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Orbital inflammation

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https://www.readbyqxmd.com/read/28328595/hemorrhage-and-infarction-of-the-conjunctiva-and-orbit-in-essential-thrombocythemia
#1
Jaehoon Na, Soo Youn Choi, Sehyun Baek, Hwa Lee
An 82-year-old woman who had a history of essential thrombocythemia presented with ocular pain, bleeding, and decreased visual acuity of the left eye. Orbital computed tomography revealed a relatively well-defined homogenous mass-like lesion in the left subconjunctival and intraconal space. Conjunctival biopsy showed acute inflammation with necrosis, vascular ectasia with thrombosis and hemorrhage. After the treatment with hydroxyurea and anagrelide, her symptom and lesion were markedly improved. Hematologic disorders like essential thrombocythemia should be considered in patients with severe spontaneous bleeding around the eye...
March 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28328558/dacryoadenitis-as-the-initial-presentation-of-a-natural-killer-t-cell-lymphoma
#2
Juan C Jiménez-Pérez, Frederick A Jakobiec, Fouad R Zakka, Michael K Yoon
Primary orbital natural killer T-cell lymphoma (NKTCL) is a rare condition with only a few published cases in the literature. Over 1 month, an 81-year-old man developed progressive left periocular inflammation unresponsive to treatment. Clinical examination and imaging studies demonstrated a left lacrimal gland enlargement. Bilateral anterior uveitis and erythematous nontender cutaneous lesions were also found. Biopsies of the skin and lacrimal gland on the back revealed histopathologic and immunohistochemical findings confirming Epstein-Barr virus-positive NKTCL...
March 21, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28306365/ulcerative-granuloma-of-the-eyelid-as-the-initial-manifestation-of-granulomatosis-with-polyangiitis-wegener-s-granulomatosis-a-case-report
#3
Helena Brosa Morros, Olaia Subirà, Montse Gomà Gàllego, Maria José Paúles Villar, Ferran Mascaró Zamora, Maravillas Abia Serrano
A 56-year-old-man presented a 2-month history of chalazion in the eyelids without response to treatment and with an inconclusive biopsy. Laboratory results confirmed the presence of Enterobacter cloacae and Streptococcus gordonii infection. Despite appropriate intravenous antibiotic treatment, clinical worsening was observed. Radical surgical excision and total tarsorrhaphy were performed. Following treatment, the patient was asymptomatic for 6 weeks until he developed acute renal failure, generalised arthralgia, acute hypertensive anterior uveitis, and dacryoadenitis...
March 17, 2017: Orbit
https://www.readbyqxmd.com/read/28295009/-refractory-form-of-orbital-granulomatosis-with-polyangiitis-a-clinical-and-morphological-study
#4
E A Kogan, Ya O Grusha, D S Ismailova, P I Novikov, Yu V Abramova, A D Meshkov, E F Rizopulu
Orbital granulomatosis with polyangiitis (Wegener's granulomatosis, GPA), which is characterized by granulomatous inflammation with small-vessel vasculitis, can develop in local and generalized forms of the disease. The introduction of current immunosuppressive therapy regimens has improved the prognosis of the disease; however, there are immunosuppressive treatment-refractory forms of GPA, the morphology of which has been inadequately investigated. The paper describes a clinical case of refractory GPA involving the orbit, as evidenced by histological and immunohistochemical examinations...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28294507/exophthalmos-due-to-sterile-neutrophilic-dermatosis-in-a-dog
#5
Emily K Sharpe, Jessica M Meekins, Mary Bagladi-Swanson, Amy J Rankin
An 8-year-old castrated male Bichon Frise was presented to the Kansas State University Veterinary Health Center for evaluation of unilateral right-sided exophthalmos, suspected secondary to a retrobulbar abscess. The dog had acutely developed right-sided periorbital swelling, exophthalmos with pain on retropulsion, as well as multiple cutaneous exudative plaques on the feet and tail base. On ophthalmic examination, the dog also exhibited mild left-sided exophthalmos with decreased, nonpainful retropulsion. Orbital ultrasound and CT were performed to evaluate the extent of bilateral orbital disease...
March 14, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28275599/ocular-surface-squamous-neoplasia-associated-with-atopic-keratoconjunctivitis
#6
Ankit Shah, Edgar M Espana, Arun D Singh
PURPOSE: To describe 2 cases of invasive squamous cell carcinoma that originated in the setting of severe atopic keratoconjunctivitis (AKC). METHODS: Case one involved a 73-year-old male with atopic eczema and severe AKC who developed a limbal lesion suspicious for ocular surface squamous neoplasia (OSSN). Slit-lamp examination was significant for a new sessile lesion in the temporal limbal region of the left eye. The lesion was treated with excisional biopsy and cryotherapy...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28254446/necrotic-intraocular-retinoblastoma-associated-with-orbital-cellulitis
#7
Hilal Nalci, Kaan Gündüz, Esra Erden
Orbital cellulitis associated with retinoblastoma is uncommon and is characterised by non-infectious inflammation of the periorbital structures. The underlying mechanism is thought to be necrosis of the intraocular tumor leading to intraocular and periorbital inflammation. We report two retinoblastoma patients who presented with an orbital cellulitis-like picture. and discuss clinical characteristics, histopathologic features, and treatment.
