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https://www.readbyqxmd.com/read/29137366/p-but-not-e-or-l-selectin-mediated-rolling-adhesion-persistence-in-hemodynamic-flow-diverges-between-metastatic-and-leukocytic-cells
#1
Erin Elizabeth Edwards, Jaeho Oh, Ananyaveena Anilkumar, Katherine Gayle Birmingham, Susan Napier Thomas
The ability of leukocytic cells to engage selectins via rolling adhesion is critical to inflammation, but selectins are also implicated in mediating metastatic dissemination. Using a microfluidic- and flow-based cell adhesion chromatography experimental and analytical technique, we interrogated the cell-subtype differences in engagement and sustainment of rolling adhesion on P-, E-, and L-selectin-functionalized surfaces in physiological flow. Our results indicate that, particularly at low concentrations of P-selectin, metastatic but not leukocytic cells exhibit reduced rolling adhesion persistence, whereas both cell subtypes exhibited reduced persistence on L-selectin and high persistence on E-selectin, differences not revealed by flow cytometry analysis or reflected in the extent or velocity of rolling adhesion...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29132440/influence-of-successful-periodontal-intervention-in-renal-disease-inspired-study-protocol-for-a-randomised-controlled-pilot-clinical-trial
#2
Praveen Sharma, Paul Cockwell, Thomas Dietrich, Charles Ferro, Natalie Ives, Iain L C Chapple
BACKGROUND: Patients with chronic kidney disease (CKD) exhibit increased morbidity and mortality which is associated with an increased systemic inflammatory burden. Identifying and managing comorbid diseases that contribute to this load may inform novel care pathways that could have a beneficial impact on the morbidity/mortality associated with CKD. Periodontitis, a highly prevalent, chronic inflammatory disease affecting the supporting structures of teeth, is associated with an increased systemic inflammatory and oxidative stress burden and the successful treatment of periodontitis has been shown to reduce both...
November 13, 2017: Trials
https://www.readbyqxmd.com/read/29127726/self-reported-marijuana-use-over-25-years-and-abdominal-adiposity-the-coronary-artery-risk-development-in-young-adults-cardia-study
#3
Michael P Bancks, Reto Auer, J Jeffrey Carr, David C Goff, Catarina Kiefe, Jamal S Rana, Jared Reis, Stephen Sidney, James G Terry, Pamela J Schreiner
AIMS: We investigated the association between cumulative lifetime and current marijuana use with total abdominal adipose tissue (AT), visceral AT, subcutaneous AT, intermuscular AT, and mean liver attenuation (LA) at mid-life. DESIGN: Longitudinal and cross-sectional secondary data analysis of participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. SETTING: CARDIA field centers in Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland, CA, USA...
November 11, 2017: Addiction
https://www.readbyqxmd.com/read/29124092/dataset-of-the-livability-performance-of-the-city-of-birmingham-uk-as-measured-by-its-citizen-wellbeing-resource-security-resource-efficiency-and-carbon-emissions
#4
Joanne M Leach, Susan E Lee, Christopher T Boyko, Claire J Coulton, Rachel Cooper, Nicholas Smith, Hélène Joffe, Milena Büchs, James D Hale, Jonathan P Sadler, Peter A Braithwaite, Luke S Blunden, Valeria De Laurentiis, Dexter V L Hunt, AbuBakr S Bahaj, Katie Barnes, Christopher J Bouch, Leonidas Bourikas, Marianna Cavada, Andrew Chilvers, Stephen J Clune, Brian Collins, Ellie Cosgrave, Nick Dunn, Jane Falkingham, Patrick James, Corina Kwami, Martin Locret-Collet, Francesca Medda, Adriana Ortegon, Serena Pollastri, Cosmin Popan, Katerina Psarikidou, Nick Tyler, John Urry, Yue Wu, Victoria Zeeb, Chris D F Rogers
This data article presents the UK City LIFE1 data set for the city of Birmingham, UK. UK City LIFE1 is a new, comprehensive and holistic method for measuring the livable sustainability performance of UK cities. The Birmingham data set comprises 346 indicators structured simultaneously (1) within a four-tier, outcome-based framework in order to aid in their interpretation (e.g., promote healthy living and healthy long lives, minimize energy use, uncouple economic vitality from CO2 emissions) and (2) thematically in order to complement government and disciplinary siloes (e...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29123294/a-global-launch-in-birmingham
#5
(no author information available yet)
No abstract text is available yet for this article.
