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https://www.readbyqxmd.com/read/28106120/altered-glucose-and-lipid-homeostasis-in-liver-and-adipose-tissue-pre-dispose-inducible-nos-knockout-mice-to-insulin-resistance
#1
Babu Nageswararao Kanuri, Jitendra S Kanshana, Sanjay C Rebello, Priya Pathak, Anand P Gupta, Jiaur R Gayen, Kumaravelu Jagavelu, Madhu Dikshit
On the basis of diet induced obesity and KO mice models, nitric oxide is implied to play an important role in the initiation of dyslipidemia induced insulin resistance. However, outcomes using iNOS KO mice have so far remained inconclusive. The present study aimed to assess IR in iNOS KO mice after 5 weeks of LFD feeding by monitoring body composition, energy homeostasis, insulin sensitivity/signaling, nitrite content and gene expressions changes in the tissues. We found that body weight and fat content in KO mice were significantly higher while the respiratory exchange ratio (RER), volume of carbon dioxide (VCO2), and heat production were lower as compared to WT mice...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28090793/development-and-validation-of-a-predictor-of-insufficient-enhancement-during-the-hepatobiliary-phase-of-gd-eob-dtpa-enhanced-magnetic-resonance-imaging
#2
Enming Cui, Wansheng Long, Liangping Luo, Maoqing Hu, Liebin Huang, Xiangmeng Chen
Background Insufficient enhancement of liver parenchyma negatively affects diagnostic accuracy of Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI). Currently, there is no reliable method for predicting insufficient enhancement during the hepatobiliary phase (HBP) in Gd-EOB-DTPA-enhanced MRI. Purpose To develop a predictor for insufficient enhancement of liver parenchyma during HBP in Gd-EOB-DTPA-enhanced MRI. Material and Methods In order to formulate a HBP enhancement test (HBP-ET), clinical factors associated with relative enhancement ratio (RER) of liver parenchyma were retrospectively determined from the datasets of 156 patients (Development group) who underwent Gd-EOB-DTPA-enhanced MRI between November 2012 and May 2015...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28090142/the-midpoint-between-ventilatory-thresholds-approaches-maximal-lactate-steady-state-intensity-in-amateur-cyclists
#3
A B Peinado, Dm Pessôa Filho, V Díaz, P J Benito, M Álvarez-Sánchez, A G Zapico, F J Calderón
The aim was to determine whether the midpoint between ventilatory thresholds (MPVT) corresponds to maximal lactate steady state (MLSS). Twelve amateur cyclists (21.0 ± 2.6 years old; 72.2 ± 9.0 kg; 179.8 ± 7.5 cm) performed an incremental test (25 W·min(-1)) until exhaustion and several constant load tests of 30 minutes to determine MLSS, on different occasions. Using MLSS determination as the reference method, the agreement with five other parameters (MPVT; first and second ventilatory thresholds: VT1 and VT2; respiratory exchange ratio equal to 1: RER = 1...
December 2016: Biology of Sport
https://www.readbyqxmd.com/read/28079107/phenotyping-for-the-dynamics-of-field-wheat-root-system-architecture
#4
Xinxin Chen, Qishuo Ding, Zbigniew Błaszkiewicz, Jiuai Sun, Qian Sun, Ruiyin He, Yinian Li
We investigated a method to quantify field-state wheat RSA in a phenotyping way, depicting the 3D topology of wheat RSA in 14d periods. The phenotyping procedure, proposed for understanding the spatio-temporal variations of root-soil interaction and the RSA dynamics in the field, is realized with a set of indices of mm scale precision, illustrating the gradients of both wheat root angle and elongation rate along soil depth, as well as the foraging potential along the side directions. The 70d was identified as the shifting point distinguishing the linear root length elongation from power-law development...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28040618/oxidative-damage-ultrastructural-alterations-and-gene-expressions-of-hemocytes-in-the-freshwater-crab-sinopotamon-henanense-exposed-to-cadmium
#5
Yanying Zhou, Weixin Jing, Hans-Uwe Dahms, Jiang-Shiou Hwang, Lan Wang
Toxicity of Cd was tested with the hemocytes of the freshwater crab, Sinopotamon henanense, which were exposed to concentrations of 0, 0.725, 1.450, and 2.900mgL(-1) Cd for 7, 14 and 21 d. We investigated the effects of Cd on the total antioxidant capacity (TAC), and oxidative damage of biomarkers, such as malondialdehyde (MDA), protein carbonyl derivates (PCO), and DNA-protein crosslink (DPC). Transmission electron microscopy (TEM) was applied to assess ultrastructural changes of hemocytes. The mRNA expression levels of prophenoloxidase (proPO), lysozyme (LSZ), metallothionein (MT), and the activity of phenoloxidase (PO) were also determined...
