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Oxygen deficit in performance

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https://www.readbyqxmd.com/read/29656905/transcranial-direct-current-stimulation-improves-long-term-memory-deficits-in-an-animal-model-of-attention-deficit-hyperactivity-disorder-and-modulates-oxidative-and-inflammatory-parameters
#1
Douglas Teixeira Leffa, Bruna Bellaver, Artur Alban Salvi, Carla de Oliveira, Wolnei Caumo, Eugenio Horacio Grevet, Felipe Fregni, André Quincozes-Santos, Luis Augusto Rohde, Iraci L S Torres
BACKGROUND: Transcranial direct current stimulation (tDCS) is a technique that modulates neuronal activity and has been proposed as a potential therapeutic tool for attention-deficit/hyperactivity disorder (ADHD) symptoms. Although pilot studies have shown evidence of efficacy, its mechanism of action remains unclear. OBJECTIVE/HYPOTHESIS: We evaluated the effects of tDCS on behavioral (working and long-term memory) and neurochemical (oxidative and inflammatory parameters) outcomes related to ADHD pathophysiology...
April 5, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29605442/intranasal-administration-of-sodium-dimethyldithiocarbamate-induces-motor-deficits-and-dopaminergic-dysfunction-in-mice
#2
Josiel M Mack, Tainara M Moura, Débora Lanznaster, Franciane Bobinski, Caio M Massari, Tuane B Sampaio, Ariana E Schmitz, Luiz F Souza, Roger Walz, Carla I Tasca, Anicleto Poli, Richard L Doty, Alcir L Dafre, Rui D Prediger
The primary etiology of Parkinson's disease (PD) remains unclear, but likely reflects a combination of genetic and environmental factors. Exposure to some pesticides, including ziram (zinc dimethyldithiocarbamate), is a relevant risk factor for PD. Like some other environmental neurotoxicants, we hypothesized that ziram can enter the central nervous system from the nasal mucosa via the olfactory nerves. To address this issue, we evaluated the effects of 1, 2 or 4 days of intranasal (i.n., 1 mg/nostril/day) infusions of sodium dimethyldithiocarbamate (NaDMDC), a dimethyldithiocarbamate more soluble than ziram, on locomotor activity in the open field, neurological severity score and rotarod performance...
March 29, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29604488/prefrontal-over-activation-during-walking-in-people-with-mobility-deficits-interpretation-and-functional-implications
#3
Kelly A Hawkins, Emily J Fox, Janis J Daly, Dorian K Rose, Evangelos A Christou, Theresa E McGuirk, Dana M Otzel, Katie A Butera, Sudeshna A Chatterjee, David J Clark
BACKGROUND: Control of walking by the central nervous system includes contributions from executive control mechanisms, such as attention and motor planning resources. Executive control of walking can be estimated objectively by recording prefrontal cortical activity using functional near infrared spectroscopy (fNIRS). OBJECTIVE: The primary objective of this study was to investigate group differences in prefrontal/executive control of walking among young adults, older adults, and adults post-stroke...
March 28, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29602494/motor-coordination-and-synaptic-plasticity-deficits-are-associated-with-increased-cerebellar-activity-of-nadph-oxidase-camkii-and-pkc-at-preplaque-stage-in-the-tgcrnd8-mouse-model-of-alzheimer-s-disease
#4
Roberto Russo, Fabio Cattaneo, Pellegrino Lippiello, Claudia Cristiano, Fabio Zurlo, Martina Castaldo, Carlo Irace, Tiziana Borsello, Rita Santamaria, Rosario Ammendola, Antonio Calignano, Maria Concetta Miniaci
Numerous studies indicate that the cerebellum undergoes structural and functional neurodegenerative changes in Alzheimer's disease. The purpose of this study was to examine the extent of cerebellar alterations at early, preplaque stage of the pathology in TgCRND8 mice through behavioral, electrophysiological, and molecular analysis. Balance beam test and foot-printing analysis revealed significant motor coordination and balance deficits in 2-month-old TgCRND8 mice compared to their littermates. Patch-clamp recordings performed on cerebellar slices of transgenic mice showed synaptic plasticity deficit and loss of noradrenergic modulation at parallel fiber-Purkinje cell synapse suggesting an early dysfunction of the cerebellar circuitry due to amyloid precursor protein overexpression...
