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Orbital lymphoma

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https://www.readbyqxmd.com/read/29675343/immunoglobulin-g4-related-ophthalmic-disease
#1
REVIEW
Wei-Kuang Yu, Chieh-Chih Tsai, Shu-Ching Kao, Catherine Jui-Ling Liu
Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized inflammatory disease of unknown etiology. It characterized by distinctive histopathological appearance of dense IgG4-positive lymphoplasmacytic infiltrates, storiform fibrosis, and obliterative phlebitis in one or more organs, simultaneously or subsequently. In cases of ocular adnexal involvement, unique clinicohistopathological features were delineated by recent studies, and IgG4-related ophthalmic disease (IgG4-ROD) is generally recognized as the disease name...
January 2018: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29643662/retinoblastoma-in-an-adult
#2
Vasudha Garg, Ashumi Gupta, Sonam K Pruthi, Pratima Khare
Retinoblastoma is a rare malignant tumor of the retina usually seen in children before 5 years of age. The tumor is extremely rare in adults. We report here an unusual case of retinoblastoma in a 55-year-old adult female who presented to us with an orbital mass at a late stage of the disease. Detailed laboratory investigations and imaging studies could not make a precise diagnosis. The treating ophthalmologist suspected primary intraocular tumor, metastatic carcinoma, malignant melanoma, or lymphoma and referred the patient for fine needle aspiration cytology (FNAC)...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29643136/orbital-metastasis-from-an-occult-breast-carcinoma-t0-n1-m1
#3
Rita Pinto Proença, Júlia Fernandes, Miguel N Burnier, Rui Proença
The authors report a case of an orbital metastasis from an occult breast carcinoma. A 66-year-old woman presented with a growing left orbital tumour. Orbital CT scan was consistent with lymphoma. However, ocular pathology revealed small neoplastic cells showing an 'indian file pattern' suggestive of metastatic carcinoma and immunohistochemistry was positive for CK7, CK CAM5.2 and oestrogen receptor. A systemic evaluation was then performed with mammogram, breast ultrasound and MRI considered normal. An exhaustive systemic evaluation revealed multiple bone lesions, a right axillary lymph node lesion, which presented the same pattern on pathology and immunohistochemistry, with no evidence of a primary tumour...
April 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29551574/unilateral-localized-conjunctival-amyloidosis-in-a-patient-with-a-history-of-contralateral-orbit-eyelid-lymphoma
#4
Joshua T Byers, Xin Qing, Christopher Lo, Samuel W French, Ping Ji
Amyloidosis is a disorder characterized by the deposition of insoluble abnormal proteins in the extracellular space. It may occur as a localized lesion or as a systemic disease involving multiple organs and systems. Localized conjunctival amyloidosis is rare and is less frequently associated with systemic involvement. Although amyloidosis itself is a benign lesion involvement of multiple organs and systems is associated with poor prognosis. Diagnosis of amyloidosis is made on biopsy specimens with Congo red staining for the appearance of apple-green birefringence under polarized light microscopy...
March 15, 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29503949/cystic-mucosa-associated-lymphoid-tissue-lymphoma-of-lacrimal-gland-associated-with-vision-loss-a-case-report
#5
Jacqueline Mupas-Uy, Yoshiyuki Kitaguchi, Yasuhiro Takahashi, Emiko Takahashi, Hirohiko Kakizaki
Purpose: To report an atypical case of cystic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of lacrimal gland associated with vision loss. Observations: An 89-year-old woman was presented with a rapidly progressing proptosis, lagophthalmos, and vision loss. Endophthalmitis was also present. Computed tomography scan images showed a hyperdense mass with hypodense cystic areas occupying the superolateral orbit, which displaced the globe antero-inferiorly with optic nerve compression and stretching...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29484056/primary-hepatic-mucosa-associated-lymphoid-tissue-lymphoma-in-a-patient-with-no-chronic-liver-disease-case-report
#6
Cezar I Betianu, Augustin Dima, Giorgiana Pavaloiu
Extramarginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) is a non-Hodgkin lymphoma of low-grade malignancy. The most common localization is the stomach, and the common nongastric sites are salivary glands, the skin, orbits, the conjunctiva, the lung, breasts, upper airways, other gastrointestinal sites, and the liver. Primary hepatic MALT lymphoma is a rare disease and the diagnostic can be challenging. The clinical presentation is nonspecific and may range from no symptoms to end-stage liver disease...
