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https://www.readbyqxmd.com/read/28917713/the-bvas-is-an-independent-predictor-of-cardiovascular-events-and-cardiovascular-disease-related-mortality-in-patients-with-anca-associated-vasculitis-a-study-of-504-cases-in-a-single-chinese-center
#1
Yi-Hua Bai, Zhi-Ying Li, Dong-Yuan Chang, Min Chen, Cees G M Kallenberg, Ming-Hui Zhao
BACKGROUND: Cardiovascular diseases (CVD) are the major causes of death in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) during long-term follow-up. This study investigated risk factors for cardiovascular events (CVE) and CVD-related mortality in Chinese AAV patients. METHODS: Five hundred and four AAV patients in our center were retrospectively included. The predictive value of variables associated with CVE and CVD-related mortality were analyzed...
August 31, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28916432/rituximab-as-induction-therapy-in-eosinophilic-granulomatosis-with-polyangiitis-refractory-to-conventional-immunosuppressive-treatment-a-36-month-follow-up-analysis
#2
Jens Thiel, Arianna Troilo, Ulrich Salzer, Theresa Schleyer, Kirsten Halmschlag, Marta Rizzi, Natalie Frede, Ana Venhoff, Reinhard E Voll, Nils Venhoff
BACKGROUND: Rituximab (RTX) is approved for induction therapy of granulomatosis with polyangiitis and microscopic polyangiitis. In eosinophilic granulomatosis with polyangiitis (EGPA), organ-threatening manifestations are mainly treated with cyclophosphamide (CYC). RTX as treatment in EGPA has been described in small case series; however long-term data and the efficacy of RTX in EGPA refractory to CYC have not been reported yet. OBJECTIVES: To investigate the efficacy and safety of RTX and conventional immunosuppressive therapy with CYC in EGPA as induction therapy and during long-term follow-up...
September 12, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28915716/implementation-and-utilization-of-the-molecular-tumor-board-to-guide-precision-medicine
#3
REVIEW
Shuko Harada, Rebecca Arend, Qian Dai, Jessica A Levesque, Thomas S Winokur, Rongjun Guo, Martin J Heslin, Lisle Nabell, L Burt Nabors, Nita A Limdi, Kevin A Roth, Edward E Partridge, Gene P Siegal, Eddy S Yang
BACKGROUND: With rapid advances in genomic medicine, the complexity of delivering precision medicine to oncology patients across a university health system demanded the creation of a Molecular Tumor Board (MTB) for patient selection and assessment of treatment options. The objective of this report is to analyze our progress to date and discuss the importance of the MTB in the implementation of personalized medicine. MATERIALS AND METHODS: Patients were reviewed in the MTB for appropriateness for comprehensive next generation sequencing (NGS) cancer gene set testing based on set criteria that were in place...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28905437/the-use-of-traditional-herbal-medicines-amongst-south-asian-diasporic-communities-in-the-uk
#4
Sukvinder K Bhamra, Adrian Slater, Caroline Howard, Mark Johnson, Michael Heinrich
Migrant South Asian communities in the UK have brought with them their own traditional forms of medicine, yet little is known about their current use of herbal medicines (HMs) in the UK. The aim of the study was to explore the origins, use and transmission of knowledge of traditional HMs used by diasporic South Asian communities in the UK. A researcher-administered questionnaire was used for data collection (n = 192). An opportunity sampling technique was used to recruit participants across several locations in Birmingham and Leicester...
September 14, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28899966/factors-associated-with-work-productivity-among-people-with-copd-birmingham-copd-cohort
#5
Kiran K Rai, Peymané Adab, Jon G Ayres, W Stanley Siebert, Steven S Sadhra, Alice J Sitch, David A Fitzmaurice, Rachel E Jordan
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) are more likely to take time off work (absenteeism) and report poor performance at work (presenteeism) compared to those without COPD. Little is known about the modifiable factors associated with these work productivity outcomes. AIM: To assess the factors associated with work productivity among COPD patients. METHODS: Cross-sectional analysis of baseline data from a subsample (those in paid employment) of the Birmingham COPD Cohort study...
