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https://www.readbyqxmd.com/read/29031034/-potential-of-using-vitamin-d-as-an-adjuvant-treatment-of-malignant-melanoma
#1
B Bolerázska, E Ďurovcová, M Mareková
The incidence of malignant melanoma worldwide continues to grow despite the enormous advances in topical and systemic therapy. This increase is recorded regularly even in countries where, as a result of public health campaigns, dermatological examination and subsequent treatment have become more frequent. However, there have been reports of a stable or even decreasing mortality rate that seem to contradict the objective increase in its incidence. The well-known risk factors for malignant melanoma include sunburns and occasional sunbathing, whereas regular sunbathing is associated with a lower incidence...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29028078/a-natural-pharma-standard-supplement-formulation-to-control-treatment-related-toxicity-and-oxidative-stress-in-genitourinary-cancer-a-preliminary-study
#2
A Ledda, G Belcaro, M Dugall, R Luzzi, M Hosoi, B Feragalli, R Cotellese, V Cosentino, M Cosentino, R Eggenhoffner, M Pellizzato, A Fratter, L Giacomelli
OBJECTIVE: Oncological treatments are associated with toxicities that may decrease compliance to treatment in most genitourinary cancer patients. Supplementation with pharmaceutical-standardized supplement may be a supplementary method to control the side effects after chemo- and radiotherapy and the increased oxidative stress associated to treatments. This registry study evaluated a natural combination of supplements containing curcumin, cordyceps, and astaxanthin (Oncotris™) used as supplementary management in genitourinary cancer patients who had undergone oncological therapy...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29024186/fear-of-cancer-recurrence-in-oral-and-oropharyngeal-cancer-patients-an-investigation-of-the-clinical-encounter
#3
G Ozakinci, B Swash, G Humphris, S N Rogers, N J Hulbert-Williams
Fear of cancer recurrence (FCR) is common among individuals treated for cancer. Explorations of how this fear is expressed within an oncology setting and responded to are currently lacking. The aim was to investigate how head and neck cancer survivors in follow-up consultations express FCR, investigate how a healthcare professional addresses recurrence fears, and examine how survivors experience this interaction. We recorded the follow-up consultations of those participants who have reported FCR as a concern on the Patient Concerns Inventory...
October 12, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29020483/efficacy-of-low-level-laser-therapy-as-an-auxiliary-tool-for-management-of-acute-side-effects-of-head-and-neck-radiotherapy
#4
Wilfredo Alejandro González-Arriagada, Lara Maria Alencar Ramos, Marco Aurélio Carvalho Andrade, Marcio Ajudarte Lopes
INTRODUCTION: Head and neck radiotherapy (HNRT) is associated with acute and chronic side effects, some of which result in great morbidity. The aim of this study was to determine the efficacy of low-level laser therapy (LLLT) as an oral care tool for the management of these effects. MATERIAL AND METHODS: Clinical information was collected from 216 patients undergoing HNRT; these individuals were divided into a control group without laser therapy (n = 108), and a laser group (n = 108)...
October 11, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29019336/chemotherapy-induced-febrile-neutropenia-in-solid-tumours
#5
Ayman Rasmy, Mohammed Al Mashiakhi, Amal Ameen
Febrile neutropaenia (FN) is defined as an oral temperature of >38.3°C or two consecutive readings of >38.0°C for 2 hours and an absolute neutrophil count (ANC) of <0.5 × 109/l, or expected to fall below 0.5 × 109/l. Fever is one of the characteristic symptoms of FN and is usually associated with the presence of an infection caused by various microorganisms. The incidence and epidemiology of FN are variable based on different factors: (type of cancer, the age/sex of the patient, chemotherapy type /number of cycles)...
