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https://www.readbyqxmd.com/read/28096700/sequential-combination-chemotherapy-of-dacarbazine-dtic-with-carboplatin-and-paclitaxel-for-patients-with-metastatic-mucosal-melanoma-of-nasal-cavity-and-paranasal-sinuses
#1
W Omata, A Tsutsumida, K Namikawa, A Takahashi, K Oashi, N Yamazaki
By the recent introduction of molecular targeting drugs against BRAF mutation and immune checkpoint inhibitors, the prognosis of patients with melanoma in advanced stage is now improving, but still in the minority. Mucosal melanoma lacks the BRAF mutations, and hence conventional chemotherapeutic regimens must be improved. We have conventionally used dacarbazine (DTIC) for patients with metastatic mucosal melanoma. However, the efficacy of DTIC in patients with metastatic mucosal melanoma has been limited. Therefore, we explored other possibilities to improve the prognosis of patients suffering from metastatic mucosal melanoma...
2017: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/28092140/a-systematic-review-of-sinonasal-oncocytomas-and-oncocytic-carcinomas-diagnosis-management-and-technical-considerations
#2
REVIEW
Zerina Hodzic, Nicholas R Rowan, Ryota Kashiwazaki, Thomas J Willson, Eric W Wang, Stella E Lee
BACKGROUND: Oncocytomas and oncocytic carcinomas are rare tumors of the sinonasal cavity with the propensity for local invasion. This report and systematic review details a case of a nasal oncocytoma involving the lacrimal sac and provides an update of the current literature. METHODS: A systematic literature review was performed using PubMed and Ovid databases. The data obtained from published articles with sinonasal oncocytoma/oncocytic carcinoma as the primary diagnosis included patient demographics, presentation, radiographic and histologic findings, management, and recurrence rates...
January 16, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28078863/nasal-irrigation-with-nasir%C3%A2-in-children-a-preliminary-experience-on-nasal-cytology
#3
M Gelardi, S Taliente, K Piccininni, G Silvestre, N Quaranta, G Ciprandi
Allergic rhinitis (AR) and upper airway respiratory infections are frequent in children, and both have a relevant impact on some social aspects, including school attendance and performance, sleep, quality of life (also of the parents), and costs. Saline nasal irrigation is widely employed to reduce nasal congestion and mucopurulent secretion, to stimulate cleansing of the nasal and paranasal cavities, and to induce restoration of mucociliary clearance. The present study evaluated the effects of nasal irrigation on nasal cytology, using the new device Nasir® in 66 children (40 males, 26 females, mean age 7...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28061502/brain-abscesses-associated-with-asymptomatic-pulmonary-arteriovenous-fistulas
#4
Taek-Kyun Nam, Yong-Sook Park, Jeong-Taik Kwon
Brain abscess commonly occurs secondary to an adjacent infection (mostly in the middle ear or paranasal sinuses) or due to hematogenous spread from a distant infection or trauma. Pulmonary arteriovenous fistulas (AVFs) are abnormal direct communications between the pulmonary artery and vein. We present two cases of brain abscess associated with asymptomatic pulmonary AVF. A 65-year-old woman was admitted with a headache and cognitive impairment that aggravated 10 days prior. An magnetic resonance (MR) imaging revealed a brain abscess with severe edema in the right frontal lobe...
January 1, 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28060384/effects-of-functional-endoscopic-sinus-surgery-on-the-acoustics-of-the-sinonasal-tract
#5
M Havel, S Becker, M Schuster, T Johnson, A Maier, J Sundberg
BACKGROUND: Nasal and paranasal cavities are supposed to contribute substantially to the vocal tract resonator properties. However, their acoustical effects as well as the effects of sinus surgery on the voice remain unclear. In this work we investigate resonance phenomena of paranasal sinuses prior to and after various rhinosurgical procedures in cadaveric human sinonasal tracts and corresponding 3D casts. METHODOLOGY: Nasal and paranasal cavities of formalin-preserved cadavers and corresponding 3D replicas were excited by sine-tone sweeps from an earphone placed in the epipharynx...
