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https://www.readbyqxmd.com/read/28529379/separating-or-sum-and-xor-circuits
#1
Magnus Find, Mika Göös, Matti Järvisalo, Petteri Kaski, Mikko Koivisto, Janne H Korhonen
Given a boolean n × n matrix A we consider arithmetic circuits for computing the transformation x ↦ Ax over different semirings. Namely, we study three circuit models: monotone OR-circuits, monotone SUM-circuits (addition of non-negative integers), and non-monotone XOR-circuits (addition modulo 2). Our focus is on separating OR-circuits from the two other models in terms of circuit complexity: We show how to obtain matrices that admit OR-circuits of size O(n), but require SUM-circuits of size Ω(n(3/2)/log(2)n)...
August 2016: Journal of Computer and System Sciences
https://www.readbyqxmd.com/read/28526193/effects-of-multiple-breath-hold-reproducibility-on-treatment-localization-and-dosimetric-accuracy-in-radiotherapy-of-left-sided-breast-cancer-with-voluntary-deep-inspiration-breath-hold-technique
#2
Mika Kapanen, Marko Laaksomaa, Jani Pehkonen, Mikko Haltamo, Helmi Luukkanen, Turkka Lehtonen, Simo Hyödynmaa, Pirkko-Liisa Kellokumpu-Lehtinen
The purpose of this study was to investigate the effects of breath hold reproducibility on positional and dosimetric errors in radiotherapy of patients with left-sided breast cancer (LSBC) treated with voluntary deep inspiration breath hold (vDIBH) technique. Clinical data from 2 groups of patients with LSBC were retrospectively investigated: (1) those irradiated for the whole breast only (WB group, n = 20) using typically from 3 to 5 breath holds per treatment session and (2) those irradiated simultaneously also for supraclavicular lymph nodes (WB + SLN group, n = 27) using from 7 to 9 breath holds per fraction...
May 16, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28525262/serum-protein-adsorption-enhances-active-leukemia-stem-cell-targeting-of-mesoporous-silica-nanoparticles
#3
Michaela Beck, Tamoghna Mandal, Christian Buske, Mika Lindén
The functionalization of nanoparticles with a ligand targeting receptors overexpressed by the target cells is a commonly used strategy when aiming at nanoparticle-based, cell type-specific drug delivery. However, the influence of particle surface chemistry on the targetability has received much less attention. The surface charge is known to directly or indirectly affect the nanoparticle cellular uptake kinetics by influencing serum protein adsorption. Thus, it is fair to assume that both the specificity and cellular uptake kinetics of targeted nanoparticles are influenced by the nanoparticle charge, both of which are important parameters for controlling cell-specific drug delivery efficiency...
May 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28524242/women-with-vulvodynia-awareness-and-knowledge-of-its-care-among-student-healthcare-staff
#4
Minna Törnävä, Meeri Koivula, Mika Helminen, Tarja Suominen
BACKGROUND: Many women with vulvodynia are women of fertile age, and this syndrome may cause many physical and psychosexual functional disorders. Women with vulvodynia often find that healthcare professionals seem to demonstrate a lack of awareness about the syndrome and its care. These issues have not been previously studied among student healthcare staff. AIM: To investigate awareness and knowledge about vulvodynia and its care among staff in the student healthcare sector in Finland...
May 19, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28522452/arthroscopic-partial-meniscectomy-versus-placebo-surgery-for-a-degenerative-meniscus-tear-a-2-year-follow-up-of-the-randomised-controlled-trial
#5
Raine Sihvonen, Mika Paavola, Antti Malmivaara, Ari Itälä, Antti Joukainen, Heikki Nurmi, Juha Kalske, Anna Ikonen, Timo Järvelä, Tero Ah Järvinen, Kari Kanto, Janne Karhunen, Jani Knifsund, Heikki Kröger, Tommi Kääriäinen, Janne Lehtinen, Jukka Nyrhinen, Juha Paloneva, Outi Päiväniemi, Marko Raivio, Janne Sahlman, Roope Sarvilinna, Sikri Tukiainen, Ville-Valtteri Välimäki, Ville Äärimaa, Pirjo Toivonen, Teppo Ln Järvinen
OBJECTIVE: To assess if arthroscopic partial meniscectomy (APM) is superior to placebo surgery in the treatment of patients with degenerative tear of the medial meniscus. METHODS: In this multicentre, randomised, participant-blinded and outcome assessor-blinded, placebo-surgery controlled trial, 146 adults, aged 35-65 years, with knee symptoms consistent with degenerative medial meniscus tear and no knee osteoarthritis were randomised to APM or placebo surgery. The primary outcome was the between-group difference in the change from baseline in the Western Ontario Meniscal Evaluation Tool (WOMET) and Lysholm knee scores and knee pain after exercise at 24 months after surgery...
