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Oxygen deficit in performance

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https://www.readbyqxmd.com/read/29362707/decrease-in-pulmonary-function-and-oxygenation-after-lung-resection
#1
Barbara Cristina Brocki, Elisabeth Westerdahl, Daniel Langer, Domingos S R Souza, Jan Jesper Andreasen
Respiratory deficits are common following curative intent lung cancer surgery and may reduce the patient's ability to be physically active. We evaluated the influence of surgery on pulmonary function, respiratory muscle strength and physical performance after lung resection. Pulmonary function, respiratory muscle strength (maximal inspiratory/expiratory pressure) and 6-min walk test (6MWT) were assessed pre-operatively, 2 weeks post-operatively and 6 months post-operatively in 80 patients (age 68±9 years)...
January 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29351000/age-effects-on-cerebral-oxygenation-and-behavior-in-children-with-sleep-disordered-breathing
#2
Knarik Tamanyan, Lisa M Walter, Aidan Weichard, Margot J Davey, Gillian M Nixon, Sarah N Biggs, Rosemary Sc Horne
RATIONALE: Childhood sleep disordered breathing ranges in severity from primary snoring to obstructive sleep apnea and is associated with behavioral and neurocognitive deficits. It remains unknown why children with primary snoring, who do not experience peripheral oxygen desaturation or sleep fragmentation, experience similar daytime deficits as those with obstructive sleep apnea or why effects are age dependent. OBJECTIVE: To examine cerebral tissue oxygenation and oxygen extraction as an explanation for daytime deficits in children with primary snoring...
January 19, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29346315/dietary-total-prenylflavonoids-from-the-fruits-of-psoralea-corylifolia-l-prevents-age-related-cognitive-deficits-and-down-regulates-alzheimer-s-markers-in-samp8-mice
#3
Zhi-Jing Chen, Yan-Fang Yang, Ying-Tao Zhang, Dong-Hui Yang
Alzheimer's disease (AD) is a serious threat for the aging society. In this study, we examined the preventive effect of the total prenylflavonoids (TPFB) prepared from the dried fruits of Psoralea corylifolia L., using an age-related AD mouse model SAMP8. We found that long-term dietary TPFB at 50 mg/kg·day significantly improved cognitive performance of the SAMP8 mice in Morris water maze tests, similar to 150 mg/kg·day of resveratrol, a popular neuro-protective compound. Furthermore, TPFB treatment showed significant improvements in various AD markers in SAMP8 brains, which were restored to near control levels of the normal mice, SAMR1...
January 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29327228/postoperative-intermittent-fasting-prevents-hippocampal-oxidative-stress-and-memory-deficits-in-a-rat-model-of-chronic-cerebral-hypoperfusion
#4
Yuan Hu, Miao Zhang, Yunyun Chen, Ying Yang, Jun-Jian Zhang
PURPOSE: Whether intermittent fasting (IF) treatment after stroke can prevent its long-term detrimental effects remains unknown. Here, we investigate the effects of postoperative IF on cognitive deficits and its underlying mechanisms in a permanent two-vessel occlusion (2VO) vascular dementia rat model. METHODS: Rats were subjected to either IF or ad libitum feeding 1 week after 2VO surgery. The cognition of rats was assessed using the novel object recognition (NOR) task and Morris water maze (MWM) 8 weeks after surgery...
January 11, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29302117/an-in-vitro-study-comparing-the-gme-handling-of-two-contemporary-oxygenators
#5
Carl J Gisnarian, Angela Hedman, Kenneth G Shann
Gaseous microemboli (GME) are a potential complication of cardiopulmonary bypass (CPB). Though it is difficult to prove that GME is the only major cause of neurological deficits, it may increase the chance of post-operative cognitive dysfunction if not removed. The objectives of this research were to compare LivaNova-Sorin Inspire (Inspire) oxygenator with a Medtronic arterial filter to the Medtronic Fusion (Fusion) oxygenator with and without a Medtronic arterial filter based on each system's ability to handle GME...
