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https://www.readbyqxmd.com/read/28732402/characteristics-of-black-carbon-in-snow-from-laohugou-no-12-glacier-on-the-northern-tibetan-plateau
#1
Yulan Zhang, Shichang Kang, Chaoliu Li, Tanguang Gao, Zhiyuan Cong, Michael Sprenger, Yajun Liu, Xiaofei Li, Junming Guo, Mika Sillanpää, Kun Wang, Jizu Chen, Yang Li, Shiwei Sun
Black carbon (BC) emitted from the incomplete combustion of biomass and fossil fuel impacts the climate system, cryospheric change, and human health. This study documents black carbon deposition in snow from a benchmark glacier on the northern Tibetan Plateau. Significant seasonality of BC concentrations indicates different input or post-depositional processes. BC particles deposited in snow had a mass volume median diameter slightly larger than that of black carbon particles typically found in the atmosphere...
July 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28725874/metabolites-of-alectinib-in-human-their-identification-and-pharmacological-activity
#2
Mika Sato-Nakai, Kosuke Kawashima, Toshito Nakagawa, Yukako Tachibana, Miyuki Yoshida, Kenji Takanashi, Peter N Morcos, Martin Binder, David J Moore, Li Yu
Two metabolites (M4 and M1b) in plasma and four metabolites (M4, M6, M1a and M1b) in faeces were detected through the human ADME study following a single oral administration of [(14)C]alectinib, a small-molecule anaplastic lymphoma kinase inhibitor, to healthy subjects. In the present study, M1a and M1b, which chemical structures had not been identified prior to the human ADME study, were identified as isomers of a carboxylate metabolite oxidatively cleaved at the morpholine ring. In faeces, M4 and M1b were the main metabolites, which shows that the biotransformation to M4 and M1b represents two main metabolic pathways for alectinib...
July 2017: Heliyon
https://www.readbyqxmd.com/read/28725316/post-prandial-plasma-glucose-less-than-or-equal-to-70-mg-dl-is-not-uncommon-in-young-japanese-women
#3
Ayaka Tsuboi, Mika Takeuchi, Kaori Kitaoka, Satomi Minato, Miki Kurata, Tsutomu Kazumi, Keisuke Fukuo
BACKGROUND: Post-breakfast/post-challenge plasma glucose (PG) concentrations were studied less in young normal weight Japanese women. We addressed these issues. METHODS: Two separate groups of female collegiate athletes and female untrained students underwent either a standardized meal test or a standard 75-g oral glucose tolerance test, but not both. Frequency of women whose post-breakfast/post-load PG fell to 70 mg/dL or lower (termed as low glycemia) was compared between athletes and non-athletes, who also underwent measurements of serum adipokines, markers of insulin resistance and inflammation and dual-energy X-ray absorptiometry...
August 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28725077/nationwide-studies-of-hematological-malignancies-in-inflammatory-bowel-disease
#4
Mitsunobu Matsushita, Norimasa Fukata, Mika Omiya, Kazuichi Okazaki
No abstract text is available yet for this article.
July 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28723802/tocilizumab-for-uncontrollable-systemic-inflammatory-response-syndrome-complicating-adult-onset-still-disease-case-report-and-review-of-literature
#5
Asami Masui-Ito, Ryuji Okamoto, Kaoru Ikejiri, Mika Fujimoto, Muneyoshi Tanimura, Shiro Nakamori, Tomohiro Murata, Eiji Ishikawa, Norikazu Yamada, Hiroshi Imai, Masaaki Ito
RATIONALE: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disease of unknown etiology characterized by evanescent salmon-pink rash, fever spikes, arthralgia, and lymphadenopathy. AOSD usually has a good prognosis, but it can sometimes be fatal, especially when it is complicated by systemic inflammatory response syndrome (SIRS) and multiple organ failure. PATIENT CONCERNS: A previously healthy 26-year-old woman was referred to our hospital for persistent high fever and mild systemic edema...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723521/bone-scan-index-and-progression-free-survival-data-for-progressive-metastatic-castration-resistant-prostate-cancer-patients-who-received-odm-201-in-the-arades-multicentre-study
#6
Mariana Reza, Robert Jones, John Aspegren, Christophe Massard, Leena Mattila, Mika Mustonen, Per Wollmer, Elin Trägårdh, Eva Bondesson, Lars Edenbrandt, Karim Fizazi, Anders Bjartell
BACKGROUND: ODM-201, a new-generation androgen receptor inhibitor, has shown clinical efficacy in prostate cancer (PCa). Quantitative methods are needed to accurately assess changes in bone as a measurement of treatment response. The Bone Scan Index (BSI) reflects the percentage of skeletal mass a given tumour affects. OBJECTIVE: To evaluate the predictive value of the BSI in metastatic castration-resistant PCa (mCRPC) patients undergoing treatment with ODM-201...