May 18, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28521957/manufacturing-of-novel-low-cost-adsorbent-co-granulation-of-limestone-and-coffee-waste
#6
Evgenia Iakovleva, Mika Sillanpää, Philipp Maydannik, Jiang Tao Liu, Stephen Allen, Ahmad B Albadarin, Chirangano Mangwandi
Limestone and coffee waste were used during the wet co-granulation process for the production of efficient adsorbents to be used in the removal of anionic and cationic dyes. The adsorbents were characterized using different analytical techniques such as XRD, SEM, FTIR, organic elemental analysis, the nitrogen adsorption method, with wettability, strength and adsorption tests. The adsorption capacity of granules was determined by removal of methylene blue (MB) and orange II (OR) from single and mixed solutions...
May 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28514478/trajectories-of-depressive-symptoms-before-diagnosis-of-dementia-a-28-year-follow-up-study
#7
Archana Singh-Manoux, Aline Dugravot, Agnes Fournier, Jessica Abell, Klaus Ebmeier, Mika Kivimäki, Séverine Sabia
Importance: Neuropsychiatric symptoms, depressive symptoms in particular, are common in patients with dementia but whether depressive symptoms in adulthood increases the risk for dementia remains the subject of debate. Objective: To characterize the trajectory of depressive symptoms over 28 years prior to dementia diagnosis to determine whether depressive symptoms carry risk for dementia. Design, Setting, and Participants: Up to 10 308 persons, aged 35 to 55 years, were recruited to the Whitehall II cohort study in 1985, with the end of follow-up in 2015...
May 17, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28512139/a-genome-wide-association-meta-analysis-on-lipoprotein-a-concentrations-adjusted-for-apolipoprotein-a-isoforms
#8
Salome Mack, Stefan Coassin, Rico Rueedi, Noha A Yousri, Ilkka Seppälä, Christian Gieger, Sebastian Schönherr, Lukas Forer, Gertraud Erhart, Pedro Marques-Vidal, Janina Ried, Gerard Waeber, Sven Bergmann, Doreen Dähnhardt, Andrea Stöckl, Olli T Raitakari, Mika Kähönen, Annette Peters, Thomas Meitinger, Konstantin Strauch, Ludmilla Kedenko, Bernhard Paulweber, Terho Lehtimäki, Steven C Hunt, Peter Vollenweider, Claudia Lamina, Florian Kronenberg
High lipoprotein(a) [Lp(a)] concentrations are an independent risk factor for cardiovascular outcomes. Concentrations are strongly influenced by apo(a) KIV repeat isoforms. We aimed to identify genetic loci associated with Lp(a) concentrations using data from five genome-wide association studies (n=13,781). We identified 48 independent SNPs in the LPA and 1 SNP in the APOE gene region to be significantly associated with Lp(a) concentrations. We also adjusted for apo(a) isoforms to identify loci affecting Lp(a) levels independently from them, which resulted in 31 SNPs (30 in the LPA, 1 in the APOE gene region)...
May 16, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28511697/immunohistology-and-remodeling-in-fatal-pediatric-and-adolescent-asthma
#9
Kristiina Malmström, Jouko Lohi, Antti Sajantila, Frode L Jahnsen, Merja Kajosaari, Seppo Sarna, Mika J Mäkelä
BACKGROUND: Thickening of reticular basement membrane, increased airway smooth muscle mass and eosinophilic inflammation are found in adult fatal asthma. At the present study the histopathology of fatal paediatric and adolescent asthma is evaluated. METHODS: Post-mortem lung autopsies from 12 fatal asthma cases and 8 non-asthmatic control subjects were examined. Thickness of reticular basement membrane (RBM) and percentage of airway smooth muscle (ASM%) mass area were measured and inflammatory cells were counted...
May 16, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28510640/increased-risk-of-premature-death-following-teenage-abortion-and-childbirth-a-longitudinal-cohort-study
#10
Eerika Jalanko, Suvi Leppälahti, Oskari Heikinheimo, Mika Gissler
Teenage pregnancy is associated with an increased risk of premature death. However, it is not known whether the outcome of pregnancy, i.e. induced abortion or childbirth, affects this risk. A Finnish population-based register study involving a cohort of 13 691 nulliparous teenagers who conceived in 1987-89; 6652 of them underwent induced abortion and 7039 delivered. The control group consisted of 41 012 coeval women without teenage pregnancy. Follow-up started at the end of pregnancy and lasted until 6th June 2013...
