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Orbital inflammation

Kristin E Hirabayashi, Evan Kalin-Hajdu, Frank L Brodie, Robert C Kersten, Matthew S Russell, M Reza Vagefi
A 68-year-old immunocompromised man with rhino-orbital-cerebral mucormycosis was treated with retrobulbar injections of amphotericin B deoxycholate in conjunction with intravenous antifungals and endoscopic sinus debridement. Transient episodes of orbital inflammation were noted after retrobulbar injections, but progression of orbital infection was halted and visual acuity restored with eventual hospital discharge. To the authors' knowledge, clearance of orbital mucormycosis with retrobulbar amphotericin B injections has not been previously reported...
October 20, 2016: Ophthalmic Plastic and Reconstructive Surgery
Nina Marie Rzechorzek, Colin Smith, Tobias Schwarz, Tiziana Liuti, Richard Elders, Samantha Woods, Jessica Lawrence, Katia Marioni-Henry
A dog presented with a retrobulbar mass, diagnosed histopathologically as malignant spindle cell neoplasia. Emergence of analogous findings in the contralateral orbit prompted extended immunohistochemistry of the original mass and reassignment to idiopathic sclerosing orbital inflammation. Early incisional biopsy with extended immunohistochemical analysis should be considered for canine orbital tumors.
October 2016: Clinical Case Reports
Susana Vacas, Vincent Degos, Mervyn Maze
BACKGROUND: Sleep is integral to biologic function, and sleep disruption can result in both physiological and psychologic dysfunction including cognitive decline. Surgery activates the innate immune system, inducing neuroinflammatory changes that interfere with cognition. Because surgical patients with sleep disorders have an increased likelihood of exhibiting postoperative delirium, an acute form of cognitive decline, we investigated the contribution of perioperative sleep fragmentation (SF) to the neuroinflammatory and cognitive responses of surgery...
October 11, 2016: Anesthesia and Analgesia
Myhanh Nguyen, Jay Siak, Soon-Phaik Chee, Vo Quang Hong Diem
PURPOSE: To describe the pattern of uveitis among Vietnamese at two eye hospitals in Southern Vietnam. METHODS: We retrospectively reviewed the charts of 212 consecutive uveitis cases that presented to two eye hospitals in Ho Chi Minh City, Vietnam, from July 2011 to February 2015. The patients were identified from a database maintained by the hospitals. Patients with keratitis, episcleritis, orbital inflammation, post-surgical endophthalmitis, traumatic iritis, and corneal graft rejection were excluded...
October 11, 2016: Ocular Immunology and Inflammation
Dipankar Das, Panna Deka, Geeta Verma, Ganesh Chandra Kuri, Harsha Bhattacharjee, Gayatri Bharali, Divya Pandey, Akanksha Koul, Bidisha Das, Apurba Deka
Immunoglobulin G4 (IgG4-related diseases) affects various tissues and organs of the human body. Orbital, adnexal, and scleral inflammations were already reported in the medical literature. To the best of our knowledge, we report the first case of intraocular IgG4-associated inflammatory mass in the ciliary body mimicking as a melanoma in a 23-year-old female from Northeast India. Characteristic histopathology, immunohistochemistry in the tissue, protein chemistry, and raised serum IgG4 were supportive for the diagnosis...
August 2016: Indian Journal of Ophthalmology
Ilknur Tugal-Tutkun
PURPOSE OF REVIEW: The primary systemic vasculitides represent a spectrum of rare but life-threatening conditions that may also affect the eye in various forms. This article reviews recently published data on ocular manifestations of systemic vasculitis. RECENT FINDINGS: Early diagnosis and timely treatment has led to better visual outcomes in giant cell arteritis (GCA). Gene expression from orbital tissues could distinguish granulomatosis with polyangiitis (GPA) from sarcoidosis and Graves disease, but not from idiopathic orbital inflammation...
September 21, 2016: Current Opinion in Rheumatology
Bo Sun, Liyuan Song, Xinyan Wang, Jing Li, Junfang Xian, Feifei Wang, Pan Tan
PURPOSE: To investigate the diagnostic performance of diffusion-weighted imaging (DWI), dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), and the combination of both in the differential diagnosis of lymphoma and inflammation in the orbit. MATERIALS AND METHODS: This retrospective study was approved by the Institutional Review Board and the informed consent requirement was waived. A total of 53 patients underwent preoperative 3T MRI. Parameters of DWI and DCE MRI were evaluated in these 30 patients with orbital lymphoma and 23 patients with orbital inflammation...
