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https://www.readbyqxmd.com/read/27933677/the-effect-of-slow-paced-breathing-on-stress-management-in-adolescents-with-intellectual-disability
#1
S Laborde, M S Allen, N Göhring, F Dosseville
BACKGROUND: Intellectual disabilities often create a state of chronic stress for both the person concerned and their significant others (family, caregivers). The development of stress management methods is therefore important for the reduction of stress in persons with intellectual disability. The aim of this experiment was to investigate the effect of slow-paced breathing on stress symptoms experienced by adolescents with intellectual disabilities during a cognitive task under time pressure...
December 9, 2016: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/27933636/primary-headaches-in-an-elderly-population-seeking-medical-care-for-cognitive-decline
#2
Michele Feleppa, Silvia Fucci, Marcelo E Bigal
OBJECTIVES: To assess the prevalence of specific headache disorders in a population older than 65 years seeking consultation due to memory problems or cognitive impairment. METHODS: We verified the occurrence of headache symptoms and the impact of headaches on daily life. Headaches were classified as per the International Classification of Headache Disorders, 2nd edition (ICHD-2). All patients were screened with the Mini-Mental State Examination (MMSE), followed by the Selective Reminding Test and neuroimaging...
December 9, 2016: Headache
https://www.readbyqxmd.com/read/27933471/factors-associated-with-medication-non-adherence-in-patients-with-end-stage-liver-disease
#3
Selena Z Kuo, Marta Haftek, Jennifer C Lai
BACKGROUND: Low medication adherence is known to contribute to worse health outcomes in the general population. AIM: We aimed to evaluate the medication regimen and determine the adherence levels among patients with end-stage liver disease. METHODS: We measured adherence in patients awaiting liver transplantation at a single center using the 8-item Morisky Medication Adherence Scale (MMAS-8), with a score <8 classified as low adherence...
December 8, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27933206/improving-inflammatory-arthritis-management-through-tighter-monitoring-of-patients-and-the-use-of-innovative-electronic-tools
#4
REVIEW
Piet van Riel, Rieke Alten, Bernard Combe, Diana Abdulganieva, Paola Bousquet, Molly Courtenay, Cinzia Curiale, Antonio Gómez-Centeno, Glenn Haugeberg, Burkhard Leeb, Kari Puolakka, Angelo Ravelli, Bernhard Rintelen, Piercarlo Sarzi-Puttini
Treating to target by monitoring disease activity and adjusting therapy to attain remission or low disease activity has been shown to lead to improved outcomes in chronic rheumatic diseases such as rheumatoid arthritis and spondyloarthritis. Patient-reported outcomes, used in conjunction with clinical measures, add an important perspective of disease activity as perceived by the patient. Several validated PROs are available for inflammatory arthritis, and advances in electronic patient monitoring tools are helping patients with chronic diseases to self-monitor and assess their symptoms and health...
2016: RMD Open
https://www.readbyqxmd.com/read/27933133/pre-operative-clinical-and-instrumental-factors-as-antireflux-surgery-outcome-predictors
#5
REVIEW
Salvatore Tolone, Giorgia Gualtieri, Edoardo Savarino, Marzio Frazzoni, Nicola de Bortoli, Manuele Furnari, Giuseppina Casalino, Simona Parisi, Vincenzo Savarino, Ludovico Docimo
Gastroesophageal reflux disease (GERD) is nowadays a highly prevalent, chronic condition, with 10% to 30% of Western populations affected by weekly symptoms. Many patients with mild reflux symptoms are treated adequately with lifestyle modifications, dietary changes, and low-dose proton pump inhibitors (PPIs). For those with refractory GERD poorly controlled with daily PPIs, numerous treatment options exist. Fundoplication is currently the most commonly performed antireflux operation for management of GERD...
