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Orbital inflammation

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https://www.readbyqxmd.com/read/29033638/tolosa-hunt-syndrome-cranial-neuroimaging-findings
#1
Çetin Kürşad Akpinar, Taner Özbenli, Hakan Doğru, Lütfi Incesu
INTRODUCTION: The etiology of Tolosa-Hunt Syndrome (THS) is still unknown. The initial standard magnetic resonance imaging (MRI) may not be sufficient for diagnosis, so dynamic contrast-enhanced MRI may be necessary to demonstrate the presence of lesions. METHODS: Seven patients diagnosed with THS according to the International Headache Society criteria (beta version) were included into the study. Patients were assessed in terms of type, age, symptoms and findings, accompanying disease, localization of the determined lesion, response to treatment, and clinical progress...
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29020538/orbital-inflammatory-syndrome-post-group-a-streptococcal-infection-case-series-and-review-of-literature
#2
Gilad Rabina, Igal Leibovitch, Muhammad Abumanhal, Amir Rosenblatt, Ran Ben Cnaan
OBJECTIVE: To report new cases of orbital inflammatory syndrome (OIS) post group A streptococcal (GAS) infection and review the literature. METHODS: A retrospective case series of patients with OIS post GAS infection seen in our clinic (from January 2015 to December 2016) and review of additional patients from the literature. RESULTS: A total of nine patients with OIS post GAS infection were included in the study (four patients seen in our clinic and five from previous literature); seven females and two males, three children (under the age of 16), and six adults...
October 11, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28991502/sensitivity-of-computed-tomography-for-the-assessment-of-spontaneous-dermoid-cyst-localized-rupture-with-granulomatous-reaction
#3
Alicia Galindo-Ferreiro, Sahar M Elkhamary, Saif Aldossari, Patricia M Akaishi, Hind Alkatan, Rajiv Khandekar, Denny Marcos Garcia, Yerena Muiños-Diaz, Silvana A Schellini, A Augusto V Cruz
PURPOSE: To assess the sensitivity of computed tomography for the diagnosis of spontaneous localized orbital dermoid cyst rupture with granulomatous reaction. METHODS: The charts of 42 patients with dermoid cysts were reviewed retrospectively. The data collected included demographics, clinical features, CT imaging, and postoperative histopathological analysis of the lesions. The association between radiological signs of inflammation and histopathological evidence of an inflammatory reaction was tested by univariate logistic regression...
October 9, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28990976/orbital-inflammation-as-a-presenting-sign-for-crest-syndrome
#4
Shirin W Hamed-Azzam, David P D'Cruz, David H Verity
A 61-year-old male was referred with a week's history of a painful and swollen left eye. Examination revealed normal visual acuities, left proptosis and global restriction of ocular ductions, and subretinal fluid at the macula. CT imaging confirmed thickening of the posterior scleral coat, with an associated choroidal effusion. Serology revealed positive antinuclear antibodies with a centromere staining pattern; subsequent rheumatology review revealed extensive telangiectasia with digital ulceration in both hands, and a diagnosis of limited cutaneous systemic sclerosis was made...
September 27, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28975236/gene-expression-profiling-and-heterogeneity-of-nonspecific-orbital-inflammation-affecting-the-lacrimal-gland
#5
James T Rosenbaum, Dongseok Choi, Christina A Harrington, David J Wilson, Hans E Grossniklaus, Cailin H Sibley, Sherveen S Salek, John D Ng, Roger A Dailey, Eric A Steele, Brent Hayek, Caroline M Craven, Deepak P Edward, Azza M Y Maktabi, Hailah Al Hussain, Valerie A White, Peter J Dolman, Craig N Czyz, Jill A Foster, Gerald J Harris, Youn-Shen Bee, David T Tse, Chrisfouad R Alabiad, Sander R Dubovy, Michael Kazim, Dinesh Selva, R Patrick Yeatts, Bobby S Korn, Don O Kikkawa, Rona Z Silkiss, Jennifer A Sivak-Callcott, Patrick Stauffer, Stephen R Planck
Importance: Although a variety of well-characterized diseases, such as sarcoidosis and granulomatosis with polyangiitis, affect the lacrimal gland, many patients with dacryoadenitis are diagnosed as having nonspecific orbital inflammation (NSOI) on the basis of histology and systemic disease evaluation. The ability to further classify the disease in these patients should facilitate selection of effective therapies. Objective: To test the a priori hypothesis that gene expression profiles would complement clinical and histopathologic evaluations in identifying well-characterized diseases and in subdividing NSOI into clinically relevant groups...