December 2017: Radiology Case Reports
https://www.readbyqxmd.com/read/29480273/transient-reversal-of-macular-ischemia-with-intravitreal-steroid-implant-injection-in-a-case-of-radiation-maculopathy
#7
Aditya Verma, Vikas Khetan
Diabetic retinopathy (DR) is a well-known risk factor in the development of radiation maculopathy (RM). Steroids have been shown to improve the vision and reduce the macular thickness in patients with RM. This observational case report highlights altered course of DR after a course of radiotherapy for orbital lymphoma, after a single dose of intravitreal dexamethasone implant showed a dramatic revascularization of the ischemic macula, with a significant reduction in the size of ischemic area. This appears to be the first case in literature corroborating the favorable effect on steroids on retinal vasculature, seen angiographically...
March 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29450588/response-rates-and-recurrence-patterns-after-low-dose-radiotherapy-with-4-gy-in-patients-with-low-grade-lymphomas
#8
Laila König, Juliane Hörner-Rieber, Denise Bernhardt, Adriane Hommertgen, Stefan Rieken, Jürgen Debus, Klaus Herfarth
PURPOSE: Retrospective study of effectiveness, toxicity, and relapse patterns after low-dose radiotherapy (LDRT) in patients with low-grade lymphomas. METHODS: 47 patients (median age 64 years) with 50 lesions were treated with LDRT (2 × 2 Gy). In 60%, LDRT was the primary and curative treatment, in 40% offered as second-line therapy in recurrent disease. Histology included follicular (57%) and marginal zone lymphomas (43%). Patients were followed-up regularly clinically (skin) and with CT or MRI scans...
February 15, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29446824/primary-bilateral-orbital-localization-of-malt-type-lymphoma-in-a-77-year-old-woman
#9
Selma Aissi, Amina Nasri, Samia Ben Hammouda
No abstract text is available yet for this article.
March 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29431305/the-epidemiological-clinical-and-histopathological-characteristics-of-lacrimal-gland-biopsies-in-a-tertiary-care-center-in-israel
#10
Ayelet Priel, Vicktoria Vishnevskia-Dai, Liran Hochma, Juliana Gildener-Leapman, Guy J Ben Simon, Mordechai Rosner, Gal Antman, Ofira Zloto
BACKGROUND: The distribution of pathology and clinical characteristics of lacrimal gland diseases are different in different areas of the world. OBJECTIVES: To evaluate the incidence rate, patient characteristics, and indications for surgical intervention of lacrimal gland lesions in a tertiary care center in Israel. METHODS: All biopsied or surgically removed lacrimal gland lesions at the Goldschleger Eye Institute from 2009 to 2015 were identified...
February 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29398045/-management-of-orbital-inflammation-in-internal-medicine-proposal-for-a-diagnostic-work-up
#11
S Abad, F Héran, C Terrada, P Bielefeld, D Sène, S Trad, D Saadoun, P Sève
Inflammatory orbitopathies relate to an inflammatory state originating within the orbit and its adnexes, except the inner ocular globe. Orbital inflammation (OI) may be either localized manifestation of a proven or like autoimmune disease, or local response from immune system against infectious, structural or tumoral antigens. We review the clinical manifestations of OI, which provide helpful clues to the diagnosis and describe the inflammatory, infectious and neoplastic conditions classically associated with OI...
February 1, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29375870/orbital-plasmablastic-lymphoma
#12
Edward Bloch, Fiona Robinson
Plasmablastic lymphoma is an unusual and aggressive form of diffuse large B-cell lymphoma, which arises more commonly within the oronasal mucosa. It should be considered as a differential diagnosis for rapidly growing periorbital lesions, particularly in the context of HIV positivity.
January 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29352070/review-of-extraocular-muscle-biopsies-and-utility-of-biopsy-in-extraocular-muscle-enlargement
#13
Edwina L Eade, Thomas G Hardy, Penelope A McKelvie, Alan A McNab
AIMS: To review the distribution of pathology in extraocular muscle (EOM) biopsies performed at a tertiary orbital centre, identify clinical and imaging features which are associated with benign or malignant diseases and indicate when biopsy is necessary for EOM enlargement. METHODS: Retrospective case series including 93 patients with EOM enlargement who underwent an EOM biopsy. Clinical, radiological and histopathological information was recorded from the medical records...
January 19, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29344502/orbital-epstein-barr-virus-positive-polymorphic-b-cell-lymphoproliferative-disorder-in-an-apparently-immunocompetent-woman
#14
Michael D Abendroth, Michael G Bayerl, Michael J Wilkinson, David F Claxton, Charles S Specht
We report a rare case of Epstein-Barr virus (EBV)-positive polymorphic B-cell lymphoproliferative disorder (LPD) involving the lacrimal gland of a 28-year-old, apparently immunocompetent woman. She presented with a chief complaint of orbital swelling and tenderness and was found to have a lesion involving the right lacrimal gland and distal superior and lateral rectus muscles. Histology of the lesion revealed histiocytes with pleomorphic nuclei, reactive lymphocytes, and scattered cells that resembled the Reed-Sternberg (R-S) cells of classical Hodgkin lymphoma...
