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Diabetes Screening

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https://www.readbyqxmd.com/read/29050400/metformin-reverses-trap1-mutation-associated-alterations-in-mitochondrial-function-in-parkinson-s-disease
#1
Julia C Fitzgerald, Alexander Zimprich, Daniel A Carvajal Berrio, Kevin M Schindler, Brigitte Maurer, Claudia Schulte, Christine Bus, Anne-Kathrin Hauser, Manuela Kübler, Rahel Lewin, Dheeraj Reddy Bobbili, Lisa M Schwarz, Evangelia Vartholomaiou, Kathrin Brockmann, Richard Wüst, Johannes Madlung, Alfred Nordheim, Olaf Riess, L Miguel Martins, Enrico Glaab, Patrick May, Katja Schenke-Layland, Didier Picard, Manu Sharma, Thomas Gasser, Rejko Krüger
The mitochondrial proteins TRAP1 and HTRA2 have previously been shown to be phosphorylated in the presence of the Parkinson's disease kinase PINK1 but the downstream signalling is unknown. HTRA2 and PINK1 loss of function causes parkinsonism in humans and animals. Here, we identified TRAP1 as an interactor of HTRA2 using an unbiased mass spectrometry approach. In our human cell models, TRAP1 overexpression is protective, rescuing HTRA2 and PINK1-associated mitochondrial dysfunction and suggesting that TRAP1 acts downstream of HTRA2 and PINK1...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29048411/early-versus-6-12-week-postpartum-glucose-tolerance-testing-for-women-with-gestational-diabetes
#2
E B Carter, S Martin, L A Temming, G A Colditz, G A Macones, M G Tuuli
OBJECTIVE: The objective of this study is to estimate the accuracy of early oral glucose tolerance testing (GTT), to predict impaired glucose tolerance. STUDY DESIGN: This was a prospective cohort study. Women received an early 75 g 2 h GTT between postpartum days 2-4 and again 6-12 weeks postpartum. The ability of the early GTT to accurately detect impaired glucose tolerance and diabetes was assessed by calculating sensitivity, specificity, positive predictive value (PPV) and negative predictive values (NPVs)...
October 19, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29047326/integrating-chws-as-part-of-the-team-leading-diabetes-group-visits-a-randomized-controlled-feasibility-study
#3
Elizabeth M Vaughan, Craig A Johnston, Victor J Cardenas, Jennette P Moreno, John P Foreyt
Purpose The purpose of the study was to evaluate the feasibility of integrating Community Health Workers (CHWs) as part of the team leading diabetes group visits. Methods This was a randomized controlled study that integrated CHWs as part of the team leading diabetes group visits for low-income Hispanic adults (n = 50). Group visits met for 3 hours each month for a 6-month duration. Main measures included baseline and 6-month clinical outcomes (ie, A1C, lipids), concordance with 8 standard of care guidelines (ie, screens for cervical, breast, and colon cancer) from the US Preventive Task Force and American Diabetes Association, and participant acceptability...
October 1, 2017: Diabetes Educator
https://www.readbyqxmd.com/read/29045170/high-glucose-variability-in-hospitalized-patients-with-type-1-diabetes-mellitus
#4
Vikash Dadlani, Shrikant U Tamhane, Aidong Sun, Anu Sharma, Danae A Delivanis, Prabin Thapa, Ricky E Carter, Yogish C Kudva
BACKGROUND: Glucose variability (GV) has been increasingly (or more extensively) studied in patients with type 1 diabetes (T1D) in the ambulatory setting; limited data exist on GV in hospitalized patients with T1D. MATERIALS AND METHODS: Retrospective single center cohort study, we analyzed in-hospital glucose measurements to assess GV in 736 hospitalized patients in different units over a consecutive 5-year period of time. GV was assessed by mean blood glucose (BG), Average daily risk range (ADRR), high BG index, and low BG index...
