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https://www.readbyqxmd.com/read/28724324/strong-impact-of-ethnicity-on-effectiveness-of-the-first-trimester-maternal-serum-screen-of-fetal-down-syndrome
#1
Thitikarn Lerthiranwong, Chanane Wanapirak, Supatra Sirichotiyakul, Fuanglada Tongprasert, Kasemsri Srisupundit, Suchaya Luewan, Theera Tongsong
OBJECTIVES: To compare the effectiveness of first trimester maternal serum screening (MSS) for fetal Down syndrome among Thai women between the method using Caucasian reference ranges with racial factor correction (CRR-RC) and that using Thai reference ranges (TRR). METHODS: A prospective database of MSS was accessed. The levels of PAPP-A and beta-hCG were calculated to determine their MoMs (multiple of medians) by two methods: 1) CRR-RC for Asian women and 2) TRR...
July 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28707830/-patients-with-metal-on-metal-hip-arthroplasty-evaluation-and-management-of-complications
#2
Olivier Guyen, Christophe Tissot
The potentially severe complications related to metal-on-metal (MoM) hip replacements have led to a dramatic decrease of their use. Large diameter heads are more likely to fail than smaller diameters, but complications have been described even with « small » diameters. Therefore, monitoring of MoM arthroplasties is mandatory. This includes physical examination, X-Rays, metal ion levels, and potentially cross-sectional imaging. Despite pathophysiology of adverse reactions to metal debris (ARMD) is better understood, their evolution and the potential systemic complications remain unclear...
December 14, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28706362/pregnancy-associated-plasma-protein-a-levels-in-late-first-trimester-pregnancies-with-small-for-gestational-age-neonates-a-prospective-case-control-study
#3
Rachna Agarwal, Radhika Kumari, Mohit Mehndiratta, Gita Radhakrishnan, M M A Faridi, Nilesh Chandra
OBJECTIVE: We aimed to investigate the association of pregnancy associated plasma protein A (PAPP-A) levels in late first trimester with small for gestational age (SGA) neonates and adverse pregnancy outcomes in a low-income setting. METHODS: The inclusion criteria were late first trimester (11-13 + 6 weeks) women with singleton and non-anomalous pregnancy. Enrolled participants were sampled for PAPP-A and prospectively followed up for delivery outcome and antenatal complications...
August 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28702381/importance-of-preclinical-evaluation-of-wear-in-hip-implant-designs-using-simulator-machines
#4
REVIEW
Rafael Mello Trommer, Márcia Marie Maru
Total hip arthroplasty (THA) is a surgical procedure that involves the replacement of the damaged joint of the hip by an artificial device. Despite the recognized clinical success of hip implants, wear of the articulating surfaces remains as one of the critical issues influencing performance. Common material combinations used in hip designs comprise metal-on-polymer (MoP), ceramic-on-polymer (CoP), metal-on-metal (MoM), and ceramic-on-ceramic (CoC). However, when the design of the hip implant is concerned besides the materials used, several parameters can influence its wear performance...
May 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28699417/comparison-of-metal-ion-concentrations-and-implant-survival-after-total-hip-arthroplasty-with-metal-on-metal-versus-metal-on-polyethylene-articulations
#5
Henrik Dahlstrand, André Stark, Marius C Wick, Lucas Anissian, Nils P Hailer, Rüdiger J Weiss
Background and purpose - Large metal-on-metal (MoM) articulations are associated with metal wear and corrosion, leading to increased metal ion concentrations and unacceptable revision rates. There are few comparative studies of 28-mm MoM articulations with conventional metal-on-polyethylene (MoP) couplings. We present a long-term follow-up of a randomized controlled trial comparing MoM versus MoP 28-mm articulations, focused on metal ions and implant survival. Patients and methods - 85 patients with a mean age of 65 years at surgery were randomized to a MoM (Metasul) or a MoP (Protasul) bearing...