November 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27932984/curcumin-suppressed-activation-of-dendritic-cells-via-jak-stat-socs-signal-in-mice-with-experimental-colitis
#6
Hai-Mei Zhao, Rong Xu, Xiao-Ying Huang, Shao-Min Cheng, Min-Fang Huang, Hai-Yang Yue, Xin Wang, Yong Zou, Ai-Ping Lu, Duan-Yong Liu
Dendritic cells (DCs) play a pivotal role as initiators in the pathogenesis of inflammatory bowel disease and are regulated by the JAK/STAT/SOCS signaling pathway. As a potent anti-inflammatory compound, curcumin represents a viable treatment alternative or adjunctive therapy in the management of chronic inflammatory bowel disease (IBD). The mechanism of curcumin treated IBD on DCs is not completely understood. In the present study, we explored the mechanism of curcumin treated experimental colitis by observing activation of DCs via JAK/STAT/SOCS signaling pathway in colitis mice...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27932895/are-patients-and-doctors-accounts-of-the-first-specialist-consultation-for-chronic-back-pain-in-agreement
#7
Kathy B White, John Lee, Amanda C de C Williams
INTRODUCTION: The first consultation at a specialist pain clinic is potentially a pivotal event in a patient's pain history, affecting treatment adherence and engagement with longer term self-management. What doctors communicate to patients about their chronic pain and how patients interpret doctors' messages and explanations in pain consultations are under-investigated, particularly in specialist care. Yet, patients value personalized information about their pain problem. PATIENTS AND METHODS: Sixteen patients in their first specialist pain clinic consultation and the doctors they consulted were interviewed shortly after the consultation...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27932436/multifactorial-pathological-hip-subluxation-in-neurofibromatosis-type-1-nf1-due-to-intra-articular-plexiform-neurofibroma-lumbar-radiculopathy-and-neurofibromatous-polyneuropathy
#8
Waqar Waheed, Diego F Diego F Lemos, Nelms Nathaniel Nelms, Rup Tandan
Neurofibromatosis type-1 (NF1) is a multisystem disorder with very rare descriptions of hip instability. We report a case of a 37-year-old man with known NF1 and childhood-onset of left foot drop, who developed persistent left hip pain following a minor trauma. Physical examination revealed left-sided mild foot drop, hip abductor weakness, bilateral sensory loss in feet and an antalgic gait. Work-up revealed anterolateral subluxation of the left femoral head along with left hip plexiform neurofibroma (PN), dysplastic and degenerative changes, neurofibromatous neuropathy and chronic left L5 radiculopathy...
December 8, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27932296/low-density-lipoproteins-amplify-cytokine-signaling-in-chronic-lymphocytic-leukemia-cells
#9
Lindsay McCaw, Yonghong Shi, Guizhi Wang, You-Jun Li, David E Spaner
Recent studies suggest there is a high incidence of elevated low-density lipoprotein (LDL) levels in Chronic Lymphocytic Leukemia (CLL) patients and a survival benefit from cholesterol-lowering statin drugs. The mechanisms of these observations and the kinds of patients they apply to are unclear. Using an in vitro model of the pseudofollicles where CLL cells originate, LDLs were found to increase plasma membrane cholesterol, signaling molecules such as tyrosine-phosphorylated STAT3, and activated CLL cell numbers...
November 30, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27932148/low-dose-spinal-block-with-continuous-epidural-infusion-for-renal-transplantation-in-a-patient-with-alport-syndrome-a-case-report
#10
F Gobbi, G Sales, P Bretto, P P Donadio, L Brazzi
OBJECTIVE: We aim to describe management of a patient receiving renal transplantation for chronic renal failure due to Alport syndrome with low dose of intrathecal bupivacaine and continuous epidural infusion of local anesthetic. CASE REPORT: A 38-years-old man with chronic renal failure secondary to Alport syndrome underwent kidney transplantation. Because of a high risk of respiratory and cardiovascular complications related to the patient's baseline lung disease and abnormalities in heart conduction, we selected combined spinal-epidural anesthesia...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27932054/changes-in-physical-activity-sedentary-time-and-risk-of-falling-the-women-s-health-initiative-observational-study
#11
Jennifer W Bea, Cynthia A Thomson, Robert B Wallace, Chunyuan Wu, Rebecca A Seguin, Scott B Going, Andrea LaCroix, Charles Eaton, Judith K Ockene, Michael J LaMonte, Rebecca Jackson, W Jerry Mysiw, Jean Wactawski-Wende
Falling significantly affects quality of life, morbidity, and mortality among older adults. We sought to evaluate the prospective association between sedentary time, physical activity, and falling among post-menopausal women aged 50-79 y recruited to the Women's Health Initiative Observational Study between 1993 and 1998 from 40 clinical centers across the United States. Baseline (B) and change in each of the following were evaluated at year 3 (Y3) and year 6 (Y6; baseline n=93,676; Y3 n=76,598; Y6 n=75,428): recreational physical activity (MET-h/wk), sitting, sleeping (min/d), and lean body mass by dual energy X-ray absorptiometry (subset N=6,475)...