October 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29044550/proliferative-diabetic-retinopathy-characterization-based-on-fractal-features-evaluation-on-a-publicly-available-data-set
#5
José Ignacio Orlando, Karel van Keer, João Barbosa Breda, Hugo Luis Manterola, Matthew B Blaschko, Alejandro Clausse
PURPOSE: Diabetic retinopathy (DR) is one of the most widespread causes of preventable blindness in the world. The most dangerous stage of this condition is proliferative DR (PDR), in which the risk of vision loss is high and treatments are less effective. Fractal features of the retinal vasculature have been previously explored as potential biomarkers of DR, yet the current literature is inconclusive with respect to their correlation with PDR. In this study we experimentally assess their discrimination ability to recognize PDR cases...
October 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/29044172/circulating-mir-19b-and-mir-181b-are-potential-biomarkers-for-diabetic-cardiomyopathy
#6
Camila Uribe Copier, Luis León, Mauricio Fernández, David Contador, Sebastián D Calligaris
Diabetic cardiomyopathy is characterized by metabolic changes in the myocardium that promote a slow and silent dysfunction of muscle fibers, leading to myocardium remodelling and heart failure, independently of the presence of coronary artery diseases or hypertension. At present, no imaging methods allow an early diagnosis of this disease. Circulating miRNAs in plasma have been proposed as biomarkers in the prognosis of several cardiac diseases. This study aimed to determine whether circulating miRNAs could be potential biomarkers of diabetic cardiomyopathy...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043592/factors-associated-with-surveillance-adenoma-and-sessile-serrated-polyp-detection-rates
#7
Jennifer K Maratt, Joseph Dickens, Philip S Schoenfeld, Grace H Elta, Kenya Jackson, Daniel Rizk, Christine Erickson, Stacy B Menees
BACKGROUND: Adenoma detection rate (ADR) and sessile serrated polyp detection rate (SSPDR) data in surveillance colonoscopy are limited. AIMS: Our aim was to determine surveillance ADR and SSPDR and identify associated predictors. METHODS: A retrospective review of subjects who underwent surveillance colonoscopy for adenoma and/or SSP at an academic center was performed. The following exclusion criteria were applied: prior colonoscopy ≤ 3 years, incomplete examination, or another indication for colonoscopy...
October 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29042249/prevalence-and-biochemical-risk-factors-of-diabetic-peripheral-neuropathy-with-or-without-neuropathic-pain-in-taiwanese-adults-with-type-2-diabetes-mellitus
#8
Yen-Wei Pai, Ching-Heng Lin, I-Te Lee, Ming-Hong Chang
AIMS: To investigate the prevalence and risk factors for diabetic peripheral neuropathy with or without neuropathic pain in Taiwanese. METHODS: A cross-sectional, hospital-based observational study was conducted. We enrolled 2837 adults with type 2 diabetes mellitus. Diabetic peripheral neuropathy with or without pain were diagnosed using 2 validated screening tools, namely the Michigan Neuropathy Screening Instrument and Douleur Neuropathique 4 questionnaire. RESULTS: In our sample, 2233 participants had no neuropathy, 476 had diabetic peripheral neuropathy without pain, and 128 had diabetic peripheral neuropathy with neuropathic pain, representing an overall diabetic peripheral neuropathy prevalence of 21...
September 28, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29042060/australian-general-practitioners-initiate-statin-therapy-primarily-on-the-basis-of-lipid-levels-new-zealand-general-practitioners-use-absolute-risk
#9
REVIEW
Chris Schilling, Josh Knight, Duncan Mortimer, Dennis Petrie, Philip Clarke, John Chalmers, Andrew Kerr, Rod Jackson
OBJECTIVES: To compare the determinants of initial statin prescribing between New Zealand and Australia. New Zealand has a system-wide absolute risk-based approach to primary care cardiovascular disease (CVD) management, while Australia has multiple guidelines. METHOD: Classification and Regression Tree (CART) analysis of two observational studies of primary care CVD management from New Zealand (PREDICT-CVD) and Australia (AusHeart). Over 80% of eligible New Zealanders have been screened for CVD risk...
