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https://www.readbyqxmd.com/read/28440492/axl-and-gas6-co-expression-in-lung-adenocarcinoma-as-a-prognostic-classifier
#1
Masahiro Seike, Cheol-Hong Kim, Fenfei Zou, Rintaro Noro, Mika Chiba, Arimi Ishikawa, Shinobu Κunugi, Kaoru Kubota, Akihiko Gemma
AXL, a receptor tyrosine kinase implicated in cell survival, proliferation, and migration, is also associated with acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor therapy. However, its prognostic significance in lung adenocarcinoma (AD) remains unclear. We therefore evaluated the prognostic significance of the expression of AXL and/or its ligand, growth arrest-specific 6 (GAS6), in completely resected lung AD. We evaluated the relationship between AXL, GAS6, and vimentin expression, as determined by immunohistochemistry (IHC) analysis, with overall survival and disease-free survival in 113 patients with stages I-III lung AD...
April 21, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28439075/switch-from-ambient-to-focal-processing-mode-explains-the-dynamics-of-free-viewing-eye-movements
#2
Junji Ito, Yukako Yamane, Mika Suzuki, Pedro Maldonado, Ichiro Fujita, Hiroshi Tamura, Sonja Grün
Previous studies have reported that humans employ ambient and focal modes of visual exploration while they freely view natural scenes. These two modes have been characterized based on eye movement parameters such as saccade amplitude and fixation duration, but not by any visual features of the viewed scenes. Here we propose a new characterization of eye movements during free viewing based on how eyes are moved from and to objects in a visual scene. We applied this characterization to data obtained from freely-viewing macaque monkeys...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28433169/effectiveness-of-n-o-carboxymethyl-chitosan-on-destabilization-of-marine-diesel-diesel-and-marine-2t-oil-for-oil-spill-treatment
#3
Bhairavi Doshi, Eveliina Repo, Juha P Heiskanen, Juho Antti Sirviö, Mika Sillanpää
Oil spills are the significant sources of hydrocarbons entering in the receiving aquatic environment. An efficient method to remove hydrocarbons from water resources is adsorption. In this study, water soluble N,O-carboxymethyl chitosan (NO-CS) was synthesized by carboxymethylation of chitosan in a hydro-alcoholic medium at 50°C by chloroacetic acid. The polymer was characterized through degree of deacetylation, degree of substitution, FTIR and (1)H NMR. Effectiveness of NO-CS as an adsorbent was studied as a function of dosage, salinity and pH to destabilize the Marine diesel (Oil-1), Diesel (Oil-2) and Marine-2T oil (Oil-3) into small oil droplets of less than 100μm...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28432332/involvement-of-gonadotropin-inhibitory-hormone-in-pubertal-disorders-induced-by-thyroid-status
#4
Mika Kiyohara, You Lee Son, Kazuyoshi Tsutsui
Thyroid disorders cause abnormal puberty, indicating interactions between the hypothalamus-pituitary-thyroid (HPT) and hypothalamus-pituitary-gonadal (HPG) axes, which are important in pubertal development. The hypothalamic gonadotropin-inhibitory hormone (GnIH) was shown to be decreased in the early prepubertal stage, suggesting the role of GnIH on pubertal onset. Here, we investigated whether thyroid dysfunction affects pubertal onset in female mice via GnIH regulation. Hypothyroidism showed delayed pubertal onset with increased GnIH expression and reduced pituitary-gonadal activity...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28431477/duration-of-orthognathic-surgical-treatment
#5
Jaakko Paunonen, Mika Helminen, Timo Peltomäki
OBJECTIVE: The objective of this study was to determine the duration of orthognathic-surgical treatment conducted with conventional pre- and post-surgical orthodontic treatment phases. MATERIAL AND METHODS: The study material was comprised of the files of 185 consecutive patients treated in Oral and Maxillofacial Unit, Tampere University Hospital, Finland, in 2007-2014. The files were reviewed and the following data was obtained: gender and age of patients, ICD-10 diagnosis, type of malocclusion, duration of pre- and post-surgical orthodontic treatment and type of operation...
