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piperacillin tazobactam

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https://www.readbyqxmd.com/read/29042838/dose-banding-of-intravenous-piperacillin-tazobactam-in-pediatric-surgical-inpatients
#1
Indrajit S Karande, Zoy Goff, Jacqueline Kewley, Shailender Mehta, Thomas Snelling
BACKGROUND: Antimicrobial doses in children are often prescribed by using an individually calculated dose per weight (e.g., mg/kg) or based on body surface area. Dosing errors are the most commonly reported medication errors in children. A "dose-banding" strategy is frequently used for some over-the-counter drugs to prevent dosing errors. It could also lead to efficiencies by enabling batch preparation of intravenous (IV) medications in hospitals. OBJECTIVES: To evaluate whether use of dose-banding for IV piperacillin-tazobactam results in acceptable dose variation from standard practice of individualized prescription of 100 mg/kg in children...
September 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29042339/clonal-dissemination-of-oxa-48-producing-enterobacter-cloacae-isolated-from-companion-animals-in-algeria
#2
Massilia Yousfi, Abdelaziz Touati, Anaelle Muggeo, Brazane Mira, Asma Bourouis, Lucien Brasme, Thomas Guillard, Christophe de Champs
OBJECTIVES: The aim of this study was to investigate carbapenemase-producing Enterobacteriaceae (CPE) in companion animals. METHODS: Between October 2015 and April 2016, 533 rectal swabs were obtained from healthy and diseased pets in different cities in Algeria. Samples collected were plated on MacConkey agar supplemented with ertapenem (0.5mg/L). The isolates were identified by MALDI-TOF mass spectroscopy. Antimicrobial susceptibility testing was performed using disk diffusion method...
October 14, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29039729/antimicrobial-activity-of-ceftolozane-tazobactam-tested-against-enterobacteriaceae-and-pseudomonas-aeruginosa-with-various-resistance-patterns-isolated-in-u-s-hospitals-2013-2016-as-part-of-the-surveillance-program-program-to-assess-ceftolozane-tazobactam-susceptibility
#3
Dee Shortridge, Michael A Pfaller, Mariana Castanheira, Robert K Flamm
This study evaluated the in vitro activity of ceftolozane-tazobactam and comparator agents tested against Enterobacteriaceae and Pseudomonas aeruginosa isolates from hospitalized patients in the United States. Ceftolozane-tazobactam is an antipseudomonal cephalosporin combined with a well-established β-lactamase inhibitor. A total of 18,960 organisms (15,223 Enterobacteriaceae and 3,737 P. aeruginosa) were consecutively collected from 32 medical centers located in all nine U.S. census divisions from 2013 to 2016...
October 17, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29036990/-drug-resistance-and-dissemination-of-new-delhi-metallo-%C3%AE-lactamase-1-positive-bacteria-in-a-patient
#4
X F Zhao, M Yuan, X Chen, X F Liu, D S Yu, J Li
Objective: The aim of this work was to report the surveillance and dissemination of NDM-1 positive bacteria in a patient and ward environment. Methods: In 2010, during the therapy for a 51 years old patient, clinical and environmental samples were collected for carbapenem resistant bacterial culture, according to the clinical microbiological examination. Strains identification and antibiotic susceptibility were tested by VITEK Compact 2 system and E-test. The bla(NDM-1) was detected by PCR and analyzed by sequencing...
October 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29027385/antimicrobial-susceptibilities-of-enterobacteriaceae-in-community-acquired-urinary-tract-infections-during-a-5-year-period-a-single-hospital-study-in-korea
#5
Jin Ju Park, Yu Bin Seo, Jacob Lee
BACKGROUND: Through investigating antimicrobial susceptibility patterns of Enterobacteriaceae in community-acquired urinary tract infection (CA-UTI), we provide basic evidence for the use of empirical antibiotics in CA-UTI. MATERIALS AND METHODS: We retrospectively reviewed the medical records of patients over the age of 19 years who visited a hospital in Seoul between January 2012 and December 2016 for a CA-UTI. Urine cultures were used to identify causative organisms...