March 5, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29600726/aerobic-with-resistance-training-or-aerobic-training-alone-poststroke-a-secondary-analysis-from-a-randomized-clinical-trial
#5
Susan Marzolini, Dina Brooks, Paul Oh, David Jagroop, Bradley J MacIntosh, Nicole D Anderson, David Alter, Dale Corbett
BACKGROUND: Stroke is associated with muscle atrophy and weakness, mobility deficits, and cardiorespiratory deconditioning. Aerobic and resistance training (AT and RT) each have the potential to improve deficits, yet there is limited evidence on the utility of combined training. OBJECTIVE: To examine the effects of AT+RT versus AT on physiological outcomes in chronic stroke with motor impairments. METHODS: Participants (n = 73) were randomized to 6 months of AT (5 d/wk) or AT+RT (3 and 2 d/wk, respectively)...
March 1, 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29587242/anthocyanins-as-a-potential-pharmacological-agent-to-manage-memory-deficit-oxidative-stress-and-alterations-in-ion-pump-activity-induced-by-experimental-sporadic-dementia-of-alzheimer-s-type
#6
Simone Muniz Pacheco, Mayara Sandrielly Pereira Soares, Jessié Martins Gutierres, Mariana Freire Barbieri Gerzson, Fabiano Barbosa Carvalho, Juliana Hofstatter Azambuja, Maria Rosa Chitolina Schetinger, Francieli Moro Stefanello, Roselia Maria Spanevello
Anthocyanins (ANT) are polyphenolic flavonoids with antioxidant and neuroprotective properties. This study evaluated the effect of ANT treatment on cognitive performance and neurochemical parameters in an experimental model of sporadic dementia of Alzheimer's type (SDAT). Adult male rats were divided into four groups: control (1 ml/kg saline, once daily, by gavage), ANT (200 mg/kg, once daily, by gavage), streptozotocin (STZ, 3 mg/kg) and STZ plus ANT. STZ was administered via bilateral intracerebroventricular (ICV) injection (5 μl)...
February 27, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29581965/involvement-of-cholinergic-dysfunction-and-oxidative-damage-in-the-effects-of-simulated-weightlessness-on-learning-and-memory-in-rats
#7
Yongliang Zhang, Qiong Wang, Hailong Chen, Xinmin Liu, Ke Lv, Tingmei Wang, Yanli Wang, Guohua Ji, Hongqing Cao, Guanghan Kan, Yinghui Li, Lina Qu
The present study aimed to determine how the learning and memory gradually change with the prolonged hindlimb unloading (HU) treatment in rats. Different HU durations (7 d, 14 d, 21 d, and 28 d) in Sprague-Dawley (SD) rats were implemented. Cognitive function was assessed using the Morris water maze (MWM) and the shuttle box test. Additionally, parameters about cholinergic activity and oxidative stress were tested. Results showed that longer-than-14 d HU led to the inferior performances in the behavioral tasks...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29566090/aerobic-fitness-in-professional-soccer-players-after-anterior-cruciate-ligament-reconstruction
#8
Adriano Marques de Almeida, Paulo Roberto Santos Silva, André Pedrinelli, Arnaldo J Hernandez
Although anterior cruciate ligament (ACL) reconstruction is considered a successful procedure in restoring knee stability, few studies have addressed the issue of aerobic capacity after ACL surgery. Soccer players need technical, tactical and physical skills to succeed, such as good knee function and aerobic capacity. Our purpose is to evaluate aerobic fitness in ACL injured professional football players and six months after ACL reconstruction compared to a control group. Twenty athletes with ACL injury were evaluated and underwent ACL reconstruction with hamstrings autograft, and were compared to twenty healthy professional soccer players...
2018: PloS One
https://www.readbyqxmd.com/read/29549119/the-case-for-early-use-of-rapid-whole-genome-sequencing-in-management-of-critically-ill-infants-late-diagnosis-of-coffin-siris-syndrome-in-an-infant-with-left-congenital-diaphragmatic-hernia-congenital-heart-disease-and-recurrent-infections
#9
Nathaly M Sweeney, Shareef A Nahas, Shimul Chowdhury, Miguel Del Campo, Marilyn C Jones, David P Dimmock, Stephen F Kingsmore, Rcigm Investigators
Congenital diaphragmatic hernia (CDH) results from incomplete formation of the diaphragm leading to herniation of abdominal organs into the thoracic cavity. CDH is associated with pulmonary hypoplasia, congenital heart disease and pulmonary hypertension. Genetically, it is associated with aneuploidies, chromosomal copy number variants, and single gene mutations. CDH is the most expensive non-cardiac congenital defect: Management frequently requires implementation of Extracorporeal Membrane Oxygenation (ECMO), which increases management expenditures 2...
