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https://www.readbyqxmd.com/read/28340468/the-prevalence-of-hiv-among-women-with-high-grade-cervical-smear-abnormalities-in-birmingham-united-kingdom-a-prospective-cohort-study
#1
Najum S Qureshi, K Manavi
OBJECTIVE: The aim of the study was twofold: 1. To assess the acceptance for HIV screening in women attending Colposcopy clinic 2. To determine the prevalence of HIV in women presenting with high-grade cervical smear abnormalities. DESIGN: A prospective study. SETTING: Colposcopy clinic, Birmingham Women's Hospital, UK. POPULATION: Patients attending colposcopy clinic. MAIN OUTCOME MEASURES: To determine acceptance of HIV testing and prevalence in colposcopy patients with High-grade cervical smear abnormalities...
March 18, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28339364/clinical-and-prognostic-features-of-korean-patients-with-mpo-anca-pr3-anca-and-anca-negative-vasculitis
#2
Juyoung Yoo, Ho Jae Kim, Sung Soo Ahn, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
OBJECTIVES: We reclassified Korean patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) into 3 categories of AAV including MPO-ANCA, PR3-ANCA and ANCA negative vasculitis, and investigated clinical and prognostic features. METHODS: We reviewed the medical records of 133 patients with microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic GPA (EGPA), who had having either myeloperoxidase (MPO)-ANCA, proteinase 3 (PR3)-ANCA or no ANCA, and who had ever achieved the first remission...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28337860/clinical-features-and-long-term-outcomes-of-105-granulomatosis-with-polyangiitis-patients-a-single-center-experience-from-north-india
#3
Aman Sharma, Godasi S R S N K Naidu, Manish Rathi, Roshan Verma, Manish Modi, Benzeeta Pinto, Kusum Sharma, Varun Dhir, Manphool Singhal, Mahesh Prakash, Ritambhra Nada, Naresh K Panda, Ranjana W Minz
AIM: To describe the clinical features, treatment and long-term outcomes in north Indian patients with granulomatosis with polyangiitis (GPA). METHODS: Clinical details, Birmingham Vasculitis Activity Score (BVAS-v3), laboratory data, histopathology findings, treatment details and outcomes of all consecutive patients diagnosed as having GPA between April 2005 and April 2016 were retrieved. European Vasculitis Study Group definitions were used to classify patients into localized, early systemic, generalized, severe and refractory categories...
March 24, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28333172/aesthetic-breast-surgery-and-concomitant-procedures-incidence-and-risk-factors-for-major-complications-in-73-608-cases
#4
Varun Gupta, Max Yeslev, Julian Winocour, Ravinder Bamba, Charles Rodriguez-Feo, James C Grotting, K Kye Higdon
Background: Major complications following aesthetic breast surgery are uncommon and thus assessment of risk factors is challenging. Objectives: To determine the incidence and risk factors of major complications following aesthetic breast surgery and concomitant procedures. Methods: A prospective cohort of patients who enrolled into the CosmetAssure (Birmingham, AL) insurance program and underwent aesthetic breast surgery between 2008 and 2013 was identified...
January 20, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28328960/norms-and-stigma-regarding-pregnancy-decisions-during-an-unintended-pregnancy-development-and-predictors-of-scales-among-young-women-in-the-u-s-south
#5
Whitney S Rice, Bulent Turan, Kristi L Stringer, Anna Helova, Kari White, Kate Cockrill, Janet M Turan
BACKGROUND: Norms and stigma regarding pregnancy decisions (parenting, adoption, and abortion) are salient to maternal well-being, particularly for groups disproportionately affected by unintended pregnancy. However, there are few validated measures of individual-level perceptions of norms and stigma around pregnancy decisions. Additionally, little is known about variation in the content of norms regarding pregnancy decisions, and in stigma related to violations of these norms, across socio-demographic groups...
2017: PloS One
https://www.readbyqxmd.com/read/28328552/il-1%C3%AE-levels-are-associated-with-chronic-multisite-pain-in-people-living-with-hiv
#6
Jessica S Merlin, Andrew O Westfall, Sonya L Heath, Burel R Goodin, Jesse C Stewart, Robert E Sorge, Jarred Younger
BACKGROUND: The pathophysiology of chronic pain experienced by people living with HIV (PLWH) in the current antiretroviral treatment era is poorly understood. We sought to investigate the relationship between inflammation and chronic pain in PLWH. We hypothesized that, among PLWH who have undetectable HIV viral loads, those with Chronic Multisite Pain (CMP) would have higher levels of circulating pain-related inflammatory markers than those without chronic pain. SETTING: This study was conducted at the University of Alabama at Birmingham's Center for AIDS Research Network of Integrated Clinical System (CNICS) site...
