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Orbital inflammation

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https://www.readbyqxmd.com/read/29661986/maxillary-sinus-mucocele-with-orbital-complications
#1
Nicola Lombardo, Pierpaolo Ferrise, Giovanna Lucia Piazzetta, Donatella Bruzzichessi, Domenico Testa, Pasquale Viola, Corrado Pelaia, Gaetano Motta
INTRODUCTION: Maxillary sinus mucocele is an unusual clinic entity (incidence of 3-10%), represented by mucous secretion lined by respiratory stratified pavemented epithelium and its origin is mainly secondary to infections, inflammations, surgery, trauma or neoplasia. CASE REPORT: We present a case of maxillary sinus mucocele. Subject of the study is a 74 aged patient referring positive anamnesis for nasal cavity surgery. His symptoms appeared six months ago and he complainted vertical ocular diplopia and ocular tension sensation, without rhinologic complaints...
April 9, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29649988/the-function-and-morphology-of-meibomian-glands-in-patients-with-thyroid-eye-disease-a-preliminary-study
#2
Chia-Yu Wang, Ren-Wen Ho, Po-Chiung Fang, Hun-Ju Yu, Chun-Chih Chien, Chang-Chun Hsiao, Ming-Tse Kuo
BACKGROUND: To investigate function and morphology of the meibomian gland (MG) in patients with thyroid eye disease (TED). METHODS: In this prospective case series study, patients with unilateral or bilateral TED were consecutively enrolled. The diagnosis of TED was based on the typical orbital findings and/or radiographic evidence. The disease activity of TED was classified according to the clinical activity score (CAS). Degrees of lagophthalmos and exophthalmos, blinking rates, and results of the Schirmer test 1 were also recorded...
April 12, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29601153/lacrimal-sac-exposure-and-a-superior-lateral-anterior-pedicle-flap-to-improve-outcomes-of-draf-type-ii-and-iii-procedures
#3
Kazuhiro Omura, Kazuhiro Nomura, Satoshi Aoki, Yukio Katori, Yasuhiro Tanaka, Nobuyoshi Otori
BACKGROUND: Although the efficacy of Draf type II and III procedures for frontal sinus diseases is well recognized, a certain amount of postoperative stenosis of the frontal neo-ostium occurs. Exposed bone induces inflammation and leads to osteoneogenesis. To prevent stenosis, we developed a surgical technique designed to minimize bone exposure while maximizing the frontal neo-ostium area created with Draf type II and III procedures. We fully exposed the lacrimal sac and used a superior lateral anterior pedicle flap to cover the exposed bone during the Draf procedure...
March 30, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29594059/severe-inflammatory-ophthalmopathy-in-a-euthyroid-patient-during-nivolumab-treatment
#4
Pauline Campredon, Philippe Imbert, Céline Mouly, Solange Grunenwald, Julien Mazières, Philippe Caron
Introduction: Nivolumab is a promising treatment in patients with advanced malignancies. Among immune-related adverse events, autoimmune thyroid disorders are frequently reported. Patient: A 61-year-old male patient had no history of familial or personal thyroid disease. In 2012, this patient, a heavy smoker, presented with non-small-cell lung cancer that was treated with radiotherapy and chemotherapy. In 2015, the cancer progressed with cervical compressive symptoms, and the patient was treated with nivolumab...
March 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29589999/biguanides-metformin-and-phenformin-generate-therapeutic-effects-via-amp-activated-protein-kinase-extracellular-regulated-kinase-pathways-in-an-in-vitro-model-of-graves-orbitopathy
#5
Ye Eon Han, Sena Hwang, Jin Hee Kim, Jung Woo Byun, Jin Sook Yoon, Eun Jig Lee
BACKGROUND: It was hypothesized that the biguanides metformin and phenformin, which are anti-hyperglycemic drugs used for diabetes mellitus, would have therapeutic effects in an in vitro model of Graves' orbitopathy (GO). Because adipogenesis, hyaluronan production, and inflammation are considered important in the pathogenesis of GO, this study aimed to determine the therapeutic effects and underlying mechanisms of biguanides on these parameters. METHODS: In vitro experiments were performed using primary cultured orbital fibroblasts from patients with GO...
March 28, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29554007/case-series-herpes-zoster-ophthalmicus-with-acute-orbital-inflammation
#6
Eunoo Bak, Namju Kim, Sang In Khwarg, Ho-Kyung Choung
SIGNIFICANCE: Herpes zoster ophthalmicus (HZO) has variable initial manifestations, and acute orbital inflammation may be the first sign without apparent zoster rash. This case series is significant for presenting diverse clinical features and treatment options of HZO with acute orbital inflammation. PURPOSE: To report a case series of patients diagnosed as HZO with acute orbital inflammation including two cases with unique presentations. CASE REPORTS: Medical records of four patients of HZO with acute orbital inflammation were reviewed...
