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https://www.readbyqxmd.com/read/28934140/applications-of-pna-based-artificial-restriction-dna-cutters
#1
REVIEW
Narumi Shigi, Jun Sumaoka, Makoto Komiyama
More than ten years ago, artificial restriction DNA cutters were developed by combining two pseudo-complementary peptide nucleic acid (pcPNA) strands with either Ce(IV)/EDTA or S1 nuclease. They have remarkably high site-specificity and can cut only one predetermined site in the human genome. In this article, recent progress of these man-made tools have been reviewed. By cutting the human genome site-selectively, desired fragments can be clipped from either the termini of chromosomes (telomeres) or from the middle of genome...
September 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28934132/surface-modification-of-polymer-substrates-for-biomedical-applications
#2
REVIEW
Oldřich Neděla, Petr Slepička, Václav Švorčík
While polymers are widely utilized materials in the biomedical industry, they are rarely used in an unmodified state. Some kind of a surface treatment is often necessary to achieve properties suitable for specific applications. There are multiple methods of surface treatment, each with their own pros and cons, such as plasma and laser treatment, UV lamp modification, etching, grafting, metallization, ion sputtering and others. An appropriate treatment can change the physico-chemical properties of the surface of a polymer in a way that makes it attractive for a variety of biological compounds, or, on the contrary, makes the polymer exhibit antibacterial or cytotoxic properties, thus making the polymer usable in a variety of biomedical applications...
September 21, 2017: Materials
https://www.readbyqxmd.com/read/28933844/mind-the-metal-a-fragment-library-derived-zinc-impurity-binds-the-e2-ubiquitin-conjugating-enzyme-ube2t-and-induces-structural-rearrangements
#3
Francesca E Morreale, Andrea Testa, Viduth K Chaugule, Alessio Bortoluzzi, Alessio Ciulli, Helen Walden
Efforts to develop inhibitors, activators and effectors of biological reactions using small molecule libraries are often hampered by interference compounds, artifacts and false positives that permeate the pool of initial hits. Here we report the discovery of a promising initial hit compound targeting the Fanconi anemia ubiquitin-conjugating enzyme Ube2T and describe its biophysical and biochemical characterization. Analysis of the co-crystal structure led to the identification of a contaminating zinc ion as solely responsible for the observed effects...
September 21, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28933831/one-dimensional-zinc-based-coordination-polymer-as-a-higher-capacity-anode-material-for-lithium-ion-batteries
#4
Yidan Song, Lili Yu, Yuanrui Gao, Changdong Shi, Meiling Cheng, Xianmei Wang, Hong-Jiang Liu, Qi Liu
A zinc-based one-dimensional (1D) coordination polymer ([Zn(H2mpca)2(tfbdc)(H2O)], Zn-ODCP) has been synthesized and characterized by spectroscopic and physicochemical methods, single-crystal X-ray diffraction, and thermogravimetric analysis (H2mpca = 3-methyl-1H-pyrazole-4-carboxylic acid; H2tfbdc = 2,3,5,6-tetrafluoroterephthalic acid). Zn-ODCP shows blue luminescence in the solid state. When Zn-ODCP acts as an anode material for lithium ion batteries, it exhibits a good cyclic stability and a higher reversible capacity of 300 mAh g(-1) at 50 mA g(-1) after 50 cycles...
September 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28933740/synthesis-characterization-and-in-vitro-evaluation-of-a-novel-glycol-chitosan-edta-conjugate-to-inhibit-aminopeptidase-mediated-degradation-of-thymopoietin-oligopeptides
#5
Jiao Feng, Yan Chen, Feng Li, Lili Cui, Nianqiu Shi, Wei Kong, Yong Zhang
In this study, a novel conjugate consisting of glycol chitosan (GCS) and ethylene diamine tetraacetic acid (EDTA) was synthesized and characterized in terms of conjugation and heavy metal ion chelating capacity. Moreover, its potential application as a metalloenzyme inhibitor was evaluated with three thymopoietin oligopeptides in the presence of leucine aminopeptidase. The results from FTIR and NMR spectra revealed that the covalent attachment of EDTA to GCS was achieved by the formation of amide bonds between the carboxylic acid group of EDTA and amino groups of GCS...
