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Evaluation of Composite Mesh for Ventral Hernia Repair

Nadia Sutton, Melinda H MacDonald, John Lombard, Bodgan Ilie, Piet Hinoul, Douglas A Granger
Aim: To evaluate whether performing ventral hernia repairs using the Ethicon Physiomesh™ Open Flexible Composite Mesh Device in conjunction with the Ethicon Securestrap® Open Absorbable Strap Fixation Device reduces surgical time and surgeon stress levels, compared with traditional surgical repair methods. Methods: To repair a simulated ventral incisional hernia, two surgeries were performed by eight experienced surgeons using a live porcine model. One procedure involved traditional suture methods and a flat mesh, and the other procedure involved a mechanical fixation device and a skirted flexible composite mesh...
2018: Medical Devices: Evidence and Research
Sante Capitano
BACKGROUND: In open surgery, extraperitoneal sublay mesh implantation is generally preferred to intraperitoneal placement, following the same principles as in "giant prosthetic reinforcement of the visceral sac" described for inguinal hernia repair [1, 2]. Miserez and Penninckx in 2002 described an endoscopic totally preperitoneal ventral hernia repair in a small cohort of 15 cases [3]. Unfortunately, this technique has not spread, probably because of the technical difficulties that require, but not for effectiveness...
March 2018: Surgical Endoscopy
Frederik Berrevoet, Carl Doerhoff, Filip Muysoms, Steven Hopson, Marco Gallinella Muzi, Simon Nienhuijs, Eric Kullman, Tim Tollens, Mark R Schwartz, Karl LeBlanc, Vic Velanovich, Lars Nannestad Jørgensen
PURPOSE: This study assessed the recurrence rate and other safety and efficacy parameters following ventral hernia repair with a polyester composite prosthesis (Parietex™ Composite Ventral Patch [PCO-VP]). PATIENTS AND METHODS: A single-arm, multicenter prospective study of 126 patients undergoing open ventral hernia repair with the PCO-VP was performed. Patient outcomes were assessed at discharge and at 10 days, 1, 6, 12, and 24 months postoperative. RESULTS: All patients had hernioplasty for umbilical (n = 110, 87...
2017: Medical Devices: Evidence and Research
Wen Wen, Bernard Majerus, Marijke Van De Moortel, Salvatore Lobue, Didier Fobe, Patrick Philippart, Luc Berwouts, Joris Coteur, Karen Gabriels, Kurt Van der Speeten
BACKGROUND: Abdominal wall hernias are a common problem. Composite meshes placed intraperitoneally for abdominal wall hernia repair are widely used. This registry evaluated the safety and efficacy of one specific composite mesh with polypropylene and expanded polytetrafluoroethylene (Intramesh® T1) in laparoscopic ventral hernia repair. METHODS: A prospective multicentre registry with data from seven centres was collected between January 2013 and September 2014...
October 2017: Acta Chirurgica Belgica
Job C Tharappel, Jennifer W Harris, Crystal Totten, Brittany A Zwischenberger, John S Roth
BACKGROUND: Doxycycline, a nonspecific metalloproteinase (MMP) inhibitor, has been demonstrated to impact the strength of the polypropylene (PP) mesh-repaired hernia with an increase in the deposition of collagen type 1. The impact of doxycycline with porcine acellular dermal matrices (PADM) is unknown; therefore, we evaluated the impact of doxycycline administration upon hernia repair with PP and PADM mesh. METHODS: Sprague-Dawley rats weighing ~400 g underwent laparotomy with creation of a midline ventral hernia...
April 2017: Surgical Endoscopy
Jeffrey R Scott, Corey R Deeken, Robert G Martindale, Michael J Rosen
BACKGROUND: The objective of this study was to evaluate the mechanical and histological properties of a fully absorbable poly-4-hydroxybutyrate/absorbable barrier composite mesh (Phasix™ ST) compared to partially absorbable (Ventralight™ ST), fully absorbable (Phasix™), and biologically derived (Strattice™) meshes in a porcine model of ventral hernia repair. METHODS: Bilateral abdominal surgical defects were created in twenty-four Yucatan pigs, repaired with intraperitoneal (Phasix™ ST, Ventralight™ ST) or retromuscular (Phasix™, Strattice™) mesh, and evaluated at 12 and 24 weeks (n = 6 mesh/group/time point)...
