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https://www.readbyqxmd.com/read/28652820/a-higher-degree-of-expression-of-dna-methyl-transferase-1-in-cervical-cancer-is-associated-with-poor-survival-outcome
#1
Chandrika J Piyathilake, Suguna Badiga, Samuel G Borak, Janaka Weragoda, Sejong Bae, Roland Matthews, Walter C Bell, Edward E Partridge
BACKGROUND: Even though novel therapies based on aberrant DNA methylation could be of particular importance for the treatment of cervical cancer (CC) because the oncoproteins E6/E7 of high-risk human papillomaviruses, the causative agents for developing CC, have the capacity to bind and upregulate DNA methyltransferases (DNMTs), to our knowledge, no previous studies have evaluated the expression of this enzyme in CC in relation to survival outcomes. The purpose of the study was to evaluate the expression of DNMT1 in CC and its association with survival outcomes...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28648103/association-of-five-factor-score-with-the-mortality-in-japanese-patients-with-polyarteritis-nodosa
#2
Yoshiyuki Abe, Kurisu Tada, Ken Yamaji, Yoshinari Takasaki, Naoto Tamura
AIM: To determine mortality and its predictive factors in Japanese patients with polyarteritis nodosa (PAN). METHODS: This retrospective single-center study determined the mortality of 18 patients with PAN who were admitted to Juntendo University Hospital from 1994 to 2016. The variables at baseline, including patient demographics, clinical characteristics, and treatment, were analyzed for their association with mortality. RESULTS: The median age of onset was 57...
June 26, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28642513/birmingham-showcases-dental-research
#3
(no author information available yet)
No abstract text is available yet for this article.
June 23, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28636540/implementation-and-utilization-of-the-molecular-tumor-board-to-guide-precision-medicine
#4
REVIEW
Shuko Harada, Rebecca Arend, Qian Dai, Jessica A Levesque, Thomas S Winokur, Rongjun Guo, Martin J Heslin, Lisle Nabell, L Burt Nabors, Nita A Limdi, Kevin A Roth, Edward E Partridge, Gene P Siegal, Eddy S Yang
BACKGROUND: With rapid advances in genomic medicine, the complexity of delivering precision medicine to oncology patients across a university health system demanded the creation of a Molecular Tumor Board (MTB) for patient selection and assessment of treatment options. The objective of this report is to analyze our progress to date and discuss the importance of the MTB in the implementation of personalized medicine. MATERIALS AND METHODS: Patients were reviewed in the MTB for appropriateness for comprehensive next generation sequencing (NGS) cancer gene set testing based on set criteria that were in place...
June 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28633907/an-increase-in-per-patient-naloxone-requirements-in-an-opioid-epidemic
#5
Lauren E Birmingham, Jeffrey A Nielson
No abstract text is available yet for this article.
May 22, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28631698/-hepatitis-c-virus-associated-cryoglobulinemic-vasculitis-a-20-year-experience-with-treatment
#6
T M Ignatova, L V Kozlovskaya, N B Gordovskaya, O A Chernova, S Yu Milovanova, P I Novikov, T P Nekrasova, T V Beketova, N A Mukhin
AIM: To summarize the experience of a multidisciplinary therapy hospital in treating patients with hepatitis C virus (HCV)-associated cryoglobulinemic vasculitis (CV). SUBJECTS AND METHODS: Seventy-two patients (mean age, 49.4±10.3 years) with HCV-associated CV were examined and followed up for an average period of 2.8±3.6 years. The efficiency of traditional (corticosteroids ± cyclophosphamide) and selective (rituximab) immunosuppressive therapy (IST) was estimated in 31 and 15 observations, respectively, and that of antiviral therapy (AVT) in 25...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28630768/plastic-surgery-inclusion-in-the-undergraduate-medical-curriculum-perception-challenges-and-career-choice-a-comparative-study
#7
M Farid, R Vaughan, S Thomas
OBJECTIVE: The undergraduate medical curriculum has been overcrowded with core learning outcomes with no formal exposure to plastic surgery. The aim of this study was to compare medical students from two educational settings for the basic understanding, preferred learning method, and factors influencing a career choice in plastic surgery. DESIGN AND SETTING: A prospective cohort study based on a web-based anonymous questionnaire sent to final year medical students at Birmingham University (United Kingdom), McGill University (Canada), and a control group (non-medical staff)...
