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Diabetes Screening

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https://www.readbyqxmd.com/read/29239245/serum-and-plasma-amino-acids-as-markers-of-prediabetes-insulin-resistance-and-incident-diabetes
#1
C Gar, M Rottenkolber, C Prehn, J Adamski, J Seissler, A Lechner
Presently, routine screening misses many cases of prediabetes and early type 2 diabetes (T2D). Therefore, better biomarkers are needed for a simple and early detection of abnormalities of glucose metabolism and prediction of future T2D. Possible candidates for this include plasma or serum amino acids because glucose and amino acid metabolism are closely connected. This review presents the available evidence of this connectivity and discusses its clinical implications. First, we examine the underlying physiological, pre-analytical, and analytical issues...
December 14, 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29238904/anti-inflammatory-activity-of-anti-hyperlipidemic-drug-fenofibrate-and-its-phase-i-metabolite-fenofibric-acid-in-silico-in-vitro-and-in-vivo-studies
#2
G Shyam Prasad, P Govardhan, G Deepika, V Vakdevi, R B Sashidhar
Fenofibrate, an anti-hyperlipidemic drug and its phase-I biotransformed metabolite fenofibric acid, was studied for COX-1 (PDB ID: 3N8Y) and COX-2 (PDB ID: 1PXX) inhibition potentials in silico and in vitro for their effects on human recombinant COX-2 enzyme isolated from a Baculovirus expression system in sf21 cells (EC 1.14.99.1) using a conventional spectrophotometric assay. Furthermore, the compounds were also screened for their anti-inflammatory potentials in vivo using carrageenan-induced paw oedema method in Wistar rats...
December 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29238494/prevalence-of-diabetes-mellitus-and-its-relation-with-obesity-in-turaif-saudi-arabia-in-2017
#3
Reem Sebeh Alhazmi, Amer Ahmed Balla Ahmed, Maha Hazzaa Alshalan, Zuhur Dhaher Alfuhigi, Shoroq Faisal Alhazmi, Amjad Naif Aldughmi, Nada Naif Alshammari, Anwar Eid Alruwaili, Ghadah Saleem Alenezi, Taif Shayish Alanazi, Shouq Amjad Almadani
Background: The significant increase in the prevalence of obesity over past decades caused the concomitant rise in the incidence of glucose intolerance and diabetes. Objective: To determine the prevalence of diabetes among Saudi nationals in Turaif, Kingdom of Saudi Arabia and to examine the association between diabetes and obesity in the studied population. Methods: This study was conducted during the period from May 01 to May 31, 2017. Data was collected from 402 individuals aged between 6-63 years via a predesigned questionnaire covering medical history of diabetes, age and sex...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29237342/racial-ethnic-disparities-in-late-stage-colorectal-cancer-among-hispanics-and-non-hispanic-whites-of-new-mexico
#4
Melissa Gonzales, Fares Qeadan, Shiraz I Mishra, Ashwani Rajput, Richard M Hoffman
INTRODUCTION: Hispanics in New Mexico are diagnosed with more later-stage colorectal cancer (CRC) than non-Hispanic Whites (NHW). Our study evaluated the interaction of race/ethnicity and risk factors for later-stage III and IV CRC among patients in New Mexico. METHOD: CRC patients ages 30 to 75 years ( n = 163, 46% Hispanic) completed a survey on key explanatory clinical, lifestyle, preventive health, and demographic variables for CRC risk. Adjusted logistic regression models examined whether these variables differentially contributed to later-stage CRC among NHW versus Hispanics...
December 2017: Hispanic Health Care International: the Official Journal of the National Association of Hispanic Nurses
https://www.readbyqxmd.com/read/29234807/development-and-validation-of-a-deep-learning-system-for-diabetic-retinopathy-and-related-eye-diseases-using-retinal-images-from-multiethnic-populations-with-diabetes
#5
Daniel Shu Wei Ting, Carol Yim-Lui Cheung, Gilbert Lim, Gavin Siew Wei Tan, Nguyen D Quang, Alfred Gan, Haslina Hamzah, Renata Garcia-Franco, Ian Yew San Yeo, Shu Yen Lee, Edmund Yick Mun Wong, Charumathi Sabanayagam, Mani Baskaran, Farah Ibrahim, Ngiap Chuan Tan, Eric A Finkelstein, Ecosse L Lamoureux, Ian Y Wong, Neil M Bressler, Sobha Sivaprasad, Rohit Varma, Jost B Jonas, Ming Guang He, Ching-Yu Cheng, Gemmy Chui Ming Cheung, Tin Aung, Wynne Hsu, Mong Li Lee, Tien Yin Wong
Importance: A deep learning system (DLS) is a machine learning technology with potential for screening diabetic retinopathy and related eye diseases. Objective: To evaluate the performance of a DLS in detecting referable diabetic retinopathy, vision-threatening diabetic retinopathy, possible glaucoma, and age-related macular degeneration (AMD) in community and clinic-based multiethnic populations with diabetes. Design, Setting, and Participants: Diagnostic performance of a DLS for diabetic retinopathy and related eye diseases was evaluated using 494 661 retinal images...
