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Salvianolic acid B

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https://www.readbyqxmd.com/read/28636082/salvianolic-acid-b-protects-against-acute-lung-injury-by-decreasing-trpm6-and-trpm7-expressions-in-a-rat-model-of-sepsis
#1
Chu-Wei Yang, Hui Liu, Xiang-Dong Li, Shao-Guang Sui, Yu-Fei Liu
This study aimed to investigate the protective effects of salvianolic acid B (SA-B) on acute lung injury (ALI) through decreasing the expressions of channel kinase's TRPM6 and TRPM7. Wistar Septic rat models were established by lipopolysaccharide (LPS), which were separated into the control, lipopolysaccharide (LPS), SA-B, SA-B + si-TRPM6, SA-B + si-TRPM7, si-TRPM6 and si-TRPM7 groups. Arterial blood gas, protein content, total white blood cell (WBC) count and the percentage of polymorphonuclear neutrophils (PMN%) were measured...
June 21, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28603997/inhibition-of-human-ugt1a1-mediated-bilirubin-glucuronidation-by-polyphenolic-acids-impact-safety-of-popular-salvianolic-acid-a-b-containing-drugs-and-herbal-products
#2
Guo Ma, Ying Zhang, Wenyan Chen, Zhifang Tang, Xiaoming Xin, Ping Yang, Xiaoqin Liu, Weimin Cai, Ming Hu
Bilirubin-related adverse reactions (ADR, e.g., jaundice and hyperbilirubinemia) induced by herbs rich in certain polyphenolic acids are widely reported. However, the causes and the mechanisms underlying these ADR are not well understood. The purpose of this article is to determine the mechanism by which certain polyphenolic acids inhibit UGT1A1-mediated bilirubin glucuronidation, leading to jaundice or hyperbilirubinemia. We investigated in vitro inhibitory effects on bilirubin glucuronidation of salvianolic acid A (SAA), salvianolic acid B (SAB), danshensu (DSS), protocatechuic aldehyde (PA), and rosmarinic acid (RA), as well as two Salvia miltiorrhiza injections (DSI and CDI) rich in polyphenolic acids...
June 22, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28580904/fabrication-of-core-shell-nanofibers-for-controlled-delivery-of-bromelain-and-salvianolic-acid-b-for-skin-regeneration-in-wound-therapeutics
#3
Ekambaram Shoba, Rachita Lakra, Manikantan Syamala Kiran, Purna Sai Korrapati
The physiological and pathological complexity of the wound healing process makes it more challenging to design an ideal tissue regeneration scaffold. Precise scaffolding with high drug loading efficiency, efficient intracellular efficacy for therapeutic delivery, minimal nonspecific cellular and blood protein binding, and maximum biocompatibility forms the basis for an ideal delivery system. This paper describes a combinational multiphasic delivery system, where biomolecules are delivered through the fabrication of coaxial electrospinning of different biocompatible polymers...
June 5, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28513773/attenuation-of-renal-ischemic-reperfusion-injury-by-salvianolic-acid-b-via-suppressing-oxidative-stress-and-inflammation-through-pi3k-akt-signaling-pathway
#4
Z G Ma, H Q Xia, S L Cui, J Yu
Salvianolic acid B (SAB) is one the major phytocomponents of Radix Salvia miltiorrhiza and exhibit numerous health promoting properties. The objective of the current study was to examine whether SAB exerts a renoprotective effect by attenuating oxidative stress and inflammatory response through activating phosphatidylinositol 3-kinase/serine-threonine kinase B (PI3K/Akt) signaling pathway in a renal ischemic reperfusion rat model. Forty Sprague-Dawley male rats (250-300 g) were obtained and split into four groups with ten rats in each group...
May 15, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28495616/salvianolic-acid-b-attenuates-doxorubicin-induced-er-stress-by-inhibiting-trpc3-and-trpc6-mediated-ca-2-overload-in-rat-cardiomyocytes
#5
Rong-Chang Chen, Gui-Bo Sun, Jing-Xue Ye, Jian Wang, Miao-di Zhang, Xiao-Bo Sun
Doxorubicin (DOX)-induced cardiotoxicity is a clinically complex syndrome that leads to significant pain to cancer survivors. Endoplasmic reticulum (ER) stress has been suggested to be an important contributor to myocardium dysfunction during this phenomenon. Our previous study proved that Salvianolic acid B (Sal B) protected against doxorubicin induced cardiac dysfunction by inhibiting ER stress and cardiomyocyte apoptosis. However, the underlying molecular mechanism is not yet clearly. In this study, we investigated the protective effect and mechanisms of Sal B againest DOX-induced cardiac injury and ER stress in vivo and in vitro...
