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https://www.readbyqxmd.com/read/28926825/fetal-growth-and-placental-growth-factor-umbilical-cord-blood-levels
#1
Zoe A Broere-Brown, Sarah Schalekamp-Timmermans, Vincent W V Jaddoe, Eric A P Steegers
OBJECTIVE: We assessed whether umbilical cord blood placental growth factor (PlGF) levels at delivery are associated with fetal growth. METHODS: From a prospective population-based cohort study we included 3,461 live singleton births. Fetal growth was assessed by birth weight, fetal growth pattern, and fetal growth restriction (FGR; decrease in growth between the second trimester and birth of ≥40 percentiles). In all analyses the highest PlGF multiple of the median (MoM) quintile was used as the reference category...
September 20, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28926382/blood-metal-ion-thresholds-to-identify-patients-with-metal-on-metal-hip-implants-at-risk-of-adverse-reactions-to-metal-debris-an-external-multicenter-validation-study-of-birmingham-hip-resurfacing-and-corail-pinnacle-implants
#2
Gulraj S Matharu, Fiona Berryman, Andrew Judge, Aleksi Reito, Jamie McConnell, Olli Lainiala, Stephen Young, Antti Eskelinen, Hemant G Pandit, David W Murray
BACKGROUND: The authors of recent studies have reported newly devised implant-specific blood metal ion thresholds to predict adverse reactions to metal debris (ARMD) in patients who have undergone unilateral or bilateral metal-on-metal (MoM) hip arthroplasty. These thresholds were most effective for identifying patients at low risk of ARMD. We investigated whether these newly devised blood metal ion thresholds could effectively identify patients at risk of ARMD after MoM hip arthroplasty in an external cohort of patients...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28923123/-a-machine-for-recreating-life-an-introduction-to-reproduction-on-film
#3
Jesse Olszynko-Gryn, Patrick Ellis
Reproduction is one of the most persistently generative themes in the history of science and cinema. Cabbage fairies, clones and monstrous creations have fascinated filmmakers and audiences for more than a century. Today we have grown accustomed not only to the once controversial portrayals of sperm, eggs and embryos in biology and medicine, but also to the artificial wombs and dystopian futures of science fiction and fantasy. Yet, while scholars have examined key films and genres, especially in response to the recent cycle of Hollywood 'mom coms', the analytic potential of reproduction on film as a larger theme remains largely untapped...
September 2017: British Journal for the History of Science
https://www.readbyqxmd.com/read/28921586/down-syndrome-maternal-serum-markers-in-oocyte-donation-and-other-assisted-reproductive-technologies
#4
Aurore Bonnin, Françoise Muller, Marie-Victoire Senat, Corinne Sault, Armelle Galland, Joëlle Taieb, Sophie Dreux, Jean Bouyer, Alexandra Benachi
OBJECTIVE: Because maternal serum markers (PAPP-A, hCGβ, and AFP) used for Down syndrome (DS) screening have been described as predictors of obstetrical complications and because assisted reproductive technology (ART) pregnancies are known to be at increased risk for obstetrical complications, it is unclear whether or not correction factors should be applied to the calculated risk of DS. The purpose of this study was to evaluate DS maternal serum markers in oocyte donation (OD) and ART pregnancies in comparison with natural pregnancies...
September 16, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28918024/antisense-oligonucleotide-mediated-removal-of-the-polyglutamine-repeat-in-spinocerebellar-ataxia-type-3-mice
#5
Lodewijk J A Toonen, Frank Rigo, Haico van Attikum, Willeke M C van Roon-Mom
Spinocerebellar ataxia type 3 (SCA3) is a currently incurable neurodegenerative disorder caused by a CAG triplet expansion in exon 10 of the ATXN3 gene. The resultant expanded polyglutamine stretch in the mutant ataxin-3 protein causes a gain of toxic function, which eventually leads to neurodegeneration. One important function of ataxin-3 is its involvement in the proteasomal protein degradation pathway, and long-term downregulation of the protein may therefore not be desirable. In the current study, we made use of antisense oligonucleotides to mask predicted exonic splicing signals, resulting in exon 10 skipping from ATXN3 pre-mRNA...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28913397/cardiac-transplant-due-to-metal-toxicity-associated-with-hip-arthroplasty
#6
Sheldon Moniz, Sean Hodgkinson, Piers Yates
Concerns regarding metal-on-metal (MoM) bearing couples in total hip arthroplasty are well documented in the literature with cobalt (Co) and chromium (Cr) toxicity causing a range of both local and systemic adverse reactions. We describe the case of a patient undergoing cardiac transplantation as a direct result of Co and Cr toxicity following a MoM hip replacement. Poor implant positioning led to catastrophic wear generating abundant wear particles leading to Co and Cr toxicity, metallosis, bony destruction, elevated metal ion levels, and adverse biological responses...