February 27, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28243891/igg4-related-disease-presenting-as-panuveitis-without-scleral-involvement
#8
REVIEW
Kinda Najem, Larissa Derzko-Dzulynsky, Edward A Margolin
BACKGROUND: The following case emphasizes the importance of including IgG4-related disease (RD) in the differential diagnosis of intraocular inflammation and multiple cranial nerve palsies. RESULTS: A 33-year-old man, with a history of idiopathic bilateral panuveitis, presented with a new right pupillary-sparing partial third nerve palsy, which spontaneously resolved in 2 weeks, but was followed 1 month later, by a right sixth nerve palsy, which also resolved within a few weeks...
December 2017: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/28235631/clinicopathologic-features-of-peripheral-nerve-sheath-tumors-involving-the-eye-and-ocular-adnexa
#9
Mingjuan L Zhang, Maria J Suarez, Thomas M Bosley, Fausto J Rodriguez
Peripheral nerve sheath tumors (PNSTs) are known to occur in the orbit and comprise 4% of all orbital tumors, but have not been well-studied in contemporary literature. Ninety specimens involving the eye and ocular adnexa (1979-2015) from 67 patients were studied. The mean age was 32.5years. Locations included orbit (58.9%), eyelid (60.0%) and other ocular adnexa. A large majority of specimens were neurofibromas (70.0%), followed by schwannomas (11.1%), neuromas (11.1%), granular cell tumors (n=4), nerve sheath myxomas (n=2), and malignant peripheral nerve sheath tumor (n=1)...
February 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28226381/recurrent-orbital-inflammation-due-to-fibrous-dysplasia
#10
Katarzna Malec, Jagoda Miszczyk, Pawel Brzewski, Pawel Dobosz, Olga Mielczarek
No abstract text is available yet for this article.
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28185649/treatment-by-rituximab-on-six-grave-s-ophthalmopathies-resistant-to-corticosteroids
#11
Flavien Précausta, Sophie Arsène, Peggy Renoult-Pierre, Boris Laure, Lise Crinière, Pierre-Jean Pisella
OBJECTIVES: Graves' ophthalmopathy occurs in 50% of Graves' disease cases. Treatment is based on smoking cessation, and control of the euthyroidism and ocular repercussions associated with the disease. The active orbital forms are treated with glucocorticoids. Non-validated therapies have also been recently tested. Rituximab has been effectively used several times to treat corticosteroid-resistant Graves' ophthalmopathy associated with an optic neuropathy, but its use could be proposed only in inflammatory ophthalmopathies after failure of the corticosteroids...
February 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/28146368/roles-of-il-6-in-ocular-inflammation-a-review
#12
Hassan Ghasemi
PURPOSE: This review represents the current in vitro, in vivo animal and human researches on the roles of IL-6 in inflammatory ocular disorders. Data sources were literature reviewed using PubMed, Medline, and ISI Databases (since 1981 to late 2016). Search items included interleukine-6 (IL-6); chemokine; cytokine, alone or in combination with serum, aqueous, vitreous, eye, ocular, ophthalmic, and review. RESULTS: IL-6 is found to be involved in ocular inflammation...
February 1, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28122678/tumid-lupus-an-unexpected-diagnosis-for-the-otolaryngologist
#13
Gina D Jefferson, Vinay K Aakalu, Marylee Braniecki
Tumid lupus is an uncommon variant of lupus erythematosus. Patients present with subcutaneous lesions. Ophthalmic literature reports disease manifestation as orbital inflammation. Autoimmune serology is often negative. Without a high index of suspicion, the diagnosis is easily overlooked delaying treatment. Tumid lupus is not significantly discussed in the Otolaryngologic literature. Here we present a Case Report of a male who initially presented to Ophthalmology with unilateral orbital complaint of eyelid puffiness...
January 17, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28121477/tear-trough-rejuvenation-a-safety-evaluation-of-the-treatment-by-a-semi-cross-linked-hyaluronic-acid-filler
#14
Marouen Berguiga, Olivier Galatoire
The aim of this study is to describe the experience of 33 physicians, dermatologists and surgeons, with the use of a semi-cross-linked hyaluronic acid (HA) gel as a tear trough deformity filler within one month following injection, and to assess patient satisfaction with the procedure. This study is a case series conducted between February 2012 and December 2012 with the use of semi-cross-linked HA to correct tear trough deformity. The filler was administered in the preperiosteal tissues. The study involved case note review and a patient satisfaction survey...
