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Respiratory exchange ratio

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https://www.readbyqxmd.com/read/28416899/the-efficacy-of-a-discontinuous-graded-exercise-test-in-measuring-peak-oxygen-uptake-in-children-aged-8-to-10-years
#1
D Lambrick, J Jakeman, R Grigg, S Kaufmann, J Faulkner
As children's natural activity patterns are highly intermittent in nature, and characterised by rapid changes from rest to vigorous physical activity, discontinuous exercise tests may be considered ecologically valid for this population group. This study compared the peak physiological responses from a discontinuous and continuous graded exercise test (GXT_D, GXT_C, respectively) during treadmill exercise in children. Twenty-one healthy children (9.6 ± 0.6 y) completed GXT_D and GXT_C in a randomised order, separated by 72-hours...
March 2017: Biology of Sport
https://www.readbyqxmd.com/read/28408022/left-ventricular-assist-device-as-a-bridge%C3%A2-to-recovery-for-patients-with-advanced-heart-failure
#2
Djordje G Jakovljevic, Magdi H Yacoub, Stephan Schueler, Guy A MacGowan, Lazar Velicki, Petar M Seferovic, Sandeep Hothi, Bing-Hsiean Tzeng, David A Brodie, Emma Birks, Lip-Bun Tan
BACKGROUND: Left ventricular assist devices (LVADs) have been used as an effective therapeutic option in patients with advanced heart failure, either as a bridge to transplantation, as destination therapy, or in some patients, as a bridge to recovery. OBJECTIVES: This study evaluated whether patients undergoing an LVAD bridge-to-recovery protocol can achieve cardiac and physical functional capacities equivalent to those of healthy controls. METHODS: Fifty-eight male patients-18 implanted with a continuous-flow LVAD, 16 patients with LVAD explanted (recovered patients), and 24 heart transplant candidates (HTx)-and 97 healthy controls performed a maximal graded cardiopulmonary exercise test with continuous measurements of respiratory gas exchange and noninvasive (rebreathing) hemodynamic data...
April 18, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28407668/type-2-diabetes-is-associated-with-lower-cardiorespiratory-fitness-independent-of-pulmonary-function-in-severe-obesity
#3
Britta Wilms, Barbara Ernst, Martin Thurnheer, Christina M Spengler, Bernd Schultes
Both severe obesity and type 2 diabetes (T2DM) are associated with reduced pulmonary function and reduced cardiorespiratory fitness. We investigated whether T2DM further aggravates the impaired pulmonary function and cardiorespiratory fitness in subjects with severe obesity. In this cross-sectional study pulmonary function (forced expiratory volume within 1 s, FEV1; vital capacity, VC) was assessed in 65 severely obese subjects with T2DM (T2DM group) and 65 severely obese subjects without T2DM (non-T2DM group), pairwise matched for sex, age, weight, and height...
April 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28400503/pgc-1%C3%AE-and-fasting-induced-pdh-regulation-in-mouse-skeletal-muscle
#4
Anders Gudiksen, Henriette Pilegaard
The purpose of the present study was to examine whether lack of skeletal muscle peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) affects the switch in substrate utilization from a fed to fasted state and the fasting-induced pyruvate dehydrogenase (PDH) regulation in skeletal muscle. Skeletal muscle-specific PGC-1α knockout (MKO) mice and floxed littermate controls were fed or fasted for 24 h. Fasting reduced PDHa activity, increased phosphorylation of all four known sites on PDH-E1α and increased pyruvate dehydrogenase kinase (PDK4) and sirtuin 3 (SIRT3) protein levels, but did not alter total acetylation of PDH-E1α Lack of muscle PGC-1α did not affect the switch from glucose to fat oxidation in the transition from the fed to fasted state, but was associated with lower and higher respiratory exchange ratio (RER) in the fed and fasted state, respectively...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28396263/stable-isotope-analysis-of-co2-in-breath-indicates-metabolic-fuel-shifts-in-torpid-arctic-ground-squirrels
#5
Trixie N Lee, Melanie M Richter, Cory T Williams, Øivind Tøien, Brian M Barnes, Diane M O'Brien, C Loren Buck
Stable carbon isotope ratios (δ(13)C) in breath show promise as an indicator of immediate metabolic fuel utilization in animals because tissue lipids have a lower δ(13)C value than carbohydrates and proteins. Metabolic fuel consumption is often estimated using the respiratory exchange ratio (RER), which has lipid and carbohydrate boundaries, but does not differentiate between protein and mixed fuel catabolism at intermediate values. Because lipids have relatively low δ(13)C values, measurements of stable carbon isotopes in breath may help distinguish between catabolism of protein and mixed fuel that includes lipid...