September 21, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28972022/risk-factors-for-extraophthalmic-involvement-and-treatment-outcomes-in-patients-with-igg4-related-ophthalmic-disease
#6
Jinku Park, Min Joung Lee, Namju Kim, Ji Eun Kim, Sun-Won Park, Ho-Kyung Choung, Sang In Khwarg
BACKGROUND/AIM: To analyse the clinical risk factors for extraophthalmic involvement and treatment outcomes in patients with IgG4-related ophthalmic disease (IgG4-ROD) in Korea. METHODS: We retrospectively reviewed medical records of 42 patients diagnosed with IgG4-ROD confirmed by a surgical biopsy during the 7-year period, between January 2009 and March 2015, at three tertiary referral centres in Korea. Data regarding patients' demographics, clinical characteristics and radiological findings were obtained...
September 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28957561/clinical-characteristics-of-inflammatory-ocular-disease-in-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-a-retrospective-cohort-study
#7
Patompong Ungprasert, Cynthia S Crowson, Rodrigo Cartin-Ceba, James A Garrity, Wendy M Smith, Ulrich Specks, Eric L Matteson, Ashima Makol
Objective: To characterize the clinical correlates and outcome of inflammatory ocular disease (IOD) among patients with ANCA-associated vasculitides (AAV). Methods: Medical records of potential cases of AAV seen at Mayo Clinic from 2003 to 2013, inclusive, were reviewed to identify confirmed cases meeting the diagnosis of AAV using the Chapel Hill Consensus Conference 2012 descriptors. Records of confirmed cases of AAV were then further reviewed for IOD, and clinical characteristics, treatment and outcomes abstracted...
October 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28957555/downregulation-of-mir-106b-attenuates-inflammatory-responses-and-joint-damage-in-collagen-induced-arthritis
#8
Yunxia Tao, Zhirong Wang, Liangliang Wang, Jiawei Shi, Xiaobin Guo, Wei Zhou, Xiexing Wu, Yu Liu, Wen Zhang, Huilin Yang, Qin Shi, Yaozeng Xu, Dechun Geng
Objective: miRNAs are small, signal-strand, non-coding RNAs that function in post-transcriptional regulation. We analysed the in vivo effect of miR-106b (miR-106b-5p) on inflammatory bone loss in CIA mice. Methods: CIA mice are developed by injecting DAB/1 mice with bovine type II collagen containing Freund's adjuvant and then the in vivo effect of miR-106b is examined. On day 22, mice were given lentiviral negative control, lentiviral-mediated miR-106b mimics or lentiviral-mediated miR-106b inhibitor via orbital injection on a weekly basis...
October 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28922676/combination-therapy-of-intravenous-steroids-and-orbital-irradiation-is-more-effective-than-intravenous-steroids-alone-in-patients-with-graves-orbitopathy
#9
Michael Oeverhaus, Tobias Witteler, Hildegard Lax, Joachim Esser, Dagmar Führer, Anja Eckstein
The aim of this study was to evaluate and compare the efficacy of intravenous (iv) glucocorticoids (GCs) with and without orbital radiotherapy (ORT) in a retrospective analysis of patients with active, moderate-to-severe Graves' orbitopathy (GO). Since diplopia has the strongest impact on quality of life, a careful work up of motility and binocular single vision (BSV) has been performed. The Essen-EUGOGO-Center database (n=3655) was screened for patients with untreated moderate-to-severe, active GO, onset ≤12 months...
