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https://www.readbyqxmd.com/read/28485775/determination-of-phloroglucinol-by-hplc-ms-ms-and-its-application-to-a-bioequivalence-study-in-healthy-volunteers
#1
X-Q Li, R-T Wang, Q-H Wang, X-L Tang, C-T Lu, H-G Gong, A-D Wen
OBJECTIVE: The aim of this study was to compare the pharmacokinetic characteristics of phloroglucinol between an orally disintegrating tablet and an orally lyophilized tablet of phloroglucinol in healthy volunteers under fasting condition. PATIENTS AND METHODS: A rapid and simple method based on high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method has been developed and validated for the determination of phloroglucinol in human plasma...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28475418/asp30-of-aspergillus-oryzae-cutinase-cutl1-is-involved-in-the-ionic-interaction-with-fungal-hydrophobin-rola
#2
Yuki Terauchi, Yoon-Kyung Kim, Takumi Tanaka, Kei Nanatani, Toru Takahashi, Keietsu Abe
Aspergillus oryzae hydrophobin RolA adheres to the biodegradable polyester polybutylene succinate-co-adipate (PBSA) and promotes PBSA degradation by interacting with A. oryzae polyesterase CutL1 and recruiting it to the PBSA surface. In our previous studies, we found that positively charged amino acid residues (H32, K34) of RolA and negatively charged residues (E31, D142, D171) of CutL1 are important for the cooperative ionic interaction between RolA and CutL1, but some other charged residues in the triple mutant CutL1-E31S/D142S/D171S are also involved...
May 5, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28464095/breeding-and-genetics-symposium-resilience-and-lessons-from-studies-in-genetics-of-heat-stress
#3
I Misztal
Production environments are expected to change, mostly to a hotter climate but also possibly more extreme and drier. Can the current generation of farm animals cope with the changes or should it be specifically selected for changing conditions? In general, genetic selection produces animals with a smaller environmental footprint but also with smaller environmental flexibility. Some answers are coming from heat-stress research across species, with heat tolerance partly understood as a greater environmental flexibility...
April 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28357445/the-decade-of-roma-inclusion-did-it-make-a-difference-to-health-and-use-of-health-care-services
#4
János Sándor, Zsigmond Kósa, Klára Boruzs, Julianna Boros, Ildikó Tokaji, Martin McKee, Róza Ádány
OBJECTIVES: We investigated whether the severely disadvantaged health of Hungarian Roma adults living in segregated settlements changed by the Decade of Roma Inclusion program. METHODS: We compared the results of two paired health interview surveys that we carried out using the same methodology before and after the Decade, on the general Hungarian and Roma populations. RESULTS: Self-perceived health status of younger Roma worsened, while it improved among older Roma...
March 29, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28314101/dielectrophoresis-system-for-testing-antimicrobial-susceptibility-of-gram-negative-bacteria-to-%C3%AE-lactam-antibiotics
#5
I-Hsiu Su, Wen-Chien Ko, Chung-Hsin Shih, Fang-Hao Yeh, Yung-Nien Sun, Jung-Chih Chen, Po-Lin Chen, Hsien-Chang Chang
Gram-negative bacteria (GNBs) are common pathogens causing severe sepsis. Rapid evaluation of drug susceptibility would guide effective antibiotic treatment and promote life-saving. A total of 78 clinical isolates of 13 Gram-negative species collected between April 2013 and November 2013 from two medical centers in Tainan were tested. Bacterial morphology changes in different concentrations of antibiotics were observed under the electric field of a quadruple electrode array using light microscopy. The minimal inhibitory concentrations (MICs) of four antimicrobial agents, namely, cefazolin, ceftazidime, cefepime, and doripenem, were determined by the dielectrophoretic antimicrobial susceptibility testing (dAST) and by the conventional broth dilution testing (BDT)...
March 31, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28274128/-evaluation-of-a-new-immunochromatographic-kit-for-enhanced-detection-of-influenza-b-virus
#6
Yasushi Ashikawa, Yoshio Takasaki, Shizuo Shindo, Yuji Yamashita, Keigo Shibao, Takashi Yokoyama, Takato Yokoyama, Minako Iwaya, Yumi Kiyomatsu, Hiroshi Miyamoto
We have evaluated a new immunochromatographic kit, "KBM LineCheck Flu AB", which had been developed for enhanced detection of influenza B viruses. Five strains of influenza A and B viruses were tested for reactivity and detection limits of the kit. Compared with the detection limits of commercially available kit of QuickNavi-Flu, "KBM LineCheck Flu AB" showed a nearly equal reactivity to influenza A viruses, but quadruple reactivity to 2 influenza B viruses. Also, "KBM LineCheck Flu AB" exhibited high specificity when tested in 130 influenza-negative culture specimens derived from 24 adult volunteers...
