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https://www.readbyqxmd.com/read/28936339/utility-of-vs38c-in-the-diagnostic-and-prognostic-assessment-of-osteosarcoma-and-other-bone-tumours-tumour-like-lesions
#1
E S Hookway, Z Orosz, Y Uchihara, A Grigoriadis, A B Hassan, U Oppermann, N A Athanasou
BACKGROUND: VS38c is a monoclonal antibody that recognises a rough endoplasmic reticulum (rER) intracellular antigen termed cytoskeleton-linking membrane protein 63. rER is typically found in viable tumour cells and is abundant in osteosarcoma cells. The aim of this study was to determine the diagnostic and prognostic utility of VS38c in the histological assessment of osteosarcoma and other bone tumours/tumour-like leisons. METHODS: Immunohistochemical staining with VS38c was carried out on formalin-fixed specimens of osteosarcoma (pre/post-chemotherapy) and a wide range of benign and malignant bone lesions...
2017: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/28921536/technical-note-a-simulation-study-on-the-feasibility-of-radiotherapy-dose-enhancement-with-calcium-tungstate-and-hafnium-oxide-nano-and-microparticles
#2
Nicholas J Sherck, You-Yeon Won
PURPOSE: To assess the radiotherapy dose enhancement (RDE) potential of calcium tungstate (CaWO4 ) and hafnium oxide (HfO2 ) nano- and microparticles (NPs). A Monte Carlo simulation study was conducted to gauge their respective RDE potentials relative to that of the broadly studied gold (Au) NP. The study was warranted due to the promising clinical and preclinical studies involving both CaWO4 and HfO2 NPs as RDE agents in the treatment of various types of cancers. The study provides a baseline RDE to which future experimental RDE trends can be compared to...
September 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/28913348/the-use-of-partial-least-square-regression-and-spectral-data-in-uv-visible-region-for-quantification-of-adulteration-in-indonesian-palm-civet-coffee
#3
Diding Suhandy, Meinilwita Yulia
Asian palm civet coffee or kopi luwak (Indonesian words for coffee and palm civet) is well known as the world's priciest and rarest coffee. To protect the authenticity of luwak coffee and protect consumer from luwak coffee adulteration, it is very important to develop a robust and simple method for determining the adulteration of luwak coffee. In this research, the use of UV-Visible spectra combined with PLSR was evaluated to establish rapid and simple methods for quantification of adulteration in luwak-arabica coffee blend...
2017: International journal of food science
https://www.readbyqxmd.com/read/28912726/cardiovascular-and-muscular-consequences-of-work-matched-interval-type-of-concentric-and-eccentric-pedaling-exercise-on-a-soft-robot
#4
Martin Flück, Rebekka Bosshard, Max Lungarella
Eccentric types of endurance exercise are an acknowledged alternative to conventional concentric types of exercise rehabilitation for the cardiac patient, because they reduce cardiorespiratory strain due to a lower metabolic cost of producing an equivalent mechanical output. The former contention has not been tested in a power- and work-matched situation of interval-type exercise under identical conditions because concentric and eccentric types of exercise pose specific demands on the exercise machinery, which are not fulfilled in current practice...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28892419/the-effect-of-a-backpack-hip-strap-on-energy-expenditure-while-walking
#5
Jamie Pigman, William Sullivan, Steven Leigh, Peter A Hosick
Objective To examine the effect of backpack hip strap use on walking energy expenditure while carrying a loaded backpack. Background Previous studies have demonstrated that energy cost increases as the mass of the load carried increases. However, few investigations have focused on backpack carriage design. Methods Fifteen young, healthy, male subjects walked at a self-selected pace for 10 minutes in two backpack loading conditions: with a hip strap (strapped) and without a hip strap (nonstrapped). Oxygen consumption (VO2), rating of perceived exertion (RPE), respiratory exchange ratio (RER), and heart rate (HR) were monitored throughout each 10-minute trial...
