between sALB and the prevalence of DR...
March 1, 2024: BMC Ophthalmology
#2
JOURNAL ARTICLE
Jiale Ou, Hui Tao, Quan Bao, Yuejia Dai, Qi Wang, Qi Chen, Yan Feng, Xiangming Meng
Myocardial fibrosis is frequently accompanied by elevated levels of oxidative stress. Mitochondrial glutathione (mGSH), an essential biomolecule for maintaining redox homeostasis in mitochondria, could serve as an effective indicator for investigating the oxidative stress associated with myocardial fibrosis. In this study, a ratiometric fluorescent probe named Mito-NS6 , capable of being anchored in mitochondria and reversibly responding to GSH with an appropriate dissociation equilibrium constant, was rationally designed and utilized to visualize and evaluate the changes of mGSH levels caused by oxidative stress in myocardial fibrosis...
February 29, 2024: Analytical Chemistry
#3
JOURNAL ARTICLE
Yaping Wu, Zhenjian Lin, Yuyan Bao, Yuebo Liu, Xiaomin Zhang
BACKGROUND: Cardiotoxicity has been corroborated to be the toxic influence of cisplatin (CDDP). Oxidative stress and cardiomyocyte apoptosis play a vital part in cardiotoxicity induced by CDDP. Salvianolic acid Salvianolic acid B (SalB) is a monomeric component of Salvia miltiorrhiza, which has antioxidant and anti-inflammatory influences. In this research, we explored the mechanism of SalB in cardiotoxicity induced by CDDP. METHOD: 36 Wistar rats were separated into sham subgroup, CDDP (10 mg/kg) subgroup, CDDP (10 mg/kg) + SalB (1 μM) subgroup at random, CDDP (10 mg/kg) + SalB (5 μM) subgroup and CDDP (10 mg/kg) + SalB (10 μM) subgroup, Nicotinic Acid Riboside (NAR, 5 μM), with 6 rats in each subgroup...
February 2024: Discovery Medicine
#4
JOURNAL ARTICLE
Siwei Zhang, Xinlan Qi, Ruiyan Zhu, Dongdong Ye, Minyu Shou, Lulu Peng, Minghua Qiu, Min Shi, Guoyin Kai
Phenolic acids are one of the major secondary metabolites accumulated in Salvia miltiorrhiza with various pharmacological activities. Moderate drought stress can promote the accumulation of phenolic acids in S. miltiorrhiza , while the mechanism remains unclear. Therefore, we performed transcriptome sequencing of S. miltiorrhiza under drought treatment. A total of 47,169 unigenes were successfully annotated in at least one of the six major databases. Key enzyme genes involved in the phenolic acid biosynthetic pathway, including SmPAL , SmC4H , Sm4CL , SmTAT , SmHPPR , SmRAS and SmCYP98A14 , were induced...
January 6, 2024: Plants (Basel, Switzerland)
#5
BioMed Research International
[This retracts the article DOI: 10.1155/2022/6560693.].
2024: BioMed Research International
#6
JOURNAL ARTICLE
Meng-Chao Liu, Wen-Quan Niu, Yue-Fen Wang, Yuan Meng, Gui-Min Zheng, Zhen Cai, Cun Shen, Xiang-Gang Zhu, Meng-di Wang, Jia-Lin Li, Wen-Jing Zhao, Yao-Xian Wang
OBJECTIVES: Type 2 diabetic kidney disease (DKD), a chronic microvascular complication of diabetes, may exhibit a complex interrelation with coagulation function. This study is aimed at elucidating the association between coagulation function and DKD. METHODS: This was a real-world observational study conducted in Beijing, involving 2,703 participants. All patients with diabetes were classified into two groups, viz., DKD and non-DKD groups. Effect magnitudes are denoted as odds ratios (OR) with a 95% confidence interval (CI)...