December 5, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27932014/tackling-the-burden-of-the-hepatitis-c-virus-in-the-uk-characterizing-and-assessing-the-clinical-and-economic-consequences
#12
T Ward, J Gordon, H Bennett, S Webster, D Sugrue, B Jones, M Brenner, P McEwan
OBJECTIVES: The hepatitis C virus (HCV) remains a significant public health issue. This study aimed to quantify the clinical and economic burden of chronic hepatitis C in the UK, stratified by disease severity, age and awareness of infection, with concurrent assessment of the impact of implementing a treatment prioritization approach. STUDY DESIGN AND METHODS: A previously published back projection, natural history and cost-effectiveness HCV model was adapted to a UK setting to estimate the disease burden of chronic hepatitis C and end-stage liver disease (ESLD) between 1980 and 2035...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931964/imaging-in-paediatric-rheumatology-is-it-time-for-imaging
#13
REVIEW
Paz Collado, Clara Malattia
Juvenile idiopathic arthritis (JIA) is a heterogeneous group of arthritides characterized by chronic synovial inflammation that can lead to structural damage. The main objective of JIA therapies is to induce disease control to avoid disability in childhood. The advances in therapeutic effectiveness have created a need to search for imaging tools that describe more precisely disease activity in children with JIA. Musculoskeletal ultrasound and magnetic resonance imaging have demonstrated to be more sensitive than clinical examination in early detection of synovitis...
August 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27931749/-hereditary-epidermolysis-bullosa-french-national-guidelines-pnds-for-diagnosis-and-treatment
#14
C Chiaverini, E Bourrat, J Mazereeuw-Hautier, S Hadj-Rabia, C Bodemer, J-P Lacour
Hereditary epidermolysis bullosa (EB) is a heterogeneous group of rare genetic diseases characterized by fragile skin and/or mucous membrane, and it may be either local or generalized. It is caused by mutations in genes encoding different proteins involved mainly in the structure and function of the dermal-epidermal junction. Nineteen genes have so far been identified. They are classified by level of skin cleavage (from top to bottom) into four groups: EB simplex, junctional EB, dystrophic EB and Kindler syndrome...
December 5, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27931566/barriers-to-organ-transplantation-in-the-algerian-health-system-from-the-perspective-of-health-professionals-a-qualitative-approach
#15
N Laidouni, D Gil-González, S Latorre-Arteaga
BACKGROUND: Organ transplantation is often the only treatment for end-stage organ failure and is considered to be a cost-effective intervention with high impact on the health and quality of life of patients with chronic illnesses. Algeria has low rates of organ donation and transplantation, and health system coverage is not sufficient for the large number of patients awaiting this type of treatment. Physicians' perspectives about the health system are essential to understanding the obstacles present in the development of transplant services...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931505/phase-iii-clinical-trial-assessing-safety-and-efficacy-of-umbilical-cord-blood-mononuclear-cell-transplant-therapy-of-chronic-complete-spinal-cord-injury
#16
Hui Zhu, Waisang Poon, Yansheng Liu, Gilberto Ka-Kit Leung, Yatwa Wong, Yaping Feng, Stephanie C P Ng, Kam Sze Tsang, David T F Sun, David K Yeung, Caihong Shen, Fang Niu, Zhexi Xu, Pengju Tan, Shaofeng Tang, Hongkun Gao, Yun Cha, Kwok-Fai So, Robert Fleischaker, Dongming Sun, John Chen, Jan Lai, Wendy Cheng, Wise Young
Umbilical cord blood-derived mononuclear cell (UCB-MNC) transplants improve recovery in animal spinal cord injury (SCI) models. We transplanted UCB-MNCs into 28 patients with chronic complete SCI in Hong Kong (HK) and Kunming (KM). Stemcyte Inc. donated UCB-MNCs isolated from human leukocyte antigen (HLA 4:6)-matched UCB units. In HK, four patients received four 4-l injections (1.6 million cells) into dorsal entry zones above and below the injury site, and another four received 8-l injections (3.2 million cells)...