September 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28874630/decellularized-human-dermal-matrix-produced-by-a-skin-bank-a-new-treatment-for-abdominal-wall-defects
#6
Martina Ghetti, Elena Bondioli, Valeria Purpura, Giovanna Cenacchi, Paolo Ruscelli, Davide Melandri
BACKGROUND: Interest is increasing for human decellularized scaffolds for their ability to favor healing and cell infiltration after transplantation, in the treatment of abdominal wall defects. The purpose of the present study is to show the clinical results obtained after the application of human decellularized dermal matrix (HDM) produced by RER Skin Bank, on patients suffering from different abdominal wall defects. METHODS: Between 2012 and 2014, 64 patients, average age 64 years, received HDM, to replace and cover the damage area during abdominal wall surgery...
July 25, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28860186/heat-shock-protein-47-and-65-kda-fk506-binding-protein-weakly-but-synergistically-interact-during-collagen-folding-in-the-endoplasmic-reticulum
#7
Yoshihiro Ishikawa, Paul Holden, Hans Peter Bachinger
Collagen is the most abundant protein in the extracellular matrix in humans and is critical to the integrity and function of many musculoskeletal tissues. A molecular ensemble comprising more than twenty molecules is involved in collagen biosynthesis in the rough endoplasmic reticulum (rER). Two proteins, Heat shock protein 47 (Hsp47/SERPINH1) and 65 KDa FK506 binding protein (FKBP65/FKBP10) have been shown to play important roles in this ensemble. In humans, autosomal recessive mutations in both genes cause similar Osteogenesis Imperfecta (OI) phenotypes...
August 31, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28853156/characterization-and-predicting-of-carbohydrate-content-in-zucchini-fruit-using-near-infrared-spectroscopy
#8
Teresa Pomares-Viciana, Damián Martínez-Valdivieso, Rafael Font, Pedro Gómez, Mercedes Del Rio-Celestino
BACKGROUND: Zucchini fruit plays an important part in healthy nutrition due to its high content of carbohydrates. Recent studies have demonstrated the feasibility of Vis/NIRS to predict quality profile. However, this procedure has not been applied to determinate carbohydrates. RESULTS: VIS-NIR and wet chemical methods were used to determinate individual sugars and starch in zucchini fruits. By applying a principal component analysis (PCA) with NIR spectral data a differentiation between the less sweet vs...
August 29, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28846671/effects-of-postnatal-overfeeding-and-fish-oil-diet-on-energy-expenditure-in-rats
#9
Yanyan Dai, Nan Zhou, Fan Yang, Shanshan Zhou, Lijun Sha, Jianping Wang, Xiaonan Li
BACKGROUD: Early life nutrition may have a role in the regulation of metabolism in adulthood. The present study aimed to evaluate the effects of postnatal overfeeding and a postweaning fish oil diet on energy expenditure. METHODS: On postnatal day 3, rat litters were adjusted to a litter size of three (small litters, SLs) or ten (normal litters, NLs). After weaning, SLs were fed the standard diet or a fish oil diet enriched with polyunsaturated fatty acids (SL-FOs) for 10 weeks...
August 28, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28841254/functional-capacity-in-a-rat-model-of-heart-failure-impact-of-myocardial-infarction-size
#10
Vítor Scotta Hentschke, Lucas Capalonga, Douglas Dalcin Rossato, Júlia Luíza Perini, Jadson Pereira Alves, Edson Quagliotto, Giuseppe Potrick Stefani, Marlus Karsten, Mauro Pontes, Pedro Dal Lago
Oxygen uptake (VO2 ) and exercise tolerance in rats classified by myocardial infarction (MI) size are underexplored. The aim of this study was to evaluate VO2 /carbon dioxide production (VCO2 ) and exercise tolerance in rats that have undergone MI. Fourteen weeks after MI or sham surgery, rats underwent an integrated approach to left ventricular function and VO2 /VCO2 , exercise tolerance and skeletal muscle weight evaluation. Based on MI size determination, rats were assigned to sham operated controls (Sham, n = 12), small myocardial infarction (SMI, n = 8), and large myocardial infarction (LMI, n = 5) groups...