September 2016: Surgical Endoscopy
S T Jayanth, Anna Pulimood, Deepak Abraham, A Rajaram, M J Paul, Aravindan Nair
BACKGROUND: Abdominal wall defects and hernias are commonly repaired with synthetic or biological materials. Adhesions and recurrences are a common problem. A study was conducted to compare Chitosan coated polypropylene mesh and a polypropylene-polydioxanone composite with oxidized cellulose coating mesh (Proceed™) in repair of abdominal wall defect in a Rabbit hernia model. METHODS: A randomized controlled experimental study was done on twelve New Zealand white rabbits...
December 2015: Annals of Medicine and Surgery
Spencer P Lake, Shuddhadeb Ray, Ahmed M Zihni, Dominic M Thompson, Jeffrey Gluckstein, Corey R Deeken
BACKGROUND: Over 100 types of soft tissue repair materials are commercially available for hernia repair applications. These materials vary in characteristics such as mesh density, pore size, and pore shape. It is difficult to determine the impact of a single variable of interest due to other compounding variables in a particular design. Thus, the current study utilized prototype meshes designed to evaluate each of these mesh parameters individually. METHODS: Five prototype meshes composed of planar, monofilament polyethylene terephthalate (PET) were evaluated in this study...
February 2015: Journal of the Mechanical Behavior of Biomedical Materials
Magdy A Sorour
BACKGROUND: Ventral and incisional hernias are common surgical problems and their repairs are among the common surgeries done by a general surgeon. Repair of a large ventral hernia is still associated with high postoperative morbidity and recurrence rates. No single approach to ventral hernia repair will be the best choice for all patients. Large ventral hernias are often better approached with open surgery but may still be problematic when the defect is too wide for primary fascial closure to be achieved, as this leaves mesh exposed, bridging the gap...
2014: International Journal of Surgery
Benjamin Levi, Peng Zhang, Jeffrey Lisiecki, Michael N Terjimanian, Jacob Rinkinen, Shailesh Agarwal, Sven A Holcombe, Jeffrey H Kozlow, Stewart C Wang, William M Kuzon
BACKGROUND: Body mass index does not allow accurate risk stratification for individuals undergoing component separation repair of ventral hernias. The authors hypothesized that tissue morphology measurements (morphomics) of preoperative computed tomography scans stratify the risk of surgical site infection in patients undergoing ventral hernia repair with a component separation technique. METHODS: The authors identified 93 patients who underwent component release ventral hernia repair (2004 to 2012)...
April 2014: Plastic and Reconstructive Surgery
Almoutaz A Eltayeb, Ibrahim A Ibrahim, Mohamed B Mohamed
BACKGROUND: The management of major omphalocoele and large incisional hernias is a common problem and constitutes a great challenge for paediatric surgeons. In most cases, the abdominal cavity is so small and does not allow immediate reduction. Prosthetic materials are becoming increasingly popular for such repair, but direct contact between the bowel and these synthetic materials carries the risk of adhesions and intestinal obstruction. The relatively new PROCEED mesh with absorbable layer in contact with the bowel and another polypropylene non-absorbable layer against the abdominal wall may not produce such adhesions...
July 2013: African Journal of Paediatric Surgery: AJPS
J A Cavallo, S C Greco, J Liu, M M Frisella, C R Deeken, B D Matthews
PURPOSE: The objective of this study was to evaluate the histologic remodeling profile and biomechanical properties of the porcine abdominal wall after repair with HDMI-crosslinked (Permacol(®)) or non-crosslinked (Strattice(®)) porcine dermis in a porcine model of ventral hernia repair. METHODS: Bilateral incisional hernias were created in Yucatan minipigs and repaired after 21 days. The repair site, including mesh and abdominal wall, was harvested after 1, 6, and 12 months and subjected to histologic analysis and uniaxial testing...
April 2015: Hernia: the Journal of Hernias and Abdominal Wall Surgery
Emmanuel E Sadava, David M Krpata, Yue Gao, Yuri W Novitsky, Michael J Rosen
BACKGROUND: Prosthetic mesh infection is one of the most challenging complications after hernia repair. We evaluate the efficacy of soaking mesh in antibiotics to prevent prosthetic infection in an animal model of clean-contaminated ventral hernia repair (VHR). MATERIAL AND METHODS: Rats underwent an acute VHR with one of four synthetic meshes (composite multifilament polyester (Parietex PCO), multifilament polyester (Parietex TET), composite monofilament polypropylene (Ventralight), or monofilament polypropylene (SoftMesh))...
