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Salvianolic acid B

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https://www.readbyqxmd.com/read/29655516/plga-%C3%AE-tcp-composite-scaffold-incorporating-salvianolic-acid-b-promotes-bone-fusion-by-angiogenesis-and-osteogenesis-in-a-rat-spinal-fusion-model
#1
Sien Lin, Liao Cui, Guanghua Chen, Jianping Huang, Yanhua Yang, Kaijie Zou, Yuxiao Lai, Xinluan Wang, Liyi Zou, Tie Wu, Jack Chun Yiu Cheng, Gang Li, Bo Wei, Wayne Yuk Wai Lee
Spinal disorders often require surgical treatment called spinal fusion to restore a stabilized spine where bone grafts are implanted for the fusion of adjacent vertebras. In this study, we developed a bioactive composite scaffold incorporated with salvianolic acid B (SB), an active component extracted from Danshen. This study aimed to evaluate the effects of SB-incorporated porous scaffold on spinal fusion models. The composite scaffolds composed of poly (lactic-co-glycolic acid) and tricalcium phosphate (PLGA/β-TCP) were fabricated with low-temperature rapid prototyping technique, which incorporated SB at low (SB-L), middle (SB-M), high (SB-H) doses, and pure PLGA/β-TCP as blank control (Con)...
April 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29619899/salvia-przewalskii-extract-of-total-phenolic-acids-inhibit-tlr4-signaling-activation-in-podocyte-injury-induced-by-puromycin-aminonucleoside-in-vitro
#2
Hongqi Ren, Xueqing Hu, Yun Liu, Deshu Dai, Xiang Liu, Zenghui Wang, Yang Yang, Xiangyang Li, Ying Liu, Renxian Tang
BACKGROUND: TLR4 signaling is known to be involved in podocyte injury. We have previously shown that Salvia przewalskii extract of total phenolic acids (SPE) and its active monomer salvianolic acid B (SalB) and rosmarinic acid (RA) protect podocytes from injury induced by PAN. In the present study, we test whether SPE inhibits TLR4 signaling. METHODS: The conditionally immortalized mouse podocytes were treated with SPE, SalB, RA, SalB + RA or tacrolimus for 30 min, followed by PAN (100 μg/mL) for 24 h...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29587860/roles-of-astrocytic-connexin-43-hemichannels-and-gap-junctions-in-oxygen-glucose-deprivation-reperfusion-injury-induced-neuroinflammation-and-the-possible-regulatory-mechanisms-of-salvianolic-acid-b-and-carbenoxolone
#3
Xiang Yin, Liangshu Feng, Di Ma, Ping Yin, Xinyu Wang, Shuai Hou, Yulei Hao, Jingdian Zhang, Meiying Xin, Jiachun Feng
BACKGROUND: Glia-mediated neuroinflammation is related to brain injury exacerbation after cerebral ischemia/reperfusion (I/R) injury. Astrocytic hemichannels or gap junctions, which were mainly formed by connexin-43, have been implicated in I/R damage. However, the exact roles of astrocytic hemichannels and gap junction in neuroinflammatory responses induced by I/R injury remain unknown. METHODS: Primary cultured astrocytes were subjected to OGD/R injury, an in vitro model of I/R injury...
March 27, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29578591/inhibitory-effects-of-danhong-injection-and-its-major-constituents-on-human-cytochrome-p450-enzymes-in-vitro
#4
Lin-Hu Ye, Xin-Qian Zhao, Ling-Ti Kong, Li-Sha Wang, Xue Tao, Hui Wu, Mei He, Qi Chang
Danhong Injection (DHI),as a Chinese patent medicine, which is mainly used to treat ischemic encephalopathy and coronary heart disease in combination with other chemotherapy. However, the information on DHI that cause potential drug interaction is limited. The goal of this work was to examine the potential P450-mediated metabolism drug interaction arising by the DHI and its active components. The results showed that DHI inhibited CYP2C19, CYP2D6, CYP3A4, CYP2E1 and CYP2C9 with the IC50 values of 1.26%, 1.42%, 1...
March 26, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29573136/adsorbed-hollow-fiber-based-biological-fingerprinting-for-the-discovery-of-platelet-aggregation-inhibitors-from-danshen-honghua-decoction
#5
Qian Zhang, Cheng-Ning Tan, Ya-Li Wang, Wen-Jing Liu, Feng-Qing Yang, Hua Chen, Zhi-Ning Xia
For lead compound discovery from natural products, hollow fiber cell fishing with chromatographic analysis was a newly developed method. In this study, an adsorbed hollow fiber based biological fingerprinting method was firstly developed to discover potential platelet aggregation inhibitors from Danshen-Honghua decoction. Platelets were seeded on the fiber and their survival rate was tested. Results indicated that more than 92% platelets survived during the whole operation process. Ranitidine and tirofiban were used as positive and negative control respectively to verify the reliability of the presented approach...
