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Cognitive Frailty

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https://www.readbyqxmd.com/read/27908316/-frail-patients-and-surgery
#1
Nadia A Henriksen, Frederik Helgstrand, Ismail Gögenur
It is estimated that 15% of patients above 65 years of age are frail. Frail patients have significantly higher risk of post-operative complications when undergoing both elective and emergency surgery than patients who are not frail. Therefore, it is recommended that all patients above 65 years are frailty scored prior to a surgical procedure. It seems advisable to include the following items in a multimodal frailty score: evaluation of the patient's cognitive ability, functional status, nutritional status and pulmonary and cardiac function...
November 21, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/27903307/the-cumulative-effect-of-frailty-and-cognition-on-mortality-results-of-a-prospective-cohort-study
#2
Philip D St John, Suzanne L Tyas, Lauren E Griffith, Verena Menec
BACKGROUND: Both physical frailty and cognitive impairment predict death, but the joint effect of these two factors is uncertain. The objectives are to determine if the Mini-mental state examination (MMSE) and the Frailty Index (FI) predict death over a five-year interval after accounting for the effect of the other; and if there is an interaction in this effect. METHODS: An analysis of an existing prospective cohort study of 1,751 community living older adults followed over a five-year time frame...
December 1, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27899117/assistive-products-and-the-sustainable-development-goals-sdgs
#3
Emma Tebbutt, Rebecca Brodmann, Johan Borg, Malcolm MacLachlan, Chapal Khasnabis, Robert Horvath
The Sustainable Development Goals (SDGs) have placed great emphasis on the need for much greater social inclusion, and on making deliberate efforts to reach marginalized groups. People with disabilities are often marginalized through their lack of access to a range of services and opportunities. Assistive products can help people overcome impairments and barriers enabling them to be active, participating and productive members of society. Assistive products are vital for people with disabilities, frailty and chronic illnesses; and for those with mental health problems, and gradual cognitive and physical decline characteristic of aging populations...
November 29, 2016: Globalization and Health
https://www.readbyqxmd.com/read/27896796/development-and-validation-of-a-frailty-index-in-the-longitudinal-aging-study-amsterdam
#4
Emiel O Hoogendijk, Olga Theou, Kenneth Rockwood, Bregje D Onwuteaka-Philipsen, Dorly J H Deeg, Martijn Huisman
BACKGROUND: Frailty is a state of increased vulnerability to adverse outcomes. The frailty index (FI), defined by the deficit accumulation approach, is a sensitive instrument to measure levels of frailty, and therefore important for longitudinal studies of aging. AIMS: To develop an FI in the Longitudinal Aging Study Amsterdam (LASA), and to examine the predictive validity of this FI for 19-year mortality. METHODS: LASA is an ongoing study among Dutch older adults, based on a nationally representative sample...
November 28, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27895474/efficacy-of-l-carnitine-supplementation-on-frailty-status-and-its-biomarkers-nutritional-status-and-physical-and-cognitive-function-among-prefrail-older-adults-a-double-blind-randomized-placebo-controlled-clinical-trial
#5
M Badrasawi, Suzana Shahar, A M Zahara, R Nor Fadilah, Devinder Kaur Ajit Singh
BACKGROUND: Frailty is a biological syndrome of decreased reserve and resistance to stressors due to decline in multiple physiological systems. Amino acid deficiency, including L-carnitine, has been proposed to be associated with its pathophysiology. Nevertheless, the efficacy of L-carnitine supplementation on frailty status has not been documented. Thus, this study aimed to determine the effect of 10-week L-carnitine supplement (1.5 g/day) on frailty status and its biomarkers and also physical function, cognition, and nutritional status among prefrail older adults in Klang Valley, Malaysia...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27888278/missing-domains-of-lung-transplant-patient-selection
#6
Nancy P Blumenthal, Michael G Petty, Ruth McCorkle
: The goal of consistent, predictable, and improved outcomes has continued to elude the scientific community in the 30 years since lung transplantation became the procedure of choice for patients with terminal, nonmalignant lung disease. BACKGROUND: Although there is consensus regarding disease-specific indications for lung transplant, ambiguity remains regarding how patient-specific attributes should influence lung transplant candidacy. This study had 3 aims (1) to establish the missing domains of the interdisciplinary assessment of the lung transplant candidate, (2) to have these domains validated by an international panel of lung transplant experts, and (3) to recommend the next step for inclusion of these domains into the lung transplant candidate selection process...