September 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29016887/phase-i-ii-trial-of-vorinostat-combined-with-temozolomide-and-radiation-therapy-for-newly-diagnosed-glioblastoma-final-results-of-alliance-n0874-abtc-02
#6
Evanthia Galanis, S Keith Anderson, C Ryan Miller, Jann N Sarkaria, Kurt Jaeckle, Jan C Buckner, Keith L Ligon, Karla V Ballman, Dennis F Moore, Michael Nebozhyn, Andrey Loboda, David Schiff, Manmeet Singh Ahluwalia, Eudocia Q Lee, Elizabeth R Gerstner, Glenn J Lesser, Michael Prados, Stuart A Grossman, Jane Cerhan, Caterina Giannini, Patrick Y Wen
Background: Vorinostat, a histone deacetylase inhibitor, has shown radiosensitizing properties in preclinical studies. This open-label, single-arm trial evaluated the maximum tolerated dose (MTD; phase I) and efficacy (phase II) of vorinostat combined with standard chemoradiation in newly diagnosed glioblastoma. Methods: Patients received oral vorinostat (300 or 400 mg/day) on days 1-5 weekly during temozolomide chemoradiation. Following a 4- to 6-week rest, patients received up to 12 cycles of standard adjuvant temozolomide and vorinostat (400 mg/day) on days 1-7 and 15-21 of each 28-day cycle...
August 22, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28987229/controversies-in-oral-and-maxillofacial-oncology
#7
REVIEW
Jacob G Yetzer
Imaging studies are essential components of tumor diagnosis, staging, assessing tumor response to neoadjuvant and adjuvant therapies, and postoperative surveillance on completion of definitive treatment. Treatment of early stage clinically node negative oral cavity squamous cell carcinoma is controversial. Approximately 3% of all head and neck tumors arise within the parotid gland and most often within the superficial lobe, lateral to the facial nerve; about 80% are benign and most are pleomorphic adenoma. In patients with dry eyes failing multiple other treatment modalities and facing ongoing pain and loss of vision, microvascular transplant of the submandibular gland is a viable option...
November 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/28984677/advances-in-the-understanding-and-management-of-mucositis-during-stem-cell-transplantation
#8
Joanne M Bowen, Hannah R Wardill
PURPOSE OF REVIEW: Mucositis is a severe and common side effect of anticancer treatments, with an incidence of between 40 and 80% depending on the cytotoxic regimen used. The most profound mucositis burden is experienced during conditioning regimens for hematopoietic stem cell transplant (HSCT), where the use of highly mucotoxic agents with or without total body irradiation leads to serious damage throughout the alimentary tract. Currently, the assessment and management of both oral and gastrointestinal mucositis lack authoritative guideline, with recommendations only achieved in narrow clinical scenarios...
October 3, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28983968/individualized-6-mercaptopurine-increments-in-consolidation-treatment-of-childhood-acute-lymphoblastic-leukemia-a-nopho-randomized-controlled-trial
#9
Morten Tulstrup, Thomas L Frandsen, Jonas Abrahamsson, Bendik Lund, Kim Vettenranta, Olafur Gisli Jonsson, Hanne Vibeke Hansen Marquart, Birgitte Klug Albertsen, Mats Heyman, Kjeld Schmiegelow
OBJECTIVES: This randomized controlled trial tested the hypothesis that children with non-high risk acute lymphoblastic leukemia could benefit from individualized 6-mercaptopurine increments during consolidation therapy (NCT00816049). Primary and secondary end points were end of consolidation minimal residual disease (MRD) positivity and event-free survival. METHODS: 392 patients were randomized to experimental and 396 to standard therapy. Patients allocated to standard therapy received oral 6-mercaptopurine (25 mg/m(2) /day) from days 30 to 85, while the experimental arm received stepwise increments of additional 25 mg/m(2) /day beginning on days 50 and/or 71 unless dose-limiting myelosuppression had occurred...
October 6, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28980780/-changes-in-the-new-tnm-classification-in-head-and-neck-oncology
#10
Silvia Lambiel, Pavel Dulguerov
The Union for International Cancer Control (UICC) published in 2017 a revised 8th edition of the TNM classification bringing numerous changes in the classification of head and neck tumors. Three new entities were introduced, namely HPV-positive oropharyngeal carcinoma, neck metastasis from an unknown primary, and skin carcinoma of the head and neck. Going beyond the traditional size of the lesions, several new predictive factors have been included, such as the depth of invasion of oral carcinoma and the extracapsular spread of neck metastasis...