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28722830/ralfuranones-contribute-to-mushroom-type-biofilm-formation-by-ralstonia-solanacearum-strain-oe1-1
#7
Yuka Mori, Yuki Hosoi, Shiho Ishikawa, Kazusa Hayashi, Yu Asai, Hideyuki Ohnishi, Mika Shimatani, Kanako Inoue, Kenichi Ikeda, Hitoshi Nakayashiki, Yasuyo Nishimura, Kouhei Ohnishi, Akinori Kiba, Kenji Kai, Yasufumi Hikichi
After invasion into intercellular spaces of tomato plants, the soil-borne plant pathogenic Ralstonia solanacearum strain OE1-1 forms mushroom-shaped biofilms (mushroom-type biofilms, mBFs) on tomato cells, leading to its virulence. The strain OE1-1 produces aryl-furanone secondary metabolites, ralfuranones (A, B, J, K and L), dependent on the quorum sensing (QS) system with methyl 3-hydroxymyristate (3-OH MAME) synthesized by PhcB as a QS signal. Ralfuranones are associated with the feedback loop of the QS system...
July 19, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28719670/suppressive-effect-of-amp-activated-protein-kinase-on-the-epithelial-mesenchymal-transition-in-retinal-pigment-epithelial-cells
#8
Ryo Matoba, Yuki Morizane, Yusuke Shiode, Masayuki Hirano, Shinichiro Doi, Shinji Toshima, Ryoichi Araki, Mika Hosogi, Tomoko Yonezawa, Fumio Shiraga
The epithelial-mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells plays a central role in the development of proliferative vitreoretinopathy (PVR). The purpose of this study was to investigate the effect of AMP-activated protein kinase (AMPK), a key regulator of energy homeostasis, on the EMT in RPE cells. In this study, EMT-associated formation of cellular aggregates was induced by co-stimulation of cultured ARPE-19 cells with tumor necrosis factor (TNF)-α (10 ng/ml) and transforming growth factor (TGF)-β2 (5 ng/ml)...
2017: PloS One
https://www.readbyqxmd.com/read/28716217/comparison-of-all-19-published-prognostic-scores-for-intracerebral-hemorrhage
#9
Jarno Satopää, Satu Mustanoja, Atte Meretoja, Jukka Putaala, Markku Kaste, Mika Niemelä, Turgut Tatlisumak, Daniel Strbian
BACKGROUND AND AIMS: We evaluated the accuracy of 19 published prognostic scores to find the best tool for predicting mortality after intracerebral hemorrhage (ICH). METHODS: A retrospective single-center analysis of consecutive patients with ICH (n=1013). After excluding patients with missing data (n=131), we analyzed 882 patients for 3-month (primary outcome), in-hospital, and 12-month mortality. We analyzed the strength of the individual score components and calculated the c-statistics, Youden index, sensitivity, specificity, negative and positive predictive value (NPV and PPV) for the scores...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28716091/suppression-of-the-phytoene-synthase-gene-egcrtb-alters-carotenoid-content-and-intracellular-structure-of-euglena-gracilis
#10
Shota Kato, Mika Soshino, Shinichi Takaichi, Takahiro Ishikawa, Noriko Nagata, Masashi Asahina, Tomoko Shinomura
BACKGROUND: Photosynthetic organisms utilize carotenoids for photoprotection as well as light harvesting. Our previous study revealed that high-intensity light increases the expression of the gene for phytoene synthase (EgcrtB) in Euglena gracilis (a unicellular phytoflagellate), the encoded enzyme catalyzes the first committed step of the carotenoid biosynthesis pathway. To examine carotenoid synthesis of E. gracilis in response to light stress, we analyzed carotenoid species and content in cells grown under various light intensities...