April 7, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28386795/-metabolic-and-cardiovascular-response-to-exercise-in-patients-with-type-1-diabetes
#6
I Turinese, P Marinelli, M Bonini, M Rossetti, G Statuto, T Filardi, A Paris, A Lenzi, S Morano, P Palange
PURPOSE: Physical activity is an effective therapeutic tool for cardiovascular risk prevention. However, exercise aerobic capacity of patients with type 1 diabetes (T1DM) has not been thoroughly investigated. Aim of the present study is to evaluate exercise aerobic capacity in patients with T1DM compared to a normal control population. METHODS: This observational study included 17 T1DM patients and 17 matched healthy volunteers. Cardiopulmonary exercise test (CPET) was conducted on an electronically-braked cycle ergometer...
April 6, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28386556/effects-of-high-intensity-interval-training-on-aerobic-capacity-in-cardiac-patients-a-systematic-review-with-meta-analysis
#7
Bin Xie, Xianfeng Yan, Xiangna Cai, Jilin Li
Purpose. The aim of this study was to compare the effects of high-intensity interval training (INTERVAL) and moderate-intensity continuous training (CONTINUOUS) on aerobic capacity in cardiac patients. Methods. A meta-analysis identified by searching the PubMed, Cochrane Library, EMBASE, and Web of Science databases from inception through December 2016 compared the effects of INTERVAL and CONTINUOUS among cardiac patients. Results. Twenty-one studies involving 736 participants with cardiac diseases were included...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28382972/bio-inspired-murray-materials-for-mass-transfer-and-activity
#8
Xianfeng Zheng, Guofang Shen, Chao Wang, Yu Li, Darren Dunphy, Tawfique Hasan, C Jeffrey Brinker, Bao-Lian Su
Both plants and animals possess analogous tissues containing hierarchical networks of pores, with pore size ratios that have evolved to maximize mass transport and rates of reactions. The underlying physical principles of this optimized hierarchical design are embodied in Murray's law. However, we are yet to realize the benefit of mimicking nature's Murray networks in synthetic materials due to the challenges in fabricating vascularized structures. Here we emulate optimum natural systems following Murray's law using a bottom-up approach...
April 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28356130/parecoxib-reduced-ventilation-induced-lung-injury-in-acute-respiratory-distress-syndrome
#9
Fan-You Meng, Wei Gao, Ying-Nan Ju
BACKGROUND: Cyclooxygenase-2 (COX-2) contributes to ventilation induced lung injury (VILI) and acute respiratory distress syndrome (ARDS). The objective of present study was to observe the therapeutic effect of parecoxib on VILI in ARDS. METHODS: In this parallel controlled study performed at Harbin Medical University, China between January 2016 and March 2016, 24 rats were randomly allocated into sham group (S), volume ventilation group/ARDS (VA), parecoxib/volume ventilation group/ARDS (PVA)...
March 29, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28347790/key-conceptional-considerations-on-nebulization-of-antimicrobial-agents-to-mechanically-ventilated-patients
#10
Jordi Rello, Jean Jacques Rouby, Candela Sole-Lleonart, Jean Chastre, Stijn Blot, Charles Edouard Luyt, Jordi Riera, Margreet C Vos, Antoine Monsel, Jayesh Dhanani, Jason A Roberts
Nebulized antibiotics have an established role in patients with cystic fibrosis or bronchiectasis. Their potential benefit to treat respiratory infections in mechanically ventilated patients is receiving increasing interest. In this Consensus Paper of the European Society of Clinical Microbiology and Infectious Diseases, the body of evidence of the therapeutic utility of aerosolized antibiotics in mechanically ventilated patients was reviewed and resulted in the following recommendations: A. Vibrating mesh nebulizers should be preferred to jet or ultrasonic nebulizers; B...
