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https://www.readbyqxmd.com/read/29332926/differentiating-between-alzheimer-disease-patients-and-controls-with-phase-difference-enhanced-imaging-at-3t-a-feasibility-study
#1
Machiko Tateishi, Mika Kitajima, Toshinori Hirai, Tetsuya Yoneda, Mamoru Hashimoto, Nan Kurehana, Hiroyuki Uetani, Ryuji Fukuhara, Minako Azuma, Yasuyuki Yamashita
PURPOSE: To test the feasibility of the phase difference enhanced (PADRE) imaging for differentiation between Alzheimer disease (AD) patients and control subjects on 3T MR imaging. MATERIALS AND METHODS: Fifteen patients with AD and 10 age-matched control subjects underwent two-dimensional fast field echo imaging to obtain PADRE images on a 3T MR scanner. A double Gaussian distribution model was used to determine the threshold phase value for differentiation between the physiologic and non-physiologic iron in the cerebral cortices, and PADRE images were processed with the threshold...
January 15, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29329014/nanoadsorbents-based-on-conducting-polymer-nanocomposites-with-main-focus-on-polyaniline-and-its-derivatives-for-removal-of-heavy-metal-ions-dyes-a-review
#2
REVIEW
Ehsan Nazarzadeh Zare, Ahmad Motahari, Mika Sillanpää
Water contamination by toxic heavy metal ions and dyes remains a serious public health problem for humans, so attention on specific methods and technologies to remove heavy metal ions and dyes from wastewaters/aqueous solutions are desired. Numerous adsorbents have been reported for the removal of heavy metal ions/dyes from wastewaters/aqueous solutions. Polyaniline (PANI) and its derivatives, as conducting polymers, are good adsorbents to remove various kinds of heavy metal ions and dyes from wastewaters/aqueous solutions...
January 9, 2018: Environmental Research
https://www.readbyqxmd.com/read/29326972/aggressive-neuroendocrine-tumor-of-the-ovary-with-multiple-metastases-treated-with-everolimus-a-case-report
#3
Michiko Kaiho-Sakuma, Masafumi Toyoshima, Mika Watanabe, Asami Toki, Satomi Kameda, Takamichi Minato, Hitoshi Niikura, Nobuo Yaegashi
•Neuroendocrine tumors (NETs) frequently occur in the lungs or the gastrointestinal tract; they are uncommon in the ovary.•The mammalian target of rapamycin (mTOR) pathway has been reported as a treatment for advanced NETs.•We describe a patient with an aggressive primary ovarian NET, successfully treated with everolimus (an mTOR inhibitor).
February 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29325947/usefulness-of-oblique-coronal-ct-and-mri-imaging-in-the-endoscopic-endonasal-approach-to-treat-skull-base-lesions
#4
Shigetoshi Yano, Naoki Shinojima, Mika Kitajima, Hiroyuki Uetani, Takuichiro Hide, Akitake Mukasa
OBJECTIVE: This report examines the utility of the preoperative image to orientate the surgeon in the sphenoid sinus during an endoscopic endonasal transsphenoidal approach (ETSS). METHODS: ETSS was performed in 100 cases of sellar lesion and used to classify the sphenoid sinus septum shape. Preoperative CT and MRI scans were taken for two types of coronal imaging: conventional and oblique. Expected sphenoid sinus septum shape was compared with those from ETSS to estimate concordance...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29324778/genetic-diversity-and-recombination-of-enterovirus-g-strains-in-japanese-pigs-high-prevalence-of-strains-carrying-a-papain-like-cysteine-protease-sequence-in-the-enterovirus-g-population
#5
Shinobu Tsuchiaka, Yuki Naoi, Ryo Imai, Tsuneyuki Masuda, Mika Ito, Masataka Akagami, Yoshinao Ouchi, Kazuo Ishii, Shoichi Sakaguchi, Tsutomu Omatsu, Yukie Katayama, Mami Oba, Junsuke Shirai, Yuki Satani, Yasuhiro Takashima, Yuji Taniguchi, Masaki Takasu, Hiroo Madarame, Fujiko Sunaga, Hiroshi Aoki, Shinji Makino, Tetsuya Mizutani, Makoto Nagai
To study the genetic diversity of enterovirus G (EV-G) among Japanese pigs, metagenomics sequencing was performed on fecal samples from pigs with or without diarrhea, collected between 2014 and 2016. Fifty-nine EV-G sequences, which were >5,000 nucleotides long, were obtained. By complete VP1 sequence analysis, Japanese EV-G isolates were classified into G1 (17 strains), G2 (four strains), G3 (22 strains), G4 (two strains), G6 (two strains), G9 (six strains), G10 (five strains), and a new genotype (one strain)...
