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Apoptosis

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https://www.readbyqxmd.com/read/28655163/microrna-21a-5p-pdcd4-axis-regulates-mesenchymal-stem-cell-induced-neuroprotection-in-acute-glaucoma
#1
Wenru Su, Zuohong Li, Yu Jia, Yingting Zhu, Wenjia Cai, Peixing Wan, Yingying Zhang, Song Guo Zheng, Yehong Zhuo
Mesenchymal stem cells (MSCs) have been demonstrated to have promising therapeutic benefits for a variety of neurological diseases; however, the underlying mechanisms are poorly understood. Here, we showed that intravitreal infusion of MSCs promoted retinal ganglion cell (RGC) survival in a mouse model of acute glaucoma, with significant inhibition of microglial activation, production of TNF-α, IL-1β, and reactive oxygen species, as well as caspase-8 and caspase-3 activation. In vitro, MSCs inhibited both caspase-8-mediated RGC apoptosis and microglial activation, partly via the action of stanniocalcin 1 (STC1)...
June 26, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28655132/fstl1-contributes-to-tumor-progression-via-attenuating-apoptosis-in-a-akt-gsk-3%C3%AE-dependent-manner-in-hepatocellular-carcinoma
#2
Wei Yang, Yaqi Wu, Cong Wang, Zhikui Liu, Meng Xu, Xin Zheng
BACKGROUND: Several investigations have demonstrated that follistatin-like 1 (FSTL1) is implicated in the initiation and progression of diverse cancers. It remains unclear whether FSTL1 acted as a cancer-promoting gene through its overexpression in HCC. PATIENTS AND METHODS: We detected FSTL1 protein expression in 210 consecutive HCC cases curatively resected in our hospital between 2004 and 2007. The correlation between FSTL1 expression in HCC tissues and post-surgical prognosis of HCCs was analyzed...
May 26, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28655090/-molecular-mechanisms-and-relationship-of-m2-polarized-macrophages-with-early-response-in-multiple-myeloma
#3
X Y Chen, R X Sun, W Y Zhang, T Liu, Y H Zheng, Y Wu
Objective: To investigate the relationship between M2-polarized macrophages and early response in multiple myeloma and its molecular mechanism. Methods: Two hundred and forty bone marrow biopsy tissue were collected and M2-polarized macrophages were stained by anti-CD163 monoclonal antibody. In vitro M2-polarized macrophages were derived from human peripheral blood mononuclear cell or THP-1 cells and identified by flow cytometry. Two myeloma cell lines RPMI 8226 and U266 were co-cultured with M2 macrophages using a transwell system...
June 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28654910/microrna16-regulates-glioma-cell-proliferation-apoptosis-and-invasion-by-targeting-wip1-atm-p53-feedback-loop
#4
Xiao-Hong Zhan, Qiu-Yan Xu, Rui Tian, Hong Yan, Min Zhang, Jing Wu, Wei Wang, Jie He
The present study aimed to investigate the role and underlying mechanisms of microRNA16 (miR-16) on proliferation, apoptosis and invasion of glioma cells. The cell models of miR-16 upregulation and Negative control group (NC group) were built. The cell functions of different groups were detected by colony formation assay, transwell chamber assay, proliferation, apoptosis and cycle experiments. The intracranial orthotopic transplantation animal models were built to different groups: miR-16 agomir group, miR-16 antagomir group and their NC group...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654908/apio-ee-9-is-a-novel-aurora-a-and-b-antagonist-that-suppresses-esophageal-cancer-growth-in-a-pdx-mouse-model
#5
Guoguo Jin, Ke Yao, Zhiping Guo, Zhenjiang Zhao, Kangdong Liu, Fangfang Liu, Hanyong Chen, Dhilli Rao Gorja, Kanamata Reddy, Ann M Bode, Ziming Dong, Zigang Dong
Esophageal cancer (EC) is one of the most aggressive malignancies of the upper aerodigestive tract. Over the past three decades, with advances in surgical techniques and treatment, the prognosis of esophageal cancer has only slowly improved. Thus identifying novel molecular targets and developing therapeutic agents are critical. Aurora kinases play a crucial role in mitosis and selective inhibitors might provide an effective therapeutic treatment for cancer. However, the role of Aurora kinases in EC is still inadequately studied...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654905/microrna-107-5p-suppresses-non-small-cell-lung-cancer-by-directly-targeting-oncogene-epidermal-growth-factor-receptor
#6
Ping Wang, Xiaomin Liu, Yang Shao, Huimin Wang, Chen Liang, Baohui Han, Zhongliang Ma
