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Quadruple negative

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https://www.readbyqxmd.com/read/29722530/high-pressure-synthesis-structures-and-properties-of-trivalent-a-site-ordered-quadruple-perovskites-rmn-7-o-12-r-sm-eu-gd-and-tb
#1
Lei Zhang, Noriki Terada, Roger D Johnson, Dmitry D Khalyavin, Pascal Manuel, Yoshio Katsuya, Masahiko Tanaka, Yoshitaka Matsushita, Kazunari Yamaura, Alexei A Belik
A-site-ordered quadruple perovskites RMn7 O12 with R = Sm, Eu, Gd, and Tb were synthesized at high pressure and high temperature (6 GPa and ∼1570 K), and their structural, magnetic, and dielectric properties are reported. They crystallize in space group I2/ m at room temperature. All four compounds exhibit a high-temperature phase transition to the cubic Im3̅ structure at ∼664 K (Sm), 663 K (Eu), 657 K (Gd), and 630 K (Tb). They all show one magnetic transition at TN1 ≈ 82-87 K at zero magnetic field, but additional magnetic transitions below TN2 ≈ 12 K were observed in SmMn7 O12 and EuMn7 O12 at high magnetic fields...
May 3, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29650479/core-shell-indium-iii-sulfide-metal-organic-framework-nanocomposite-as-an-adsorbent-for-the-dispersive-solid-phase-extraction-of-nitro-polycyclic-aromatic-hydrocarbons
#2
Yuqian Jia, Yanfang Zhao, Mei Zhao, Zhenhua Wang, Xiangfeng Chen, Minglin Wang
A core-shell discoid shaped indium (III) sulfide@metal-organic framework (MIL-125(Ti)) nanocomposite was synthesized by a solvothermal method and explored as an adsorbent material for dispersive solid-phase extraction (d-SPE). The as-synthesized sorbent was characterized by scanning electron microscopy, energy-dispersive spectroscopy, transmission electron microscopy, powder X-ray diffraction, N2 adsorption-desorption analysis, and Fourier transform infrared spectroscopy. The extraction performance was evaluated by the d-SPE of 16 nitro-polycyclic aromatic hydrocarbons (NPAHs) from water samples...
April 5, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29609070/equivalent-efficacies-of-reverse-hybrid-and-bismuth-quadruple-therapies-in-eradication-of-helicobacter-pylori-infection-in-a-randomized-controlled-trial
#3
Ping-I Hsu, Feng-Woei Tsay, David Y Graham, Tzung-Jiun Tsai, Kuo-Wang Tsai, John Y Kao, Nan-Jing Peng, Chao-Hung Kuo, Sung-Shuo Kao, Huay-Min Wang, Te-Fu Lin, Deng-Chyang Wu
BACKGROUND & AIMS: Bismuth quadruple therapy is recommended as a first-line treatment for Helicobacter pylori infection in the United States but hybrid therapy is an alternative option. Reverse hybrid therapy (proton pump inhibitor plus amoxicillin for 14 days, and clarithromycin plus metronidazole for the initial 7 days) is a simplified hybrid treatment. We aimed to assess the efficacies of reverse hybrid therapy vs bismuth quadruple therapy as first-line treatments for patients with H pylori infection in a randomized trial...
March 30, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29600266/clinical-outcome-of-anatomical-transportal-arthroscopic-anterior-cruciate-ligament-reconstruction-with-hamstring-tendon-autograft
#4
Omid Shahpari, Moslem FallahKezabi, Hamid Hejrati Kalati, Farshid Bagheri, Mohammad H Ebrahimzadeh
Background: Good clinical outcome and return to sport and daily functions after anatomical arthroscopic anterior cruciate ligament (ACL) reconstruction is goal standard in this surgery. but to date, there are different challenging issues between orthopedic surgeons regarding graft selection and surgical techniques. Methods: We retrospectively reviewed the patients who underwent anatomical arthroscopic one bundle ACL reconstruction with quadruple hamstring tendon autograft from 2010 to 2016 in our orthopedic sport medicine center...