2018: PloS One
https://www.readbyqxmd.com/read/29324175/radiation-and-age-associated-changes-in-peripheral-blood-dendritic-cell-populations-among-aging-atomic-bomb-survivors-in-japan
#6
Junko Kajimura, Heather E Lynch, Susan Geyer, Benjamin French, Mika Yamaoka, Ivo D Shterev, Gregory D Sempowski, Seishi Kyoizumi, Kengo Yoshida, Munechika Misumi, Waka Ohishi, Tomonori Hayashi, Kei Nakachi, Yoichiro Kusunoki
Previous immunological studies in atomic bomb survivors have suggested that radiation exposure leads to long-lasting changes, similar to immunological aging observed in T-cell-adaptive immunity. However, to our knowledge, late effects of radiation on dendritic cells (DCs), the key coordinators for activation and differentiation of T cells, have not yet been investigated in humans. In the current study, we hypothesized that numerical and functional decreases would be observed in relationship to radiation dose in circulating conventional DCs (cDCs) and plasmacytoid DCs (pDCs) among 229 Japanese A-bomb survivors...
January 2018: Radiation Research
https://www.readbyqxmd.com/read/29323246/modulediscoverer-identification-of-regulatory-modules-in-protein-protein-interaction-networks
#7
Sebastian Vlaic, Theresia Conrad, Christian Tokarski-Schnelle, Mika Gustafsson, Uta Dahmen, Reinhard Guthke, Stefan Schuster
The identification of disease-associated modules based on protein-protein interaction networks (PPINs) and gene expression data has provided new insights into the mechanistic nature of diverse diseases. However, their identification is hampered by the detection of protein communities within large-scale, whole-genome PPINs. A presented successful strategy detects a PPIN's community structure based on the maximal clique enumeration problem (MCE), which is a non-deterministic polynomial time-hard problem. This renders the approach computationally challenging for large PPINs implying the need for new strategies...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319395/initial-report-of-sentinel-lymph-node-identification-during-laparoscopic-radical-hysterectomy-using-a-new-gamma-probe-technology
#8
Shinichi Togami, Toshihiko Kawamura, Mika Fukuda, Shintaro Yanazume, Masaki Kamio, Hiroaki Kobayashi
BACKGROUND: The standard surgical procedure for early-stage cervical cancer is abdominal radical hysterectomy, including pelvic lymphadenectomy. Currently, minimally invasive surgical techniques for early cervical cancer are progressing; total laparoscopic radical hysterectomy (TLRH) is a possible alternative to abdominal surgery. In addition, sentinel node navigation surgery (SNNS), which can prevent lower limb edema, has been widely used for radical hysterectomy. MATERIALS AND METHODS: A radioisotope is injected into the uterine cervix 1 day preoperatively and surgeons carefully identify the correct sentinel lymph nodes (SLNs) to prevent picking up the cervical gamma rays during surgery...
January 10, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29316447/circulating-metabolites-and-general-cognitive-ability-and-dementia-evidence-from-11-cohort-studies
#9
Sven J van der Lee, Charlotte E Teunissen, René Pool, Martin J Shipley, Alexander Teumer, Vincent Chouraki, Debora Melo van Lent, Juho Tynkkynen, Krista Fischer, Jussi Hernesniemi, Andres Metspalu, Archana Singh-Manoux, Aswin Verhoeven, Gonneke Willemsen, Francien A de Leeuw, Holger Wagner, Jenny van Dongen, Johannes Hertel, Kathrin Budde, Ko Willems van Dijk, Leonie Weinhold, M Arfan Ikram, Maik Pietzner, Markus Perola, Michael Wagner, Nele Friedrich, P E Slagboom, Philip Scheltens, Qiong Yang, Robert E Gertzen, Sarah Egert, Shuo Li, Thomas Hankemeier, Catharine E M van Beijsterveldt, Vasan Ramachandran, Wolfgang Maier, Carel F W Peeters, Hans Jörgen Grabe, Alfredo Ramirez, Sudha Seshadri, Toomas Haller, Mika Kivimäki, Veikko Salomaa, Ayşe Demirkan, Dorret Boomsma, Wiesje M van der Flier, Najaf Amin, Cornelia M van Duijn
INTRODUCTION: Identifying circulating metabolites that are associated with cognition and dementia may improve our understanding of the pathogenesis of dementia and provide crucial readouts for preventive and therapeutic interventions. METHODS: We studied 299 metabolites in relation to cognition (general cognitive ability) in two discovery cohorts (N total = 5658). Metabolites significantly associated with cognition after adjusting for multiple testing were replicated in four independent cohorts (N total = 6652), and the associations with dementia and Alzheimer's disease (N = 25,872) and lifestyle factors (N = 5168) were examined...
