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https://www.readbyqxmd.com/read/29783137/body-composition-as-a-predictor-of-physical-performance-in-older-age-a-ten-year-follow-up-of-the-helsinki-birth-cohort-study
#1
Tuija M Mikkola, Mikaela B von Bonsdorff, Minna K Salonen, Mika Simonen, Pertti Pohjolainen, Clive Osmond, Mia-Maria Perälä, Taina Rantanen, Eero Kajantie, Johan G Eriksson
BACKGROUND: This study assessed how different measures of body composition predict physical performance ten years later among older adults. METHODS: The participants were 1076 men and women aged 57 to 70 years. Body mass index (BMI), waist circumference, and body composition (bioelectrical impedance analysis) were measured at baseline and physical performance (Senior Fitness Test) ten years later. Linear regression analyses were adjusted for age, education, smoking, duration of the follow-up and physical activity...
May 14, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29782904/intracellular-s1p-levels-dictates-fate-of-different-regions-of-the-hippocampus-following-transient-global-cerebral-ischemia
#2
Sherif Rashad, Kuniyasu Niizuma, Daisuke Saigusa, Xiaobo Han, Mika Sato-Maeda, Ritsumi Saito, Akira Uruno, Miki Fujimura, Shuntaro Ikawa, Masayuki Yamamoto, Teiji Tominaga
Sphingosine-1-phosphate (S1P) is a sphingolipid molecule produced by the action of sphingosine kinases (SphK) on sphingosine. It possesses various intracellular functions through its interactions with intracellular proteins or via its action on five G-protein-coupled cell membrane receptors. Following transient global cerebral ischaemia (tGCI), only the CA1 subregion of the hippocampus undergoes apoptosis. In this study, we evaluated S1P levels and S1P processing enzyme expression in different hippocampal areas following tGCI in rats...
May 18, 2018: Neuroscience
https://www.readbyqxmd.com/read/29782486/clinical-socioeconomic-and-behavioural-factors-at-age-50-years-and-risk-of-cardiometabolic-multimorbidity-and-mortality-a-cohort-study
#3
Archana Singh-Manoux, Aurore Fayosse, Séverine Sabia, Adam Tabak, Martin Shipley, Aline Dugravot, Mika Kivimäki
BACKGROUND: Multimorbidity is increasingly common and is associated with adverse health outcomes, highlighting the need to broaden the single-disease framework that dominates medical research. We examined the role of midlife clinical characteristics, socioeconomic position, and behavioural factors in the development of cardiometabolic multimorbidity (at least 2 of diabetes, coronary heart disease, and stroke), along with how these factors modify risk of mortality. METHODS AND FINDINGS: Data on 8,270 men and women were drawn from the Whitehall II cohort study, with mean follow-up of 23...
May 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29781088/delivery-and-its-complications-among-women-of-somali-kurdish-and-russian-origin-and-women-in-the-general-population-in-finland
#4
Kalpana Bastola, Päivikki Koponen, Tommi Härkänen, Riitta Luoto, Mika Gissler, Tarja I Kinnunen
INTRODUCTION: Limited information is available on delivery and its complications among migrant women in Finland. We compared mode of delivery, delivery complications, and use of pain medication during delivery between migrant women of Somali, Kurdish, and Russian origin and women in the general population in Finland. METHODS: The women were of Russian (n = 318), Somali (n = 583), and Kurdish (n = 373) origin and 243 women from the general population (reference group) who had given birth in Finland between 2004 and 2014...
May 20, 2018: Birth
https://www.readbyqxmd.com/read/29780434/engineered-sulfur-resistant-catalyst-system-with-an-assisted-regeneration-strategy-for-lean-burn-methane-combustion
#5
Niko M Kinnunen, Matthew Keenan, Kauko Kallinen, Teuvo Maunula, Mika Suvanto
Catalytic combustion of methane, the main component of natural gas, is a challenge under lean-burn conditions and at low temperatures owing to sulfur poisoning of the Pd-rich catalyst. This paper introduces a more sulfur-resistant catalyst system that can be regenerated during operation. The developed catalyst system lowers the barrier that has restrained the use of liquefied natural gas as a fuel in energy production.