December 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29319640/orbital-extranodal-marginal-zone-lymphoma-following-radiotherapy-a-report-of-2-cases
#15
Zujaja Tauqeer, Frederick A Jakobiec, Suzanne K Freitag, Michael K Yoon, Natalie Wolkow
PURPOSE: To present 2 patients in whom orbital radiation preceded the development of periorbital extranodal marginal zone lymphoma by more than a decade and to investigate the likelihood of this representing irradiation-induced malignancy. METHODS: Retrospective chart review and histopathologic study with immunohistochemistry of 2 cases. RESULTS: The first patient was a 58-year-old woman who developed an orbital mass within the vicinity of the lateral rectus muscle 17 years after external beam proton radiation therapy for an inferotemporal choroidal melanoma...
January 9, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29285637/lymphomas-in-igg4-related-disease-clinicopathologic-features-in-a-western-population
#16
Jacob R Bledsoe, Zachary S Wallace, John H Stone, Vikram Deshpande, Judith A Ferry
Lymphomas that occur in the setting of IgG4-related disease (IgG4-RD) are uncommon. Most reported cases derive from Asia and are MALT lymphomas occurring in orbital IgG4-RD. The spectrum of lymphomas among IgG4-RD patients in the Western world remains poorly defined. The aim of this study was to report our experience with lymphomas occurring in IgG4-RD. Eight cases were identified from the pathology and consultation files. The median age was 61 years (range 22-68) at IgG4-RD diagnosis and 63.5 years (range 33-79) at lymphoma diagnosis, with a M:F ratio of 4:4...
December 28, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29260074/bilateral-orbital-marginal-zone-b-cell-lymphoma-of-the-mucosa-associated-lymphoid-tissue-in-a-patient-with-hepatitis-b-virus-infection
#17
Pei-Hsuan Lin, Yoshiyuki Kitaguchi, Jacqueline Mupas-Uy, Yasuhiro Takahashi, Hirohiko Kakizaki
Purpose: To report a case of marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the bilateral orbit with chronic hepatitis B virus (HBV) infection. Observations: A 72-year-old man with chronic HBV infection presented with a bilateral proptosis with slight restriction of ocular motility for 9 months. Computed tomographic images showed well-defined, isodense masses in the bilateral superolateral orbit. Magnetic resonance images showed isointense on T1-and hyperintense on T2-weighted images, with bilateral involvements of the lateral rectus muscles reaching the superior orbital fissures...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29125145/the-2017-doyne-lecture-the-orbit-as-a-window-to-systemic-disease
#18
REVIEW
A A McNab
A very large number of disorders affect the orbit, and many of these occur in the setting of systemic disease. This lecture covers selected aspects of orbital diseases with systemic associations in which the author has a particular clinical or research interest. Spontaneous orbital haemorrhage often occurs in the presence of bleeding diatheses. Thrombosis of orbital veins and ischaemic necrosis of orbital and ocular adnexal tissues occur with thrombophilic disorders, vasculitis, and certain bacterial and fungal infections...
February 2018: Eye
https://www.readbyqxmd.com/read/29121219/clinicopathological-features-of-ocular-adnexal-mantle-cell-lymphoma-in-an-international-multicenter-cohort
#19
Marina K H Knudsen, Peter K Rasmussen, Sarah E Coupland, Bita Esmaeli, Paul T Finger, Gerardo F Graue, Hans E Grossniklaus, Jwu Jin Khong, Penny A McKelvie, Kaustubh Mulay, Elisabeth Ralfkiaer, Lene D Sjö, Geeta K Vemuganti, Bradley A Thuro, Jeremy Curtin, Steffen Heegaard
Importance: To our knowledge, the clinical features of ocular adnexal mantle-cell lymphoma (OA-MCL) have not previously been evaluated in a large multicenter cohort. Objective: To characterize the clinical features of OA-MCL. Design, Setting, and Participants: This retrospective multicenter study included patient data collected from January 1, 1980, through December 31, 2015, at 6 eye cancer centers in 4 countries. Medical records of 55 patients with OA-MCL were reviewed; the median length of follow-up was 33 months...
December 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29114307/a-rare-case-of-aggressive-huge-primary-orbital-lymphoma-with-intracranial-extension-and-bone-invasion
#20
Prabu Rau Sriram
Primary orbital lymphoma is a rare entity with only 1% of extranodal lymphomas. They usually present to ophthalmologist and surgical reserved for biopsy or tissue diagnosis. We present a patient who was referred to neurosurgery for a rapid growing orbital lymphoma. It grows from a small nodule in the eyelid to a huge, aggressive, disfiguring lesion invading bone and dura with intracranial extension within 3 months. The patient was treated with total surgical excision followed by systemic chemotherapy.
October 2017: Asian Journal of Neurosurgery
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