July 17, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28715821/a-history-of-cow-s-milk-allergy-is-associated-with-lower-vitamin-d-status-in-schoolchildren
#11
Jenni Rosendahl, Mikael Fogelholm, Anna Pelkonen, Mika J Mäkelä, Outi Mäkitie, Maijaliisa Erkkola
BACKGROUND/AIMS: Vitamin D insufficiency is common in children. We aimed to evaluate the main determinants of vitamin D status in Finnish school-aged children, including the history of allergic diseases. METHODS: We conducted a cross-sectional study on 171 ten-year-olds where serum 25-hydroxyvitamin D (25[OH]D) levels were measured, and data on food consumption and use of vitamin D supplements were collected. The history of allergic diseases was evaluated with a validated questionnaire...
July 14, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28715279/crystal-structure-of-a-%C3%AE-fructofuranosidase-with-high-transfructosylation-activity-from-aspergillus-kawachii
#12
Mika Nagaya, Miyoko Kimura, Yoshifumi Gozu, Shona Sato, Katsuaki Hirano, Takumi Tochio, Atsushi Nishikawa, Takashi Tonozuka
β-Fructofuranosidases belonging to glycoside hydrolase family (GH) 32 are enzymes that hydrolyze sucrose. Some GH32 enzymes also catalyze transfructosylation to produce fructooligosaccharides. We found that Aspergillus kawachii IFO 4308 β-fructofuranosidase (AkFFase) produces fructooligosaccharides, mainly 1-kestose, from sucrose. We determined the crystal structure of AkFFase. AkFFase is composed of an N-terminal small component, a β-propeller catalytic domain, an α-helical linker, and a C-terminal β-sandwich, similar to other GH32 enzymes...
July 17, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28712708/discovery-of-novel-2-3-phenylpiperazin-1-yl-pyrimidin-4-ones-as-glycogen-synthase-kinase-3%C3%AE-inhibitors
#13
Yoshihiro Usui, Fumiaki Uehara, Shinsuke Hiki, Kazutoshi Watanabe, Hiroshi Tanaka, Aya Shouda, Satoshi Yokoshima, Keiichi Aritomo, Takashi Adachi, Kenji Fukunaga, Shinji Sunada, Mika Nabeno, Ken-Ichi Saito, Jun-Ichi Eguchi, Keiji Yamagami, Shouichi Asano, Shinji Tanaka, Satoshi Yuki, Narihiko Yoshii, Masatake Fujimura, Takashi Horikawa
We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GSK-3β inhibitors. SAR studies focused on the phenyl moiety revealed that a 4-fluoro-2-methoxy group afforded potent inhibitory activity toward GSK-3β. Based on docking studies, new hydrogen bonding between the nitrogen atom of the piperazine moiety and the oxygen atom of the main chain of Gln185 has been indicated, which may contribute to increased activity compared with that of the corresponding phenylmorpholine analogues...
July 5, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28712706/discovery-of-novel-2-4-aryl-2-methylpiperazin-1-yl-pyrimidin-4-ones-as-glycogen-synthase-kinase-3%C3%AE-inhibitors
#14
Toshiyuki Kohara, Kazuki Nakayama, Kazutoshi Watanabe, Shin-Ichi Kusaka, Daiki Sakai, Hiroshi Tanaka, Kenji Fukunaga, Shinji Sunada, Mika Nabeno, Ken-Ichi Saito, Jun-Ichi Eguchi, Akiko Mori, Shinji Tanaka, Tomoko Bessho, Keiko Takiguchi-Hayashi, Takashi Horikawa
We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 3-methylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GSK-3β inhibitors. SAR studies focused on the nitrogen atom of the piperazine moiety revealed that a phenyl group afforded potent inhibitory activity toward GSK-3β. Docking studies indicated that the phenyl group on the piperazine nitrogen atom and the methyl group on the piperazine make cation-π and CH-π interactions with GSK-3β respectively...
July 5, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28712430/social-networks-and-patterns-of-health-risk-behaviours-over-two-decades-a-multi-cohort-study
#15
Maarit Kauppi, Marko Elovainio, Sari Stenholm, Marianna Virtanen, Ville Aalto, Markku Koskenvuo, Mika Kivimäki, Jussi Vahtera
OBJECTIVE: To determine the associations between social network size and subsequent long-term health behaviour patterns, as indicated by alcohol use, smoking, and physical activity. METHODS: Repeat data from up to six surveys over a 15- or 20-year follow-up were drawn from the Finnish Public Sector study (Raisio-Turku cohort, n=986; Hospital cohort, n=7307), and the Health and Social Support study (n=20,115). Social network size was determined at baseline, and health risk behaviours were assessed using repeated data from baseline and follow-up...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28711735/transcranial-magnetic-stimulation-of-early-visual-cortex-suppresses-conscious-representations-in-a-dichotomous-manner-without-gradually-decreasing-their-precision
#16
Mika Koivisto, Inari Harjuniemi, Henry Railo, Niina Salminen-Vaparanta, Antti Revonsuo
Transcranial magnetic stimulation (TMS) of early visual cortex can suppresses visual perception at early stages of processing. The suppression can be measured both with objective forced-choice tasks and with subjective ratings of visual awareness, but there is lack of objective evidence on how and whether the TMS influences the quality of representations. Does TMS decrease the precision of representations in graded manner, or does it lead to dichotomous, "all-or-nothing" suppression. We resolved this question by using a continuous measure of the perceptual error: the observers had to perceive the orientation of a target (Landort-C) and to adjust the orientation of a probe to match that of the target...