December 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/29279641/cerebral-air-embolism-secondary-to-lung-laceration
#6
Ashok Kumar Singh, Jayant Verma, Surendra Kumar
Cerebral air embolism is a rare clinical entity in day-to-day practice. The introduction of air into the venous or the arterial system can cause cerebral air embolism leading to severe neurological deficits. The common causes reported in the literature are iatrogenic; it can be caused by positive pressure maneuvers performed during cardiac resuscitation, lung biopsy, and the placement of venous catheters in the presence of a patent foramen ovale. We report a case of cerebral air embolism which has occurred secondary to lung laceration...
November 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29276216/malva-sylvestris-attenuates-cognitive-deficits-in-a-repetitive-mild-traumatic-brain-injury-rat-model-by-reducing-neuronal-degeneration-and-astrocytosis-in-the-hippocampus
#7
Hailin Qin, Jie Qin, Junmin Hu, He Huang, Lianting Ma
BACKGROUND The aim of our study was to evaluate the effect of Malva sylvestris (MS) on cognitive dysfunction in a repetitive mild traumatic brain injury (MTBI). MATERIAL AND METHODS MTBI was induced in all the study animals by hitting a metallic pendulum near the parietal-occipital area of the skull three times a day for ten days. Animals were treated with MS (250 mg/kg and 500 mg/kg) intragastrically per day for seven consecutive days. Cognitive function was estimated by the Morris water maze (MWM) method...
December 25, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29274721/cpg-odn-exerts-a-neuroprotective-effect-via-the-tlr9-pampk-signaling-pathway-by-activation-of-autophagy-in-a-neonatal-hie-rat-model
#8
Lan Ye, Zhanhui Feng, Desislava Doycheva, Jay Malaguit, Brandon Dixon, Ningbo Xu, John H Zhang, Jiping Tang
Hypoxic Ischemic Encephalopathy (HIE) is an injury caused to the brain due to prolonged lack of oxygen and blood supply which results in death or long-term disabilities. The main aim of this study was to investigate the role of Cytosine-phospho-guanine oligodeoxynucleotide (CpG-ODN) in autophagy after HIE. Ten-day old (P10) rat pups underwent right common carotid artery ligation followed by 2.5h of hypoxia as previously described by Rice-Vannucci. At 1h post HIE, rats were intranasally administered with recombinant CpG-ODN...
December 21, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29183693/title-glutathione-depletion-starting-point-of-brain-metabolic-stress-neuroinflammation-and-cognitive-impairment-in-rats
#9
Maria Elena González-Fraguela, Lisette Blanco, Caridad Ivette Fernández, Lourdes Lorigados, Teresa Serrano, Jessica López Fernández
Glutathione provides protection from oxidative stress-induced damage through the reduction of reactive oxygen species for the maintenance of oxidant homeostasis. Our purpose was to test the effects of depleting tissue GSH by buthionine sulfoximine on brain oxidative metabolism and cognitive performance in rats. Glutathione depletion induced a compensatory response on antioxidant enzymes and increase of cell damage indicators in all the examined cerebral areas at 24hours. The effect of GSH depletion on spatial memory recorded at 24h post-surgery showed significant differences between experimental groups for the escape latency to the platform and percentage of total swim distance spending in the target quadrant...
November 25, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29177514/transcriptome-analysis-of-pinus-halepensis-under-drought-stress-and-during-recovery
#10
Hagar Fox, Adi Doron-Faigenboim, Gilor Kelly, Ronny Bourstein, Ziv Attia, Jing Zhou, Yosef Moshe, Menachem Moshelion, Rakefet David-Schwartz
Forest trees use various strategies to cope with drought stress and these strategies involve complex molecular mechanisms. Pinus halepensis Miller (Aleppo pine) is found throughout the Mediterranean basin and is one of the most drought-tolerant pine species. In order to decipher the molecular mechanisms that P. halepensis uses to withstand drought, we performed large-scale physiological and transcriptome analyses. We selected a mature tree from a semi-arid area with suboptimal growth conditions for clonal propagation through cuttings...
