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Salvianolic acid B

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https://www.readbyqxmd.com/read/29436996/herbal-products-for-common-auto-inflammatory-disorders-novel-approaches
#1
Fawzi Mahomoodally, Shanoo Suroowan
Common auto-inflammatory disorders (CAIDs) induce considerable suffering over the world. A panoply of synthetic medications areis available for theirits management. Nonetheless, available drug classes are limited by adverse effects, low systemic absorption, and high costs. In addition, no cure exists for most CAIDs. Interestingly, herbal products present a tremendous potential for development as anti-inflammatory agents. In this endeavor, major scientific databases; Google Scholar, Pubmed, ScienceDirect, and Scopus were explored to highlight novel therapeutic approaches using herbal products for CAIDs prophylaxis, management, treatment, and prevention of relapse...
February 12, 2018: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29434992/salvianolic-acid-b-suppresses-cell-proliferation-and-induces-apoptosis-in-osteosarcoma-through-p38-mediated-reactive-oxygen-species-generation
#2
Zhaoyang Zeng, Hua Zhang, Xin Wang, Kai Liu, Tian Li, Shaobo Sun, Hailong Li
The present study aimed to investigate the potential anticancer effect and mechanisms of salvianolic acid B on osteosarcoma. Salvianolic acid B suppressed osteosarcoma cell proliferation and induced apoptosis in the osteosarcoma MG63 cell line, and activated the expressions of cleaved caspase-3, phosphorylated-tumor protein (p)38 mitogen-activated protein kinase (p-p38 MAPK) and phosphorylated-p53 (p-p53) proteins in the MG63 cells. Additionally, Salvianolic acid B also increased the level of reactive oxygen species (ROS) generation in the MG63 cells...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433683/phytochemical-profile-of-orthosiphon-aristatus-extracts-after-storage-rosmarinic-acid-and-other-caffeic-acid-derivatives
#3
Lee Suan Chua, Cher Haan Lau, Chee Yung Chew, Nurul Izzati Mohd Ismail, Nitnipa Soontorngun
BACKGROUND: Orthosiphon aristatus (Blume) Miq. is a medicinal herb which is traditionally used for the treatment of diabetes and kidney diseases in South East Asia. Previous studies reported higher concentration of antioxidative phytochemicals, especially rosmarinic acid (ester of caffeic acid) and other caffeic acid derivatives in this plant extract than the other herbs such as rosemary and sage which are usually used as raw materials to produce rosmarinic acid supplement in the market...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29430840/screening-and-analysis-of-potential-active-components-in-shengxiong-glucose-injection-using-uhplc-coupled-with-photodiode-array-detection-and-ms-ms
#4
Meng Zhou, Rui Li, Xiang-Ming Liao, Zheng Wang, Guo-Bo Xu, Zi-Peng Gong, Yuan Lu, Xun He, Yong-Jun Li, Yong-Lin Wang, Lin Zheng, Shang-Gao Liao
Shengxiong glucose injection, a pharmaceutical preparation containing a water extract of the roots of Salvia miltiorrhizae and ligustrazine hydrochloride, is widely used in clinical to treat cardiovascular diseases in China. The chemical components of the water extract have been reported and the cardioprotective effects of the injection have been evaluated. However, the chemical constituents of the injection and their correlations with its pharmacological effects have not been established. In this study, thirteen chemical constituents of the injection have been identified or characterized by ultra high performance liquid chromatography with diode array detection and electrospray ionization quadrupole time-of-flight tandem mass spectrometry...
February 12, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29421539/salvianolic-acid-b-promotes-neural-differentiation-of-induced-pluripotent-stem-cells-via-pi3k-akt-gsk3%C3%AE-%C3%AE-catenin-pathway
#5
Tao Shu, Chang Liu, Mao Pang, Lei He, Bu Yang, Lei Fan, Shufan Zhang, Xuan Wang, Bin Liu, Limin Rong
Salvianolic acid B (Sal B), a water-soluble component mainly extracted from the traditional Chinese medicine Salvia miltiorrhiza, has potential anti-inflammatory, anti-oxidative and anti-apoptotic actions to protect neural cells. Here, we explore the effects and mechanisms of Sal B on the promotion of differentiation of induced pluripotent stem cells (iPSCs) into neural stem cells (NSCs), then further into neurons. During the processes of neural differentiation of iPSCs, Sal B or a phosphatidylinositide 3 kinase (PI3K) inhibitor (LY294002) were added to the medium...