2023: Journal of Diabetes Research
#7
JOURNAL ARTICLE
Mingming Xu, Hang Zhou, Yang Pan, Zhunan Xu, Xiaoqiang Liu
BACKGROUND: Serum albumin (sAlb) is an essential indicator of human physiological function. However, the correlation between the concentration of sAlb and stress urinary incontinence (SUI) remains poorly understood. METHODS: The sAlb was measured using the bichromatic digital endpoint method. The SUI was assessed according to information from the National Health and Nutrition Examination Survey (NHANES) questionnaire. Univariate and multivariate logistic regression analyses of the potential correlation between sAlb and stress incontinence were performed...
November 2023: Heliyon
#8
JOURNAL ARTICLE
Shijun Bi, Hao Lin, Kunyuan Zhu, Zechao Zhu, Wenxu Zhang, Xinyu Yang, Shanshan Chen, Jing Zhao, Meixia Liu, Pengyu Pan, Guobiao Liang
Introduction: Intracranial stents are of paramount importance in managing cerebrovascular disorders. Nevertheless, the currently employed drug-eluting stents, although effective in decreasing in-stent restenosis, might impede the re-endothelialization process within blood vessels, potentially leading to prolonged thrombosis development and restenosis over time. Methods: This study aims to construct a multifunctional bioactive coating to enhance the biocompatibility of the stents. Salvianolic acid B (SALB), a bioactive compound extracted from Salvia miltiorrhiza, exhibits potential for improving cardiovascular health...
2023: Frontiers in Bioengineering and Biotechnology
#9
JOURNAL ARTICLE
Farid Mostafaei, Salar Hemmati, Hadi Valizadeh, Mohammad Mahmoudian, Muhammad Sarfraz, Mahdieh Abdi, Shukoofeh Torabi, Behzad Baradaran, Massoud Vosough, Parvin Zakeri-Milani
Asialoglycoprotein receptors (ASGPRs) are highly expressed on hepatocytes and have been used for liver-targeted delivery and hepatocellular carcinoma (HCC) therapy. However, targeted delivery of bortezomib (BTZ) to HCC has not been reported. In this study, N-stearyl lactobionamide (N-SALB) with galactose (Gal) moiety was synthesized as a targeting agent and its structure was confirmed by FT-IR and NMR analyses. N-SALB surface-modified solid lipid nanoparticles (SLNs) loaded with BTZ (Gal-SLNs/BTZ) were developed to target BTZ delivery into HCC cancer cells...
November 22, 2023: International Journal of Pharmaceutics
#10
JOURNAL ARTICLE
Qian Zhang, Ying Li, Shuai Wang, Donghao Gu, Cuihua Zhang, Shihao Xu, Xiaoli Fang, Chenyang Li, Haiqiang Wu, Wei Xiong
There is increasingly keen interest in developing orally delivered targeted drugs, especially for diseases that require long-term medication. Hence, we manufactured nanoparticles derived from methoxypolyethylene glycol-chitosan (PCS) to enhance the oral delivery and kidney-targeted distribution of salvianolic acid B (SalB), a naturally occurring renoprotective and anti-fibrotic compound, as a model drug for the treatment of renal fibrosis. Orally administered SalB-loaded PCS nanoparticles (SalB-PCS-NPs) maintained good stability in the gastrointestinal environment, improved mucus-penetrating capacity, and enhanced transmembrane transport through a Caco-2 cell monolayer...
November 22, 2023: International Journal of Biological Macromolecules
#11
JOURNAL ARTICLE
Yuan Zhao, Xin Liu, Xiang Liu, Jian Zhang, Yidan Zhang, Ya Wen, Guofeng Yang
BACKGROUND: Salvianolic acid B (SalB) is a bioactive extract of Salvia miltiorrhiza with the ability to ameliorate amyloid beta (Aβ)-induced neuronal degeneration and neuroinflammation in Alzheimer's disease (AD). However, the underlying mechanisms of this action have not been elucidated. Herein, we aimed to investigate whether the neuroprotective effect of SalB is attributable to the modulation of microglial polarization and NLRP3 inflammasome-mediated neuroinflammation. METHODS: Based on the TMT-labeled proteomics analysis, immunofluorescence, western blot and quantitative reverse transcription polymerase chain reaction (qRT-PCR) were employed to investigate the effects of SalB on neuroinflammation in Aβ1-42-stimulated BV2 microglia cells...
