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Salvianolic acid B

Yang Lv, Bo Liu, Yuan Liu, Haoyu Wang, Haiping Wang
Transforming growth factor β1 (TGF-β1) and salvianolic acid B (Sal-B) are key signaling factors for stem cell differentiation into cardiomyocytes (CMs). The present study compared the biological effect of TGF-β1 and Sal-B, alone or in combination, on bone marrow mesenchymal stromal cells (BMSCs) that differentiate into myocardial-like cells in a simulated myocardial microenvironment in vitro . BMSCs were isolated from bones of limbs of 10 male Sprague Dawley rats and cultured. The 2nd-generation BMSCs were co-incubated with TGF-β1 and Sal-B, alone or in combination, for 72 h...
June 2018: Experimental and Therapeutic Medicine
Xinrui Xing, Si Chen, Ling Li, Yan Cao, Langdong Chen, Xiaobo Wang, Zhenyu Zhu
Purpose: This study aimed to identify the active components of Fuzheng Huayu (FZHY) formula and the mechanism by which they inhibit the viability of hepatic stellate cells (HSCs) by a combination of network pharmacology and transcriptomics. Methods: The active components of FZHY formula were screened out by text mining. Similarity match and molecular docking were used to predict the target proteins of these compounds. We then searched the STRING database to analyze the key enriched processes, pathways and related diseases of these target proteins...
2018: Frontiers in Pharmacology
Piaoting Guo, Jianchao Wang, Wencang Gao, Xia Liu, Shaofei Wu, Boshun Wan, Lei Xu, Yanhua Li
Salvianolic acid B (SalB) is a water‑soluble phenolic compound, extractable from Salvia miltiorrhiza, and has previously been demonstrated to reverse tumor multidrug resistance (MDR) in colon cancer cells. Cancer stem cells (CSCs) are closely associated with drug resistance. Therefore, establishing a nude mouse model bearing human colon CSCs is important for the study of the mechanisms underlying colon cancer drug resistance as well as the reversal of drug resistance. The present study aimed to establish a nude mouse model bearing human colon CSCs and to investigate the effects of SalB on the drug resistance exhibited by the nude mouse model as well as determine its underlying mechanism...
May 29, 2018: Molecular Medicine Reports
Xuyang Liu, Zhan-Guo Gao, Yiran Wu, Raymond C Stevens, Kenneth A Jacobson, Suwen Zhao
Many hemorheologic Traditional Chinese Medicines (TCMs) that are widely-used clinically lack molecular mechanisms of action. We hypothesized that some of the active components of hemorheologic TCMs may function through targeting prothrombotic P2Y1 and/or P2Y12 receptors. The interactions between 253 antithrombotic compounds from TCM and these two G protein-coupled P2Y receptors were evaluated using virtual screening. Eleven highly ranked hits were further tested in radioligand binding and functional assays...
May 24, 2018: Scientific Reports
Jie Wei, Jun Wu, Wen Xu, Hong Nie, Ruiqing Zhou, Rui Wang, Yang Liu, Guoyao Tang, Jianyong Wu
Our previous study demonstrated a progressive glycolytic perturbation during the course of DMBA-induced hamster oral carcinogenesis, which was attenuated by salvianolic acid B (Sal-B) treatment along with decreased incidences of oral squamous cell carcinoma (OSCC) formation. It was proposed that metabolic modulation should be an additional mode of action attributable to Sal-B's anti-carcinogenic activity. However, the molecular mechanisms underlying Sal-B-induced metabolic modulation function remained elusive...
May 22, 2018: Cell Death & Disease
Wei-Jing Yun, Zhi-Hong Yao, Cai-Lian Fan, Zi-Fei Qin, Xi-Yang Tang, Meng-Xue Gao, Yi Dai, Xin-Sheng Yao
Qi-Li-Qiang-Xin capsule (QLQX), a well-known traditional Chinese medicine prescription (TCMP), is consisted of eleven commonly used herbal medicines, has been widely used for the treatment of chronic heart failure (CHF). However, the absorbed components and related metabolites after oral administration of QLQX are still remaining unknown. In the present work, a reliable and effective method using ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS) was established to identify QLQX-related xenobiotics in rats...
May 12, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Haizhu Kuang, Yao Wang, Junfeng Hu, Chunsheng Wang, Shuyang Lu, Xiumei Mo
Studies have shown that traditional Chinese medicine Salvianolic acid B (SAB) can promote the proliferation and migration of endothelial cells. Heparin has a good anticoagulant effect. The inner layer of artificial vascular graft is fabricated by coaxial electrospinning method, and loaded with heparin and SAB. The release of heparin and SAB was sustained for almost 30 days, and SAB without initial burst release. Furthermore, the combined effect of SAB and heparin contributed to promoted Human Umbilical Vein Endothelial Cells (HUVECs) growth and improved blood compatibility of graft...