February 2017: Orbit
https://www.readbyqxmd.com/read/28118197/antronasal-polyp-extending-to-orbital-fossa
#15
Hanifi Bayaroğullari, Gülen Burakgazi, Şemsettin Okuyucu
Sinonasal infections and nasal polyps can be taken as 2 components of a disease. Polyps due to chronic inflammations of nasal cavity and sinuses are not rare. They may present with various clinical signs and symptoms, while the secondary complications may cause serious problems. They are most commonly treated medically, although surgery is the therapy of choice in some conditions. The complications can be listed as mucocele formation, orbital inflammation, intracranial extension by erosion of the boney structures...
January 23, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28087387/orbital-fibroblasts-of-graves-orbitopathy-stimulated-with-proinflammatory-cytokines-promote-b-cell-survival-by-secreting-baff
#16
Fen Tang, Xiaoqing Chen, Yuxiang Mao, Shangtao Wan, Siming Ai, Huasheng Yang, Guangming Liu, Yusha Zou, Miaoli Lin, Liang Dan
The success of rituximab for the treatment of active Graves' orbitopathy (GO) suggests that B cells play a critical role in intraorbital inflammation. B cell activating factor (BAFF) and its homolog a proliferation-inducing ligand (APRIL) are critical for B cell survival. However, the contribution of BAFF/APRIL to GO remains unclear. We sought to determine the role of BAFF/APRIL in the orbits of GO, and found that BAFF was markedly upregulated, while APRIL was not. Additionally, cultured GO orbital fibroblasts (GO-OFs)(2) expressing BAFF were induced to produce a large amount of BAFF...
January 10, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28074859/identifying-a-gene-expression-signature-of-cluster-headache-in-blood
#17
Else Eising, Nadine Pelzer, Lisanne S Vijfhuizen, Boukje de Vries, Michel D Ferrari, Peter A C 't Hoen, Gisela M Terwindt, Arn M J M van den Maagdenberg
Cluster headache is a relatively rare headache disorder, typically characterized by multiple daily, short-lasting attacks of excruciating, unilateral (peri-)orbital or temporal pain associated with autonomic symptoms and restlessness. To better understand the pathophysiology of cluster headache, we used RNA sequencing to identify differentially expressed genes and pathways in whole blood of patients with episodic (n = 19) or chronic (n = 20) cluster headache in comparison with headache-free controls (n = 20)...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28041873/il-33-enhances-macrophage-m2-polarization-and-protects-mice-from-cvb3-induced-viral-myocarditis
#18
Chao Wang, Chunsheng Dong, Sidong Xiong
Viral myocarditis is the inflammation caused by myocardial virus infection, and the coxsackievirus group B3 virus (CVB3) is the most common pathogen. An efficient therapeutic agent against viral myocarditis is currently unavailable. IL-33, a new member of the IL-1 cytokine superfamily, exhibits potential immunotherapeutic effect against inflammatory and autoimmune diseases. However, the functional role of IL-33 in viral myocarditis has not been investigated. To examine the therapeutic role of IL-33 in viral myocarditis, an IL-33 overexpression plasmid (pDisplay-IL-33) and IL-33 knockdown plasmid (pLL3...
February 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27922461/ipsilateral-ophthalmic-and-cerebral-infarctions-after-cosmetic-polylactic-acid-injection-into-the-forehead
#19
Ashwinee Ragam, Steven A Agemy, Sarita B Dave, Azita S Khorsandi, Rudrani Banik
A 55-year-old woman developed no light perception vision in her right eye 5 days after an injection of polylactic acid cosmetic filler into her right forehead. Diffuse corneal edema and anterior chamber inflammation prohibited any view to the posterior segment to identify the cause of her profound vision loss. MRI of the orbits with diffusion-weighted imaging showed hyperintensity of the right optic nerve with signal reduction on apparent diffusion coefficient mapping, consistent with ischemia. Our patient also was found to have acute infarctions in the distribution of the right anterior cerebral artery on MRI of the brain despite having no permanent focal neurologic deficits aside from vision loss...
March 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27914713/true-abscess-formation-is-rare-in-bacterial-orbital-cellulitis-consequences-for-treatment
#20
Eline G Van der Veer, Nicolien A van der Poel, Maartje M L de Win, Roel J Kloos, Peerooz Saeed, Maarten P Mourits
BACKGROUND: Pre- or retroseptal bacterial orbital cellulitis (pOC/rOC) is not an uncommon orbital disease. Treatment consists of antibiotics with or without surgical drainage. Several questions regarding course, complications and outcome of treatment are unanswered and the indication for surgery is not well defined. The aim of this study is to: 1. describe the outcome of orbital cellulitis (OC) in a large cohort, 2. assess the significance of Chandler's classification, 3. assess the incidence of abscess formation in OC, and 4...
November 24, 2016: American Journal of Otolaryngology
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