September 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/28910784/fetal-surgery-for-myelomeningocele-a-systematic-review-and-meta-analysis-of-outcomes-in-fetoscopic-versus-open-repair
#7
Sandra K Kabagambe, Guy W Jensen, Yue Julia Chen, Melissa A Vanover, Diana L Farmer
BACKGROUND/OBJECTIVES: The Management of Myelomeningocele (MMC) Study (MOMS) showed that prenatal repair of MMC resulted in improved neurological outcomes but was associated with high rates of obstetrical complications. This study compares outcomes of open and fetoscopic MMC repair. DATA SOURCES: PubMed and Embase studies reporting outcomes of fetal MMC repair published since the completion of the MOMS. RESULTS: We analyzed 11 studies and found no difference in mortality or the rate of shunt placement for hydrocephalus...
September 15, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28900863/metal-on-metal-hip-joint-prostheses-a-retrospective-case-series-investigating-the-association-of-systemic-toxicity-with-serum-cobalt-and-chromium-concentrations
#8
James H Ho, Jerrold B Leikin, Paul I Dargan, John R H Archer, David M Wood, Jeffrey Brent
INTRODUCTION: There have been concerns about prosthesis failure and the potential for systemic toxicity due to release of cobalt and chromium from metal-on-metal hip joint prostheses (MoM-HP). There is conflicting evidence on whether there is a correlation between higher cobalt and chromium concentrations and systemic toxicity. METHODS: We undertook a retrospective review of consecutive patients with MoM-HP referred for outpatient review in toxicology clinics in London, UK, and in the USA recorded in the Toxicology Investigators Consortium (ToxIC) Registry from June 2011 to June 2015...
September 12, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28900622/biomechanical-measurement-error-can-be-caused-by-fujifilm-thickness-a-theoretical-experimental-and-computational-analysis
#9
Ahmed Sarwar, Simli Srivastava, Chris Chu, Alan Machin, Emil H Schemitsch, Habiba Bougherara, Zahra S Bagheri, Radovan Zdero
This is the first study to quantify the measurement error due to the physical thickness of Fujifilm for several material combinations relevant to orthopaedics. Theoretical and experimental analyses were conducted for cylinder-on-flat indentation over a series of forces (750 and 3000 N), cylinder diameters (0 to 80 mm), and material combinations (metal-on-metal, MOM; metal-on-polymer, MOP; metal-on-bone, MOB). For the scenario without Fujifilm, classic Hertzian theory predicted the true line-type contact width as WO = {(8FDcyl)/(πLcyl)[(1 - νcyl(2))/Ecyl + (1 - νflat(2))/Eflat]}(1/2), where F is compressive force, Dcyl is cylinder diameter, Lcyl is cylinder length, νcyl and νflat are cylinder and flat Poisson's ratios, and Ecyl and Eflat are cylinder and flat elastic moduli...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28889785/validation-of-fetal-medicine-foundation-algorithm-for-prediction-of-preeclampsia-in-the-first-trimester-in-an-unselected-brazilian-population
#10
Guilherme Antonio Rago Lobo, Paulo Martin Nowak, Ana Paula Panigassi, Angélia Iara Felipe Lima, Edward Araujo Júnior, Luciano Marcondes Machado Nardozza, David Baptista Silva Pares
OBJECTIVE: To evaluate the predictive performance of the Fetal Medicine Foundation (FMF) algorithm for prediction of preeclampsia (PE) between 11 and 14 weeks of gestation in an unselected Brazilian population. METHODS: We conducted a prospective cohort study with 617 singleton pregnancies of unselected risk. Biophysical markers (mean pulsatility index, mean arterial pressure) and biochemical markers (placental growth factor (PLGF) and PAPP-A) were inserted into the FMF software and converted into multiples of the median (MoM)...
