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Salvianolic acid B

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https://www.readbyqxmd.com/read/27893819/salvianolic-acid-b-alleviates-heart-failure-by-inactivating-erk1-2-gata4-signaling-pathway-after-pressure-overload-in-mice
#1
Juan Yu, Renshan Chen, Yafang Tan, Jiashin Wu, Jianyong Qi, Minzhou Zhang, Weiwang Gu
BACKGROUND: Heart failure(HF) is a dangerous disease that affects millions of patients. Radix Salvia is widely used in Chinese clinics to treat heart diseases. Salvianolic acid B(SalB) is the major active component of Radix Salvia. This study investigated the mechanisms of action and effects of SalB on HF in an experimental mouse model of HF. METHODS: We created a mouse model of HF by inducing pressure overload with transverse aortic constriction(TAC) surgery for 2 weeks and compared among 4 study groups: SHAM group (n = 10), TAC group (n = 9), TAC+MET group (metprolol, positive drug treatment, n = 9) and TAC+SalB group (SalB, 240 mg•kg-1•day-1, n = 9)...
2016: PloS One
https://www.readbyqxmd.com/read/27889668/drug-protein-binding-of-danhong-injection-and-the-potential-influence-of-drug-combination-with-aspirin-insight-by-ultrafiltration-lc-ms-and-molecular-modeling
#2
Junfeng Zhu, Xiaojiao Yi, Peng Huang, Shuqing Chen, Yongjiang Wu
Danhong injection (DHI) is a widely used Chinese medicine injection (CMI) for the clinical treatment of cardiovascular and cerebrovascular diseases. In this study, a simple and efficient in vitro method based on ultrafiltration LC-MS and molecular modeling has been developed to study the human serum albumin (HSA) binding of the compounds in DHI. Seven major components including protocatechuic aldehyde, p-coumaric acid, salvianolic acid D, rosmarinic acid, salvianolic acid E, lithospermic acid and salvianolic acid B were identified as HSA ligands and their binding degrees in the proposed non-saturated model were 26...
November 18, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27875788/simultaneous-determination-and-pharmacokinetic-study-of-four-phenolic-acids-in-rat-plasma-using-uflc-ms-ms-after-intravenous-administration-of-salvianolic-acid-for-injection
#3
Xiuman Xie, Jingzhuo Miao, Wanyang Sun, Jingyi Huang, Dongxiang Li, Shuming Li, Ling Tong, Guoxiang Sun
A simple, sensitive and selective ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method was established for simultaneous determination and pharmacokinetic study of rosmarinic acid (RA), salvianolic acid D (Sal D), lithospermic acid (LA) and salvianolic acid B (Sal B) in rat plasma after intravenous administration of salvianolic acid for injection (SAFI). Three doses of administration, containing 14, 28 and 56mg/kg, were investigated in this study. Plasma samples were pretreated using protein precipitation (PP) with pre-cooled acetonitrile...
November 5, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27866193/mixed-aqueous-extract-of-salvia-miltiorrhiza-reduces-blood-pressure-through-inhibition-of-vascular-remodelling-and-oxidative-stress-in-spontaneously-hypertensive-rats
#4
Jing Zhang, Sheng Jun An, Jun Qiu Fu, Pei Liu, Tie Mei Shao, Manli Li, Xue Li, Zhan Jiao, Xi Qing Chai
BACKGROUND/AIMS: Salvia miltiorrhiza (SM) contains four major aqueous active ingredients, which have been isolated, purified and identified as danshensu (DSS), salvianolic acid A (Sal-A), salvianolic acid B (Sal-B) and protocatechuic aldehyde (PAL), totally abbreviated as SABP. Although SM is often used to treat various cardiovascular diseases in traditional Chinese medicine, the efficacy and function of optimal compatibility ratio of SM's active ingredients (SABP) in the prevention and treatment of cardiovascular diseases remain uncertain...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27855406/scoparone-protects-against-pancreatic-fibrosis-via-tgf-%C3%AE-smad-signaling-in-rats
#5
Min Xu, Jing Cai, Hong Wei, Meng Zhou, Ping Xu, Hongmei Huang, Wanxin Peng, Fengyi Du, Aihua Gong, Youli Zhang
BACKGROUND/AIMS: This study was to investigate the influence of scoparone on pancreatic fibrosis in vitro and in vivo. METHODS: Pancreatic stellate cells (PSCs) were isolated from pancreas tissue blocks, and cultured for 3-5 generations for the experiment. PSCs were treated with scoparone in different doses as experimental groups, salvianolic acid B as a positive control and PBS as a blank group. We measured the effects of scoparone on cellular proliferation, oxidative stress, epithelial-mesenchymal transition (EMT), and pancreatic fibrosis...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27852325/salvianolic-acid-b-reduced-the-formation-of-epidural-fibrosis-in-an-experimental-rat-model
#6
Feng Chen, Changyao Wang, Jintang Sun, Jin Wang, Lanfeng Wang, Jianmin Li
BACKGROUND: Salvianolic acid B (Sal B) was newly reported to be able to attenuate fibrosis in the animal model. The aim of the present study was to investigate the effect of the intragastric application of Sal B on the prevention of epidural fibrosis (EF). METHODS: Forty healthy adult male Wistar rats were divided into four treatment groups (n = 10 per group): (1) 10 mg/kg Sal B, (2) 30 mg/kg Sal B, (3) 50 mg/kg Sal B and (4) Saline (vehicle treatment, control group)...
