Ximing Shao, Katya Krieger-Redwood, Meichao Zhang, Paul Hoffman, Lucilla Lanzoni, Robert Leech, Jonathan Smallwood, Elizabeth Jefferies
The default mode network (DMN) typically deactivates to external tasks, yet supports semantic cognition. It comprises medial temporal (MT), core, and fronto-temporal (FT) subsystems, but its functional organisation is unclear: the requirement for perceptual coupling versus decoupling, input modality (visual/verbal), type of information (social/spatial) and control demands all potentially affect its recruitment. We examined the effect of these factors on activation and deactivation of DMN subsystems during semantic cognition, across four task-based human functional magnetic resonance imaging (fMRI) datasets, and localised these responses in whole-brain state space defined by gradients of intrinsic connectivity...
April 8, 2024: Journal of Neuroscience