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piperacillin tazobactam

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https://www.readbyqxmd.com/read/28433493/a-rare-and-emerging-pathogen-raoultella-planticola-identification-based-on-16s-rrna-in-an-infant
#1
Serkan Atıcı, Zeynep Alp Ünkar, Sevliya Öcal Demir, Gülşen Akkoç, Nurhayat Yakut, Şerife Yılmaz, Kübra Erdem, Aslı Çınar Memişoğlu, Nurver Ülger, Ahmet Soysal, Eren Özek, Mustafa Bakır
Raoultella planticola is rarely associated with clinical infection, and a limited number of pediatric cases have been reported. Herein we report a case of bacteremia presumptively secondary to bilateral conjunctivitis in an infant caused by R. planticola which was successfully treated with piperacillin-tazobactam. It should be kept in mind that R. planticola can be a pathogen in pediatric age groups.
April 19, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28431478/successful-treatment-of-multidrug-resistant-acinetobacter-baumannii-meningitis-with-ampicillin-sulbactam-in-primary-hospital
#2
Leitao Sun, Xiaohong Wang, Zefu Li
INTRODUCTION: Acinetobacter baumannii nosocomial infections, especially those due to multi-drug resistant strains, are increasingly detected. We want to find the effective treatment measures about multi-resistant Acinetobacter baumannii infections through this research. METHODOLOGY: The clinical features and the outcomes of twelve cases of nosocomial Acinetobacter baumannii meningitis treated with ampicillin sulbactam and intrathecal use of amikacin are reported in primary hospital...
April 21, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28420849/the-effective-treatment-of-lung-infection-due-to-scedosporium-prolificans-with-voriconazole-and-surgery
#3
Seiya Masukane, Yoshihiro Kitahara, Joe Okumoto, Keisuke Sasaki, Kikuo Nakano
Scedosporium prolificans is a fungus that has demonstrated resistance against most currently available antifungal agents and which causes a rapidly disseminating and potentially fatal infection. A 68-year-old woman presented with a fever and consolidation in the lung field. Her symptoms and inflammatory reaction did not improve despite treatment with tazobactam/piperacillin, meropenem, and micafungin. Scedosporium prolificans was detected from the patient's bronchial lavage fluid, and we initiated treatment with voriconazole...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28419199/should-we-revisit-the-nephrotoxic-potential-of-piperacillin-tazobactam-as-well
#4
Farrin A Manian
No abstract text is available yet for this article.
April 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28414681/what-can-erode-through-lungs-bone-and-skin
#5
J M Manalac, D Shankaranayanan, J Paul-Olivier, L Guidry, N R Sells
CASE: A 51 year old African American Man without significant past history presented with three weeks of persistent cough productive of copious yellow sputum. He denied fevers, chills, hemoptysis, dyspnea, weight or appetite changes, sick contacts, recent travel. On physical examination, the patient was afebrile and appeared comfortable. He had decreased air entry of the left lower lobe with dullness to percussion. A 5x3 cm fluctuant mass was incidentally found on the left anterior chest wall at the level of the 11th rib with yellow expressible exudate at which time the patient reported a minor trauma sustained 3 weeks prior...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28414107/antimicrobial-susceptibility-of-bacteroides-fragilis-group-organisms-in-hong-kong-by-the-tentative-eucast-disc-diffusion-method
#6
Pak-Leung Ho, Chong-Yee Yau, Lok-Yan Ho, Eileen Ling-Yi Lai, Melissa Chun-Jiao Liu, Cindy Wing-Sze Tse, Kin-Hung Chow
This study used a recently developed EUCAST disc diffusion method to measure the susceptibility of 741 B. fragilis group isolates to six antibiotics. Isolates nonsusceptible to imipenem and metronidazole by the disc method were further investigated by E-test. Species identification was obtained by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS), PCR assays and 16S rRNA sequencing. The most common species were B. fragilis (n = 424, including 81 division II and 343 division I isolates), B...
