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Cognitive Frailty

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https://www.readbyqxmd.com/read/28925598/atrophy-of-the-parahippocampal-gyrus-is-prominent-in-heart-failure-patients-without-dementia
#1
Tomomi Meguro, Yuko Meguro, Takeyoshi Kunieda
AIMS: The exacerbation of heart failure (HF) induces brain damage and cognitive impairment (CI), which frequently attenuates the effects of treatment. However, it is not clear whether HF patients without clinical dementia demonstrate increased risk of CI. We examined whether local atrophy in the parahippocampal gyrus, a potential predictor of CI, is prominent in HF patients without clinical dementia. METHODS AND RESULTS: Twenty stable HF patients with a history of admission due to decompensated HF or presentation of apparent pulmonary congestion following chest X-ray and 17 controls were enrolled in this observational, analytical, cross-sectional, case-control study...
July 17, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28901990/the-impact-of-frailty-on-outcomes-in-dialysis
#2
John Sy, Kirsten L Johansen
: Advances in the assessment of frailty among dialysis patients have improved our understanding of the association between frailty and poor outcomes. We review recent studies that assess the association between frailty and mortality, falls and fractures, hospitalizations, cognitive impairment, and other less traditional outcomes. A greater understanding of these associations may provide more accurate prognostic information, allow tailored interventions, and improve discussions between patients and providers about the risks and benefits of the dialysis procedure...
September 9, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28898390/comprehensive-geriatric-assessment-for-older-adults-admitted-to-hospital
#3
REVIEW
Graham Ellis, Mike Gardner, Apostolos Tsiachristas, Peter Langhorne, Orlaith Burke, Rowan H Harwood, Simon P Conroy, Tilo Kircher, Dominique Somme, Ingvild Saltvedt, Heidi Wald, Desmond O'Neill, David Robinson, Sasha Shepperd
BACKGROUND: Comprehensive geriatric assessment (CGA) is a multi-dimensional, multi-disciplinary diagnostic and therapeutic process conducted to determine the medical, mental, and functional problems of older people with frailty so that a co-ordinated and integrated plan for treatment and follow-up can be developed. This is an update of a previously published Cochrane review. OBJECTIVES: We sought to critically appraise and summarise current evidence on the effectiveness and resource use of CGA for older adults admitted to hospital, and to use these data to estimate its cost-effectiveness...
September 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28866355/use-of-the-spanish-version-of-the-rapid-geriatric-assessment-in%C3%A2-mexican-patients-in-long-term-care
#4
Jorge Alberto Mena-Madrazo, Beatriz E Mariscal-Martinez, Mariana Leon-Quintero, Stephanie M Lupercio Macias
We report our experience with the use of a Spanish version of the rapid geriatric assessment of 30 patients in 2 long-term care institutions in Mexico City by a group of healthcare students without prior experience in geriatric medicine. The Spanish version of the rapid geriatric assessment is a very easy tool to administer that can provide overall good results for identifying frailty, sarcopenia, anorexia, weight loss, and cognitive impairment.
August 30, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28863199/hypertension-treatment-strategies-for-older-adults
#5
REVIEW
Maggie W Hansell, Emily M Mann, Julienne K Kirk
This evidence-based review illustrates how to adjust treatment for comorbidities and incorporate frailty and cognitive impairment into the equation.
September 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28860729/aging-and-extrapulmonary-effects-of-chronic-obstructive-pulmonary-disease
#6
Emanuela Tudorache, Ariadna Petronela Fildan, Mirela Frandes, Elena Dantes, Doina Ecaterina Tofolean
INTRODUCTION: People with COPD have a decline in functional status, but little is known about the rate of decline and factors that contribute. Of particular concern is the decline in cognitive and functional performance. Decrease in cognitive and functional performance will finally lead to decreased health status, sedentary life style and premature frailty. AIM: The aim of this study is to compare functional performance and cognitive status in patients with COPD of different ages and to examine the changes in extrapulmonary effects...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28860112/risk-factors-for-falls-in-older-patients-with-cancer
#7
Xiaotao Zhang, Ming Sun, Suyu Liu, Cheuk Hong Leung, Linda Pang, Uday R Popat, Richard Champlin, Holly M Holmes, Vicente Valero, Colin P Dinney, Debu Tripathy, Beatrice J Edwards
OBJECTIVES: A rising number of patients with cancer are older adults (65 years of age and older), and this proportion will increase to 70% by the year 2020. Falls are a common condition in older adults. We sought to assess the prevalence and risk factors for falls in older patients with cancer. METHODS: This is a single-site, retrospective cohort study. Patients who were receiving cancer care underwent a comprehensive geriatric assessments, including cognitive, functional, nutritional, physical, falls in the prior 6 months and comorbidity assessment...