September 20, 2016: Journal of Magnetic Resonance Imaging: JMRI
Tünde Mester, Nupur Raychaudhuri, Erin F Gillespie, Hong Chen, Terry J Smith, Raymond S Douglas
CONTEXT: Fibrocytes appear to participate in inflammation and tissue remodeling in patients with thyroid-associated ophthalmopathy (TAO). These patients have increased frequencies of circulating TSH receptor (TSHR)- and CD40-positive fibrocytes, suggesting TSHR and CD40 may play roles in proinflammatory cytokine production, which ultimately leads to orbital inflammation and tissue remodeling. OBJECTIVE: To investigate the potential interactions between the TSHR and CD40 signaling pathways and their roles in IL-6 and TNF-α production...
2016: PloS One
Gina-Eva Görtz, Mareike Horstmann, Barbara Aniol, Buena Delos Reyes, Joachim Fandrey, Anja Eckstein, Utta Berchner-Pfannschmidt
CONTEXT: In Graves' ophthalmopathy (GO) inflammation with tissue expansion in a closed compartment like the bony orbit and smoking may cause tissue hypoxia. OBJECTIVES: In this study we investigated whether Hypoxia-inducible factor-1 (HIF-1) action impacts on tissue remodeling in GO with the aim to identify possible new therapeutic targets. DESIGN/SETTING/PARTICIPANTS: Orbital fibroblast (OF) were derived from GO patients and control persons (Ctrl)...
September 9, 2016: Journal of Clinical Endocrinology and Metabolism
Ruka Nakata, Shunsuke Yoshimura, Masakatsu Motomura, Akira Tsujino, Tomayoshi Hayashi, Minoru Hara
IgG4-related disease is a systemic disease characterized by lesions with IgG4 positive plasma cell infiltration in the involved organs and a raised serum IgG4 level. We report a patient of 70-year-old male presented orbital inflammation of IgG4-related disease. The patient developed right eye pain, double vision, and reduced eye sight. MRI image revealed mild right ocular proptosis and swelling of right carvenous sinus, bilateral intraorbital extraocular muscles and right optic nerve. Right optic nerve showed ring-like enhancement...
September 29, 2016: Rinshō Shinkeigaku, Clinical Neurology
He Jack Li, Konstantinos T Tsaousis, Ashlie Bernhisel, Nicholas Reiter, Jun Jia Guan, Nick Mamalis, Bhupendra Ck Patel
No abstract text is available yet for this article.
August 25, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
Dragoş Cătălin Jianu, Silviana Nina Jianu, Ligia Petrica, Andrei Gheorghe Marius Motoc, Traian Flavius Dan, Dorela CodruŢa Lăzureanu, Mihnea Munteanu
Anterior ischemic optic neuropathies (AIONs) represent a segmental infarction of the optic nerve head (ONH) supplied by the posterior ciliary arteries (PCAs). Blood supply blockage can occur with or without arterial inflammation. For this reason, there are two types of AIONs: non-arteritic (NA-AION), and arteritic (A-AION), the latter is almost invariably due to giant cell arteritis (GCA). GCA is a primary vasculitis that predominantly affects extracranial medium-sized arteries, particularly the branches of the external carotid arteries (including superficial temporal arteries - TAs)...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Charudutt Kalamkar, Nishant Radke, Amrita Mukherjee, Snehal Radke
Orbital Apex Syndrome (OAS) is a rare complication of Herpes Zoster Ophthalmicus (HZO). We are reporting a case of 65-year-old male who developed OAS following HZO. Patient presented with vesicular rash in the typical dermatomal distribution, severe periocular congestion and limited ocular motility in all gazes along with loss of vision. Soft tissue inflammation improved within 4 weeks of initiation of treatment while ocular motility slowly improved over 3 months. Patient did not gain vision despite receiving systemic steroids and systemic anti-viral medication...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
Sun Young Jang, Min Kyung Chae, Joon H Lee, Eun Jig Lee, Jin Sook Yoon
PURPOSE: To investigate the role of microRNA 146a (miR-146a) in the regulation of inflammation in an in vitro model of Graves' orbitopathy (GO). METHODS: The level of miR-146a expression in orbital adipose tissue was compared between GO and non-GO by quantitative real-time PCR (qPCR). The effects of interleukin 1β (IL-1β) on miR-146a expression were analyzed in orbital fibroblasts by qPCR. To investigate the molecular mechanism underlying IL-1β-induced miR-146a expression, the effects of inhibitors of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), mitogen-activated protein kinase/extracellular signal-regulated kinases (MEK)-1/2, c-Jun N-terminal kinases (JNK)-1/2, p38 MAP kinase, and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) were analyzed...
