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Cognitive Frailty

Taiki Sugimoto, Takashi Sakurai, Rei Ono, Ai Kimura, Naoki Saji, Shumpei Niida, Kenji Toba, Liang-Kung Chen, Hidenori Arai
Since the operational definition of "cognitive frailty" was first proposed in 2013 by the International Academy of Nutrition and Aging and the International Association of Gerontology and Geriatrics, several studies have been carried out using this cognitive frailty model. In this review, we examined the available clinical and epidemiological evidence for cognitive frailty. Despite its low prevalence (1.0-1.8%) in the community setting, cognitive frailty has been associated with a high risk of disability, poor quality of life, and death; while cognitive frailty appears to be associated with a high risk of dementia, there is no clear evidence for this association...
March 12, 2018: Ageing Research Reviews
Tomas L Griebling
No abstract text is available yet for this article.
May 2017: Journal of Urology
Albert Ariza-Solé, Carme Guerrero, Francesc Formiga, Jaime Aboal, Emad Abu-Assi, Francisco Marín, Héctor Bueno, Oriol Alegre, Ramón López-Palop, María T Vidán, Manuel Martínez-Sellés, Pablo Díez-Villanueva, Pau Vilardell, Alessandro Sionis, Miquel Vives-Borrás, Juan Sanchís, Jordi Bañeras, Agnès Rafecas, Cinta Llibre, Javier López, Violeta González-Salvado, Àngel Cequier
BACKGROUND:  Bleeding risk scores have shown a limited predictive ability in elderly patients with acute coronary syndromes (ACS). No study explored the role of a comprehensive geriatric assessment to predict in-hospital bleeding in this clinical setting. METHODS:  The prospective multicentre LONGEVO-SCA registry included 532 unselected patients with non-ST segment elevation ACS (NSTEACS) aged 80 years or older. Comorbidity (Charlson index), frailty (FRAIL scale), disability (Barthel index and Lawton-Brody index), cognitive status (Pfeiffer test) and nutritional risk (mini nutritional assessment-short form test) were assessed during hospitalization...
March 2018: Thrombosis and Haemostasis
Paulo Giusti Rossi, Larissa Pires de Andrade, Juliana Hotta Ansai, Ana Claudia Silva Farche, Leticia Carnaz, Daniela Dalpubel, Eduardo Ferriolli, Francisco Assis Carvalho Vale, Anielle Cristhine de Medeiros Takahashi
BACKGROUND AND PURPOSE: Cognition and level of physical activity have been associated with frailty syndrome. The development of tools that assess deficits related to physical and cognitive frailties simultaneously are of common interest. However, little is known about how much these aspects influence the performance of dual-task tests. Our aims were (a) to verify the influence of frailty syndrome and objectively measured physical activity and cognition on the Timed Up and Go (TUG) test and Timed Up and Go associated with dual-task (TUG-DT) performances; and (b) to compare TUG and TUG-DT performances between older adults who develop frailty syndrome...
March 8, 2018: Journal of Geriatric Physical Therapy
Gila Albert, Tsippy Lotan, Penina Weiss, Yoram Shiftan
The challenge of ageing has two key aspects with regard to driving: mobility and safety. It is necessary for elderly adults to preserve independent mobility and activity; however, physical frailty and cognitive limitations have negative effects on their safety. Therefore, the issue of driving, and more specifically, the fostering of safe driving of old people, is crucial, especially due the increasing number of elderly people holding a driving license. The purpose of this Letter is to point out the complexity of elderly driving and to suggest countermeasures by acknowledging that obtaining the correct balance between safety and mobility of older drivers is a complicated and sensitive task...
February 2018: Healthcare Technology Letters
Sarah M Gilbert, Lynne Nemeth, Elaine Amella, Barbara Edlund, Virginia Burggraf
This study explores the experiences of adult children as they transition their functionally and/or cognitively declining aging parents from independent living to supervised housing. A qualitative grounded theory approach was used to chronicle the experiences of adult children as their caregiving responsibilities intensified and their parents' health declined. Purposive, snowball sampling was used to enlist adult children (n = 16) who were in the process of transitioning an aging parent from an independent living situation to one providing assistance with everyday care and tasks...
March 5, 2018: Issues in Mental Health Nursing
Fan Yang, Qing-Wei Chen
We assessed the frailty status of inpatients and analyzed the factors influencing frailty status to explore the reasons for frailty and identify feasible intervention strategies.A total of 1494 geriatric patients aged ≥60 years were recruited as subjects. All patients were hospitalized between September 2014 and August 2015 in the internal medicine units of 3 hospitals in Chongqing and Zunyi in the southwestern area of China. Patients' frailty status was evaluated using the Phenotype of Frailty scale, via face-to-face interviews coupled with physical examinations using simple equipment...