MicroRNAs (miRNAs) are dysregulated in cancers, including human non-small cell lung cancer (NSCLC). The function of MicroRNA-107-5p (miR-107-5p) in NSCLC is not fully elucidated. Epidermal growth factor receptor (EGFR) is a cancer-driven gene in tumorigenesis. In this study, we found that miR-107-5p was significantly decreased in NSCLC tissues and NSCLC cell lines. Moreover, our results indicated that miR-107-5p could suppress cell proliferation, inhibit metastasis, impede cell cycle, and promote apoptosis via directly targeting EGFR...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654902/cryptotanshinone-inhibits-proliferation-yet-induces-apoptosis-by-suppressing-stat3-signals-in-renal-cell-carcinoma
#7
Zhiguo Chen, Rujian Zhu, Jiayi Zheng, Chen Chen, Chi Huang, Junjie Ma, Chen Xu, Wei Zhai, Junhua Zheng
It has been established that signal transducer and activator of transcription 3 serves as an oncoprotein in various human cancers; targeting it is therefore a reasonable approach for emerging cancer therapies. Cryptotanshinone, a natural compound extracted from the root of Salvia miltiorrhiza Bunge, has been identified as a potential STAT3 inhibitor. However, its functional role in renal cell carcinomas remains largely unknown. Therefore, we investigated the mode of action for cryptotanshinone. We found that cryptotanshinone substantially suppressed cancer cell growth while it promoted cell apoptosis by inhibiting the phosphorylation of STAT3 at Tyr705 and its blocking nuclear translocation...
June 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654894/therapeutic-utility-of-natural-estrogen-receptor-beta-agonists-on-ovarian-cancer
#8
Jinyou Liu, Suryavathi Viswanadhapalli, Lauren Garcia, Mei Zhou, Binoj C Nair, Edward Kost, Rajeshwar Rao Tekmal, Rong Li, Manjeet K Rao, Tyler Curiel, Ratna K Vadlamudi, Gangadhara R Sareddy
Ovarian cancer is the deadliest of all gynecologic cancers. Despite success with initial chemotherapy, the majority of patients relapse with an incurable disease. Development of chemotherapy resistance is a major factor for poor long-term survival in ovarian cancer. The biological effects of estrogens are mediated by estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). Emerging evidence suggests that ovarian cancer cells express ERβ that functions as a tumor suppressor; however, the clinical utility of ERβ agonists in ovarian cancer remains elusive...
June 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654892/intrinsic-remote-conditioning-of-the-myocardium-as-a-comprehensive-cardiac-response-to-ischemia-and-reperfusion
#9
Noemi Pavo, Dominika Lukovic, Katrin Zlabinger, David Lorant, Georg Goliasch, Johannes Winkler, Dietmar Pils, Katharina Auer, Hendrik Jan Ankersmit, Zoltán Giricz, Márta Sárközy, András Jakab, Rita Garamvölgyi, Maximilian Y Emmert, Simon P Hoerstrup, Derek J Hausenloy, Péter Ferdinandy, Gerald Maurer, Mariann Gyöngyösi
We have previously shown that distal anterior wall ischemia/reperfusion induces gene expression changes in the proximal anterior myocardial area, involving genes responsible for cardiac remodeling. Here we investigated the molecular signals of the ischemia non-affected remote lateral and posterior regions and present gene expression profiles of the entire left ventricle by using our novel and straightforward method of 2D and 3D image reconstruction. Five or 24h after repetitive 10min ischemia/reperfusion without subsequent infarction, pig hearts were explanted and myocardial samples from 52 equally distributed locations of the left ventricle were collected...
June 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654818/high-throughput-screening-of-myxoid-liposarcoma-cell-lines-survivin-is-essential-for-tumor-growth
#10
Marieke A de Graaff, Shruti Malu, Irma Guardiola, Alwine B Kruisselbrink, Yvonne de Jong, Willem E Corver, H Gelderblom, Patrick Hwu, Torsten O Nielsen, Alexander J Lazar, Neeta Somaiah, Judith V M G Bovée
Myxoid liposarcoma (MLS) is a soft tissue sarcoma characterized by a recurrent t(12;16) translocation. Although tumors are initially radio- and chemosensitive, the management of inoperable or metastatic MLS can be challenging. Therefore, our aim was to identify novel targets for systemic therapy. We performed an in vitro high-throughput drug screen using three MLS cell lines (402091, 1765092, DL-221), which were treated with 273 different drugs at four different concentrations. Cell lines and tissue microarrays were used for validation...