March 2018: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29596646/new-single-capsule-of-bismuth-metronidazole-and-tetracycline-given-with-omeprazole-versus-quadruple-therapy-consisting-of-bismuth-omeprazole-amoxicillin-and-clarithromycin-for-eradication-of-helicobacter-pylori-in-duodenal-ulcer-patients-a-chinese-prospective
#5
Yong Xie, Xiaolin Pan, Yan Li, Huahong Wang, Yiqi Du, Jianming Xu, Jiangbin Wang, Zhirong Zeng, Ye Chen, Guoxin Zhang, Kaichun Wu, Dongsheng Liu, Nonghua Lv
Objectives: To assess the efficacy and safety of omeprazole given with the new single capsule of bismuth, metronidazole and tetracycline (OBMT) compared with quadruple treatment consisting of omeprazole, bismuth, amoxicillin and clarithromycin (OBAC) for Helicobacter pylori eradication in duodenal ulcer patients. Methods: This single-blind, randomized multicentre trial was conducted in 10 tertiary hospitals in China between January 2013 and April 2014. Patients were randomized to receive 10 days of OBMT therapy or 10 days of OBAC therapy...
March 27, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29581511/a-group-of-receptor-kinases-are-essential-for-clavata-signalling-to-maintain-stem-cell-homeostasis
#6
Chong Hu, Yafen Zhu, Yanwei Cui, Kaili Cheng, Wan Liang, Zhuoyun Wei, Mingsong Zhu, Hongju Yin, Li Zeng, Ya Xiao, Minghui Lv, Jing Yi, Suiwen Hou, Kai He, Jia Li, Xiaoping Gou
Continuous organ initiation and outgrowth in plants relies on the proliferation and differentiation of stem cells maintained by the CLAVATA (CLV)-WUSCHEL (WUS) negative-feedback loop1-3 . Leucine-rich repeat receptor-like protein kinases (LRR-RLKs), including CLV1, BARELY ANY MERISTEMS and RECEPTOR-LIKE PROTEIN KINASE 2 (RPK2), a receptor-like protein CLV2 and a pseudokinase CORYNE (CRN) are involved in the perception of the CLV3 signal to repress WUS expression4-10 . WUS, a homeodomain transcription factor, in turn directly activates CLV3 expression and promotes stem cell activity in the shoot apical meristem11,12 ...
April 2018: Nature Plants
https://www.readbyqxmd.com/read/29576645/anterior-cruciate-ligament-reconstruction-with-tibial-attachment-preserving-hamstring-graft-without-implant-on-tibial-side
#7
Skand Sinha, Ananta Kumar Naik, Mridul Maheshwari, Sumedh Sandanshiv, Durgashankar Meena, Rajendra K Arya
Background: Tibial attachment preserving hamstring graft could prevent potential problems of free graft in anterior cruciate ligament (ACL) reconstruction such as pull out before graft-tunnel healing or rupture before ligamentization. Different implants have been reportedly used for tibial side fixation with this technique. We investigated short-term outcome of ACL reconstruction (ACLR) with tibial attachment sparing hamstring graft without implant on the tibial side by outside in technique...
March 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29569327/reducing-emergency-room-visits-and-in-hospitalizations-by-implementing-best-practice-for-transitional-care-using-innovative-technology-and-big-data
#8
Sharon Hewner, Suzanne S Sullivan, Guan Yu
BACKGROUND: Efforts to improve care transitions require coordination across the healthcare continuum and interventions that enhance communication between acute and community settings. AIMS: To improve post-discharge utilization value using technology to identify high-risk individuals who might benefit from rapid nurse outreach to assess social and behavioral determinants of health with the goal of reducing inpatient and emergency department visits. METHODS: The project employed a before and after comparison of the intervention site with similar primary care practice sites using population-level Medicaid claims data...
March 23, 2018: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/29396076/-what-are-the-real-purpose-and-scope-of-screening-for-aneuploidy
#9
T Quibel, P Rozenberg
In France, the recommended method for Down syndrome screening is the first trimester combined test, the risk assessment, based on maternal age, ultrasound measurement of fetal nuchal translucency and maternal serum markers (free β-hCG and PAPP-A). The Down syndrome detection rate is 78.7% at a screen positive rate of 5%. However, the best screening test is the integrated test using a combination of first trimester combined test and second trimester quadruple test (serum α-fetoprotein, human chorionic gonadotropin, unconjugated E3 , and dimeric inhibin-A) and being able to achieve a detection rate for Down syndrome of approximately 96% at a screen-positive rate of 5%...