January 2018: Medicine (Baltimore)
Maurizio Gallucci, Cinzia Piovesan, Maria Elena Di Battista
BACKGROUND: Frailty is a condition which is characterized by a reduction in the homeostatic reserves of the individual and which entails an increased vulnerability to stressful endogenous and exogenous agents. The Frailty Index (FI), proposed by Rockwood, was designed following an accumulation of deficits model: the greater the number of deficits in a given individual, the greater the degree of frailty. OBJECTIVE: The aim of this study was to verify the existence of associations between FI and cerebral atrophy...
February 28, 2018: Journal of Alzheimer's Disease: JAD
Stefanos Tyrovolas, Noe Garin Escriva, Jose Luis Ayuso-Mateos, Somnath Chatterji, Ai Koyanagi, Marta Miret, Moneta Victoria, Beatriz Olaya, Beata Tobiasz-Adamczyk, Seppo Koskinen, Matilde Leonardi, Josep Maria Haro
BACKGROUND AND AIM: Frailty is characterized by several deficits in multiple health related domains. Although cognition is among the important components of frailty, there is lack of evidence on the role of specific neuro-cognitive dimensions. The primary aim of the present work was to evaluate the multidimensional definition of frailty, and to assess whether neuro-cognitive function is a constituent of the frailty syndrome among adults aged ≥50 years living in three European countries...
February 27, 2018: Experimental Gerontology
Tammy T Hshieh, Wooram F Jung, Laura J Grande, Jiaying Chen, Richard M Stone, Robert J Soiffer, Jane A Driver, Gregory A Abel
Importance: As the population ages, cognitive impairment has promised to become increasingly common among patients with cancer. Little is known about how specific domains of cognitive impairment may be associated with survival among older patients with hematologic cancers. Objective: To determine the prevalence of domain-specific cognitive impairment and its association with overall survival among older patients with blood cancer. Design, Setting, and Participants: This prospective observational cohort study included all patients 75 years and older who presented for initial consultation in the leukemia, myeloma, or lymphoma clinics of a large tertiary hospital in Boston, Massachusetts, from February 1, 2015, to March 31, 2017...
March 1, 2018: JAMA Oncology
K Motokawa, Y Watanabe, A Edahiro, M Shirobe, M Murakami, T Kera, H Kawai, S Obuchi, Y Fujiwara, K Ihara, Y Tanaka, H Hirano
Providing older person individuals with an appropriate intervention at the time of frailty onset is important to prevent the progression of the condition and the need for long-term care. However, the proper timing of starting nutritional and dietary interventions for frail older person subjects has not been fully elucidated. Therefore, in this cross-sectional study, we aimed to clarify the association between frailty and dietary variety among older persons in Japan. We surveyed sex, age, body height, body weight, body mass index, serum albumin level, dietary variety, and nutritional intake indexes in 747 community-dwelling older person individuals who underwent a comprehensive health examination in October 2014...
2018: Journal of Nutrition, Health & Aging
Rodrigo Z Megale, Manuela L Ferreira, Paulo H Ferreira, Vasi Naganathan, Robert Cumming, Vasant Hirani, Louise M Waite, Markus J Seibel, David G Le Couteur, David J Handelsman, Fiona M Blyth
Objectives: to determine whether pain increases the risk of developing the frailty phenotype and whether frailty increases the risk of developing chronic or intrusive pain, using longitudinal data. Design/Setting: longitudinal data from the Concord Health and Ageing in Men Project (CHAMP), a prospective population based cohort study. Participants: a total of 1,705 men aged 70 years or older, living in an urban area of New South Wales, Australia...
February 21, 2018: Age and Ageing
Márlon J R Aliberti, Daniel Apolinario, Claudia K Suemoto, Juliana A Melo, Sileno Q Fortes-Filho, Marcos D Saraiva, Carolina B Trindade, Kenneth E Covinsky, Wilson Jacob-Filho
OBJECTIVES: To develop and examine the validity and reliability of a targeted geriatric assessment (TaGA) for busy healthcare settings. DESIGN: The TaGA was developed through the consensus of experts (Delphi technique), and we investigated its construct validity and reliability in a cross-sectional study. SETTING: Geriatric day hospital specializing in acute care in Brazil. PARTICIPANTS: Older adults (N = 534) aged 79...
