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https://www.readbyqxmd.com/read/27916643/homeostatic-effects-of-exercise-and-sleep-on-metabolic-processes-in-mice-with-an-overexpressed-skeletal-muscle-clock
#1
Allison J Brager, Lydia Heemstra, Raman Bhambra, J Christopher Ehlen, Karyn A Esser, Ketema N Paul, Colleen M Novak
Brain and muscle-ARNT-like factor (Bmal1/BMAL1) is an essential transcriptional/translational factor of circadian clocks. Loss of function of Bmal1/BMAL1 is highly disruptive to physiological and behavioral processes. In light of these previous findings, we examined if transgenic overexpression of Bmal1/BMAL1 in skeletal muscle could alter metabolic processes. First, we characterized in vivo and ex vivo metabolic phenotypes of muscle overexpressed mice (male and female) compared to wild-type littermates (WT)...
December 1, 2016: Biochimie
https://www.readbyqxmd.com/read/27914920/can-lowering-the-guidance-force-of-robot-assisted-gait-training-induce-a-sufficient-metabolic-demand-in-subacute-dependent-ambulatory-stroke-patients
#2
So Young Lee, Eun Young Han, Bo Ryun Kim, Min Ho Chun, Yong Ki Lee
OBJECTIVE: To assess the effects of guidance force (GF) and gait speed (GS) on cardiorespiratory responses and energy cost in subacute dependent ambulatory stroke patients. DESIGN: Cross sectional study. SETTING: University rehabilitation hospital. PARTICIPANTS: Ten subacute stroke patients (mean age: 64.50±19.20), who were dependent ambulators (functional ambulation category [FAC] ≤2). INTERVENTIONS: Patients participated in cardiorespiratory tests during robot-assisted gait training...
November 30, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27871814/dr-alois-huger-laying-the-foundations-for-an-integrated-insect-pathology
#3
Trevor A Jackson
Dr. rer. nat. Alois M. Huger had a long and distinguished career at the Institut für biologische Schädlingsbekämpfung (Institute for Biological Pest Control) Darmstadt, Germany, where he became one of the world's leading insect pathologists. He applied his experience and understanding of insect tissues and specialist skills in microscopy to diagnosis and elucidation of the pathology of insect diseases. During his career he discovered the Oryctes nudivirus and Bacillus thuringiensis subsp. tenebrionis, and was a member of teams unravelling amber disease in scarab beetles and the role of bacteria in parthenogenesis of parasitoids...
November 18, 2016: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/27869096/predictive-factor-analysis-of-response-adapted-radiation-therapy-for-chemotherapy-sensitive-pediatric-hodgkin-lymphoma-analysis-of-the-children-s-oncology-group-ahod-0031-trial
#4
Anne-Marie Charpentier, Debra L Friedman, Suzanne Wolden, Cindy Schwartz, Bethany Gill, Jenna Sykes, Alisha Albert-Green, Kara M Kelly, Louis S Constine, David C Hodgson
PURPOSE: To evaluate whether clinical risk factors could further distinguish children with intermediate-risk Hodgkin lymphoma (HL) with rapid early and complete anatomic response (RER/CR) who benefit significantly from involved-field RT (IFRT) from those who do not, and thereby aid refinement of treatment selection. METHODS AND MATERIALS: Children with intermediate-risk HL treated on the Children's Oncology Group AHOD 0031 trial who achieved RER/CR with 4 cycles of chemotherapy, and who were randomized to 21-Gy IFRT or no additional therapy (n=716) were the subject of this study...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27863384/a-novel-highly-potent-trivalent-tgf-%C3%AE-receptor-trap-inhibits-early-stage-tumorigenesis-and-tumor-cell-invasion-in-murine-pten-deficient-prostate-glands
#5
Tai Qin, Lindsey Barron, Lu Xia, Haojie Huang, Maria M Villarreal, John Zwaagstra, Cathy Collins, Junhua Yang, Christian Zwieb, Ravindra Kodali, Cynthia S Hinck, Sun Kyung Kim, Robert L Reddick, Chang Shu, Maureen D O'Connor-McCourt, Andrew P Hinck, Lu-Zhe Sun
The effects of transforming growth factor beta (TGF-β) signaling on prostate tumorigenesis has been shown to be strongly dependent on the stage of development, with TGF-β functioning as a tumor suppressor in early stages of disease and as a promoter in later stages. To study in further detail the paradoxical tumor-suppressive and tumor-promoting roles of the TGF-β pathway, we investigated the effect of systemic treatment with a TGF-β inhibitor on early stages of prostate tumorigenesis. To ensure effective inhibition, we developed and employed a novel trivalent TGF-β receptor trap, RER, comprised of domains derived from the TGF-β type II and type III receptors...