July 12, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28695177/unusual-presentation-of-failed-metal-on-metal-total-hip-arthroplasty-with-features-of-neoplastic-process
#6
Robert P Runner, Briggs M Ahearn, George N Guild
Metal-on-metal (MoM) total hip arthroplasty (THA) is associated with increased incidence of failure from metallosis, adverse tissue reactions, and the formation of pseudotumors. This case highlights a 53-year-old female with an enlarging painful thigh mass 12 years status post MoM THA. Radiographs and advanced imaging revealed an atypical mass with cortical bone destruction and spiculation, concerning for periprosthetic malignancy. Open frozen section biopsy was performed before undergoing revision THA in a single episode of care...
June 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/28688018/current-pathologic-scoring-systems-for-metal-on-metal-tha-revisions-are-not-reproducible
#7
Christiaan Smeekes, Arjen H G Cleven, Bart C H van der Wal, Stefan V Dubois, Remigio W Rouse, Bastiaan F Ongkiehong, Ron Wolterbeek, Rob G H H Nelissen
BACKGROUND: The aseptic lymphocyte vasculitis-associated lesion (ALVAL) score and the modified Oxford ALVAL score are frequently used scoring methods to evaluate the morphologic features of periprosthetic tissues around metal-on-metal (MoM) hip implants. Except for the initial studies of these two morphology scoring methods, to our knowledge, no other studies have reported on intraclass correlation coefficient (ICC) values for interobserver reliability of these scoring methods. QUESTIONS/PURPOSES: Are the ALVAL and Oxford ALVAL scores reproducible? METHODS: The periprosthetic tissue of 37 revisions of 36 patients with failed MoM THAs were independently scored by three experienced pathologists using ALVAL and Oxford ALVAL scoring methods...
July 7, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28682613/synthesis-of-a-3-amino-2-3-dihydropyrid-4-one-and-related-heterocyclic-analogs-as-mechanism-based-inhibitors-of-bioa-a-pyridoxal-phosphate-plp-dependent-enzyme
#8
Carter G Eiden, Courtney C Aldrich
Amiclenomycin (ACM) is a chemically unstable antibiotic with selective activity against Mycobacterium tuberculosis (Mtb) due to mechanism-based inhibition of BioA, a pyridoxal 5'-phosphate (PLP) dependent aminotransferase that catalyzes the second step of biotin biosynthesis. The first-generation ACM analogue dihydro-2-pyridone 1 is semi-stable and maintains a similar bioactivation mechanism concluding with covalent labeling of the PLP cofactor. To improve on 1, we report the synthesis of dihydro-4-pyranone 2, dihydro-4-pyridone 3 and dihydro-4-thiopyranone 13...
July 6, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28665536/mixed-methods-evaluation-of-participant-recruitment-and-retention-in-the-mom-power-parenting-intervention-program
#9
Lilia E Mucka, Carolyn J Dayton, Jamie Lawler, Rosalind Kirk, Emily Alfafara, Melisa M Schuster, Nicole Miller, Julie Ribaudo, Katherine Lisa Rosenblum, Maria Muzik
Parenting group success begins with attendance. Using archival pilot data from 99 mothers who enrolled in the Mom Power (MP) parenting intervention, this study sought to understand the factors that influenced participant engagement and retention. MP is a group-based, early intervention program grounded in attachment theory that utilizes motivational interviewing as a core component to enhance program engagement. Study aims were to qualitatively describe the reasons why mothers were interested in participating in the program, including what they hoped to gain from the experience, and to quantitatively examine the extent to which attendance was associated with demographic, experiential, and psychosocial factors...
July 2017: Infant Mental Health Journal
https://www.readbyqxmd.com/read/28653409/a-time-adjusted-cortisol-cut-off-can-reduce-referral-rate-for-synacthen-stimulation-test-whilst-maintaining-diagnostic-performance
#10
Suzanne Brown, Narelle Hadlow, Imran Badshah, David Henley
OBJECTIVE: Cortisol cut-offs can predict requirement for Synacthen stimulation tests (SST). We assessed the performance of a standard cortisol cut-off (375 nmol/L) across the morning and compared this with a time-adjusted cut-off. DESIGN: Retrospective audit. PATIENTS: Community reference set (n=12 550) and SST patients (n=757). MEASUREMENTS: In the reference population time-specific cortisol medians were calculated and used to convert cortisol to time-adjusted Multiples of the Median (MoM)...