December 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29234301/balance-screening-of-vestibular-function-in-subjects-aged-4-years-and-older-a-living-laboratory-experience
#6
María Carolina Bermúdez Rey, Torin K Clark, Daniel M Merfeld
To better understand the various individual factors that contribute to balance and the relation to fall risk, we performed the modified Romberg Test of Standing Balance on Firm and Compliant Support, with 1,174 participants between 4 and 83 years of age. This research was conducted in the Living Laboratory® at the Museum of Science, Boston. We specifically focus on balance test condition 4, in which individuals stand on memory foam with eyes closed, and must rely on their vestibular system; therefore, performance in this balance test condition provides a proxy for vestibular function...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29231926/predictors-of-physical-fitness-among-southwestern-native-american-adolescents-at-risk-for-diabetes
#7
M D Ehrhart, V Shah, L Colip, P Sandy, D Ghahate, J Bobelu, T Faber, M R Burge
The prevalence of obesity is increasing among children nationally. Native American children from Zuni Pueblo appear to be at increased risk for obesity, which also increases the risk for the metabolic syndrome, diabetes, and cardiovascular disease. While exercise and physical fitness can prevent or forestall these developments, predictors of physical fitness in this population are unknown. Forty-seven Native American adolescents completed four aspects of the Presidential Fitness Challenge (push-ups, sit-ups, step-ups, and timed walking) during screening for another study, and fitness was empirically summarized with a Presidential Fitness Index...
2017: J Pediatr Endocrinol (Jersey City)
https://www.readbyqxmd.com/read/29230866/utility-of-hba1c-and-fasting-plasma-glucose-for-screening-of-type-2-diabetes-a-meta-analysis-of-full-roc-curves
#8
A Hoyer, W Rathmann, O Kuss
AIMS: There is still debate on the optimal threshold for population-based screening of diabetes (diagnosed by the oral glucose tolerance test) using tests like HbA1c or fasting plasma glucose. Meta-analyses provide meaningful input in such situations. The aim of this article is to perform a meta-analysis that includes the complete information reported in the individual studies of two existing systematic reviews. METHODS: We screened the individual studies from two systematic reviews and reconstructed the full four-fold tables for every reported threshold...
December 12, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29230420/glycaemic-control-after-metformin-discontinuation-in-diabetic-patients-with-a-declining-renal-function
#9
Theresa Leyco, Davin Ryanputra, Ray Peh, Alexphil Ponce, Chin Meng Khoo
Metformin is contraindicated in diabetic patients with declining renal function. This study examined the glycaemic control in diabetic patients with chronic kidney disease when metformin was discontinued. This was a retrospective study. We screened 2032 diabetic patients who attended the Diabetes Clinic at a tertiary hospital between 1 September 2014 and 30 September 2015. We analyzed the data on 69 patients whom metformin was discontinued due to declining renal function and had a complete 6-month follow-up...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29228975/prediabetes-and-cardiovascular-complications-study-paccs-international-collaboration-4%C3%A2-years-summary-and-future-direction
#10
E U Nwose, R S Richards, P T Bwititi, E O Igumbor, E J Oshionwu, K Okolie, I C Onyia, A Pokhrel, P Gyawali, J N Okuzor, V M Oguoma, F W Gardiner, L Wang
OBJECTIVE: The prediabetes and cardiovascular complications studies proposes to develop a screening protocol for diabetes cardiovascular risk, and strategies for holistic management amongst others. Over 500 participants were recruited in the first 2 years of rural community research screening. Specific for this report, various published findings were reviewed. The objective is to summarize research outcomes and itemize limitations as they constitute basis of future directions. RESULTS: Affordability and availability are major confounding behavioural change wheel factors in the rural community...