November 10, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29122807/contribution-of-the-voluntary-sector-to-mental-health-crisis-care-in-england-protocol-for-a-multimethod-study
#6
Karen Newbigging, John Mohan, James Rees, Jenny Harlock, Alex Davis
INTRODUCTION: Timely access to the right kind of support for people experiencing a mental health crisis can be problematic. The voluntary sector (VS) plays a key role in providing support and enabling access, but there is a knowledge gap concerning its contribution and interface with public services in mental health crisis care. This study aims to address this. METHODS AND ANALYSIS: The study has three empirical elements: (1) a national survey of voluntary sector organisations (VSOs) in England and national stakeholder interviews to develop a typology of organisations and interventions provided by VSOs; (2) detailed mapping of VS services in two regions through interviews and extending the national survey; (3) four case studies, identified from the regional mapping, of VS mental health crisis services and their interface with National Health Service (NHS) and local authority services, at both a system and individual level...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29075676/direct-acting-antivirals-in-kidney-transplant-patients-successful-hepatitis-c-treatment-and-short-term-reduction-in-urinary-protein-creatinine-ratios
#7
Michael R Goetsch, Ashutosh Tamhane, Mohit Varshney, Anuj Kapil, Edgar T Overton, Graham C Towns, Ricardo A Franco
BACKGROUND: The role of Hepatitis C Virus (HCV) clearance in kidney graft survival is unknown. We examined short-term trends of protein/creatinine (P/C) ratios in HCV-infected kidney transplant recipients treated with direct-acting antivirals (DAAs). METHODS: This is a retrospective study of 19 kidney transplant patients with HCV infection treated with DAAs at the University of Alabama at Birmingham between January 2013 and June 2016. Markers of glomerular damage were assessed using average urinary protein/creatinine (P/C) ratios measured pretreatment and posttreatment...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/29074930/does-student-debt-affect-dental-students-and-dentists-stress-levels
#8
J D Boyles, B Ahmed
Introduction Many studies have shown financial worries and debt to induce stress in individuals, this combined with the existing stress of being a dentist raises the question of how student debt affects students' and dentists' stress levels.Objectives Determine whether student debt has had any noticeable effect on student stress levels; investigate whether student debt has any effect on dentists' career choice; investigate whether the increase in tuition fees has influenced the number of applicants to study dentistry at the University of Birmingham...
October 27, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29071067/the-birmingham-experience-of-high-pressure-methylene-blue-dye-test-during-primary-and-revisional-bariatric-surgery-a-retrospective-cohort-study
#9
G C Kirby, C A W Macano, S M Nyasavajjala, M Sahloul, R Nijjar, M Daskalakis, M Richardson, R Singhal
INTRODUCTION: Leak following bariatric surgery continues to be associated with morbidity and rarely mortality. With improvement in surgical techniques and stapler design, leak rates have reduced drastically. Intra-operative high pressure Methylene blue leak test (HPMB) is one of the techniques employed to confirm integrity of anastomoses and staple lines. Despite this, evidence for its use remains limited. We evaluated the role of HPMB in detecting and preventing leaks. METHODS: A retrospective cohort of consecutive patients who underwent primary or revisional Laparoscopic Sleeve Gastrectomy (SG) or Laparoscopic Roux-en-Y Gastric bypass (RYGB) under the care of five surgeons in three centres across Birmingham, UK, between 2012 and 2016 were assessed...
November 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29063814/the-use-of-cannabidiol-for-seizure-management-in-patients-with-brain-tumor-related-epilepsy
#10
Paula Province Warren, E Martina Bebin, L Burt Nabors, Jerzy P Szaflarski
Epilepsy, commonly encountered by patients with brain tumors, is often refractory to standard therapies. Our aim was to examine the safety and efficacy of pharmaceutical grade cannabidiol (CBD; Epidiolex, GW Pharmaceuticals) in those patients with epilepsy with concomitant tumors enrolled in The University of Alabama at Birmingham CBD Program (NCT02700412 and NCT02695537). Of the three patients with refractory seizures and a history of a primary brain tumor, two had improvement in seizure frequency and all three had improvement in seizure severity...
October 24, 2017: Neurocase
https://www.readbyqxmd.com/read/29063151/correction-to-a-case-series-of-lateral-opening-wedge-high-tibial-osteotomy-for-valgus-malalignment
#11
Brett Collins, Alan Getgood, Abdulaziz Z Alomar, J Robert Giffin, Kevin Willits, Peter J Fowler, Trevor B Birmingham, Robert B Litchfield
Unfortunately, one of the co-author affiliation was incorrect in the original publication of this article. The correct affiliation is given below: Abdulaziz Z. Alomar, King Khalid University Hospital, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
October 23, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29061625/observational-study-of-factors-associated-with-return-of-home-sampling-kits-for-sexually-transmitted-infections-requested-online-in-the-uk
#12
Kaveh Manavi, James Hodson
OBJECTIVES: To investigate factors associated with the return of home sampling kits for sexually transmitted infections (STIs). SETTING: Online STI testing service offered to the residents of Birmingham and Solihull. PARTICIPANTS: All patients requesting STI home sampling kits via the Umbrella sexual health service website between 15 July 2016 and 14 December 2016. INTERVENTIONS: Associations between data collected at online registration and the rate of return of STI home sampling kits within 30 days of request was assessed...
October 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29055572/prescription-of-antibiotics-does-it-alter-the-outcome-for-patients-who-have-fractures-of-the-angle-of-the-mandible
#13
D Hammond, S Parmar, J Whitty, M McPhillips, R Wain
We retrospectively studied 708 consecutive patients at the Queen Elizabeth Hospital, Birmingham, to find out whether one of the four antibiotic protocols in use conferred any advantage (or disadvantage) on a patient who had a fractured angle of the mandible, and there was none. However, the time from initial injury until the time of the first dose of antibiotic was important. Clinically, if patients waited more than 72hours after the injury before the first dose of antibiotic was given, they had a three times higher rate of postoperative infection than patients who were given their first dose between 24 and 72hours after the injury...