2017: Plastic Surgery International
https://www.readbyqxmd.com/read/28622157/predictors-of-5-year-outcomes-in-malignant-phase-hypertension-the-west-birmingham-malignant-hypertension-registry
#8
Alena Shantsila, Eduard Shantsila, D Gareth Beevers, Gregory Y H Lip
OBJECTIVE: Malignant hypertension represents a high-risk condition and there are scarce data on current clinical patterns of this condition. The aim of the study is to identify the clinical and demographic factors associated with poor outcome. METHODS: The data collected from 1958 to May 2016 included a total of 351 patients whose 5-year survival status was known: 221 white Caucasians (63%, age 51 ± 13 years, 64% male), 83 African-Caribbeans (24%, 45 ± 11 years, 61% male), and 47 South Asians (13%, 42 ± 11 years, 74% male)...
June 14, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28621180/interview-with-derek-connolly
#9
Derek Leslie Connolly
Dr Derek Connolly speaks to Adam Price-Evans, Commissioning Editor of Future Cardiology: Derek Leslie Connolly is a Consultant Interventional Cardiologist at Birmingham City Hospital (UK). He qualified from the University of Edinburgh (UK) summa cum laude in Pharmacology in 1985 and in Medicine in 1988 where he was the Brunton Medalist. As a Carnegie scholar at the University of California San Diego (CA, USA) he saw the early promise of angioplasty and changed his career plan from cardiac surgery to coronary intervention...
June 16, 2017: Future Cardiology
https://www.readbyqxmd.com/read/28617948/clinical-abstracts-of-the-british-small-animal-veterinary-association-congress-2017-birmingham-uk-april-6-9-2017
#10
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28611189/an-evaluation-of-a-coagulation-system-xprecia-stride-for-utilisation-in-anticoagulation-management
#11
Deborah McCahon, Andrea Roalfe, David A Fitzmaurice
AIM: To evaluate the reliability and performance of the Xprecia Stride coagulometer under the conditions in which it is most likely to be used. METHODS: The performance of the Xprecia Stride coagulometer was compared with a local laboratory and the CoaguChek systems routinely used for international normalised ratio (INR) estimation within one primary and one secondary care based anticoagulation clinic in Birmingham. Anticoagulation clinic personnel were trained to use the Xprecia Stride...
June 13, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28607671/epidemiology-of-ocular-trauma-in-children-requiring-hospital-admission-a-16-year-retrospective-cohort-study
#12
Kajo Bućan, Anita Matas, Josipa Marin Lovrić, Darko Batistić, Ivna Pleština Borjan, Livia Puljak, Ivona Bućan
BACKGROUND: To study the epidemiology of ocular trauma requiring hospital admission in children under 18 years in age. METHODS: This retrospective cohort study included pediatric patients with ocular injuries at the Ophthalmology Department of the Clinical Hospital Centre, Split, Croatia, from 2000 to 2015, classified according to the Birmingham Eye Trauma Terminology. RESULTS: There were 353 children hospitalized, 82% of boys (mean age 11 years) and 18% of girls (mean age 10 years)...
June 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28604031/spontaneous-gaze-selection-and-following-during-naturalistic-social-interactions-in-school-aged-children-and-adolescents-with-autism-spectrum-disorder
#13
Elina Birmingham, Krista Haley Smith Johnston, Grace Iarocci
Using a novel naturalistic paradigm allowing participants the freedom to spontaneously select and follow gaze cues in their environment, this study extends previous research conducted with younger children to determine whether school-age children with autism spectrum disorder (ASD, n = 17) demonstrate abnormal gaze following relative to typically developing (TD, n = 15) children. The participant and experimenter played a series of games, during which the experimenter pseudorandomly averted her gaze toward a social target (person) or a nonsocial target (object)...
June 12, 2017: Canadian Journal of Experimental Psychology, Revue Canadienne de Psychologie Expérimentale
https://www.readbyqxmd.com/read/28597905/stroke-prevention-in-atrial-fibrillation-past-present-and-future-comparing-the-guidelines-and-practical-decision-making
#14
Gregory Lip, Ben Freedman, Raffaele De Caterina, Tatjana S Potpara
Concepts and our approaches to stroke prevention in atrial fibrillation (AF) have changed markedly over the last decade. There has been an evolution over the approach to stroke and bleeding risk assessment, as well as new treatment options. An increasing awareness of AF has led to calls to improve the detection of and population screening for AF. Stroke and bleeding risk assessment continues to evolve, and the ongoing debate on balance between simplicity and practicality, against precision medicine will continue...
