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https://www.readbyqxmd.com/read/28935549/mini-pterional-and-supraorbital-keyhole-craniotomies-for-ruptured-anterior-circulation-aneurysms-experience-at-a-single-center
#1
Hoanh Tra, Trong Huynh, Ba Nguyen
A keyhole craniotomy is a type of pterional craniotomy that involves a minimally invasive approach for the treatment of cerebral aneurysms. Currently, the mini-pterional keyhole craniotomy (MPKC) and supraorbital keyhole craniotomy (SOKC) procedures are frequently performed. We evaluated the feasibility and safety of SOKCs and MPKCs for the clipping of ruptured intracranial aneurysms in the anterior cerebral circulation as an alternative to the pterional approach in a consecutive series of 25 patients. The rate of intraoperative aneurysmal rupture was 8% (2/25), and all ruptures were safely controlled...
September 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28929274/minimally-invasive-posterior-cervical-foraminotomy-for-treatment-of-radiculopathy-an-effective-time-tested-and-cost-efficient-motion-preservation-technique
#2
REVIEW
L Papavero, R Kothe
OBJECTIVE: To relieve foraminal root impingement due to lateral soft disc fragments, bony spurs, or other rarer causes. INDICATIONS: Soft disc fragment whose bulk is >2/3 lateral to the lateral border of the thecal sac. Intraforaminal dorsal bony narrowing of the root canal. Intraforaminal synovial cyst, extra/intradural tumor. CONTRAINDICATIONS: Paramedian and median soft/hard disc protrusions. Kyphosis of the index level. SURGICAL TECHNIQUE: Patient prone in reverse Trendelenburg position with the head fixed in a Mayfield clamp...
September 19, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28927909/monolateral-pterional-keyhole-approaches-to-bilateral-cerebral-aneurysms-anatomy-and-clinical-application
#3
Liang-Hong Yu, Huang-Cheng Shang-Guan, Guo-Rong Chen, Shu-Fa Zheng, Yuan-Xiang Lin, Zhang-Ya Lin, Pei-Sen Yao, De-Zhi Kang
OBJECTIVE: To study the anatomy and clinical application of monolateral pterional keyhole approach for treating bilateral cerebral aneurysms. MATHERIAL AND METHODS: 12 alcohol-preserved cadaveric heads underwent right pterional keyhole approaches for management of simulative contralateral aneurysms. Length of the contralateral middle cerebral artery (MCA), distal internal carotid artery (DICA), anterior cerebral artery (ACA), and ophthalmic segment of internal carotid artery (OICA) was recorded...
September 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28927224/supraorbital-keyhole-craniotomy-for-basilar-artery-aneurysms-accounting-for-the-cliff-effect
#4
Melissa M Stamates, Andrew K Wong, Anita Bhansali, Ricky H Wong
BACKGROUND: Treatment of basilar artery aneurysms is challenging. While endovascular techniques have dominated, there still remain circumstances where open surgical clipping is required or preferred. Minimally invasive "keyhole" approaches are being used more frequently to provide the durability of surgical clipping with a lower morbidity profile; however, careful patient selection is required. The supraorbital "keyhole" approach has been described for the treatment of basilar artery aneurysms, but careful assessment of the basilar exposure is necessary to ensure proper visualization of the aneurysm and ability to obtain proximal vascular control...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28922894/minimally-invasive-middle-fossa-keyhole-craniectomy-for-repair-of-superior-semicircular-canal-dehiscence
#5
(no author information available yet)
No abstract text is available yet for this article.
