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Orbital inflammation

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https://www.readbyqxmd.com/read/27922461/ipsilateral-ophthalmic-and-cerebral-infarctions-after-cosmetic-polylactic-acid-injection-into-the-forehead
#1
Ashwinee Ragam, Steven A Agemy, Sarita B Dave, Azita S Khorsandi, Rudrani Banik
A 55-year-old woman developed no light perception vision in her right eye 5 days after an injection of polylactic acid cosmetic filler into her right forehead. Diffuse corneal edema and anterior chamber inflammation prohibited any view to the posterior segment to identify the cause of her profound vision loss. MRI of the orbits with diffusion-weighted imaging showed hyperintensity of the right optic nerve with signal reduction on apparent diffusion coefficient mapping, consistent with ischemia. Our patient also was found to have acute infarctions in the distribution of the right anterior cerebral artery on MRI of the brain despite having no permanent focal neurologic deficits aside from vision loss...
December 2, 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27914713/true-abscess-formation-is-rare-in-bacterial-orbital-cellulitis-consequences-for-treatment
#2
Eline G Van der Veer, Nicolien A van der Poel, Maartje M L de Win, Roel J Kloos, Peerooz Saeed, Maarten P Mourits
BACKGROUND: Pre- or retroseptal bacterial orbital cellulitis (pOC/rOC) is not an uncommon orbital disease. Treatment consists of antibiotics with or without surgical drainage. Several questions regarding course, complications and outcome of treatment are unanswered and the indication for surgery is not well defined. The aim of this study is to: 1. describe the outcome of orbital cellulitis (OC) in a large cohort, 2. assess the significance of Chandler's classification, 3. assess the incidence of abscess formation in OC, and 4...
November 24, 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27911423/-core-principles-of-treatment-of-corneal-damage-in-patients-with-thyroid-eye-disease
#3
Ya O Grusha, D S Ismailova, L V Sherstneva
AIM: To develop a therapeutic approach and to estimate the efficiency of complex treatment of corneal damage in patients with thyroid eye disease (TED). MATERIAL AND METHODS: The study enrolled 44 patients (52 eyes) divided into 2 groups depending on the severity of corneal damage. Treatment of those with severe involvement included pathogenetic measures (pulse steroid therapy and/or radiation therapy) and surgery (orbital decompression, eyelid and corneal surgery)...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27896542/immunomodulatory-effects-of-adjuvants-cpg-mpla-and-bcg-on-the-derp2-induced-acute-asthma-at-early-life-in-an-animal-model-of-balb-c-mice
#4
V Mohammadi-Shahrokhi, A Rezaei, A Andalib, A Rahnama, A Jafarzadeh, N Eskandari
The Th1- and Treg cell-related immune responses play key roles in the modulation of Th2 cell-related allergic disorders. The aim was to evaluate the effects of CPG, MPLA, and BCG on the number of Th1-, Th2-, and Treg cell-related parameters in an animal model of asthma. BALB/c mice were divided into five groups and immunized subcutaneously (SC) on days 1, 15, and 22 with allergen Derp2. Three groups of mice were pretreated SC on days 0, 14, and 21 with CPG, CPG + MPLA, or CPG + BCG. All mice were then challenged intranasally with Derp2 on days 28-37...
November 28, 2016: Inflammation
https://www.readbyqxmd.com/read/27879620/recurrent-orbital-inflammation-mimicking-orbital-cellulitis-associated-with-orbitopalpebral-venous-lymphatic-malformation
#5
Alicia Galindo-Ferreiro, Hind M Alkatan, Sahar M ElKhamary, Saif AlDosairi, A Augusto V Cruz
An 8-year-old boy initially presented with an orbitopalpebral mass diagnosed clinically and radiologically as a low-flow diffuse venous lymphatic malformation involving the left upper eyelid and orbit. Over 8 months of follow up, he had 2 acute episodes of severe orbital inflammation that warranted hospitalization and treatment with intravenous antibiotic, steroids and surgical debulking. After a third surgical excision, the lesion remained clinically stable.
November 22, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27843275/current-trends-in-treatment-outcomes-of-orbital-cellulitis-in-a-tertiary-hospital-in-southern-nigeria
#6
Odarosa M Uhumwangho, Dumebi H Kayoma
BACKGROUND: Orbital cellulitis refers to the inflammation or infection of the soft tissues of the orbit located behind the orbital septum. AIM: To determine the current trends in the outcomes following the management of orbital cellulitis in a tertiary hospital in Southern Nigeria. PATIENTS AND METHODS: A retrospective review of medical records of patients with orbital cellulitis from January 2008 to December 2014 was conducted. The age, sex, duration of symptoms, predisposing factors, clinical findings, laboratory/radiological investigations, treatment provided, complications, and follow-up were recorded...