May 16, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28510603/effectiveness-of-community-based-peer-support-for-mothers-to-improve-their-breastfeeding-practices-a-systematic-review-and-meta-analysis
#11
Prakash Shakya, Mika Kondo Kunieda, Momoko Koyama, Sarju Sing Rai, Moe Miyaguchi, Sumi Dhakal, Su Sandy, Bruno Fokas Sunguya, Masamine Jimba
METHODS: We searched for evidence regarding community-based peer support for mothers in databases, such as PubMed/MEDLINE, the Cochrane Library, CINAHL, Web of Science, SocINDEX, and PsycINFO. We selected three outcome variables for breastfeeding practices, namely, exclusive breastfeeding duration, breastfeeding within the first hour of life, and prelacteal feeding. We conducted meta-analyses of the included randomized controlled trials and quasi-experimental studies. RESULTS: For our review, we selected 47 articles for synthesis out of 1,855 retrieved articles...
2017: PloS One
https://www.readbyqxmd.com/read/28507327/pde3-inhibitor-and-egcg-combination-treatment-suppress-cancer-stem-cell-properties-in-pancreatic-ductal-adenocarcinoma
#12
Motofumi Kumazoe, Mika Takai, Shun Hiroi, Chieri Takeuchi, Maasa Yamanouchi, Takashi Nojiri, Hiroaki Onda, Jaehoon Bae, Yuhui Huang, Kanako Takamatsu, Shuya Yamashita, Shuhei Yamada, Kenji Kangawa, Takashi Takahashi, Hiroshi Tanaka, Hirofumi Tachibana
Recurrence following chemotherapy is observed in the majority of patients with pancreatic ductal adenocarcinoma (PDAC). Recent studies suggest that cancer stem cells (CSCs) may be involved in PDAC recurrence and metastasis. However, an efficient approach to targeting pancreatic CSCs remains to be established. Here we show that in cancer cells overexpressing the 67-kDa laminin receptor (67LR)-dependent cyclic GMP (cGMP) inducer, epigallocatechin-3-O-gallate (EGCG) and a phosphodiesterase 3 (PDE3) inhibitor in combination significantly suppressed the Forkhead box O3 and CD44 axis, which is indispensable for the CSC properties of PDAC...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28507102/foxo3-pgc-1%C3%AE-signaling-axis-is-essential-for-cancer-stem-cell-properties-of-pancreatic-ductal-adenocarcinoma
#13
Motofumi Kumazoe, Mika Takai, Shun Hiroi, Chieri Takeuchi, Mai Kadomatsu, Takashi Nojiri, Hiroaki Onda, Jaehoon Bae, Yuhui Huang, Kanako Takamatsu, Shuya Yamashita, Kenji Kangawa, Hirofumi Tachibana
In 95% of patients with pancreatic ductal adenocarcinoma (PDAC), recurrence is observed following chemotherapy. Findings from several studies have indicated that cancer stem cells (CSCs) are resistant to anti-cancer agents and may be involved in cancer recurrence and metastasis. The CD44 protein is a major CSC marker, and CD44 also plays an indispensable role in the CSC properties in several cancers, including pancreatic cancer; however, no clinical approach exists to inhibit CD44 activity. Here, we have performed knockin/knock down experiments and we demonstrate that the forkhead box O3 (FOXO3)/liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK)/PPAR-γ co-activator-1β (PGC- 1β)/pyruvate dehydrogenase -A1 (PDHA1) pathway is essential for CD44 expression and CSC properties...
May 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28505024/autonomic-nervous-system-pretransplant-malfunction-is-a-powerful-predictor-of-survival-after-allogeneic-hematopoietic-cell-transplantation
#14
Takahiko Nakane, Mika Nakamae, Hideo Koh, Mitsutaka Nishimoto, Yasuhiro Nakashima, Asao Hirose, Masayuki Hino, Hirohisa Nakamae
BACKGROUND: Autonomic nervous system function indexed by heart rate variability (HRV) has shown prognostic value for mortality in various cardiovascular and noncardiovascular diseases including cancer. The purpose of this study was to evaluate an association between HRV and outcomes of allogeneic hematopoietic cell transplantation (allo-HCT) METHODS: We prospectively measured HRV as a surrogate pretransplant marker of autonomic nervous system activity in consecutive allo-HCTs with hematological diseases...