October 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28916434/effects-of-icos-t-cell-depletion-via-afucosylated-monoclonal-antibody-medi-570-on-pregnant-cynomolgus-monkeys-and-the-developing-offspring
#6
Simone M Nicholson, Gianluca Carlesso, Lily I Cheng, Halie Cook, Karma DaCosta, Joel Leininger, Kathleen McKeever, Stephen Weasel Scott, Devon Taylor, Katie Streicher, Steve Eck, Molly Reed, Raffaella Faggioni, Ronald Herbst, Rakesh Dixit, Patricia C Ryan
MEDI-570 is a fully human afucosylated monoclonal antibody (MAb) against Inducible T-cell costimulator (ICOS), highly expressed on CD4+ T follicular helper (TFH) cells. Effects of MEDI-570 were evaluated in an enhanced pre-postnatal development toxicity (ePPND) study in cynomolgus monkeys. Administration to pregnant monkeys did cause any abortifacient effects. Changes in hematology and peripheral blood T lymphocyte subsets in maternal animals and infants and the attenuated infant IgG immune response to keyhole limpet hemocyanin (KLH) were attributed to MEDI-570 pharmacology...
September 12, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28904906/a-step-by-step-guide-to-office-based-sperm-retrieval-for-obstructive-azoospermia
#7
REVIEW
Robert M Coward, Jesse N Mills
A variety of surgical options exists for sperm retrieval in the setting of obstructive azoospermia (OA). With appropriate preparation, the majority of these techniques can safely be performed in the office with local anesthesia and with or without monitored anesthesia care (MAC). The available techniques include percutaneous options such as percutaneous epididymal sperm aspiration (PESA) and testicular sperm aspiration (TESA), as well as open techniques that include testicular sperm extraction (TESE) and microsurgical epididymal sperm aspiration (MESA)...
August 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28900154/synthesis-and-evaluation-of-gm2-monophosphoryl-lipid-a-conjugate-as-a-fully-synthetic-self-adjuvant-cancer-vaccine
#8
Zhifang Zhou, Satadru S Mandal, Guochao Liao, Jiatong Guo, Zhongwu Guo
An efficient method was developed for the synthesis of a GM2 derivative suitable for the conjugation with various biomolecules. This GM2 derivative was covalently linked to keyhole limpet hemocyanin (KLH) and monophosphoryl lipid A (MPLA) to form novel therapeutic cancer vaccines. Immunological evaluations of the resultant conjugates in mice revealed that they elicited robust GM2-specific overall and IgG antibody responses. Moreover, the GM2-MPLA conjugate was disclosed to elicit strong immune responses without the use of an adjuvant, proving its self-adjuvant property...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899835/successful-treatment-by-microvascular-decompression-surgery-of-a-patient-with-hemiparesis-due-to-vertebral-artery-compression-of-the-medulla-oblongata-a-case-report-and-literature-review
#9
Jibin Ren, Hongtao Sun, Yunfeng Diao, Xuegang Niu, Hang Wang, Zhengjun Wei, Fei Yuan
Little literature is available on hemiparesis caused by vascular medullary compression, which may occur as a result of dolichoectasia of the vertebrobasilar arterial system. In this paper, we report a case of vertebral artery compression of the medulla oblongata in a 67-year old woman. The patient was hypertensive and developed hemiparesis and intermittent spasms for five years, which became worsened for one year. Cranial nerve MRI showed compression of the medulla oblongata by the left vertebral artery. Motor evoked potential (MEP) examination showed abnormal conduction of MEPs of bilateral toe abductors...
September 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28898778/effects-of-imidacloprid-on-rana-catesbeiana-immune-and-nervous-system
#10
Francesca M Rios, Travis E Wilcoxen, Laura M Zimmerman
Imidacloprid (IMD), a neonicotinoid, is generally considered to be of low toxicity in vertebrates. However, the inhibition of acetylcholine (ACh) receptors can have a profound effect on both the immune and nervous system due to the anti-inflammatory effects of ACh. Vertebrates, such as amphibians, might be affected by IMD because they breed in wetlands where the concentration of IMD is high. In our study, we experimentally exposed Rana catesbeiana tadpoles to environmentally relevant IMD and then quantified the ACh and antibody to non-replicating antigens...
August 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/28882360/local-parastomal-hernia-repair-with-biological-mesh-is-safe-and-effective
#11
Theadore Hufford, Jean-Francois Tremblay, Mohammad Taha Mustafa Sheikh, Slawomir Marecik, John Park, Ina Zamfirova, Kunal Kochar
PURPOSE: The goal of this study was to evaluate the efficacy, morbidity and safety of local parastomal hernia repair using biological mesh. PATIENTS AND METHODS: A retrospective analysis of a prospectively maintained database was performed for parastomal hernia repairs. All patients who underwent local parastomal hernia repair with biological mesh between July 2006 and July 2015 were included in the study. Non-local (laparoscopic or midline incision) procedures were excluded...