November 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27931255/wealth-and-cardiovascular-health-a-cross-sectional-study-of-wealth-related-inequalities-in-the-awareness-treatment-and-control-of-hypertension-in-high-middle-and-low-income-countries
#17
Benjamin Palafox, Martin McKee, Dina Balabanova, Khalid F AlHabib, Alvaro Jr Avezum, Ahmad Bahonar, Noorhassim Ismail, Jephat Chifamba, Clara K Chow, Daniel J Corsi, Gilles R Dagenais, Rafael Diaz, Rajeev Gupta, Romaina Iqbal, Manmeet Kaur, Rasha Khatib, Annamarie Kruger, Iolanthe Marike Kruger, Fernando Lanas, Patricio Lopez-Jaramillo, Fu Minfan, Viswanathan Mohan, Prem K Mony, Aytekin Oguz, Lia M Palileo-Villanueva, Pablo Perel, Paul Poirier, Sumathy Rangarajan, Lei Rensheng, Annika Rosengren, Biju Soman, David Stuckler, S V Subramanian, Koon Teo, Lungiswa P Tsolekile, Andreas Wielgosz, Peng Yaguang, Karen Yeates, Mo Yongzhen, Khalid Yusoff, Rita Yusuf, Afzalhussein Yusufali, Katarzyna Zatońska, Salim Yusuf
BACKGROUND: Effective policies to control hypertension require an understanding of its distribution in the population and the barriers people face along the pathway from detection through to treatment and control. One key factor is household wealth, which may enable or limit a household's ability to access health care services and adequately control such a chronic condition. This study aims to describe the scale and patterns of wealth-related inequalities in the awareness, treatment and control of hypertension in 21 countries using baseline data from the Prospective Urban and Rural Epidemiology study...
December 8, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27931138/medicinal-plants-and-natural-products-in-amelioration-of-arsenic-toxicity-a-short-review
#18
Sanijb Bhattacharya
CONTEXT: Chronic arsenic toxicity (arsenicosis) is considered a serious public health menace worldwide, as there is no specific, safe, and efficacious therapeutic management of arsenicosis. OBJECTIVES: To collate the studies on medicinal plants and natural products with arsenic toxicity ameliorative effect, active pre-clinically and/or clinically. METHODS: Literature survey was carried out by using Google, Scholar Google and Pub-Med. Only the scientific journal articles found on the internet for last two decades were considered...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27931127/prebiotics-and-synbiotics-in-ulcerative-colitis
#19
Axel Laurell, Klas Sjöberg
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with unclear pathogenesis. A dysbiotic intestinal microbiota is regarded as a key component in the disease process and there has been significant interest in developing new treatments which target the microbiota. AIM: To give an overview of the studies to date investigating prebiotics and synbiotics for the treatment of UC. METHODS: A literature search of PubMed and related search engines was carried out using the terms "ulcerative colitis" in combination with "prebiotic", "synbiotic" or "dietary fibre"...
December 8, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27931029/selective-necrosectomy-for-infected-pancreatic-necrosis
#20
Ola Ahmed, Claire L Donohoe, Daragh B Murphy, Brian J Marsh, John Conneely, Gerry P McEntee
BACKGROUND: Until recently, a diagnosis of infected pancreatic necrosis (IPN) warranted necrosectomy, which was associated with high morbidity and mortality rates greater than 20%. Preoperative percutaneous drainage delayed the need for necrosectomy with improved outcomes. METHODS: In 2008, this institution changed its approach to the management of such cases opting instead for percutaneous drainage with selective deferred necrosectomy. A total of 38 consecutive patients with IPN from January 2008 to December 2014 were included...
December 9, 2016: Digestive Surgery
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