July 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28933729/structure-and-catalysis-of-fe-iii-and-cu-ii-microperoxidase-11-interacting-with-the-positively-charged-interfaces-of-lipids
#6
Tatiana Prieto, Vinicius Santana, Adrianne M M Britto, Juliana C Araujo-Chaves, Otaciro R Nascimento, Iseli L Nantes-Cardoso
Numerous applications have been described for microperoxidases (MPs) such as in photoreceptors, sensing, drugs, and hydrogen evolution. The last application was obtained by replacing Fe(III), the native central metal, by cobalt ion and inspired part of the present study. Here, the Fe(III) of MP-11 was replaced by Cu(II) that is also a stable redox state in aerated medium, and the structure and activity of both MPs were modulated by the interaction with the positively charged interfaces of lipids. Comparative spectroscopic characterization of Fe(III) and Cu(II)MP-11 in the studied media demonstrated the presence of high and low spin species with axial distortion...
July 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28933540/metal-complexes-with-a-hexadentate-macrocyclic-diamine-tetracarbene-ligand
#7
Taotao Lu, Chu-Fan Yang, Li-Yi Zhang, Fan Fei, Xue-Tai Chen, Zi-Ling Xue
A hexadentate macrocyclic N-heterocyclic carbene (NHC) ligand precursor (H4L)(PF6)4 containing four benzimidazolium and two secondary amine groups, has been synthesized and characterized. Coordination chemistry of this new macrocyclic diamine-tetracarbene ligand has been studied by the synthesis of its Ag(I), Au(I), Ni(II), and Pd(II) complexes. Reactions of (H4L)(PF6)4 with different equiv of Ag2O result in Ag(I) complexes [Ag(H2L)](PF6)3 (1) and [Ag2(H2L)](PF6)4 (2). A mononuclear Au(I) complex [Au(H2L)](PF6)3 (3) and a trinuclear Au(I) complex [Au3(H2L)(Cl)2](PF6) (4) are obtained by transmetalation of 1 and 2 with AuCl(SMe2), respectively...
September 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28933538/bulky-%C3%AE-diketones-enabling-new-lewis-acidic-ligand-platforms
#8
Eser S Akturk, Steven J Scappaticci, Rachel N Seals, Michael P Marshak
The synthesis of a sterically encumbered β-diketone ligand ((Ar)acac) substituted with 2,6-(2,4,6-Me3C6H2)2C6H3 is described. Coordination complexes of the type M((Ar)acac)2Cl(solv) (M = Ti, V, Cr; solv = THF, CH3CN) were prepared by the reaction of (Ar)acac with MCl3 (M = V, Cr) or with TiCl4 to generate Ti((Ar)acac)2Cl2, followed by reduction. These complexes show a trend of alternating the cis/trans geometric preference with increasing d(n) electron count (n = 0, 1, 2, 3), which is rationalized in part by the unusual ability of β-diketonates to behave as either a weak π donor or a π acceptor in the cis and trans geometries, respectively...
September 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28933528/inert-layered-silicate-improves-the-electrochemical-responses-of-a-metal-complex-polymer
#9
Miharu Eguchi, Masako Momotake, Fumie Inoue, Takayoshi Oshima, Kazuhiko Maeda, Masayoshi Higuchi
A chemically inert, insulating layered silicate (saponite; SP) and an iron(II)-based metallo-supramolecular complex polymer (polyFe) were combined via electrostatic attraction to improve the electrochromic properties of polyFe. Structural characterization indicated that polyFe was intercalated into the SP nanosheets. Interestingly, the redox potential of polyFe was lowered by combining it with SP, and the current was measurable despite the insulating nature of SP. X-ray photoelectron spectroscopy showed that the decrease of the redox potential observed in the SP-polyFe hybrid was caused by electrostatic neutralization of the Fe cation in polyFe by the negative charge on SP...
September 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28933481/bowl-shaped-deformation-in-a-planar-aromatic-polycycle-upon-reduction-li-and-na-separated-dianions-of-the-aromatic-polycycle-5-6-11-12-di-o-phenylene-tetracene
#10
T Wombacher, R Goddard, C W Lehmann, J J Schneider
Herein we report the synthesis and crystal structures of three light alkali metal salts of the dianion of the polycyclic aromatic hydrocarbon 5,6:11,12-di-o-phenylenetetracene (LDOPT). The compounds are obtained by reaction of LDOPT with an excess of lithium or sodium metal in different O-donor solvents (DME, diglyme) and crystallize as naked, solvated-cation separated dianions exhibiting no interaction between the alkali metal ion and the aromatic π-system of LDOPT. Depending on the aprotic etheral solvent and the hardness of the alkaline metal agent a significant structural perturbation of the conjugated carbon framework of LDOPT is observed resulting in a bowl shaped curvature of the anionic π-perimeter, in contrast to its fully planar neutral state...