December 29, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28028037/muscle-interleukin-6-and-fasting-induced-pdh-regulation-in-mouse-skeletal-muscle
#6
Anders Gudiksen, Lærke Bertholdt, Mikkel Birkkjær Vingborg, Henriette Watson Hansen, Stine Ringholm Ringholm, Henriette Pilegaard
Fasting prompts a metabolic shift in substrate utilization from carbohydrate to predominant fat oxidation in skeletal muscle and pyruvate dehydrogenase (PDH) is seen as a controlling link between the competitive oxidation of carbohydrate and fat during metabolic challenges like fasting. Interleukin (IL)-6 has been proposed to be released from muscle with concomitant effects on both glucose and fat utilization. The aim was to test the hypothesis that IL-6 has a regulatory impact on fasting-induced suppression of skeletal muscle PDH...
December 27, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28004426/inhibition-of-anaphase-promoting-complex-by-silence-apc-ccdh1to-enhance-radiosensitivity-of-nasopharyngeal-carcinoma-cells
#7
Chunmiao Wang, Zhengying Su, Huaxin Hou, Danrong Li, Zhiyu Pan, Wei Tian, Chunyan Mo
The aim of this study was to investigate the possibility of APC/C(Cdh1) as a potential therapeutic target in the radiosensitivity of nasopharyngeal carcinoma(NPC) cell CNE-1, and explain the role of APC subunits after silence of Cdh1 combined with radiotherapy. Transfection with Cdh1 shRNA significantly increased the radiosensitivity of CNE-1 cells and the radiation enhancement ratio (RER) of sh-Cdh1 cells was 1.76. Knockdown of Cdh1 in CNE-1 cells increased irradiation induced apoptosis and G2/M phase cell cycle arrest...
December 22, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27996337/steady-state-energy-balance-in-animal-models-of-obesity-and-weight-loss
#8
Magnus Kringstad Olsen, Helene Johannessen, Nikki Cassie, Perry Barrett, Koji Takeuchi, Bård Kulseng, Duan Chen, Chun-Mei Zhao
OBJECTIVE: We wanted to exam the steady-state energy balance by using high-fat diet-induced obese (DIO) rats and mice as models for positive energy balance, and gastric bypassed (GB) rats and gene knockout of muscarinic acetylcholine M3 receptor (M3KO) mice as models for negative energy balance. METHODS: One hundred and thirty-two rats and mice were used. Energy balance was measured by a comprehensive laboratory animal monitoring system. Gene expression was analysed by in situ hybridisation in M3KO mice...
December 20, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27968756/palatability-and-clinical-effects-of-an-oral-recuperation-fluid-during-the-recovery-of-dogs-with-suspected-parvoviral-enteritis
#9
REVIEW
Reut Tenne, Lauren A Sullivan, Elena T Contreras, Francisco Olea-Popelka, David C Twedt, Jeffrey Fankhauser, Logan Mastrianna, Michael R Lappin
Dogs infected with canine parvovirus (CPV) can develop severe enteritis that requires supportive care until voluntary food and water consumption return. An oral recuperation fluid (ORF) may assist in the overall recovery from CPV. The hypotheses of the study were that dogs with naturally infected CPV would prefer the ORF to water and that dogs consuming the ORF would have a more rapid return to voluntary appetite and improved caloric intake during the initial recovery period compared with dogs consuming water...
June 2016: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/27928213/proposal-for-a-specific-aerobic-test-for-football-players-the-footeval
#10
Christophe Manouvrier, Johan Cassirame, Saïd Ahmaidi
The aim of this study was to evaluate the reproducibility and validity of the "Footeval" test, which evaluates football players' aerobic level in conditions close to those of football practice (intermittent, including technical skills). Twenty-four highly trained subjects from an elite football academy (17.8 ± 1.4 years, 5 training sessions per week) performed two Footeval sessions in a period of 7 days. Physiological variables measured during these sessions (VO2max 58.1 ± 5.6 and 58.7 ± 6.2 ml·min(-1)·kg(-1); RER 1...