November 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29051165/university-of-birmingham-an-innovative-masters-of-exercise-and-sports-medicine-in-partnership-with-the-football-association-continuing-professional-development-series
#14
Adam G Culvenor
No abstract text is available yet for this article.
October 19, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29045317/the-relationships-between-height-arm-length-and-leg-length-on-the-mechanics-of-the-conventional-and-high-handle-hexagonal-bar-deadlift
#15
Robert G Lockie, Matthew R Moreno, Ashley J Orjalo, Adrina Lazar, Tricia M Liu, Alyssa A Stage, Samantha A Birmingham-Babauta, John J Stokes, Dominic V Giuliano, Fabrice G Risso, DeShaun L Davis, Samuel J Callaghan
The study investigated relationships between arm (AL) and leg length (LL) and conventional deadlift (CD) and high-handle hexagonal bar deadlift (HHBD) mechanics. Twenty-three resistance-trained subjects (14 males, 9 females) completed a one-repetition maximum (1RM) CD and HHBD. A linear position transducer was used to measure: lift distance and duration; peak and mean power, velocity, and force; time to peak power and velocity; and work. Right AL and LL were measured, and AL-to-LL ratio (AL:LL) was also calculated...
October 16, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29045314/repeated-sprint-ability-in-division-i-collegiate-male-soccer-players-positional-differences-and-relationships-with-performance-tests
#16
Robert G Lockie, Matthew R Moreno, Ashley J Orjalo, Alyssa A Stage, Tricia M Liu, Samantha A Birmingham-Babauta, Jillian M Hurley, Ibett A Torne, Megan D Beiley, Fabrice G Risso, DeShaun L Davis, Adrina Lazar, John J Stokes, Dominic V Giuliano
Repeated-sprint ability (RSA) in essential for soccer. Important considerations when assessing RSA is whether there are differences between positions (defenders, midfielders, forwards), and what physiological characteristics may contribute to RSA. This has not been assessed in collegiate male players. Eighteen Division I male field players from one school performed several performance tests. The RSA test involved 7 x 30-m sprints completed on 20-s cycles. Measurements included total time (TT), and performance decrement (percent change in time from the first to last sprint; PD)...
October 16, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29033024/a-predictive-model-for-a-reputation-based-general-surgery-residency-match-and-a-novel-online-calculator
#17
John T Killian, James D Leeper, Qiong Xu, Paul F Sauer, John R Porterfield
OBJECTIVE: This study aimed to identify medical student characteristics that predict a successful categorical match into a general surgery residency and a match based upon Doximity program rankings. DESIGN: This was a retrospective study that analyzed academic and personal predictors of a successful general surgery residency match. SETTING: This study was set at the University of Alabama at Birmingham School of Medicine, a public medical school...
October 9, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29026576/use-of-granulocyte-colony-stimulating-factor-in-the-treatment-of-methimazole-induced-agranulocytosis-a-case-report
#18
Asha Birmingham, Carissa Mancuso, Craig Williams
A comparison of this case to previously published reports suggests that granulocyte colony-stimulating factor may be associated with improved prognosis in severe antithyroid drug-induced neutropenia, and that weight-based doses could be an appropriate strategy.
October 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29026295/systemic-effects-of-chronic-obstructive-pulmonary-disease-in-young-old-adults-life-space-mobility
#19
Isabel Fialho Fontenele Garcia, Carina Tiemi Tiuganji, Maria do Socorro Morais Pereira Simões, Ilka Lopes Santoro, Adriana Claudia Lunardi
PURPOSE: The objective was to assess whether dyspnea, peripheral muscle strength and the level of physical activity are correlated with life-space mobility of older adults with COPD. PATIENTS AND METHODS: Sixty patients over 60 years of age (40 in the COPD group and 20 in the control group) were included. All patients were evaluated for lung function (spirometry), life-space mobility (University of Alabama at Birmingham Study of Aging Life-Space Assessment), dyspnea severity (Modified Dyspnea Index), peripheral muscle strength (handgrip dynamometer), level of physical activity and number of daily steps (accelerometry)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29022787/does-a-missed-obstetric-anal-sphincter-injury-at-time-of-delivery-affect-short-term-functional-outcome
#20
L Ramage, C Yen, S Qiu, C Simillis, C Kontovounisios, E Tan, P Tekkis
Introduction This study aimed to ascertain whether missed obstetric anal sphincter injury at delivery had worse functional and quality of life outcomes than primary repair immediately following delivery. Materials and methods Two to one propensity matching was undertaken of patients presenting to a tertiary pelvic floor unit with ultrasound evidence of missed obstetric anal sphincter injury within 24 months of delivery with patients who underwent primary repair at the time of delivery by parity, grade of injury and time to assessment...
September 15, 2017: Annals of the Royal College of Surgeons of England
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