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Parotid gland

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https://www.readbyqxmd.com/read/29243771/role-of-bcl-2-and-bax-in-parotid-gland-atrophy
#1
J-H Zuo, C-H Sun, H Gao, L-F Wang, Y-H Zhu
OBJECTIVE: To investigate the expression and correlation of B-cell lymphoma-2 (Bcl-2) and Bax in the parotid gland after leading duct ligation in rat. MATERIALS AND METHODS: Atrophy of the right parotid was induced by ligating the right Stensen's duct of rats. Immunohistochemical labeling was performed to study the changes in number and distribution of Bcl-2 and Bax in each step of glandular atrophy, and every group at 1, 3, 5, 7, 14, 21, 30, 60, 90, 150, 180 days after ligation...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243502/evidence-based-management-of-incidental-focal-uptake-of-fluorodeoxyglucose-on-pet-ct
#2
Deborah Pencharz, Malavika Nathan, Thomas L Wagner
Focal incidental uptake, with or without CT abnormalities, is a common finding on FDG PET/CT and evidence based management for this type of uptake is lacking. This article reviews the evidence on focal incidental uptake including the incidence of malignancy, differential diagnosis and imaging criteria which can be used to further characterise it. The article focusses on PET rather than CT criteria. The strength of the evidence base is highly variable ranging from systematic reviews and meta-analyses to a virtual absence of evidence...
December 15, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29242731/recurrent-follicular-dendritic-cell-sarcoma-of-the-parotid-gland-imaged-with-18f-fdg-pet-ct
#3
William Makis, E W Hudson, Brian Chiu
Follicular dendritic cell sarcoma (FDCS) is an extremely rare tumor with only 67 cases of head and neck FDCS reported in the literature. A 65-year-old female had a 6-cm follicular dendritic cell sarcoma resected from the left parotid gland with close margins. It recurred 1 year later as a 5-cm mass that was intensely [18F] fluoro-2-deoxy-D-glucose (18F-FDG) avid on positron emission tomography/computed tomography (PET/CT) and was re-excised. A follow-up PET/CT did not show any metastatic disease. The use of 18F-FDG PET/CT in the management of FDCS warrants further research...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29240035/acinic-cell-carcinoma-of-the-parotid-gland-in-children-and-adolescents
#4
Shifra Ash, Isaac Yaniv, Raphael Feinmesser, Osnat Konen, Meora Feinmesser
Acinic cell carcinoma of the parotid gland is a rare low-grade malignant neoplasm. Data on children are sparse. For the present study, the database of a tertiary pediatric medical center was reviewed for all patients with parotid gland acinic cell carcinoma diagnosed and treated between 2004 and 2013. Clinical, histologic, treatment, and outcome parameters were collected from the medical files. Four patients were identified, 3 female and 1 male, aged 13.5 to 18 years (median 15.7) at diagnosis. One patient had a family history of parotid tumor and 1 of hypothyroidism/hyperthyroidism...
December 12, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29239938/latest-advances-in-ultrasound-assessment-of-salivary-glands-in-sj%C3%A3-gren-syndrome
#5
María Victoria Martire, María Lida Santiago, Tomas Cazenave, Marwin Gutierrez
OBJECTIVE: There are different imaging techniques to assess the parotid glands (i.e., sialography, salivary gland scintigraphy) in patients with Sjögren syndrome (SS). However, their use is limited by the invasive character or high cost. Ultrasound (US) is gaining interest by rheumatologists as a complementary diagnostic tool for SS. To date, there is an increasing body of evidence supporting its sensitivity in the assessment of salivary glands in SS. The aim of our study was to analyze the potential role of US as a diagnostic and prognostic tool in SS and to discuss existing evidence to support its application use...