November 25, 2016: Progress in Transplantation
https://www.readbyqxmd.com/read/27884130/a-profile-of-the-clinical-course-of-cognition-and-comorbidity-in-mild-cognitive-impairment-and-dementia-study-the-4c-study-two-complementary-longitudinal-clinical-cohorts-in-the-netherlands
#7
Weiqi Liao, Renske E G Hamel, Marcel G M Olde Rikkert, Saskia M Oosterveld, Pauline Aalten, Frans R J Verhey, Philip Scheltens, Nicole Sistermans, Yolande A L Pijnenburg, Wiesje M van der Flier, Inez H G B Ramakers, René J F Melis
BACKGROUND: Heterogeneous disease trajectories of mild cognitive impairment (MCI) and dementia are frequently encountered in clinical practice, but there is still insufficient knowledge to understand the reasons and mechanisms causing this heterogeneity. In addition to correlates of the disorder, patient characteristics such as their health status, social environment, comorbidities and frailty may contribute to variability in trajectories over time. The current paper outlines the study design and the study population of and provides an overview of the data collected in the Clinical Course of Cognition and Comorbidity in Mild Cognitive Impairment (4C-MCI cohort, n = 315) and Dementia (4C-Dementia cohort, n = 331) Study...
November 25, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27883167/frailty-is-a-geriatric-syndrome-characterized-by-multiple-impairments-a-comprehensive-approach-is-needed
#8
L-K Chen, A-C Hwang, L-K Liu, W-J Lee, L-N Peng
OBJECTIVE: To evaluate the prevalence of frailty and the associated multimorbidity and functional impairments among community-dwelling middle-aged and elderly people in Taiwan. DESIGN: a cross-sectional study. SETTING: communities in I-Lan County of Taiwan. PARTICIPANTS: 1839 community-dwelling people aged 50 years and older. INTERVENTION: None. MEASUREMENTS: Frailty defined by Fried's criteria, Charlson's comorbidity index (CCI), Functional Autonomy Measurement System (SMAF), Center for Epidemiologic Studies Depression Scale (CES-D), Mini-Nutrition Assessment (MNA), Mini-Mental State Examination (MMSE), and Short Form-12 quality of life questionnaire...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27874275/executive-functioning-in-men-and-women-with-an-autism-spectrum-disorder
#9
Michelle Kiep, Annelies A Spek
Executive functioning (EF) is thought to be linked to autism spectrum disorders (ASD) specific symptoms. The majority of research has focused on children and adolescents with ASD and, therefore, little is known about EF in adults. Furthermore, little is known about gender differences. Ninety-nine men and forty women with ASD were compared with and 35 neurotypical men 25 neurotypical women. Participants were matched on age, total intelligence, and verbal ability. The following instruments were used to measure executive functioning: digit span and letter and number sequencing of the WAIS-III, Tower of Hanoi, WCST, and Verbal fluency...
November 22, 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27871235/development-of-the-interrai-home-care-frailty-scale
#10
John N Morris, Elizabeth P Howard, Knight R Steel
BACKGROUND: The concept of frailty, a relative state of weakness reflecting multiple functional and health domains, continues to receive attention within the geriatrics field. It offers a summary of key personal characteristics, providing perspective on an individual's life course. There have been multiple attempts to measure frailty, some focusing on physiologic losses, others on specific diseases, disabilities or health deficits. Recently, multidimensional approaches to measuring frailty have included cognition, mood and social components...