July 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28477086/effects-of-salvianolic-acid-b-on-l-type-calcium-channels-and-myocardial-contractility-in-isolated-rat-ventricular-myocytes-and-herg-k-channels-expressed-in-hek293-cells
#6
Qiongtao Song, Xue Han, Yuchong Xue, Tao Song, Xi Chu, Xuan Zhang, Yuanyuan Zhang, Ying Zhang, Jianping Zhang, Li Chu
Salvianolic acid B (Sal B), one of the chief water-soluble constituents in Radix Salviae Milthiorrhizae, has often been reported to possess considerable cardiovascular regulatory effects. However, the underlying biochemical and cellular mechanisms of its cardioprotection remain unclear. This study was designed to evaluate the role of Sal B regulation in L-type Ca(2+) channel currents (ICa,L) and cell contractility in rat cardiomyocytes and hERG K(+) channels expressed in HEK293 cells with the patch-clamp and Ca(2+) imaging techniques to clarify its underlying cardioprotective mechanisms...
May 5, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28475366/minor-compounds-of-the-high-purity-salvianolic-acid-b-freeze-dried-powder-from-salvia-miltiorrhiza-and-antibacterial-activity-assessment
#7
Junliang Zhang, Xue Zhang, Jianbin Zhang, Moying Li, Daijie Chen, Tong Wu
The study explored the isolation and characterisation of three compounds of high purity salvianolic acid B freeze-dried powder extracted from Salvia miltiorrhiza Bunge. A new salvianolic acid, salvianolic acid V (2) together with two known compounds (3-4) was identified. The antibacterial activity tests showed that compound 2 combined with clinical antibiotics such as Levofloxacin or Colistin sulphate together exhibited potent effects against MRSA or Acinetobacter baumanii. This report has considerably extended our knowledge about the diversity and bioactivity of caffeic acid derivatives from S...
May 5, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28413985/salvianolic-acid-b-decreases-the-generation-of-amyloid-%C3%AE-by-modulating-bace1-activity
#8
Siva Sundara Kumar Durairajan, Venkat Reddy Chirasani, Sravan Gopalakrishnan Shetty, Ashok Iyaswamy, Sandeep Malampati, Juxian Song, Liangfeng Liu, Jiandong Huang, Sanjib Senapati, Min Li
Generation and accumulation of the amyloid-β (Aβ) peptide after proteolytic processing of the full length amyloid precursor protein (FL-APP) by β-secretase (β-site APP cleaving enzyme or BACE1) and β -secretase is a main causal factor of Alzheimer's disease (AD). Thus, inhibition of BACE1, a rate-limiting enzyme in the production of Aβ, is an attractive therapeutic approach for the treatment of AD. Recent studies suggest that salvianolic acid B (Sal B) isolated from the radix of Salvia miltiorrhiza Bunge, a Chinese herbal medicine commonly used for the treatment of cardiovascular, cerebrovascular and liver diseases in China...
April 17, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28396195/treatment-with-salvianolic-acid-b-restores-endothelial-function-in-angiotensin-ii-induced-hypertensive-mice
#9
Wei Chih Ling, Jian Liu, Chi Wai Lau, Dharmani Devi Murugan, Mohd Rais Mustafa, Yu Huang
Salvianolic acid B (Sal B) is one of the most abundant phenolic acids derived from the root of Danshen with potent anti-oxidative properties. The present study examined the vasoprotective effect of Sal B in hypertensive mice induced by angiotensin II (Ang II). Sal B (25mg/kg/day) was administered via oral gavage for 11days to Ang II (1.2mg/kg/day)-infused C57BL/6J mice (8-10weeks old). The vascular reactivity (both endothelium-dependent relaxations and contractions) in mouse arteries was examined by wire myography...