November 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27851893/caffeine-influences-cadence-at-lower-but-not-higher-intensity-rpe-regulated-cycling
#6
J Matt Green, Alyssa Olenick, Caroline Eastep, Lee Winchester
: Caffeine blunts RPE estimations but effects on selected cycling cadence are unclear. PURPOSE: This study examined influence of caffeine on cycling cadence with intensities prescribed at RPE 4 and 7 (OMNI Scale). METHODS: College-aged (20.5±2.0y) male and female volunteers (n=15) (VO2 peak=40.3±4.0,) completed a maximal cycling test followed by trials where they adjusted cadence (CAD) (clamped resistances) to produce overall feelings equivalent to RPE 4 (RPE4) and RPE 7 (RPE7) (10min each) following caffeine (CAF) (6mg·kg(-1)·min(-1)) and placebo (PLA) (counterbalanced) ingestion...
November 13, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27849117/metabolic-responses-to-a-loaded-movement-training-workout
#7
Derek N Vandenbrink, Nicholas J Petrella, Eric V Neufeld, Brett A Dolezal, Daniel P Maclennan
BACKGROUND: Few studies have investigated the metabolic demands of functional exercise. We determined the oxygen cost, heart rate (HR) response, and energy expenditure (EE) both during and immediately following a loaded movement training (LMT) workout. METHODS: Ten participants (5 male, age = 23.5 ± 3.7 years, VO2peak = 53.3 ± 6.4 ml∙kg-1∙min- 1) completed baseline resting metabolic rate testing, a maximal oxygen uptake (VO2) test, and a familiarization trial...
November 16, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27824689/eccentric-cycling-a-promising-modality-for-patients-with-chronic-heart-failure
#8
Lauren C Chasland, Daniel J Green, Andrew J Maiorana, Kazunori Nosaka, Andrew Haynes, Lawrence Dembo, Louise H Naylor
INTRODUCTION: Chronic heart failure (CHF) is characterized by dyspnea and poor exercise tolerance, which decreases aerobic capacity (V˙O2peak), a measure strongly correlated with quality of life and mortality. In healthy populations, eccentric (ECC) cycling can be performed at a lower oxygen demand for matched workload, compared to concentric (CON) cycling, but few studies have previously investigated ECC cycling in CHF. We hypothesized that, when matched for external workload (Watts), an ECC cycling bout would be performed at a lower cardiorespiratory load (V˙O2) than CON in patients with CHF...
November 7, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27810701/breast-cancer-diagnosis-and-mortality-by-tumor-stage-and-migration-background-in-a-nationwide-cohort-study-in-sweden
#9
Gholamreza Abdoli, Matteo Bottai, Kerstin Sandelin, Tahereh Moradi
INTRODUCTION: Survival in breast cancer patients has steadily increased over the years, but with considerable disparities between individuals with different migration background and social position. We explored differences in diagnosis and all-cause mortality in breast cancer patients by stage of disease at the time of diagnosis and by country of birth, while considering the effect of comorbidity, regional and socio-demographic factors. METHODS: We used Swedish national registers to follow a cohort of 35,268 patients (4232 foreign-born) with breast cancer between 2004 and 2009 in Sweden...
October 31, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27806012/acute-effects-of-plyometric-and-resistance-training-on-running-economy-in-trained-runners
#10
Richard T Marcello, Beau Kjerulf Greer, Anna E Greer
Results regarding the acute effects of plyometric and resistance training (PRT) on running economy (RE) are conflicting. Eight male collegiate distance runners (21 ± 1 years, 62.5 ± 7.8 ml/kg/min V[Combining Dot Above]O2 peak) completed V[Combining Dot Above]O2 peak and 1 repetition maximum (1RM) testing. Seven days later, subjects completed a 12 minute RE test at 60% and 80% V[Combining Dot Above]O2 peak, followed by a PRT protocol or a rested condition of equal duration (CON). The PRT protocol consisted of 3 sets of 5 repetitions at 85% 1RM for barbell squats, Romanian deadlifts, and barbell lunges; the same volume was utilized for resisted lateral lunges, box jumps, and depth jumps...