September 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29020294/predicting-resistance-to-piperacillin-tazobactam-cefepime-and-meropenem-in-septic-patients-with-bloodstream-infection-due-to-gram-negative-bacteria
#6
M Cristina Vazquez-Guillamet, Rodrigo Vazquez, Scott T Micek, Marin H Kollef
Background: Predicting antimicrobial resistance in gram-negative bacteria (GNB) could balance the need for administering appropriate empiric antibiotics while also minimizing the use of clinically unwarranted broad-spectrum agents. Our objective was to develop a practical prediction rule able to identify patients with GNB infection at low risk for resistance to piperacillin-tazobactam (PT), cefepime (CE), and meropenem (ME). Methods: The study included adult patients with sepsis or septic shock due to bloodstream infections caused by GNB admitted between 2008 and 2015 from Barnes-Jewish Hospital...
July 10, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020249/increasing-evidence-of-the-nephrotoxicity-of-piperacillin-tazobactam-and-vancomycin-combination-therapy-what-is-the-clinician-to-do
#7
Richard R Watkins, Stan Deresinski
Early and appropriate empiric antibiotics are essential for achieving the best possible outcomes in sepsis. Yet, the choice of antibiotic therapy has become more challenging due to recent reports of nephrotoxicity with the combination of vancomycin and piperacillin/tazobactam, the "workhorse" regimen at many institutions. In this article we assess the evidence for nephrotoxicity and its possible mechanisms, provide recommendations for risk mitigation, address the advantages and disadvantages of alternative antibiotic choices, and suggest areas for future research...
July 29, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28994635/does-isolation-of-enterococcus-affect-outcomes-in-intra-abdominal-infections
#8
James M Sanders, Jeffrey M Tessier, Robert Sawyer, E P Dellinger, Preston R Miller, Nicholas Namias, Michaela West, Charles H Cook, P J O'Neill, Lena Napolitano, Rishi Rattan, Joseph Cuschieri, Jeffrey A Claridge, Chris A Guidry, Reza Askari, Kaysie Banton, Ori Rotstein, Billy J Moore, Therese M Duane
BACKGROUND: Enterococci are isolated frequently as pathogens in patients with intra-abdominal infections (IAIs) and may predict poor clinical outcomes. It remains controversial whether enterococci warrant an altered treatment approach with regard to antimicrobial treatment. PATIENTS AND METHODS: The study population was derived from the Study to Optimize Peritoneal Infection Therapy (STOP-IT) trial database. Through post hoc analysis subjects were stratified into two groups based on isolation of Enterococcus...
October 10, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28993338/activity-of-ceftolozane-tazobactam-and-ceftazidime-avibactam-against-beta-lactam-resistant-pseudomonas-aeruginosa-isolates
#9
Romney M Humphries, Janet A Hindler, Annie Wong-Beringer, Shelley A Miller
Ceftolozane-tazobactam (C/T) and ceftazidime-avibactam (CZA) minimum inhibitory concentrations were evaluated for a collection of 309 beta-lactam resistant isolates of Pseudomonas aeruginosa recovered from three institutions in Los Angeles, CA. Overall, 12.0% of isolates were susceptible to imipenem, 15.9% to meropenem, 20.7% to piperacillin-tazobactam, 24.6% to ceftazidime and 25.9% to cefepime, 72.5% to C/T and 61.8% to CZA. Among C/T-resistant isolates, 9.1% were CZA-susceptible, whereas 36.4% of CZA-resistant isolates were susceptible to C/T...
October 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28993143/ceftolozane-tazobactam-activity-against-drug-resistant-enterobacteriaceae-and-pseudomonas-aeruginosa-causing-health-care-associated-infections-in-the-asia-pacific-region-apac-minus-china-australia-and-new-zealand-report-from-an-antimicrobial-surveillance-program
#10
M A Pfaller, D Shortridge, H S Sader, M Castanheira, R K Flamm
OBJECTIVES: To evaluate the in vitro activity of ceftolozane-tazobactam and comparator agents tested against Enterobacteriaceae and Pseudomonas aeruginosa isolates from patients in the Asia-Pacific region (APAC) with health care associated infections (HAI). Ceftolozane-tazobactam is an antipseudomonal cephalosporin combined with a well-established β-lactamase inhibitor. METHODS: A total of 1,963 gram-negative organisms (489 P. aeruginosa and 1,474 Enterobacteriaceae) were consecutively collected using a prevalence-based approach from 14 medical centers in the APAC region...
