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Parotid gland

Hannah Shoval, Esther Antelis, Andrew Hillman, Xiaofang Wei, Patricia Tan, Ruth Alejandro, Heakyung Kim
OBJECTIVE: To investigate the safety and efficacy of Onabotulinum Toxin-A (BTX-A) injection to the salivary glands under ultrasound guidance for the treatment of sialorrhea in patients with spinal muscular atrophy type I (SMA I). DESIGN: Prospective case series with four patients with SMA I who received BTX-A injection to parotid and submandibular glands for sialorrhea as part of clinical care. All four patients received validated surveys for measuring drooling, including objective measures of number of bib changes, and number of mouth wipes before injection and 4-6 weeks after injection...
June 18, 2018: American Journal of Physical Medicine & Rehabilitation
Jack W O'Sullivan, Tim Muntinga, Sam Grigg, John P A Ioannidis
OBJECTIVE: To provide an overview of the evidence on prevalence and outcomes of incidental imaging findings. DESIGN: Umbrella review of systematic reviews. DATA SOURCES: Searches of MEDLINE, EMBASE up to August 2017; screening of references in included papers. ELIGIBILITY CRITERIA: Criteria included systematic reviews and meta-analyses of observational studies that gave a prevalence of incidental abnormalities ("incidentalomas")...
June 18, 2018: BMJ: British Medical Journal
Mateusz Falkowski, Mateusz Maciejczyk, Tomasz Koprowicz, Bożena Mikołuć, Anna Milewska, Anna Zalewska, Halina Car
Whey protein concentrate (WPC) is characterized by powerful antioxidant properties, but its effect on redox homeostasis of salivary glands of aging organisms is still unknown. In this study, we are the first to evaluate the antioxidant barrier of salivary glands of 14-month Wistar rats fed WPC-80. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) as well as concentrations of reduced glutathione (GSH) are estimated in the submandibular and parotid glands of rats administered WPC-80 intragastrically for a period of 7 and 14 days...
June 17, 2018: Nutrients
T Mukaibo, T Munemasa, C Masaki, C Y Cui, J E Melvin
Mutations in the ectodysplasin A gene ( EDA) cause X-LHED (X-linked hypohidrotic ectodermal dysplasia), the most common human form of ectodermal dysplasia. Defective EDA signaling is linked to hypoplastic development of epithelial tissues, resulting in hypotrichosis, hypodontia, hypohidrosis, and xerostomia. The primary objective of the present study was to better understand the salivary gland dysfunction associated with ectodermal dysplasia using the analogous murine disorder. The salivary flow rate and ion composition of the 3 major salivary glands were determined in adult Eda-deficient Tabby hemizygous male (Ta/Y) and heterozygous female (Ta/X) mice...
June 1, 2018: Journal of Dental Research
Apiruk Sangsin, Hideki Murakami, Takaki Shimizu, Satoshi Kato, Hiroyuki Tsuchiya
Acinic cell carcinoma metastasizing to the spine is extremely rare. The authors present a case of acinic cell carcinoma of the parotid gland with subsequent lung and spinal metastases, treated with en bloc spondylectomy. A 41-year-old man presented with a left parotid mass. After being diagnosed with acinic cell carcinoma, he underwent a total parotidectomy. Imaging studies revealed a metastatic osteoblastic lesion in the T4 vertebral body and multiple lung metastases. Total en bloc spondylectomy and reconstruction with a frozen tumor-bearing bone graft were performed to treat the T4 metastasis...
June 18, 2018: Orthopedics
Anuj Sarma
Sjögren syndrome is an autoimmune disorder characterized by lymphocytic infiltration of exocrine gland. The most common symptom by virtue of its involvement includes dryness of eyes, mouth, and parotid gland enlargement. However, the disease may be associated with extraglandular manifestation affecting multiple organs. Such a presentation involves renal involvement with tubular dysfunction manifesting as severe hypokalemia.
March 2018: Indian Journal of Endocrinology and Metabolism
Claudia Scherl, Masanari G Kato, Evren Erkul, Evan M Graboyes, Shaun A Nguyen, Angela C Chi, Patrick F Morgan, Terry A Day
OBJECTIVES: To evaluate the demographics, clinical features, survival outcomes, and prognostic indicators of patients with acinic cell carcinoma (ACC) of the parotid gland with emphasis on the roles of grade, tumor size, and nodal status in survival. MATERIALS AND METHODS: A retrospective analysis of cases diagnosed between 2004 and 2012 from the National Cancer Database was performed. Multivariable logistic regression was used to determine factors associated with survival...