March 23, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29551684/salvianolic-acid-b-attenuates-mitochondrial-stress-against-a%C3%AE-toxicity-in-primary-cultured-mouse-neurons
#6
Yan He, Kun Jia, Lei Li, Qi Wang, Shuhui Zhang, Jiaming Du, Heng Du
Mitochondrial dysfunction is a featured pathology underlying synaptic injury and neuronal stress in Alzheimer's disease (AD). In recent years, the vicious cycle between mitochondrial deficits and intra-neuronal Redox state imbalance has received considerable attention. In this regard, it is of great interest to determine whether antioxidants could alleviate mitochondrial dysfunction in AD-related conditions. Salvianolic acid B (SalB), a bioactive component of alvia miltiorrhiza Bge, is a potent antioxidant...
March 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29544864/a-quality-marker-study-on-salvianolic-acids-for-injection
#7
Wei Li, Navaneethakrishnan Polachi, Xiangyang Wang, Yang Chu, Yuan Wang, Meng Tian, Dekun Li, Dazheng Zhou, Shuiping Zhou, Aichun Ju, Yubo Li, Yanjun Zhang, Min Chen, Luqi Huang, Changxiao Liu
BACKGROUND: The quality of Chinese medicine (CM) has being an active and challenging research area for CM. Prof. Chang-Xiao Liu et al first proposed the concept of quality marker (Q-Marker) for the quality evaluation and control on CM. This article describe the exploratory studies of Q-Marker in salvianolic acids for injection (SAI) based on this new concept. PURPOSE: This study was designed to screen Q-Marker of SAI and establish its quality control method based on the concept of CM Q-Marker...
February 10, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29519686/nuciferine-and-paeoniflorin-can-be-quality-markers-of-tangzhiqing-tablet-a-chinese-traditional-patent-medicine-based-on-the-qualitative-quantitative-and-dose-exposure-response-analysis
#8
Ziqiang Li, Jia Liu, Deqin Zhang, Xi Du, Lifeng Han, Chunxiao Lv, Yanfen Li, Ruihua Wang, Baohe Wang, Yuhong Huang
BACKGROUND: Diabetes is a chronic disease associated with significant morbidity and mortality. Tangzhiqing tablet (TZQ), a Chinese traditional patent medicine, has been in phase 2 clinical trial for the treatment of diabetes mellitus. However, the current quality evaluation of TZQ still remains rather obscure. PURPOSE: The promising quality markers (Q-markers) of TZQ will be sought for its quality assessment and process control based on the qualitative, quantitative and dose-exposure-response analysis...
February 21, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29498696/synergistic-effects-of-salvianolic-acid-b-and-puerarin-on-cerebral-ischemia-reperfusion-injury
#9
Chengli Ling, Jianming Liang, Chun Zhang, Ruixiang Li, Qianqian Mou, Jin Qin, Xiaofang Li, Jianxin Wang
Ischemic stroke (IS) is characterized by the sudden loss of blood circulation to an area of the brain, resulting in a corresponding loss of neurologic function. It has been a worldwide critical disease threatening to the health and life of human beings. Despite significant progresses achieved, effective treatment still remains a formidable challenge due to the complexity of the disease. Salvianolic acid B (Sal-B) and Puerarin (Pue) are two active neuroprotectants isolated from traditional Chinese herbs, Salvia miltiorrhiza and Kudzu root respectively, which have been used for the prevention and treatment of IS for thousands of years in China...
March 2, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29495564/bivariate-correlation-analysis-of-the-chemometric-profiles-of-chinese-wild-salvia-miltiorrhiza-based-on-uplc-qqq-ms-and-antioxidant-activities
#10
Xiaodan Zhang, Yange Yu, Yesheng Cen, Dongfeng Yang, Zhechen Qi, Zhuoni Hou, Shuanglai Han, Zengxuan Cai, Kuancheng Liu
To better understand the mechanisms underlying the pharmacological actions of Salvia miltiorrhiza , correlation between the chemical profiles and in vitro antioxidant activities in 50 batches of wild S. miltiorrhiza samples was analyzed. Our ultra-performance liquid chromatography-tandem mass spectrometry analysis detected twelve phenolic acids and five tanshinones and obtained various chemical profiles from different origins. In a principal component analysis (PCA) and cluster analysis, the tanshinones cryptotanshinone, tanshinone IIA and dihydrotanshinone I exhibited higher weights in PC1, whereas the phenolic acids danshensu, salvianolic acids A and B and lithospermic acid were highly loaded in PC2...