May 13, 2017: Transplantation
https://www.readbyqxmd.com/read/28504807/occupational-class-and-working-beyond-the-retirement-age-a-cohort-study
#15
Marianna Virtanen, Tuula Oksanen, Jaana Pentti, Jenni Ervasti, Jenny Head, Sari Stenholm, Jussi Vahtera, Mika Kivimäki
Objectives The aim of this study was to examine occupational class differences in working more than six months beyond the mandatory retirement age and factors that may contribute to these differences. Methods The study comprised a prospective cohort study of a total of 5331 Finnish municipal employees (73% women) who were not on work disability pension and reached the age eligible for old-age pension in 2005-2011. Occupational class included four categories: managers and professionals, lower grade non-manual, skilled manual, and elementary occupations...
May 15, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/28504613/chlpmab-23-cancer-specific-human-mouse-chimeric-anti-podoplanin-antibody-exhibits-antitumor-activity-via-antibody-dependent-cellular-cytotoxicity
#16
Mika K Kaneko, Takuro Nakamura, Akiko Kunita, Masashi Fukayama, Shinji Abe, Yasuhiko Nishioka, Shinji Yamada, Miyuki Yanaka, Noriko Saidoh, Kanae Yoshida, Yuki Fujii, Satoshi Ogasawara, Yukinari Kato
Podoplanin is expressed in many cancers, including oral cancers and brain tumors. The interaction between podoplanin and its receptor C-type lectin-like receptor 2 (CLEC-2) has been reported to be involved in cancer metastasis and tumor malignancy. We previously established many monoclonal antibodies (mAbs) against human podoplanin using the cancer-specific mAb (CasMab) technology. LpMab-23 (IgG1, kappa), one of the mouse anti-podoplanin mAbs, was shown to be a CasMab. However, we have not shown the usefulness of LpMab-23 for antibody therapy against podoplanin-expressing cancers...
May 15, 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/28503696/ion-induced-molecular-growth-in-clusters-of-small-hydrocarbon-chains
#17
Michael Gatchell, Rudy Delaunay, Giovanna D'Angelo, Arkadiusz Mika, Kostiantyn Kulyk, Alicja Domaracka, Patrick Rousseau, Henning Zettergren, Bernd A Huber, Henrik Cederquist
We report on studies of collisions between 3 keV Ar(+) projectile ions and neutral targets of isolated 1,3-butadiene (C4H6) molecules and cold, loosely bound clusters of these molecules. We identify molecular growth processes within the molecular clusters that appears to be driven by knockout processes and that could result in the formation of (aromatic) ring structures. These types of reactions are not unique to specific projectile ions and target molecules, but will occur whenever atoms or ions with suitable masses and kinetic energies collide with aggregates of matter, such as carbonaceous grains in the interstellar medium or aerosol nanoparticles in the atmosphere...
May 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28503443/vascular-anomaly-in-the-levator-aponeurosis-of-neurofibromatosis-type-1
#18
Satoru Kase, Toshiya Shinohara, Mika Noda, Susumu Ishida, Manabu Kase
No abstract text is available yet for this article.
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28502498/mature-proprotein-convertase-subtilisin-kexin-type-9-coronary-atheroma-burden-and-vessel-remodeling-in-heterozygous-familial-hypercholesterolemia
#19
Yu Kataoka, Mariko Harada-Shiba, Kazuhiro Nakao, Takahiro Nakashima, Shoji Kawakami, Masashi Fujino, Tomoaki Kanaya, Toshiyuki Nagai, Yoshio Tahara, Yasuhide Asaumi, Mika Hori, Masatsune Ogura, Yoichi Goto, Teruo Noguchi, Satoshi Yasuda
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9), an important contributor to low-density lipoprotein metabolism in heterozygous familial hypercholesterolemia (HeFH), exhibits direct proatherogenic effects. PCSK9 circulates as mature and furin-cleaved forms, which differ in its biological activity. However, it remains to be elucidated whether each PCSK9 subtype has different atherogenic properties. OBJECTIVE: To investigate the association of each PCSK9 subtype with coronary atherosclerosis in HeFH...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28502054/light-absorption-of-biomass-burning-and-vehicle-emission-sourced-carbonaceous-aerosols-of-the-tibetan-plateau
#20
Zhaofu Hu, Shichang Kang, Chaoliu Li, Fangping Yan, Pengfei Chen, Shaopeng Gao, Zhiyong Wang, Yulan Zhang, Mika Sillanpää
Carbonaceous aerosols over the Tibetan Plateau originate primarily from biomass burning and vehicle emissions (BB and VEs, respectively). The light absorption characteristics of these carbonaceous aerosols are closely correlated with the burning conditions and represent key factors that influence climate forcing. In this study, the light absorption characteristics of elemental carbon (EC) and water-soluble organic carbon (WSOC) in PM2.5 (fine particulate matter smaller than 2.5 μm) generated from BB and VEs were investigated over the Tibetan Plateau (TP)...
May 14, 2017: Environmental Science and Pollution Research International
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