August 5, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28867323/endoscopic-middle-cranial-fossa-reconstruction-via-a-subtemporal-keyhole-a-technical-note
#12
Fuminari Komatsu, Masaaki Imai, Akihiro Hirayama, Naokazu Hayashi, Shinri Oda, Masami Shimoda, Mitsunori Matsumae
BACKGROUND: Skull base reconstruction is an essential technique for repairing cerebrospinal fluid (CSF) leakage. A reliable method for middle cranial fossa (MCF) reconstruction with minimal invasiveness has not been reported. An initial case of endoscopic MCF reconstruction via a subtemporal keyhole is described. CASE DESCRIPTION: A 57-year-old man developed severe meningitis and was diagnosed with spontaneous CSF leakage from bone defects on the tegmen tympani...
August 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28866277/evaluation-of-antibody-response-to-an-adjuvanted-hapten-protein-vaccine-as-a-potential-inhibitor-of-sexual-maturation-for-farmed-atlantic-salmon
#13
Darcy S O Mora, Mo D Salman, Christopher A Myrick, Jack C Rhyan, Lowell A Miller, Ellen Marie Sætre, Douglas C Eckery
An experimental contraceptive vaccine was evaluated in Atlantic salmon (Salmo salar). A peptide derived from the beta subunit of luteinizing hormone (LH) was conjugated to two different carrier proteins, bovine serum albumin (BSA) and keyhole limpet hemocyanin (KLH), and formulated with one of four immunostimulants in a water-in-oil emulsion. Specific antibody responses to the peptide and each carrier protein were evaluated. While the antibody response to KLH was stronger than the response to BSA, both carrier proteins stimulated comparable antibody responses to the LH peptide...
August 30, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28865408/peptide-based-vaccines-derived-from-fc%C3%AE%C2%B5ri-beta-subunit-can-reduce-allergic-response-in-mice-model
#14
Ahad Zare, Ali Akbar Pourfathollah, Zahra Pourpak, Janos Szebeni, Seyed Mohammad Reza Ghaffari, Gholam Ali Kardar
Current therapeutic approaches in allergic diseases especially asthma generally focus on using immunological strategies. According to the importance of FceRI in controlling allergic response we used two extracellular regions of Fc epsilon receptor I (FceRI) beta subunit peptides to design two peptide-based vaccines. Probably these peptides vaccines by triggering the immune response to FceRI can reduce the allergic symptoms through blocking the IgE specific receptor. Two extracellular parts of FceRI beta subunit were made by peptide synthesizer and conjugated with keyhole limpet Hemocyanin...
August 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28844742/the-oxygen-binding-properties-of-hemocyanin-from-the-mollusk-concholepas-concholepas
#15
Andrea González, Esteban Nova, Miguel Del Campo, Augusto Manubens, Alfredo De Ioannes, Jorge Ferreira, María Inés Becker
Hemocyanins have highly conserved copper-containing active sites that bind oxygen. However, structural differences among the hemocyanins of various mollusks may affect their physicochemical properties. Here, we studied the oxygen-binding cooperativity and affinity of Concholepas concholepas hemocyanin (CCH) and its two isolated subunits over a wide range of temperatures and pH values. Considering the differences in the quaternary structures of CCH and keyhole limpet hemocyanin (KLH), we hypothesized that the heterodidecameric CCH has different oxygen-binding parameters than the homodidecameric KLH...