March 2013: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Jeffrey A Blatnik, David M Krpata, Michael R Jacobs, Yue Gao, Yuri W Novitsky, Michael J Rosen
BACKGROUND: Synthetic mesh has significantly reduced recurrence rates for ventral hernia repair; however, prosthetic mesh infections remain a significant complication. We hypothesized that unique mesh constructs might alter the ability of various synthetic meshes to clear bacterial contamination. To evaluate this, we studied commercially available synthetic meshes ability to clear a bacterial contamination with methicillin resistant Staphylococcus aureus infection. METHODS: Two hundred and eighty-three rats underwent hernia repair with one of nine synthetic materials...
November 2012: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Alfredo Moreno-Egea, Andrés Carrillo-Alcaraz, Víctor Soria-Aledo
BACKGROUND: The use of lightweight meshes in incisional hernia repair could have beneficial effects on quality of life. This study aimed to compare a new titanium-coated lightweight mesh with a standard composite mesh after laparoscopic incisional hernia repair. METHODS: A randomized controlled single-center clinical trial was designed using the basic principle of one unit, one surgeon, one technique (midline incisional hernia with a laparoscopic approach), and two meshes: a lightweight titanium-coated mesh (group 1) and a medium-weight collagen-polyester composite mesh (group 2) used in 102 patients...
January 2013: Surgical Endoscopy
Caroline Gronnier, Jean-Michel Wattier, Hugo Favre, Guillaume Piessen, Christophe Mariette
BACKGROUND: Incisional hernia is a frequent complication following abdominal surgery. Repairs that include the use of mesh have been associated with decreased recurrence. The aim of the present study was to determine the outcomes and risk factors for chronic pain after ventral hernia repair with underlay placement of a composite polypropylene mesh. METHODS: A retrospective study was conducted from September 2005 to June 2008. The study included consecutive patients who underwent elective incisional hernia repair with underlay composite mesh placement...
July 2012: World Journal of Surgery
Jim F Byrd, Neal Agee, Phuong H Nguyen, Jessica J Heath, Kwan N Lau, Iain H McKillop, David Sindram, John B Martinie, David A Iannitti
INTRODUCTION: Composite mesh prostheses incorporate the properties of multiple materials for ventral hernia repair. This study evaluated a polypropylene/ePTFE composite mesh with a novel internal polydioxanone (PDO) absorbable ring. METHODS: Composite mesh was placed intraperitoneally in 16 pigs through an open laparotomy and explanted at 2, 4, 8, and 12 weeks. Intraabdominal adhesions were measured laparoscopically. Host tissue in-growth was assessed histologically and tensiometrically...
July 2011: JSLS: Journal of the Society of Laparoendoscopic Surgeons
C R Deeken, B D Matthews
PURPOSE: The objective of this study was to determine the mesh contracture, adhesion, tissue ingrowth, and histologic characteristics of a novel absorbable barrier mesh (Ventrio™ ST Hernia Patch) compared to existing permanent (Ventrio™ Hernia Patch) and absorbable barrier meshes (Sepramesh™ IP Composite and PROCEED™ Surgical Mesh). METHODS: Standard laparoscopic technique was utilized to bilaterally implant meshes in 20 female Yorkshire pigs (n = 5 pigs/group)...
February 2012: Hernia: the Journal of Hernias and Abdominal Wall Surgery
Ildikó Takács, Szabolcs Horváth, Ágnes Molnár, Sarolta Gáspár, Rebeka Hajós, Ágnes Meczker, Péter Kóbor, János Lantos, Szaniszló Jávor, Borbála Balatonyi, György Szekeres, Erzsébet Röth, György Wéber
Intraperitoneal surgical mesh implantation is required for laparoscopic ventral hernia repair. Composite meshes are well known in animal models and human practice. The aim of our study is to compare the biological behaviour of two different textured silicone-covered polypropylene meshes. Transmural abdominal wall defect was created in 40 rabbits and treated as follows: In 20 animals a polypropylene mesh with a laminar silicone covering (LSPP) and in the rest a macroporous textured mesh knitted of silicone-impregnated polypropylene filaments (MSPP) was applied...
2011: Histology and Histopathology
E D Jenkins, L Melman, S Desai, C R Deeken, S C Greco, M M Frisella, B D Matthews
PURPOSE: The purpose of this study is to evaluate the histologic response to fibrin sealant (FS) as an alternative fixation method for laparoscopic ventral hernia repair. METHODS: One non-absorbable barrier mesh (Composix™) and three absorbable barrier meshes (Sepramesh™, Proceed™, and Parietex™ Composite) were used for the study, with uncoated macroporous polypropylene mesh (ProLite Ultra™) as the control. Three methods of fixation were used: #0-polypropylene suture + FS (ARTISS™, Baxter Healthcare Corp...
December 2011: Hernia: the Journal of Hernias and Abdominal Wall Surgery
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