February 28, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29436996/herbal-products-for-common-auto-inflammatory-disorders-novel-approaches
#11
Fawzi Mahomoodally, Shanoo Suroowan
Common auto-inflammatory disorders (CAIDs) induce considerable suffering over the world. A panoply of synthetic medications areis available for theirits management. Nonetheless, available drug classes are limited by adverse effects, low systemic absorption, and high costs. In addition, no cure exists for most CAIDs. Interestingly, herbal products present a tremendous potential for development as anti-inflammatory agents. In this endeavor, major scientific databases; Google Scholar, Pubmed, ScienceDirect, and Scopus were explored to highlight novel therapeutic approaches using herbal products for CAIDs prophylaxis, management, treatment, and prevention of relapse...
February 12, 2018: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29434992/salvianolic-acid-b-suppresses-cell-proliferation-and-induces-apoptosis-in-osteosarcoma-through-p38-mediated-reactive-oxygen-species-generation
#12
Zhaoyang Zeng, Hua Zhang, Xin Wang, Kai Liu, Tian Li, Shaobo Sun, Hailong Li
The present study aimed to investigate the potential anticancer effect and mechanisms of salvianolic acid B on osteosarcoma. Salvianolic acid B suppressed osteosarcoma cell proliferation and induced apoptosis in the osteosarcoma MG63 cell line, and activated the expressions of cleaved caspase-3, phosphorylated-tumor protein (p)38 mitogen-activated protein kinase (p-p38 MAPK) and phosphorylated-p53 (p-p53) proteins in the MG63 cells. Additionally, Salvianolic acid B also increased the level of reactive oxygen species (ROS) generation in the MG63 cells...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433683/phytochemical-profile-of-orthosiphon-aristatus-extracts-after-storage-rosmarinic-acid-and-other-caffeic-acid-derivatives
#13
Lee Suan Chua, Cher Haan Lau, Chee Yung Chew, Nurul Izzati Mohd Ismail, Nitnipa Soontorngun
BACKGROUND: Orthosiphon aristatus (Blume) Miq. is a medicinal herb which is traditionally used for the treatment of diabetes and kidney diseases in South East Asia. Previous studies reported higher concentration of antioxidative phytochemicals, especially rosmarinic acid (ester of caffeic acid) and other caffeic acid derivatives in this plant extract than the other herbs such as rosemary and sage which are usually used as raw materials to produce rosmarinic acid supplement in the market...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29430840/screening-and-analysis-of-potential-active-components-in-shengxiong-glucose-injection-using-uhplc-coupled-with-photodiode-array-detection-and-ms-ms
#14
Meng Zhou, Rui Li, Xiang-Ming Liao, Zheng Wang, Guo-Bo Xu, Zi-Peng Gong, Yuan Lu, Xun He, Yong-Jun Li, Yong-Lin Wang, Lin Zheng, Shang-Gao Liao
Shengxiong glucose injection, a pharmaceutical preparation containing a water extract of the roots of Salvia miltiorrhizae and ligustrazine hydrochloride, is widely used in clinical to treat cardiovascular diseases in China. The chemical components of the water extract have been reported and the cardioprotective effects of the injection have been evaluated. However, the chemical constituents of the injection and their correlations with its pharmacological effects have not been established. In this study, thirteen chemical constituents of the injection have been identified or characterized by ultra high performance liquid chromatography with diode array detection and electrospray ionization quadrupole time-of-flight tandem mass spectrometry...
February 12, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29421539/salvianolic-acid-b-promotes-neural-differentiation-of-induced-pluripotent-stem-cells-via-pi3k-akt-gsk3%C3%AE-%C3%AE-catenin-pathway
#15
Tao Shu, Chang Liu, Mao Pang, Lei He, Bu Yang, Lei Fan, Shufan Zhang, Xuan Wang, Bin Liu, Limin Rong
Salvianolic acid B (Sal B), a water-soluble component mainly extracted from the traditional Chinese medicine Salvia miltiorrhiza, has potential anti-inflammatory, anti-oxidative and anti-apoptotic actions to protect neural cells. Here, we explore the effects and mechanisms of Sal B on the promotion of differentiation of induced pluripotent stem cells (iPSCs) into neural stem cells (NSCs), then further into neurons. During the processes of neural differentiation of iPSCs, Sal B or a phosphatidylinositide 3 kinase (PI3K) inhibitor (LY294002) were added to the medium...