December 11, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29228820/associations-between-depressive-symptomatology-and-neurocognitive-impairment-in-hiv-aids
#11
Sarah Tymchuk, Daniela Gomez, Noshin Koenig, M John Gill, Esther Fujiwara, Christopher Power
OBJECTIVE: Mood disorders and neurocognitive impairments are debilitating conditions among patients with HIV/AIDS. How these comorbidities interact and their relationships to systemic factors remain uncertain. Herein, we investigated factors contributing to depressive symptomatology (DS) in a prospective cohort of patients with HIV/AIDS in active care that included neuropsychological assessment. METHODS: Among patients with HIV/AIDS receiving combination antiretroviral therapy (cART) and ongoing clinical assessments including measures of sleep, health-related quality of life (HQoL), neuropsychological testing, and mood evaluation (Patient Health Questionnaire-9 [PHQ-9]) were performed...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29228578/association-of-single-nucleotide-polymorphisms-in-the-rage-gene-and-its-gene-environment-interactions-with-diabetic-nephropathy-in-chinese-patients-with-type-2-diabetes
#12
Ying Zhang, Nan Jia, Feng Hu, Naijun Fan, Xiaohua Guo, Han Du, Changlin Mei, Chunfang Gao
Aims: To investigate the association of several single nucleotide polymorphisms (SNPs) within RAGE gene and additional gene- smoking interaction with diabetic nephropathy (DN) risk in Chinese patients with type 2 diabetes mellitus (T2DM). Methods: A total of 865 participants (570 males, 295 females) were selected, including 430 T2DM complicated DN patients and 435 controls (T2DM patients without DN). Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and smoking...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227822/automated-retinal-health-diagnosis-using-pyramid-histogram-of-visual-words-and-fisher-vector-techniques
#13
Joel E W Koh, Eddie Y K Ng, Sulatha V Bhandary, Yuki Hagiwara, Augustinus Laude, U Rajendra Acharya
Untreated age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma may lead to irreversible vision loss. Hence, it is essential to have regular eye screening to detect these eye diseases at an early stage and to offer treatment where appropriate. One of the simplest, non-invasive and cost-effective techniques to screen the eyes is by using fundus photo imaging. But, the manual evaluation of fundus images is tedious and challenging. Further, the diagnosis made by ophthalmologists may be subjective...
December 5, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29227571/comparative-effectiveness-of-metformin-monotherapy-in-extended-release-and-immediate-release-formulations-for-the-treatment-of-type-2-diabetes-in-treatment-na%C3%A3-ve-chinese-patients-analysis-of-results-from-the-consent-trial
#14
Linong Ji, Jing Liu, Jing Yang, Yufeng Li, Li Liang, Dalong Zhu, Quanmin Li, Tianrong Ma, Haiyan Xu, Yanlan Yang, Jiaoe Zeng, Bo Feng, Shen Qu, Yiming Li, Lizhen Ma, Shanshan Lin, Jianping Wang, Wei Li, Weihong Song, Xiaoxing Li, Yong Luo, Shugang Xi, Mei Lin, Yu Liu, Zerong Liang
AIMS: Metformin treatment for type 2 diabetes (T2DM) can be limited by gastrointestinal (GI) adverse events (AEs), resulting in treatment discontinuation. We investigated whether once-daily metformin extended release (XR) is superior in terms of GI tolerability, with non-inferior efficacy, compared with thrice-daily metformin immediate release (IR) in treatment-naïve Chinese patients with T2DM. MATERIALS AND METHODS: This prospective, open-label, randomized, multicenter, phase IV interventional study enrolled Chinese T2DM patients to receive either metformin XR or metformin IR with a 2-week screening period, 16-week treatment period, and 2-week follow-up period without treatment...