February 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29340907/harnessing-a-different-dependency-how-to-identify-and-target-androgen-receptor-positive-versus-quadruple-negative-breast-cancer
#10
REVIEW
Jessica L Christenson, Jane B Trepel, Haythem Y Ali, Sunmin Lee, Joel R Eisner, Edwina S Baskin-Bey, Anthony D Elias, Jennifer K Richer
The androgen receptor (AR) is a promising therapeutic target for a subset of triple-negative breast cancers (TNBCs) in which AR is expressed. However, the mechanistic action of AR and the degree to which primary and metastatic tumors depend on AR, both before and after conventional treatment, remain to be defined. We discuss preclinical and clinical data for AR+ TNBC, the difficulties in monitoring AR protein levels, new methods for determining AR status, the influence of AR on "stemness" in the context of TNBC, the role of combined inhibition of sex steroid production and AR, and the role of AR in regulation of the immune system...
January 16, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29298370/eradication-rate-of-helicobacter-pylori-on-the-us-mexico-border-using-the-urea-breath-test
#11
COMPARATIVE STUDY
Roy P Liu, Roberta Romero, Jerzy Sarosiek, Christopher Dodoo, Alok K Dwivedi, Marc J Zuckerman
OBJECTIVES: Helicobacter pylori is prevalent worldwide, especially in Latin America. Triple and quadruple antibiotic therapies have been relatively effective; however, resistance has emerged in recent years. The treatment success rate of these regimens on the border of the United States and Mexico is unknown. Our study attempted to determine eradication rates of two major regimens based on urea breath test (UBT) results in patients previously diagnosed as having H. pylori in a single center in El Paso, Texas, a city on the geographic border with Mexico...
January 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29274960/bacterial-diversity-and-composition-of-alfalfa-silage-as-analyzed-by-illumina-miseq-sequencing-effects-of-escherichia-coli-o157-h7-and-silage-additives
#12
I M Ogunade, Y Jiang, A A Pech Cervantes, D H Kim, A S Oliveira, D Vyas, Z G Weinberg, K C Jeong, A T Adesogan
The first objective of this study was to examine effects of adding Escherichia coli O157:H7 with or without chemical or microbial additives on the bacterial diversity and composition of alfalfa silage. The second objective was to examine associations between the relative abundance of known and unknown bacterial species and indices of silage fermentation quality. Alfalfa forage was harvested at 54% dry matter, chopped to a theoretical length of cut of 19 mm, and ensiled in quadruplicate in laboratory silos for 100 d after the following treatments were applied: (1) distilled water (control); (2) 1 × 105 cfu/g of E...
March 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29243877/multiple-sulfur-isotope-constraints-on-microbial-sulfate-reduction-below-an-archean-seafloor-hydrothermal-system
#13
Shinnosuke Aoyama, Yuichiro Ueno
Microbial sulfate reduction is among the most ubiquitous metabolic processes on earth. The oldest evidence of microbial sulfate reduction appears in the ca. 3.5 Ga Dresser Formation in the North Pole area of Pilbara Craton in Western Australia. That evidence was found through analysis of quadruple sulfur isotopes of sulfate and sulfide minerals deposited on the seafloor. However, the activity of microbial sulfate reduction below the Archean seafloor remains poorly understood. Here, we report the quadruple sulfur isotopic compositions of sulfide minerals within hydrothermally altered seafloor basalt and less altered basaltic komatiite collected from the North Pole Dome area...
March 2018: Geobiology
https://www.readbyqxmd.com/read/29164072/a-new-strain-collection-for-improved-expression-of-outer-membrane-proteins
#14
Ina Meuskens, Marcin Michalik, Nandini Chauhan, Dirk Linke, Jack C Leo
Almost all integral membrane proteins found in the outer membranes of Gram-negative bacteria belong to the transmembrane β-barrel family. These proteins are not only important for nutrient uptake and homeostasis, but are also involved in such processes as adhesion, protein secretion, biofilm formation, and virulence. As surface exposed molecules, outer membrane β-barrel proteins are also potential drug and vaccine targets. High production levels of heterologously expressed proteins are desirable for biochemical and especially structural studies, but over-expression and subsequent purification of membrane proteins, including outer membrane proteins, can be challenging...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29109183/mutation-and-suppressor-analysis-of-the-essential-lipopolysaccharide-transport-protein-lpta-reveals-strategies-to-overcome-severe-outer-membrane-permeability-defects-in-escherichia-coli
#15
Federica A Falchi, Elisa A Maccagni, Simone Puccio, Clelia Peano, Cristina De Castro, Angelo Palmigiano, Domenico Garozzo, Alessandra M Martorana, Alessandra Polissi, Gianni Dehò, Paola Sperandeo
In Gram-negative bacteria, lipopolysaccharide (LPS) contributes to the robust permeability barrier of the outer membrane (OM), preventing the entry of toxic molecules, such as detergents and antibiotics. LPS is transported from the inner membrane (IM) to the OM by the Lpt multiprotein machinery. Defects in LPS transport compromise LPS assembly at the OM and result in increased antibiotic sensitivity. LptA is a key component of the Lpt machine that interacts with the IM protein LptC and chaperones LPS through the periplasm...