October 28, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27769625/effect-of-genetically-modified-corn-on-the-jejunal-mucosa-of-adult-male-albino-rat
#11
Marwa A A Ibrahim, Ebtsam F Okasha
Genetically modified (GM) plants expressing insecticidal traits offer a new strategy for crop protection. GM-corn contains Bacillus thuringiensis (Bt) genes producing delta endotoxins in the whole plant. Diet can influence the characteristics of the gastrointestinal tract altering its function and structure. The aim of this study was to evaluate the effect of GM-corn on the histological structure of jejunal mucosa of adult male albino rat using different histological, immunohistochemical and morphometrical methods...
October 18, 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/27766133/the-effect-of-a-moderately-low-and-high-carbohydrate-intake-on-crossfit-performance
#12
Kurt A Escobar, Jacobo Morales, Trisha A Vandusseldorp
CrossFit is a metabolically demanding strength and conditioning method which performance may benefit from a carbohydrate (CHO)-rich diet. This study investigated the effect of three consecutive days of high CHO intake on CrossFit performance and corresponding metabolically -related variables in strength trained individuals. Eighteen subjects with a CHO intake of <6 g/kg/day were randomly assigned into a CHO (n = 9) or control (C) group (n =9) and underwent a 9-day training protocol. During days 1, 5, and 9, performance was measured as repetitions completed during a 12 minute CrossFit workout...
2016: International Journal of Exercise Science
https://www.readbyqxmd.com/read/27763583/altered-gas-exchange-at-peak-exercise-in-obese-adolescents-implications-for-verification-of-effort-during-cardiopulmonary-exercise-testing
#13
Nastasia Marinus, Liene Bervoets, Guy Massa, Kenneth Verboven, An Stevens, Tim Takken, Dominique Hansen
BACKGROUND: Cardiopulmonary exercise testing is advised ahead of exercise intervention in obese adolescents to assess medical safety of exercise and physical fitness. Optimal validity and reliability of test results are required to identify maximal exercise effort. As fat oxidation during exercise is disturbed in obese individuals, it remains an unresolved methodological issue whether the respiratory gas exchange ratio (RER) is a valid marker for maximal effort during exercise testing in this population...
October 20, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27749259/comparison-of-the-effects-of-difenacoum-and-brodifacoum-on-the-ultrastructure-of-rat-liver-cells
#14
Nursel Gül, Nuri Yiğit, Fulya Saygılı, Ebru Demirel, Ceren Geniş
We used transmission electron microscopy to examine the cytotoxic effects of the second-generation anticoagulant rodenticides difenacoum and brodifacoum on rat liver. A single dose of difenacoum or brodifacoum was administered to rats by gastric gavage and liver samples were taken after 24 h, four days or seven days. In the livers of rats treated with difenacoum for 24 h, hepatocytes typically showed increased numbers of lysosomes, as well as enlargement of both the perinuclear space and the cisternae of the rough endoplasmic reticulum (RER), while sinusoids were irregularly shaped and contained Kupffer cells...
September 1, 2016: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/27747847/the-acute-effect-of-exercise-modality-and-nutrition-manipulations-on-post-exercise-resting-energy-expenditure-and-respiratory-exchange-ratio-in-women-a-randomized-trial
#15
Hailee L Wingfield, Abbie E Smith-Ryan, Malia N Melvin, Erica J Roelofs, Eric T Trexler, Anthony C Hackney, Mark A Weaver, Eric D Ryan
BACKGROUND: The purpose of this study was to examine the effect of exercise modality and pre-exercise carbohydrate (CHO) or protein (PRO) ingestion on post-exercise resting energy expenditure (REE) and respiratory exchange ratio (RER) in women. METHODS: Twenty recreationally active women (mean ± SD; age 24.6 ± 3.9 years; height 164.4 ± 6.6 cm; weight 62.7 ± 6.6 kg) participated in this randomized, crossover, double-blind study. Each participant completed six exercise sessions, consisting of three exercise modalities: aerobic endurance exercise (AEE), high-intensity interval running (HIIT), and high-intensity resistance training (HIRT); and two acute nutritional interventions: CHO and PRO...