August 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28844499/rindopepimut-with-temozolomide-for-patients-with-newly-diagnosed-egfrviii-expressing-glioblastoma-act-iv-a-randomised-double-blind-international-phase-3-trial
#16
Michael Weller, Nicholas Butowski, David D Tran, Lawrence D Recht, Michael Lim, Hal Hirte, Lynn Ashby, Laszlo Mechtler, Samuel A Goldlust, Fabio Iwamoto, Jan Drappatz, Donald M O'Rourke, Mark Wong, Mark G Hamilton, Gaetano Finocchiaro, James Perry, Wolfgang Wick, Jennifer Green, Yi He, Christopher D Turner, Michael J Yellin, Tibor Keler, Thomas A Davis, Roger Stupp, John H Sampson
BACKGROUND: Rindopepimut (also known as CDX-110), a vaccine targeting the EGFR deletion mutation EGFRvIII, consists of an EGFRvIII-specific peptide conjugated to keyhole limpet haemocyanin. In the ACT IV study, we aimed to assess whether or not the addition of rindopepimut to standard chemotherapy is able to improve survival in patients with EGFRvIII-positive glioblastoma. METHODS: In this randomised, double-blind, phase 3 trial, we recruited patients aged 18 years and older with glioblastoma from 165 hospitals in 22 countries...
August 22, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28841120/endoscopic-extradural-supraorbital-approach-to-the-temporal-pole-and-adjacent-area-technical-note
#17
Fuminari Komatsu, Masaaki Imai, Hideaki Shigematsu, Rie Aoki, Shinri Oda, Masami Shimoda, Mitsunori Matsumae
The authors' initial experience with the endoscopic extradural supraorbital approach to the temporal pole and adjacent area is reported. Fully endoscopic surgery using the extradural space via a supraorbital keyhole was performed for tumors in or around the temporal pole, including temporal pole cavernous angioma, sphenoid ridge meningioma, and cavernous sinus pituitary adenoma, mainly using 4-mm, 0° and 30° endoscopes and single-shaft instruments. After making a supraorbital keyhole, a 4-mm, 30° endoscope was advanced into the extradural space of the anterior cranial fossa during lifting of the dura mater...
August 25, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28822400/open-retromuscular-repair-of-parastomal-hernias-with-synthetic-mesh
#18
Lucas R Beffa, Jeremy A Warren, William S Cobb, Bryan Knoedler, Joseph A Ewing, Alfredo M Carbonell
Parastomal hernias (PHs) cause significant morbidity in patients with permanent ostomies, and several laparoscopic and open repair techniques have been described. We report our experience with open retromuscular repair of PHs using permanent synthetic mesh. A prospectively maintained database was retrospectively reviewed to identify patients undergoing PH repair. Primary outcomes are surgical site occurrence, surgical site infection (SSI), and hernia recurrence. Variables were analyzed using Pearson's χ2 test or Fisher's exact test...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28822396/an-evaluation-of-parastomal-hernia-repair-using-the-americas-hernia-society-quality-collaborative
#19
MULTICENTER STUDY
Sarah S Fox, Randy Janczyk, Jeremy A Warren, Alfredo M Carbonell, Benjamin K Poulose, Michael J Rosen, William W Hope
The purpose of this review was to evaluate outcomes relating to parastomal hernia repair. Data from the Americas Hernia Society Quality Collaborative were used to identify patients undergoing parastomal hernia repair from 2013 to 2016. Parastomal hernia repairs were compared with other repairs using Pearson's test and Wilcoxon test with a P value <0.05 considered significant. Parastomal hernia repairs were performed in 311 patients. Techniques of repair include open in 85 per cent and laparoscopic in 15 per cent...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28820930/comparison-of-minimally-invasive-strabismus-surgery-miss-and-conventional-strabismus-surgery-using-the-limbal-approach
#20
Poonam Gupta, Subhash Dadeya, Kamlesh, Vishaal Bhambhawani
PURPOSE: To compare minimally invasive strabismus surgery (MISS) with conventional strabismus surgery for horizontal recti in terms of functional outcome and complications. METHODS: A total of 40 patients requiring surgery for horizontal recti were divided into two groups: those undergoing MISS and those operated on using the conventional limbal technique. In the MISS group, two small keyhole radial cuts were made superior and inferior to the insertion of the muscle margin...
July 1, 2017: Journal of Pediatric Ophthalmology and Strabismus
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