January 6, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29316371/asthma-and-atopic-dermatitis-after-early-late-and-post-term-birth
#10
Päivi Korhonen, Paula Haataja, Riitta Ojala, Mikko Hirvonen, Matti Korppi, Marita Paassilta, Jukka Uotila, Mika Gissler, Tiina Luukkaala, Outi Tammela
OBJECTIVE: To assess the incidence and risk factors of asthma and atopic dermatitis by seven years of age after early-term (ET) (37+0 -38+6 weeks), full-term (FT) (39+0 -40+6 weeks), late-term (LT) (41+0 -41+6 weeks), and especially post-term (PT) (≥42 weeks) birth. METHODS: Altogether, 965 203 infants born between 1991 and 2008 in Finland were investigated in ET, FT, LT, and PT groups. Data on asthma medication reimbursement and hospital visits for atopic dermatitis were retrieved from national health databases...
January 5, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29315585/ndrg2-deficiency-ameliorates-neurodegeneration-in-experimental-autoimmune-encephalomyelitis
#11
Thuong Manh Le, Mika Takarada-Iemata, Hieu Minh Ta, Jureepon Roboon, Hiroshi Ishii, Takashi Tamatani, Yasuko Kitao, Tsuyoshi Hattori, Osamu Hori
N-myc downstream-regulated gene 2 (NDRG2) is a differentiation- and stress-associated molecule that is predominantly expressed in astrocytes in the central nervous system. In this study, we examined the expression and role of NDRG2 in experimental autoimmune encephalomyelitis (EAE), which is an animal model of multiple sclerosis. Western blot and immunohistochemical analysis revealed that the expression of NDRG2 was observed in astrocytes of spinal cord, and was enhanced after EAE induction. A comparative analysis of wild-type (WT) and Ndrg2-/- mice revealed that deletion of Ndrg2 ameliorated the clinical symptoms of EAE...
January 6, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29315012/development-of-an-anti-her2-monoclonal-antibody-h2mab-139-against-colon-cancer
#12
Mika K Kaneko, Shinji Yamada, Shunsuke Itai, Yukinari Kato
Human epidermal growth factor receptor 2 (HER2) expression has been reported in several cancers, such as breast, gastric, lung, pancreatic, and colorectal cancers. HER2 is overexpressed in those cancers and is associated with poor clinical outcomes. Trastuzumab, a humanized anti-HER2 antibody, provides significant survival benefits for patients with HER2-overexpressing breast cancers and gastric cancers. In this study, we developed a novel anti-HER2 monoclonal antibody (mAb), H2Mab-139 (IgG1, kappa) and investigated it against colon cancers using flow cytometry, western blot, and immunohistochemical analyses...
January 9, 2018: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29311251/pulse-wave-velocity-predicts-the-progression-of-blood-pressure-and-development-of-hypertension-in-young-adults
#13
Teemu Koivistoinen, Leo-Pekka Lyytikäinen, Heikki Aatola, Tiina Luukkaala, Markus Juonala, Jorma Viikari, Terho Lehtimäki, Olli T Raitakari, Mika Kähönen, Nina Hutri-Kähönen
The aim of the present study was to examine whether pulse wave velocity (PWV) predicts the progression of blood pressure and the development of hypertension in young adults. In addition, we studied whether PWV improves the risk prediction of incident hypertension beyond traditional cardiovascular risk factors. Systolic and diastolic blood pressures were measured in 2007 and 2011 for 1449 Finnish adults (aged 30-45 years). In addition, PWV and other cardiovascular risk factors were measured in 2007. The association between PWV (in 2007) and blood pressure (in 2011) was studied in the whole population (n=1449) and in a normotensive subpopulation (n=1183)...
January 8, 2018: Hypertension
https://www.readbyqxmd.com/read/29306901/cardiometabolic-health-among-adult-offspring-of-hypertensive-pregnancies-the-cardiovascular-risk-in-young-finns-study
#14
Robyn J Tapp, Alun D Hughes, Mika Kähönen, Tien Yin Wong, Nicholas Witt, Terho Lehtimäki, Nina Hutri-Kähönen, Pinki Sahota, Markus Juonala, Olli T Raitakari
BACKGROUND: Cardiometabolic health among adult offspring of hypertensive disorders of pregnancy (HDP) is relatively unknown. We hypothesized that offspring of HDP would have abnormalities in the retinal microvasculature and cardiac structure by midadulthood. METHODS AND RESULTS: The Cardiovascular Risk in Young Finns Study included randomly selected children from 5 Finnish university cities. The mean age of participants was 40 years (range 34-49 years) at the time of retinal photography and cardiac assessment...