March 16, 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29537670/impaired-decision-making-and-functional-neuronal-network-activity-in-systemic-lupus-erythematosus
#10
Bei-Bei Wu, Ye Ma, Lei Xie, Jin-Zhuang Huang, Zong-Bo Sun, Zhi-Duo Hou, Rui-Wei Guo, Zhi-Rong Lin, Shou-Xing Duan, Shan-Shan Zhao, Yao-Xie, Dan-Miao Sun, Chun-Min Zhu, Shu-Hua Ma
BACKGROUND: Systemic lupus erythematosus (SLE) is associated with cognitive deficit but the exact neural mechanisms remain unclear. PURPOSE: To explore sequential brain activities using functional magnetic resonance imaging (fMRI) during the performance of a decision-making task, and to determine whether serum or clinical markers can reflect the involvement of the brain in SLE. SUBJECTS: Sixteen female SLE patients without overt clinical neuropsychiatric symptoms and 16 healthy controls were included...
March 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29521586/upregulation-of-mir-216a-exerts-neuroprotective-effects-against-ischemic-injury-through-negatively-regulating-jak2-stat3-involved-apoptosis-and-inflammatory-pathways
#11
Yu Shuang Tian, Di Zhong, Qing Qing Liu, Xiu Li Zhao, Hong Xue Sun, Jing Jin, Hai Ning Wang, Guo Zhong Li
OBJECTIVE Ischemic stroke remains a significant cause of death and disability in industrialized nations. Janus tyrosine kinase (JAK) and signal transducer and activator of transcription (STAT) of the JAK2/STAT3 pathway play important roles in the downstream signal pathway regulation of ischemic stroke-related inflammatory neuronal damage. Recently, microRNAs (miRNAs) have emerged as major regulators in cerebral ischemic injury; therefore, the authors aimed to investigate the underlying molecular mechanism between miRNAs and ischemic stroke, which may provide potential therapeutic targets for ischemic stroke...
March 9, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29466079/passive-recovery-reduces-fatigue-during-repeated-change-of-direction-sprints-in-basketball-players
#12
Maria C Madueno, Vincent J Dalbo, Joshua H Guy, Kate E Giamarelos, Tania Spiteri, Aaron T Scanlan
PURPOSE: To investigate the physiological and performance effects of active and passive recovery between repeated-change-of-direction (RCOD) sprints. METHODS: Eight semi-professional basketball players (age: 19.9 ± 1.5 yr; stature: 183.0 ± 9.6 cm; body mass: 77.7 ± 16.9 kg; body fat: 11.8 ± 6.3%; VO2peak : 46.1 ± 7.6 mL·kg-1 ·min-1 ) completed 12 x 20-m RCOD sprints (Agility 5-0-5 Tests) interspersed with 20 s of active (50% maximal aerobic speed) or passive recovery in a randomized cross-over design...
February 21, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29362707/decrease-in-pulmonary-function-and-oxygenation-after-lung-resection
#13
Barbara Cristina Brocki, Elisabeth Westerdahl, Daniel Langer, Domingos S R Souza, Jan Jesper Andreasen
Respiratory deficits are common following curative intent lung cancer surgery and may reduce the patient's ability to be physically active. We evaluated the influence of surgery on pulmonary function, respiratory muscle strength and physical performance after lung resection. Pulmonary function, respiratory muscle strength (maximal inspiratory/expiratory pressure) and 6-min walk test (6MWT) were assessed pre-operatively, 2 weeks post-operatively and 6 months post-operatively in 80 patients (age 68±9 years)...
January 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29351000/age-effects-on-cerebral-oxygenation-and-behavior-in-children-with-sleep-disordered-breathing
#14
Knarik Tamanyan, Lisa M Walter, Aidan Weichard, Margot J Davey, Gillian M Nixon, Sarah N Biggs, Rosemary Sc Horne
RATIONALE: Childhood sleep disordered breathing ranges in severity from primary snoring to obstructive sleep apnea and is associated with behavioral and neurocognitive deficits. It remains unknown why children with primary snoring, who do not experience peripheral oxygen desaturation or sleep fragmentation, experience similar daytime deficits as those with obstructive sleep apnea or why effects are age dependent. OBJECTIVE: To examine cerebral tissue oxygenation and oxygen extraction as an explanation for daytime deficits in children with primary snoring...