December 2015: Sports Medicine—Open
https://www.readbyqxmd.com/read/27737609/metabolic-characterization-of-overweight-and-obese-adults
#16
Katie R Hirsch, Abbie E Smith-Ryan, Malia N M Blue, Meredith G Mock, Eric T Trexler, Kristin S Ondrak
OBJECTIVES: Traditional evaluations of metabolic health may overlook underlying dysfunction in individuals who show no signs of insulin resistance or dyslipidemia. The purpose of this study was to characterize metabolic health in overweight and obese adults using traditional and non-traditional cardiometabolic variables. A secondary purpose was to evaluate differences between overweight/obese and male/female cohorts, respectively. METHODS: Forty-nine overweight and obese adults (Mean ± SD; Age=35...
October 13, 2016: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/27727198/cardiorespiratory-and-metabolic-responses-after-exercise-induced-muscle-damage-the-influence-of-lowered-glycogen
#17
James P Gavin, Stephen D Myers, Mark E Willems
BACKGROUND: We examined the effect of early-onset of muscle damage and low muscle glycogen on cardiorespiratory and metabolic responses to low-intensity exercise. METHODS: Twelve men cycled for 10 min at 50% maximal oxygen uptake before, and 12 h after a morning downhill run (five, 8 min bouts at -12% gradient, with 2 min rests) under normal (NORM) and lowered glycogen (LOW) conditions, following a cross-over design with conditions separated by six weeks. Cardiorespiratory responses were recorded, with oxidation measures derived from stoichiometry equations...
October 11, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27679847/intracellular-mechanisms-of-molecular-recognition-and-sorting-for-transport-of-large-extracellular-matrix-molecules
#18
Yoshihiro Ishikawa, Shinya Ito, Kazuhiro Nagata, Lynn Y Sakai, Hans Peter Bächinger
Extracellular matrix (ECM) proteins are biosynthesized in the rough endoplasmic reticulum (rER) and transported via the Golgi apparatus to the extracellular space. The coat protein complex II (COPII) transport vesicles are approximately 60-90 nm in diameter. However, several ECM molecules are much larger, up to several hundreds of nanometers. Therefore, special COPII vesicles are required to coat and transport these molecules. Transmembrane Protein Transport and Golgi Organization 1 (TANGO1) facilitates loading of collagens into special vesicles...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27618857/the-long-road-to-steady-state-in-gas-exchange-metabolic-and-ventilatory-responses-to-hypercapnia-and-hypoxia-in-cuvier-s-dwarf-caiman
#19
Christian Lind Malte, Hans Malte, Tobias Wang
Animals with intermittent lung ventilation and those exposed to hypoxia and hypercapnia will experience fluctuations in the bodily O2 and CO2 stores, but the magnitude and duration of these changes are not well understood amongst ectotherms. Using the changes in the respiratory exchange ratio (RER; CO2 excretion divided by O2 uptake) as a proxy for changes in bodily gas stores, we quantified time constants in response to hypoxia and hypercapnia in Cuvier's dwarf caiman. We confirm distinct and prolonged changes in RER during and after exposure to hypoxia or hypercapnia...
December 1, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27614882/markers-of-biological-stress-in-response-to-a-single-session-of-high-intensity-interval-training-and-high-volume-training-in-young-athletes
#20
Yvonne Kilian, Florian Engel, Patrick Wahl, Silvia Achtzehn, Billy Sperlich, Joachim Mester
PURPOSE: The aim of the present study was to compare the effects of high-intensity interval training (HIIT) vs high-volume training (HVT) on salivary stress markers [cortisol (sC), testosterone (sT), alpha-amylase (sAA)], metabolic and cardiorespiratory response in young athletes. METHODS: Twelve young male cyclists (14 ± 1 years; 57.9 ± 9.4 mL min(-1) kg(-1) peak oxygen uptake) performed one session of HIIT (4 × 4 min intervals at 90-95 % peak power output separated by 3 min of active rest) and one session of HVT (90 min constant load at 60 % peak power output)...
September 10, 2016: European Journal of Applied Physiology
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