October 4, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28977930/a-patient-derived-orthotopic-xenograft-pdox-mouse-model-of-a-cisplatinum-resistant-osteosarcoma-lung-metastasis-that-was-sensitive-to-temozolomide-and-trabectedin-implications-for-precision-oncology
#11
Kentaro Igarashi, Takashi Murakami, Kei Kawaguchi, Tasuku Kiyuna, Kentaro Miyake, Yong Zhang, Scott D Nelson, Sarah M Dry, Yunfeng Li, Jane Yanagawa, Tara A Russell, Arun S Singh, Hiroyuki Tsuchiya, Irmina Elliott, Fritz C Eilber, Robert M Hoffman
In the present study, we evaluated the efficacy of trabectedin (TRAB) and temozolomide (TEM) compared to cisplatinum (CDDP) on a patient-derived orthotopic xenogrraft (PDOX) of a lung-metastasis from an osteosarcoma of a patient who failed CDDP therapy. Osteosarcoma resected from the patient was implanted orthotopically in the distal femur of mice to establish PDOX models which were randomized into the following groups when tumor volume reached approximately 100 mm(3): G1, control without treatment; G2, CDDP (6 mg/kg, intraperitoneal injection, weekly, for 2 weeks); G3, TRAB (0...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28967303/laparoendoscopic-single-site-radical-cystectomy-versus-conventional-laparoscopic-radical-cystectomy-for-patient-with-bladder-urothelial-carcinoma-matched-case-control-analysis
#12
Xu Zhang, Kai Xu, Bin Lang, Bin Fu, Taoping Shi, Baojun Wang
OBJECTIVE: Laparoendoscopic single-site surgery (LESS) is increasingly popular in urology. However, data on LESS radical cystectomy (LESS-RC) are immature, and no adequate comparative study has assessed conventional laparoscopic radical cystectomy (CL-RC) versus LESS-RC. The primary aim of this study was to compare efficiency and safety of LESS-RC and CL-RC for patients with bladder urothelial carcinoma (BUC). MATERIALS AND METHODS: A retrospective and case-matched control comparative analysis was performed of patients who underwent LESS-RC (n= 54) and CL-RC (n= 108) from January 2011 to June 2015...
October 1, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28966957/practice-model-establishing-and-running-an-oral-chemotherapy-management-clinic
#13
Paige May, Kourtney LaPlant, Ashley McGee
Oral anticancer agents, while potentially more convenient and better tolerated than traditional intravenous therapy, come with significant concerns of noncompliance, adverse effects, and high cost. This presents an opportunity for health-care practitioners to develop a method to educate and support patients who are placed on these agents. To provide a detailed example of a currently established oral chemotherapy clinic and provide direction toward setting up a new clinic at other institutions. A description of the establishment of the clinic, how it is run and examples of interventions are provided...
October 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28966953/oral-agents-in-cancer-treatment-meeting-the-patients-needs-to-ensure-medication-adherence
#14
EDITORIAL
Sultan Kav
Sultan Kav, is a Professor at Baskent University, Faculty of Health Sciences Department of Nursing in Ankara, Turkey. She received her Bachelor of Nursing, Master, and PhD degrees from Hacettepe University School of Nursing in Ankara, Turkey. She has over 25 years experiences in oncology nursing; she is an active member of national and international organizations, namely, Turkish Oncology Nursing Association (TONA), International Society of Nurses in Cancer Care (ISNCC), European Oncology Nursing Society (EONS), ONS, and Multinational Association of Supportive Care in Cancer (MASCC)...
October 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28958898/the-impact-of-pancreaticoduodenectomy-on-endocrine-and-exocrine-pancreatic-function-a-prospective-cohort-study-based-on-pre-and-postoperative-function-tests
#15
Geert Roeyen, Miet Jansen, Vera Hartman, Thiery Chapelle, Bart Bracke, Dirk Ysebaert, Christophe De Block
BACKGROUND/OBJECTIVES: Studies reporting on function after pancreatic surgery are frequently based on diabetes history, fasting glycemia or random glycemia. The aim of this study was to investigate prospectively the evolution of pancreatic function in patients undergoing pancreaticoduodenectomy based on proper pre- and postoperative function tests. It was hypothesised that pancreatic function deteriorates after pancreaticoduodenectomy. METHODS: Between 2013 and 2016, 78 patients undergoing pancreaticoduodenectomy for oncologic indications had a prospective evaluation of their endocrine and exocrine pancreatic function...