November 21, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27869890/-anmco-sic-sici-gise-sicch-consensus-document-risk-stratification-in-elderly-patients-undergoing-cardiac-surgery-and-transcatheter-aortic-valve-implantation
#11
Giovanni Pulignano, Michele Massimo Gulizia, Samuele Baldasseroni, Francesco Bedogni, Giovanni Cioffi, Ciro Indolfi, Francesco Romeo, Adriano Murrone, Francesco Musumeci, Alessandro Parolari, Leonardo Patanè, Paolo Giuseppe Pino, Annalisa Mongiardo, Carmen Spaccarotella, Roberto Di Bartolomeo, Giuseppe Musumeci
Aortic stenosis is one the most frequent valvular diseases in developed countries, and its impact on public healthcare resources and assistance is increasing. A substantial proportion of elderly patients with severe aortic stenosis is frequently not eligible for surgery because of advanced age, frailty and multiple comorbidities. Transcatheter aortic valve implantation (TAVI) enables the treatment of very elderly patients at high or prohibitive surgical risk considered ineligible for surgery and with an acceptable life expectancy...
September 2016: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/27869882/-assessment-of-geriatric-patients-care-needs-based-on-sosia-classification-the-reality-of-the-lombardy-region-in-nursing-home
#12
Mariangela Vanalli
The increased demand to care that originates from demographic changes called in Italy a rapid development in Nursing Home with particular emergency the problem of programme the welfare response. It is essential the development of a classification system able to describe the stratification of the case mix on the basis of the care requirements, allowing a remuneration in function of the complexity care. Since 2003, the Lombardy region has introduced a case-mix reimbursement system for nursing homes based on the SOSIA form which classifies residents into eight classes of frailty...
November 2016: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/27869500/lower-frailty-is-associated-with-successful-cognitive-aging-among-older-adults-with-hiv
#13
Lindsay Mk Wallace, Maria Ferrara, Thomas D Brothers, Sara Garlassi, Susan A Kirkland, Olga Theou, Stefano Zona, Cristina Mussini, David J Moore, Kenneth Rockwood, Giovanni Guaraldi
BACKGROUND: Aging with HIV poses unique and complex challenges, including avoidance of neurocognitive disorder. Our objective here is to identify the prevalence and predictors of successful cognitive aging (SCA) in sample of older adults with HIV. METHODS: One hundred three HIV-infected individuals aged 50 and older were recruited from the Modena HIV Metabolic Clinic in Italy. Participants were treated with combination antiretroviral therapy (cART) for at least one year and had suppressed plasma HIV viral load...
November 21, 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27861714/factors-influencing-transitions-between-frailty-states-in-elderly-adults-the-progetto-veneto-anziani-longitudinal-study
#14
Caterina Trevisan, Nicola Veronese, Stefania Maggi, Giovannella Baggio, Elena Debora Toffanello, Sabina Zambon, Leonardo Sartori, Estella Musacchio, Egle Perissinotto, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi
OBJECTIVES: To investigate frailty state transitions in a cohort of older Italian adults to identify factors exacerbating or improving frailty conditions. DESIGN: Population-based longitudinal study with mean follow-up of 4.4 years. SETTING: Community. PARTICIPANTS: Individuals enrolled in the Progetto Veneto Anziani (Pro.V.A.) (N = 2,925; n = 1,179 male, n = 1,746 female; mean age 74.4 ± 7.3). MEASUREMENTS: Frailty was identified at baseline and follow-up based on the presence of at least three Fried criteria; prefrailty was defined as the presence of one or two Fried criteria...
November 14, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27852810/multicomponent-cardiac-rehabilitation-in-patients-after-transcatheter-aortic-valve-implantation-predictors-of-functional-and-psychocognitive-recovery
#15
Sarah Eichler, Annett Salzwedel, Rona Reibis, Jörg Nothroff, Axel Harnath, Martin Schikora, Christian Butter, Karl Wegscheider, Heinz Völler
BACKGROUND: In the last decade, transcatheter aortic valve implantation has become a promising treatment modality for patients with aortic stenosis and a high surgical risk. Little is known about influencing factors of function and quality of life during multicomponent cardiac rehabilitation. METHODS: From October 2013 to July 2015, patients with elective transcatheter aortic valve implantation and a subsequent inpatient cardiac rehabilitation were enrolled in the prospective cohort multicentre study...