June 24, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28654762/jatropha-6-17-11e-diene-class-derivatives-induce-apoptosis-effects-in-ovcar-3-and-caov-4-ovarian-cancer-cell-lines-via-mitochondrial-pathway
#11
Behzad Bahmani, Mohammad Keyvanloo Shahrestanaki, Mustafa Ghanadian, Sima Hajiahmadi, Mahmoud Aghaei
We investigated the molecular mechanism of apoptosis induced by novel jatropha-6(17),11E-diene class derivatives, compounds A, B, and C extracted from Euphorbia osyridea in Caov-4 and OVCAR-3 ovarian cancer cell lines. OVCAR-3 and Caov-4 cell lines were treated with different concentrations of these compounds. Cytotoxicity was evaluated by MTT, clonogenic survival assay and Flow cytometry assays. ROS production, mitochondrial membrane potential (ΔΨm), Caspase 3 and 9 activities were evaluated. Compound A, B, and C reduced cell viability in a dose-dependent manner (P<0...
June 27, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28654704/2-5-hexanedione-downregulates-nerve-growth-factor-and-induces-neuron-apoptosis-in-the-spinal-cord-of-rats-via-inhibition-of-the-pi3k-akt-signaling-pathway
#12
Zhemin Wang, Zewen Qiu, Chenxue Gao, Yijie Sun, Wei Dong, Yan Zhang, Ruolin Chen, Yuan Qi, Shuangyue Li, Yanjie Guo, Yongjun Piao, Sheng Li, Fengyuan Piao
2,5-hexanedione (2,5-HD) is the main active metabolite of n-hexane and induces apoptosis in nerve tissue, however, the mechanism of which remains unclear. In the present study, neuropathic animal models were successfully constructed in rats by injecting 100, 200 and 400 mg/kg 2,5-HD intraperitoneally for 5 weeks. Rats exposed to 2,5-HD exhibited progressive gait abnormalities and slower motor neural response in a dose-dependent manner. TUNEL analysis and immunofluorescence dual labeling revealed that the spinal cord of the 2,5-HD treated rats underwent significantly more apoptosis in the cells of spinal cord than that of the control group...
2017: PloS One
https://www.readbyqxmd.com/read/28654697/correction-a-physically-modified-saline-suppresses-neuronal-apoptosis-attenuates-tau-phosphorylation-and-protects-memory-in-an-animal-model-of-alzheimer-s-disease
#13
Khushbu K Modi, Arundhati Jana, Supurna Ghosh, Richard Watson, Kalipada Pahan
[This corrects the article DOI: 10.1371/journal.pone.0103606.].
2017: PloS One
https://www.readbyqxmd.com/read/28654695/fate-of-tenogenic-differentiation-potential-of-human-bone-marrow-stromal-cells-by-uniaxial-stretching-affected-by-stretch-activated-calcium-channel-agonist-gadolinium
#14
Hui Yin Nam, Hanumantha Rao Balaji Raghavendran, Belinda Pingguan-Murphy, Azlina A Abbas, Azhar M Merican, Tunku Kamarul
The role for mechanical stimulation in the control of cell fate has been previously proposed, suggesting that there may be a role of mechanical conditioning in directing mesenchymal stromal cells (MSCs) towards specific lineage for tissue engineering applications. Although previous studies have reported that calcium signalling is involved in regulating many cellular processes in many cell types, its role in managing cellular responses to tensile loading (mechanotransduction) of MSCs has not been fully elucidated...
2017: PloS One
https://www.readbyqxmd.com/read/28654421/correction-traf2-regulates-tnf-and-nf-%C3%AE%C2%BAb-signalling-to-suppress-apoptosis-and-skin-inflammation-independently-of-sphingosine-kinase-1
#15
Nima Etemadi, Michael Chopin, Holly Anderton, Maria C Tanzer, James A Rickard, Waruni Abeysekera, Cathrine Hall, Sukhdeep K Spall, Bing Wang, Yuquan Xiong, Timothy Hla, Stuart M Pitson, Claudine S Bonder, Wendy Wei-Lynn Wong, Matthias Ernst, Gordon K Smyth, David L Vaux, Stephen L Nutt, Ueli Nachbur, John Silke
No abstract text is available yet for this article.