September 12, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28893496/the-short-term-effects-of-hot-packs-vs-therapeutic-whirlpool-on-active-wrist-range-of-motion-for-patients-with-distal-radius-fracture-a-randomized-controlled-trial
#6
Mike Szekeres, Joy C MacDermid, Ruby Grewal, Trevor Birmingham
STUDY DESIGN: Blinded randomized controlled trial. INTRODUCTION: It is generally accepted that heat is beneficial for improving range of motion (ROM). However, the mechanism of action is not clearly understood, and the optimal method of heat application has not been established. PURPOSE OF THE STUDY: To investigate the immediate effects of using a moist hot pack (MHP) vs therapeutic whirlpool bath (WB) for improving wrist ROM during a therapy session for patients with distal radius fracture...
September 8, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28891904/a-patient-information-leaflet-reduces-parental-anxiety-before-their-child-s-first-craniofacial-multidisciplinary-outpatient-appointment
#7
Thomas Edward Pidgeon, Christopher David Blore, Yasmin Webb, Jo Horton, Martin Evans
INTRODUCTION: It is expected that a child's first outpatient appointment with a craniofacial multidisciplinary team (MDT) instills anxiety in parents. Limited data exist on the aspects of the appointment that parents are most concerned about and what information they desire. The effect of written information provision on this cohort is unstudied. METHODS: Parents attending their child's first outpatient appointment with the Birmingham Children's Hospital Craniofacial MDT between September and December 2012 completed a questionnaire to identify concerns they had relating to the appointment...
September 7, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28888904/changes-in-biomechanical-risk-factors-for-knee-osteoarthritis-and-their-association-with-5-year-clinically-important-improvement-after-limb-realignment-surgery
#8
Trevor B Birmingham, Rebecca Moyer, Kristyn Leitch, Bert Chesworth, Dianne Bryant, Kevin Willits, Robert Litchfield, Peter J Fowler, J Robert Giffin
OBJECTIVE: To evaluate 5-year outcomes after lower limb realignment and test the hypothesis that surgery-induced changes in selected biomechanical risk factors for medial knee OA are associated with clinically important improvements. DESIGN: We prospectively evaluated patient-reported outcomes, full-limb standing radiographs and gait biomechanics before, 6 months (surgery-induced change) and 5 years after medial opening wedge high tibial osteotomy (HTO) in 170 patients (46...
September 6, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28888252/anaphylaxis-and-clinical-utility-of-real-world-measurement-of-acute-serum-tryptase-in-uk-emergency-departments
#9
Richard J Buka, Rebecca C Knibb, Richard J Crossman, Cathryn L Melchior, Aarnoud P Huissoon, Scott Hackett, Susan Dorrian, Matthew W Cooke, Mamidipudi T Krishna
BACKGROUND: British guidelines recommend that serial acute serum tryptase measurements be checked in all adults and a subset of children presenting with anaphylaxis. This is the first study reporting the clinical utility of acute serum tryptase in a "real-world" emergency department (ED) setting following the publication of the World Allergy Organization (WAO) criteria for anaphylaxis. OBJECTIVES: To (1) assess sensitivity, specificity, and positive and negative predictive values (PPV, NPV) of acute serum tryptase in anaphylaxis; (b) determine factors associated with higher acute serum tryptase levels; and (c) audit compliance of acute serum tryptase measurement in the ED...
September 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28885647/10-year-results-of-the-birmingham-hip-resurfacing-a-non-designer-case-series
#10
Thomas J A Hunter, Thomas S Moores, David Morley, Gopikanthan Manoharan, Simon G Collier, Phillip J Shaylor
INTRODUCTION: Recent controversies surrounding metal-on-metal (MoM) hip resurfacing has led to a substantial decline in its use. Despite this, there is good evidence to support the use of specific implants in select patients. PATIENTS AND METHODS: A retrospective analysis of Birmingham Hip Resurfacing (BHR) patients with a minimum of 10 years follow-up was performed. Functional scoring was performed with the Oxford Hip Score (OHS) and failure was defined as revision for any cause...
