Elena Zamagni, Stefania Oliva, Francesca Gay, Andrea Capra, Delia Rota-Scalabrini, Mattia D'Agostino, Angelo Belotti, Monica Galli, Manuela Racca, Renato Zambello, Barbara Gamberi, Domenico Albano, Luca Bertamini, Annibale Versari, Mariella Grasso, Nicola Sgherza, Claudia Priola, Francesca Fioritoni, Francesca Patriarca, Gabriella De Cicco, Tania Villanova, Anna Pascarella, Pietro Zucchetta, Paola Tacchetti, Stefano Fanti, Katia Mancuso, Simona Barbato, Mario Boccadoro, Pellegrino Musto, Michele Cavo, Cristina Nanni
BACKGROUND: 18F-FDG-PET/CT is the current standard technique to define minimal residual disease (MRD) outside the bone marrow (BM) in multiple myeloma (MM), recently standardised applying the Deauville scores (DS) to focal lesions (FS) and bone marrow uptake (BMS) and defining the complete metabolic response (CMR) as uptake below the liver background (DS <4). METHODS: In this analysis, we aimed at confirming the role of CMR, and complementarity with BM multiparameter flow cytometry (MFC) at 10-5 , in an independent cohort of newly diagnosed transplant-eligible MM patients previously enrolled in the phase II randomised FORTE trial...
June 2023: EClinicalMedicine