January 6, 2017: Rhinology
https://www.readbyqxmd.com/read/28060113/adherence-to-treatment-response-and-patterns-of-failure-in-pediatric-parameningeal-rhabdomyosarcoma-experience-from-a-tertiary-cancer-care-center-from-india
#6
Soumyajit Roy, Sushmita Pathy, Bidhu K Mohanti, Subhash Chander, Ahitagni Biswas
The study was aimed at evaluating adherence to treatment protocol and outcome in pediatric parameningeal rhabdomyosarcoma (PM-RMS). We analyzed the characteristics, treatment administered, outcomes and patterns of failure of pediatric PM-RMS, who were treated with multimodality therapy between January 2005 and December 2013.Univariate and multivariate analysis (MVA) was completed to evaluate the impact of various prognostic factors. Thirty-seven patients were treated at our institution. Majority of them had the primary disease in paranasal sinuses (n=13)...
January 5, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28060098/the-manangement-of-the-paranasal-sinus-osteomas
#7
Hasan Hüseyin Arslan, Hamdi Tasli, Süleyman Cebeci, Mustafa Gerek
OBJECTIVE: Osteoma is the most common benign tumor of the paranasal sinuses. The clinical characteristics and treatment of this disease remain controversial. The aim of this study is to determine the appropriate method of treatment approach according to the features of osteomas. METHODS: Forty-one patients with paranasal sinus osteomas were included in the study. According to the location and the size of tumors, patients were followed up or operated. Surgical treatment was performed via external, endoscopic, or combined approaches for symptomatic patients...
January 5, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28050414/radiological-study-of-maxillary-sinus-using-cbct-relationship-between-mucosal-thickening-and-common-anatomic-variants-in-chronic-rhinosinusitis
#8
Marco Capelli, Patrizia Gatti
INTRODUCTION: Inflammatory diseases of the maxillary sinus favour the thickening of the sinus mucosa. Therefore, it might be possible to establish a radiological, pathological threshold of mucosal thickening. Furthermore, there is an association between common anatomic variants of the nose and maxillary mucosal thickening. AIM: To define the pathological thickening of maxillary sinus mucosa and its association with the presence of common anatomic variants (concha bullosa, Haller's cell and accessory maxillary ostium)...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28043642/-maxillary-trigeminal-schwannoma-presentation-of-a-case-and-review-of-literature
#9
Alejandro Jacob Madrid-Sánchez, Carlos Castillo-Rangel, Myriam Leticia Contreras-Ayala, Edgardo Ruiz-García, Ana Karen Castillo-Castro, Ricardo Ramírez-Aguilar
INTRODUCTION: Schwannomas are benign tumours that are relatively common in the head, however the involvement of the sinunasal region is rare and there are only 5 cases reported in the maxilla in current literature, representing less than 1% of bone tumours. CLINICAL CASE: We report the case of a woman with a right maxillary schwannoma who underwent a complete resection of the lesion. Emphasis is placed on the rarity of the lesion in terms of its location and includes a review of clinical behaviour, diagnosis and current treatment options...
December 30, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28042629/the-effects-of-gender-and-age-on-forensic-personal-identification-from-frontal-sinus-in-a-turkish-population
#10
Ertugrul Tatlisumak, Mahmut Asirdizer, Aydin Bora, Yavuz Hekimoglu, Yasin Etli, Orhan Gumus, Siddik Keskin
To define the dimensions of the frontal sinus in groups standardized for age and gender and to discuss the reasons and the effects of the variations. Methods: Frontal sinus measurements were obtained from paranasal CTscans of 180 males and 180 females in the Radiology Department of Dursun Odabas Medical Center of Yuzuncu Yil University, Van, which is located in Eastern Turkey, between February and March 2016. The width and height of sinuses were measured on a coronal plane, and the anteroposterior length was measured on an axial plane...
