Dinh Viet Hoang, Le Thi Thanh Thuy, Hoang Hai, Vu Ngoc Hieu, Kenjiro Kimura, Daisuke Oikawa, Yoshihiro Ikura, Ninh Quoc Dat, Truong Huu Hoang, Misako Sato-Matsubara, Minh Phuong Dong, Ngo Vinh Hanh, Sawako Uchida-Kobayashi, Fuminori Tokunaga, Shoji Kubo, Naoko Ohtani, Katsutoshi Yoshizato, Norifumi Kawada
Pancreatic cancer is a highly challenging malignancy with extremely poor prognosis. Cytoglobin (CYGB), a hemeprotein involved in liver fibrosis and cancer development, is expressed in pericytes of all organs. Here, we examined the role of CYGB in the development of pancreatic cancer. CYGB expression appeared predominately in the area surrounding adenocarcinoma and negatively correlated with tumor size in patients with pancreatic cancer. Directly injecting 7, 12-dimethylbenz[a]anthracene into the pancreatic tail in wild-type mice resulted in time-dependent induction of severe pancreatitis, fibrosis, and oxidative damage, which was rescued by Cygb overexpression in transgenic mice...
May 3, 2022: Oncogenesis