September 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28933279/zinc-transporter-protein-tzn-1-may-also-play-a-role-in-conidiation-pathway-of-neurospora-crassa-an-insight-using-proteogenomic-approachusing-proteogenomic-approach
#11
Divya Rupa Venkata Pandala, Jogeswar Gadi, Kiranmayi Patnala
Zinc transporter (tzn-1) of Neurospora crassa plays a crucial role in conidiation pathway, as its removal results in aconidiation which was reported in our earlier studies. Present study depicts the role of tzn-1 in conidiation process, by comparing knockout (KO) mutants zinc transporter KO (Δtzn-1) and aconidiating gene KO (Δacon-3) with wild oak ridge (OR) 74 'A' strain by 'Proteo-genomic' approach. Firstly, nine commonly overexpressed protein spots from the two sets (Δtzn-1 to wild and Δacon-3 to wild) were analyzed by combining 2-Dimensional gel electrophoresis (2DE) with Matrix Associated Laser Desorption/Ionization mass spectrometry -Peptide Mass Fingerprint (MALDI-PMF)...
September 19, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28932505/the-features-of-morphological-changes-in-the-urinary-bladder-under-combined-effect-of-heavy-metal-salts
#12
Anatolii Romaniuk, Vladyslav Sikora, Mykola Lyndin, Vladyslav Smiyanov, Volodymyr Sikora, Yulia Lyndina, Artem Piddubnyi, Nataliya Gyryavenko, Anna Korobchanska
PURPOSE: This study is aimed to the investigation of the features of morphological changes in the urinary bladder of mature rats. RESULTS: Received results shown that the experimental group of rats that had the intake of heavy metal salts (HMS) mixture during 30 and 90 days were observed histological and immunohistochemical changes in all structures of the urinary bladder. Depending on the period of influence of heavy metal ions on the wall of the organ, the pathological changes developed in cellular layers of the wall can lead to degenerative and later to atrophic and sclerotic changes...
June 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28932404/crystalexplorer-model-energies-and-energy-frameworks-extension-to-metal-coordination-compounds-organic-salts-solvates-and-open-shell-systems
#13
Campbell F Mackenzie, Peter R Spackman, Dylan Jayatilaka, Mark A Spackman
The application domain of accurate and efficient CE-B3LYP and CE-HF model energies for intermolecular interactions in molecular crystals is extended by calibration against density functional results for 1794 molecule/ion pairs extracted from 171 crystal structures. The mean absolute deviation of CE-B3LYP model energies from DFT values is a modest 2.4 kJ mol(-1) for pairwise energies that span a range of 3.75 MJ mol(-1). The new sets of scale factors determined by fitting to counterpoise-corrected DFT calculations result in minimal changes from previous energy values...
September 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/28932199/bacillus-a-biological-tool-for-crop-improvement-through-bio-molecular-changes-in-adverse-environments
#14
REVIEW
Ramalingam Radhakrishnan, Abeer Hashem, Elsayed F Abd Allah
Crop productivity is affected by environmental and genetic factors. Microbes that are beneficial to plants are used to enhance the crop yield and are alternatives to chemical fertilizers and pesticides. Pseudomonas and Bacillus species are the predominant plant growth-promoting bacteria. The spore-forming ability of Bacillus is distinguished from that of Pseudomonas. Members of this genus also survive for a long time under unfavorable environmental conditions. Bacillus spp. secrete several metabolites that trigger plant growth and prevent pathogen infection...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28931874/probing-nanoscale-damage-gradients-in-ion-irradiated-metals-using-spherical-nanoindentation
#15
Siddhartha Pathak, Surya R Kalidindi, Jordan S Weaver, Yongqiang Wang, Russell P Doerner, Nathan A Mara
We discuss and demonstrate the application of recently developed spherical nanoindentation stress-strain protocols in characterizing the mechanical behavior of tungsten polycrystalline samples with ion-irradiated surfaces. It is demonstrated that a simple variation of the indenter size (radius) can provide valuable insights into heterogeneous characteristics of the radiation-induced-damage zone. We have also studied the effect of irradiation for the different grain orientations in the same sample.