October 26, 2023: Tissue & Cell
#12
JOURNAL ARTICLE
Lyda Constanza Galindo-Rodríguez, Armando Sterling, Herminton Muñoz-Ramirez, Jesica Andrea Fonseca-Restrepo
The cultivation of Hevea brasiliensis , the primary commercial source of natural rubber, is strongly impacted by South American leaf blight (SALB) disease, caused by the fungus Pseudocercospora ulei . Various management strategies have been implemented, including the selection of resistant genotypes and the identification of escape zones. This study evaluated the growth, early yield, and resistance to SALB of nine Colombian elite genotypes from the ECC-100 series and IAN 873 clone (control) in a large-scale clone trial in an area with low SALB pressure in the Colombian Amazon during 2017-2020...
October 20, 2023: Plants (Basel, Switzerland)
#13
JOURNAL ARTICLE
Sigal Klainbart, Efrat Kelmer, Iris Beeri-Cohen, Yael Keinan, Gilad Segev, Itamar Aroch
Daboia ( Vipera ) palaestinae ( Dp ), accounts for most envenomations in humans and dogs in Israel. In humans envenomed by Dp , serum cholesterol concentration (sChol) is inversely correlated with envenomation severity. This study examined the utility of sChol upon admission in dogs envenomed by Dp as an envenomation severity and outcome marker. Data upon admission, including sChol, were retrospectively collected from the medical records of dogs with proven Dp envenomation. The study included 415 dogs. The mortality rate was 11%...
October 12, 2023: Toxins
#14
JOURNAL ARTICLE
Jacob K Al-Husseini, Ethan M Fong, Chris Wang, Joseph H Ha, Meenakshi Upreti, Peter A Chiarelli, Malkiat S Johal
Despite advancements in contemporary therapies, cardiovascular disease from atherosclerosis remains a leading cause of mortality worldwide. Supported lipid bilayers (SLBs) are membrane interfaces that can be constructed with varying lipid compositions. Herein, we use a solvent-assisted lipid bilayer (SALB) construction method to build SLB membranes with varying cholesterol compositions to create a lipid-sterol interface atop a piezoelectric sensor. These cholesterol-laden SLBs were utilized to investigate the mechanisms of various cholesterol-lowering drug molecules...
September 12, 2023: Langmuir: the ACS Journal of Surfaces and Colloids
#15
JOURNAL ARTICLE
X Zhuang, Y Y Chen, C Wang, N Zhang, Y Zhang, J H Lin
Objective: To investigate the difference of urinary protein components in pregnant women with pre-eclampsia (PE) with different degrees of proteinuria and the correlation between 24-hour urinary protein quantification and estimated glomerular filtration rate (eGFR). Methods: Clinical data of 101 PE pregnant women who were delivered in Renji Hospital, Shanghai Jiao Tong University School of Medicine from July 2018 to June 2022 were retrospectively analyzed. According to 24-hour urinary protein quantification, they were divided into 3 groups, including 40 cases of mild proteinuria group (24-hour urinary protein quantification ≤2...
August 25, 2023: Zhonghua Fu Chan Ke za Zhi
#16
JOURNAL ARTICLE
Dayong Xia, Jinlong Yuan, Degang Wu, Haibin Dai, Zong Zhuang
The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated immuno-inflammatory response plays a critical role in exacerbating early brain injury (EBI) after subarachnoid hemorrhage (SAH). Salvianolic acid B (SalB) has previously been shown to suppress neuroinflammatory responses in many disorders. Meanwhile, a previous study has demonstrated that SalB mitigated oxidative damage and neuronal degeneration in a prechiasmatic injection model of SAH...