November 21, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29159732/the-pgc-1%C3%AE-activator-zln005-ameliorates-ischemia-induced-neuronal-injury-in-vitro-and-in-vivo
#11
Yazhou Xu, John Alimamy Kabba, Wenchen Ruan, Yunjie Wang, Shunyi Zhao, Xiaoyue Song, Luyong Zhang, Jia Li, Tao Pang
Oxidative stress is a great challenge to neurons following cerebral ischemia. PGC-1α has been shown to act as a potent modulator of oxidative metabolism. In this study, the effects of ZLN005, a small molecule that activate PGC-1α, against oxygen-glucose deprivation (OGD)- or ischemia-induced neuronal injury in vitro and in vivo were investigated. Transient middle cerebral artery occlusion (tMCAO) was performed in rats and ZLN005 was administered intravenously at 2 h, 4 h, or 6 h after ischemia onset. Infarct volume and neurological deficit score were detected to evaluate the neuroprotective effects of ZLN005...
November 20, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29134467/diterpenoid-natural-compound-c4-crassin-exerts-cytostatic-effects-on-triple-negative-breast-cancer-cells-via-a-pathway-involving-reactive-oxygen-species
#12
Cathy E Richards, Sri H Vellanki, Yvonne E Smith, Ann M Hopkins
PURPOSE: Triple-negative breast cancers (TNBC) lack expression of three common cell surface receptors, i.e., estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2). Accordingly, TNBCs are associated with fewer treatment options and a relatively poor prognosis. Having screened a National Cancer Institute natural compound library, the purpose of this study was to investigate the bioactivity of compound C4 (Crassin) in TNBC cells. METHODS: Cell viability assays were performed in two TNBC cell lines, MDA-MB-231 and 4T1, following C4 treatment in the presence or absence of the antioxidant N-acetyl-L-cysteine (NAC)...
November 13, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29129679/pecularities-of-the-structure-of-glycogen-as-an-indicator-of-the-functional-state-of-mauthner-neurons-in-fish-perc%C3%B1-ottus-glehni-during-wintering
#13
Irina M Santalova, Rita Ya Gordon, Irina B Mikheeva, Sergei S Khutsian, Eugene I Maevsky
Mauthner neurons (MN)*, specific multifunctional neurons of fish, are a unique object for investigating the adaptive potentialities of the cell. The goal of the work was to study the structure of MN of fish Percсottus glehni during wintering under the conditions of hypothermia and deficit of oxygen and energy substrates. It was shown using a light microscope that the volume of the somatic moiety of neurons changes slightly at the beginning of wintering and is significantly reduced by the termination of wintering...
November 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29119418/low-level-laser-therapy-improves-the-vo2-kinetics-in-competitive-cyclists
#14
Fábio J Lanferdini, Renata L Krüger, Bruno M Baroni, Caetano Lazzari, Pedro Figueiredo, Alvaro Reischak-Oliveira, Marco A Vaz
Some evidence supports that low-level laser therapy (LLLT) reduces neuromuscular fatigue, so incrementing sports performance. A previous randomized controlled trial of our group showed increased exercise tolerance in male competitive cyclists treated with three different LLLT doses (3, 6, and 9 J/diode; or 135, 270, and 405 J/thigh) before time-to-exhaustion cycling tests. Now, the present study was designed to evaluate the effects of these LLLT doses on the VO2 kinetics of athletes during cycling tests. Twenty male competitive cyclists (29 years) participated in a crossover, randomized, double-blind, and placebo-controlled trial...
November 9, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29080695/improvement-in-cerebral-ischemia-reperfusion-injury-through-the-tlr4-nf-%C3%AE%C2%BAb-pathway-after-kudiezi-injection-in-rats
#15
Xuemei Liu, Xinyang Zhang, Fengli Wang, Xiao Liang, Zixiu Zeng, Jiayi Zhao, Hong Zheng, Xiangning Jiang, Yunling Zhang
AIM: Kudiezi injection (KDZ) can improve the clinical outcomes of patients with stroke, but the mechanisms remain unclear. This study aimed to investigate whether KDZ could modulate the nuclear factor kappa B (NF-κB) pathways in rat models of transient middle cerebral artery occlusion (tMCAO). MATERIALS AND METHODS: Male Sprague-Dawley rats were subjected to tMCAO and randomized to Sham (sham-operated), tMCAO (tMCAO+0.9% saline), and KDZ (tMCAO+7.2mL/kg KDZ) groups...