October 6, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28991315/-impact-of-rational-use-of-antibiotics-in-a-third-level-clinic-in-colombia
#11
Christian J Pallares, Juan C Cataño
BACKGROUND: The increasing resistance of bacteria to antibiotics threatens the survival of patients and health costs. AIM: To determine the impact of an antimicrobial stewardship program in bacterial resistance and antibiotic consumption. MATERIALS AND METHODS: Quasi experimental study in a third level clinic in the city of Medellin, that evaluate in two time periods (pre-intervention between October 2012 and September 2013 and post intervention between October 2013 and September 2014) the impact of an antimicrobial stewardship program in terms of antibiotic consumption and bacterial ecology...
June 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28974393/supramolecular-nanofibers-self-assembled-from-cationic-small-molecules-derived-from-repurposed-poly-ethylene-teraphthalate-for-antibiotic-delivery
#12
Shaoqiong Liu, Kazuki Fukushima, Shrinivas Venkataraman, James L Hedrick, Yi Yan Yang
Low molecular weight cationic compounds were synthesized from re-purposed poly(ethylene teraphthalate) (PET) and used to self-assemble into high aspect ratio supramolecular nanofibers for encapsulation and delivery of anionic antibiotics. The antibiotic piperacillin/tazobactam (PT) was successfully loaded into the nanofibers through ionic interaction between anionic PT and the cationic nanofibers without loss of the nanofiber features. These PT-loaded nanofibers demonstrated high loading efficiency and sustained delivery for PT...
September 30, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28973124/association-of-acute-kidney-injury-with-concomitant-vancomycin-and-piperacillin-tazobactam-treatment-among-hospitalized-children
#13
Kevin J Downes, Carter Cowden, Benjamin L Laskin, Yuan-Shung Huang, Wu Gong, Matthew Bryan, Brian T Fisher, Stuart L Goldstein, Theoklis E Zaoutis
Importance: β-Lactam antibiotics are often coadministered with intravenous (IV) vancomycin hydrochloride for children with suspected serious infections. For adults, the combination of IV vancomycin plus piperacillin sodium/tazobactam sodium is associated with a higher risk of acute kidney injury (AKI) compared with vancomycin plus 1 other β-lactam antibiotic. However, few studies have evaluated the safety of this combination for children. Objective: To assess the risk of AKI in children during concomitant therapy with vancomycin and 1 antipseudomonal β-lactam antibiotic throughout the first week of hospitalization...
October 2, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28971266/automated-direct-screening-for-resistance-of-gram-negative-blood-cultures-using-the-bd-kiestra-workcell
#14
C S Heather, M Maley
Early detection of resistance in sepsis due to Gram-negative organisms may lead to improved outcomes by reducing the time to effective antibiotic therapy. Traditional methods of resistance detection require incubation times of 18 to 48 h to detect resistance. We have utilised automated specimen processing, digital imaging and zone size measurements in conjunction with direct disc susceptibility testing to develop a method for the rapid screening of Gram-negative blood culture isolates for resistance. Positive clinical blood cultures with Gram-negative organisms were prospectively identified and additional resistant mock specimens were prepared...
October 2, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28966482/comparative-evaluation-of-galactomannan-test-with-bronchoalveolar-lavage-and-serum-for-the-diagnosis-of-invasive-aspergillosis-in-patients-with-hematological-malignancies
#15
Ankit Gupta, Malini R Capoor, Trupti Shende, Bhawna Sharma, Ritin Mohindra, Jagdish Chander Suri, Dipender Kumar Gupta
INTRODUCTION: Invasive pulmonary aspergillosis (IPA) is a major cause of morbidity and mortality in patients with hematological malignancies. In recent years, testing for values of galactomannan (GM) in serum and bronchoalveolar lavage (BAL) fluid has been investigated as a diagnostic test for IPA for such patients, but global experience and consensus on optical density (OD) cutoffs, especially for BAL galactomannan remains lacking. METHODS: We performed a prospective case-control study to determine an optimal BAL GM OD cutoff for IPA in at-risk patients...