March 20, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28320147/malignancy-in-guillain-barr%C3%A3-syndrome-a-twelve-year-single-center-study
#7
Fu Liong Hiew, Yusuf A Rajabally
The relationship between Guillain-Barré syndrome (GBS) and malignancy is uncertain. We retrospectively analyzed data of 118 consecutive patients admitted with GBS from Birmingham, U.K. (2001-2012). We calculated relative cancer risk using different definitions and determined characteristics of malignancy-associated GBS. Malignancy was globally commoner in our GBS cohort compared to the general population (odds ratio: 2.08; CI: 1.06-3.71; p=0.036). However, this was unconfirmed if paraneoplastic criteria were applied...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319741/influence-of-sampling-approach-on-concentrations-of-legacy-and-novel-brominated-flame-retardants-in-indoor-dust
#8
Layla Salih Al-Omran, Stuart Harrad
The study investigates the impact of sampling method on the concentrations of PBDEs (BDE-28, BDE-47, BDE-99, BDE-100, BDE-153, BDE-154, BDE-183, and BDE-209) and NBFRs (PBEB, EH-TBB, BEH-TEBP, BTBPE and DBDPE) in indoor dust. A total of 36 dust samples were collected from 12 homes in Birmingham, UK (3 samples per home comprising researcher collected dust - both RCD from the living room (RCDL) and bedroom (RCDB), with an additional householder vacuum dust sample - HHVD). BDE-209 was the predominant compound, with average concentrations of 2642, 2336 and 2634 ng/g in RCDL, RCDB and HHVD respectively...
February 22, 2017: Chemosphere
https://www.readbyqxmd.com/read/28319113/combinatorial-crispr-cas9-screens-for-de-novo-mapping-of-genetic-interactions
#9
John Paul Shen, Dongxin Zhao, Roman Sasik, Jens Luebeck, Amanda Birmingham, Ana Bojorquez-Gomez, Katherine Licon, Kristin Klepper, Daniel Pekin, Alex N Beckett, Kyle Salinas Sanchez, Alex Thomas, Chih-Chung Kuo, Dan Du, Assen Roguev, Nathan E Lewis, Aaron N Chang, Jason F Kreisberg, Nevan Krogan, Lei Qi, Trey Ideker, Prashant Mali
We developed a systematic approach to map human genetic networks by combinatorial CRISPR-Cas9 perturbations coupled to robust analysis of growth kinetics. We targeted all pairs of 73 cancer genes with dual guide RNAs in three cell lines, comprising 141,912 tests of interaction. Numerous therapeutically relevant interactions were identified, and these patterns replicated with combinatorial drugs at 75% precision. From these results, we anticipate that cellular context will be critical to synthetic-lethal therapies...
March 20, 2017: Nature Methods
https://www.readbyqxmd.com/read/28301825/combined-versus-individual-effects-of-a-valgus-knee-brace-and-lateral-wedge-foot-orthotic-during-stair-use-in-patients-with-knee-osteoarthritis
#10
Rebecca Moyer, Trevor Birmingham, Colin Dombroski, Robert Walsh, J Robert Giffin
The aim of this study was to investigate the combined and individual biomechanical effects of a valgus knee brace and a lateral wedge foot orthotic during stair ascent and descent in patients with knee osteoarthritis (OA). Thirty-five patients with varus alignment and medial knee OA were prescribed a custom valgus knee brace and lateral wedge foot orthotic. Knee angles and moments in the frontal and sagittal planes were determined from 3D gait analysis completed under four randomized conditions: (1) control (no knee brace or foot orthotic), (2) knee brace, (3) foot orthotic, and (4) combined knee brace and foot orthotic...
March 1, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28290234/preliminary-validation-study-of-the-russian-birmingham-cognitive-screen
#11
E Kuzmina, G W Humphreys, M J Riddoch, A A Skvortsov, B S Weekes
INTRODUCTION: The Birmingham Cognitive Screen (BCoS) is designed for use with individuals who have acquired language impairment following stroke. Our goal was to develop a Russian version of the BCoS (Rus-BCoS) by translating the battery following cultural and linguistic adaptations and establishing preliminary data on its psychometric properties. METHOD: Fifty patients with left-hemisphere stroke were recruited, of whom 98% were diagnosed with mild to moderate aphasia...
March 14, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28283043/birmingham-beh%C3%A3-et-s-service-classification-of-disease-and-application-of-the-2014-international-criteria-for-beh%C3%A3-et-s-disease-icbd-to-a-uk-cohort
#12
Tim Blake, Luke Pickup, David Carruthers, Erika Marie Damato, Alastair Denniston, John Hamburger, Claire Maxton, Debbie Mitton, Philip I Murray, Peter Nightingale, Ana Poveda-Gallego, Andrea Richards, Andrew Whallett, Deva Situnayake
BACKGROUND: This study reports on the analysis of the application and diagnostic predictability of the revised 2014 ICBD criteria in an unselected cohort of UK patients, and the ensuing organ associations and patterns of disease. METHODS: A retrospective cohort study was conducted using a database of electronic medical records. Three categories were recognised: clinically defined BD, incomplete BD and rejected diagnoses of BD. We applied the ISG 1990 and ICBD 2014 classification criteria to these subgroups to validate diagnostic accuracy against the multidisciplinary assessment...