October 28, 2017: Life Sciences
https://www.readbyqxmd.com/read/29067352/combined-mnemonic-strategy-training-and-high-definition-transcranial-direct-current-stimulation-for-memory-deficits-in-mild-cognitive-impairment
#16
Benjamin M Hampstead, Krishnankutty Sathian, Marom Bikson, Anthony Y Stringer
INTRODUCTION: Memory deficits characterize Alzheimer's dementia and the clinical precursor stage known as mild cognitive impairment. Nonpharmacologic interventions hold promise for enhancing functioning in these patients, potentially delaying functional impairment that denotes transition to dementia. Previous findings revealed that mnemonic strategy training (MST) enhances long-term retention of trained stimuli and is accompanied by increased blood oxygen level-dependent signal in the lateral frontal and parietal cortices as well as in the hippocampus...
September 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29066977/anaerobic-contribution-determined-in-swimming-distances-relation-with-performance
#17
Eduardo Z Campos, Carlos A Kalva-Filho, Ronaldo B Gobbi, Ricardo A Barbieri, Nayara P Almeida, Marcelo Papoti
Total anaerobic contribution (TAn) can be assessed by accumulated oxygen deficit, and through sum of glycolytic and phosphagen contribution which enable the evaluation of TAn without influences on mechanical parameters. However, little is known about the difference of TAn within swimming distances. Therefore, the objectives of the present study were to determine and compare the TAn in different performances using the backward extrapolation technique and amount of lactate accumulated during exercise, and relate it with swimming performance...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29042856/the-utility-of-a-computerized-algorithm-based-on-a-multi-domain-profile-of-measures-for-the-diagnosis-of-attention-deficit-hyperactivity-disorder
#18
Alessandro Crippa, Christian Salvatore, Erika Molteni, Maddalena Mauri, Antonio Salandi, Sara Trabattoni, Carlo Agostoni, Massimo Molteni, Maria Nobile, Isabella Castiglioni
The current gold standard for diagnosis of attention deficit/hyperactivity disorder (ADHD) includes subjective measures, such as clinical interview, observation, and rating scales. The significant heterogeneity of ADHD symptoms represents a challenge for this assessment and could prevent an accurate diagnosis. The aim of this work was to investigate the ability of a multi-domain profile of measures, including blood fatty acid (FA) profiles, neuropsychological measures, and functional measures from near-infrared spectroscopy (fNIRS), to correctly recognize school-aged children with ADHD...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29036480/treatment-of-obstructive-sleep-apnoea-hypopnea-syndrome-by-mandible-advanced-device-reduced-neuron-apoptosis-in-frontal-cortex-of-rabbits
#19
Hai-Yan Lu, Wen Wang, Zheng Zhou, Chun-Yan Liu, Ye Liu, Wei Xiao, Fu-Sheng Dong, Jie Wang
Objective: To investigate effects of mandible advanced device (MAD) therapy for obstructive sleep apnoea-hypopnea syndrome (OSAHS) on the neuron apoptosis and acetylcholine esterase activity in frontal cortex. Materials and methods: Thirty male New Zealand white rabbits were randomly divided into three groups (n = 10 in each group): group OSAHS, group MAD, and control group. Hydrophilic polyacrylamide gel was injected into soft palate of the animals to induce OSAHS in group OSAHS and group MAD...
September 23, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29018380/college-binge-drinking-associated-with-decreased-frontal-activation-to-negative-emotional-distractors-during-inhibitory-control
#20
Julia E Cohen-Gilbert, Lisa D Nickerson, Jennifer T Sneider, Emily N Oot, Anna M Seraikas, Michael L Rohan, Marisa M Silveri
The transition to college is associated with an increase in heavy episodic alcohol use, or binge drinking, during a time when the prefrontal cortex and prefrontal-limbic circuitry continue to mature. Traits associated with this immaturity, including impulsivity in emotional contexts, may contribute to risky and heavy episodic alcohol consumption. The current study used blood oxygen level dependent (BOLD) multiband functional magnetic resonance imaging (fMRI) to assess brain activation during a task that required participants to ignore background images with positive, negative, or neutral emotional valence while performing an inhibitory control task (Go-NoGo)...
2017: Frontiers in Psychology
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