November 16, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27843313/salvianolic-acid-b-protects-against-myocardial-damage-caused-by-nanocarrier-tio2-and-synergistic-anti-breast-carcinoma-effect-with-curcumin-via-codelivery-system-of-folic-acid-targeted-and-polyethylene-glycol-modified-tio2-nanoparticles
#7
Lingling Ding, Jiawei Li, Rui Huang, Zhidong Liu, Chunhua Li, Shaozi Yao, Jinyan Wang, Dongli Qi, Nan Li, Jiaxin Pi
Targeted delivery by the folate ligand is an effective way to enhance an anti-breast carcinoma effect, due to its high affinity for the folate receptor, which is overexpressed in many tumor cells. In this study, we firstly synthesized a folic acid (FA)-targeted and polyethylene glycol (PEG)-modified TiO2 nanocarrier. Then, an FA-PEG-TiO2 nanoparticle (NP) codelivery system loaded with curcumin and salvianolic acid B were prepared by emulsion evaporation-solidification at low temperature. The obtained folate-targeted NPs (FA-NPs) showed more cytotoxicity on MCF7 cells and MDA-MB-231 cells than a nontargeted NP group...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27827892/salvianolic-acid-b-sal-b-protects-retinal-pigment-epithelial-cells-from-oxidative-stress-induced-cell-death-by-activating-glutaredoxin-1-grx1
#8
Xiaobin Liu, Christy Xavier, Jamieson Jann, Hongli Wu
Protein glutathionylation, defined as the formation of protein mixed disulfides (PSSG) between cysteine residues and glutathione (GSH), can lead to cell death. Glutaredoxin 1 (Grx1) is a thiol repair enzyme which catalyzes the reduction of PSSG. Therefore, Grx1 exerts strong anti-apoptotic effects by improving the redox state, especially in times of oxidative stress. However, there is currently no compound that is identified as a Grx1 activator. In this study, we identified and characterized Salvianolic acid B (Sal B), a natural compound, as a Grx1 inducer, which potently protected retinal pigment epithelial (RPE) cells from oxidative injury...
November 3, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27818233/systems-biology-dissection-of-mechanisms-and-chemical-basis-of-herbal-formula-in-treating-chronic-myocardial-ischemia
#9
Shuzhen Guo, Peng Li, Bangze Fu, Wenjing Chuo, Kuo Gao, Wuxia Zhang, Junyao Wang, Jianxin Chen, Wei Wang
Herbal medicine is a mixture of multiple compounds, and is intended to exhibit therapeutic effects by attacking multiple disease-causing modules simultaneously. However, it is still a challenge for scientists to untangle the complex biological mechanisms and underlying material basis of herbal medicine. Here, this study was designed to build a systems-biology platform for exploring the molecular mechanisms and corresponding active compounds, with a typical example applied to an herbal formula Qishenkel (QSKL) in the treatment of chronic myocardial ischemia...
November 3, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27779641/akt-mtor-signaling-pathway-is-involved-in-salvianolic-acid-b-induced-autophagy-and-apoptosis-in-hepatocellular-carcinoma-cells
#10
Ling Gong, Chunhong Di, Xiaofang Xia, Jie Wang, Gongying Chen, Junping Shi, Pengshuai Chen, Hui Xu, Weibing Zhang
Chinese medicines are emerging as an attractive new generation of anticancer drugs. Here, we explored the impact of salvianolic acid B (Sal B), the major water-soluble compounds of Danshen, on apoptosis and autophagy of human hepatocellular carcinoma cells (HCC). We also investigated the related molecular mechanisms. We found that Sal B exhibits potent ability to inhibit HCC cells viability in a concentration-dependent manner, and to induce apoptosis via the mitochondrial apoptosis pathway. Additionally, Sal B could also induce autophagy...