January 19, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29346315/dietary-total-prenylflavonoids-from-the-fruits-of-psoralea-corylifolia-l-prevents-age-related-cognitive-deficits-and-down-regulates-alzheimer-s-markers-in-samp8-mice
#15
Zhi-Jing Chen, Yan-Fang Yang, Ying-Tao Zhang, Dong-Hui Yang
Alzheimer's disease (AD) is a serious threat for the aging society. In this study, we examined the preventive effect of the total prenylflavonoids (TPFB) prepared from the dried fruits of Psoralea corylifolia L., using an age-related AD mouse model SAMP8. We found that long-term dietary TPFB at 50 mg/kg·day significantly improved cognitive performance of the SAMP8 mice in Morris water maze tests, similar to 150 mg/kg·day of resveratrol, a popular neuro-protective compound. Furthermore, TPFB treatment showed significant improvements in various AD markers in SAMP8 brains, which were restored to near control levels of the normal mice, SAMR1...
January 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29327228/postoperative-intermittent-fasting-prevents-hippocampal-oxidative-stress-and-memory-deficits-in-a-rat-model-of-chronic-cerebral-hypoperfusion
#16
Yuan Hu, Miao Zhang, Yunyun Chen, Ying Yang, Jun-Jian Zhang
PURPOSE: Whether intermittent fasting (IF) treatment after stroke can prevent its long-term detrimental effects remains unknown. Here, we investigate the effects of postoperative IF on cognitive deficits and its underlying mechanisms in a permanent two-vessel occlusion (2VO) vascular dementia rat model. METHODS: Rats were subjected to either IF or ad libitum feeding 1 week after 2VO surgery. The cognition of rats was assessed using the novel object recognition (NOR) task and Morris water maze (MWM) 8 weeks after surgery...
January 11, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29302117/an-in-vitro-study-comparing-the-gme-handling-of-two-contemporary-oxygenators
#17
Carl J Gisnarian, Angela Hedman, Kenneth G Shann
Gaseous microemboli (GME) are a potential complication of cardiopulmonary bypass (CPB). Though it is difficult to prove that GME is the only major cause of neurological deficits, it may increase the chance of post-operative cognitive dysfunction if not removed. The objectives of this research were to compare LivaNova-Sorin Inspire (Inspire) oxygenator with a Medtronic arterial filter to the Medtronic Fusion (Fusion) oxygenator with and without a Medtronic arterial filter based on each system's ability to handle GME...
December 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/29279641/cerebral-air-embolism-secondary-to-lung-laceration
#18
Ashok Kumar Singh, Jayant Verma, Surendra Kumar
Cerebral air embolism is a rare clinical entity in day-to-day practice. The introduction of air into the venous or the arterial system can cause cerebral air embolism leading to severe neurological deficits. The common causes reported in the literature are iatrogenic; it can be caused by positive pressure maneuvers performed during cardiac resuscitation, lung biopsy, and the placement of venous catheters in the presence of a patent foramen ovale. We report a case of cerebral air embolism which has occurred secondary to lung laceration...
November 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29276216/malva-sylvestris-attenuates-cognitive-deficits-in-a-repetitive-mild-traumatic-brain-injury-rat-model-by-reducing-neuronal-degeneration-and-astrocytosis-in-the-hippocampus
#19
Hailin Qin, Jie Qin, Junmin Hu, He Huang, Lianting Ma
BACKGROUND The aim of our study was to evaluate the effect of Malva sylvestris (MS) on cognitive dysfunction in a repetitive mild traumatic brain injury (MTBI). MATERIAL AND METHODS MTBI was induced in all the study animals by hitting a metallic pendulum near the parietal-occipital area of the skull three times a day for ten days. Animals were treated with MS (250 mg/kg and 500 mg/kg) intragastrically per day for seven consecutive days. Cognitive function was estimated by the Morris water maze (MWM) method...
December 25, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29274721/cpg-odn-exerts-a-neuroprotective-effect-via-the-tlr9-pampk-signaling-pathway-by-activation-of-autophagy-in-a-neonatal-hie-rat-model
#20
Lan Ye, Zhanhui Feng, Desislava Doycheva, Jay Malaguit, Brandon Dixon, Ningbo Xu, John H Zhang, Jiping Tang
Hypoxic Ischemic Encephalopathy (HIE) is an injury caused to the brain due to prolonged lack of oxygen and blood supply which results in death or long-term disabilities. The main aim of this study was to investigate the role of Cytosine-phospho-guanine oligodeoxynucleotide (CpG-ODN) in autophagy after HIE. Ten-day old (P10) rat pups underwent right common carotid artery ligation followed by 2.5h of hypoxia as previously described by Rice-Vannucci. At 1h post HIE, rats were intranasally administered with recombinant CpG-ODN...
March 2018: Experimental Neurology
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