keyword
https://read.qxmd.com/read/34841222/pannexin-1-channel-opening-is-critical-for-covid-19-pathogenesis
#21
JOURNAL ARTICLE
Ross Luu, Silvana Valdebenito, Eliana Scemes, Antonio Cibelli, David Spray, Maximiliano Rovegno, Juan Tichauer, Andrea Cottignies-Calamarte, Arielle Rosenberg, Calude Capron, Sandrine Belouzard, Jean Dubuisson, Djallali Annane, Geoffroy Lorin de la Grandmaison, Elisabeth Cramer-Bordé, Morgane Bomsel, Eliseo Eugenin
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly rampaged worldwide, causing a pandemic of coronavirus disease (COVID -19), but the biology of SARS-CoV-2 is under investigation. We demonstrate that both SARS-CoV-2 spike protein and human coronavirus 229E (hCoV-229E) or its purified S protein, one of the main viruses responsible for the common cold, induce the transient opening of Pannexin-1 (Panx-1) channels in human lung epithelial cells. However, the Panx-1 channel opening induced by SARS-CoV-2 is greater and more prolonged than hCoV-229E/S protein, resulting in ATP, PGE2 , and IL-1β release...
November 19, 2021: IScience
https://read.qxmd.com/read/34679696/dieckol-reduces-muscle-atrophy-by-modulating-angiotensin-type-ii-type-1-receptor-and-nadph-oxidase-in-spontaneously-hypertensive-rats
#22
JOURNAL ARTICLE
Seyeon Oh, Jin Young Yang, Chul Hyun Park, Kuk Hui Son, Kyunghee Byun
The renin-angiotensin system is involved in the development of hypertension and sarcopenia. Increased levels of angiotensin II (Ang II) lead to upregulation of Ang II type 1 receptor (AT1R), which results in increasing reactive oxygen species (ROS) by NAD(P)H oxidase (Nox). Increased ROS led to increased helper T17 (Th17) and decreased regulatory T (Treg) cells through HIF-1α. Increased Th17 secretes more IL-17, leading to increased NF-κB and muscle atrophy. We evaluated the effect of Ecklonia cava extracts (ECE) and dieckol (DK) on attenuating muscle atrophy by decreasing AT1R and NOX activity in spontaneous hypertensive rats (SHRs)...
September 30, 2021: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/34660622/idiopathic-bilateral-extraocular-myositis-in-a-subject-with-poorly-controlled-type-2-diabetes-mellitus-case-report
#23
Fuminori Tatsumi, Yoshiro Fushimi, Junpei Sanada, Masashi Shimoda, Kenji Kohara, Tomohiko Kimura, Atsushi Obata, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
Background: Extraocular myositis is characterized by acute onset of orbital pain, extraocular muscle swelling, absence of thyroid disease, and effectiveness of steroid therapy. While oculomotor nerve paralysis is often observed in subjects with diabetes mellitus, extraocular muscle paralysis is very rare among various diabetic mononeuropathies. In addition, while most diabetic mononeuropathies are observed as sporadic and/or unilateral neuropathy, bilateral mononeuropathy is also very rare. Case presentation: A 58-year-old male visited our institution due to diplopia...
2021: Frontiers in Medicine
https://read.qxmd.com/read/34589395/clinical-efficacies-underlying-mechanisms-and-molecular-targets-of-chinese-medicines-for-diabetic-nephropathy-treatment-and-management
#24
REVIEW
Guoyi Tang, Sha Li, Cheng Zhang, Haiyong Chen, Ning Wang, Yibin Feng
Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional strategies, such as renin-angiotensin-aldosterone system blockade, blood glucose level control, and bodyweight reduction, may not achieve satisfactory outcomes in many clinical practices for DN management. Notably, due to the multi-target function, Chinese medicine possesses promising clinical benefits as primary or alternative therapies for DN treatment...
