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Angiotensin 2 AND ROS

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https://www.readbyqxmd.com/read/28088732/apelin-13-protects-rat-primary-cortical-glia-neuron-co-culture-against-pentylenetetrazole-induced-toxicity
#1
Taj Pari Kalantaripour, Saeed Esmaeili-Mahani, Vahid Sheibani, Hamid Najafipour, Majid Asadi-Shekaari M
In spite of recent advances in the treatment of epilepsy, up to 35% of people living with the condition do not respond to accessible anti-epileptic drugs (AEDs) and continue to experience regular, devastating and potentially life-threatening seizures. Neuronal death is a significant feature of epilepsy in humans and experimental models. It has been reported that apelin, an endogenous ligand for the angiotensin-1-like receptor (APJ), has anticonvulsive as well as protective effects in some neurodegenerative situations...
January 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28078995/sphingolipids-in-genetic-and-acquired-forms-of-chronic-kidney-diseases
#2
Norishi Ueda
Sphingolipids (SLs) regulate apoptosis, proliferation, and stress response. SLs, including ceramide, glycosphingolipids (glucosylceramide, lactosylceramide, and gangliosides) and sphingosine-1-phosphate (S1P), play a role in the pathogenesis and progression of genetic (lysosomal storage disease, congenital nephrotic syndrome and polycystic kidney disease) and non-genetic forms of chronic kidney diseases (CKDs). SLs metabolism defects promote complications (cardiovascular events, etc.) via oxidant stress in CKDs...
January 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28011270/h2s-inhibits-angiotensin-ii-induced-atrial-kv1-5-upregulation-by-attenuating-nox4-mediated-ros-generation-during-atrial-fibrillation
#3
Guihua Lu, Chenggui Xu, Kaiyu Tang, Juhong Zhang, Qinglang Li, Longyun Peng, Yesong Wang, Zhibin Huang, Xiuren Gao
Our previous study demonstrated that angiotensin II (Ang II) upregulates the expression of Kv1.5, a promising target for atrial fibrillation (AF) therapy, by activating ROS-dependent P-Smad2/3 and P-ERK 1/2. A recent study showed that hydrogen sulfide (H2S) may modulate the effects of angiotensin II (Ang II) by inhibiting the NADPH oxidase 4 (Nox4)-ROS signaling in the heart. The present study aimed to determine whether H2S is involved in the regulation of atrial Kv1.5 via ROS-related mechanisms in AF. Cultured neonatal rat atrial myocytes and a beagle model of AF were used for this study...
December 21, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28010122/lysyl-oxidase-induces-vascular-oxidative-stress-and-contributes-to-arterial-stiffness-and-abnormal-elastin-structure-in-hypertension-role-of-p38mapk
#4
Sonia Martínez-Revelles, Ana Belen Garcia-Redondo, Mª Soledad Avendaño, Saray Varona, Teresa Palao, Mar Orriols, Fernanda R Roque, Ana Fortuño, Rhian M Touyz, Jose Martínez-Gonzalez, Mercedes Salaices, Cristina Rodríguez, Ana María Briones
AIMS: Vascular stiffness, structural elastin abnormalities and increased oxidative stress are hallmarks of hypertension. Lysyl oxidase (LOX) is an elastin cross-linking enzyme that produces H<sub>2</sub>O<sub>2</sub> as by-product. We addressed the interplay between LOX, oxidative stress, vessel stiffness and elastin. RESULTS: Angiotensin II (Ang II)-infused hypertensive mice and spontaneously hypertensive rats (SHR) showed increased vascular LOX expression and stiffness and abnormal elastin structure...
December 23, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27919636/adrenomedullin-and-angiotensin-ii-signaling-pathways-involved-in-the-effects-on-cerebellar-antioxidant-enzymes-activity
#5
Figueira Leticia, Israel Anita
Human adrenomedullin (AM) is a 52-amino acid peptide involved in cardiovascular control. AM has two specific receptors formed by the calcitonin-receptor-like receptor (CRLR) and receptor activity-modifying protein (RAMP) 2 or 3, known as AM1 and AM2 receptors, respectively. In addition, AM has appreciable affinity for the calcitonin gene-1 related peptide receptor (CGRP1), composed of CRLR/RAMP1. In brain, AM and their receptors are expressed in several localized areas, including the cerebellum. AM has been reported as an antioxidant...