July 2018: Oral Oncology
E Boon, M H Valstar, W T A van der Graaf, E Bloemena, S M Willems, C A Meeuwis, P J Slootweg, L A Smit, M A W Merkx, R P Takes, J H A M Kaanders, P J T A Groenen, U E Flucke, C M L van Herpen
OBJECTIVES: In 2010, a new subtype of salivary gland cancer (SGC), (mammary analogue) secretory carcinoma (SC), was defined, characterized by the ETV6-NTRK3 fusion gene. As clinical behavior and outcome data of this histological subtype tumor are still sparse, we aimed to describe the clinicopathological course and outcome of a series of translocation positive SC patients. PATIENT AND METHODS: We re-evaluated the pathological diagnosis of a subset of SGCs, diagnosed in 4 of 8 Dutch head and neck centers...
July 2018: Oral Oncology
Konstantinos Mantsopoulos, Michael Koch, Miguel Goncalves, Heinrich Iro
OBJECTIVES: The aim of the study was to compare multifocal extracapsular dissection with complete parotidectomy in the treatment of unilateral multifocal cystadenolymphomas of the parotid gland. MATERIALS AND METHODS: The records from all patients treated for unilateral multifocal cystadenolymphomas of the parotid gland at a tertiary referral center between 2000 and 2016 were retrospectively analyzed. RESULTS: 203 patients were included in the study...
July 2018: Oral Oncology
Tetsushi Aizawa, Masahiro Kuwabara, Satoshi Kubo, Shimpo Aoki, Ryuichi Azuma, Tomoharu Kiyosawa
BACKGROUND: Frey syndrome is one of the important complications of parotid surgery. Placing a barrier between the parotid gland and the skin flap is considered to be effective for preventing this syndrome by blocking misdirected regeneration of nerve fibers. Neoveil is nonwoven polyglycolic acid (PGA) felt that is used as absorbable reinforcing material. The present study evaluated the effectiveness of this PGA felt as a barrier for preventing Frey syndrome. METHODS: A total of 19 patients who underwent superficial parotidectomy from 2012 to 2017 were retrospectively reviewed...
June 13, 2018: Annals of Plastic Surgery
Debasis Gochhait, Arun Alexender, Priyadarshini Dehuri, Vidhyalakshmi Rangarajan, Sajini Elizabeth Jacob, Neelaiah Siddaraju
Isolated invasive Mucormycosis of the parotid gland is rarely reported in the literature (1). Mucormycosis most commonly manifests as rhino-oculocerebral and pulmonary infections in the patients with altered immunity (uncontrolled Diabetes mellitus, recipients of immunosupressive therapy and underlying hematological malignancies) (2). Rarely, it causes infection in the immunocompetent individuals (3) with the involvement of unusual sites like gastrointestinal tract, ear, soft tissue and skin (4, 5). This article is protected by copyright...
June 15, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Allen M Chen, Taeko Yoshizaki, Pin-Chieh Wang, Darlene Veruttipong, Phillip J Beron, Robert Chin, Argin G Mikaeilian, Minsong Cao
Purpose: The practice of deliberately sparing the ipsilateral parotid gland with intensity modulated radiation therapy (IMRT) in patients with node-positive head and neck cancer is controversial. We sought to compare the clinical outcomes among consecutive cohorts of patients with head and neck cancer who were treated with differing strategies to spare the parotid gland that is ipsilateral to the involved neck using IMRT. Methods and materials: A total of 305 patients were treated with IMRT for node-positive squamous cell carcinoma of the head and neck...
April 2018: Advances in Radiation Oncology
Jenny Joselyne Sotelo-Gavito, Mariana Pérez-Montaño, Georgia Alderete-Vázquez, Guadalupe Capetillo-Hernández, Peter Grube-Pagola
Background: The aim of this paper was to know the epidemiological characteristics of the salivary gland tumors in a Mexican population. Methods: A descriptive, retrospective and cross-sectional study was performed. All cases of salivary gland tumor were collected in a period of 5 years (2009-2014) in two hospitals of our State, the Hospital General de Veracruz and the Unidad Médica de Alta Especialidad y Hospital de Especialidades No. 14, with the study of variables like: age, gender, location, biological behavior and histological type...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
Xin Guo, Jiro Watanabe, Sanae Ariyasu, Yasuyuki Sasaguri, Nozomu Kurose, Kei Fukushima, Sohsuke Yamada
An 80-year-old male presented with a history of a hard right parotid mass that had gradually increased in size, with subsequent facial paralysis. A fine-needle aspiration biopsy was performed. The cytologic specimens contained a substantial number of sheet-like clusters or small groups of a mixture of plasmacytoid, oval to spindled, or large epithelioid cells having hyperchromatic pleomorphic nuclei, abundant cytoplasm with occasional inclusion body-like materials, and prominent nucleoli, in a relatively clear background...