April 14, 2017: Anaerobe
https://www.readbyqxmd.com/read/28410277/use-of-population-pharmacokinetics-and-electronic-health-records-to-assess-piperacillin-tazobactam-safety-in-infants
#7
Sara Salerno, Christoph P Hornik, Michael Cohen-Wolkowiez, P Brian Smith, Lawrence C Ku, Matthew S Kelly, Reese Clark, Daniel Gonzalez
BACKGROUND: Piperacillin, in combination with tazobactam, is frequently used in infants for treating nosocomial infections, although safety data in this population are limited. Electronic health record (EHR) data can be used to evaluate drug safety in infants, but measures of drug exposure are lacking. METHODS: To relate simulated piperacillin exposure with adverse events (AEs) in infants using EHR data, we identified infants discharged from 333 neonatal intensive care units managed by the Pediatrix Medical Group between 1997 and 2012...
April 13, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28400693/ludwig-s-angina-a-nightmare-worsened-by-adverse-drug-reaction-to-antibiotics
#8
Mohamed Hisham, Mundilipalayam N Sivakumar, R S Senthil Kumar, P Nandakumar
A 52-year-old obese gentleman presented to the hospital with complaints of fever and shortness of breath for 10 days. He was admitted in the ward and treated for acute exacerbation of asthma. He was shifted to the Intensive Care Unit (ICU) for persistent fever, neck swelling, airway obstruction and desaturation. Ludwig's angina was suspected and computed tomography of neck confirmed it. A difficult airway was anticipated and preceded with surgical tracheostomy. The patient had hypersensitivity reactions to piperacillin/tazobactam; hence, he was treated with clindamycin and metronidazole...
March 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28400691/metastatic-endogenous-endophthalmitis-a-rare-presentation-with-methicillin-resistant-staphylococcus-aureus-prostatic-abscess
#9
Mrugank M Bhavsar, T V Devarajan, P Senthur Nembi, Nagarajan Ramakrishnan, Ashwin K Mani
A 62-year-old male with the previous history of uncontrolled diabetes and hypertension on irregular treatment presented with a history of fever, dysuria, and urinary retention with progressive painful loss of vision over a period of 2 days. His eye examination showed hypopyon, and he was diagnosed to have rapidly progressive endogenous endophthalmitis. He was started on vancomycin and piperacillin-tazobactam empirically. His blood and urine cultures grew methicillin-resistant Staphylococcus aureus (MRSA). Transesophageal echocardiography ruled out infective endocarditis...
March 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28399424/resistance-among-gram-negative-eskape-pathogens-isolated-from-hospitalized-patients-with-intra-abdominal-and-urinary-tract-infections-in-latin-american-countries-smart-2013-2015
#10
James A Karlowsky, Daryl J Hoban, Meredith A Hackel, Sibylle H Lob, Daniel F Sahm
Gram-negative ESKAPE pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are important etiologic agents of nosocomial infection that are frequently resistant to broad-spectrum antimicrobial agents. Gram-negative ESKAPE pathogens were collected from hospitalized patients in 11 Latin American countries from 2013 to 2015 as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART) global surveillance program. In total, 2113 isolates from intra-abdominal infections (IAI) and 970 isolates from urinary tract infections (UTI) were tested against antimicrobial agents using standardized CLSI broth microdilution methodology...
April 8, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28391954/antimicrobial-susceptibility-of-pathogens-isolated-from-surgical-site-infections-in-japan-comparison-of-data-from-nationwide-surveillance-studies-conducted-in-2010-and-2014-2015
#11
Yoshio Takesue, Shinya Kusachi, Hiroshige Mikamo, Junko Sato, Akira Watanabe, Hiroshi Kiyota, Satoshi Iwata, Mitsuo Kaku, Hideaki Hanaki, Yoshinobu Sumiyama, Yuko Kitagawa, Toru Mizuguchi, Yoshiyasu Ambo, Masafumi Konosu, Keiichiro Ishibashi, Akihisa Matsuda, Kazuo Hase, Yasushi Harihara, Koji Okabayashi, Shiko Seki, Takuo Hara, Koshi Matsui, Yoichi Matsuo, Minako Kobayashi, Shoji Kubo, Kazuhisa Uchiyama, Junzo Shimizu, Ryohei Kawabata, Hiroki Ohge, Shinji Akagi, Masaaki Oka, Toshiro Wakatsuki, Katsunori Suzuki, Kohji Okamoto, Katsunori Yanagihara
A nationwide survey was conducted in Japan from 2014 to 2015 to investigate the antimicrobial susceptibility of pathogens isolated from surgical site infections (SSI). The resulting data were compared with that obtained in an earlier survey, conducted in 2010. Seven main organisms were collected, and 883 isolates were studied. A significant reduction in methicillin resistance was observed among Staphylococcus aureus isolates, dropping from 72.5% in 2010 to 53.8% in 2014-2015 (p < 0.001). MRSA isolates with a vancomycin minimum inhibitory concentration (MIC) of 2 μg/mL accounted for 1...