March 24, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28346316/impact-of-direction-of-unloading-influence-on-template-rate-of-perceived-exertion
#11
Beau Kjerulf Greer, Patrick R Young, Brooke Thompson, Brendan J Rickert, Matthew F Moran
It is suggested that exercisers engage in a process of teleoanticipation and create an exercise template based upon previous experience with the exercise task which guides their perceptions of the amount of effort required for task completion. The present study examined how altering workload intensity during a positive-pressure treadmill task may impact ratings of perceived exertion (RPE). In a counter-balanced design, 15 collegiate cross country runners (7 males, 8 females) performed two 25-min runs at a constant velocity while bodyweight (BW) was either increased from 60% to 100% (INC) or decreased from 100% to 60% (DEC) in 5 min increments...
March 23, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28340236/diet-density-during-the-first-week-of-life-effects-on-energy-and-nitrogen-balance-characteristics-of-broiler-chickens
#12
D M Lamot, D Sapkota, P J A Wijtten, I van den Anker, M J W Heetkamp, B Kemp, H van den Brand
This study aimed to determine effects of diet density on growth performance, energy balance, and nitrogen balance characteristics of broiler chickens during the first wk of life. Effects of diet density were studied using a dose-response design consisting of 5 dietary fat levels (3.5, 7.0, 10.5, 14.0, and 17.5%). The relative difference in dietary energy level was used to increase amino acid levels, mineral levels, and the premix inclusion level at the same ratio. Chickens were housed in open-circuit climate respiration chambers from d 0 to 7 after hatch...
March 11, 2017: Poultry Science
https://www.readbyqxmd.com/read/28328860/ventilation-during-cardiopulmonary-bypass-for-prevention-of-respiratory-insufficiency-a-meta-analysis-of-randomized-controlled-trials
#13
Dongmei Chi, Chan Chen, Yu Shi, Wanyu Wang, Ye Ma, Ronghua Zhou, Hai Yu, Bin Liu
BACKGROUND: Cardiopulmonary bypass (CPB) is necessary for most cardiac surgery, which may lead to postoperative lung injury. The objective of this paper is to systematically evaluate whether ventilation during CPB would benefit patients undergoing cardiac surgery. METHODS: We searched randomized controlled trials (RCTs) through PubMed, Embase, and Cochrane Library from inception to October 2016. Eligible studies compared clinical outcomes of ventilation versus nonventilation during CPB in patients undergoing cardiac surgery...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28319140/role-of-muscle-il-6-in-gender-specific-metabolism-in-mice
#14
Amalia Molinero, Antonio Fernandez-Perez, Aina Mogas, Mercedes Giralt, Gemma Comes, Olaya Fernandez-Gayol, Mario Vallejo, Juan Hidalgo
The aim of the present work was to further explore the physiological roles of muscle-derived IL-6. Adult-floxed and conditional skeletal muscle IL-6 knock out male and female mice were used to study energy expenditure (indirect calorimetry at rest and during treadmill exercise, and body temperature cycle during the light phase) and energy intake (response to fast/refeeding). We also evaluated the responses to leptin and the activity of the insulin signalling pathway in skeletal muscle and liver by phosphorylation of Akt at Ser 473...
2017: PloS One
https://www.readbyqxmd.com/read/28283993/development-and-validity-of-the-rating-of-fatigue-scale
#15
D Micklewright, A St Clair Gibson, V Gladwell, A Al Salman
OBJECTIVE: The purpose of these experiments was to develop a rating-of-fatigue (ROF) scale capable of tracking the intensity of perceived fatigue in a variety of contexts. METHODS: Four experiments were carried out. The first provided the evidential basis for the construction of the ROF scale. The second tested the face validity of the ROF, and the third tested the convergent and divergent validity of the ROF scale during ramped cycling to exhaustion and 30 min of resting recovery...