June 28, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28595862/safety-and-efficacy-of-uninterrupted-apixaban-therapy-versus-warfarin-during-atrial-fibrillation-ablation
#15
Ruchit R Shah, Ajay Pillai, Pascha Schafer, David Meggo, Tom McElderry, Vance Plumb, Takumi Yamada, Vineet Kumar, Harish Doppalapudi, Alicia Gunter, Emily Pentecost, William R Maddox
Thromboembolic cerebrovascular accident remains a rare but potentially devastating complication of catheter-based atrial fibrillation (AF) ablation. Uninterrupted oral anticoagulant therapy with warfarin has become the standard of care when performing catheter-based AF ablation. Compared with warfarin, apixaban, a factor Xa inhibitor, has been shown to reduce the risk of stroke and major bleeding in nonvalvular AF. With an increase in apixaban use for stroke prophylaxis in patients with AF, there is an increased interest in the safety and efficacy of uninterrupted apixaban therapy during AF ablation...
May 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28595497/case-study-human-body-relay-race
#16
Heather Lewis
This case presentation introduces the work of Heather Lewis, Graphic Designer from Birmingham Community Healthcare Foundation Trust, Clinical Illustration department. The graphic design team offer professional design solutions in a variety of formats such as scientific posters, banners, patient information booklets and promotional items. This particular project was requested by the Combined Community Dental Service, a Specialist Division in Birmingham.
April 2017: Journal of Visual Communication in Medicine
https://www.readbyqxmd.com/read/28594685/background-to-the-2nd-international-symposium-on-arthrogryposis
#17
Ruth Lester, Judith G Hall, Eva Pontén, Harold J P van Bosse
Arthrogryposis multiplex congenital is a relatively uncommon condition, with little consensus on treatment. In 2007, the 1st International Symposium on Arthrogryposis was held in Birmingham, United Kingdom, to bring together patients, their families, and a multinational group of health care experts in the field of arthrogryposis, to discuss various aspects of the care of patients with arthrogryposis multiplex congenital. From that meeting, there was a coalescence of thought on diagnosis and classification, a sharing of practices on treatments and their outcomes, and an agreement on future directions...
July 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28592358/engineering-waterborne-pseudomonas-aeruginosa-out-of-a-critical-care-unit
#18
Mark I Garvey, Craig W Bradley, Martyn A C Wilkinson, Christina Bradley, Elisabeth Holden
OBJECTIVE: To describe engineering and holistic interventions on water outlets contaminated with Pseudomonas aeruginosa and the observed impact on clinical P. aeruginosa patient isolates in a large Intensive Care Unit (ICU). DESIGN: Descriptive study. SETTING: Queen Elizabeth Hospital Birmingham (QEHB), part of University Hospitals Birmingham (UHB) NHS Foundation Trust is a tertiary referral teaching hospital in Birmingham, UK and provides clinical services to nearly 1 million patients every year...
May 31, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28592042/-the-significances-of-peripheral-neutrophils-cd-55-and-myeloperoxidase-expression-in-patients-with-myeloperoxidase-specific-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis
#19
X L Zhou, M J Zheng, Z W Shuai, L Zhang, M M Zhang, S Y Chen
Objective: To investigate the expression of CD(55) and myeloperoxidase (MPO) on neutrophils in patients with MPO-specific anti-neutrophil cytoplasmic antibody associated vasculitis(MPO-AAV), and analyze the relationship between the expression and clinical manifestation. Methods: Forty untreated patients with active MPO-AAV (patient group) and 30 healthy volunteers (control group) were enrolled in this study. The CD(55) on neutrophils and both membrane and cytoplasmic MPO were detected by flow cytometry. Serum fragment-from the activated complement factor B(Ba) and MPO were measured by ELISA...
June 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28591497/-anca-associated-vasculitides-at-mexico-city-s-metropolitan-eastern-area
#20
Hernando Cervera-Castillo, Francisco Blanco-Favela, Yolanda Floriberta Silva-López, Guadalupe Eugenia Paredez-Rivera, Verónica Torres-Caballero
BACKGROUND: The anti-neutrophil cytoplasmic antibody-associated (ANCA) vasculitides includes granulomatosis with polyangiitis (Wegener's) (GPW), Chrug-Strauss syndrome (CSS) and microscopic polyangiitis (MPA). Since it has low incidence in our field, there are a few published papers. The aim of this study was to report the clinical characteristics, activity and damage of these vasculitides in Mexico City's metropolitan eastern area. METHODS: We studied 28 cases with ANCA-associated vasculitis in the aforementioned area...
July 2017: Revista Médica del Instituto Mexicano del Seguro Social
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