July 2016: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/27828922/idiopathic-unilateral-enlargement-of-the-extraocular-muscles-in-an-infant
#7
Yasha Modi, Benjamin Erickson, Isha Ranadive, Joshua Pasol, Sara Wester, Kara Cavuoto
A 6-month-old boy presented with a unilateral motility deficit of the right eye in all fields of gaze. Neuroimaging revealed unilateral enlargement of the medial, lateral, and inferior rectus muscles with sparing of the tendons. An evaluation for thyroid eye disease, idiopathic orbital inflammation, myositis, inflammatory and neoplastic infiltration of the muscle, vascular anomalies, and metastatic neuroblastoma was unrevealing. Biopsy of the muscle revealed normal architecture with an absence of inflammation, infiltration, or fibrosis...
November 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27828782/pheochromocytoma-multisystem-crisis-triggered-by-glucocorticoid-administration-and-aggravated-by-citrate-dialysis
#8
Chuen Jye Yeoh, Shin Yi Ng, Brian K P Goh
Pheochromocytoma multisystem crisis is the most severe presentation of pheochromocytoma. We report on a 68-year-old survivor of pheochromocytoma multisystem crisis, whose clinical course was triggered inadvertently by a short innocuous course of oral dexamethasone to suppress inflammation and swelling after a left orbital floor fracture repair. He presented first with severe epigastric pain and headache, and subsequently experienced insults to neurological, cardiac, respiratory, hepatobiliary, renal, and immune system in his prolonged intensive care unit stay...
November 8, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/27799649/sclerosing-orbital-inflammation-caused-by-leishmania-braziliensis
#9
Antonio Augusto V Cruz, Eliza V C Alves-Ferreira, Gherusa Milbratz-Moré, Fernando Chahud, Patricia C Ruy, Maria Irma Seixas Duarte, Angela Kaysel Cruz
Orbital biopsy of nonspecific orbital inflammation, commonly referred to as "orbital pseudotumor," typically shows a combination of polyclonal lymphocytes, plasmocytes, leukocytes, macrophages, and variable degrees of collagen deposition. Herein, we report a patient with a positive history of mucocutaneous leishmaniasis who presented with an orbital mass with a histological profile of idiopathic orbital inflammation. Immunohistochemical and molecular analysis of the orbital specimens demonstrated that the orbital inflammation was associated with the presence of antigens of Leishmania braziliensis and DNA from the parasite...
October 31, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27768642/retrobulbar-injection-of-amphotericin-b-for-orbital-mucormycosis
#10
Kristin E Hirabayashi, Evan Kalin-Hajdu, Frank L Brodie, Robert C Kersten, Matthew S Russell, M Reza Vagefi
A 68-year-old immunocompromised man with rhino-orbital-cerebral mucormycosis was treated with retrobulbar injections of amphotericin B deoxycholate in conjunction with intravenous antifungals and endoscopic sinus debridement. Transient episodes of orbital inflammation were noted after retrobulbar injections, but progression of orbital infection was halted and visual acuity restored with eventual hospital discharge. To the authors' knowledge, clearance of orbital mucormycosis with retrobulbar amphotericin B injections has not been previously reported...
October 20, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27761242/idiopathic-sclerosing-orbital-inflammation-mimicking-a-malignant-spindle-cell-tumor-in-a-dog
#11
Nina Marie Rzechorzek, Colin Smith, Tobias Schwarz, Tiziana Liuti, Richard Elders, Samantha Woods, Jessica Lawrence, Katia Marioni-Henry
A dog presented with a retrobulbar mass, diagnosed histopathologically as malignant spindle cell neoplasia. Emergence of analogous findings in the contralateral orbit prompted extended immunohistochemistry of the original mass and reassignment to idiopathic sclerosing orbital inflammation. Early incisional biopsy with extended immunohistochemical analysis should be considered for canine orbital tumors.
October 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/27755058/fragmented-sleep-enhances-postoperative-neuroinflammation-but-not-cognitive-dysfunction
#12
Susana Vacas, Vincent Degos, Mervyn Maze
BACKGROUND: Sleep is integral to biologic function, and sleep disruption can result in both physiological and psychologic dysfunction including cognitive decline. Surgery activates the innate immune system, inducing neuroinflammatory changes that interfere with cognition. Because surgical patients with sleep disorders have an increased likelihood of exhibiting postoperative delirium, an acute form of cognitive decline, we investigated the contribution of perioperative sleep fragmentation (SF) to the neuroinflammatory and cognitive responses of surgery...
October 11, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27726522/the-spectrum-of-uveitis-in-southern-vietnam
#13
Myhanh Nguyen, Jay Siak, Soon-Phaik Chee, Vo Quang Hong Diem
PURPOSE: To describe the pattern of uveitis among Vietnamese at two eye hospitals in Southern Vietnam. METHODS: We retrospectively reviewed the charts of 212 consecutive uveitis cases that presented to two eye hospitals in Ho Chi Minh City, Vietnam, from July 2011 to February 2015. The patients were identified from a database maintained by the hospitals. Patients with keratitis, episcleritis, orbital inflammation, post-surgical endophthalmitis, traumatic iritis, and corneal graft rejection were excluded...