June 27, 2017: ELife
https://www.readbyqxmd.com/read/28654382/imaging-of-myocardial-ischemia-reperfusion-injury-using-sodium-18-f-fluoride-positron-emission-tomography-computed-tomography-in-rats-and-humans
#16
Hongyoon Choi, Jeong Hee Han, Sue Yeon Lim, Inki Lee, Young-Seok Cho, Eun Ju Chun, Won Woo Lee
Positron emission tomography (PET)/computed tomography (CT) using sodium [(18)F]fluoride (Na[(18)F]F) has been proven to be a promising hot-spot imaging modality for myocardial infarction (MI). We investigated Na[(18)F]F uptake in ischemia-reperfusion injury (IRI) of rats and humans. Sodium [(18)F]fluoride PET/CT was performed in Sprague-Dawley rats that had IRI surgery, and it readily demonstrated prominent Na[(18)F]F uptake in the infarct area post-IRI. Sodium [(18)F]fluoride uptake was matched with negative 2,3,5-triphenyl-2 H-tetrazolium chloride staining results, accompanied by myocardial apoptosis and associated with positive calcium staining results...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654376/preclinical-evaluation-of-18-f-ml-10-to-determine-timing-of-apoptotic-response-to-chemotherapy-in-solid-tumors
#17
Emre Demirci, Rafay Ahmed, Meltem Ocak, Joseph Latoche, April Radelet, Nicole DeBlasio, N Scott Mason, Carolyn J Anderson, James M Mountz
PURPOSE: We investigated 2-(5-fluoro-pentyl)-2-methyl-malonic acid ((18)F-ML-10) positron emission tomography (PET) imaging of apoptosis posttherapy to determine optimal timing for predicting chemotherapy response in a mouse head/neck xenograft cancer model. PROCEDURES: BALB/c nude mice (4-8 weeks old) were implanted with UM-SCC-22B tumors. The treatment group received 2 doses of doxorubicin (10 mg/kg, days 0, 2). Small animal (18)F-ML-10 PET/computed tomography was performed before and on days 1, 3, and 7 postchemotherapy...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654306/gene-expression-profile-of-peripheral-blood-mononuclear-cells-in-response-to-intracerebral-hemorrhage
#18
Ming Sang, Xuanbin Wang, Hanyao Zhang, Xiaodong Sun, Xudong Ding, Puqing Wang, Rong Jiao, Huaxian Cheng, Sijun Yang, Guibin Zhang
RNA-sequencing, a powerful tool, yields a comprehensive view of whole transcriptome. Intracerebral hemorrhage (ICH) is a devastating form of stroke. To date, RNA-sequencing analysis of ICH has not been reported. Peripheral blood mononuclear cells (PBMCs) were used as a source of mRNA for gene expression profile analysis in stroke. In this study, we performed transcriptome analyses for PBMCs from four ICH patients and four healthy volunteers on Illumina platform. We identified 4040 significantly differentially expressed genes (DEGs)...
June 27, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28654176/multiple-pseudomonas-species-secrete-exolysin-like-toxins-and-provoke-caspase-1-dependent-macrophage-death
#19
REVIEW
Pauline Basso, Pierre Wallet, Sylvie Elsen, Emmanuelle Soleilhac, Thomas Henry, Eric Faudry, Ina Attrée
Pathogenic bacteria secrete protein toxins that provoke apoptosis or necrosis of eukaryotic cells. Here, we developed a live-imaging method, based on incorporation of a DNA-intercalating dye into membrane-damaged host cells, to study the kinetics of primary bone marrow-derived macrophages (BMDMs) mortality induced by opportunistic pathogen Pseudomonas aeruginosa expressing either Type III Secretion System (T3SS) toxins or the pore-forming toxin, Exolysin (ExlA). We found that ExlA promotes the activation of Caspase-1 and maturation of interleukin-1β...
June 27, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28654064/detection-and-visualization-of-dna-damage-induced-protein-complexes-in-suspension-cell-cultures-using-the-proximity-ligation-assay
#20
Mahnoush Bahjat, Timon A Bloedjes, Amélie van der Veen, Guus de Wilde, Chiel Maas, Jeroen E J Guikema
The DNA damage response orchestrates the repair of DNA lesions that occur spontaneously, are caused by genotoxic stress, or appear in the context of programmed DNA breaks in lymphocytes. The Ataxia-Telangiectasia Mutated kinase (ATM), ATM- and Rad3-Related kinase (ATR) and the catalytic subunit of DNA-dependent Protein Kinase (DNA-PKcs) are among the first that are activated upon induction of DNA damage, and are central regulators of a network that controls DNA repair, apoptosis and cell survival. As part of a tumor-suppressive pathway, ATM and ATR activate p53 through phosphorylation, thereby regulating the transcriptional activity of p53...
June 9, 2017: Journal of Visualized Experiments: JoVE
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