January 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/27896943/ang-1-7-protects-cardiomyocytes-against-hg-induced-injuries-through-inhibiting-ros-activated-leptin-p38-mapk-erk1-2-pathways-but-not-leptin-jnk-pathway-in-vitro
#6
Yiyan Lei, Qing Xu, Bo Zeng, Wei Zhang, Yulan Zhen, Yuansheng Zhai, Fei Cheng, Weiyi Mei, Dongdan Zheng, Jianqiang Feng, Jun Lan, Jingfu Chen
AIMS: Angiotensin-(1-7) [Ang-(1-7)], recognized as a new bioactive peptide in renin-angiotensin system (RAS), shows biological and pharmacological properties in diabetic cardiovascular diseases. Leptin induced-p38 MAPK pathway has been reported to contribute to the high glucose (HG)-induced injury. In this study, we demonstrated the mechanism that how Ang-(1-7) can protect from HG-stimulated injuries in H9c2 cells. METHODS: H9c2 cells were treated with 35 mM glucose (HG) for 24 h to establish a model of HG-induced damage...
November 29, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27822383/neuronal-nitric-oxide-synthase-in-hypertension-an-update
#7
REVIEW
Yin Hua Zhang
Hypertension is a prevalent condition worldwide and is the key risk factor for fatal cardiovascular complications, such as stroke, sudden cardiac death and heart failure. Reduced bioavailability of nitric oxide (NO) in the endothelium is an important precursor for impaired vasodilation and hypertension. In the heart, NO deficiency deteriorates the adverse consequences of pressure-overload and causes cardiac hypertrophy, fibrosis and myocardial infarction which lead to fatal heart failure and sudden cardiac death...
2016: Clinical Hypertension
https://www.readbyqxmd.com/read/27807688/angiotensin-ii-induced-early-and-late-inflammatory-responses-through-noxs-and-mapk-pathways
#8
Xi Zhang, Jia Yang, Xinyi Yu, Si Cheng, Hua Gan, Yunfeng Xia
Angiotensin II (Ang II) dysregulation has been determined as cause or an effect of many diseases. The relationship between Ang II and reactive oxygen species (ROS), which are generated by enzymes in the nicotinamide adenine dinucleotide phosphate oxidase (NOX) family, has been the focus of many researchers for years. Inflammation in response to the activities of various NOXs with differing time-dependent characteristics was reported. It is still unclear how these factors interplay over the course of the inflammatory response and how signal transduction through mitogen-activated protein kinase (MAPK) pathways...
November 2, 2016: Inflammation
https://www.readbyqxmd.com/read/27775793/microrna-125b-contributes-to-high-glucose-induced-reactive-oxygen-species-generation-and-apoptosis-in-hk-2-renal-tubular-epithelial-cells-by-targeting-angiotensin-converting-enzyme-2
#9
Y-F Huang, Y Zhang, C-X Liu, J Huang, G-H Ding
OBJECTIVE: Hyperglycemia induces apoptosis of renal tubular epithelial cells and contributes to tubular injury in diabetic nephropathy. Angiotensin-converting enzyme 2 (ACE2) is known to protect against diabetic kidney injury. However, the mechanism for the dysregulation of ACE2 expression in diabetic nephropathy is unclear. MATERIALS AND METHODS: Bioinformatic analysis and luciferase reporter assay were done to identify ACE2-targeting microRNAs. Gain- and loss-of-function experiments were performed to determine the biological roles of the ACE2-targeting microRNAs in high glucose-induced damage to renal tubular epithelial cells...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27775423/lack-of-reactive-oxygen-species-deteriorates-blood-pressure-regulation-in-acute-stress
#10
I Bernátová, P Bališ, R Goga, M Behuliak, J Zicha, I Sekaj
This study investigated the contribution of reactive oxygen species (ROS) to blood pressure regulation in conscious adult male Wistar rats exposed to acute stress. Role of ROS was investigated in rats with temporally impaired principal blood pressure regulation systems using ganglionic blocker pentolinium (P, 5 mg/kg), angiotensin converting enzyme inhibitor captopril (C, 10 mg/kg), nitric oxide synthase inhibitor L-NAME (L, 30 mg/kg) and superoxide dismutase mimeticum tempol (T, 25 mg/kg). Mean arterial pressure (MAP) was measured by the carotid artery catheter and inhibitors were administered intravenously...