September 2021: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/34173766/urgent-percutaneous-coronary-artery-intervention-and-coronary-artery-bypass-grafting-in-stemi-patients-with-confirmed-covid-19
#25
JOURNAL ARTICLE
Gökhan Keskin, Ayhan Uysal, Esra Erturk, Erhan Hafız, Omer Faruk Dogan
BACKGROUND: Our aim of this study was to evaluate the cardiac symptoms, coronary angiographic results, and clinical outcomes of patients with confirmed COVID-19 and ST-segment elevation with myocardial infarction (STEMI) or myocardial ischemia. MATERIAL AND METHODS: Thirty-seven patients, who already were confirmed with COVID-19 using reverse transcriptase-polymerase chain reaction (RT-PCR), were admitted to our hospital due to chest pain with STEMI. The median patient age was 66 years (range: 27-84 years)...
June 23, 2021: Heart Surgery Forum
https://read.qxmd.com/read/34089819/bioactivity-bioavailability-and-gut-microbiota-transformations-of-dietary-phenolic-compounds-implications-for-covid-19
#26
REVIEW
Paula R Augusti, Greicy M M Conterato, Cristiane C Denardin, Inês D Prazeres, Ana Teresa Serra, Maria R Bronze, Tatiana Emanuelli
The outbreak of mysterious pneumonia at the end of 2019 is associated with widespread research interest worldwide. The coronavirus disease-19 (COVID-19) targets multiple organs through inflammatory, immune, and redox mechanisms, and no effective drug for its prophylaxis or treatment has been identified until now. The use of dietary bioactive compounds, such as phenolic compounds (PC), has emerged as a putative nutritional or therapeutic adjunct approach for COVID-19. In the present study, scientific data on the mechanisms underlying the bioactivity of PC and their usefulness in COVID-19 mitigation are reviewed...
November 2021: Journal of Nutritional Biochemistry
https://read.qxmd.com/read/33812737/effects-of-carotid-baroreceptor-stimulation-on-aortic-remodeling-in-obese-rats
#27
JOURNAL ARTICLE
Qiao Yu, Ling Shu, Lang Wang, Kaile Gao, Jing Wang, Mingyan Dai, Quan Cao, Yijie Zhang, Qiang Luo, Bangwang Hu, Dilin Dai, Jie Chen, Mingwei Bao
BACKGROUND AND AIM: Our previous study found carotid baroreceptor stimulation (CBS) reduces body weight and white adipose tissue (WAT) weight, restores abnormal secretion of adipocytokines and inflammation factors, decreases systolic blood pressure (SBP) by inhibiting activation of sympathetic nervous system (SNS) and renin-angiotensin system (RAS) in obese rats. In this study, we explore effects of CBS on aortic remodeling in obese rats. METHODS AND RESULTS: Rats were fed high-fat diet (HFD) for 16 weeks to induce obesity and underwent either CBS device implantation and stimulation or sham operation at 8 weeks...
February 9, 2021: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://read.qxmd.com/read/33631165/protective-effect-of-sirt6-on-cholesterol-crystal-induced-endothelial-dysfunction-via-regulating-ace2-expression
#28
JOURNAL ARTICLE
Zihan Zheng, Wang Bo, Xiaohan Lv, Feng Yao, Hongqian Gao, Zhen Jin, Yizhen Liu, Ying Deng, Danli Chen, Xuan Ning, Weirong Wang, Jianyu He, Rong Lin
Sirtuins are a family of highly conserved nicotinamide adenine dinucleotide (NAD+ )-dependent enzymes. Among the sirtuins, SIRT1 and SIRT6 participate in the regulation of endothelial functions and play significant roles in the physiological and pathological processes of cardiovascular diseases (CVD). Recently, our study found that minute cholesterol crystals (CC) can be endocytosed by endothelial cells and further impair endothelial functions. Since previous studies have reported that angiotensin-converting enzyme (ACE2) involves Angiotensin (Ang) II-induced inflammation in endothelial cells, this study was designed to investigate the role of SIRT1 and SIRT6 in CC-induced variation of ACE2 expression and the related mechanism between SIRT6 and ACE2...