October 24, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27734327/pharmacokinetics-and-pharmacodynamics-of-promising-arginase-inhibitors
#11
Khaled S Abdelkawy, Kelsey Lack, Fawzy Elbarbry
Up-regulation of arginase activity in several chronic disease conditions, including cancer and hypertension, may suggest new targets for treatment. Recently, the number of new arginase inhibitors with promising therapeutic effects for asthma, cancer, hypertension, diabetes mellitus, and erectile dysfunction has shown a remarkable increase. Arginase inhibitors may be chemical substances, such as boron-based amino acid derivatives, α-difluoromethylornithine (DMFO), and Nω-hydroxy-nor-L-arginine (nor-NOHA) or, of plant origin such as sauchinone, salvianolic acid B (SAB), piceatannol-3-O-β-D-glucopyranoside (PG) and obacunone...
October 12, 2016: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27716647/immobilization-of-salvianolic-acid-b-loaded-chitosan-microspheres-distributed-three-dimensionally-and-homogeneously-on-the-porous-surface-of-hydroxyapatite-scaffolds
#12
Jinyu Li, Qin Wang, Wei Zhi, Jianxin Wang, Bo Feng, Shuxin Qu, Yandong Mu, Jie Weng
Porous hydroxyapatite (HA) scaffolds combined with a drug delivery system have attracted much attention for bone tissue engineering. In this study, an easy and highly efficient method was developed to immobilize salvianolic acid B (Sal B)-loaded chitosan (CS) microspheres three dimensionally and homogeneously on the surface of HA scaffolds pre-coated with alginate. Porous HA scaffolds were prepared via a template-leaching process and CS microspheres (used as drug carriers) were fabricated by an emulsion method...
October 7, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27700012/chemical-constituents-and-quality-control-of-two-dracocephalum-species-based-on-high-performance-liquid-chromatographic-fingerprints-coupled-with-tandem-mass-spectrometry-and-chemometrics
#13
Qi Li, Yiqi Liu, Lingfei Han, Jiazhuo Liu, Wenyuan Liu, Feng Feng, Jie Zhang, Ning Xie
Two similar Dracocephalum species, namely, Dracocephalum tanguticum Maxim and Dracocephalum moldavica L, are commonly used as ethnic medicines in China. Here we describe a strategy of combining high-performance liquid chromatography with quadrupole time-of-flight mass spectrometry, as well as fingerprints and chemometrics for characterization and discrimination of chemical constituents on the two herbs. A total of 49 compounds including 33 flavonoids, 5 phenylethanol glycosides, 1 coumarin glycoside, 8 organic acids, and 2 other types of compounds were unambiguously or tentatively identified from the two Dracocephalum species...
November 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27670752/preparation-of-salvianolic-acid-a-by-the-degradation-reaction-of-salvianolic-acid-b-in-subcritical-water-integrated-with-ph-zone-refining-counter-current-chromatography
#14
Huaizhi Li, Yan Cheng, Hongjing Dong, Xiao Wang, Jia Li, Qianshan Gao
Salvianolic acid A is the major bioactive compound in Danshen, however, due to the chemical instability and low content in Danshen, it is difficult to extract amount of salvianolic acid A. Therefore, this study was to establish an effective strategy for obtaining adequate amount of salvianolic acid A, subcritical water extraction was used to degrade salvianolic acid B and prepare salvianolic acid A. Different reaction conditions including temperature, time, concentration and pH value in subcritical water were investigated...
October 14, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27659301/anti-ageing-active-ingredients-from-herbs-and-nutraceuticals-used-in-traditional-chinese-medicine-pharmacological-mechanisms-and-implications-for-drug-discovery
#15
REVIEW
Chun-Yan Shen, Jian-Guo Jiang, Li Yang, Da-Wei Wang, Wei Zhu
Ageing, an unanswered question in the medical field, is a multifactorial process that results in a progressive functional decline in cells, tissues and organisms. Although it is impossible to prevent ageing, slowing down the rate of ageing is entirely possible to achieve. Traditional Chinese medicine (TCM) is characterized by the nourishing of life and its role in anti-ageing is getting more and more attention. This article summarizes the work done on the natural products from TCM that are reported to have anti-ageing effects, in the past two decades...
