Alton Barbehenn, Lei Shi, Junzhe Shao, Rebecca Hoh, Heather M Hartig, Vivian Pae, Sannidhi Sarvadhavabhatla, Sophia Donaire, Caroline Sheikhzadeh, Jeffrey Milush, Gregory M Laird, Mignot Mathias, Kristen Ritter, Michael Peluso, Jeffrey Martin, Frederick Hecht, Christopher Pilcher, Stephanie E Cohen, Susan Buchbinder, Diane Havlir, Monica Gandhi, Timothy J Henrich, Hiroyu Hatano, Jingshen Wang, Steven G Deeks, Sulggi A Lee
Antiretroviral therapy (ART) is not a cure. Upon ART cessation, virus rapidly rebounds from latently-infected cells ("the HIV reservoir"). The reservoir is largely stabilized at the time of ART initiation and then decays slowly. Here, leveraging >500 longitudinal samples from 67 people with HIV (PWH) treated during acute infection, we developed a novel mathematical model to predict reservoir decay using the intact proviral DNA assay (IPDA) from peripheral CD4+ T cells. Nonlinear generalized additive models adjusted for initial CD4+ T count, pre-ART viral load, and timing of ART initiation demonstrated rapid biphasic decay of intact DNA (week 0-5: t 1/2 ∼0...
March 28, 2024: medRxiv