February 22, 2021: Experimental Cell Research
https://read.qxmd.com/read/33198253/novel-therapeutic-effects-of-pterosin-b-on-ang-ii-induced-cardiomyocyte-hypertrophy
#29
JOURNAL ARTICLE
Chang Youn Lee, Han Ki Park, Bok-Sim Lee, Seongtae Jeong, Sung-Ae Hyun, Jung-Won Choi, Sang Woo Kim, Seahyoung Lee, Soyeon Lim, Ki-Chul Hwang
Pathological cardiac hypertrophy is characterized by an abnormal increase in cardiac muscle mass in the left ventricle, resulting in cardiac dysfunction. Although various therapeutic approaches are being continuously developed for heart failure, several studies have suggested natural compounds as novel potential strategies. Considering relevant compounds, we investigated a new role for Pterosin B for which the potential life-affecting biological and therapeutic effects on cardiomyocyte hypertrophy are not fully known...
November 12, 2020: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/32938216/activation-of-m3achr-type-3-muscarinic-acetylcholine-receptor-and-nrf2-nuclear-factor-erythroid-2-related-factor-2-signaling-by-choline-alleviates-vascular-smooth-muscle-cell-phenotypic-switching-and-vascular-remodeling
#30
JOURNAL ARTICLE
Xi He, Juan Deng, Xiao-Jiang Yu, Si Yang, Yang Yang, Wei-Jin Zang
OBJECTIVE: Phenotypic switching of vascular smooth muscle cells (VSMCs) plays a critical role in atherosclerosis, vascular restenosis, and hypertension. Choline exerts cardioprotective effects; however, little is known about its effects on VSMC phenotypic switching and vascular remodeling. Here, we investigated whether choline modulates VSMC phenotypic changes and explored the underlying mechanisms. Approach and Results: In cultured VSMCs, choline promoted Nrf2 (nuclear factor erythroid 2-related factor 2) nuclear translocation, inducing the expression of HO-1 (heme oxygenase-1) and NQO-1 (NAD[P]H quinone oxidoreductase-1)...
September 17, 2020: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/32923459/adamts-5-decreases-in-aortas-and-plasma-from-aortic-dissection-patients-and-alleviates-angiotensin-ii-induced-smooth-muscle-cell-apoptosis
#31
JOURNAL ARTICLE
Tao Zeng, Jianting Gan, Yu Liu, Lei Shi, Zhengde Lu, Yan Xue, Rixin Xiong, Ling Liu, Zicong Yang, Yingzhong Lin, Jun Yuan
Background: Acute aortic dissection (AAD) is associated with degeneration of the aortic media and accompanied by vascular extracellular matrix (ECM) remodeling. Recently, a disintegrin and metalloproteinase with thrombospondin type 1 motifs-5 (ADAMTS-5) has been reported to be involved in ECM remodeling and vascular diseases. The aim of this study was to examine ADAMTS-5 levels in AAD patients and investigate the underlying mechanisms. Methods: Aortic tissue samples were collected from normal donors and AAD patients, and the expression of ADAMTS-5 was analyzed in all aortic tissues...
2020: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/31710686/niacin-protects-against-abdominal-aortic-aneurysm-formation-via-gpr109a-independent-mechanisms-role-of-nad-nicotinamide
#32
JOURNAL ARTICLE
Tetsuo Horimatsu, Andra L Blomkalns, Mourad Ogbi, Mary Moses, David Kim, Sagar Patel, Nicole Gilreath, Lauren Reid, Tyler W Benson, Jonathan Pye, Samah Ahmadieh, Allie Thompson, Nathan Robbins, Adrien Mann, Ashlee Edgell, Stephanie Benjamin, Brian K Stansfield, Yuqing Huo, David J Fulton, Gautam Agarwal, Nagendra Singh, Stefan Offermanns, Neal L Weintraub, Ha Won Kim
AIMS: Chronic adventitial and medial infiltration of immune cells play an important role in the pathogenesis of abdominal aortic aneurysms (AAAs). Nicotinic acid (niacin) was shown to inhibit atherosclerosis by activating the anti-inflammatory G protein-coupled receptor GPR109A [also known as hydroxycarboxylic acid receptor 2 (HCA2)] expressed on immune cells, blunting immune activation and adventitial inflammatory cell infiltration. Here, we investigated the role of niacin and GPR109A in regulating AAA formation...