October 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28966268/investigation-of-the-efficacy-of-an-administration-plan-for-tazobactam-piperacillin-taz-pipc-and-the-incidence-of-kidney-and-hepatic-disorders
#16
Mina Senba, Keisuke Isami, Katsuya Yamashita, Kyouichi Tsumagari, Takuya Yamashina, Eiji Sasaki, Minako Tsuruta, Takanori Miyoshi, Yosei Kawamata, Aki Kozono
 Tazobactam/piperacillin (TAZ/PIPC) is widely used in the treatment of infectious disease. In this study, three hundred and sixty-three patients who were treated with the recommended dose of TAZ/PIPC were investigated for the proportion of time above the minimum inhibitory concentration (%TAM) and the frequency of renal and liver dysfunction. Of the whole patient population, 5.23%, exhibited increased creatinine levels, 9.37% and 8.82% exhibited increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, respectively...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28962545/species-distribution-and-antibiotic-susceptibility-profile-of-bacterial-uropathogens-among-patients-complaining-urinary-tract-infections
#17
Adane Bitew, Tamirat Molalign, Meseret Chanie
BACKGROUND: Urinary tract infection is the second most common type of infection and the problem is further compounded by the emergence of drug resistance in bacterial uropathogens. The aim of this study was to determine the spectrum of bacterial uropathogens and their drug resistant pattern. METHODS: A single institutional cross-sectional study was carried out at Arsho Advanced Medical laboratory from September 2015 to May 2016. A total of 712 urine samples were collected, inoculated onto primary isolation culture media, incubated at 37 °C for 18-24 h, and significant bacteriuria was determined...
September 29, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28949430/effectiveness-and-safety-of-outpatient-parenteral-antimicrobial-therapy-in-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#18
Miguel A Ponce González, Manuel Mirón Rubio, Abel Mujal Martinez, Oriol Estrada Cuxart, Dolores Fiuza Perez, Liliana Salas Reinoso, Estrella Fernández Fabrellas, Eusebi Chiner Vives
AIM: We analysed the effectiveness and safety of outpatient parenteral antibiotic therapy (OPAT) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in patients admitted to home hospitalisation units (HHU). METHODS: Retrospective multicentre study of patients with AECOPD included in the Spanish OPAT Registry during 2 years period. RESULTS: Twenty-seven hospitals included 562 episodes in 361 patients diagnosed COPD GOLD III-IV...
September 26, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28948652/pharmacokinetic-changes-of-antibiotic-antiviral-antituberculosis-and-antifungal-agents-during-extracorporeal-membrane-oxygenation-in-critically-ill-adult-patients
#19
REVIEW
J Hahn, J H Choi, M J Chang
WHAT IS KNOWN AND OBJECTIVE: Extracorporeal membrane oxygenation (ECMO) is a life-saving system used for critically ill patients with cardiac and/or respiratory failure. The pharmacokinetics (PK) of drugs can change in patients undergoing ECMO, which can result in therapeutic failure or drug toxicity requiring further management of drug complications. In this review, we discussed changes in the PK of antibiotic, antiviral, antituberculosis and antifungal agents administered to adult patients on ECMO...
September 25, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28946125/a-simple-ultra-high-performance-liquid-chromatography-high-resolution-mass-spectrometry-assay-for-the-simultaneous-quantification-of-15-antibiotics-in-plasma
#20
S Lefeuvre, J Bois-Maublanc, L Hocqueloux, L Bret, T Francia, C Eleout-Da Violante, E M Billaud, F Barbier, L Got
Antibiotic (ATB) treatment of critically ill patients with pathophysiological injuries remains a challenge due to the constant increase in antimicrobial resistance. Therapeutic drug monitoring (TDM) is advised for ATB dose adjustments to avoid suboptimal concentrations and dose-related adverse effects. Therefore, a single and reliable analytical method for a broad selection of ATBs was developed using a high-resolution mass spectrometry (HRMS) platform for frequent use in intensive care units. An UHPLC assay coupled to high resolution accurate mass acquisition has been developed for the quantification of penicillins (amoxicillin, oxacillin, piperacillin, and ticarcillin), cephalosporines (cefepime, cefotaxime, ceftazidime, and ceftriaxone), carbapenems (ertapenem, imipenem, and meropenem), lincosamide (clindamycin), quinolones (ofloxacin and ciprofloxacin) and tazobactam...
September 11, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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