2018: SAGE Open Medical Case Reports
Mehmet Kemal Tumer, Mustafa Cicek
OBJECTIVE: This study aimed to demonstrate the immunohistochemical changes associated with MMP-2 and type 1 collagen separately for the first time in the major salivary glands (the parotid, submaxillary, and sublingual glands) that occur with aging in mice. MATERIAL AND METHODS: Fourteen Balb/c white mice (50-80 g) were used in this study. The animals were divided into two equal groups. Group I consisted of young animals (2-month-old) (n=7) and Group II consisted of older animals (18-month-old) (n=7)...
June 11, 2018: Journal of Applied Oral Science: Revista FOB
Wen Yu Wong, Maricela Pier, Kirsten H Limesand
Xerostomia and hyposalivation are debilitating side effects for patients treated with ionizing radiation for head and neck cancer. Despite technological advances, collateral damage to the salivary glands remains a significant problem for patients and severely diminishes their quality of life. During the wound healing process, restoration of junctional contacts is necessary to maintain polarity, structural integrity, and orientation cues for secretion. However, little is known about whether these structural molecules are impacted following radiation damage and more importantly during tissue restoration...
June 13, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Zhiwei Zheng, Jun Li, Jinbing Wang, Jian Sun
OBJECTIVES: The purpose of this article was to propose a V-shaped minimal facelift incision (FLI) and analyze its efficacy for improving the esthetic outcomes of parotid gland tumors. METHODS: A prospective, nonrandomized study was performed. Forty-six patients with category I benign parotid tumors as to Quer classification (3 cm or less and located superficially and/or peripherally in the gland) were enrolled. The 46 patients who underwent dissection of parotid gland tumors were divided into 2 groups: minimal FLI (group 1) and modified Blair incision (MBI, group 2)...
June 11, 2018: Journal of Craniofacial Surgery
Hui Wu, Xiaojian Chen, Xin Yang, Yalan Tao, Yunfei Xia, Xiaowu Deng, Cheng Zheng, Jared Robbins, Christopher Schultz, X Allen Li
PURPOSE: To investigate radiation-induced changes of computed tomography (CT) textures in parotid glands (PG) to predict acute xerostomia during radiotherapy (RT) for head and neck cancer (HNC). METHODS AND MATERIALS: Daily or fraction kilovoltage CTs acquired using diagnostic CT scanners (eg, in-room CTs) during intensity-modulated RT for 59 HNC patients at 3 institutions were analyzed. The PG contours were generated on selected daily/fraction CTs. A series of histogram-based texture features, including the mean CT number (MCTN) in Hounsfield units, volume, standard deviation, skewness, kurtosis, and entropy for PGs were calculated for each fraction...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Kwame Doh, Ibou Thiam, Romulus Carmen Adechina Takin, Khaled Sonhaye, Gisèle Woto-Gaye
INTRODUCTION: Sebaceous lymphadenoma of the parotid (SLP) is a rare, benign tumor with similar epidemiological and macroscopic characteristics with other sebaceous differentiated tumors of the parotid (SDTP). The authors report a case of SLP in an 80-year-old woman. They then recall the distinctive histological and immunohistochemical criteria of SDTP. OBSERVATION: Mrs P. D. was received during a surgical consultation for the management of a painless right parotid swelling that has evolved for 10years, increasing slightly in volume...
June 4, 2018: Annales de Pathologie
Masamichi Koyama, Takashi Terauchi, Mitsuru Koizumi, Hiroko Tanaka, Yukiko Sato
RATIONALE: Pleomorphic adenoma, the most common tumor of the salivary glands, is usually benign. It is well known, however, that pleomorphic adenomas occasionally undergo malignant transformation to carcinoma ex pleomorphic adenoma and can metastasize. More rarely pleomorphic adenomas can metastasize without histological malignant transformation. We herein report an unusual case of pleomorphic adenoma with multiple metastases comprehensively demonstrated on F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT)...
June 2018: Medicine (Baltimore)
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