March 10, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28255088/oral-n-acetylcysteine-and-exercise-tolerance-in-mild-chronic-obstructive-pulmonary-disease
#16
Daniel M Hirai, Joshua H Jones, Joel T Zelt, Marianne L da Silva, Robert F Bentley, Brittany Ann Edgett, Brendon James Gurd, Michael E Tschakovsky, Denis E O'Donnell, J Alberto Neder
Heightened oxidative stress is implicated in the progressive impairment of skeletal muscle vascular and mitochondrial function in chronic obstructive pulmonary disease (COPD). Whether accumulation of reactive oxygen species contribute to exercise intolerance in the early stages of COPD is unknown. We examined the effects of oral antioxidant treatment with N-acetylcysteine (NAC) on respiratory, cardiovascular and locomotor muscle function and exercise tolerance in patients with mild COPD. Thirteen patients with forced expiratory volume in one second and forced vital capacity ratio (FEV1/FVC) < lower limit of normal (LLN) and FEV1 ≥ LLN were enrolled in a double-blind, randomized crossover study to receive NAC (1800 mg/day) or placebo for 4 days...
March 2, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28246337/diacylglycerol-kinase-%C3%AF%C2%B5-deficiency-preserves-glucose-tolerance-and-modulates-lipid-metabolism-in-obese-mice
#17
Louise Mannerås-Holm, Milena Schönke, Joseph T Brozinick, Laurène Vetterli, Hai-Hoang Bui, Philip Sanders, Emmani B M Nascimento, Marie Björnholm, Alexander V Chibalin, Juleen R Zierath
Diacylglycerol kinases (DGKs) catalyze the phosphorylation and conversion of DAG into phosphatidic acid. DGK isozymes have unique primary structures, expression patterns, subcellular localizations, regulatory mechanisms and DAG preferences. DGKε has a hydrophobic segment that promotes its attachment to membranes and shows substrate specificity for DAG with an arachidonoyl acyl chain in the sn-2 position of the substrate. We determined the role of DGKε in the regulation of energy and glucose homeostasis in relation to diet-induced insulin resistance and obesity using DGKε deficient (KO) and wild-type mice...
February 28, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28229577/maximal-aerobic-capacity-can-be-increased-by-enhancing-performers-expectancies
#18
Jeff Montes, Gabriele Wulf, James W Navalta
BACKGROUND: Maximum aerobic capacity (VO2max) is widely accepted as the best measure of cardiovascular fitness and aerobic power. The present study investigated whether enhancing participants' performance expectancies through positive social-comparative feedback would increase VO2max. METHODS: Participants were experienced runners who regularly ran for exercise or competitively. All participants completed two VO2max tests within a 2-week period at similar times of the day...
February 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28211258/effects-of-a-wide-range-of-dietary-nicotinamide-riboside-nr-concentrations-on-metabolic-flexibility-and-white-adipose-tissue-wat-of-mice-fed-a-mildly-obesogenic-diet
#19
Wenbiao Shi, Maria A Hegeman, Dorien A M van Dartel, Jing Tang, Manuel Suarez, Hans Swarts, Bart van der Hee, Lluis Arola, Jaap Keijer
SCOPE: Metabolic flexibility is the ability to switch metabolism between carbohydrate oxidation (CHO) and fatty acid oxidation (FAO) and is a biomarker for metabolic health. The effect on metabolic health of nicotinamide riboside (NR) as an exclusive source of vitamin B3 is unknown and is examined here for a wide range of NR. DESIGN AND METHODS: Nine-week-old male C57BL/6JRcc mice received a semi-purified mildly obesogenic (40 en% fat) diet containing 0.14% L-tryptophan and either 5, 15, 30, 180, or 900 mg NR per kg diet for 15 weeks...
February 16, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28211029/influence-of-segmental-body-composition-and-adiposity-hormones-on-resting-metabolic-rate-and-substrate-utilization-in-overweight-and-obese-adults
#20
K R Hirsch, A E Smith-Ryan, M N M Blue, M G Mock, E T Trexler
PURPOSE: Low resting metabolic rate (RMR) and high carbohydrate reliance at rest are associated with weight gain, but are highly variable in obese individuals. This study determined the relationship of total and segmental body composition and adiposity hormones with RMR and respiratory exchange ratio (RER) in overweight and obese adults. METHODS: In 49 men (n = 23) and premenopausal women (n = 26) [mean ± SD; age = 35.0 ± 8.9 years; body mass index (BMI) = 33...
February 16, 2017: Journal of Endocrinological Investigation
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