April 5, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28387840/dose-optimization-of-piperacillin-tazobactam-in-critically-ill-children
#12
Pieter A J G De Cock, Sven C van Dijkman, Annick de Jaeger, Jef Willems, Mieke Carlier, Alain G Verstraete, Joris R Delanghe, Hugo Robays, Johan Vande Walle, Oscar E Della Pasqua, Peter De Paepe
Objectives: To characterize the population pharmacokinetics of piperacillin and tazobactam in critically ill infants and children, in order to develop an evidence-based dosing regimen. Patients and methods: This pharmacokinetic study enrolled patients admitted to the paediatric ICU for whom intravenous piperacillin/tazobactam (8:1 ratio) was indicated (75 mg/kg every 6 h based on piperacillin). Piperacillin/tazobactam concentrations were measured by an LC-MS/MS method...
April 6, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28382951/nosocomial-and-community-acquired-spontaneous-bacterial-peritonitis-in-patients-with-liver-cirrhosis-in-china-comparative-microbiology-and-therapeutic-implications
#13
Lei Shi, Dan Wu, Lei Wei, Suxia Liu, Peng Zhao, Bo Tu, Yangxin Xie, Yanan Liu, Xinhua Wang, Liying Liu, Xin Zhang, Zhe Xu, Fusheng Wang, Enqiang Qin
Spontaneous bacterial peritonitis (SBP) is a common complication of liver cirrhosis. This study was performed to compare the microbiological characteristics of nosocomial and community-acquired episodes of bacterial peritonitis in China. Five hundred and seventy-five strains were isolated from the ascitic fluid of cirrhotic patients from the Beijing 302 Hospital from January 2014 to December 2014. The patients in the community-acquired SBP (n = 311) and the nosocomial SBP (n = 264) groups exhibited significant differences in clinical symptoms (P < 0...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28377312/comparison-of-antipseudomonal-beta-lactams-for-febrile-neutropenia-empiric-therapy-systematic-review-and-network-meta-analysis
#14
REVIEW
Nobuyuki Horita, Yuji Shibata, Hiroki Watanabe, Ho Namkoong, Takeshi Kaneko
OBJECTIVES: Compare the effectiveness and safety of antipseudomonal beta-lactam empiric monotherapy for febrile neutropenia by network meta-analysis. METHODS: The searches using Pubmed, Cochrane CENTRAL, EMBASE, and Web of Science Core Collection were carried out in June 2016. English articles, non-English articles, full-length articles, short articles, and conference abstracts were allowed. Eligible trial design was a parallel-group individual randomization. We included febrile neutropenia adult and pediatric patients undergoing chemotherapy for either solid tumors or hematological malignanciesand treated with intravenous antipseudomonal beta-lactams for initial empiric therapy...
April 1, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28373200/the-antimicrobial-effects-of-%C3%AE-lactams-on-imipenem-resistant-ceftazidime-susceptible-pseudomonas-aeruginosa
#15
Yu Mi Wi, Ji-Young Choi, Ji-Young Lee, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song, Kwan Soo Ko
We studied the resistance mechanism and antimicrobial effects of β-lactams on imipenem-resistant Pseudomonas aeruginosa isolates susceptible to ceftazidime as detected by time-kill curve methods. Among 215 P. aeruginosa isolates from hospitalized patients in eight hospitals in Korea, 18 isolates (23.4% of 77 imipenem-resistant isolates) were both imipenem-resistant and ceftazidime-susceptible. Multilocus sequence typing revealed diverse genotypes, indicating their independent emergence. These 18 isolates were negative for carbapenemase genes...