March 22, 2017: JARMAM: Journal of the Association for Rapid Method and Automation in Microbiology
https://www.readbyqxmd.com/read/28146302/simultaneous-determination-of-eight-bioactive-components-of-qishen-yiqi-dripping-pills-in-rat-plasma-using-uflc-ms-ms-and-its-application-to-a-pharmacokinetic-study
#7
Yaping Shao, Wen Zhang, Ling Tong, Jingyi Huang, Dongxiang Li, Wei Nie, Yan Zhu, Yunfei Li, Tao Lu
In this study, a rapid and reliable ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method was developed and validated for the simultaneous determination of eight active ingredients, including astragaloside IV (AIV), ononin (ONO), tanshinol (TSL), protocatechualdehyde (PCA), protocatechuic acid (PA), salvianolic acid D (SAD), rosmarinic acid (RA), and ginsenoside Rg1 (GRg1 ), in rat plasma. The plasma samples were pretreated by protein precipitation with acetonitrile. Chromatographic separation was performed on a Waters Acquity UPLC® BEH C18 column (1...
February 1, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28128346/a-lin28-homologue-reprograms-differentiated-cells-to-stem-cells-in-the-moss-physcomitrella-patens
#8
Chen Li, Yusuke Sako, Akihiro Imai, Tomoaki Nishiyama, Kari Thompson, Minoru Kubo, Yuji Hiwatashi, Yukiko Kabeya, Dale Karlson, Shu-Hsing Wu, Masaki Ishikawa, Takashi Murata, Philip N Benfey, Yoshikatsu Sato, Yosuke Tamada, Mitsuyasu Hasebe
Both land plants and metazoa have the capacity to reprogram differentiated cells to stem cells. Here we show that the moss Physcomitrella patens Cold-Shock Domain Protein 1 (PpCSP1) regulates reprogramming of differentiated leaf cells to chloronema apical stem cells and shares conserved domains with the induced pluripotent stem cell factor Lin28 in mammals. PpCSP1 accumulates in the reprogramming cells and is maintained throughout the reprogramming process and in the resultant stem cells. Expression of PpCSP1 is negatively regulated by its 3'-untranslated region (3'-UTR)...
January 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28009931/do-more-robust-prescription-drug-monitoring-programs-reduce-prescription-opioid-overdose
#9
Bryce Pardo
BACKGROUND AND AIMS: In the United States, overdose deaths attributed to opioid pain relievers (OPR) have quadrupled since 1999, prompting many states to adopt Prescription Drug Monitoring Programs (PMP). This study aimed to: (1) estimate the relationship of PMP strength with OPR overdose deaths across states and over time; (2) measure what threshold in PMP strength is associated with the greatest reduction in OPR overdose; and (3) assess the relationship of medical marijuana dispensaries with OPR overdose deaths...
December 23, 2016: Addiction
https://www.readbyqxmd.com/read/27871759/rabbit-atg-or-basiliximab-induction-for-rapid-steroid-withdrawal-after-renal-transplantation-harmony-an-open-label-multicentre-randomised-controlled-trial
#10
Oliver Thomusch, Michael Wiesener, Mirian Opgenoorth, Andreas Pascher, Rainer Peter Woitas, Oliver Witzke, Bernd Jaenigen, Markus Rentsch, Heiner Wolters, Thomas Rath, Tülay Cingöz, Urs Benck, Bernhard Banas, Christian Hugo
BACKGROUND: Standard practice for immunosuppressive therapy after renal transplantation is quadruple therapy using antibody induction, low-dose tacrolimus, mycophenolate mofetil, and corticosteroids. Long-term steroid intake significantly increases cardiovascular risk factors with negative effects on the outcome, especially post-transplantation diabetes associated with morbidity and mortality. In this trial, we examined the efficacy and safety parameters of rapid steroid withdrawal after induction therapy with either rabbit antithymocyte globulin (rabbit ATG) or basiliximab in immunologically low-risk patients during the first year after kidney transplantation...