October 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28893128/urticarial-reaction-following-endovascular-embolization-of-an-orbital-arteriovenous-malformation-avm-with-n-butyl-cyanoacrylate-nbca-glue
#10
Kunal R Sinha, Gary Duckwiler, Daniel B Rootman
Orbital arteriovenous malformations (AVMs) are rare vascular lesions that may be managed with endovascular embolization followed by surgical resection. Embolization is often accomplished with n-butyl-2-cyanoacrylate (nBCA), which is considered to be a safe and effective liquid occlusive agent. Localized vascular inflammation has been associated with endovascular nBCA use in histopathologic studies, but reports of systemic hypersensitivity reactions following endovascular embolization with nBCA are rare. We present a case of a 26-year-old male who developed an intermittent systemic urticarial reaction without cardiopulmonary compromise beginning four weeks after nBCA embolization of an orbital AVM...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28872378/intralesional-corticosteroid-injections-as-treatment-for-non-infectious-orbital-inflammation
#11
Sara Reggie, Michael Neimkin, John Holds
A retrospective single-center chart review identified 19 patients treated with intralesional corticosteroid injection between 2007 and 2015 for orbital inflammatory disease. Patients were treated in the office, or intraoperatively at the time of orbital exploration and biopsy, with 5-40 mg of triamcinolone acetonide. Average follow up time was 2.44 years. Information recorded included visual acuity and eyelid position measurements, pre-injection treatment, post-injection treatment, complications, and exam findings...
September 5, 2017: Orbit
https://www.readbyqxmd.com/read/28870925/usefulness-of-flow-cytometry-in-diagnosis-of-igg4-related-ophthalmic-disease-and-extranodal-marginal-zone-b-cell-lymphoma-of-the-ocular-adnexa
#12
Satoru Kase, Kan Ishijima, Takehiko Uraki, Yuka Suimon, Yasuo Suzuki, Manabu Kase, Susumu Ishida
BACKGROUND/AIM: Although flow cytometry (FCM) is used to evaluate cell surface markers of various leucocyte populations quantitatively, little is known about the usefulness of FCM in lymphoproliferative disorders of the ocular adnexa. The aim of this study was to disclose results of FCM, which were compared among IgG4-related ophthalmic disease (IgG4-ROD), idiopathic orbital inflammation (IOI), and extranodal marginal zone B-cell lymphoma (EMZL). MATERIALS AND METHODS: This is a retrospective observational study...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28863123/orbital-flourine-18-fluorodeoxyglucose-positron-emission-tomography-in-patients-with-graves-disease-for-evaluation-of-active-inflammation
#13
Lebriz Uslu-Beşli, Levent Kabasakal, Sait Sağer, Erdoğan Cicik, Sertaç Asa, Kerim Sönmezoğlu
OBJECTIVE: Prediction and early diagnosis of orbitopathy is needed in patients with Graves' disease, especially when radioiodine therapy is planned. Positron emission tomography/computerized tomography (PET/CT) using flourine-18-fluorodeoxyglucose (FDG) is an effective imaging modality in detection of inflammation, however, its ability to detect orbital inflammation has not been well studied. The aim of our study is to determine the ability of FDG PET/CT to detect orbital inflammation related with Graves' disease, identify active orbitopathy, predict the radioiodine-triggered orbitopathy, and find out the effects of radioiodine on orbital inflammation...
August 31, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28862259/lateral-canthotomy-orbitotomy-a-rapid-approach-to-the-orbit
#14
S Hamed-Azzam, D H Verity, G E Rose
PurposeThe lateral compartment of the orbit can readily be accessed through a horizontal lateral canthotomy without the need to swing the lid or remove bone. In this paper the technique, accessible orbital territory, and duration of surgery are presented.Patients and methodsRetrospective, non-interventional descriptive case series for patients who underwent a lateral canthotomy to access pathology within the lateral orbit.ResultsA series of 18 patients are included, all presenting with pathology lateral to, or within, the optic nerve...