November 16, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27852640/janus-at-the-crossroads-perspectives-on-long-term-care-trajectories-for-older-women-with-dementia-in-a-canadian-context
#16
Denise S Cloutier, Margaret J Penning
PURPOSE OF THE STUDY: Janus, the two-faced, Roman god of beginnings and transitions, is used as a metaphor to explore our personal narratives and our quantitative research on the experiences of older women with dementia in long-term care (LTC). Two research questions are addressed: (a) How do our quantitative data map onto our mothers' experiences? (b) What lessons do our mothers' experiences offer for the care of older women with dementia? DESIGN AND METHODS: Informed by a life-course perspective, we triangulate administrative data on 3,717 women with dementia receiving LTC in British Columbia, Canada, with personal narratives-the stories of our mothers who made the transition from home care into residential (nursing home) care...
November 16, 2016: Gerontologist
https://www.readbyqxmd.com/read/27832209/handgrip-strength-and-factors-associated-in-poor-elderly-assisted-at-a-primary-care-unit-in-rio-de-janeiro-brazil
#17
Valéria Teresa Saraiva Lino, Nádia Cristina Pinheiro Rodrigues, Gisele O'Dwyer, Mônica Kramer de Noronha Andrade, Inês Echenique Mattos, Margareth Crisóstomo Portela
INTRODUCTION: Sarcopenia is a condition diagnosed when the patient presents low muscle mass, plus low muscle strength or low physical performance. Muscle weakness in the oldest (dynapenia) is a major public health concern because it predicts future all-cause mortality and is associated with falls, disability, cardiovascular mortality and morbidity. Grip strength is a simple method for assessment of muscle function in clinical practice. OBJECTIVE: To estimate the grip strength and identify factors associated with handgrip strength variation in elderly people with low socioeconomic status...
2016: PloS One
https://www.readbyqxmd.com/read/27816908/delirium-risk-stratification-in-consecutive-unselected-admissions-to-acute-medicine-validation-of-a-susceptibility-score-based-on-factors-identified-externally-in-pooled-data-for-use-at-entry-to-the-acute-care-pathway
#18
Sarah T Pendlebury, Nicola G Lovett, Sarah C Smith, Rose Wharton, Peter M Rothwell
BACKGROUND: recognition of prevalent delirium and prediction of incident delirium may be difficult at first assessment. We therefore aimed to validate a pragmatic delirium susceptibility (for any, prevalent and incident delirium) score for use in front-line clinical practice in a consecutive cohort of older acute medicine patients. METHODS: consecutive patients aged ≥65 years over two 8-week periods (2010-12) were screened prospectively for delirium using the Confusion Assessment Method (CAM), and delirium was diagnosed using the DSM IV criteria...
November 5, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27815111/cross-cultural-adaptation-and-validation-of-the-spanish-language-version-of-the-sarc-f-to-assess-sarcopenia-in-mexican-community-dwelling-older-adults
#19
Lorena Parra-Rodríguez, Claudia Szlejf, Ana Isabel García-González, Theodore K Malmstrom, Esteban Cruz-Arenas, Oscar Rosas-Carrasco
OBJECTIVES: To cross-culturally adapt and validate the Spanish-language version of the SARC-F in Mexican community-dwelling older adults. DESIGN: Cross-sectional analysis of a prospective cohort. SETTING: The FraDySMex study, a 2-round evaluation of community-dwelling adults from 2 municipalities in Mexico City. PARTICIPANTS: Participants were 487 men and women older than 60 years, living in the designated area in Mexico City...
December 1, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27808595/nutrition-and-the-gut-microbiome-in-the-elderly
#20
Nuria Salazar, Lorena Valdés-Varela, Sonia González, Miguel Gueimonde, Clara G de Los Reyes-Gavilán
The gut microbiota is the assembly of microorganisms living in our intestine and their genomes are known as the microbiome. The correct composition and functionality of this microbiome is essential for maintaining a "healthy status." Aging is related to changes in the gut microbiota which are frequently associated with physiological modifications of the gastrointestinal tract, as well as, to changes in dietary patterns, together with a concomitant decline in cognitive and immune function, all together contributing to frailty...
November 3, 2016: Gut Microbes
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