April 21, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28431015/large-scale-collection-of-full-length-cdna-and-transcriptome-analysis-in-hevea-brasiliensis
#6
Yuko Makita, Kiaw Kiaw Ng, G Veera Singham, Mika Kawashima, Hideki Hirakawa, Shusei Sato, Ahmad Sofiman Othman, Minami Matsui
Natural rubber has unique physical properties that cannot be replaced by products from other latex-producing plants or petrochemically produced synthetic rubbers. Rubber from Hevea brasiliensis is the main commercial source for this natural rubber that has a cis-polyisoprene configuration. For sustainable production of enough rubber to meet demand elucidation of the molecular mechanisms involved in the production of latex is vital. To this end, we firstly constructed rubber full-length cDNA libraries of RRIM 600 cultivar and sequenced around 20,000 clones by the Sanger method and over 15,000 contigs by Illumina sequencer...
April 1, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28429146/clinical-validity-of-biochemical-and-molecular-analysis-in-diagnosing-leigh-syndrome-a-study-of-106-japanese-patients
#7
Erika Ogawa, Masaru Shimura, Takuya Fushimi, Makiko Tajika, Keiko Ichimoto, Ayako Matsunaga, Tomoko Tsuruoka, Mika Ishige, Tatsuo Fuchigami, Taro Yamazaki, Masato Mori, Masakazu Kohda, Yoshihito Kishita, Yasushi Okazaki, Shori Takahashi, Akira Ohtake, Kei Murayama
Leigh syndrome (LS) is a progressive neurodegenerative disorder of infancy and early childhood. It is clinically diagnosed by typical manifestations and characteristic computed tomography (CT) or magnetic resonance imaging (MRI) studies. Unravelling mitochondrial respiratory chain (MRC) dysfunction behind LS is essential for deeper understanding of the disease, which may lead to the development of new therapies and cure. The aim of this study was to evaluate the clinical validity of various diagnostic tools in confirming MRC disorder in LS and Leigh-like syndrome (LL)...
April 20, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28427078/a-case-of-adult-metastatic-rhabdomyosarcoma-of-the-prostate-cured-by-long-term-chemotherapy-with-local-radiation
#8
Masato Konno, Koji Mitsuzuka, Shigeyuki Yamada, Shinichi Yamashita, Yasuhiro Kaiho, Akihiro Ito, Mika Watanabe, Yoichi Arai
A 32-year-old man visited our hospital due to urinary retention. Prostate-specific antigen was 13.7 ng/mL. Imaging examinations showed a large prostatic tumor and lung and internal iliac lymph node metastases. Transrectal biopsy confirmed embryonal rhabdomyosarcoma of the prostate classified as cT2bN1M1 (stage IV) by the International Rhabdomyosarcoma Study (IRS) Group staging system. Systemic chemotherapy was started according to the IRS III regimen 36, which consisted of 16 weeks of induction chemotherapy with radiation...
April 21, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28426937/high-throughput-quantitative-intrinsic-thiol-reactivity-evaluation-using-a-fluorescence-based-competitive-endpoint-assay
#9
Tomoya Sameshima, Ikuo Miyahisa, Seiji Yamasaki, Mika Gotou, Toshitake Kobayashi, Junichi Sakamoto
In a high-throughput screening (HTS) process, the chemical reactivity of test samples should be carefully examined because such reactive compounds may lead to false-positive results and adverse effects in vivo. Among all natural amino acids, the thiol side chain in cysteine has the highest nucleophilicity; thus, assessment of intrinsic thiol group reactivity in the HTS processes is expected to accelerate drug discovery. In general, kchem (M(-1)s(-1)), the secondary reaction rate constant of a compound to thiol, can be evaluated via time course measurements of thiol-compound adducts using liquid chromatography-mass spectroscopy; this requires time-consuming and labor-intensive procedures...
April 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28426602/in-reply
#10
Jaana Männistö, Aini Bloigu, Maarit Mentula, Mika Gissler, Oskari Heikinheimo, Maarit Niinimäki
No abstract text is available yet for this article.
May 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28425589/national-rates-of-uterine-rupture-are-not-associated-with-rates-of-previous-caesarean-delivery-results-from-the-nordic-obstetric-surveillance-study
#11
Lotte B Colmorn, Jens Langhoff-Roos, Maija Jakobsson, Anna-Maija Tapper, Mika Gissler, Pelle G Lindqvist, Karin Källen, Karin Gottvall, Kari Klungsøyr, Per Bøhrdahl, Ragnhild I Bjarnadóttir, Lone Krebs
BACKGROUND: Previous caesarean delivery and intended mode of delivery after caesarean are well-known individual risk factors for uterine rupture. We examined if different national rates of uterine rupture are associated with differences in national rates of previous caesarean delivery and intended mode of delivery after a previous caesarean delivery. METHODS: This study is an ecological study based on data from a retrospective cohort in the Nordic countries. Data on uterine rupture were collected prospectively in each country as part of the Nordic obstetric surveillance study and included 91% of all Nordic deliveries...