February 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29401682/molecular-pharmacology-of-rosmarinic-and-salvianolic-acids-potential-seeds-for-alzheimer-s-and-vascular-dementia-drugs
#6
REVIEW
Solomon Habtemariam
Both caffeic acid and 3,4-dihydroxyphenyllactic acid (danshensu) are synthesized through two distinct routs of the shikimic acid biosynthesis pathway. In many plants, especially the rosemary and sage family of Lamiaceae, these two compounds are joined through an ester linkage to form rosmarinic acid (RA). A further structural diversity of RA derivatives in some plants such as Salvia miltiorrhiza Bunge is a form of RA dimer, salvianolic acid-B (SA-B), that further give rise to diverse salvianolic acid derivatives...
February 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29396922/simultaneous-determination-and-qualitative-analysis-of-six-types-of-components-in-naoxintong-capsule-by-miniaturized-matrix-solid-phase-dispersion-extraction-coupled-with-uhplc-with-photodiode-array-detection-and-q-tof-ms
#7
Huilin Wang, Yan Jiang, Mingya Ding, Jin Li, Jia Hao, Jun He, Hui Wang, Xiu-Mei Gao, Yan-Xu Chang
A simple and effective sample preparation process based on miniaturized matrix solid-phase dispersion was developed for simultaneous determination of phenolic acids (gallic acid, chlorogenic acid, ferulic acid, 3,5-dicaffeoylqunic acid, 1,5-dicaffeoylqunic acid, rosmarinic acid, lithospermic acid, salvianolic acid B), flavonoids (kaempferol-3-O-rutinoside, calycosin, formononetin), lactones (ligustilide, butyllidephthalide), monoterpenoids (paeoniflorin), phenanthraquinones (cryptotanshinone) and furans (5-hydroxymethylfurfural) in Naoxintong capsule by ultra high performance liquid chromatography...
February 3, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29384417/salvianolic-acid-a-ameliorates-renal-ischemia-reperfusion-injury-by-activating-akt-mtor-4ebp1-signaling-pathway
#8
Ying Song, Weihai Liu, Yi Ding, Yan-Yan Jia, Jinyi Zhao, Fan Wang, Juan Bai, Lianghua Cheng, Kai Gao, Meiyou Liu, Minna Yao, Liang Li, Yanmin Zhang, Aidong Wen, Langchong He
Salvianolic acid A (Sal A) has been shown to prevent and treat ischemic cardiovascular as well as cerebral vascular diseases. However, little is known about Sal A in renal ischemia/reperfusion (I/R) injury. In this study, a renal I/R injury model in rats and a hypoxia/reoxygenation (H/R) model to damage proximal renal tubular cells (HK-2) were used to assess whether Sal A halts the development and progression of renal I/R injury. As compared to vehicle treatment, Sal A significantly attenuated kidney injury and lowered plasma creatinine, blood urea nitrogen levels, the number of apoptosis-positive tubular cells, and kidney oxidative stress after renal I/R injury...
January 31, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29382534/salvianolic-acid-b-improves-airway-hyperresponsiveness-by-inhibiting-muc5ac-overproduction-associated-with-erk1-2-p38-signaling
#9
Yan Guan, Jian-Ping Zhu, Jian Shen, Yong-Liang Jia, Ya-Chao Jin, Xin-Wei Dong, Qiang-Min Xie
Salvianolic acid B (SalB) is one of the main water-soluble composites from Chinese medicine Dansen (Radix miltiorrhiza). It is used for clinical treatment of various diseases including cardiovascular, lung, Liver, renal and cancers. However, the effects of SalB to allergy induced airway mucin hypersecretion, inflammation and hyperresponsiveness (AHR) remains not clear. Overproduction of airway MUC5AC is a central effector of inflammation that is strongly associated with AHR in asthmatic attack. In this study, we investigated the anti-asthmatic activity and mechanism of SalB in a murine model and human epithelial cells by monitoring changes in mucin expression and secretion, airway inflammation, AHR, and signaling pathways...