December 2016: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/27916643/homeostatic-effects-of-exercise-and-sleep-on-metabolic-processes-in-mice-with-an-overexpressed-skeletal-muscle-clock
#11
Allison J Brager, Lydia Heemstra, Raman Bhambra, J Christopher Ehlen, Karyn A Esser, Ketema N Paul, Colleen M Novak
Brain and muscle-ARNT-like factor (Bmal1/BMAL1) is an essential transcriptional/translational factor of circadian clocks. Loss of function of Bmal1/BMAL1 is highly disruptive to physiological and behavioral processes. In light of these previous findings, we examined if transgenic overexpression of Bmal1/BMAL1 in skeletal muscle could alter metabolic processes. First, we characterized in vivo and ex vivo metabolic phenotypes of muscle overexpressed mice (male and female) compared to wild-type littermates (WT)...
January 2017: Biochimie
https://www.readbyqxmd.com/read/27914920/can-lowering-the-guidance-force-of-robot-assisted-gait-training-induce-a-sufficient-metabolic-demand-in-subacute-dependent-ambulatory-stroke-patients
#12
So Young Lee, Eun Young Han, Bo Ryun Kim, Min Ho Chun, Yong Ki Lee
OBJECTIVE: To assess the effects of guidance force (GF) and gait speed (GS) on cardiorespiratory responses and energy cost in subacute dependent ambulatory stroke patients. DESIGN: Cross sectional study. SETTING: University rehabilitation hospital. PARTICIPANTS: Ten subacute stroke patients (mean age: 64.50±19.20), who were dependent ambulators (functional ambulation category [FAC] ≤2). INTERVENTIONS: Patients participated in cardiorespiratory tests during robot-assisted gait training...
November 30, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27871814/dr-alois-huger-laying-the-foundations-for-an-integrated-insect-pathology
#13
Trevor A Jackson
Dr. Rer. Nat. Alois M. Huger had a long and distinguished career at the Institut für biologische Schädlingsbekämpfung (Institute for Biological Pest Control) Darmstadt, Germany, where he became one of the world's leading insect pathologists. He applied his experience and understanding of insect tissues and specialist skills in microscopy to diagnosis and elucidation of the pathology of insect diseases. During his career he discovered the Oryctes nudivirus and Bacillus thuringiensis subsp. tenebrionis, and was a member of teams unravelling amber disease in scarab beetles and the role of bacteria in parthenogenesis of parasitoids...
November 18, 2016: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/27869096/predictive-factor-analysis-of-response-adapted-radiation-therapy-for-chemotherapy-sensitive-pediatric-hodgkin-lymphoma-analysis-of-the-children-s-oncology-group-ahod-0031-trial
#14
Anne-Marie Charpentier, Debra L Friedman, Suzanne Wolden, Cindy Schwartz, Bethany Gill, Jenna Sykes, Alisha Albert-Green, Kara M Kelly, Louis S Constine, David C Hodgson
PURPOSE: To evaluate whether clinical risk factors could further distinguish children with intermediate-risk Hodgkin lymphoma (HL) with rapid early and complete anatomic response (RER/CR) who benefit significantly from involved-field RT (IFRT) from those who do not, and thereby aid refinement of treatment selection. METHODS AND MATERIALS: Children with intermediate-risk HL treated on the Children's Oncology Group AHOD 0031 trial who achieved RER/CR with 4 cycles of chemotherapy, and who were randomized to 21-Gy IFRT or no additional therapy (n=716) were the subject of this study...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27863384/a-novel-highly-potent-trivalent-tgf-%C3%AE-receptor-trap-inhibits-early-stage-tumorigenesis-and-tumor-cell-invasion-in-murine-pten-deficient-prostate-glands
#15
Tai Qin, Lindsey Barron, Lu Xia, Haojie Huang, Maria M Villarreal, John Zwaagstra, Cathy Collins, Junhua Yang, Christian Zwieb, Ravindra Kodali, Cynthia S Hinck, Sun Kyung Kim, Robert L Reddick, Chang Shu, Maureen D O'Connor-McCourt, Andrew P Hinck, Lu-Zhe Sun
The effects of transforming growth factor beta (TGF-β) signaling on prostate tumorigenesis has been shown to be strongly dependent on the stage of development, with TGF-β functioning as a tumor suppressor in early stages of disease and as a promoter in later stages. To study in further detail the paradoxical tumor-suppressive and tumor-promoting roles of the TGF-β pathway, we investigated the effect of systemic treatment with a TGF-β inhibitor on early stages of prostate tumorigenesis. To ensure effective inhibition, we developed and employed a novel trivalent TGF-β receptor trap, RER, comprised of domains derived from the TGF-β type II and type III receptors...