March 16, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29515429/chronic-orbital-inflammation-associated-to-hydroxyapatite-implants-in-anophthalmic-sockets
#7
Alicia Galindo-Ferreiro, Sahar M Elkhamary, Azza Maktabi, Alberto Galvez-Ruiz, Silvana Artioli Schellini
Purpose: We report 6 patients who received a hydroxyapatite (HA) orbital implant in the socket and developed chronic orbital inflammation unresponsive to conventional medical therapy. Case Reports: We assisted 6 cases (4 males, 2 females) who received an HA orbital implant in the socket between 2015 and 2016 at King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, and developed chronic orbital inflammation with chronic discharge, redness, and pain (onset from weeks to over 2 decades after surgery)...
September 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29497344/orbital-inflammatory-complications-of-crohn-s-disease-a-rare-case-series
#8
Tanya M Monaghan, Giorgio Albanese, Philip Kaye, James D Thomas, Lorraine C Abercrombie, Gordon W Moran
Orbital inflammatory disease is a rare ophthalmic manifestation of Crohn's disease. Inflammation is characteristically nonspecific, involving one or multiple structures of the orbit. Mechanisms of disease and optimal methods of treatment are poorly understood. The aim of this report is to present 3 cases of orbital involvement in Crohn's disease. A retrospective case note review of patients with orbital inflammatory disease and Crohn's disease was performed at our academic center to determine the clinical, imaging, and histopathologic features of this condition and its relationship to intestinal Crohn's disease...
2018: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/29497337/atypical-metastasis-of-renal-cell-carcinoma-to-the-uvula-case-report-and-review-of-literature
#9
Parth Khade, Srinivas Devarakonda
Renal cell carcinoma (RCC) is a common malignancy with high metastatic potential, primarily due to its extensive vascularity. Common sites of metastasis include lungs, bone, lymph nodes, liver, and brain. However, rare cases of metastasis to other sites including inguinal lymph nodes, peritoneum/mesentery, and orbit have been published in the literature. Herein, a unique case involving metastasis of RCC to the uvula is presented. The patient is a 55-year-old White female with a past medical history of stage 3 (T3aN0M0) RCC s/p nephrectomy 3 years prior to presentation...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29493730/a-case-of-squamous-cell-carcinoma-of-the-nasal-cavity-in-a-patient-with-granulomatosis-with-polyangiitis-wegener-granulomatosis
#10
Edward C Kuan, Kevin A Peng, Lyndon O Gonzalez, Joel A Sercarz
We report a rare case of squamous cell carcinoma (SCC) of the nasal cavity arising in a patient with granulomatosis with polyangiitis (GPA). The patient was a 35-year-old man who had been diagnosed 15 years earlier with GPA and treated medically for sinonasal, pulmonary, and renal involvement. He presented to us with left-sided orbital and cheek pain and nasal obstruction. Endoscopy detected a friable, exophytic mass that involved the left lateral nasal wall and septum. Biopsy analysis identified the mass as an SCC...
January 2018: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29485563/spontaneous-resolution-of-an-orbital-mass-after-delivery-a-diagnostic-challenge
#11
Zeynep Dadaci, Cengiz Kadiyoran, Mustafa Golen, Hilal Akay Cizmecioglu
The authors report a 35-year-old woman who presented 1 month after delivery with the complaint of pain behind her left eye which started during her pregnancy. The patient described increased fullness with dependent head position and pain on left gaze but she had no proptosis and her ocular examination was normal. Magnetic resonance imaging (MRI) revealed an intraconal mass with inhomogeneous contrast enhancement. As the authors did not suspect malignity and her ocular examination was normal without any signs of inflammation, the authors followed the patient closely...
February 26, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29465483/case-series-noninflammatory-thyroid-eye-disease
#12
Shoaib Ugradar, Daniel B Rootman
PURPOSE: Patients presenting with thyroid eye disease (TED) usually follow a well-defined self-remitting course characterized by an active inflammatory phase followed by an inactive fibrotic phase. We present 3 cases where patients presented primarily with signs of progressive fibrosis and no signs of prior active inflammation. METHODS: We reviewed the clinical notes and investigations of 3 patients who presented to our center between January 2015 and August 2017...
February 16, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29453209/recurrent-epistaxis-leading-to-diagnosis-of-primary-sinonasal-melanoma
#13
Karine Tawagi, Rita Akaraz-Avedissian, Irina Burman-Solovyeva
A 48-year-old man presented to urgent care with recurrent epistaxis over 6 months. Initially, nosebleeds were controlled with packing or cautery. Ultimately, he was referred to ear, nose and throat department and underwent nasal endoscopy which revealed polypoid tissue. A biopsy of the polyp showed non-specific inflammation with no evidence of malignancy. Follow-up maxillofacial CT revealed a large mass lesion in the right maxillary sinus, right nasal fossa, much of the ethmoids and right sphenoid, with destruction of adjacent bony structures...