June 27, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28651087/effects-of-terrestrial-and-marine-organic-matters-on-deposition-of-dechlorane-plus-dp-in-marine-sediments-from-the-southern-yellow-sea-china-evidence-from-multiple-biomarkers
#11
Guoguang Wang, Jialin Peng, Ting Hao, Lijuan Feng, Qiaoling Liu, Xianguo Li
As an emerging halogenated organic contaminant, Dechlorane Plus (DP) was scarcely reported in marine environments, especially in China. In this work, 35 surface sediments and a sediment core were collected across the Southern Yellow Sea (SYS) to comprehensively explore the spatio-temporal distribution and possible migration pathway of DP. DP concentrations ranged from 14.3 to 245.5 pg/g dry weight in the surface sediments, displaying a seaward increasing trend with the high levels in the central mud zone. This spatial distribution pattern was ascribed to that fine particles with the elevated DP levels were preferentially transported to the central mud zone under hydrodynamic forcing and/or via long-range atmospheric transportation and deposition...
June 23, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28647759/a-community-based-randomized-controlled-trial-of-mom-power-parenting-intervention-for-mothers-with-interpersonal-trauma-histories-and-their-young-children
#12
Katherine L Rosenblum, Maria Muzik, Diana M Morelen, Emily A Alfafara, Nicole M Miller, Rachel M Waddell, Melisa M Schuster, Julie Ribaudo
We conducted a study to evaluate the effectiveness of Mom Power, a multifamily parenting intervention to improve mental health and parenting among high-risk mothers with young children in a community-based randomized controlled trial (CB-RCT) design. Participants (N = 122) were high-risk mothers (e.g., interpersonal trauma histories, mental health problems, poverty) and their young children (age <6 years), randomized either to Mom Power, a parenting intervention (treatment condition), or weekly mailings of parenting information (control condition)...
June 25, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28640514/de-novo-abnormal-uteroplacental-circulation-in-the-third-trimester-pregnancy-outcome-and-pathological-implications
#13
Julia Binder, Caitriona Monaghan, Baskaran Thilaganathan, Silvia Carta, Asma Khalil
OBJECTIVE: Hypertensive disorders of pregnancy (HDP) are associated with impaired placentation, as evidenced by abnormal uterine artery (UtA) Doppler. UtA mean pulsatility index (PI) shows a progressive decline with gestational age (GA). However, previous studies have reported that a proportion of pregnancies demonstrate worsening of the UtA Doppler. The aim of this study was to investigate the incidence of HDP according to the change in the UtA mean PI between the second and third trimester...
June 22, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28632081/meeting-other-moms-lesbian-adoptive-mothers-relationships-with-other-parents-at-school-and-beyond
#14
Abbie E Goldberg, Reihonna L Frost, Melissa H Manley, Kaitlin A Black
Little research has examined the friendships of lesbian parents, especially within the context of children's schools. This study of 40 lesbian adoptive parents (20 couples) focused on their relationships with other parents in the school community and how sexual orientation, race, and class dynamics impacted these relationships. Half of the participants described friendships with parents at the school, sometimes in spite of demographic differences, whereas others felt disconnected due to these differences. Outside of school, most participants reported friendships with other lesbian/gay parents...
February 17, 2017: Journal of Lesbian Studies
https://www.readbyqxmd.com/read/28624818/maternal-subcutaneous-and-visceral-adipose-ultrasound-thickness-in-women-with-gestational-diabetes-mellitus-at-24-28-weeks-gestation
#15
Francesco D'Ambrosi, Francesca Crovetto, Enrico Colosi, Isabella Fabietti, Floriana Carbone, Beatrice Tassis, Silvia Motta, Alessandro Bulfoni, Luigi Fedele, Gabriele Rossi, Nicola Persico
OBJECTIVE: To compare the sonographic measurement of maternal subcutaneous and visceral adipose thickness between pregnant women with gestational diabetes mellitus (GDM) and patients with nondiabetic pregnancies. METHODS: Adipose thickness was measured by transabdominal ultrasound in pregnant women attending our antenatal clinics at 24-28 weeks' gestation. All patients underwent a 75-g oral glucose challenge as a diagnostic test for GDM. RESULTS: The study population comprised 56 women with a positive glucose challenge test and 112 nondiabetic pregnancies...