May 21, 2018: ACS Applied Materials & Interfaces
D Luo, Y X Zhao, Y H Zhang, Y Zhou, J Ding, Z F Sun
Objective: The aim of this study is to discuss the effects and mechanism of salvianolic acid B (SAB) on the proliferation and apoptosis of human nasal polyps fibroblasts (NPFs). Method: The NPFs were treated with SAB at different concentrations (5, 10, 20, 40 μmol/L). CCK-8 assay was used to determine the inhibition of SAB on the proliferation of NPFs and determined the optimum concentration for the following experiments. The NPFs were divided into four groups: a) control group: the cells were cultured in DMEM without TGF-β1 or salvianolic acid B; b) the TGF-β1 group: the cells were cultured in DMEM containing 5 ng/ml TGF-β1; c) the SAB group: the cells were cultured in DMEM containing SAB at the optimum concentration by CCK-8 assay; d) the TGF-β1+SAB treatment groups: the cells were cultured in DMEM containing 5 ng/ml TGF-β1 and SAB at the optimum concentration by CCK-8 assay...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Haimei Liu, Shuli Ma, Hongrui Xia, Hongxiang Lou, Faliang Zhu, Longru Sun
ETHNOPHARMACOLOGICAL RELEVANCE: The roots of Salvia miltiorrhiza f. alba (Lamiaceae) (RSMA) are used as the Danshen, a traditional Chinese medicine, to treat the vascular diseases at local clinics, especially for the remedy of thromboangiitis obliterans (TAO) more than 100 years. Phenolic acids are one of the major effective constituents of RSMA, and some studies have linked phenolic acids with anti-inflammatory functions. AIM OF THE STUDY: The purpose of this research was to isolate phenolic acids from RSMA and investigate their anti-inflammatory effects and potential mechanisms...
May 8, 2018: Journal of Ethnopharmacology
Min Shi, Fenfen Huang, Changping Deng, Yao Wang, Guoyin Kai
Salvia miltiorrhiza (Danshen in Chinese), is a well-known traditional Chinese medicinal plant, which is used as not only human medicine but also health-promotion food. Danshen has been extensively used for the treatment of various cardiovascular and cerebrovascular diseases. As a major group of bioactive constituents from S. miltiorrhiza, water-soluble phenolic acids such as salvianolic acid B possessed good bioactivities including antioxidant, anti-inflammatory, anti-cancer and other health-promoting activities...
May 10, 2018: Critical Reviews in Food Science and Nutrition
Yu-Qing Wang, Guo Zhuang, Shu-Jiao Li
Yudanshen, the genuine medicinal materials of Danshen (Salvia miltiorrhiza), is a well-known traditional Chinese medicine (TCM) used to treat cardiovascular and cerebrovascular diseases. Although its pharmacological and antioxidative activities have been well-documented, there is little research on the hydroxyl radical (OH) scavenging capacity of Yudanshen. In this study, we established multiple on-line high-performance liquid chromatography- chemiluminescence detector-diode-quadrupole-time of flight mass spectrometry (HPLC-CL-DAD-Q-TOF/MS) methods to rapidly screen and identify the OH scavengers in Yudanshen simultaneously...
April 27, 2018: Journal of Pharmaceutical and Biomedical Analysis
Cun-Yu Li, Xin Wu, Jia-Mei Gu, Hong-Yang Li, Guo-Ping Peng
Based on the molecular sieving and solution-diffusion effect in nanofiltration separation, the correlation between initial concentration and mass transfer coefficient of three typical phenolic acids from Salvia miltiorrhiza was fitted to analyze the relationship among mass transfer coefficient, molecular weight and concentration. The experiment showed a linear relationship between operation pressure and membrane flux. Meanwhile, the membrane flux was gradually decayed with the increase of solute concentration...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Si-Qi Wu, Hui-Peng Song, Bin Li, Run-Zhou Liu, Hua Yang, Ling He, Ping Li
Development of fast and accurate methods to discover lead compounds for drug candidates is highly important. In this study, a reliable and effective post-column on-flow biochemical assay (POBA) was established to screen potent peroxidase inhibitors from complex chemical mixtures (e.g., natural product extracts). Multiple factors such as flow rate, organic phase, detection wavelength, and reaction coil were carefully investigated. To better understand the features of POBA, another emerging technology of ultrafiltration LC-MS was used for comparison...
May 3, 2018: Analytical and Bioanalytical Chemistry
Xin Shao, Jie Zhao, Xu Wang, Yi Tao
Qing-Hua-Yu-Re-Formula (QHYRF), a new herbal preparation, has been extensively used for treating diabetic cardiomyopathy. However, the chemical constituents of QHYRF remain uninvestigated. In the present study, rapid ultrahigh-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) was used to qualitatively analyze the components of QHYRF. Qualitative detection was performed on a Kromasil C18 column through the gradient elution mode, using acetonitrile-water containing 0...