February 16, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29449499/clinical-correlates-outcomes-and-predictors-of-inflammatory-ocular-disease-associated-with-rheumatoid-arthritis-in-the-biologic-era
#14
Cristian Caimmi, Cynthia S Crowson, Wendy M Smith, Eric L Matteson, Ashima Makol
OBJECTIVE: Inflammatory ocular disease (IOD) is a rare but severe extraarticular manifestation of rheumatoid arthritis (ExRA) with high mortality. The aim of our study was to examine clinical characteristics of IOD in rheumatoid arthritis (RA) and their effect on disease severity and outcomes in recent years. METHODS: A retrospective cohort of RA patients with IOD evaluated between 1996 and 2013 was assembled and compared to RA comparators without IOD and matched for age, sex, and disease duration...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29431305/the-epidemiological-clinical-and-histopathological-characteristics-of-lacrimal-gland-biopsies-in-a-tertiary-care-center-in-israel
#15
Ayelet Priel, Vicktoria Vishnevskia-Dai, Liran Hochma, Juliana Gildener-Leapman, Guy J Ben Simon, Mordechai Rosner, Gal Antman, Ofira Zloto
BACKGROUND: The distribution of pathology and clinical characteristics of lacrimal gland diseases are different in different areas of the world. OBJECTIVES: To evaluate the incidence rate, patient characteristics, and indications for surgical intervention of lacrimal gland lesions in a tertiary care center in Israel. METHODS: All biopsied or surgically removed lacrimal gland lesions at the Goldschleger Eye Institute from 2009 to 2015 were identified...
February 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29426438/role-of-methotrexate-in-thyroid-related-orbitopathy
#16
Avi Rubinov, Hila Zommer, Helya Aghazadeh, Ezekiel Weis
OBJECTIVE: To report the experience of a tertiary care orbital service in treating severe active thyroid related orbitopathy with methotrexate (MTX) managed by the Ophthalmologist. DESIGN: Retrospective consecutive case series. PARTICIPANTS: Nineteen consecutive patients (5 males and 14 females) with severe active thyroid related orbitopathy. METHODS: Severe active thyroid orbitopathy patients with partial or no response to intravenous glucocorticoids were treated with MTX and observed for inflammatory scale reduction and treatment complications...
February 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29419597/orbital-schwannoma-with-atypical-presentation
#17
Stephanie M Young, Yoon-Duck Kim, Sung Soon Hwang, Kyung In Woo
Orbital schwannomas are characteristically slow-growing benign tumors arising from peripheral sensory nerves. However, the authors' case illustrates the atypical presentation of such a tumor.A 71-year-old male presented with proptosis, visual loss, and periorbital inflammation. Sequential imaging showed continuous and rapid growth of an intraconal mass arising from the medial rectus. Excision of the mass was performed and it was histopathologically proven to be an orbital schwannoma.This patient demonstrates the atypical presentation of an orbital schwannoma, arising from an extraocular muscle with rapid progressive growth and inflammation, indicating it should be considered a differential diagnosis in orbital masses presenting as such...
February 6, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29406329/no-braf-v600e-mutation-identified-in-28-periocular-pyogenic-granuloma
#18
Guosheng Li, Emily Adams, James R Eshleman, Charles G Eberhart
PURPOSE: BRAF V600E mutations were recently identified in some pyogenic granulomas of skin, particularly lesions arising in patients with port wine stains. In this study, the authors analyzed BRAF gene status in 28 periocular pyogenic granulomas to determine its role in their pathogenesis. METHODS: Retrospective review of ophthalmic pathology archives from 2007 to 2016 was used to identify pyogenic granulomas of the conjunctiva, eyelid, and orbit. Three eyelid nevi were also analyzed as positive controls...
February 5, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29398045/-management-of-orbital-inflammation-in-internal-medicine-proposal-for-a-diagnostic-work-up
#19
S Abad, F Héran, C Terrada, P Bielefeld, D Sène, S Trad, D Saadoun, P Sève
Inflammatory orbitopathies relate to an inflammatory state originating within the orbit and its adnexes, except the inner ocular globe. Orbital inflammation (OI) may be either localized manifestation of a proven or like autoimmune disease, or local response from immune system against infectious, structural or tumoral antigens. We review the clinical manifestations of OI, which provide helpful clues to the diagnosis and describe the inflammatory, infectious and neoplastic conditions classically associated with OI...
February 1, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29384827/idiopathic-sclerosing-orbital-inflammation-in-a-relapsing-polychondritis-patient-with-impaired-vision
#20
Chrong-Reen Wang, Sheng-Min Hsu, Ying-Chen Chen, Chung-Liang Ho, Sheen-Yie Fang
A 55-year-old woman with relapsing polychondritis had progressively enlarged right retro-orbital tumor invading the optic nerve, followed by left retrobulbar infiltrating lesions despite prescription of high-dose corticosteroids and pulse methylprednisolone. Repeated histopathologic analyses showed dense collagen fibers with scanty inflammatory cells, consistent with the diagnosis of idiopathic sclerosing orbital inflammation. This disorder has been recognized as a distinct entity with unique clinical features and coexisting rheumatologic disorders, requiring more focused diagnostic strategies and therapeutic regimens...
January 30, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
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