August 1, 2016: Investigative Ophthalmology & Visual Science
Maheswari Muruganandam, Harbrinder Sandhu
No abstract text is available yet for this article.
October 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Hong Li, Yifei Yuan, Yali Zhang, Qianwen He, Rongjuan Xu, Fangfang Ge, Chen Wu
Graves' disease is an autoimmune disease of the thyroid gland, which is characterized by hyperthyroidism, diffuse goiter and Graves' ophthalmopathy (GO). Although several therapeutic strategies for the treatment of GO have been developed, the effectiveness and the safety profile of these therapies remain to be fully elucidated. Therefore, examination of novel GO therapies remains an urgent requirement. Celastrol, a triterpenoid isolated from traditional Chinese medicine, is a promising drug for the treatment of various inflammatory and autoimmune diseases...
September 2016: Molecular Medicine Reports
Brian D'Anza, Janalee Stokken, J Scott Greene, Thomas Kennedy, Troy D Woodard, Raj Sindwani
BACKGROUND: Chronic invasive fungal sinusitis (CIFS) is a rare subtype of mycotic diseases involving the paranasal sinuses. It is characterized by a slow onset and invasive organisms with non-granulomatous inflammation seen on histopathology. Historically, treatment has involved radical surgical resection. The purpose of this study was to describe the presentation, comorbidities, and role of more conservative treatment options. METHODS: This is a multi-institutional retrospective case series of 6 patients with CIFS over 15 years...
July 27, 2016: International Forum of Allergy & Rhinology
Alicia Galindo-Ferreiro, Laila AlGhafri, Sahar M Elkhamary, Azza Maktabi, Alberto Gálvez-Ruiz, Julio Galindo-Alonso, Silvana Schellini Proff
Two case reports are used to illustrate the signs and symptoms, complications and treatments of chronic socket inflammation due to intraorbital implants. The ophthalmic examination, surgeries and treatments are documented. Two anophthalmic cases that underwent enucleation and multiple orbital surgeries to enhance the anophthalmic socket volume developed pain, intense discharge and contracted cavities with chronic inflammation in the socket which was nonresponsive to medical therapy. Computed tomography indicated a hypodense foreign body in both cases causing an intense inflammatory reaction...
January 2016: Case Reports in Ophthalmology
Tara F Carr
BACKGROUND: Sinusitis is a common disorder associated with significant patient symptomatology that adversely affects quality of life. Sinusitis can cause further morbidity and mortality through its impact on comorbid disorders, progression of inflammation, and extension of infection. OBJECTIVE: This review highlights common complications of acute bacterial rhinosinusitis (ABRS) and chronic rhinosinusitis (CRS). RESULTS: ABRS is complicated by orbital infections, such as pre- or postseptal cellulitis, and by intracranial infections, including abscesses of the epidural and subdural spaces...
July 2016: American Journal of Rhinology & Allergy
Andrea Váncsa, Katalin Dankó
Myositis, which means inflammation of the muscles, is a general term used for inflammatory myopathies. Myositis is a rare idiopathic autoimmune disease. It is believed that environmental factors such as virus, bacteria, parasites, direct injuries, drugs side effect can trigger the immune system of genetically susceptible individuals to act against muscle tissues. There are several types of myositis with the same systemic symptoms such as muscle weakness, fatigue, muscle pain and inflammation. These include dermatomyositis, juvenile dermatomyositis, inclusion-body myositis, polymyositis, orbital myositis and myositis ossificans...
July 2016: Orvosi Hetilap
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