September 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28887488/the-chemical-form-of-metal-species-released-from-corroded-taper-junctions-of-hip-implants-synchrotron-analysis-of-patient-tissue
#11
Anna Di Laura, Paul D Quinn, Vasiliki C Panagiotopoulou, Harry S Hothi, Johann Henckel, Jonathan J Powell, Fitim Berisha, Fernanda Amary, J Fred W Mosselmans, John A Skinner, Alister J Hart
The mechanisms of metal release from the articulation at the head cup bearing and the tapered junctions of orthopaedic hip implants are known to differ and the debris generated varies in size, shape and volume. Significantly less metal is lost from the taper junction between Cobalt-Chromium-Molybdenum (CoCrMo) and Titanium (Ti) components (fretting-corrosion dominant mechanism), when compared to the CoCrMo bearing surfaces (wear-corrosion dominant mechanism). Corrosion particles from the taper junction can lead to Adverse Reactions to Metal Debris (ARMD) similar to those seen with CoCrMo bearings...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887024/are-trends-in-total-hip-arthroplasty-bearing-surface-continuing-to-change-2007-2015-usage-in-a-large-database-cohort
#12
Nicholas A Bedard, Robert A Burnett, David E DeMik, Yubo Gao, Steve S Liu, John J Callaghan
BACKGROUND: Bearing surface issues related to trunnionosis or metal-on-metal (MoM) articulations have likely impacted recent trends in bearing surface choice. The purpose of this study is to evaluate trends in total hip arthroplasty (THA) bearing surface use, including 2015 data, with respect to the date of operation and patient demographics. METHODS: The Humana dataset was reviewed from 2007 through 2015 to analyze bearing surface usage in primary THA. Four bearing surface types were identified by International Classification of Disease, 10th Revision codes and trended throughout the years: metal-on-polyethylene (MoP), ceramic-on-ceramic (CoC), ceramic-on-polyethylene (CoP), and MoM...
August 3, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28885839/co2-stimuli-responsive-injectable-block-copolymer-hydrogels-cross-linked-by-discrete-organoplatinum-ii-metallacycles-via-stepwise-post-assembly-polymerization
#13
Wei Zheng, Guang Yang, Nannan Shao, Li-Jun Chen, Bo Ou, Shu-Ting Jiang, Guosong Chen, Hai-Bo Yang
Supramolecular polymeric gels cross-linked by well-defined, discrete metal-organic macrocycles (MOMs) or metal-organic cages (MOCs) have become a prevailing topic within the field of supramolecular self-assembly. However, the realization of supramolecular polymeric hydrogels cross-linked by discrete organometallic architectures with good biocompatibility is still a great challenge. Herein, we present the successful preparation of CO2 stimuli-responsive, injectable block copolymer hydrogels cross-linked by discrete organoplatinum(II) metallacycles...
September 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28885647/10-year-results-of-the-birmingham-hip-resurfacing-a-non-designer-case-series
#14
Thomas J A Hunter, Thomas S Moores, David Morley, Gopikanthan Manoharan, Simon G Collier, Phillip J Shaylor
INTRODUCTION: Recent controversies surrounding metal-on-metal (MoM) hip resurfacing has led to a substantial decline in its use. Despite this, there is good evidence to support the use of specific implants in select patients. PATIENTS AND METHODS: A retrospective analysis of Birmingham Hip Resurfacing (BHR) patients with a minimum of 10 years follow-up was performed. Functional scoring was performed with the Oxford Hip Score (OHS) and failure was defined as revision for any cause...