December 11, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29227260/factors-associated-with-post-stroke-fatigue-during-the-second-half-year-after-stroke
#15
M Delva, N Lytvynenko, I Delva
Post-stroke fatigue (PSF) is a common and often debilitating sequel of both ischemic and hemorrhagic strokes Aim - identify socio-demographic, personal and psychological factors associated with different PSF domains over the second half year after stroke occurrence. There were examined patients consequently in definite time points: at 6 months (156 patients), at 9 months (139 patients) and at 12 months (128 patients) after ischemic or hemorrhagic strokes. Global PSF and certain PSF domains (physical, mental, motivational, activity-related) were measured by multidimensional fatigue inventory-20 scale...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29226646/comparison-of-citrate-buffer-with-sodium-fluoride-as-additives-in-determining-glycemia
#16
Maria de Toro-Crespo, Jose M Maesa-Marquez, Victor Sanchez-Margalet, Concepcion Gonzalez-Rodriguez, Patricia Fernandez-Riejos
BACKGROUND: The objectives of this study are to compare the effect of sodium fluoride and citrate on the stability of glucose in samples maintained at room temperature up to three hours, and to assess the clinical impact in the O'Sullivan test results after changing the additives in the collecting tubes. METHODS: The selected population was pregnant women between the 24th and 28th week of gestation, who were at the health center to undergo the O'Sullivan test as part of the screening program for GDM (gestacional diabetes mellitus)...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29225791/recent-advances-in-the-management-and-understanding-of-diabetic-retinopathy
#17
REVIEW
Matthew Powers, Margaret Greven, Robert Kleinman, Quan Dong Nguyen, Diana Do
Despite recent advances in the diagnosis and treatment of diabetic retinopathy, this complication remains a steadfast challenge to patients and physicians. This review summarizes recent progress in the diagnosis and management of diabetic retinopathy, including automated screening, optical coherence tomography, control of systemic risk factors, surgical techniques, laser treatment, and pharmaceutical treatment, including vascular endothelial growth factor inhibitors. Recent advances in pharmaceutical treatments, in particular, hold strong promise of halting and sometimes reversing the disease process...
2017: F1000Research
https://www.readbyqxmd.com/read/29225575/investigation-of-naturally-occurring-single-nucleotide-variants-in-human-taar1
#18
Jessica Mühlhaus, Juliane Dinter, Sabine Jyrch, Alexander Teumer, Simon F Jacobi, Georg Homuth, Peter Kühnen, Susanna Wiegand, Annette Grüters, Henry Völzke, Klemens Raile, Gunnar Kleinau, Heiko Krude, Heike Biebermann
Activation of trace amine-associated receptor 1 (TAAR1) in endocrine pancreas is involved in weight regulation and glucose homeostasis. The purpose of this study was the identification and characterization of potential TAAR1 variants in patients with overweight/obesity and disturbed glucose homeostasis. Screening for TAAR1 variants was performed in 314 obese or overweight patients with impaired insulin secretion. The detected variants were functionally characterized concerning TAAR1 cell surface expression and signaling properties and their allele frequencies were determined in the population-based Study of Health in Pomerania (SHIP)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29225471/glucose-tolerance-testing-and-anthropometric-comparisons-among-rural-residents-of-kyiv-region-investigating-the-possible-effect-of-childhood-starvation-a-community-based-study
#19
Mykola D Khalangot, Volodymir A Kovtun, Nadia V Okhrimenko, Vitaly G Gurianov, Victor I Kravchenko
A relationship between childhood starvation and type 2 diabetes mellitus (T2D) in adulthood was previously indicated. Ukraine suffered a series of artificial famines between 1921 and 1947. Famines of 1932 to 1933 and 1946 were most severe among them. Long-term health consequences of these famines remain insufficiently investigated. Type 2 diabetes mellitus screening was conducted between June 2013 and December 2014. A total of 198 rural residents of Kyiv region more than 44 years of age, not registered as patients with T2D, were randomly selected...
2017: Nutrition and Metabolic Insights
https://www.readbyqxmd.com/read/29225096/triglycerides-and-glycated-hemoglobin-for-screening-insulin-resistance-in-obese-patients
#20
Guilaine Boursier, Ariane Sultan, Nicolas Molinari, Laurent Maimoun, Catherine Boegner, Marion Picandet, Nils Kuster, Anne-Sophie Bargnoux, Stéphanie Badiou, Anne-Marie Dupuy, Jean-Paul Cristol, Antoine Avignon
OBJECTIVE: Assessment of insulin resistance (IR) is essential in non-diabetic patients with obesity. Thus study aims to identify the best determinants of IR and to propose an original approach for routine assessment of IR in obesity. DESIGN AND PATIENTS: All adult with obesity defined by a body mass index ≥30kg/m2, evaluated in the Nutrition Department between January 2010 and January 2015 were included in this cross-sectional study. Patients with diabetes were excluded...
December 7, 2017: Clinical Biochemistry
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