December 12, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29238673/sialendoscopic-approach-in-management-of-juvenile-recurrent-parotitis
#6
P P Singh, M Goyal, A Goyal
To assess the role of sialendoscopy as a diagnostic and therapeutic modality in juvenile recurrent parotitis. Juvenile recurrent parotitis (JRP) is the second most frequent salivary gland disease in childhood and is characterized by recurrent non suppurative and non obstructive parotid inflammation. These attacks influence the quality of life and can even lead to gland destruction, and there are no definitive treatment to avoid them. Sialendoscopic dilatation is emerging as the new treatment modality in this aspect...
December 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29236363/diabetic-status-influences-the-storage-of-melatonin-in-human-salivary-glands
#7
Michela Isola, Maria Alberta Lilliu, Francesco Loy, Raffaella Isola
Recently we reported on the detailed localization of melatonin (and its receptors) in human salivary glands, revealing that serous cells are able to store and secrete melatonin into saliva. Since we found that type 2 diabetic patients display reduced melatonin content in saliva, our next step was to examine the presence of melatonin in salivary glands removed from type 2 diabetic subjects. The resulting data were compared with those previously obtained by identical procedures in non diabetics, to establish if the diabetic status may affect melatonin distribution...
December 13, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29233833/scoring-hypoechogenic-areas-in-one-parotid-and-one-submandibular-gland-increases-feasibility-of-ultrasound-in-primary-sj%C3%A3-gren-s-syndrome
#8
Esther Mossel, Suzanne Arends, Jolien F van Nimwegen, Konstantina Delli, Alja J Stel, Frans G M Kroese, Fred K L Spijkervet, Arjan Vissink, Hendrika Bootsma
OBJECTIVE: To assess whether ultrasonographic scoring of (i) both parotid and submandibular salivary glands and (ii) all individual components of the Hocevar scoring system, is needed for classifying patients as primary Sjögren's syndrome (pSS). METHODS: Ultrasound examination of the major salivary glands (sUS) was performed in 204 consecutive patients clinically suspected (n=171) or diagnosed (n=33) with pSS.Parenchymal echogenicity, homogeneity, hypoechogenic areas, hyperechogenic reflections and salivary gland posterior border were scored in left and right parotid and submandibular glands...
December 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29229364/pathology-and-management-of-masses-in-the-accessory-parotid-gland-region-24-year-experience-at-a-single-institution
#9
Hailong Ma, Shufang Jin, Zhong Du, Lizhen Wang, Zhiyuan Zhang, Yan'an Wang
PURPOSE: Masses in the accessory parotid gland (APG) region are clinically rare and their management can lead to conflicts between the need for tumor resection and facial cosmesis. The aim of this study was to analyze the pathological classifications and management of APG lesions in our hospital. MATERIALS AND METHODS: From January 1993 to March 2017, 130 patients with primary tumors in the APG region who underwent surgical treatment were enrolled. Follow-up surveys after surgery were then carried out...
November 17, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29224806/oncogenic-dna-viruses-found-in-salivary-gland-tumors
#10
Alyce A Chen, Tarik Gheit, Marco Stellin, Valentina Lupato, Giacomo Spinato, Roberto Fuson, Anna Menegaldo, Sandrine Mckay-Chopin, Elisa Dal Cin, Giancarlo Tirelli, Maria Cristina Da Mosto, Massimo Tommasino, Paolo Boscolo-Rizzo
BACKGROUND: Previous investigations studying the association of DNA viruses with salivary gland tumors (SGTs) have led to conflicting results. The aim of this study was to determine the prevalence of different DNA viruses by using a highly sensitive assay in a multi-center series of over 100 fresh frozen salivary gland samples. METHODS: DNA was isolated from 84 SGTs (80 parotid tumors and 4 submandibular gland tumors) and 28 normal salivary tissue samples from 85 patients in Northeast Italy...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29223310/cystinuria-one-possible-reason-for-kidney-and-salivary-gland-lithiasis-relationship
#11
Marc-Kevin Le Roux, Nicolas Graillon, Jean-Marc Foletti, Cyrille Chossegros
Salivary gland lithiasis affects 1 to 2% of adults. The submandibular glands are concerned in 87% of cases. An association between kidney and salivary lithiases, although often mentioned, has rarely been observed. We relate an exceptional case of parotid and submandibular cystine sialolithiasis with kidney cystine lithiasis in a patient with cystinuria. Cystine lithiasis occurs in 1% of kidney lithiasis cases. The purpose of this article is to discuss the arguments, diagnosis, and therapeutic attitude in front of salivary cystine lithiasis...