January 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28042527/pediatric-rhinosinusitis
#11
Dana T Badr, Jonathan M Gaffin, Wanda Phipatanakul
Rhinosinusitis, is defined as an inflammation of the paranasal and nasal sinus mucosae. Chronic rhinosinusitis (CRS)is a common problem in the pediatric age group and the diagnosis and treatment are challenging due to the chronicity and similarity of symptoms with allergic rhinitis and adenoid hypertrophy. Although it is less common than acute rhinosinusitis, CRS is becoming more frequent and significantly affects the quality of life in children and can substantially impair daily function. CRS is characterized by sinus symptoms lasting more than 3 months despite medical therapy...
September 2016: Current Treatment Options in Allergy
https://www.readbyqxmd.com/read/28039178/the-natural-history-and-patterns-of-metastases-from-mucosal-melanoma-an-analysis-of-706-prospectively-followed-patients
#12
B Lian, C L Cui, L Zhou, X Song, X S Zhang, D Wu, L Si, Z H Chi, X N Sheng, L L Mao, X Wang, B X Tang, X Q Yan, Y Kong, J Dai, S M Li, X Bai, N Zheng, Charles M Balch, J Guo
BACKGROUND: We examined whether mucosal melanomas are different in their clinical course and patterns of metastases when arising from different anatomic sites. Our hypothesis was that metastatic behavior would differ from primary mucosal melanomas at different anatomical sites. PATIENTS AND METHODS: Clinical and pathological data from 706 patients were compared for their stage distribution, patterns of metastases, CKIT/BRAF mutation status, and overall survival for different anatomical sites...
December 29, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28035526/auditory-changes-in-acromegaly
#13
S Tabur, H Korkmaz, E Baysal, E Hatipoglu, I Aytac, E Akarsu
OBJECTIVE: The aim of this study is to determine the changes involving auditory system in cases with acromegaly. MATERIALS AND METHODS: Otological examinations of 41 cases with acromegaly (uncontrolled n = 22, controlled n = 19) were compared with those of age and gender-matched 24 healthy subjects. Whereas the cases with acromegaly underwent examination with pure tone audiometry (PTA), speech audiometry for speech discrimination (SD), tympanometry, stapedius reflex evaluation and otoacoustic emission tests, the control group did only have otological examination and PTA...
December 29, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28032937/prognostic-value-of-pretreatment-peripheral-blood-markers-in-paranasal-sinus-cancer-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratio
#14
Mario Turri-Zanoni, Giovanni Salzano, Alessia Lambertoni, Marta Giovannardi, Apostolos Karligkiotis, Paolo Battaglia, Paolo Castelnuovo
BACKGROUND: Pretreatment hematological markers have emerged as prognostic factors for several cancers. The purpose of this study was to present our investigation of the value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting recurrence and mortality for patients with primary sinonasal cancers (SNCs). METHODS: We carried out a retrospective review of patients with SNC who had been treated using endoscopic approaches from 2002 to 2014 at a single institute...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28032679/acr-appropriateness-criteria-%C3%A2-nasal-cavity-and-paranasal-sinus-cancers
#15
Farzan Siddiqui, Richard V Smith, Sue S Yom, Jonathan J Beitler, Paul M Busse, Jay S Cooper, Ehab Y Hanna, Christopher U Jones, Shlomo A Koyfman, Harry Quon, John A Ridge, Nabil F Saba, Francis Worden, Min Yao, Joseph K Salama
The American College of Radiology (ACR) Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer-reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28032289/sinonasal-renal-cell-like-carcinoma-case-report-and-review-of-the-literature
#16
Mark Kubik, Nicholas Barasch, Garret Choby, Raja Seethala, Carl Snyderman
The differential diagnosis for clear cell neoplasms of the sinonasal tract is wide but critical to understand. In this paper, we describe a case of renal cell-like adenocarcinoma (SNRCLA) presenting as a paranasal sinus mass with clear cell morphology. The relevant literature is reviewed and the workup for clear cell neoplasms described. SNRCLA is a rarely encountered low grade glandular malignancy of the paranasal sinuses. Despite its morphologic mimicry of renal cell carcinoma, SNRCLA demonstrates a seromucinous phenotype and is associated with a favorable prognosis and low recurrence rates after surgical resection...