April 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28373186/in-vitro-activity-of-pexiganan-and-10-comparator-antimicrobials-against-234-isolates-including-93-pasteurella-spp-and-50-anaerobic-bacteria-recovered-from-animal-bite-wounds
#16
Ellie J C Goldstein, Diane M Citron, Kerin L Tyrrell, Eliza S Leoncio
Animal bite wounds affect more than 5 million Americans resulting in 300,000 Emergency Department visits, 10,000 hospitalizations and untold number of physician office visits annually. Various forms of topical therapy are empirically self-employed by many patients prior to seeking medical attention. Pexiganan, a 22-amino acid synthetic cationic analogue of peptide magainin II, acts by selectively damaging bacterial cell membranes. We determined the MICs for pexiganan and other antimicrobial agents often used for treatment of bite wounds...
April 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28368076/antimicrobial-consumption-and-antimicrobial-resistance-a-snapshot-of-an-italian-neuromuscular-rehabilitation-center
#17
Giuseppina Barberi, Maria Cristina De Cola, De Cola Dell'Utri, Sara Melardi, Bernardo Alagna, Placido Bramanti, Antonio Cascio
The paper presents a snapshot of the incidence of antimicrobial-resistant microorganisms and antimicrobial consumption in an Italian rehabilitation center over a two-year period (2014-2015). Data on microorganism identification and antimicrobial susceptibility testing were obtained from the diagnostic laboratory of the hospital. A set of indicators was assessed, including the incidence density of resistant isolates per 1000 patient-days (IDRI). Data on antimicrobial consumption, semi-annually, obtained from the hospital pharmacy, were expressed as Defined Daily Dose (DDD) per 1000 patient-days...
April 3, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28368074/management-of-carbapenem-resistant-k-pneumoniae-in-allogenic-stem-cell-transplant-recipients-the-turin-bundle
#18
Francesco Giuseppe De Rosa, Silvia Corcione, Stefania Raviolo, Benedetto Bruno, Alessandro Busca
Carbapenem resistance has evolved rapidly since 2001 and the distribution of Carbapenemase-producing Klebsiella pneumoniae (CR-Kp) is currently a public health concern worldwide. In the haematological setting, especially in allogenic transplant, CR-KP infections were associated with a mortality up to 65%. Aim of this report is to describe the management of patients colonized by CR-Kp and undergoing allo-HSCT with a multiple-step intervention strategy: the "Turin bundle". Steps included oral gentamicin (GO) within 20 days before allo-HSCT, avoidance of levofloxacin prophylaxis during neutropenia, treatment of febrile neutropenia with tigecycline 100 mg bid and piperacillin-tazobactam at standard dosages and early appropriate combination therapy for patients with severe sepsis...
April 3, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28366659/antimicrobial-resistance-in-the-bacteroides-fragilis-group-in-faecal-microbiota-from-healthy-danish-children
#19
Thomas Vognbjerg Sydenham, Betina Hebbelstrup Jensen, Andreas Munk Petersen, Karen Angeliki Krogfelt, Ulrik Stenz Justesen
The Bacteroides fragilis group constitute a significant portion of the human gut microbiota and comprise a major proportion of anaerobic bacteria isolated in human infections. We established a baseline of antimicrobial susceptibility rates in the B. fragilis group in the intestinal tract of relatively antibiotic-naive healthy Danish children. From 174 faecal samples collected from children attending day care, 359 non-duplicate isolates were screened for antimicrobial susceptibility. Of these, 0.0%, 1.9%, 5...
March 31, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28365324/clinical-features-and-antimicrobial-resistance-profiles-of-important-enterobacteriaceae-pathogens-in-guangzhou-representative-of-southern-china-2001-2015
#20
Jinhong Xie, Brian M Peters, Bing Li, Lin Li, Guangchao Yu, Zhenbo Xu, Mark E Shirtliff
OBJECT: This surveillance aimed to investigate the antimicrobial resistance profiles of Enterobacteriaceae pathogens in Southern China during 2001-2015. METHODS: A total of 6858 Enterobacteriaceae isolates were collected, including 4276 E. coli, 1992 K. pneumoniae and 590 Enterobacter spp. Disk diffusion method and minimum inhibitory concentrations method were used for susceptibility testing, with results interpreted by the CLSI (2015). RESULTS: Urinary tract remained the dominant isolated site among E...
March 29, 2017: Microbial Pathogenesis
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