November 22, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29219039/morphogenesis-and-mucus-production-of-epithelial-tissues-of-three-major-salivary-glands-of-embryonic-mouse-in-3d-culture
#12
Azusa Nakao, Takumi Inaba, Akiko Murakami-Sekimata, Hiroyuki Nogawa
Embryonic mouse submandibular epithelia initiate branching morphogenesis within two days when embedded in Matrigel and stimulated by members of the epidermal growth factor family. However, it is unknown whether the end buds further branch over longer culture periods, and whether saliva-producing cells differentiate there. In the present study, we cultivated three major (submandibular, sublingual and parotid) salivary epithelia from 13-day embryos for 14 days in mesenchyme-free cultures. All epithelia continued to grow and branch to form numerous acinus-like structures in medium supplemented with neuregulin 1, fibroblast growth factor 1, and insulintransferrin-sodium selenite...
December 2017: Zoological Science
https://www.readbyqxmd.com/read/29217121/diagnostic-and-treatment-effects-of-sialendoscopy-for-patients-with-swelling-of-the-parotid-gland-when-sialoliths-are-undetected-with-computed-tomography
#13
Norio Kondo, Toshio Yoshihara, Yukie Yamamura, Kaoru Kusama, Eri Sakitani, Yukako Seo, Mayako Tachikawa, Keiko Kujirai, Erika Ono, Yasuyo Maeda, Tomohito Nojima, Akiko Tamiya, Emiri Sato, Manabu Nonaka
Between August 2009 and May 2016, 74 patients underwent sialoendoscopic surgery. 32 patients had parotid gland disease and 9 patients had intermittent swelling of the parotid gland and sialoliths were not detected with CT imaging. 4 patients were diagnosed with idiopathic Stensen's duct stenosis. Sialendoscopy directly confirmed Stensen's duct stenosis in 2 patients. However, the sialendoscope was unable to be inserted in the other 2 patients, who had stenosis of the orifice of the Stensen's duct. Balloon expansion of the duct was performed in these 2 patients and a steroid drug was injected into the duct in one patient...
December 4, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29214984/electron-beam-collimation-with-the-photon-mlc-for-standard-electron-treatments
#14
Silvan Mueller, Michael K Fix, Dominik Henzen, Daniel Frei, Daniel Frauchiger, Kristina Loessl, Marco F M Stampanoni, Peter Manser
Standard electron treatments are nowadays still performed using standard or molded patient-specific cut-outs placed in the electron applicator. Replacing cut-outs and electron applicators with the photon multileaf collimator (pMLC) for electron beam collimation would make standard electron treatments more efficient and would facilitate advanced treatment techniques like modulated electron radiotherapy (MERT) and mixed beam radiotherapy (MBRT). In this work, a multiple source Monte Carlo beam model for pMLC shaped electron beams commissioned at a source to surface distance (SSD) of 70 cm is extended for SSDs up to 100 cm and validated for several Varian treatment units with field sizes typically used for standard electron treatments...
December 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29212872/parotid-gland-an-unusual-site-of-breast-cancer-metastasis
#15
Thomas Rawet, Apurna Jegannathen, Soni Soumian
Parotid gland metastases from breast cancer are an extremely rare and unusual event with a limited number of cases recorded in the literature. A 71-year-old woman with a history of ductal adenocarcinoma of the left breast presented to the maxillofacial clinic with an asymptomatic swelling of the left parotid gland. The presentation occurred 21 years after she underwent treatment for recurrent breast cancer. Investigations led to the diagnosis of a breast cancer metastasis which was oestrogen receptor and progesterone receptor positive and negative...