December 28, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/28027832/analysis-of-the-factors-affecting-outcome-after-combat-related-cranial-defect-reconstruction
#17
Goran Pavlićević, Milan Lepić, Predrag Perić, Dražen Ivetić, Ana Roganović, Zoran Roganović
INTRODUCTION: Reports on the outcomes of cranioplasty after combat-related injuries are relatively rare in the current literature. We present our results on the reconstruction of cranial defects resulting from injuries sustained in combat, comparing outcomes using autologous (iliac bone) grafts or (acrylate) allografts, and analysis of other factors that may influence the final outcome. MATERIAL AND METHODS: The study comprised 207 patients with cranial defects resulting from combat-related injuries, repaired with autografts or allografts...
December 1, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28019044/severity-of-nasal-inflammatory-disease-questionnaire-for-canine-idiopathic-rhinitis-control-instrument-development-and-initial-validity-evidence
#18
L M Greene, K D Royal, J M Bradley, B D X Lascelles, L R Johnson, E C Hawkins
BACKGROUND: Effective treatments are needed for idiopathic chronic rhinitis in dogs, but assessment of efficacy requires a practical, quantifiable method for assessing severity of disease. OBJECTIVES: To develop and perform initial validity and reliability testing of an owner-completed questionnaire for assessing clinical signs and dog and owner quality of life (QOL) in canine chronic rhinitis. ANIMALS: Twenty-two dogs with histopathologically confirmed chronic rhinitis and 72 healthy dogs...
December 25, 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28010942/syndrome-of-inappropriate-antidiuretic-hormone-secretion-in-a-case-of-olfactory-neuroblastoma-without-anti-diuretic-hormone-immunoreactivity-a-case-report-and-review-of-the-literature
#19
Takafumi Nakano, Junichi Motoshita, Fumi Sawada, Midori Okabe, Akihiro Tamae, Shinsuke Hiramatsu, Satoru Kodama, Hideki Shiratsuchi, Ryuji Yasumatsu, Torahiko Nakashima, Takashi Nakagawa
Olfactory neuroblastoma (ONB) is a relatively rare nasal or paranasal malignant tumor. This tumor is rarely accompanied by paraneoplastic syndromes such as syndrome of inappropriate antidiuretic hormone secretion (SIADH). Here, we report a 31-year-old female with histologically confirmed ONB who had been diagnosed with SIADH three years prior. She was treated with surgery followed by concurrent chemoradiotherapy. SIADH resolved immediately after surgical tumor resection. Immunohistochemically, both biopsy and resected specimens from the nasal cavity had been negative for ADH...
December 20, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28005828/evaluation-of-eyeball-and-orbit-in-relation-to-gender-and-age
#20
Cenk Murat Özer, Ibrahim Ilker Öz, Ismail Şerifoğlu, Mustafa Çağatay Büyükuysal, Çağatay Barut
The orbital aperture is the entrance to the orbit in which most important visual structures such as the eyeball and the optic nerve are found. It is vital not only for the visual system but also for the evaluation and recognition of the face. Eyeball volume is essential for diagnosing microphthalmos or buphthalmos in several eye disorders. Knowing the length of the optic nerve is necessary in selecting the right instruments for enucleation. Therefore, the aim of this study was to evaluate eyeball volume, orbital aperture, and optic nerve dimensions for a morphological description in a Turkish population sample according to gender and body side...
November 2016: Journal of Craniofacial Surgery
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