April 9, 2018: ChemCatChem
https://www.readbyqxmd.com/read/29780114/successful-treatment-of-hemophagocytic-lymphohistiocytosis-associated-with-low-risk-myelodysplastic-syndrome-by-azacitidine
#6
Shinya Daitoku, Tomomi Aoyagi, Shinichiro Takao, Seiya Tada, Mika Kuroiwa
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome that occurs as a complication in many clinical settings. Malignancy-associated HLH develops in patients with hematopoietic neoplasms, particularly in those with lymphoma, and its development in those with myelodysplastic syndrome (MDS) is uncommon. We herein report a case of HLH in a patient with low-risk MDS that was successfully treated with azacitidine. The prevalence of immune abnormalities among MDS patients and the immune effects of azacitidine have recently been elucidated, suggesting that MDS-associated HLH occurs as a result of immune impairment, and azacitidine improves this condition by restoring the immune system...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29780044/-effect-of-misregistration-between-spect-and-ct-images-on-attenuation-correction-for-quantitative-bone-spect-imaging
#7
Mika Sakoshi, Norikazu Matsutomo, Tomoaki Yamamoto, Eisuke Sato
PURPOSE: The aim of this study was to evaluate the effect of misregistration between single-photon emission computed tomography (SPECT) and computed tomography (CT) images on bone SPECT. METHODS: We acquired SPECT and CT images of a body phantom filled with bone-equivalent solution and 99m Tc for evaluation of bone SPECT. SPECT images were reconstructed using attenuation correction maps obtained by shifting the attenuation coefficients from non-shifted values (reference)...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29779930/a-sialylated-voltage-dependent-ca-2-channel-binds-hemagglutinin-and-mediates-influenza-a-virus-entry-into-mammalian-cells
#8
Yoichiro Fujioka, Shinya Nishide, Toyoyuki Ose, Tadaki Suzuki, Izumi Kato, Hideo Fukuhara, Mari Fujioka, Kosui Horiuchi, Aya O Satoh, Prabha Nepal, Sayaka Kashiwagi, Jing Wang, Mika Horiguchi, Yuko Sato, Sarad Paudel, Asuka Nanbo, Tadaaki Miyazaki, Hideki Hasegawa, Katsumi Maenaka, Yusuke Ohba
Influenza A virus (IAV) infection is initiated by the attachment of the viral glycoprotein hemagglutinin (HA) to sialic acid on the host cell surface. However, the sialic acid-containing receptor crucial for IAV infection has remained unidentified. Here, we show that HA binds to the voltage-dependent Ca2+ channel Cav 1.2 to trigger intracellular Ca2+ oscillations and subsequent IAV entry and replication. IAV entry was inhibited by Ca2+ channel blockers (CCBs) or by knockdown of Cav 1.2. The CCB diltiazem also inhibited virus replication in vivo...
May 10, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29777612/clustering-of-job-strain-effort-reward-imbalance-and-organizational-injustice-and-the-risk-of-work-disability-a-cohort-study
#9
Anne Juvani, Tuula la Oksanen, Marianna Virtanen, Paula Salo, Jaana Pentti, Mika Kivimäki, Jussi Vahtera
Objectives The aim of this study was to examine the association between co-occurring work stressors and risk of disability pension. Methods The work stressors job strain, effort-reward imbalance (ERI), and organizational injustice were measured by a survey in 2008 of 41 862 employees linked to national records of all-cause and cause-specific disability pensions until 2011. Co-occurring work stressors were examined as risk factors of work disability using Cox regression marginal models. Results Work stressors were clustered: 50...
May 2, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29777511/a-case-of-pancake-kidney-with-a-single-ureter-in-the-retroperitoneal-space
#10
Kasuga Horai, Munekazu Naito, Tomiko Yakura, Yuka Furuya, Yusuke Ohmichi, Mika Ohmichi, Takayoshi Miyaki, Takashi Nakano
The pancake kidney (PK) is a rare type of renal anomaly in which both kidneys completely fuse without an isthmus. In the previous reports, PKs have double ureters and are located in the pelvic cavity. We encountered a rare case of PK with a single ureter, which is located in the left retroperitoneal space, in a 95-year-old female cadaver, which was detected during a dissection course. In our case, the major calyces joined to form a single renal pelvis, which continued as a single ureter. To the best of our knowledge, this is the first report on PK with a single ureter that is located not in the pelvic cavity but in the retroperitoneal space...