August 31, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28854882/a-four-domain-approach-of-frailty-explored-in-the-doetinchem-cohort-study
#8
Sandra H van Oostrom, Daphne L van der A, M Liset Rietman, H Susan J Picavet, Manon Lette, W M Monique Verschuren, Simone R de Bruin, Annemieke M W Spijkerman
BACKGROUND: Accumulation of problems in physical, psychological, cognitive, or social functioning is characteristic for frail individuals. Using a four-domain approach of frailty, this study explored how sociodemographic and lifestyle factors, life events and health are associated with frailty. METHODS: The study sample included 4019 men and women (aged 40-81 years) examined during the fifth round (2008-2012) of the Doetinchem Cohort Study. Four domains of frailty were considered: physical (≥4 of 8 criteria: unintentional weight loss, exhaustion, strength, perceived health, walking, balance, hearing and vision impairments), psychological (2 criteria: depressive symptoms, mental health), cognitive (<10th percentile on global cognitive functioning), and social frailty (≥2 of 3 criteria: loneliness, social support, social participation)...
August 30, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28853612/foot-problems-in-older-adults-associations-with-incident-falls-frailty-syndrome-and-sensor-derived-gait-balance-and-physical-activity-measures
#9
Amy Muchna, Bijan Najafi, Christopher S Wendel, Michael Schwenk, David G Armstrong, Jane Mohler
BACKGROUND: Research on the relationship between foot problems and frailty is sparse and could be elucidated via advances in wearable sensor-based measures of gait, balance, and physical activity (PA). This study examined the impact of foot problems on likelihood of falls, frailty syndrome, motor performance, and PA in community-dwelling older adults. METHODS: Arizona Frailty Cohort Study participants (community-dwelling adults 65 years and older without baseline cognitive deficit, severe movement disorders, or recent stroke) underwent Fried frailty and foot assessment...
August 30, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28844857/pathways-from-physical-frailty-to-activity-limitation-in-older-people-identifying-moderators-and-mediators-in-the-english-longitudinal-study-of-ageing
#10
Yew Y Ding, Jouni Kuha, Michael Murphy
Physical frailty increases the risk of future activity limitation, which in turn, compromises independent living of older people and limits their healthspan. Thus, we seek to identify moderators and mediators of the effect of physical frailty on activity limitation change in older people, including gender- and age-specific effects. In a longitudinal study using data from waves 2, 4, and 6 of the English Longitudinal Study of Ageing, unique physical frailty factor scores of 4638 respondents aged 65 to 89years are obtained from confirmatory factor analysis of physical frailty, which is specified by three indicators, namely slowness, weakness, and exhaustion...
August 26, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28843528/cognitive-frailty-far-from-clinical-and-research-adoption
#11
EDITORIAL
Marco Canevelli, Matteo Cesari
No abstract text is available yet for this article.
August 23, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28843526/validation-of-the-korean-version-of-the-sarc-f-questionnaire-to-assess-sarcopenia-korean-frailty-and-aging-cohort-study
#12
Sunyoung Kim, Miji Kim, Chang Won Won
OBJECTIVES: The SARC-F is a simple sarcopenia screening tool comprising 5 assessment items: strength, assistance walking, rising from a chair, climbing stairs, and falls. The present study aimed to examine the validation of the Korean version of SARC-F for elderly individuals residing in communities. SETTING AND PARTICIPANTS: From the first year baseline data of Korean Frailty and Aging Cohort Study, a total of 1222 elderly individuals (70 years and older) who met the study's selection criteria were included in the analysis...
August 23, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28835211/handgrip-strength-values-of-portuguese-older-adults-a-population-based-study
#13
Joana Mendes, Teresa F Amaral, Nuno Borges, Alejandro Santos, Patrícia Padrão, Pedro Moreira, Cláudia Afonso, Rita Negrão
BACKGROUND: Handgrip strength is used to identify sarcopenia and frailty phenotypes, being a potential predictor of mortality in older adults. However, uniformity is lacking in the reference values. This study aimed to describe handgrip strength values of older population aged ≥65 years in Portugal, considering the possible influence of anthropometric parameters. METHODS: A cross-sectional study was conducted in Portugal, among 1500 older adults aged ≥65 years old, according to "The Nutrition UP 65 Study Protocol"...
August 23, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28826805/cognitive-impairment-and-overall-survival-in-frail-surgical-patients
#14
Salima S Makhani, Frances Y Kim, Yuan Liu, Zixun Ye, Jessica L Li, Louis M Revenig, Camille P Vaughan, Theodore M Johnson, Paul S García, Kenneth Ogan, Viraj A Master
BACKGROUND: The definition of frailty, as modeled by the Fried criteria, has been limited primarily to the physical domain. The purpose of this study was to assess the additive value of cognitive function with existing frailty criteria to predict poor postoperative outcomes in a large multidisciplinary cohort of patients undergoing major surgery. STUDY DESIGN: A four-level composite frailty scoring system was created via the combination of the Fried Frailty score and the Emory clock draw test to assess preoperative frailty and cognitive impairment, respectively...