July 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28391277/lincrna-p21-inhibits-the-wnt-%C3%AE-catenin-pathway-in-activated-hepatic-stellate-cells-via-sponging-microrna-17-5p
#10
Fujun Yu, Yong Guo, Bicheng Chen, Liang Shi, Peihong Dong, Mengtao Zhou, Jianjian Zheng
BACKGROUND/AIMS: It is known that the activation of hepatic stellate cells (HSCs) is a pivotal step in the initiation and progression of liver fibrosis. Aberrant activated Wnt/β-catenin pathway is known to accelerate the development of liver fibrosis. microRNAs (miRNAs)-mediated Wnt/β-catenin pathway has been reported to be involved in HSC activation during liver fibrosis. However, whether long noncoding RNAs (lncRNAs) regulate Wnt/β-catenin pathway during HSC activation still remains unclear...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28381679/synthesis-and-biological-evaluation-of-danshensu-and-tetramethylpyrazine-conjugates-as-cardioprotective-agents
#11
Yingfei Wang, Xiaojing Zhang, Changjiang Xu, Gaoxiao Zhang, Zaijun Zhang, Pei Yu, Luchen Shan, Yewei Sun, Yuqiang Wang
Myocardial ischemia is a primary cause of sudden death worldwide. Numerous active ingredients of traditional Chinese medicines including danshensu (DSS) and tetramethylpyrazine (TMP) have been widely used for the treatment of myocardial ischemia. To enhance their therapeutic efficacy and improve their drugability, in this work, we designed new DSS and TMP conjugates. Their water solubility and protective effects were studied in vitro and in experimental animal models. The new compounds demonstrated higher activities than the positive control agents acetylated danshensu and tetramethylpyrazine conjugate (ADTM) and salvianolic acid B (SAB) in preventing cells from oxidative insult...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28372153/synthesis-and-study-the-properties-of-stnps-gum-nanoparticles-for-salvianolic-acid-b-oral-delivery-system
#12
Xiaojing Li, Shengju Ge, Jie Yang, Ranran Chang, Caifeng Liang, Liu Xiong, Mei Zhao, Man Li, Qingjie Sun
To fabricate stable sized and shaped controlled release delivery systems for salvianolic acid B (Sal B), different food gums were individually added to short-chain glucan solution to prepare starch nanoparticles (StNPs)/gum nanocomposites by self-assembly, and Sal B was embedded in situ. The results showed that size of StNPs was reduced to ca. 45nm with the addition of chitosan and rosin, which decreased by over 50% than that of StNPs without the gum. The StNPs/guar gum nanocomposites had the largest size (109...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28364700/pharmacokinetic-study-of-representative-anti-oxidative-compounds-from-denshen-chuanxiong-honghua-following-oral-administration-in-rats
#13
Xianhua Zhang, Wan Zheng, Huali Xu, Xi Huang, Ping Ren, Hui Zou, Guihua Liu, Jian Wang, Xinliang Ma
Almost no pharmacokinetic compounds to date have been precisely linked with the activity of their herbal or Traditional Chinese Medicine (TCM) formula. This creates challenges for pharmacokinetic significance and application of the TCM. In our study, a sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to quantitatively or qualitatively determine multiple-components (tanshinol, ferulic acid, protocatechuic acid, rosmarinic acid, salvianolic acid B, baicalin and 9'-methyl lithospermate B) in rat plasma following the oral administration of Denshen-Chuanxiong-Honghua (DCH) extract (20g/kg)...
May 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28353641/rapid-determination-of-30-polyphenols-in-tongmai-formula-a-combination-of-puerariae-lobatae-radix-salviae-miltiorrhizae-radix-et-rhizoma-and-chuanxiong-rhizoma-via-liquid-chromatography-tandem-mass-spectrometry
#14
Fu-Rong Wang, Ying Zhang, Xin-Bao Yang, Chun-Xu Liu, Xiu-Wei Yang, Wei Xu, Jian-Xun Liu
Tongmai formula (TMF) is a herbal preparation composed of three traditional Chinese medicinal materials: Puerariae Lobatae Radix (Gegen), Salviae Miltiorrhizae Radix et Rhizoma (Danshen) and Chuanxiong Rhizoma (Chuanxiong). It has been used to treat cardiovascular diseases for decades. To develop a reliable and convenient analytical method for a comprehensive determination of polyphenols in TMF and the ascertainment of their chemical correlations with its herbal components, a method combining high-performance liquid chromatography with electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) was developed and validated for rapid determination of 30 polyphenols in TMF and its three herbal components...