May 18, 2018: Anatomical Science International
https://www.readbyqxmd.com/read/29777310/mechanical-sensitivity-and-psychological-factors-in-patients-with-burning-mouth-syndrome
#11
Mika Honda, Takashi Iida, Hirona Kamiyama, Manabu Masuda, Misao Kawara, Peter Svensson, Osamu Komiyama
OBJECTIVES: The aim of this study was to compare mechanical sensitivity on the tongue using quantitative sensory testing (QST) and psychological factors using the General Health Questionnaire (GHQ) between burning mouth syndrome (BMS) patients and healthy participants. MATERIALS AND METHODS: Participants comprised 20 female BMS patients (68.1 ± 7.4 years) and 20 healthy females (65.4 ± 4.6 years). Psychological factors were evaluated with GHQ. Tactile detection thresholds (TDT) and filament-prick pain detection thresholds (FPT) were used to evaluate mechanical sensitivity on the tongue in all participants...
May 18, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29775476/maternal-asthma-is-associated-with-increased-risk-of-perinatal-mortality
#12
Mari Kemppainen, Anna-Maria Lahesmaa-Korpinen, Paula Kauppi, Martti Virtanen, Suvi M Virtanen, Riitta Karikoski, Mika Gissler, Turkka Kirjavainen
BACKGROUND: Asthma is the most common chronic disease during pregnancy and it may have influence on pregnancy outcome. OBJECTIVES: Our goal was to assess the association between maternal asthma and the perinatal risks as well as possible effects of asthma medication. METHODS: The study was based on a nationwide Finnish register-based cohort between the years 1996 and 2012 in the Drug and Pregnancy Database. The register data comprised 962 405 singleton live and stillbirths, 898 333 (93...
2018: PloS One
https://www.readbyqxmd.com/read/29775134/csf-inflammatory-biomarkers-responsive-to-treatment-in-progressive-multiple-sclerosis-capture-residual-inflammation-associated-with-axonal-damage
#13
Jeppe Romme Christensen, Mika Komori, Marina Rode von Essen, Rikke Ratzer, Lars Börnsen, Bibi Bielekova, Finn Sellebjerg
BACKGROUND: Development of treatments for progressive multiple sclerosis (MS) is challenged by the lack of sensitive and treatment-responsive biomarkers of intrathecal inflammation. OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers. METHODS: CSF samples from two open-label phase II trials of natalizumab and methylprednisolone in primary and secondary progressive MS...
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29771117/correlating-charge-transport-to-structure-in-deconstructed-diketopyrrolopyrrole-oligomers-a-case-study-of-a-monomer-in-field-effect-transistors
#14
Alec Pickett, Mika Torkkeli, Tushita Mukhopadhyay, Boregowda Puttaraju, Amrit Laudari, Andreas Lauritzen, Oier Bikondoa, Jakob Kjelstrup-Hansen, Matti Knaapila, Satish Patil, Suchismita Guha
Copolymers based on diketopyrrolopyrrole (DPP) cores have attracted a lot of attention due to their high p-type as well as n-type carrier mobilities in organic field-effect transistors (FETs) and high power conversion efficiencies in solar cell structures. We report the structural and charge transport properties of n-dialkyl side-chain substituted thiophene DPP end-capped with a phenyl group (Ph-TDPP-Ph) in FETs which were fabricated by vacuum deposition and solvent coating. Grazing incidence X-ray diffraction (GIXRD) from bottom-gate, bottom-contact FET architectures were measured with and without biasing...
May 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29770405/a-synthetic-no-reduction-cycle-on-a-bis-pyrazolato-bridged-dinuclear-ruthenium-complex-including-photo-induced-transformation
#15
Yasuhiro Arikawa, Junko Hiura, Chika Tsuchii, Mika Kodama, Naoki Matsumoto, Keisuke Umakoshi
A synthetic NO reduction cycle (2NO + 2H+ + 2e- → N2O + H2O) on a dinuclear platform {(TpRu)2(μ-pz)2} (Tp = HB(pyrazol-1-yl)3) was achieved, where an unusual N-N coupling complex was included. Moreover, an interesting photo-induced conversion of the N-N coupling complex to an oxido-bridged complex was revealed.
May 17, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29769433/medical-imaging-dose-optimization-from-ground-up-expert-opinion-of-an-international-summit
#16
Ehsan Samei, Hannu Jarvinen, Mika Kortesniemi, Georgios Simantirakis, Charles Goh, Anthony Wallace, Eliseo Vano, Adrian Bejan, M M Rehani, J Vassileva
As in any medical intervention, there is either a known or an anticipated benefit to the patient from undergoing a medical imaging procedure. This benefit is generally significant as demonstrated by the manner in which medical imaging has transformed clinical medicine. At the same time, when it comes to imaging that deploys ionizing radiation, there is a potential associated risk from radiation. Radiation risk has been recognized as a key liability in the practice of medical imaging, creating a motivation for radiation dose optimization...