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931866/ion-channel-aligned-gas-blocking-membrane-for-lithium-air-batteries
#16
Wonsung Choi, Mokwon Kim, Jung Ock Park, Joon-Hee Kim, Kyunghwan Choi, Yong Su Kim, Tae Young Kim, Ken Ogata, Dongmin Im, Seok-Gwang Doo, Yunil Hwang
Lithium-metal-based batteries, owing to the extremely high specific energy, have been attracting intense interests as post-Li-ion batteries. However, their main drawback is that consumption/de-activation of lithium metal can be accelerated when O2 or S used in the cathode crosses over to the metal, reducing the lifetime of the batteries. In use of ceramic solid state electrolyte (SSE) separator, despite the capability of gas blocking, thick and heavy plates (~0.3 mm) are necessitated to compensate its mechanical fragility, which ruin the high specific energy of the batteries...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931352/relationship-between-pelvic-incidence-angle-and-blood-concentration-of-chromium-and-cobalt-ions-after-metal-on-metal-hip-replacement-a-brief-report
#17
K Pernaa, M Saltychev, K Mäkelä
BACKGROUND AND AIMS: The wear of metal-on-metal hip implants may increase chromium or cobalt ion blood level. This phenomenon may depend among other things on the particularity of spinopelvic anatomy. The effect of pelvic incidence angle on the wear of metal-on-metal hip implants is not known. The objective of the study was to investigate whether such effect does exist. MATERIAL AND METHODS: The pelvic incidence and inclination of acetabular component angles of 89 patients after unilateral metal-on-metal hip replacement were compared with blood level of chromium and cobalt ions using Pearson correlation coefficient...
September 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/28931340/lessons-learnt-from-early-failure-of-a-patient-trial-with-a-polymer-on-polymer-resurfacing-hip-arthroplasty
#18
Job L C Van Susante, Nico Verdonschot, L Paul A Bom, Pawel Tomaszewski, Pat Campbell, Edward Ebramzadeh, B Wim Schreurs
Background and purpose - Hip resurfacing (HR) is a treatment option promoted for hip arthritis in young and active patients. However, adverse reactions to metal are a concern and the search for non-metallic bearing options proceeds. We present the first clinical study performed in patients using a newly developed hydrophilic polymer-on-polymer hip resurfacing device. Patients and methods - After performing extensive hip simulator tests, biocompatibility testing and animal tests (ISO 14242-1,3; 10993-3,4,5,10,11), approval was obtained from the IRB committee to enroll 15 patients in the first clinical study in humans using this experimental polymer-on-polymer hip resurfacing device...
September 21, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28931328/kinetic-and-thermodynamic-parameters-and-partial-characterization-of-the-crude-extract-of-tannase-produced-by-saccharomyces-cerevisiae-ccmb-520
#19
Lúzia Morgana de Melo Lopes, Larissa Hayannyelly Costa Batista, Marcos Juliano Gouveia, Tonny Cley Campos Leite, Marcelo Rodrigues Figueira de Mello, Sandra Aparecida de Assis, Amanda Reges de Sena
Tannase can be used in different industrial sectors such as in food (juices and wine) and pharmaceutical production (trimethoprim) because it catalyses the hydrolysis of hydrolysable tannins. The aim of the current study is to assess the tannase found in the crude extract of Saccharomyces cerevisiae CCMB 520, and to set its catalytic and thermodynamic properties. The enzyme was optimally active at pH 6.0 and temperature 30 °C. Tannase was activated by Na(+), Ca(2+), K(+) at 5 × 10(-3) mol/L. The half-life at 30 °C was 3465...
September 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28931050/saxs-and-stability-studies-of-iron-induced-oligomers-of-bacterial-frataxin-cyay
#20
Mostafa Fekry, Wessen Alshokry, Przemysław Grela, Marek Tchórzewski, Eva-Christina Ahlgren, Christopher A Söderberg, Oleksandr Gakh, Grazia Isaya, Salam Al-Karadaghi
Frataxin is a highly conserved protein found in both prokaryotes and eukaryotes. It is involved in several central functions in cells, which include iron delivery to biochemical processes, such as heme synthesis, assembly of iron-sulfur clusters (ISC), storage of surplus iron in conditions of iron overload, and repair of ISC in aconitase. Frataxin from different organisms has been shown to undergo iron-dependent oligomerization. At least two different classes of oligomers, with different modes of oligomer packing and stabilization, have been identified...
2017: PloS One
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