December 17, 2016: Lancet
https://www.readbyqxmd.com/read/27758895/epidermal-phytochrome-b-inhibits-hypocotyl-negative-gravitropism-non-cell-autonomously
#11
Jaewook Kim, Kijong Song, Eunae Park, Keunhwa Kim, Gabyong Bae, Giltsu Choi
Seedling hypocotyls display negative gravitropism in the dark but agravitropism in the light. The Arabidopsis thaliana pif quadruple mutant (pifQ), which lacks four PHYTOCHROME-INTERACTING FACTORS (PIFs), is agravitropic in the dark. Endodermis-specific expression of PIF1 rescues gravitropism in pifQ mutant seedlings. Since phytochromes induce light responses by inhibiting PIFs and the COP1-SPA ubiquitin E3 ligase complex in the nucleus, we asked whether phyB can cell autonomously inhibit hypocotyl negative gravitropism in the endodermis...
November 2016: Plant Cell
https://www.readbyqxmd.com/read/27732924/aplication-of-the-statistical-experimental-design-to-optimize-mine-impacted-water-miw-remediation-using-shrimp-shell
#12
Dámaris Núñez-Gómez, Alcione Aparecida de Almeida Alves, Flavio Rubens Lapolli, María A Lobo-Recio
Mine-impacted water (MIW) is one of the most serious mining problems and has a high negative impact on water resources and aquatic life. The main characteristics of MIW are a low pH (between 2 and 4) and high concentrations of SO4(2-) and metal ions (Cd, Cu, Ni, Pb, Zn, Fe, Al, Cr, Mn, Mg, etc.), many of which are toxic to ecosystems and human life. Shrimp shell was selected as a MIW treatment agent because it is a low-cost metal-sorbent biopolymer with a high chitin content and contains calcium carbonate, an acid-neutralizing agent...
January 2017: Chemosphere
https://www.readbyqxmd.com/read/27725895/breast-cancer-molecular-subtypes-from-tnbc-to-qnbc
#13
REVIEW
Jane Date C Hon, Baljit Singh, Aysegul Sahin, Gang Du, Jinhua Wang, Vincent Y Wang, Fang-Ming Deng, David Y Zhang, Marie E Monaco, Peng Lee
Treatment protocols for breast cancer depend predominantly on receptor status with respect to estrogen (estrogen receptor alpha), progesterone (progesterone receptor) and human epidermal growth factor [human epidermal growth factor receptor 2 (HER2)]. The presence of one or more of these receptors suggests that a treatment targeting these pathways might be effective, while the absence of, or in the case of HER2, lack of overexpression of, all of these receptors, termed triple negative breast cancer (TNBC), indicates a need for the more toxic chemotherapy...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27723640/antimicrobial-efficacy-of-the-combinations-of-acacia-nilotica-murrayakoenigii-linn-sprengel-eucalyptus-and-psidiumguajava-on-primary-plaque-colonizers-an-in-vitro-study
#14
Byalakere Rudraiah Chandra Shekar, Ramesh Nagarajappa, Rupal Singh, S Suma, Rupesh Thakur
BACKGROUND: The rise in disease incidence, increased resistance of pathogenic bacteria to currently used antibiotics and chemotherapeutics, opportunistic infections in immunocompromised individuals, and financial considerations in developing countries necessitates alternate preventive and treatment strategies for oral diseases. OBJECTIVE: The objective of the study is to assess the antimicrobial efficacy of triple and quadruple combinations of Acacia nilotica (AN), Murraya koenigii (Linn...
July 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/27627591/performance-of-prenatal-screening-using-maternal-serum-and-ultrasound-markers-for-down-syndrome-in-chinese-women-a-systematic-review-and-meta-analysis
#15
REVIEW
S Tu, M Rosenthal, D Wang, J Huang, Y Chen
BACKGROUND: Controversies about the performance of conventional prenatal screening using maternal serum and ultrasound markers (PSMSUM) in detecting Down syndrome (DS) have been raised as a result of a recently available noninvasive prenatal test based on cell-free fetal DNA sequencing. OBJECTIVES: To evaluate the screening performance of PSMSUM in detecting DS in Chinese women. SEARCH STRATEGY: An exhaustive literature search of MEDLINE, Embase, the Cochrane Library, ISI Web of Science and China BioMedical Disc...