August 25, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28830330/ultrastructural-alterations-in-thyrocytes-of-zebrafish-danio-rerio-after-exposure-to-propylthiouracil-and-perchlorate
#11
Florian Schmidt, Raoul Wolf, Lisa Baumann, Thomas Braunbeck
Histopathology is a widely used approach to evaluate effects of endocrine-active chemicals in the thyroid. However, effects at an ultrastructural level have hardly been examined in fish thyroids. In the present study, zebrafish was exposed to sublethal concentrations of propylthiouracil (PTU; 0-50 mg/L) and perchlorate (PER; 0-5,000 µg/L) for 5 weeks in a modified early life-stage test. None of the treatments caused significant mortality (no observed effect concentrations for survival ≥50 mg/L [PTU] and ≥5,000 µg/L [PER])...
July 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28826698/reliability-of-resting-metabolic-rate-measurements-in-young-adults-impact-of-methods-for-data-analysis
#12
Guillermo Sanchez-Delgado, Juan M A Alcantara, Lourdes Ortiz-Alvarez, Huiwen Xu, Borja Martinez-Tellez, Idoia Labayen, Jonatan R Ruiz
BACKGROUND & AIMS: A high inter-day reliability is a key factor to analyze the magnitude of change in resting metabolic rate (RMR) after an intervention, and the impact of using different methods for data analysis is not known. The aims of this study were: i) to analyze the impact of methods for data analysis on RMR and respiratory exchange ratio (RER) estimation; ii) to analyze the impact of methods for data analysis on inter-day RMR and RER reliability; iii) to compare inter-day RMR and RER reliability across methods for data analysis in participants who achieved steady state (SS) vs...
August 5, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28825967/dietary-acid-load-and-renal-function-have-varying-effects-on-blood-acid-base-status-and-exercise-performance-across-age-and-gender
#13
Enni-Maria Hietavala, Jeffrey R Stout, Lynda A Frassetto, Risto Puurtinen, Hannu Pitkänen, Harri Selänne, Harri Suominen, Antti A Mero
PURPOSE: Diet composition influences acid-base status of the body. This may become more relevant as renal functional capacity declines with aging. We examined the effects of low (LD) versus high dietary acid load (HD) on blood acid-base status and exercise performance. METHODS: Participants included 22 adolescents (AD), 33 young adults (YA) and 33 elderly (EL), who followed a 7-day LD and HD in a randomized order. At the end of both diet periods the subjects performed a cycle ergometer test (3x10 min at 35%, 55%, 75%, and (except EL) until exhaustion at 100% of VO2max)...
August 21, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28774754/altitudinal-variation-in-metabolic-parameters-of-a-small-afrotropical-bird
#14
Lindy J Thompson, Colleen T Downs
Of the numerous factors affecting avian metabolic rate, altitude is one of the least studied. We used mass-flow respirometry to measure resting metabolic rate (RMR), evaporative water loss (EWL) and respiratory exchange ratio (RER) in two populations of a small (10-12g) Afrotropical bird, the Cape White-eye (Zosterops virens), in summer and in winter. In total, 51 freshly wild-caught adult Cape White-eyes were measured overnight. Altitude was included as a source of variation in the best approximating models for body mass, whole-animal RMR, RER, whole-animal standard EWL and whole-animal basal EWL...
July 31, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28763620/acute-effects-of-exercise-intensity-on-subsequent-substrate-utilisation-appetite-and-energy-balance-in-men-and-women
#15
Ghalia Shamlan, Paul Bech, M Denise Robertson, Adam L Collins
Exercise is capable of influencing the regulation of energy balance by acutely modulating appetite and energy intake coupled to effects on substrate utilization. Yet, few studies have examined acute effects of exercise intensity on aspects of both energy intake and energy metabolism, independently of energy cost of exercise. Furthermore, little is known as to the gender differences of these effect. One hour after a standardised breakfast, 40 (19 female), healthy participants (BMI 23.6±3.6 kg.m-2, VO2peak 34...