September 5, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28882994/synthesis-of-mixed-hypermetallic-oxide-baoca-from-laser-cooled-reagents-in-an-atom-ion-hybrid-trap
#15
Prateek Puri, Michael Mills, Christian Schneider, Ionel Simbotin, John A Montgomery, Robin Côté, Arthur G Suits, Eric R Hudson
Hypermetallic alkaline earth (M) oxides of formula MOM have been studied under plasma conditions that preclude insight into their formation mechanism. We present here the application of emerging techniques in ultracold physics to the synthesis of a mixed hypermetallic oxide, BaOCa(+) These methods, augmented by high-level electronic structure calculations, permit detailed investigation of the bonding and structure, as well as the mechanism of its formation via the barrierless reaction of Ca ((3)PJ) with BaOCH3(+) Further investigations of the reaction kinetics as a function of collision energy over the range 0...
September 7, 2017: Science
https://www.readbyqxmd.com/read/28878368/cryo-em-studies-of-drp1-reveal-cardiolipin-interactions-that-activate-the-helical-oligomer
#16
Christopher A Francy, Ryan W Clinton, Chris Fröhlich, Colleen Murphy, Jason A Mears
Dynamins are mechano-chemical GTPases involved in the remodeling of cellular membranes. In this study, we have investigated the mechanism of dynamin-related protein 1 (Drp1), a key mediator of mitochondrial fission. To date, it is unclear how Drp1 assembles on the mitochondrial outer membrane in response to different lipid signals to induce membrane fission. Here, we present cryo-EM structures of Drp1 helices on nanotubes with distinct lipid compositions to mimic membrane interactions with the fission machinery...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877602/-hi-mommy-parental-preferences-of-greetings-by-medical-staff
#17
Lisa Wilks-Gallo, Chaim Zev Aron, Catherine R Messina
The therapeutic alliance between pediatricians and parents begins at the initial encounter. The manner in which pediatricians greet family members influences this relationship. This study evaluated whether parents are addressed using generic titles and investigated perceptions of parents regarding how they are addressed by medical staff. Written surveys of 137 parents of pediatric inpatients collected opinions about greetings during medical encounters. Parents were asked if they have been addressed as Mom/Dad/Mommy/Daddy during past medical encounters and which generic titles they would prefer...
September 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28876192/do-we-think-children-need-a-mom-and-dad-understanding-how-gender-ideology-impact-attitudes-toward-same-gender-parent-family-rights
#18
Stephanie N Webb, Jill M Chonody, Phillip S Kavanagh
Research and opinion polls demonstrate that attitudes toward same-gender parent families have been improving in recent years among Western countries; however, the history of oppression toward, and misconceptions of, same-gender parent families continue to be demonstrated in Australian family rights policies. Common misconceptions include the belief that children need both male and female role models, and this could be influencing peoples' support for same-gender family rights and having a wider impact on legislation change...
September 6, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28872673/direction-of-dependence-in-measurement-error-models
#19
Wolfgang Wiedermann, Edgar C Merkle, Alexander von Eye
Methods to determine the direction of a regression line, that is, to determine the direction of dependence in reversible linear regression models (e.g., x→y vs. y→x), have experienced rapid development within the last decade. However, previous research largely rested on the assumption that the true predictor is measured without measurement error. The present paper extends the direction dependence principle to measurement error models. First, we discuss asymmetric representations of the reliability coefficient in terms of higher moments of variables and the attenuation of skewness and excess kurtosis due to measurement error...
September 5, 2017: British Journal of Mathematical and Statistical Psychology
https://www.readbyqxmd.com/read/28872664/middle-cerebral-artery-doppler-reference-centile-charts-for-the-prediction-of-fetal-anemia-in-a-population-from-india
#20
Manisha Kumar, Tarul Umrawal, Anuradha Singh
OBJECTIVE: To construct reference charts for the fetal middle cerebral artery (MCA) peak systolic velocity (PSV) and the corresponding cord blood hemoglobin values at 24-40 weeks of pregnancy for the identification of fetal anemia. METHODS: In a cross-sectional study, 300 women with a pregnancy duration of 24-40 weeks planned for delivery within 72 hours underwent a Doppler study of the MCA and cord blood hemoglobin estimation at delivery. Regression analysis was used to construct reference charts...
September 5, 2017: International Journal of Gynaecology and Obstetrics
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