May 17, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29769258/anti-tumor-efficacy-of-a-novel-clk-inhibitor-via-targeting-rna-splicing-and-myc-dependent-vulnerability
#17
Kenichi Iwai, Masahiro Yaguchi, Kazuho Nishimura, Yukiko Yamamoto, Toshiya Tamura, Daisuke Nakata, Ryo Dairiki, Yoichi Kawakita, Ryo Mizojiri, Yoshiteru Ito, Moriteru Asano, Hironobu Maezaki, Yusuke Nakayama, Misato Kaishima, Kozo Hayashi, Mika Teratani, Shuichi Miyakawa, Misa Iwatani, Maki Miyamoto, Michael G Klein, Wes Lane, Gyorgy Snell, Richard Tjhen, Xingyue He, Sai Pulukuri, Toshiyuki Nomura
The modulation of pre-mRNA splicing is proposed as an attractive anti-neoplastic strategy, especially for the cancers that exhibit aberrant pre-mRNA splicing. Here, we discovered that T-025 functions as an orally available and potent inhibitor of Cdc2-like kinases (CLKs), evolutionally conserved kinases that facilitate exon recognition in the splicing machinery. Treatment with T-025 reduced CLK-dependent phosphorylation, resulting in the induction of skipped exons, cell death, and growth suppression in vitro and in vivo Further, through growth inhibitory characterization, we identified high CLK2 expression or MYC amplification as a sensitive-associated biomarker of T-025...
May 16, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29767524/resonant-gisaxs-at-the-sulfur-k-edge-for-material-specific-investigation-of-thin-film-nanostructures
#18
Mihael Coric, Nitin Saxena, Mika Pflüger, Peter Muller-Buschbaum, Michael Krumrey, Eva M Herzig
Scattering techniques are a powerful tool for probing thin film nanomorphologies, but often require additional characterization by other methods. We applied the well-established grazing-incidence small angle X-ray scattering (GISAXS) technique for a selection of energies around the absorption edge of sulfur to exploit the resonance effect (grazing incidence resonant tender X-ray scattering - GIR-TeXS) of the sulfur atoms within a P3HT-PCBM sample to gain information about the composition of the film morphology...
May 16, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29767461/sex-differences-but-no-evidence-of-quantitative-honesty-in-the-warning-signals-of-six-spot-burnet-moths-zygaena-filipendulae-l
#19
Emmanuelle Sophie Briolat, Mika Zagrobelny, Carl Erik Olsen, Jonathan D Blount, Martin Stevens
The distinctive black and red wing pattern of six-spot burnet moths (Zygaena filipendulae, L.) is a classic example of aposematism, advertising their potent cyanide-based defences. While such warning signals provide a qualitatively honest signal of unprofitability, the evidence for quantitative honesty, whereby variation in visual traits could provide accurate estimates of individual toxicity, is more equivocal. Combining measures of cyanogenic glucoside content and wing colour from the perspective of avian predators, we investigate the relationship between coloration and defences in Z...
May 16, 2018: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29765527/lpmab-23-recognizing-cancer-type-podoplanin-is-a-novel-predictor-for-a-poor-prognosis-of-early-stage-tongue-cancer
#20
Akihiro Miyazaki, Hiromi Nakai, Tomoko Sonoda, Yoshihiko Hirohashi, Mika K Kaneko, Yukinari Kato, Yoshihiko Sawa, Hiroyoshi Hiratsuka
Purpose: We report that the reactivity of a novel monoclonal antibody LpMab-23 for human cancer-type podoplanin (PDPN) is a predictor for a poor prognosis of tongue cancer. Patients and Methods: The association between LpMab-23-recognizing cancer-type PDPN expression and clinical/pathological features were analyzed on 60 patients with stage I and II tongue cancer treated with transoral resection of the primary tumor. Results: In the mode of invasion, the LpMab-23-dull/negative cases were significantly larger in cases with low-grade malignancies and without late cervical lymph node metastasis, than in cases with high-grade malignancies and the metastasis...
April 20, 2018: Oncotarget
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