September 1, 2017: Eye
https://www.readbyqxmd.com/read/28821195/atypical-igg4-plasmacytic-proliferations-and-lymphomas-characterization-of-11-cases
#15
Jacob R Bledsoe, Zachary S Wallace, Vikram Deshpande, Joshua R Richter, Jason Klapman, Andrew Cowan, John H Stone, Judith A Ferry
Objectives: To report the clinicopathologic features of monotypic immunoglobulin G4+ (IgG4+) lymphoid and plasmacytic proliferations. Methods: Cases were identified from the pathology files. Pathology and clinical materials were reviewed. Results: Eleven cases of monotypic IgG4+ proliferations were identified at nodal, orbital, or salivary sites. Six cases (three men, three women; age, 57-94 years) met criteria for lymphoma or plasma cell neoplasia...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28820280/review-of-periorbital-nerve-enlargement-and-biopsy-techniques
#16
Valerie H Chen, Brent R Hayek, Hans E Grossniklaus, Ted H Wojno, H Joon Kim
Periorbital nerve enlargement commonly indicates perineural invasion of malignancy or inflammatory conditions. This study reviews the role of supraorbital and infraorbital nerve biopsies in patients presenting with radiographic enlargement and to elucidate the surgical technique involved. A retrospective chart review (1997-2014) was performed at a single tertiary center. Patients with radiographic confirmation of enlarged supraorbital/infraorbital nerves that underwent biopsy were included. Charts were reviewed for: patient demographics and history, clinical symptoms and findings, radiographic findings, surgical method, and treatment...
October 2017: Orbit
https://www.readbyqxmd.com/read/28816552/the-role-of-biopsy-in-lacrimal-gland-inflammation-a-clinicopathologic-study
#17
Panitee Luemsamran, Jack Rootman, Valerie A White, Nariman Nassiri, Manraj K S Heran
PURPOSE: To determine the causes of lacrimal gland inflammation based on histopathology and systemic evaluation. METHODS: This is a retrospective case series study. From the University of British Columbia Orbit Clinic between January 1976 and December 2008, we reviewed the medical records of 60 patients who presented with inflammatory features of the lacrimal gland (i.e., erythema, edema, or tenderness) in which the diagnoses were not possible clinically and on imaging alone...
August 17, 2017: Orbit
https://www.readbyqxmd.com/read/28812938/unilateral-optic-perineuritis-due-to-nonspecific-orbital-inflammation-a-case-report
#18
Pinar Nalcacioglu, Golge Acaroglu
Nonspecific orbital inflammation is an idiopathic chronic tumor-like inflammation process that usually affects the orbital tissues of both eyes. Isolated optic nerve involvement by an idiopathic inflammatory process is a rare finding. Here, we report a patient with unilateral sudden onset severe orbital pain and headache with visual loss to no light perception that could only be attributed to perineuritis. Radiological findings enabled making the correct diagnosis. Various relevant diagnoses are also discussed...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28812921/a-case-of-concurrent-silent-sinus-syndrome-thyroid-eye-disease-idiopathic-orbital-inflammatory-syndrome-and-dacryoadenitis
#19
Wen-Shi Shieh, Alison B Huggins, Mindy R Rabinowitz, Marc R Rosen, Michael P Rabinowitz
This is a retrospective case description of a single female patient found to have concomitant bilateral silent sinus syndrome, bilateral thyroid eye disease, unilateral dacryoadenitis, and idiopathic orbital inflammation that presented as progressive unilateral right-sided proptosis. The spectrum of inflammatory orbital diseases can make discerning between different entities challenging, but more unique in this case was the simultaneous presentation with bilateral silent sinus syndrome, a rare entity in its own right...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28812911/isolated-orbital-mucoceles-in-the-absence-of-obstructive-sinus-disease
#20
M A Prendes, I Perszyk, D Horkey, J Sokol, P Timoney
Orbital surgeons are quite familiar with the diagnosis and management of paranasal sinus mucoceles due their frequent involvement of the orbit. These benign masses form and expand following sinus outflow obstruction secondary to various causes including trauma, inflammation and malignancy, amongst others. The authors present two cases of isolated orbital mucoceles without associated sinus outflow obstruction. There were notably no connections between the paranasal sinuses and the lesions. The mucoceles were diagnosed following orbitotomies and excisional biopsies with confirmatory histopathology...
August 16, 2017: Orbit
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