October 10, 2017: Health Policy
https://www.readbyqxmd.com/read/29041796/prevalence-of-eye-pathology-in-a-group-of-diabetic-patients-at-national-district-hospital-outpatient-department-in-bloemfontein-south-africa
#10
Joleen P Cairncross, Wilhelm J Steinberg, Mathys J Labuschagne
BACKGROUND: Diabetic retinopathy is the third most common cause of blindness after cataracts and glaucoma in South Africa. Primary healthcare interventions providing eye care services play an important role in preventing complications. AIM: To determine the prevalence of eye pathology in a group of diabetic patients at National District Hospital by screening for diabetes-associated ocular pathology. SETTING: Outpatients Department run by Department of Family Medicine at National District Hospital in Bloemfontein from June to July 2014...
September 27, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/29038789/diosgenin-a-novel-aldose-reductase-inhibitor-attenuates-the-galactosemic-cataract-in-rats
#11
Lixia Ji, Lixia Cheng, Zhihong Yang
OBJECTIVE: To seek efficient aldose reductase inhibitors (ARIs) with excellent in vitro and in vivo biological activities against rat galactosemic cataract. METHODS: The method was firstly optimized to screen strong ARIs from nonoriented synthetic compounds and natural extracts. Then, diosgenin was assessed on osmotic expansion of primarily cultured lens epithelial cells (LECs) induced by galactose (50 mM). Diosgenin was administered to galactosemic rats by oral (100 and 200 mg/kg) or direct drinking (0...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29038580/a-novel-library-of-arylketones-as-potential-inhibitors-of-%C3%AE-glucosidase-their-design-synthesis-in-vitro-and-in-vivo-studies
#12
Tania Luthra, Rahul Agarwal, Mamidala Estari, Uma Adepally, Subhabrata Sen
α-glucosidase is an essential enzyme located at the brush border of intestines. It is an important therapeutic target for type II diabetes. Herein we have designed a library of novel α-arylketones as inhibitors of α-glucosidase (yeast origin) via scaffold hopping and bioisosteric modification of known inhibitors of α-glucosidase. The design was validated through molecular docking that revealed strong binding interactions of the newly designed compounds against α-glucosidase. A library comprising of 15 compounds was synthesized in a combinatorial fashion, where the advanced amide intermediates were accessed through "shot gun" synthesis...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037900/autoimmune-comorbidity-in-chronic-spontaneous-urticaria-a-systematic-review
#13
REVIEW
Pavel Kolkhir, Elena Borzova, Clive Grattan, Riccardo Asero, Dmitry Pogorelov, Marcus Maurer
Background and Objective Numerous autoimmune diseases (AIDs) have been linked to chronic spontaneous urticaria (CSU). Here, we provide the first extensive and comprehensive evaluation of the prevalence of AIDs in patients with CSU and vice versa. METHODS: A Pubmed and Google Scholar search was performed to identify studies reporting the prevalence of various AIDs in CSU and vice versa published before April 2017. RESULTS: The prevalence of individual AIDs in CSU is increased (≥1% in most studies vs ≤1% in general population)...
October 13, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29037887/depression-and-related-risk-factors-among-patients-with-type-2-diabetes-mellitus-jazan-area-ksa-a-cross-sectional-study
#14
Osama B Albasheer, Mohammed S Mahfouz, Yahia Solan, Duaa A Khan, Mohammed A Muqri, Haneen A Almutairi, Ali M Alelyani, Hussain A Alahmed
PURPOSE: To determine the prevalence of depression and related risk factors among type 2 diabetes mellitus patients (T2DM) in Jazan area, Saudi Arabia. METHOD: A cross sectional, self-administered questionnaire study was conducted among T2DM patients in Jazan area, Saudi Arabia. A total of 385 patients were selected at randomly. The Patient Health Questionnaire (PHQ-9) was utilized to measure symptoms and signs of depression. RESULTS: The overall prevalence of depression among T2DM patients was 37...
September 28, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29037877/unbreakable-an-analysis-of-the-fragility-of-randomized-trials-that-support-diabetes-treatment-guidelines
#15
B Chase Kruse, B Matt Vassar
AIMS: To analyze the robustness of randomized controlled trials (RCTs) referenced in the American Diabetes Association's Standards of Medical Care in Diabetes-2017 using the Fragility Index (FI) and Fragility Quotient (FQ). METHODS: We performed a systematic survey of all RCTs referenced in the Standards of Medical Care in Diabetes-2017. One investigator screened for trials and then recorded data from them, including sample size per group, event rate per group, and the dichotomous outcome analyzed by trialists...