April 20, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28422173/critical-involvement-of-zeb2-in-collagen-fibrillogenesis-the-molecular-similarity-between-mowat-wilson-syndrome-and-ehlers-danlos-syndrome
#12
Mika Teraishi, Mikiro Takaishi, Kimiko Nakajima, Mitsunori Ikeda, Yujiro Higashi, Shinji Shimoda, Yoshinobu Asada, Atsushi Hijikata, Osamu Ohara, Yoko Hiraki, Seiji Mizuno, Toshiyuki Fukada, Takahisa Furukawa, Nobuaki Wakamatsu, Shigetoshi Sano
Mowat-Wilson syndrome (MOWS) is a congenital disease caused by de novo heterozygous loss of function mutations or deletions of the ZEB2 gene. MOWS patients show multiple anomalies including intellectual disability, a distinctive facial appearance, microcephaly, congenital heart defects and Hirschsprung disease. However, the skin manifestation(s) of patients with MOWS has not been documented in detail. Here, we recognized that MOWS patients exhibit many Ehlers-Danlos syndrome (EDS)-like symptoms, such as skin hyperextensibility, atrophic scars and joint hypermobility...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421239/weight-bearing-recommendations-after-operative-fracture-treatment-fact-or-fiction-gait-results-with-and-feasibility-of-a-dynamic-continuous-pedobarography-insole
#13
Benedikt J Braun, Nils T Veith, Mika Rollmann, Marcel Orth, Tobias Fritz, Steven C Herath, Jörg H Holstein, Tim Pohlemann
PURPOSE: Rehabilitation after lower-extremity fractures is based on the physicians' recommendation for non-, partial-, or full weight-bearing. Clinical studies rely on this assumption, but continuous compliance or objective loading rates are unknown. The purpose of this study was to determine the compliance to weight-bearing recommendations by introducing a novel, pedobarography system continuously registering postoperative ground forces into ankle, tibial shaft and proximal femur fracture aftercare and test its feasibility for this purpose...
April 19, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28420846/intrathecal-isoniazid-for-refractory-tuberculous-meningitis-with-cerebral-infarction
#14
Yuko Nakatani, Yutaka Suto, Kazuki Fukuma, Mika Yamawaki, Ryoichi Sakata, Shotaro Takahashi, Hiroyuki Nakayasu, Kenji Nakashima
A 30-year-old Vietnamese woman, about 19 weeks pregnant, was admitted for acute cerebral infarction with stenosis of the left middle cerebral artery (LMCA), tuberculous meningitis, and miliary tuberculosis. Treatment with heparin, quadruple anti-tuberculosis therapy, and dexamethasone afforded prompt symptomatic improvement. However, she delivered a stillbirth, after which there was recurrence of acute cerebral infarction with LMCA occlusion, sinus thrombosis, and cranial base inflammation. A thrice-weekly 100 mg dose of intrathecal isoniazid (INH) improved the signs of meningeal inflammation...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28420837/clinical-characteristics-of-rheumatoid-arthritis-patients-achieving-functional-remission-with-six-months-of-biological-dmards-treatment
#15
Yusuke Miwa, Ryo Takahashi, Yuzo Ikari, Airi Maeoka, Shinichiro Nishimi, Nao Oguro, Tomoki Hayashi, Mika Hatano, Sakiko Isojima, Ryo Yanai, Tsuyoshi Kasama, Yoichi Toyoshima, Katsunori Inagaki, Kenji Sanada
Objective Although previous studies have reported the prognostic factors for functional remission, no reports have cited the predictive factors. Our aim was to study the predictive factors for functional remission, which is a treatment goal in rheumatoid arthritis (RA), after receiving biological disease-modifying antirheumatic drugs (bDMARDs) treatment for six months. Methods The study consisted of 333 RA patients treated with bDMARDs for six months. The following patient characteristics were investigated: age, gender, disease duration, type of bDMARDs, baseline steroid and methotrexate dosage, and levels of serum rheumatoid factor, matrix metalloprotease, anti-cyclic citrullinated peptides antibody, tumor necrosis factor-α, and interleukin-6...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28415474/palladium-nanoparticles-in-electrochemical-sensing-of-trace-terazosin-in-human-serum-and-pharmaceutical-preparations
#16
Yasaman Sefid-Sefidehkhan, Khadijeh Nekoueian, Mandana Amiri, Mika Sillanpaa, Habibollah Eskandari