March 29, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28352346/salvianolic-acid-b-prevents-steroid-induced-osteonecrosis-of-the-femoral-head-via-ppar%C3%AE-expression-in-rats
#15
Shuangqing Li, Juan Wang
Salvianolic acid B (Sal B) is a water-soluble phenolic compound derived from Salvia Miltiorrhiza. Recent studies show Sal B has a clear function of anti-cerebral ischemia injury, which is closely related to antioxidation, free radical scavenging, neuroprotection and the blood brain barrier. The aim of the present study was to verify whether Sal B prevents steroid-induced osteonecrosis of the femoral head and to investigate its underlying pharmacological mechanisms. Steroid-induced osteonecrosis rat models were established to evaluate the effects of Sal B on osteonecrotic changes and repair processes...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28335383/a-biomedical-investigation-of-the-hepatoprotective-effect-of-radix-salviae-miltiorrhizae-and-network-pharmacology-based-prediction-of-the-active-compounds-and-molecular-targets
#16
Ming Hong, Sha Li, Ning Wang, Hor-Yue Tan, Fan Cheung, Yibin Feng
Radix salviae miltiorrhizae (Danshen in Chinese), a classic traditional Chinese medicine (TCM) herb, has been used for centuries to treat liver diseases. In this study, the preventive and curative potential of Danshen aqueous extract on acute/chronic alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) was studied. The in vivo results indicated that Danshen could alleviate hepatic inflammation, fatty degeneration, and haptic fibrogenesis in ALD and NAFLD models. In the aspect of mechanism of action, the significant reduction in MDA levels in both ALD and NAFLD models implies the decreased levels of oxidative stress by Danshen...
March 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28326703/-effects-of-salvianolic-acid-b-on-osteogenic-differentiation-of-human-periodontal-ligament-cells
#17
Ma Yue, Ren Aishu, Fu Gang
OBJECTIVE: This study investigated the effects of salvianolic acid B (Sal B), a major bioactive component of the Chinese medicine salvia miltiorrhiza, on osteogenic differentiation of human periodontal ligament cells (hPDLCs). METHODS: Third passage PDLCs were used in this experiment. Methyl thiazolyl tetrazolium (MTT) method was employed to observe the effects of different Sal B concentrations on proliferation activity of hPDLCs. Alkaline phosphatase (ALP) activity and mineralization capability were measured, and mRNA expression of osteocalcin (OCN) was detected to investigate the effects of Sal B on osteogenesis of hPDLCs...
October 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28254683/salvianolic-acid-b-inhibits-il-1%C3%AE-induced-inflammatory-cytokine-production-in-human-osteoarthritis-chondrocytes-and-has-a-protective-effect-in-a-mouse-osteoarthritis-model
#18
Yiting Lou, Chenggui Wang, Wenhao Zheng, Qian Tang, Yu Chen, Xiaolei Zhang, Xiaoshan Guo, Jianshun Wang
Osteoarthritis (OA) is a chronic progressive disease that has complicated mechanisms that involve inflammation and cartilage degradation. In this study, we investigated the anti-inflammatory action of Salvianolic acid B (Sal B) in both human OA chondrocytes and a mouse OA model that was induced by destabilization of the medial meniscus. In vitro, chondrocytes were pretreated with Sal B (0, 25, 50, 100μM) for 2h, then incubated with IL-1β (10ng/mL) for 24h. NO production was determined by Griess method and PGE2 was assessed by ELISA...
May 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28251987/salvianolic-acid-b-inhibits-mitochondrial-dysfunction-by-up-regulating-mortalin
#19
Yunxia Liu, Yingying Hu, Qiukai E, Ji Zuo, Ling Yang, Wen Liu
Salvianolic acid B is an antioxidative ingredient derived from Radix Salviae miltiorrhizae that has been widely used to treat liver diseases. However, the therapeutic mechanism underlying Salvianolic acid B has remained largely unknown. Our studies verified that Salvianolic acid B efficiently blocked mitochondrial deformation and dysfunction induced by H2O2 in the human hepatocyte cell line HL7702. Mortalin, a mitochondrial molecular chaperone, maintains mitochondrial morphology stabilization and function integrity...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28244648/salvianolic-acid-b-regulates-gene-expression-and-promotes-cell-viability-in-chondrocytes
#20
Xiaohong Yang, Shaojie Liu, Siming Li, Pengzhen Wang, Weicong Zhu, Peihong Liang, Jianrong Tan, Shuliang Cui
Articular chondrocytes reside in lacunae distributed in cartilage responsible for the remodelling of the tissue with limited ability of damage repairing. The in vitro expanded chondrocytes enhanced by factors/agents to obtain large numbers of cells with strengthened phenotype are essential for successful repair of cartilage lesions by clinical cell implantation therapies. Because the salvianolic acid B (Sal B), a major hydrophilic therapeutic agent isolated from Salvia miltiorrhiza, has been widely used to treat diseases and able to stimulate activity of cells, this study examines the effects of Sal B on passaged chondrocytes...
February 28, 2017: Journal of Cellular and Molecular Medicine
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