August 1, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28761700/a-novel-treadmill-protocol-for-exercise-testing-in-children-the-british-columbia-children-s-hospital-protocol
#16
D Kathryn Duff, Astrid M De Souza, Derek G Human, James E Potts, Kevin C Harris
BACKGROUND: Exercise testing in children is widely recommended for a number of clinical and prescriptive reasons. Many institutions continue to use the Bruce protocol for treadmill testing; however, with its incremental changes in speed and grade, it has challenges for practical application in children. We have developed a novel institutional protocol (British Columbia Children's Hospital (BCCH)), which may have better utility in paediatric populations. AIM: To determine if our institutional protocol yields similar peak responses in minute ventilation (VE), oxygen consumption (VO2), carbon dioxide production (VCO2), respiratory exchange ratio (RER), metabolic equivalents (METS) and heart rate (HR) when compared with the traditional Bruce protocol...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28758565/lysosomal-responses-to-different-gold-forms-nanoparticles-aqueous-bulk-in-mussel-digestive-cells-a-trade-off-between-the-toxicity-of-the-capping-agent-and-form-size-and-exposure-concentration
#17
A Jimeno-Romero, U Izagirre, D Gilliland, A Warley, M P Cajaraville, I Marigómez, M Soto
Gold nanoparticles (NPs) are increasingly used in technological materials and consumer products and may have toxicological characteristics distinct from bulk and aqueous gold. The aim of this work was to understand the effects of Au NPs especially, how the form, the size and the coating influence bioaccumulation/biodistribution and toxicity of NPs in mussels, Mytilus galloprovincialis. Mussels were exposed for 3 d to concentrations of Au (0.75, 75 and 750 μg Au/l) supplied as Au-Cit NPs (5 and 40 nm; Au5-Cit and Au40-Cit), bulk and aqueous Au (HAu(III)Cl4), and to the capping agent (Na-citrate) in doses used in the formulation of NPs (0...
June 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28750585/nutritional-ketone-salts-increase-fat-oxidation-but-impair-high-intensity-exercise-performance-in-healthy-adult-males
#18
Trevor O'Malley, Etienne Myette-Cote, Cody Durrer, Jonathan P Little
This study investigated the impact of raising plasma beta-hydroxybutyrate (β-OHB) through ingestion of ketone salts on substrate oxidation and performance during cycling exercise. Ten healthy adult males (age, 23 ± 3 years; body mass index, 25 ± 3 kg/m(2), peak oxygen uptake, 45 ± 10 mL/(kg·min)(-1)) were recruited to complete 2 experimental trials. Before enrollment in the experimental conditions, baseline anthropometrics and cardiorespiratory fitness (peak oxygen uptake) were assessed and familiarization to the study protocol was provided...
July 27, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28750221/cell-damage-and-apoptosis-in-the-hepatopancreas-of-eriocheir-sinensis-induced-by-cadmium
#19
Yong Lin, Jia-Jia Huang, Hans-Uwe Dahms, Jing-Jing Zhen, Xue-Ping Ying
Cadmium (Cd) is one of the most common pollutants in the environment and it is known to cause a range of tissue damages and apoptosis in invertebrates. In this study, we investigated the effect of Cd on the hepatopancreas of the crab Eriocheir sinensis, a commercially and ecologically important species of crustacean. The crabs were first exposed to water containing different concentrations of Cd(2+) (0, 0.63, 1.26, 2.52, 5.04 and 10.07mg/L) for 6days. Typical morphological characteristics and physiological changes of apoptosis were then observed using various methods, including AO/EB double fluorescence staining, transmission electron microscopy and DNA fragmentation analysis...
September 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28730728/beneficial-long-term-antidiabetic-actions-of-n-and-c-terminally-modified-analogues-of-apelin-13-in-diet-induced-obese-diabetic-mice
#20
Vadivel Parthsarathy, Christopher Hogg, Peter R Flatt, Finbarr P M O'Harte
AIMS: To investigate the chronic effects of twice-daily administration of stable apelin analogues, apelin-13 amide and pyroglutamyl (pGlu) apelin-13 amide, on metabolic variables in glucose-intolerant and insulin-resistant diet-induced obese mice fed a high-fat diet for 150 days. METHODS: Groups of mice received twice-daily (9 am and 5 pm) injections of saline vehicle, apelin-13 amide, (pGlu)apelin-13 amide or exendin-4(1-39) for 28 days (all at 25 nmol/kg)...
July 20, 2017: Diabetes, Obesity & Metabolism
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