March 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28275023/bilateral-fixation-of-a-periprosthetic-intertrochanteric-hip-fracture-below-birmingham-hip-resurfacing
#13
J Macdonald, R Pagoti, L Cusick
This case report involves a 59-year-old woman with a traumatic right intertrochanteric hip fracture below a previous Birmingham hip resurfacing (BHR). This woman had almost an identical fracture on the left hip 3 years before which was treated with a proximal femoral locking compression plate. Of note periprosthetic fractures following hip resurfacing are usually subcapital and treated with a revision or conservative management. We present an unusual surgical problem that has occurred twice in the same patient and has been treated effectively on both occasions using proximal femoral plating...
March 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28270407/impact-of-elective-versus-required-medical-school-research-experiences-on-career-outcomes
#14
Alice N Weaver, Tyler R McCaw, Matthew Fifolt, Lisle Hites, Robin G Lorenz
Many US medical schools have added a scholarly or research requirement as a potential intervention to increase the number of medical students choosing to become academic physicians and physician scientists. We designed a retrospective qualitative survey study to evaluate the impact of medical school research at the University of Alabama at Birmingham (UAB) on career choices. A survey tool was developed consisting of 74 possible questions with built-in skip patterns to customize the survey to each participant...
March 7, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28262076/cqc-praises-nurses-in-birmingham
#15
(no author information available yet)
Birmingham Children's Hospital NHS Foundation Trust has become the first children's hospital to be rated outstanding by the Care Quality Commission (CQC).
March 6, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/28262070/developing-a-website-to-demonstrate-clinical-holding-techniques
#16
Andrea Page, Alison Warren, Nicola Vanes
Healthcare staff routinely use clinical holding to help infants, children or young people stay still when treatment is being administered, to prevent children or young people from interfering with the treatment, or when invasive examinations are being carried out. However, healthcare staff rarely have any formal discussion with children and young people, or their parents, on the techniques used for clinical holding. Visual tools are important when talking to children or young people about their healthcare, and a website with images of clinical holds would allow staff to discuss relevant holds with their patients...
March 6, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/28261885/abstracts-from-the-2016-bda-research-symposium-7-december-2016-birmingham-uk
#17
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28253908/normalization-and-microbial-differential-abundance-strategies-depend-upon-data-characteristics
#18
Sophie Weiss, Zhenjiang Zech Xu, Shyamal Peddada, Amnon Amir, Kyle Bittinger, Antonio Gonzalez, Catherine Lozupone, Jesse R Zaneveld, Yoshiki Vázquez-Baeza, Amanda Birmingham, Embriette R Hyde, Rob Knight
BACKGROUND: Data from 16S ribosomal RNA (rRNA) amplicon sequencing present challenges to ecological and statistical interpretation. In particular, library sizes often vary over several ranges of magnitude, and the data contains many zeros. Although we are typically interested in comparing relative abundance of taxa in the ecosystem of two or more groups, we can only measure the taxon relative abundance in specimens obtained from the ecosystems. Because the comparison of taxon relative abundance in the specimen is not equivalent to the comparison of taxon relative abundance in the ecosystems, this presents a special challenge...
March 3, 2017: Microbiome
https://www.readbyqxmd.com/read/28247799/children-s-hospital-nurses-outstanding
#19
(no author information available yet)
Nurses at Birmingham Children's Hospital NHS Foundation Trust won praise after it became the first children's hospital to be rated outstanding overall by the Care Quality Commission.
March 1, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28239964/training-in-metabolomics-research-ii-processing-and-statistical-analysis-of-metabolomics-data-metabolite-identification-pathway-analysis-applications-of-metabolomics-and-its-future
#20
S Barnes, H P Benton, K Casazza, S J Cooper, X Cui, X Du, J Engler, J H Kabarowski, S Li, W Pathmasiri, J K Prasain, M B Renfrow, H K Tiwari
Metabolomics is perhaps the most challenging of the -omics fields, given the complexity of an organism's metabolome and the rapid rate at which it changes. When one sets out to study metabolism there are numerous dynamic variables that can influence metabolism that must be considered. Recognizing the experimental challenges confronting researchers who undertake metabolism studies, workshops like the one at University of Alabama at Birmingham have been established to offer instructional guidance. A summary of the UAB course training materials is being published as a two-part Special Feature Tutorial...
August 2016: Journal of Mass Spectrometry: JMS
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