September 9, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28958504/rilotumumab-plus-epirubicin-cisplatin-and-capecitabine-as-first-line-therapy-in-advanced-met-positive-gastric-or-gastro-oesophageal-junction-cancer-rilomet-1-a-randomised-double-blind-placebo-controlled-phase-3-trial
#16
Daniel V T Catenacci, Niall C Tebbutt, Irina Davidenko, André M Murad, Salah-Eddin Al-Batran, David H Ilson, Sergei Tjulandin, Evengy Gotovkin, Boguslawa Karaszewska, Igor Bondarenko, Mohamedtaki A Tejani, Anghel A Udrea, Mustapha Tehfe, Ferdinando De Vita, Cheryl Turkington, Rui Tang, Agnes Ang, Yilong Zhang, Tien Hoang, Roger Sidhu, David Cunningham
BACKGROUND: Rilotumumab is a fully human monoclonal antibody that selectively targets the ligand of the MET receptor, hepatocyte growth factor (HGF). We aimed to assess the efficacy, safety, and pharmacokinetics of rilotumumab combined with epirubicin, cisplatin, and capecitabine, and to assess potential biomarkers, in patients with advanced MET-positive gastric or gastro-oesophageal junction adenocarcinoma. METHODS: This multicentre, randomised, double-blind, placebo-controlled, phase 3 study was done at 152 centres in 27 countries...
September 25, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28958469/lenalidomide-maintenance-therapy-in-previously-treated-chronic-lymphocytic-leukaemia-continuum-a-randomised-double-blind-placebo-controlled-phase-3-trial
#17
Asher A Chanan-Khan, Andrey Zaritskey, Miklos Egyed, Samuel Vokurka, Sergey Semochkin, Anna Schuh, Jeannine Kassis, David Simpson, Jennie Zhang, Brendan Purse, Robin Foà
BACKGROUND: The efficacy and safety of lenalidomide as maintenance therapy after chemotherapy-based second-line therapy in patients with chronic lymphocytic leukaemia is unknown. Although kinase inhibitors can improve outcomes for some patients with relapsed and refractory disease, not all patients have access to these novel drugs. In this study, we aimed to assess the efficacy and safety of lenalidomide as maintenance therapy in patients with previously treated chronic lymphocytic leukaemia...
September 25, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28957881/practical-approaches-to-managing-cancer-patients-with-weight-loss
#18
Egidio Del Fabbro, Tamara A Orr, Susan M Stella
PURPOSE OF REVIEW: Poor appetite and weight loss are a source of family conflict, psychological distress, and associated with poor tolerance to chemotherapy, impaired quality of life, and decreased survival. Despite clinicians' concern about the effect of cachexia on their patients, few oncological professional organizations provide guidelines for the treatment of cancer-related weight loss. RECENT FINDINGS: Recent publications indicate there is an unmet need for addressing cachexia in patients with cancer...
September 27, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28956866/-the-importance-of-defining-methodology-for-post-marketing-observational-studies-on-cardiovascular-therapies
#19
Francesco Pelliccia, Francesco Barillà, Gaetano Tanzilli, Nicola Viceconte, Vincenzo Paravati, Enrico Mangieri, Carlo Gaudio
In recent years, a growing number of observational studies in cardiology have been carried out following the criticism that rigid design of randomized clinical trials produces information that is not applicable to the general patient. This approach is very common in several branches of medicine, first of all oncology, but has often been considered marginal in cardiology. The recent introduction of new oral anticoagulants (NOACs) on the market, however, has seen a proliferation of "real-life" studies, drawing the attention of cardiologists to the advantages and limitations of post-marketing studies...
July 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28950049/age-specific-incidence-and-treatment-patterns-of-head-and-neck-cancer-in-the-netherlands-a-cohort-study
#20
G B Halmos, L Bras, S Siesling, B F A M van der Laan, J A Langendijk, B A C van Dijk
OBJECTIVES: To explore the incidence and treatment pattern of head and neck cancer in different age groups. DESIGN: Cohort study. SETTING: Netherlands Cancer Registry. PARTICIPANTS: All new primary head and neck cancer cases diagnosed between 2010 and 2014 were included and categorised into different age groups. MAIN OUTCOME MEASURES: Tumour site, stage, treatment modality, location of diagnosis and treatment...
September 26, 2017: Clinical Otolaryngology
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