January 15, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29062634/septic-shock-following-prostate-biopsy-aggressive-limb-salvage-for-extremities-after-pressor-induced-ischemic-gangrene
#16
Jocelyn Lu, Tammer Elmarsafi, Chrisovalantis Lakhiani, Sarah R Sher, Christopher Attinger, Karen K Evans
Vasopressors used to treat patients with septic shock can cause ischemic necrosis of appendages such as the ears and nose, as well as the extremities. Cases of quadruple-extremity necrosis have high morbidity and mortality, and a profound negative impact on quality of life. This case report details the successful limb salvage and return to function using free tissue transfer as a means to salvage bilateral lower extremities in a patient who suffered vasopressor-induced ischemia of upper and lower extremities after prostate biopsy-induced septic shock...
September 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29036509/medication-usage-change-in-older-people-65-in-england-over-20-years-findings-from-cfas-i-and-cfas-ii
#17
Lu Gao, Ian Maidment, Fiona E Matthews, Louise Robinson, Carol Brayne
Background: medical practice has changed over the last decades reflecting the ageing population, when multi-morbidity requiring multiple medications is more common. Objective: describe and quantify self-reported medicine use including both prescription and over the counter medicines in two comparable population-based studies of older people (65+) in England and to assess the nature and scale of polypharmacy. Methods: data used were from two separate population-based studies; the Cognitive Function Ageing Study I and II...
March 1, 2018: Age and Ageing
https://www.readbyqxmd.com/read/28957341/efficacy-and-safety-of-sequential-versus-quadruple-therapy-as-second-line-treatment-for-helicobacter-pylori-infection-a-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Daniela Munteanu, Ohad Etzion, Gil Ben-Yakov, Daniel Halperin, Leslie Eidelman, Doron Schwartz, Victor Novack, Naim Abufreha, Pavel Krugliak, Alexander Rozenthal, Nava Gaspar, Alexander Moshkalo, Vitaly Dizingof, Alexander Fich
BACKGROUND AND AIMS: Quadruple therapy is recommended as second-line treatment for Helicobacter pylori eradication failure. However, high cost, multiple side effects, and low adherence rates are major drawbacks to its routine use. Our aim was to compare the efficacy and safety of sequential versus quadruple regimens as second line treatment for persistent Helicobacter pylori infection. METHODS: Prospective, randomized, open label trial was conducted at a large academic, tertiary care center in Israel...
2017: PloS One
https://www.readbyqxmd.com/read/28877572/safety-efficacy-and-physicochemical-characterization-of-tinospora-crispa-ointment-a-community-based-formulation-against-pediculus-humanus-capitis
#19
Gerwin Louis Tapan Dela Torre, Kerstin Mariae Gonzales Ponsaran, Angelica Louise Dela Peña de Guzman, Richelle Ann Mallapre Manalo, Erna Custodio Arollado
The high prevalence of pediculosis capitis, commonly known as head lice (Pediculus humanus capitis) infestation, has led to the preparation of a community-based pediculicidal ointment, which is made of common household items and the extract of Tinospora crispa stem. The present study aimed to evaluate the safety, efficacy, and physicochemical characteristics of the T. crispa pediculicidal ointment. The physicochemical properties of the ointment were characterized, and safety was determined using acute dermal irritation test (OECD 404), while the efficacy was assessed using an in vitro pediculicidal assay...
August 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28861689/superactive-human-leptin-antagonist-shla-triple-lan1-and-quadruple-lan2-leptin-mutein-as-a-promising-treatment-for-human-folliculoma
#20
E Fiedor, E L Gregoraszczuk
PURPOSE: There are no data showing a direct correlation between obesity and increased blood leptin levels with folliculoma. Moreover, folliculoma is not the best studied among other ovarian cancer types. We investigated whether oestradiol can modulate ObR expression in some oestrogen-responsive tissues and that leptin exerts its activity not only via the leptin receptor but also through cross talk with other signalling systems. We hypothesise that blocking ObR expression could be a novel treatment for gonadal ovarian cancer...
October 2017: Cancer Chemotherapy and Pharmacology
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