February 23, 2018: Journal of the American Geriatrics Society
Andreas W Schoenenberger, André Moser, Dominic Bertschi, Peter Wenaweser, Stephan Windecker, Thierry Carrel, Andreas E Stuck, Stefan Stortecky
OBJECTIVES: This study sought to evaluate whether frailty improves mortality prediction in combination with the conventional scores. BACKGROUND: European System for Cardiac Operative Risk Evaluation (EuroSCORE) or Society of Thoracic Surgeons (STS) score have not been evaluated in combined models with frailty for mortality prediction after transcatheter aortic valve replacement (TAVR). METHODS: This prospective cohort comprised 330 consecutive TAVR patients ≥70 years of age...
February 26, 2018: JACC. Cardiovascular Interventions
Dirk Müller-Wieland
Diabetes in older adults has a high prevalence and is frequently associated with comorbidities of the cardiovascular system, dysfunction of cognition as well as depression and impaired mobility or increased frailty. Furthermore, impaired renal function, heart failure, risk for hypoglycemia and polypharmacy has to be considered in the decision about the diabetes treatment strategy. The goal of blood glucose management is driven by patient relevant issues and patient self-esteem, quality of life defined by the patient, preservation of physical and social mobility rather than potential long-term effects on reduction of cardio- and microvascular events in the future, which is limited by patient-inherent reduced life expectancy of the aged individual...
February 2018: Deutsche Medizinische Wochenschrift
Jaspreet Bhangu, Patricia Hall, Naomi Devaney, Kathleen Bennett, Laura Carroll, Rose-Anne Kenny, C Geraldine McMahon
AIM: There is growing evidence of an overlap between unexplained falls and syncope in older adults. Our aim was to examine the prevalence and associated resource utilization of these conditions in an urban emergency department (ED). PATIENTS AND METHODS: A single-centre, prospective, observational study was carried out over a 6-month period. Consecutive patients older than 50 years who presented to the ED because of a fall, collapse or syncope were included. Univariate analysis of demographic data is presented as percentages, mean (SD), 95% confidence intervals (CIs) and medians (interquartile range)...
February 20, 2018: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
M Kurkcu, R I Meijer, S Lonterman, M Muller, M A E de van der Schueren
BACKGROUND: Frailty is a common clinical syndrome in older adults and is associated with an increased risk of poor health outcomes, e.g. falls, disability, hospitalization, and mortality. Nutritional status might be an important factor contributing to frailty. This study aims to describe the association between nutritional status and characteristics of frailty in patients attending a geriatric outpatient clinic. METHODS: Clinical data was collected of 475 patients who visited the geriatric outpatient department of a Dutch hospital between 2005 and 2010...
February 2018: Clinical Nutrition ESPEN
Jing-Hui Chiou, Li-Kuo Liu, Wei-Ju Lee, Li-Ning Peng, Liang-Kung Chen
OBJECTIVES: The main aim was to investigate the complex inter-relationship between frailty and pain, and the mediating roles of cognitive function, morbidity and mood in this nexus. DESIGN: A cross-sectional analysis. SETTING: A prospective community-dwelling population-based cohort. PARTICIPANTS: 1682 adults age ≥50 years without evident cognitive or functional impairment, or history of cancer. PRIMARY AND SECONDARY OUTCOME MEASURES: The mediating effect of depression, cognitive function and comorbidity on the nexus between pain and frailty among older and middle-aged adults...
February 16, 2018: BMJ Open
A R Hoeksema, L L Peters, G M Raghoebar, H J A Meijer, A Vissink, A Visser
OBJECTIVE: To assess oral health, health, and quality of life (QoL) of care-dependent community-living older people with and without remaining teeth who recently received formal home care. MATERIALS AND METHODS: For this cross-sectional observational study, community-living older people (≥ 65 years), who recently (< 6 months) received formal home care, were interviewed with validated questionnaires and underwent an oral examination. Oral health, general health, medicines usage, frailty (Groningen Frailty Indicator), cognition (Minimal Mental State Examination), QoL (RAND 36), and oral health-related QoL (Oral Health Impact Profile-14) were assessed...
February 15, 2018: Clinical Oral Investigations
Jill Nawrot, Annelies Boonen, Ralph Peeters, Mirian Starmans, Marloes van Onna
OBJECTIVE: In this qualitative study we analyzed the (1) influence of age, comorbidity, and frailty on management goals in elderly patients with RA; (2) experiences of rheumatologists regarding the use of the Disease Activity Score at 28 joints (DAS28) to monitor disease activity; and (3) differences in management strategies in elderly patients with RA compared to their younger counterparts. METHODS: Rheumatologists were purposively sampled for a semistructured interview...
February 15, 2018: Journal of Rheumatology
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