February 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29401682/molecular-pharmacology-of-rosmarinic-and-salvianolic-acids-potential-seeds-for-alzheimer-s-and-vascular-dementia-drugs
#16
REVIEW
Solomon Habtemariam
Both caffeic acid and 3,4-dihydroxyphenyllactic acid (danshensu) are synthesized through two distinct routs of the shikimic acid biosynthesis pathway. In many plants, especially the rosemary and sage family of Lamiaceae, these two compounds are joined through an ester linkage to form rosmarinic acid (RA). A further structural diversity of RA derivatives in some plants such as Salvia miltiorrhiza Bunge is a form of RA dimer, salvianolic acid-B (SA-B), that further give rise to diverse salvianolic acid derivatives...
February 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29396922/simultaneous-determination-and-qualitative-analysis-of-six-types-of-components-in-naoxintong-capsule-by-miniaturized-matrix-solid-phase-dispersion-extraction-coupled-with-uhplc-with-photodiode-array-detection-and-q-tof-ms
#17
Huilin Wang, Yan Jiang, Mingya Ding, Jin Li, Jia Hao, Jun He, Hui Wang, Xiu-Mei Gao, Yan-Xu Chang
A simple and effective sample preparation process based on miniaturized matrix solid-phase dispersion was developed for simultaneous determination of phenolic acids (gallic acid, chlorogenic acid, ferulic acid, 3,5-dicaffeoylqunic acid, 1,5-dicaffeoylqunic acid, rosmarinic acid, lithospermic acid, salvianolic acid B), flavonoids (kaempferol-3-O-rutinoside, calycosin, formononetin), lactones (ligustilide, butyllidephthalide), monoterpenoids (paeoniflorin), phenanthraquinones (cryptotanshinone) and furans (5-hydroxymethylfurfural) in Naoxintong capsule by ultra high performance liquid chromatography...
February 3, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29384417/salvianolic-acid-a-ameliorates-renal-ischemia-reperfusion-injury-by-activating-akt-mtor-4ebp1-signaling-pathway
#18
Ying Song, Weihai Liu, Yi Ding, Yan-Yan Jia, Jinyi Zhao, Fan Wang, Juan Bai, Lianghua Cheng, Kai Gao, Meiyou Liu, Minna Yao, Liang Li, Yanmin Zhang, Aidong Wen, Langchong He
Salvianolic acid A (Sal A) has been shown to prevent and treat ischemic cardiovascular as well as cerebral vascular diseases. However, little is known about Sal A in renal ischemia/reperfusion (I/R) injury. In this study, a renal I/R injury model in rats and a hypoxia/reoxygenation (H/R) model to damage proximal renal tubular cells (HK-2) were used to assess whether Sal A halts the development and progression of renal I/R injury. As compared to vehicle treatment, Sal A significantly attenuated kidney injury and lowered plasma creatinine, blood urea nitrogen levels, the number of apoptosis-positive tubular cells, and kidney oxidative stress after renal I/R injury...
January 31, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29382534/salvianolic-acid-b-improves-airway-hyperresponsiveness-by-inhibiting-muc5ac-overproduction-associated-with-erk1-2-p38-signaling
#19
Yan Guan, Jian-Ping Zhu, Jian Shen, Yong-Liang Jia, Ya-Chao Jin, Xin-Wei Dong, Qiang-Min Xie
Salvianolic acid B (SalB) is one of the main water-soluble composites from Chinese medicine Dansen (Radix miltiorrhiza). It is used for clinical treatment of various diseases including cardiovascular, lung, Liver, renal and cancers. However, the effects of SalB to allergy induced airway mucin hypersecretion, inflammation and hyperresponsiveness (AHR) remains not clear. Overproduction of airway MUC5AC is a central effector of inflammation that is strongly associated with AHR in asthmatic attack. In this study, we investigated the anti-asthmatic activity and mechanism of SalB in a murine model and human epithelial cells by monitoring changes in mucin expression and secretion, airway inflammation, AHR, and signaling pathways...
January 27, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29349583/enhanced-production-of-phenolic-acids-in-cell-suspension-culture-of-salvia-leriifolia-benth-using-growth-regulators-and-sucrose
#20
Masoomeh Modarres, Sedigheh Esmaeilzadeh Bahabadi, Mohammad Ehsan Taghavizadeh Yazdi
Salvia leriifolia Benth. (Lamiaceae) is an endangered medicinal plant with hypoglycemic, anti-inflammatory and analgesic properties. Many of the beneficial effects of Salvia spp. are attributed to the phenolic compounds. In the present study, an efficient procedure has been developed for establishment of cell suspension culture of S. leriifolia as a strategy to obtain an in vitro phenolic acids producing cell line for the first time. The effect of growth regulators and various concentrations of sucrose have been analyzed, to optimize biomass growth and phenolic acids production...
April 2018: Cytotechnology
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