October 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29037219/meta-analysis-on-the-treatment-of-diabetic-foot-ulcers-with-autologous-stem-cells
#16
REVIEW
Jianming Guo, Alan Dardik, Kacey Fang, Ruixue Huang, Yongquan Gu
Over the last decade, many studies have indicated a therapeutic potential for treating diabetic lower extremity ulcers with autologous stem cells. The aim of the current study was to conduct a systematic review and meta-analysis of the treatment of diabetic foot ulcers (DFUs) with autologous stem cells. The search strategy included the Pubmed, EMBASE, Web of Science, and Cochrane's Library databases. The endpoint measured was the healing of DFUs.Six eligible randomized controlled trial (RCT) studies were screened from related published studies and reviewed for meta-analysis...
October 16, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29037162/feasibility-of-a-multi-modal-exercise-program-on-cognition-in-older-adults-with-type-2-diabetes-a-pilot-randomised-controlled-trial
#17
M L Callisaya, R M Daly, J E Sharman, D Bruce, T M E Davis, T Greenaway, M Nolan, R Beare, M G Schultz, T Phan, L C Blizzard, V K Srikanth
BACKGROUND: Type 2 Diabetes (T2D) is associated with increased risk of dementia. We aimed to determine the feasibility of a randomised controlled trial (RCT) examining the efficacy of exercise on cognition and brain structure in people with T2D. METHODS: A 6-month pilot parallel RCT of a progressive aerobic- and resistance-training program versus a gentle movement control group in people with T2D aged 50-75 years (n = 50) at the University of Tasmania, Australia...
October 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29035180/ten-year-trends-in-preventive-service-use-before-and-after-prostate-cancer-diagnosis-a-comparison-with-noncancer-controls
#18
Lauren P Wallner, Jeffrey M Slezak, Ronald K Loo, Roshan Bastani, Steven J Jacobsen
CONTEXT: Few studies have assessed the longer-term quality of preventive care in prostate cancer (PCa) survivors. OBJECTIVE: To compare the rates of preventive services among PCa survivors five years before and after diagnosis, to men without PCa. DESIGN: Men enrolled in Kaiser Permanente Southern California with newly diagnosed PCa (2002-2008) were matched 1:1 to men without a PCa diagnosis on age, race, and timing of prostate-specific antigen test (N = 31,180)...
2017: Permanente Journal
https://www.readbyqxmd.com/read/29032706/quality-and-predictors-of-diabetes-care-among-patients-with-schizophrenia-a-danish-nationwide-study
#19
Mette Jørgensen, Jan Mainz, Fabrizio Carinci, Reimar W Thomsen, Søren Paaske Johnsen
OBJECTIVE: Patients with schizophrenia have a high prevalence of diabetes, but data on diabetes care quality for these patients are limited. This nationwide study compared the quality of diabetes care among individuals with and without schizophrenia and identified predictors of care quality. METHODS: In a population-based cohort study, 83,813 individuals with diabetes seen at hospital outpatient clinics between 2005 and 2013, including 669 with comorbid schizophrenia, were identified from Danish registries...
October 16, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29032341/ethyl-acetate-fraction-of-eclipta-alba-a-potential-phytopharmaceutical-targeting-adipocyte-differentiation
#20
Abhishek Gupta, Ashok Kumar, Durgesh Kumar, Shiv Nandan, Kripa Shankar, Salil Varshney, Sujith Rajan, Ankita Srivastava, Sanchita Gupta, Sanjeev Kanojiya, T Narender, Anil Nilkanth Gaikwad
Natural products have always fascinated mankind for their miraculous properties. Eclipta alba (E. alba), a medicinal herb has long been used in traditional medicine for curing several pathologies. It has been shown to have anti-diabetic effect as well as hepato-protective activity. Here, in order to address metabolic derangements, the study was designed to evaluate the efficacy of E. alba and its fractions in adipogenesis inhibition and dyslipidemia. Of the crude extract and fractions screened, ethyl acetate fraction of E...
October 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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