June 17, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28616704/metallic-ion-release-after-knee-prosthesis-implantation-a-prospective-study
#16
Adrien Lons, Sophie Putman, Gilles Pasquier, Henri Migaud, Elodie Drumez, Julien Girard
INTRODUCTION: Metal-on-metal (MoM) hip replacement bearings produce metallic ions that can cause health complications. Metallic release also occurs with other materials, but data on metallic ion levels after knee arthroplasty are sparse. We postulate that knee replacement generates elevating metallic ions (chromium (Cr), cobalt (Co) and titanium (Ti)) during the first year after implantation. PATIENTS AND METHODS: This ongoing prospective study included all patients who underwent the same type of knee arthroplasty between May and December 2013...
June 14, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28615939/effect-of-carbon-ion-implantation-on-the-tribology-of-metal-on-metal-bearings-for-artificial-joints
#17
Hironobu Koseki, Masato Tomita, Akihiko Yonekura, Takashi Higuchi, Sinya Sunagawa, Koumei Baba, Makoto Osaki
Metal-on-metal (MoM) bearings have become popular due to a major advantage over metal-on-polymer bearings for total hip arthroplasty in that the larger femoral head and hydrodynamic lubrication of the former reduce the rate of wear. However, concerns remain regarding adverse reactions to metal debris including metallosis caused by metal wear generated at the taper-head interface and another modular junction. Our group has hypothesized that carbon ion implantation (CII) may improve metal wear properties. The purpose of this study was to investigate the wear properties and friction coefficients of CII surfaces with an aim to ultimately apply these surfaces to MoM bearings in artificial joints...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28614251/analysis-of-down-syndrome-failed-to-be-diagnosed-after-prenatal-screening-a-multicenter-study
#18
MULTICENTER STUDY
Tao Jiang, Jie Ding, Xiao-Qing Zhang, Xiao-Juan Zhang, Bin Zhang, Ting Wang, Bin Yu
To analyze the characters of Down syndrome (DS) who failed to be diagnosed after prenatal screening and hope to be able to improve the programs of prenatal screening and reduce the missed diagnosis of DS. In this multicenter study, we collected the missed cases from 3 prenatal diagnosis centers and analyzed their characters. A total of 126 DS babies failed to be diagnosed after prenatal screening. Their mothers accepted the prenatal screening in second trimester. We collected the mothers' blood and detected the levels of alpha-fetoprotein (AFP) and the free beta subunit of human chorionic gonadotropin (fβhCG) by time-resolved fluoroimmunoassay...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28613385/expanded-conventional-first-trimester-screening
#19
Jonathan B Carmichael, Hsiao-Pin Liu, David Janik, Terrence W Hallahan, Kypros H Nicolaides, David A Krantz
OBJECTIVE: To determine the performance of a five (5) serum marker plus ultrasound screening protocol for T21, T18 and T13. METHOD: Specimens from 331 unaffected, 34 T21, 19 T18 and 8 T13 cases were analyzed for free Beta hCG, PAPP-A, AFP, PlGF and dimeric inhibin A (DIA). Gaussian distributions of MoM values were used to estimate modeled false positive and detection rates. RESULTS: For T21, at a 1/300 risk cut-off, detection rate of screening with all five serum markers along with nuchal translucency and nasal bone was 98% at a 1...
June 14, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28604182/the-magnitude-of-elevated-maternal-serum-human-chorionic-gonadotropin-and-pregnancy-complications
#20
Reuven Sharony, Oren Zipper, Keren Amichay, Amir Wiser, Debora Kidron, Tal Biron-Shental, Ron Maymon
This study assessed the correlation between the magnitude of the elevation in maternal serum human chorionic gonadotropin (MShCG) levels and pregnancy complications. Among 80,716 screened pregnancies, 120 with moderately elevated MShCG (3.00-5.99 MoM) were compared to 84 with extremely elevated MShCG >6.00 MoM. A control series of 120 women with normal MShCG (<3.00 MoM) were matched. Rates of intrauterine growth restriction, preterm labour, antepartum foetal death (APFD), pre-eclampsia, and placental abruption were analysed...
July 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
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