January 6, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29305980/predictive-performance-and-inter-laboratory-reproducibility-in-assessing-eye-irritation-potential-of-water-and-oil-soluble-mixtures-using-the-short-time-exposure-test-method
#15
Takayuki Abo, Allison Hilberer, Christine Behle-Wagner, Mika Watanabe, David Cameron, Annette Kirst, Yuko Nukada, Takuo Yuki, Daisuke Araki, Hitoshi Sakaguchi, Hiroshi Itagaki
The Short Time Exposure (STE) test method is an alternative method for assessing eye irritation potential using Statens Seruminstitut Rabbit Cornea cells and has been adopted as test guideline 491 by the Organisation for Economic Co-operation and Development. Its good predictive performance in identifying the Globally Harmonized System (GHS) No Category (NC) or Irritant Category has been demonstrated in evaluations of water-soluble substances, oil-soluble substances, and water-soluble mixtures. However, the predictive performance for oil-soluble mixtures was not evaluated...
January 3, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29303705/pneumonia-in-children-with-juvenile-idiopathic-arthritis-in-finland-1999-2014-a-nationwide-retrospective-register-linkage-study
#16
Päivi H Salonen, Hanna Säilä, Juha H Salonen, Miika Linna, Mika Helminen, Markku J Kauppi
OBJECTIVES: To compare the incidence of pneumonia in children with juvenile idiopathic arthritis (JIA) to the aged-matched general population and to evaluate the use of anti-rheumatic medication among children with JIA and pneumonia. METHODS: The National Hospital Discharge Register collects data on ICD-diagnoses of hospital patients in Finland. From this register, patients with JIA under 18 years of age with pneumonia from 1999 through 2014 were identified. The control group consisted of age-matched patients derived from the general population with a diagnosis of pneumonia made in the same calendar year as the pneumonia of the JIA patients...
December 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29301758/twenty-four-hour-urinary-potassium-excretion-but-not-sodium-excretion-is-associated-with-all-cause-mortality-in-a-general-population
#17
Yume Nohara-Shitama, Hisashi Adachi, Mika Enomoto, Ako Fukami, Eita Kumagai, Sachiko Nakamura, Shoko Kono, Nagisa Morikawa, Erika Nakao, Akiko Sakaue, Tomoko Tsuru, Yoshihiro Fukumoto
BACKGROUND: Few studies have examined the relationship between accurate monitoring of sodium or potassium consumption and mortality. We aimed to investigate the association between 24-hour urinary sodium or potassium excretion and ≈30-year mortality in a Japanese population using 24-hour urine collection. METHODS AND RESULTS: We enrolled a total of 1291 participants, aged 21 to 85 years, who underwent health checkups, including a blood test and 24-hour urine collection...
January 4, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29299381/the-m-7510t-c-mutation-hearing-impairment-and-a-complex-neurologic-phenotype
#18
Laura Kytövuori, Maria Gardberg, Kari Majamaa, Mika H Martikainen
Objectives: Mutations in mitochondrial DNA cause a variety of clinical phenotypes ranging from a mild hearing impairment (HI) to severe encephalomyopathy. The MT-TS1 gene is a hotspot for mutations causing HI. The m.7510T>C mutation in MT-TS1 has been previously associated with non-syndromic HI in four families from different ethnic backgrounds. Materials and Methods: We describe the clinical, genetic, and histopathological findings in a Finnish family with the heteroplasmic m...
December 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29298444/human-malformation-syndromes-of-defective-gli-opposite-phenotypes-of-2q14-2-gli2-and-7p14-2-gli3-microdeletions-and-a-glia-r-balance-model
#19
Yo Niida, Mika Inoue, Mamoru Ozaki, Etsuko Takase
GLI family zinc finger proteins are transcriptional effectors of the sonic hedgehog signaling pathway. GLI regulates gene expression and repression at various phases of embryonic morphogenesis. In humans, 4 GLI genes are known, and GLI2 (2q14.2) and GLI3 (7p14.1) mutations cause different syndromes. Here, we present 2 distinctive cases with a chromosomal microdeletion in one of these genes. Patient 1 is a 14-year-old girl with Culler-Jones syndrome. She manifested short stature, cleft palate, and mild intellectual/social disability caused by a 6...
January 4, 2018: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/29297103/long-term-pathological-gait-pattern-changes-after-talus-fractures-dynamic-measurements-with-a-new-insole
#20
Benedikt J Braun, Patrick Pelz, Nils T Veith, Mika Rollmann, Moritz Klein, Steven C Herath, Jörg H Holstein, Tim Pohlemann
PURPOSE: The aim of the current study was to describe long-term gait changes after talus fractures, identify patterns associated with poor outcome and discuss possible treatment options based on dynamic gait analysis. METHODS: Twenty-seven patients were followed-up clinically and via gait analysis after talus fracture osteosynthesis. Continuous dynamic pedobarography with a gait analysis insole was performed on a standardized parcours consisting of different gait tasks and matched to the outcome...
January 2, 2018: International Orthopaedics
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