January 27, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29349583/enhanced-production-of-phenolic-acids-in-cell-suspension-culture-of-salvia-leriifolia-benth-using-growth-regulators-and-sucrose
#10
Masoomeh Modarres, Sedigheh Esmaeilzadeh Bahabadi, Mohammad Ehsan Taghavizadeh Yazdi
Salvia leriifolia Benth. (Lamiaceae) is an endangered medicinal plant with hypoglycemic, anti-inflammatory and analgesic properties. Many of the beneficial effects of Salvia spp. are attributed to the phenolic compounds. In the present study, an efficient procedure has been developed for establishment of cell suspension culture of S. leriifolia as a strategy to obtain an in vitro phenolic acids producing cell line for the first time. The effect of growth regulators and various concentrations of sucrose have been analyzed, to optimize biomass growth and phenolic acids production...
January 18, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29288756/is-comfrey-root-more-than-toxic-pyrrolizidine-alkaloids-salvianolic-acids-among-antioxidant-polyphenols-in-comfrey-symphytum-officinale-l-roots
#11
Adriana Trifan, Sebastian E W Opitz, Roland Josuran, Andreas Grubelnik, Nils Esslinger, Samuel Peter, Sarah Bräm, Nadja Meier, Evelyn Wolfram
Comfrey root preparations are used for the external treatment of joint distortions and myalgia, due to its analgesic and anti-inflammatory properties. Up to date, key activity-determining constituents of comfrey root extracts have not been completely elucidated. Therefore, we applied different approaches to further characterize a comfrey root extract (65% ethanol). The phenolic profile of comfrey root sample was characterized by HPLC-DAD-QTOF-MS/MS. Rosmarinic acid was identified as main phenolic constituent (7...
December 27, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29258686/bioprofiling-of-salvia-miltiorrhiza-via-planar-chromatography-linked-to-bio-assays-high-resolution-mass-spectrometry-and-nuclear-magnetic-resonance-spectroscopy
#12
Ebrahim Azadniya, Gertrud E Morlock
An affordable bioanalytical workflow supports the collection of data on active ingredients, required for the understanding of health-related food, superfood and traditional medicines. Targeted effect-directed responses of single compounds in a complex sample highlight this powerful bioanalytical hyphenation of planar chromatography with (bio)assays. Among many reports about biological properties of Salvia miltiorrhiza Bunge root (Danshen) and their analytical methods, the highly efficient direct bioautography (DB) workflow has not been considered so far...
December 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29230228/overexpression-of-smmyc2-increases-the-production-of-phenolic-acids-in-salvia-miltiorrhiza
#13
Na Yang, Wenping Zhou, Jiao Su, Xiaofan Wang, Lin Li, Liru Wang, Xiaoyan Cao, Zhezhi Wang
MYC2 is a core transcription factor in the plant response to jasmonates. It also functions in secondary metabolism and various processes for growth and development. However, the knowledge about its role in Salvia miltiorrhiza is still very limited. We determined that the biosynthesis of salvianolic acid B (Sal B) was strongly induced in 2-month-old transgenic plants that over-expressed SmMYC2. In the roots of transgenic line 12 that over-expressed SmMYC2 (OEM-12), the Sal B concentration was as high as 5.95 ± 0...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29228618/calcium-homeostasis-and-endoplasmic-reticulum-stress-are-involved-in-salvianolic-acid-b-offered-protection-against-cardiac-toxicity-of-arsenic-trioxide
#14
Jing-Yi Zhang, Bin Zhang, Min Wang, Wei Wang, Ping Liao, Gui-Bo Sun, Xiao-Bo Sun
Arsenic trioxide (ATO) is a potent anticancer agent used to treat acute promyelocytic leukemia. However, its cardiotoxicity limits ATO's widespread clinical use. Previous studies demonstrated that ATO may aggravate Ca2+ overload and promote endoplasmic reticulum stress (ERS). Salvianolic acid B (Sal B) is cardioprotective against ATO and enhances ATO's anticancer activities. The present study assessed whether the Sal B protective effect was related to maintenance of Ca2+ homeostasis and inhibition of ER stress...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29224910/regulation-of-sirt3-foxo1-signaling-pathway-in-rats-with-non-alcoholic-steatohepatitis-by-salvianolic-acid-b
#15
Yingchun Wang, Juan Chen, Weizong Kong, Ruiping Zhu, Kai Liang, Quanxiang Kan, Yanhong Lou, Xiangyu Liu
AIMS: To explore the effect of salvianolic acid B (Sal B) on regulation of SIRT3/FOXO1 signaling pathway in rats with non-alcoholic steatohepatitis (NASH). METHODS: Sixty Sprague Dawley (SD) rats were randomly divided into control, model and treatment groups. After 12 weeks of successful model establishment with high fat diet, treatment group was given Sal B by intragastric administration. After 12 weeks of treatment, rats were sacrificed and livers were taken to test indicators such as liver index, TG, TC, ALT, AST, reactive oxygen species (ROS) by DCFH-DA probe, SOD2 activity by WST-8 test...