October 11, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27688285/igg4-related-intraocular-inflammation-masquerading-as-ciliary-body-melanoma-in-a-young-girl
#14
Dipankar Das, Panna Deka, Geeta Verma, Ganesh Chandra Kuri, Harsha Bhattacharjee, Gayatri Bharali, Divya Pandey, Akanksha Koul, Bidisha Das, Apurba Deka
Immunoglobulin G4 (IgG4-related diseases) affects various tissues and organs of the human body. Orbital, adnexal, and scleral inflammations were already reported in the medical literature. To the best of our knowledge, we report the first case of intraocular IgG4-associated inflammatory mass in the ciliary body mimicking as a melanoma in a 23-year-old female from Northeast India. Characteristic histopathology, immunohistochemistry in the tissue, protein chemistry, and raised serum IgG4 were supportive for the diagnosis...
August 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27662569/systemic-vasculitis-and-the-eye
#15
Ilknur Tugal-Tutkun
PURPOSE OF REVIEW: The primary systemic vasculitides represent a spectrum of rare but life-threatening conditions that may also affect the eye in various forms. This article reviews recently published data on ocular manifestations of systemic vasculitis. RECENT FINDINGS: Early diagnosis and timely treatment has led to better visual outcomes in giant cell arteritis (GCA). Gene expression from orbital tissues could distinguish granulomatosis with polyangiitis (GPA) from sarcoidosis and Graves disease, but not from idiopathic orbital inflammation...
January 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27649521/lymphoma-and-inflammation-in-the-orbit-diagnostic-performance-with-diffusion-weighted-imaging-and-dynamic-contrast-enhanced-mri
#16
Bo Sun, Liyuan Song, Xinyan Wang, Jing Li, Junfang Xian, Feifei Wang, Pan Tan
PURPOSE: To investigate the diagnostic performance of diffusion-weighted imaging (DWI), dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), and the combination of both in the differential diagnosis of lymphoma and inflammation in the orbit. MATERIALS AND METHODS: This retrospective study was approved by the Institutional Review Board and the informed consent requirement was waived. A total of 53 patients underwent preoperative 3T MRI. Parameters of DWI and DCE MRI were evaluated in these 30 patients with orbital lymphoma and 23 patients with orbital inflammation...
September 20, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27631497/cd40-expression-in-fibrocytes-is-induced-by-tsh-potential-synergistic-immune-activation
#17
Tünde Mester, Nupur Raychaudhuri, Erin F Gillespie, Hong Chen, Terry J Smith, Raymond S Douglas
CONTEXT: Fibrocytes appear to participate in inflammation and tissue remodeling in patients with thyroid-associated ophthalmopathy (TAO). These patients have increased frequencies of circulating TSH receptor (TSHR)- and CD40-positive fibrocytes, suggesting TSHR and CD40 may play roles in proinflammatory cytokine production, which ultimately leads to orbital inflammation and tissue remodeling. OBJECTIVE: To investigate the potential interactions between the TSHR and CD40 signaling pathways and their roles in IL-6 and TNF-α production...
2016: PloS One
https://www.readbyqxmd.com/read/27610652/hypoxia-dependent-hif-1-activation-impacts-on-tissue-remodeling-in-graves-ophthalmopathy-implications-for-smoking
#18
Gina-Eva Görtz, Mareike Horstmann, Barbara Aniol, Buena Delos Reyes, Joachim Fandrey, Anja Eckstein, Utta Berchner-Pfannschmidt
CONTEXT: In Graves' ophthalmopathy (GO) inflammation with tissue expansion in a closed compartment like the bony orbit and smoking may cause tissue hypoxia. OBJECTIVES: In this study we investigated whether Hypoxia-inducible factor-1 (HIF-1) action impacts on tissue remodeling in GO with the aim to identify possible new therapeutic targets. DESIGN/SETTING/PARTICIPANTS: Orbital fibroblast (OF) were derived from GO patients and control persons (Ctrl)...
September 9, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27580762/igg4-related-disease-with-cavernous-sinus-and-intra-orbital-lesions-diagnosed-by-nasal-mucosa-biopsy
#19
Ruka Nakata, Shunsuke Yoshimura, Masakatsu Motomura, Akira Tsujino, Tomayoshi Hayashi, Minoru Hara
IgG4-related disease is a systemic disease characterized by lesions with IgG4 positive plasma cell infiltration in the involved organs and a raised serum IgG4 level. We report a patient of 70-year-old male presented orbital inflammation of IgG4-related disease. The patient developed right eye pain, double vision, and reduced eye sight. MRI image revealed mild right ocular proptosis and swelling of right carvenous sinus, bilateral intraorbital extraocular muscles and right optic nerve. Right optic nerve showed ring-like enhancement...
September 29, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27557733/chronic-undiagnosed-orbital-inflammation-due-to-factitious-disorder-a-think-different-paradigm
#20
He Jack Li, Konstantinos T Tsaousis, Ashlie Bernhisel, Nicholas Reiter, Jun Jia Guan, Nick Mamalis, Bhupendra Ck Patel
No abstract text is available yet for this article.
August 25, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
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