October 24, 2016: Physiological Research
https://www.readbyqxmd.com/read/27754054/os-15-02-matrix-metalloproteinase-2-knockout-protects-from-angiotensin-ii-induced-vascular-injury-in-part-via-inhibition-of-egfr-and-erk1-2-activation
#11
Pierre Paradis, Tlili Barhoumi, Muhammad Oneeb Rehman Mian, Julio C Fraulob-Aquino, Asia Rehman, Nourredine Idris-Khodja, Ernesto L Schiffrin
OBJECTIVE: Matrix metalloproteinase 2 (MMP2) is involved in cardiovascular disease. Whether MMP2 plays a role in hypertension and vascular damage is unknown. We hypothesized that Mmp2 knockout will prevent angiotensin (Ang) II-induced hypertension and vascular injury. DESIGN AND METHOD: Mmp2 knockout (Mmp2) and wild-type (WT) mice were infused with Ang II (1000 ng/kg/min, SC) for 14 days. Systolic blood pressure (SBP) was measured by telemetry, and mesenteric artery (MA) endothelial function and vascular remodeling by pressurized myography...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27687768/angiotensin-1-7-abrogates-angiotensin-ii-induced-proliferation-migration-and-inflammation-in-vsmcs-through-inactivation-of-ros-mediated-pi3k-akt-and-mapk-erk-signaling-pathways
#12
Feng Zhang, Xingsheng Ren, Mingxia Zhao, Bing Zhou, Ying Han
The proliferation, migration and inflammation of vascular smooth muscle cells (VSMCs) contribute to the pathogenesis and progression of several cardiovascular diseases such as atherosclerosis and hypertension. Angiotensin (Ang)-(1-7) and Ang II are identified to be involved in regulating cardiovascular activity. The present study is designed to determine the interaction between Ang-(1-7) and Ang II on VSMCs proliferation, migration and inflammation as well as their underlying mechanisms. We found that Ang-(1-7) significantly suppressed the positive effects of Ang II on VSMCs proliferation, migration and inflammation, as well as on induction of the phosphorylation of Akt and ERK1/2 and increase of superoxide anion level and NAD(P)H oxidase activity in VSMCs, whereas Ang-(1-7) alone had no significant effects...
September 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27658784/the-ros-derived-mitochondrial-respirstion-not-from-nadph-oxidase-plays-key-role-in-celastrol-against-angiotensin-ii-mediated-hepg2-cell-proliferation
#13
Xin Liu, Rui-Wei Gao, Miao Li, Chun-Feng Si, Yong-Peng He, Min Wang, Ying Yang, Qing-Yin Zheng, Chao-Yun Wang
Angiotensin II (AngII) is an important factor that promotes the proliferation of cancer cells, whereas celastrol exhibits a significant antitumor activity in various cancer models. Whether celastrol can effectively suppress AngII mediated cell proliferation remains unknown. In this study, we studied the effect of celastrol on AngII-induced HepG2 cell proliferation and evaluated its underlying mechanism. The results revealed that AngII was able to significantly promote HepG2 cell proliferation via up-regulating AngII type 1 (AT1) receptor expression, improving mitochondrial respiratory function, enhancing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, increasing the levels of reactive oxygen species (ROS) and pro-inflammatory cytokines...
November 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27642974/os-15-02-matrix-metalloproteinase-2-knockout-protects-from-angiotensin-ii-induced-vascular-injury-in-part-via-inhibition-of-egfr-and-erk1-2-activation
#14
Pierre Paradis, Tlili Barhoumi, Muhammad Oneeb Rehman Mian, Julio C Fraulob-Aquino, Asia Rehman, Nourredine Idris-Khodja, Ernesto L Schiffrin
OBJECTIVE: Matrix metalloproteinase 2 (MMP2) is involved in cardiovascular disease. Whether MMP2 plays a role in hypertension and vascular damage is unknown. We hypothesized that Mmp2 knockout will prevent angiotensin (Ang) II-induced hypertension and vascular injury. DESIGN AND METHOD: Mmp2 knockout (Mmp2) and wild-type (WT) mice were infused with Ang II (1000 ng/kg/min, SC) for 14 days. Systolic blood pressure (SBP) was measured by telemetry, and mesenteric artery (MA) endothelial function and vascular remodeling by pressurized myography...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27570480/gamma-secretase-inhibitor-prevents-proliferation-and-migration-of-ductus-arteriosus-smooth-muscle-cells-through-the-notch3-hes1-2-5-pathway
#15
Jiunn-Ren Wu, Jwu-Lai Yeh, Shu-Fen Liou, Zen-Kong Dai, Bin-Nan Wu, Jong-Hau Hsu
Patent ductus arteriosus (PDA) can cause morbidity and mortality in neonates. Vascular remodeling, characterized by proliferation and migration of smooth muscle cells (SMCs), is an essential process for postnatal DA closure. Notch signaling is an important mediator of vascular remodelling but its role in DA is unkonwn. We investigated the effects and underlying mechanisms of γ-secretase inhibitor DAPT, a Notch signaling inhibitor on angiotensin II (Ang II)-induced proliferation and migration of DASMCs. Proliferation and migration of DASMCs cultured from neonatal Wistar rats were induced by Ang II, with or without DAPT pre-treatment...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27565029/mir-106a-promotes-cardiac-hypertrophy-by-targeting-mitofusin-2
#16
Xiaoxiang Guan, Lu Wang, Zhenhong Liu, Xiaofei Guo, Ying Lu, Yanli Peng, Tianhua Liu, Baofeng Yang, Hongli Shan, Yong Zhang, Chaoqian Xu
Pathological cardiac hypertrophy is a main factor leading to heart failure and associated sudden death. Improved understanding of the underlying molecular mechanisms should aid better treatment of the disease. This study aimed to test our hypothesis that a microRNA miR-106a played an important role in the development of cardiac hypertrophy through targeting mitofusin 2 (Mfn2), a mitochondrial fusion protein known to be critical in regulating cardiac function. miR-106a was robustly upregulated in hypertrophied myocardium both in vivo and in vitro...