September 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27599431/comparing-nucleic-acid-lateral-flow-and-electrochemical-genosensing-for-the-simultaneous-detection-of-foodborne-pathogens
#16
A Ben Aissa, J J Jara, R M Sebastián, A Vallribera, S Campoy, M I Pividori
Due to the increasing need of rapid tests for application in low resource settings, WHO summarized their ideal features under the acronym ASSURED (Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, Delivered to those who need it). In this work, two different platforms for the rapid and simultaneous testing of the foodborne pathogens E. coli O157:H7 and Salmonella enterica, in detail a nucleic acid lateral flow and an electrochemical magneto-genosensor are presented and compared in terms of their analytical performance...
February 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27591813/pif1-regulates-plastid-development-by-repressing-photosynthetic-genes-in-the-endodermis
#17
Keunhwa Kim, Jinkil Jeong, Jeongheon Kim, Nayoung Lee, Mi Eon Kim, Sangil Lee, Sun Chang Kim, Giltsu Choi
Mutations in Phytochrome Interacting Factors (PIFs) induce a conversion of the endodermal amyloplasts necessary for gravity sensing to plastids with developed thylakoids accompanied by abnormal activation of photosynthetic genes in the dark. In this study, we investigated how PIFs regulate endodermal plastid development by performing comparative transcriptome analysis. We show that both endodermal expression of PIF1 and global expression of the PIF quartet induce transcriptional changes in genes enriched for nuclear-encoded photosynthetic genes such as LHCA and LHCB...
October 10, 2016: Molecular Plant
https://www.readbyqxmd.com/read/27504954/evaluation-of-a-urine-pooling-strategy-for-the-rapid-and-cost-efficient-prevalence-classification-of-schistosomiasis
#18
Nathan C Lo, Jean T Coulibaly, Eran Bendavid, Eliézer K N'Goran, Jürg Utzinger, Jennifer Keiser, Isaac I Bogoch, Jason R Andrews
BACKGROUND: A key epidemiologic feature of schistosomiasis is its focal distribution, which has important implications for the spatial targeting of preventive chemotherapy programs. We evaluated the diagnostic accuracy of a urine pooling strategy using a point-of-care circulating cathodic antigen (POC-CCA) cassette test for detection of Schistosoma mansoni, and employed simulation modeling to test the classification accuracy and efficiency of this strategy in determining where preventive chemotherapy is needed in low-endemicity settings...
August 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27490936/determination-of-ginkgolides-a-b-c-j-and-bilobalide-in-plasma-by-lc-esi-ms-ms-qqq-and-its-application-to-the-pharmacokinetic-study-of-ginkgo-biloba-extract-in-rats
#19
Z Yan-Yan, G Li-Li, S Guo-Ming, R Rong, T Jing-Zhen
A simple, rapid, and specific high-performance liquid chromatograph coupled with a tandem mass spectrometry method has been developed and validated for the quantification of ginkgolides in rat plasma, and the main pharmacokinetic parameters of ginkgolides after oral administration of Ginkgo biloba extract (GBE) was acquired. Methods: Plasma samples were pretreated with ethyl acetate extraction. Sulfamethoxazole was used as the internal standard (IS). Chromatographic separation was achieved on an Eclipse XDB-C18 column (2...
October 2016: Drug Research
https://www.readbyqxmd.com/read/27390349/quadruple-negative-gist-is-a-sentinel-for-unrecognized-neurofibromatosis-type-1-syndrome
#20
Daniela Gasparotto, Sabrina Rossi, Maurizio Polano, Elena Tamborini, Erica Lorenzetto, Marta Sbaraglia, Alessia Mondello, Marco Massani, Stefano Lamon, Raffaella Bracci, Alessandra Mandolesi, Elisabetta Frate, Franco Stanzial, Jerin Agaj, Guido Mazzoleni, Silvana Pilotti, Alessandro Gronchi, Angelo Paolo Dei Tos, Roberta Maestro
PURPOSE: The majority of gastrointestinal stromal tumors (GIST) are driven by KIT, PDGFRA, or, less commonly, BRAF mutations, and SDH gene inactivation is involved in a limited fraction of gastric lesions. However, about 10% of GISTs are devoid of any of such alterations and are poorly responsive to standard treatments. This study aims to shed light on the molecular drivers of quadruple-negative GISTs. EXPERIMENTAL DESIGN: Twenty-two sporadic quadruple-negative GISTs with no prior association with Neurofibromatosis Type 1 syndrome were molecularly profiled for a panel of genes belonging to tyrosine kinase pathways or previously implicated in GISTs...
January 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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