December 1, 2020: Cardiovascular Research
https://read.qxmd.com/read/31340681/sirtuin-3-deficiency-accelerates-angiotensin-ii-induced-skeletal-muscle-atrophy
#33
JOURNAL ARTICLE
Jianheng Zheng, Jing Gao, Qiuping Zhang, Xiahong Wu, Weili Shen, Mengwei Sun
Background : It has been reported that Angiotensin II (Ang II) induced skeletal muscle atrophy. However, the precise mechanisms remain elusive. Sirtuin 3 (SIRT3), an NAD-dependent deacetylase, plays a central role in maintaining cellular metabolic homeostasis. This work aims to determine the role of SIRT3-mediated cellular metabolism in skeletal muscle wasting. Methods and Results : Eight-week-old male wild-type (WT) and SIRT3 knockout (SIRT3 KO) mice were infused with Ang II or saline for 4 weeks. Ang II induces skeletal muscle atrophy by inducing expression of the muscle-enriched E3 ubiquitin ligase muscle RING-finger-1 (MuRF1) and atrogin-1, accompanied by a reduction in SIRT3 in skeletal muscle...
November 2020: Connective Tissue Research
https://read.qxmd.com/read/31179321/quantitative-proteomic-analysis-reveals-the-deregulation-of-nicotinamide-adenine-dinucleotide-metabolism-and-cd38-in-inflammatory-bowel-disease
#34
COMPARATIVE STUDY
LongGui Ning, Guodong Shan, Zeyu Sun, Fenming Zhang, Chengfu Xu, Xinhe Lou, Sha Li, Haojie Du, Hongtan Chen, Guoqiang Xu
Inflammatory bowel disease (IBD) has become a major health challenge worldwide. However, the precise etiological and pathophysiological factors involved in IBD remain unclear. Proteomics can be used for large-scale protein identification analysis. In the current study, using tandem mass tag- (TMT-) based shotgun proteomics, proteomic differences between intestinal tissue from health controls, patients with Crohn's disease (CD), and patients with ulcerative colitis (UC) were compared. Proteins with fold change >2 or <0...
2019: BioMed Research International
https://read.qxmd.com/read/30691489/in-utero-exposure-to-ultrafine-particles-promotes-placental-stress-induced-programming-of-renin-angiotensin-system-related-elements-in-the-offspring-results-in-altered-blood-pressure-in-adult-mice
#35
JOURNAL ARTICLE
Russell A Morales-Rubio, Isabel Alvarado-Cruz, Natalia Manzano-León, Maria-de-Los-Angeles Andrade-Oliva, Marisela Uribe-Ramirez, Betzabet Quintanilla-Vega, Álvaro Osornio-Vargas, Andrea De Vizcaya-Ruiz
BACKGROUND: Exposure to particulate matter (PM) is associated with an adverse intrauterine environment, which can promote adult cardiovascular disease (CVD) risk. Ultrafine particles (UFP) (small size and large surface area/mass ratio) are systemically distributed, induce inflammation and oxidative stress, and have been associated with vascular endothelial dysfunction and arterial vasoconstriction, increasing hypertension risk. Placental stress and alterations in methylation of promoter regions of renin-angiotensin system (RAS)-related elements could be involved in UFP exposure-related programming of hypertension...
January 28, 2019: Particle and Fibre Toxicology
https://read.qxmd.com/read/30516514/medical-basis-of-diabetic-neuropathy-formation-review
#36
REVIEW
A Archvadze, A Kistauri, N Gongadze, T Makharadze, K Chirakadze
Nowadays, chronic diseases are leading cause of death worldwide. One of popular chronic disease of 21 century is Diabetes Mellitus (DM) that affected 422 million people around the world in 2014; its prevalence is expected to increase to 592 million by the year 2035. Diabetic neuropathy (DN) seems to be the most common and least understood complication being present in over 50% of chronic diabetics. As the latest date explain the pathogenesis of DN is not fully understood. Therefore, considering the widespread of DN, severity of its consequences, it is vital to investigate details of its pathophysiology and find therapeutic strategies to improve patients' condition...