July 12, 2017: NeuroImage
https://www.readbyqxmd.com/read/28710522/cta-analysis-and-assessment-of-morphological-factors-related-to-rupture-in-413-posterior-communicating-artery-aneurysms
#17
Justiina Huhtakangas, Martin Lehecka, Hanna Lehto, Behnam Rezai Jahromi, Mika Niemelä, Riku Kivisaari
Posterior communicating artery (PcomA) aneurysms are frequently encountered, but there are few publications on their morphology. A growing number of aneurysms are incidental findings, which makes evaluation of rupture risk important. Our goal was to identify morphological features and anatomical variants associated with PComA aneurysms and to assess parameters related to rupture. We studied CT angiographies of 391 consecutive patients treated between 2000 and 2014 at a single institution. We determined clinically important morphological parameters and performed univariate and multivariate analysis...
July 14, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28709369/deposition-and-light-absorption-characteristics-of-precipitation-dissolved-organic-carbon-doc-at-three-remote-stations-in-the-himalayas-and-tibetan-plateau-china
#18
Chaoliu Li, Fangping Yan, Shichang Kang, Pengfei Chen, Zhaofu Hu, Xiaowen Han, Guoshuai Zhang, Shaopeng Gao, Bin Qu, Mika Sillanpää
The concentrations, depositions and optical properties of precipitation DOC at three remote stations (Nam Co, Lulang and Everest) were investigated in the Himalayas and Tibetan Plateau (HTP). The results showed that their volume-weighted mean DOC concentrations were 1.05±1.01mgCL(-1), 0.83±0.85mgCL(-1) and 0.86±0.91mgCL(-1), respectively, close to those of other remote areas in the world and lower than those of typical polluted urban cities. Combined with precipitation amounts, the DOC depositions at these three stations were calculated to be 0...
July 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28707563/studies-on-removal-of-phenol-sulfonic-acid-syntan-in-aqueous-medium-using-ozonation
#19
Rema Thankappan, S V Srinivasan, R Suthanthararajan, Mika Sillanpää
The removal of Phenol Sulfonic Acid-Syntan (PSAS) in terms of Chemical Oxygen Demand (COD) was studied at different pH, Ozone and initial PSAS concentrations and the optimum condition was found to be pH 7, ozone concentration of 5.2 ×10(-)(3)mmol/L and initial PSAS concentration of 500 mg/L. The increase in BOD5/COD ratio confirmed the bio-treatability of ozonated PSAS effluent. The Excitation Emission Matrix (EEM) intensity and Fourier Transmission Infra-red spectroscopy (FTIR) confirmed the generation of intermediate by-product during degradation of PSAS...
July 14, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28707279/sarcolipin-expression-is-repressed-by-endoplasmic-reticulum-stress-in-c2c12-myotubes
#20
Nobuhiko Takahashi, Atsushi P Kimura, Sumiyoshi Naito, Mika Yoshida, Osamu Kumano, Takeshi Suzuki, Satoshi Itaya, Mitsuru Moriya, Masahiro Tsuji, Masahiro Ieko
Sarcolipin is a transmembrane protein expressed in the sarco/endoplasmic reticulum of skeletal and atrial muscles in large animals. Sarcolipin plays crucial roles in heat production through modifying the function of sarco/endoplasmic reticulum Ca(2+) ATPase, thereby being involved in thermogenesis and systemic metabolism. In skeletal muscle, endoplasmic reticulum (ER) stress has been implicated in several conditions, such as insulin resistance, muscle diseases, and hypo/hyper-contraction. Here, we investigated the effect of ER stress on sarcolipin expression in skeletal muscle cells, C2C12 myotubes...
July 13, 2017: Journal of Physiology and Biochemistry
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