August 4, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28822920/are-frailty-components-associated-with-disability-in-specific-activities-of-daily-living-in-community-dwelling-older-adults-a-multicenter-canadian-study
#15
Véronique Provencher, François Béland, Louise Demers, Johanne Desrosiers, Nathalie Bier, José Alberto Ávila-Funes, Claude Galand, Dominic Julien, John D Fletcher, Lise Trottier, Benyahia Hami
Current studies show the relevance of geriatric prevention and rehabilitation programs to slow down the development of disability in community-dwelling older adults who are becoming frail. This evidence reveals the importance of improving knowledge on how individual components of frailty and specific disability in basic and instrumental activities of daily living (ADL) are related, to offer early, targeted, and tailored interventions. The objective was to examine the association between each of the five frailty phenotype components (weakness, slowness, exhaustion, low physical activity, weight loss) and disability in specific ADL pertaining to physical aspects (bathing, dressing, cutting toe nails, transportation, shopping, housekeeping, food purchasing, food preparation) and cognitive aspects (finances, telephone, medication)...
August 2, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28808093/are-disagreements-in-caregiver-and-patient-assessment-of-patient-health-associated-with-increased-caregiver-burden-in-caregivers-of-older-adults-with-cancer
#16
Tina Hsu, Matthew Loscalzo, Rupal Ramani, Stephen Forman, Leslie Popplewell, Karen Clark, Vani Katheria, Rex Strowbridge, Redmond Rinehart, Dan Smith, Keith Matthews, Jeff Dillehunt, Tao Feng, David Smith, Canlan Sun, Arti Hurria
BACKGROUND: As patients age, caregivers increasingly provide essential support and patient information. We sought to determine if patient-caregiver assessments of patient health differ and if differences contribute to burden in caregivers of older adults with cancer. MATERIALS AND METHODS: One hundred patients, aged ≥65, and their caregivers independently assessed patient function, comorbidity, nutrition, social activity, social support, and mental health. Caregivers completed the Caregiver Strain Index (CSI)...
August 14, 2017: Oncologist
https://www.readbyqxmd.com/read/28799502/mitochondrial-dynamics-and-proteins-related-to-neurodegenerative-diseases
#17
Athanasios Alexiou, Bilal Nizami, Faez Iqbal Khan, Georgia Soursou, Charalampos Vairaktarakis, Stylianos Chatzichronis, Vasilis Tsiamis, Vasileios Manztavinos, Nagendra Sastry Yarla, Ghulam Md Ashraf
Disruptions in the regulation of mitochondrial dynamics and the occurrence of proteins misfolding lead to neuronal death, resulting in Age-related Dementia and Neurodegenerative diseases as well as Frailty. Functional, neurophysiologic and biochemical alterations within the mitochondrial populations can reveal deficits in brain energy metabolism resulting in Mild Cognitive Impairment, abnormal neural development, autonomic dysfunction and other mitochondrial disorders. Additionally, in cases of Alzheimer's disease or Parkinson's disease, a significant number of proteins seems to form unordered and problematic structures, leading through unknown mechanisms to pathological conditions...
August 10, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28798152/self-reported-vision-impairment-and-incident-prefrailty-and-frailty-in-english-community-dwelling-older-adults-findings-from-a-4-year-follow-up-study
#18
Ann E M Liljas, Livia A Carvalho, Efstathios Papachristou, Cesar De Oliveira, S Goya Wannamethee, Sheena E Ramsay, Kate R Walters
BACKGROUND: Little is known about vision impairment and frailty in older age. We investigated the relationship of poor vision and incident prefrailty and frailty. METHODS: Cross-sectional and longitudinal analyses with 4-year follow-up of 2836 English community-dwellers aged ≥60 years. Vision impairment was defined as poor self-reported vision. A score of 0 out of the 5 Fried phenotype components was defined as non-frail, 1-2 prefrail and ≥3 as frail. Participants non-frail at baseline were followed-up for incident prefrailty and frailty...
August 10, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28797589/association-between-frailty-and-cognitive-impairment-cross-sectional-data-from-toulouse-frailty-day-hospital
#19
Bertrand Fougère, Matthieu Daumas, Matthieu Lilamand, Sandrine Sourdet, Julien Delrieu, Bruno Vellas, Gabor Abellan van Kan
BACKGROUND: A consensus panel, based on epidemiologic evidence, argued that physical frailty is often associated with cognitive impairment, possibly because of common underlying pathophysiological mechanisms. The concepts of cognitive frailty and motoric cognitive risk were recently proposed in literature and may represent a prodromal stage for neurodegenerative diseases. The purpose of this study was to analyze the relationship between cognition and the components of the physical phenotype of frailty...
August 7, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28794619/grip-strength-as-a-frailty-diagnostic-component-in-geriatric-inpatients
#20
Joanna Dudzińska-Griszek, Karolina Szuster, Jan Szewieczek
BACKGROUND: Frailty has emerged as a key medical syndrome predictive of comorbidity, disability, institutionalization and death. As a component of the five frailty phenotype diagnostic criteria, patient grip strength deserves attention as a simple and objective measure of the frailty syndrome. The aim of this study was to assess conditions that influence grip strength in geriatric inpatients. PATIENTS AND METHODS: The study group consisted of 80 patients aged 78...
2017: Clinical Interventions in Aging
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