December 7, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29212498/salvianolic-acid-b-protects-against-lipopolysaccharide-induced-behavioral-deficits-and-neuroinflammatory-response-involvement-of-autophagy-and-nlrp3-inflammasome
#16
Pei Jiang, Yujin Guo, Ruili Dang, Mengqi Yang, Dehua Liao, Huande Li, Zhen Sun, Qingyan Feng, Pengfei Xu
BACKGROUND: The NLRP3 inflammasome activation and neuroinflammation are known to be involved in the pathology of depression, whereas autophagy has multiple effects on immunity, which is partly mediated by the regulation of inflammasome and clearance of proinflammatory cytokines. Given the emerging evidence that autophagy dysfunction plays an essential role in depression, it is very likely that autophagy may interact with the inflammatory process in the development and treatment of depression...
December 6, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29207039/effective-component-of-salvia%C3%A2-miltiorrhiza-in-promoting-cardiomyogenic-differentiation-of-human-placenta%C3%A2-derived-mesenchymal-stem-cells
#17
Kun Li, Jieqiong Song, Qian Zhao, Bo Wang, Yunli Zhang, Xuezhe Wang, Tiantian Tang, Shizheng Li
Our previous study indicated that Salvia miltiorrhiza (SM) induced human placenta‑derived mesenchymal stem cells (hPDMSCs) to differentiate into cardiomyocytes, however, the effective component of SM in promoting cardiomyogenic differentiation remained to be elucidated. In the present study, the most commonly examined components of SM, including danshensu, salvianolic acid B, protocatechuic aldehyde, tanshinone I (TS I), TS IIA and cryptotanshinone, were used to determine the effective components of SM in promoting cardiomyogenic differentiation...
November 28, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29180227/mechanism-of-salvianolic-acid-b-neuroprotection-against-ischemia-reperfusion-induced-cerebral-injury
#18
Yong Fan, Qianping Luo, Jingjing Wei, Ruhui Lin, Lili Lin, Yongkun Li, Zhaorong Chen, Wei Lin, Qi Chen
The purpose of this study was to evaluate the cerebral protection of salvianolic acid B (Sal B) against cerebral I/R injury and investigate the underlying mechanism. As shown by 2,3,5-Triphenyltetrazolium chloride (TTC) staining and magnetic resonance imaging (MRI) analyses, Sal B significantly reduced cerebral infarct size, and accompanied with improved neurobehavioral functions as indicated by the modified Bederson score and Longa five-point scale. Sal B decreased the production of reactive oxygen species (p<0...
November 24, 2017: Brain Research
https://www.readbyqxmd.com/read/29170782/coordination-driven-assembly-of-catechol-modified-chitosan-for-the-kidney-specific-delivery-of-salvianolic-acid-b-to-treat-renal-fibrosis
#19
Jing Li, Cuiting Zhang, Weiming He, Hongzhi Qiao, Jiahui Chen, KaiKai Wang, David Oupický, Minjie Sun
Kidney-specific delivery is critically important for the treatment of renal fibrosis with drugs such as salvianolic acid B (Sal B). Here we report a kidney-specific nanocomplex formed by the coordination-driven assembly of catechol-modified low molecular weight chitosan (HCA-Chi), calcium ions and Sal B. The prepared HCA-Chi-Ca-Sal B (HChi-Ca-Sal B) nanocomplex reversed the TGF-β1-induced epithelial-mesenchymal transition (EMT) in HK-2 cells. In vivo imaging demonstrated a kidney-specific biodistribution of the nanocomplex...
November 24, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29147659/retracted-study-of-effect-of-salvianolic-acid-b-on-motor-function-recovery-in-rats-with-spinal-cord-injury
#20
BioMed Research International
[This retracts the article DOI: 10.1155/2014/931850.].
2017: BioMed Research International
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