November 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27851893/caffeine-influences-cadence-at-lower-but-not-higher-intensity-rpe-regulated-cycling
#16
J Matt Green, Alyssa Olenick, Caroline Eastep, Lee Winchester
: Caffeine blunts RPE estimations but effects on selected cycling cadence are unclear. PURPOSE: This study examined influence of caffeine on cycling cadence with intensities prescribed at RPE 4 and 7 (OMNI Scale). METHODS: College-aged (20.5±2.0y) male and female volunteers (n=15) (VO2 peak=40.3±4.0,) completed a maximal cycling test followed by trials where they adjusted cadence (CAD) (clamped resistances) to produce overall feelings equivalent to RPE 4 (RPE4) and RPE 7 (RPE7) (10min each) following caffeine (CAF) (6mg·kg(-1)·min(-1)) and placebo (PLA) (counterbalanced) ingestion...
February 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/27849117/metabolic-responses-to-a-loaded-movement-training-workout
#17
Derek N Vandenbrink, Nicholas J Petrella, Eric V Neufeld, Brett A Dolezal, Daniel P Maclennan
BACKGROUND: Few studies have investigated the metabolic demands of functional exercise. We determined the oxygen cost, heart rate (HR) response, and energy expenditure (EE) both during and immediately following a loaded movement training (LMT) workout. METHODS: Ten participants (5 male, age = 23.5 ± 3.7 years, VO2peak = 53.3 ± 6.4 ml∙kg-1∙min- 1) completed baseline resting metabolic rate testing, a maximal oxygen uptake (VO2) test, and a familiarization trial...
November 16, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27824689/eccentric-cycling-a-promising-modality-for-patients-with-chronic-heart-failure
#18
Lauren C Chasland, Daniel J Green, Andrew J Maiorana, Kazunori Nosaka, Andrew Haynes, Lawrence Dembo, Louise H Naylor
INTRODUCTION: Chronic heart failure (CHF) is characterized by dyspnea and poor exercise tolerance, which decreases aerobic capacity (V˙O2peak), a measure strongly correlated with quality of life and mortality. In healthy populations, eccentric (ECC) cycling can be performed at a lower oxygen demand for matched workload, compared to concentric (CON) cycling, but few studies have previously investigated ECC cycling in CHF. We hypothesized that, when matched for external workload (Watts), an ECC cycling bout would be performed at a lower cardiorespiratory load (V˙O2) than CON in patients with CHF...
November 7, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27810701/breast-cancer-diagnosis-and-mortality-by-tumor-stage-and-migration-background-in-a-nationwide-cohort-study-in-sweden
#19
Gholamreza Abdoli, Matteo Bottai, Kerstin Sandelin, Tahereh Moradi
INTRODUCTION: Survival in breast cancer patients has steadily increased over the years, but with considerable disparities between individuals with different migration background and social position. We explored differences in diagnosis and all-cause mortality in breast cancer patients by stage of disease at the time of diagnosis and by country of birth, while considering the effect of comorbidity, regional and socio-demographic factors. METHODS: We used Swedish national registers to follow a cohort of 35,268 patients (4232 foreign-born) with breast cancer between 2004 and 2009 in Sweden...
February 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27806012/acute-effects-of-plyometric-and-resistance-training-on-running-economy-in-trained-runners
#20
Richard T Marcello, Beau Kjerulf Greer, Anna E Greer
Results regarding the acute effects of plyometric and resistance training (PRT) on running economy (RE) are conflicting. Eight male collegiate distance runners (21 ± 1 years, 62.5 ± 7.8 ml/kg/min V[Combining Dot Above]O2 peak) completed V[Combining Dot Above]O2 peak and 1 repetition maximum (1RM) testing. Seven days later, subjects completed a 12 minute RE test at 60% and 80% V[Combining Dot Above]O2 peak, followed by a PRT protocol or a rested condition of equal duration (CON). The PRT protocol consisted of 3 sets of 5 repetitions at 85% 1RM for barbell squats, Romanian deadlifts, and barbell lunges; the same volume was utilized for resisted lateral lunges, box jumps, and depth jumps...
October 28, 2016: Journal of Strength and Conditioning Research
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