September 5, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28885270/association-between-internalized-hiv-related-stigma-and-hiv-care-visit-adherence
#11
Whitney S Rice, Kaylee Burnham, Michael J Mugavero, James L Raper, Ghislaine C Atkins, Bulent Turan
BACKGROUND: Internalized HIV-related stigma acts as a barrier to antiretroviral therapy (ART) adherence, but its effects on other HIV care continuum outcomes is unclear. METHODS: Among 196 HIV clinic patients in Birmingham, Alabama, we assessed internalized HIV-related stigma and depressive symptom severity using validated multi-item scales, and assessed ART adherence using a validated single-item measure. HIV visit adherence (attended out of total scheduled visits) was calculated using data from clinic records...
September 6, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28881457/ocular-presentation-of-myasthenia-gravis-a-natural-history-cohort
#12
Sivesh K Kamarajah, Girija Sadalage, Jonathan Palmer, Helena Carley, Paul Maddison, Arulmaran Sivaguru
INTRODUCTION: There is limited data on the natural history of untreated myasthenia gravis (MG) with ocular presentation. METHODS: We analysed 93 patients from symptom onset presenting to Birmingham Midlands Eye Centre (BMEC) from January 2004 to July 2015. We used multiple stepwise logistic regression to identify predictive factors of generalisation and Kaplan-Meier analysis on time to generalisation. RESULTS: 46% of patients developed generalised symptoms during the study period...
September 7, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28875802/colleagues-mourn-the-sudden-death-of-chief-nurse-whose-legacy-is-better-care
#13
(no author information available yet)
Tributes have been paid to the 'incredible' University Hospitals Birmingham NHS Foundation Trust chief nurse Philip Norman, who died suddenly.
September 6, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28870721/factors-associated-with-severity-of-irritable-bowel-syndrome-symptoms-in-patients-with-endometriosis
#14
Caroline E Lee, Paul J Yong, Christina Williams, Catherine Allaire
OBJECTIVE: This study sought to examine factors associated with severity of irritable bowel syndrome (IBS) by using the Birmingham IBS symptom scale in patients presenting with endometriosis to a tertiary referral centre. METHODS: A prospective research cohort of patients presenting to a tertiary referral centre for endometriosis was evaluated for the presence and severity of IBS between December 2013 and April 2015. Patients with endometriosis had a diagnosis of IBS by using the Rome III criteria and were evaluated for severity of IBS symptoms by using the Birmingham IBS symptom scale...
September 1, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28869636/structure-and-corrosion-resistance-of-co-cr-mo-alloy-used-in-birmingham-hip-resurfacing-system
#15
Ewa Dobruchowska, Monika Paziewska, Krzysztof Przybyl, Kazimierz Reszka
PURPOSE: The endoprostheses made of cobalt-chromium-molybdenum (Co-Cr-Mo) alloys belong to the group of the most popular metallic implants used for reconstruction of hip joints. For such biomaterials, the primary goal is a correct and long-term functioning in the aggressive environment of body fluids. Therefore, the purpose of this study was to examine both the morphology and the corrosion resistance of implants made of the cobalt alloy used in Birmingham Hip Resurfacing (BHR) system (Smith & Nephew)...