2018: Journal of Analytical Methods in Chemistry
Catarina L Lopes, Eliana Pereira, Marina Soković, Ana Maria Carvalho, Ana Maria Barata, Violeta Lopes, Filomena Rocha, Ricardo C Calhelha, Lillian Barros, Isabel C F R Ferreira
The aim of this study was to characterize the phenolic composition and evaluate the bioactivity of several samples of Lavandula pedunculata (Mill.) Cav, and to compare aqueous and hydroethanolic extracts. Plant materials were obtained by growing some accessions (seed samples) of various wild populations from different regions of Portugal conserved at the Portuguese Genebank in Braga. Phenolic compounds were analised by HPLC-DAD-ESI/MSn, antioxidant potential through in vitro assays (DPPH radical scavenging activity, reducing power and inhibition of lipid peroxidation), cytotoxicity on tumor cells (MCF-7, NCI-H460, HeLa and HepG2) and non-tumor (PLP2) cells, anti-inflammatory activity in rat RAW 264...
April 28, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Ing-Gin J Chen, Meng-Shiou Lee, Ming-Kuem Lin, Chia-Yun Ko, Wen-Te Chang
The effect of light-emitting diodes (LEDs) on the production of secondary metabolites in medicinal plants and hairy roots is receiving much attention. The roots and rhizomes of the traditional Chinese medicinal plant Salvia miltiorrhiza Bunge are widely used for treating cardiovascular and cerebrovascular diseases. The main components are liposoluble tanshinones and hydrophilic phenolic acids. Moreover, hairy root culture of S. miltiorrhiza has been used in research of valuable plant-derived secondary metabolites...
June 2018: Journal of Photochemistry and Photobiology. B, Biology
Fugeng Zhang, Yu Zhang, Xiaofeng Li, Shaoqiang Zhang, Mingdan Zhu, Wuxun Du, Xuefeng Xiao
BACKGROUND: Qiliqiangxin capsule (QLQX), composed of 11 herbs, is an effective traditional Chinese medicine (TCM) that has been widely used for treatment of chronic heart failure (CHF) in China. In the Chinese pharmacopoeia (Ch.P.) only astragaloside was described as the marker component to control the quality of QLQX, which could not reflect the overall effectiveness. PURPOSE: The aim of this work was to investigate the quality markers (Q-markers) of QLQX based on the association of the pharmacodynamics (PD) of inhibitory effect on activated renin-angiotensin-aldosterone system (RAAS) and the pharmacokinetics (PK) of bioactive compounds according to the Q-marker theory...
May 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Zhuo-Ming Li, Suo-Wen Xu, Pei-Qing Liu
Salvia miltiorrhiza Burge (Danshen) is an eminent medicinal herb that possesses broad cardiovascular and cerebrovascular protective actions and has been used in Asian countries for many centuries. Accumulating evidence suggests that Danshen and its components prevent vascular diseases, in particular, atherosclerosis and cardiac diseases, including myocardial infarction, myocardial ischemia/reperfusion injury, arrhythmia, cardiac hypertrophy and cardiac fibrosis. The published literature indicates that lipophilic constituents (tanshinone I, tanshinone IIa, tanshinone IIb, cryptotanshinone, dihydrotanshinone, etc) as well as hydrophilic constituents (danshensu, salvianolic acid A and B, protocatechuic aldehyde, etc) contribute to the cardiovascular protective actions of Danshen, suggesting a potential synergism among these constituents...
May 2018: Acta Pharmacologica Sinica
Zeng-Bing Xia, Yong-Jian Yuan, Qiang-Hua Zhang, Heng Li, Ji-Lin Dai, Ji-Kang Min
BACKGROUND Salvianolic acid B (SB) is a major active phyto-component of the plant Radix Salvia miltiorrhiza, which is traditionally used to treat joint pain and arthritis. The present study examined the anti-rheumatoid arthritis efficacy of SB on collagen-induced rheumatoid arthritis (CIA) in a rat model. MATERIAL AND METHODS Forty-eight rats were divided into 4 groups: Control rats treated with saline (Group I), rats subjected to CIA induction by intradermal injection of bovine collagen II type at the tail (Group II), and rats subjected to CIA and supplemented with either 20 or 40 mg/kg of SB for 28 days (group III or IV)...
April 25, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Sien Lin, Liao Cui, Guanghua Chen, Jianping Huang, Yanhua Yang, Kaijie Zou, Yuxiao Lai, Xinluan Wang, Liyi Zou, Tie Wu, Jack Chun Yiu Cheng, Gang Li, Bo Wei, Wayne Yuk Wai Lee
Spinal disorders often require surgical treatment called spinal fusion to restore a stabilized spine where bone grafts are implanted for the fusion of adjacent vertebras. In this study, we developed a bioactive composite scaffold incorporated with salvianolic acid B (SB), an active component extracted from Danshen. This study aimed to evaluate the effects of SB-incorporated porous scaffold on spinal fusion models. The composite scaffolds composed of poly (lactic-co-glycolic acid) and tricalcium phosphate (PLGA/β-TCP) were fabricated with low-temperature rapid prototyping technique, which incorporated SB at low (SB-L), middle (SB-M), high (SB-H) doses, and pure PLGA/β-TCP as blank control (Con)...
April 4, 2018: Biomaterials
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