2023: Frontiers in Immunology
#17
JOURNAL ARTICLE
Junyeon Won, Kristy A Nielson, J Carson Smith
BACKGROUND: Despite growing evidence regarding the association between exercise training (ET) and functional brain network connectivity, little is known about the effects of ET on large-scale within- and between-network functional connectivity (FC) of core brain networks. OBJECTIVE: We investigated the effects of ET on within- and between-network functional connectivity of the default mode network (DMN), frontoparietal network (FPN), and salience network (SAL) in older adults with intact cognition (CN) and older adults diagnosed with mild cognitive impairment (MCI)...
2023: JAD Reports
#18
JOURNAL ARTICLE
Zhao Zhiqiang, Zhang Chong, Zhu Yunxia
OBJECTIVE: To elucidate the regulatory effects of salvianolic acid B (SalB) on trophoblast cells in preeclampsia (PE). METHODS: 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenylte-trazolium bromide (MTT) assays were used to detect the viability of human extravillous trophoblast HTR-8/Svneo cells induced by HO following treatment with different concentrations of SalB. The levels of oxidative stress-related molecules, including superoxide dismutase, glutathione-Px and malondialdehyde were detected using corresponding kits...
June 2023: Journal of Traditional Chinese Medicine
#19
JOURNAL ARTICLE
Ana Lucia Monteiro Wanzeller, Fabio Silva da Silva, Leonardo Henrique Almeida Hernández, Landerson Junior Leopoldino Barros, Maria Nazaré Oliveira Freitas, Maissa Maia Santos, Ercília de Jesus Gonçalves, Jamilla Augusta Sousa Pantoja, Creuza de Sousa Lima, Maxwell Furtado Lima, Luiz Roberto Oliveira Costa, Liliane Leal das Chagas, Iveraldo Ferreira Silva, Tania Cristina Alves da Silveira da Cunha, Bruna Lais Sena do Nascimento, Helena Baldez Vasconcelos, Elizabeth Salbe Travassos da Rosa, Sueli Guerreiro Rodrigues, Raimunda do Socorro da Silva Azevedo, Lívia Carício Martins, Lívia Medeiros Neves Casseb, Jannifer Oliveira Chiang, Joaquim Pinto Nunes Neto, Ana Cecília Ribeiro Cruz, Valéria Lima Carvalho, Pedro Fernando da Costa Vasconcelos, Eliana Vieira Pinto da Silva
Viruses with encephalitogenic potential can cause neurological conditions of clinical and epidemiological importance, such as Saint Louis encephalitis virus , Venezuelan equine encephalitis virus , Eastern equine encephalitis virus , Western equine encephalitis virus , Dengue virus , Zika virus , Chikungunya virus , Mayaro virus and West Nile virus . The objective of the present study was to determine the number of arboviruses with neuroinvasive potential isolated in Brazil that corresponds to the collection of viral samples belonging to the Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute (SAARB/IEC) of the Laboratory Network of National Reference for Arbovirus Diagnosis from 1954 to 2022...
April 10, 2023: Viruses
#20
JOURNAL ARTICLE
Ester Sevillano, Nuria Peña, Irene Lafuente, Luis M Cintas, Estefanía Muñoz-Atienza, Pablo E Hernández, Juan Borrero
Recently, the food industry and the animal farming field have been working on different strategies to reduce the use of antibiotics in animal production. The use of probiotic producers of antimicrobial peptides (bacteriocins) is considered to be a potential solution to control bacterial infections and to reduce the use of antibiotics in animal production. In this study, Ligilactobacillus salivarius P1CEA3, isolated from the gastrointestinal tract (GIT) of pigs, was selected for its antagonistic activity against Gram-positive pathogens of relevance in swine production...
April 6, 2023: International Journal of Molecular Sciences
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