September 23, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27614410/synthesis-and-evaluation-of-xanthine-oxidase-inhibitory-and-antioxidant-activities-of-2-arylbenzo-b-furan-derivatives-based-on-salvianolic-acid-c
#16
Hong-Jin Tang, Xiao-Wei Zhang, Lin Yang, Wei Li, Jia-Huang Li, Jin-Xin Wang, Jun Chen
Xanthine oxidase (XO) is the key enzyme in humans which is related to a variety of diseases such as gout, hyperuricemia and cardiovascular diseases. In this work, a series of 2-arylbenzo[b]furan derivatives were synthesized based on salvianolic acid C, and they were evaluated for xanthine oxidase inhibitory and antioxidant activities. Compounds 5b, 6a, 6e and 6f showed potent xanthine oxidase inhibitory activities with IC50 values ranging from 3.99 to 6.36 μM, which were comparable with that of allopurinol...
August 31, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27614127/salvianolic-acid-b-improves-vascular-endothelial-function-in-diabetic-rats-with-blood-glucose-fluctuations-via-suppression-of-endothelial-cell-apoptosis
#17
Younan Ren, Shanjun Tao, Shuguo Zheng, Mengqiu Zhao, Yuanmei Zhu, Jieren Yang, Yuanjie Wu
Vascular endothelial cell injury is an initial event in atherosclerosis. Salvianolic acid B (Sal B), a main bioactive component in the root of Salvia miltiorrhiza, has vascular protective effect in diabetes, but the underlying mechanisms remain unclear. The present study investigated the effect of Sal B on vascular endothelial function in diabetic rats with blood glucose fluctuations and the possible mechanisms implicated. The results showed that diabetic rats developed marked endothelial dysfunction as exhibited by impaired acetylcholine induced vasodilation...
September 8, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27613617/function-analysis-of-caffeoyl-coa-o-methyltransferase-for-biosynthesis-of-lignin-and-phenolic-acid-in-salvia-miltiorrhiza
#18
Zhengjun Wang, Qian Ge, Chen Chen, Xinxin Jin, Xiaoyan Cao, Zhezhi Wang
In this study, we cloned a full-length cDNA and the genomic DNA sequence of SmCCoAOMT (GenBank ID JQ007585) from Salvia miltiorrhiza. The 744-bp open-reading frame encodes a protein of 247 amino acids that shares 95 % similarity with one in Vitis vinifera. Real-time quantitative PCR analysis revealed that SmCCoAOMT is most highly expressed in the stems and can be induced by methyl jasmonate (MeJA) and XC-1 treatment. To evaluate its function in vivo, we generated RNA interference transgenic plants through Agrobacterium tumefaciens-mediated gene transfer...
September 9, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27609227/salvianolic-acid-a-alleviates-ischemic-brain-injury-through-the-inhibition-of-inflammation-and-apoptosis-and-the-promotion-of-neurogenesis-in-mice
#19
Mei-Yin Chien, Cheng-Hung Chuang, Chang-Ming Chern, Kou-Tong Liou, Der-Zen Liu, Yu-Chang Hou, Yuh-Chiang Shen
Salvianolic acid A (SalA), a chemical type of caffeic acid trimer, has drawn great attention for its potent bioactivities against ischemia-induced injury both in vitro and in vivo. In this study, we evaluated SalA's protective effects against acute ischemic stroke by inducing middle cerebral artery occlusion/reperfusion (MCAO) injuries in mice. Treatment of the mice with SalA (50 and 100μg/kg, i.v.) at 2h after MCAO enhanced their survival rate, improved their moving activity, and ameliorated the severity of brain infarction and apoptosis seen in the mice by diminishing pathological changes such as the extensive breakdown of the blood-brain barrier (BBB), nitrosative stress, and the activation of an inflammatory transcriptional factor p65 nuclear factor-kappa B (NF-κB) and a pro-apoptotic kinase p25/Cdk5...
September 5, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27596830/qualitative-and-quantitative-analyses-of-compound-danshen-extract-based-on-1-h-nmr-method-and-its-application-for-quality-control
#20
Kai-Jing Yan, Yang Chu, Jian-Hua Huang, Miao-Miao Jiang, Wei Li, Yue-Fei Wang, Hui-Yong Huang, Yu-Hui Qin, Xiao-Hui Ma, Shui-Ping Zhou, Henry Sun, Wei Wang
In this study, a new approach using (1)H NMR spectroscopy combined with chemometrics method was developed for qualitative and quantitative analyses of extracts of Compound Danshen Dripping Pills (CDDP). For the qualitative analysis, some metabolites presented in Compound Danshen extract (CDE, extraction intermediate of CDDP) were detected, including phenolic acids, saponins, saccharides, organic acids and amino acids, by the proposed (1)H NMR method, and metabolites profiles were further analyzed by selected chemometrics algorithms to define the threshold values for product quality evaluation...
November 30, 2016: Journal of Pharmaceutical and Biomedical Analysis
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