October 2018: Georgian Medical News
https://read.qxmd.com/read/30485352/conservatively-managed-patients-with-non-st-segment-elevation-acute-coronary-syndrome-are-undertreated-with-indicated-medicines
#37
JOURNAL ARTICLE
Elena Candela, Francisco Marín, José Miguel Rivera-Caravaca, Nuria Vicente Ibarra, Luna Carrillo, María Asunción Esteve-Pastor, Teresa Lozano, Manuel Jesús Macías, Vicente Pernias, Miriam Sandín, Esteban Orenes-Piñero, Miriam Quintana-Giner, Ignacio Hortelano, Beatriz Villamía, Andrea Veliz, Mariano Valdés, Juan G Martínez-Martínez, Juan M Ruiz-Nodar
INTRODUCTION AND AIMS: Patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) are often managed conservatively. Clinical practice guidelines recommend treating these patients with the same pharmacological drugs as those who receive invasive treatment. We analyze the use of new antiplatelet drugs (NADs) and other recommended treatments in people discharged following an NSTE-ACS according to the treatment strategy used, comparing the medium-term prognosis between groups. METHODS: Prospective observational multicenter registry study in 1717 patients discharged from hospital following an ACS; 1143 patients had experienced an NSTE-ACS...
2018: PloS One
https://read.qxmd.com/read/30426047/data-on-the-effect-of-angiotensin-ii-and-6-hydroxydopamine-on-reactive-oxygen-species-production-antioxidant-gene-expression-and-viability-of-different-neuronal-cell-lines
#38
JOURNAL ARTICLE
Juan A Parga, Ana I Rodriguez-Perez, Maria Garcia-Garrote, Jannette Rodriguez-Pallares, Jose L Labandeira-Garcia
This article describes the effect of the oxidative stress inducers Angiotensin II and 6-hydroxydopamine (6-OHDA) on different cell lines. The levels of expression Angiotensin type 1 and type 2 receptors in different dopaminergic cell lines are shown. The data indicate that treatment with Angiotensin II and 6-OHDA increases the production of reactive oxygen species (ROS) and decreases cell viability. NRF2 is a transcription factor induced by ROS. We provide data that NRF2 overexpression increases cell viability in response to oxidative stress inducers compared to control cells, and that these inducers can, both separately and in combination, enhance the expression of NRF2-regulated genes heme oxygenase 1 (Hmox1), NAD(P)H quinone dehydrogenase 1 (Nqo1) and Kruppel like factor 9 (Klf9)...
December 2018: Data in Brief
https://read.qxmd.com/read/30359575/parp-1-inhibition-protects-the-diabetic-heart-through-activation-of-sirt1-pgc-1%C3%AE-axis
#39
JOURNAL ARTICLE
Maayan Waldman, Vadim Nudelman, Asher Shainberg, Nader G Abraham, Ran Kornwoski, Dan Aravot, Michael Arad, Edith Hochhauser
Type 2 diabetes mellitus (DM2) follows impaired glucose tolerance in obesity and is frequently associated with hypertension, causing adverse myocardial remodelling and leading to heart failure. The DNA bound protein PARP (poly ADP ribose) polymerase catalyses a post translational modification (polymerization of negatively charged ADP-ribose chains) of nuclear proteins. PARP-1 activation is NAD+ dependent and takes part in DNA repair and in chromatin remodelling and has a function in transcriptional regulation, intracellular trafficking and energy metabolism...
December 15, 2018: Experimental Cell Research
https://read.qxmd.com/read/30315936/angiotensin-ii-induces-oxidative-stress-and-upregulates-neuroprotective-signaling-from-the-nrf2-and-klf9-pathway-in-dopaminergic-cells
#40
JOURNAL ARTICLE
Juan A Parga, Ana I Rodriguez-Perez, Maria Garcia-Garrote, Jannette Rodriguez-Pallares, Jose L Labandeira-Garcia
Nuclear factor-E2-related factor 2 (NRF2) is a transcription factor that activates the antioxidant cellular defense in response to oxidative stress, leading to neuroprotective effects in Parkinson's disease (PD) models. We have previously shown that Angiotensin II (AngII) induces an increase in reactive oxygen species (ROS) via AngII receptor type 1 and NADPH oxidase (NOX), which may activate the NRF2 pathway. However, controversial data suggest that AngII induces a decrease in NRF2 signaling leading to an increase in oxidative stress...
October 11, 2018: Free Radical Biology & Medicine
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