August 23, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27525285/oxidative-stress-in-diabetic-nephropathy-with-early-chronic-kidney-disease
#17
REVIEW
Alejandra Guillermina Miranda-Díaz, Leonardo Pazarín-Villaseñor, Francisco Gerardo Yanowsky-Escatell, Jorge Andrade-Sierra
The increase in the prevalence of diabetes mellitus (DM) and the secondary kidney damage produces diabetic nephropathy (DN). Early nephropathy is defined as the presence of microalbuminuria (30-300 mg/day), including normal glomerular filtration rate (GFR) or a mildly decreased GFR (60-89 mL/min/1.73 m(2)), with or without overt nephropathy. The earliest change caused by DN is hyperfiltration with proteinuria. The acceptable excretion rate of albumin in urine is <30 mg/day. Albuminuria represents the excretion of >300 mg/day...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27506987/blackberry-raspberry-and-black-raspberry-polyphenol-extracts-attenuate-angiotensin-ii-induced-senescence-in-vascular-smooth-muscle-cells
#18
Rafaela G Feresin, Jingwen Huang, DawnKylee S Klarich, Yitong Zhao, Shirin Pourafshar, Bahram H Arjmandi, Gloria Salazar
Activation of angiotensin II (Ang II) signaling during aging increases reactive oxygen species (ROS) leading to vascular senescence, a process linked to the onset and progression of cardiovascular diseases (CVD). Consumption of fruits and vegetables, particularly berries, is associated with decreased incidence of CVD, which has mainly been attributed to the polyphenol content of these foods. Thus, the objective of this study was to investigate the role of blackberry (BL), raspberry (RB), and black raspberry (BRB) polyphenol extracts in attenuating Ang II-induced senescence in vascular smooth muscle cells (VSMCs) and to determine the molecular mechanisms involved...
October 12, 2016: Food & Function
https://www.readbyqxmd.com/read/27492718/epigallocatechin-3-gallate-inhibits-angiotensin-ii-induced-c-reactive-protein-generation-through-interfering-with-the-at1-ros-erk1-2-signaling-pathway-in-hepatocytes
#19
Jingjing Zhao, Juntian Liu, Xiaoming Pang, Xiaolu Zhang, Shuyue Wang, Di Wu
Inflammation plays a key role in many chronic diseases such as cardiovascular diseases and liver diseases. As a representative inflammatory molecule, C-reactive protein (CRP) is mainly produced in the liver. Hepatic CRP plays a direct role in the inflammatory hepatic diseases and in development of atherosclerosis when entering into the blood circulation. In the present study, we observed the effect of epigallocatechin-3-gallate (EGCG) on Ang II-induced CRP generation in hepatocytes and the molecular mechanism...
November 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27430410/antioxidant-effect-of-angiotensin-1%C3%A2-7-in-the-protection-of-pancreatic-%C3%AE-cell-function
#20
Fen Zhang, Chang Liu, Lei Wang, Xi Cao, Ying Ying Wang, Jin Kui Yang
It is well known that the local renin-angiotensin system (RAS) is activated in the diabetic state, which results in an increase in the level of oxidative stress injury to pancreatic β cells. The angiotensin‑converting enzyme 2 (ACE2)/angiotensin (1‑7) [Ang (1‑7)]/Mas axis is a negative regulator of the classical renin‑angiotensin system. In order to investigate the antioxidant effect of Ang (1‑7) on pancreatic β cells, INS‑1 cells were cultured and oxidative stress was induced by treatment with H2O2...
September 2016: Molecular Medicine Reports
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