December 5, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29205961/her2-her3-positive-metastatic-salivary-duct-carcinoma-in-the-pleural-effusion-a-case-report
#16
Kazuya Murata, Akihiko Kawahara, Takeharu Ono, Yorihiko Takase, Hideyuki Abe, Yoshiki Naito, Jun Akiba
Salivary duct carcinoma (SDC) is an aggressive form of salivary gland tumor, and SDC patients tend to be older men, more commonly in advanced stage with a poorer prognosis. Although the cytological characteristics of SDC on fine-needle aspiration cytology have been well-described at the primary site, they have not been explored in metastasis. Here we reported a case of HER2/HER3-positive metastatic SDC in the lung and pleural effusion. The patient was a man in his 50s who had undergone extended total parotidectomy in 2008...
December 4, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29204918/sialendoscopy-in-treating-pediatric-salivary-gland-disorders-a-systematic-review
#17
REVIEW
Yehuda Schwarz, Aren Bezdjian, Sam J Daniel
OBJECTIVE: The primary aim of this study is to conduct a systematic review in order to evaluate the use of sialendoscopy in treating pediatric salivary gland disorders. METHODS: Eligible articles were identified through a comprehensive search of electronic databases. Using predefined inclusion criteria, published articles on sialendoscopy in children were selected and reviewed. RESULTS: 17 articles including 323 pediatric patients and 424 salivary glands managed by sialendoscopy were identified...
December 4, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29200960/solitary-fibrous-tumor-occurring-in-the-parotid-gland-a-case-report
#18
Meryem Rais, Amine Kessab, Zahra Sayad, Sanae El Mourabit, Redallah Zrarqi, Salma Benazzou, Malik Boulaadas, Nadia Cherradi
Background: Solitary fibrous tumor is an uncommon spindle cell neoplasm of unknown origin. It has been reported in many anatomic sites, with a rare occurrence in the head and neck region. Solitary fibrous tumors of the parotid gland are exceptional; their clinical and radiologic features are non specific, often mimicking more common salivary gland tumors. Pathologic examination and immunohistochemistry are required to make the correct diagnosis. The prognosis is favorable, with most tumors being benign, and complete surgical resection is the treatment of choice...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29197363/metastatic-retinoblastoma-of-the-parotid-and-submandibular-glands-a-rare-case-report
#19
Ping Wang, Yang-Jun Li, Shao-Bo Zhang, Qi-Lin Cheng, Qiong Zhang, Li-Sha He
BACKGROUND: Retinoblastoma is the most common intraocular malignancy occurring in children. It can metastasize to the regional lymph nodes, central nervous system and distant organs usually the bones and bone marrow and very rarely to the soft tissue. Here, we report a case of unilateral retinoblastoma in a 4-year-old girl accompanied by a large metastasis of the parotid and submandibular glands that developed about 6 months previously and gradually increased in size 5 months after enucleation of the left eye...
December 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29197149/cd29-is-highly-expressed-on-epithelial-myoepithelial-and-mesenchymal-stromal-cells-of-human-salivary-glands
#20
Padma Priya Togarrati, Nuntana Dinglasan, Shivani Desai, William R Ryan, Marcus O Muench
OBJECTIVE: The phenotype of the cells present in the ductal region of salivary glands have been well characterized. However, it is imperative to identify novel biomarkers that can identify different cell types present in other glandular components for the development of therapeutic strategies and diagnostics of salivary gland disorders and malignancies. Our study aimed at the characterization of the expression and distribution of various cell surface markers, especially with a focus on CD29 in human fetal as well as adult glands...
December 2, 2017: Oral Diseases
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