In this approach, palladium nanoparticle film was simply fabricated on the surface of carbon paste electrode by electrochemical deposition method. The film was characterized using scanning electron microscopy, electrochemical impedance spectroscopy and cyclic voltammetry. The prepared electrode exhibited an excellent electrocatalytic activity toward detection of trace amounts of terazosin, which is an antihypertensive drug. Under the optimum experimental conditions, a linear range of 1.0×10(-8)-1.0×10(-3)molL(-1) with a detection limit of 1...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414955/influence-of-relaxation-modes-on-membrane-fouling-in-submerged-membrane-bioreactor-for-domestic-wastewater-treatment
#17
Rasikh Habib, Muhammad Bilal Asif, Sidra Iftekhar, Zahiruddin Khan, Khum Gurung, Varsha Srivastava, Mika Sillanpää
Relaxation and backwashing have become an integral part of membrane bioreactor (MBR) operations for fouling control. This study was carried out on real municipal wastewater to evaluate the influence of different operational strategies on membrane fouling at equivalent water yield. Four relaxation modes (MBR10+0, MBR10+1, MBR10+1.5 and MBR10+2) were tested to analyze membrane fouling behavior. For the optimization of relaxation modes, fouling rate in terms of trans-membrane pressure, hydraulic resistances and characteristics of fouling fractions were analyzed...
April 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28414469/correlations-between-structure-and-near-infrared-spectra-of-saturated-and-unsaturated-carboxylic-acids-an-insight-from-anharmonic-dft-calculations
#18
Justyna Grabska, Mika Ishigaki, Krzysztof Bernard Beć, Marek Janusz Wojcik, Yukihiro Ozaki
By near-infrared (NIR) spectroscopy and anharmonic DFT calculations we investigate five kinds of saturated and unsaturated carboxylic acids belonging to the group of short-chain fatty acids; propionic acid, butyric acid, acrylic acid, crotonic acid and vinylacetic acid. The experimental NIR spectra of these five kinds of carboxylic acids are reproduced by quantum chemical calculations in a broad spectral region of 7500-4000 cm(-1) and for a wide range of concentrations. By employing anharmonic GVPT2 calculations on DFT level, a detailed interpretation of experimental spectra is achieved, elucidating structure-spectra correlations of these molecules in the NIR region...
April 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28412853/nitrogen-behaviour-during-thermal-drying-of-mechanically-dewatered-biosludge-from-pulp-and-paper-industry
#19
Kati Mustonen, Ivan Deviatkin, Jouni Havukainen, Mika Horttanainen
An ongoing call to implement a circular economy is underway in the European Union, and a specific attention has been placed on the forest industry, which seeks additional recycling routes for its side streams, including biosludge. Biosludge is often dried and incinerated, thus wasting the nitrogen contained therein. This paper describes a study in which the release of nitrogen during thermal drying; the impact of the drying temperatures of 130, 180, and 210°C on the mass of ammonia released; and the potential for recovery of nitrogen from biosludge were examined...
April 17, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28412613/intensified-emotion-perception-in-depression-differences-in-physiological-arousal-and-subjective-perceptions
#20
Sofia Wenzler, Marleen Hagen, Mika P Tarvainen, Marietheres Hilke, Naddy Ghirmai, Ann-Caitlin Huthmacher, Marco Trettin, Rolf van Dick, Andreas Reif, Viola Oertel-Knöchel
People suffering from depression perceive themselves and their surroundings as more negative than healthy ones. An explanation might be that depressed individuals experience negative information as more stressful than non-depressed subjects and, consequently, respond in an amplified manner on a subjective and physiological level. To test this proposition, we presented 41 patients with recurrent depressive episodes and 42 controls with stimuli from the International Affective Picture System split into three valence categories while different parameters of physiological arousal (e...
April 2, 2017: Psychiatry Research
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