2017: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/28869085/success-rates-and-complications-of-autologous-onlay-bone-grafts-and-sinus-lifts-in-patients-with-congenital-hypodontia-and-after-trauma
#16
J Breeze, J Patel, M S Dover, R W Williams
Autogenous bone remains the gold standard for augmentation of the alveolar ridge in congenital hypodontia and appreciable post-traumatic deformity. This generally reflects the volume of material required for such defects and the osteogenic potential of the grafts. Morbidity at the donor site and success rates may lead to autogenous grafts being superseded by xenografts or alloplastic materials in the future, but we know of little evidence to confirm this. All patients having augmentation of the alveolar ridge or sinus lift to enable subsequent placement of implants between 01 January 2009 and 31 December 2016 were identified from a prospectively-gathered database held at the Queen Elizabeth Hospital, Birmingham...
August 28, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28864646/development-of-a-core-set-of-outcome-measures-for-large-vessel-vasculitis-report-from-omeract-2016
#17
Antoine G Sreih, Fatma Alibaz-Oner, Tanaz A Kermani, Sibel Z Aydin, Peter F Cronholm, Trocon Davis, Ebony Easley, Ahmet Gul, Alfred Mahr, Carol A McAlear, Nataliya Milman, Joanna C Robson, Gunnar Tomasson, Haner Direskeneli, Peter A Merkel
OBJECTIVE: Among the challenges in conducting clinical trials in large-vessel vasculitis (LVV), including both giant cell arteritis (GCA) and Takayasu arteritis (TA), is the lack of standardized and meaningful outcome measures. The Outcome Measures in Rheumatology (OMERACT) Vasculitis Working Group initiated an international effort to develop and validate data-driven outcome tools for clinical investigation in LVV. METHODS: An international Delphi exercise was completed to gather opinions from clinical experts on LVV-related domains considered important to measure in trials...
September 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28858939/beyond-abdominal-pain-pain-beliefs-pain-affect-and-distress-as-determinants-of-quality-of-life-in-patients-with-chronic-pancreatitis
#18
Craig E Keller, Charles Mel Wilcox, Gregory D Gudleski, Stacey Branham, Jeffrey M Lackner
GOALS: To assess the relationship between pain, psychological processes, and quality of life (QOL) in chronic pancreatitis (CP). BACKGROUND: CP is a progressive inflammatory disorder of the pancreas characteristically resulting in abdominal pain and impairing QOL. Pain due to CP is poorly understood and frequently difficult to treat. This pain has historically been understood as a peripheral process originating from the pancreas itself, but a growing body of literature is revealing an important role offered by central influences...
August 30, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28856453/long-term-results-of-birmingham-hip-resurfacing-arthroplasty-in-asian-patients
#19
Keisuke Uemura, Masaki Takao, Hidetoshi Hamada, Takashi Sakai, Kenji Ohzono, Nobuhiko Sugano
Several reports have shown good long-term results with the Birmingham hip resurfacing (BHR) arthroplasty, but little is known about the results in Asian countries where there is a high prevalence of osteonecrosis and developmental dysplasia of the hip, and many females with small femoral head sizes. Therefore, we retrospectively evaluated the long-term clinical results of the BHR in 112 Japanese patients (53 males and 59 females-130 hips) with an average age of 52 years. Implant survivorship was analyzed using the Kaplan-Meier method with the endpoint being revision for any reason...
August 30, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28854919/adaption-implementation-and-evaluation-of-collaborative-service-improvements-in-the-testing-and-result-communication-process-in-primary-care-from-patient-and-staff-perspectives-a-qualitative-study
#20
Ian J Litchfield, Louise M Bentham, Richard J Lilford, Richard J McManus, Ann Hill, Sheila Greenfield
BACKGROUND: Increasing numbers of blood tests are being ordered in primary care settings and the swift and accurate communication of test results is central to providing high quality care. The process of testing and result communication is complex and reliant on the coordinated actions of care providers, external groups in laboratory and hospital settings, and patients. This fragmentation leaves it vulnerable to error and the need to improve an apparently fallible system is apparent. However, primary care is complex and does not necessarily adopt change in a linear and prescribed manner influenced by a range of factors relating to practice staff, patients and organisational factors...
August 30, 2017: BMC Health Services Research
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