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https://www.readbyqxmd.com/read/29770422/biodegradable-toughened-nanohybrid-shape-memory-polymer-for-smart-biomedical-applications
#1
Arpan Biswas, Akhand Pratap Singh, Dipak Rana, Vinod K Aswal, Pralay Maiti
A polyurethane nanohybrid has been prepared through the in situ polymerization of an aliphatic diisocyanate, ester polyol and a chain extender in the presence of two-dimensional platelets. Polymerization within the platelet galleries helps to intercalate, generate diverse nanostructure and improve the nano to macro scale self-assembly, which leads to a significant enhancement in the toughness and thermal stability of the nanohybrid in comparison to pure polyurethane. The extensive interactions, the reason for property enhancement, between nanoplatelets and polymer chains are revealed through spectroscopic measurements and thermal studies...
May 17, 2018: Nanoscale
https://www.readbyqxmd.com/read/29746276/deepithelialized-skin-reduction-preserves-skin-and-nipple-perfusion-in-immediate-reconstruction-of-large-and-ptotic-breasts
#2
Danielle H Rochlin, Dung H Nguyen
BACKGROUND: Women with large and/or ptotic breasts are often not considered candidates for nipple-sparing mastectomy (NSM) and/or immediate breast reconstruction given difficulties avoiding ischemic complications and achieving a favorable aesthetic result. We report a novel technique involving deepithelialized skin reduction to simultaneously reduce the skin envelope and preserve perfusion to the skin and nipple in immediate breast reconstruction for women that fit this high-risk anatomic profile...
April 30, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29737389/4d-asl-based-mr-angiography-for-visualization-of-distal-arteries-and-leptomeningeal-collateral-vessels-in-moyamoya-disease-a-comparison-of-techniques
#3
Osamu Togao, Akio Hiwatashi, Makoto Obara, Koji Yamashita, Daichi Momosaka, Ataru Nishimura, Koichi Arimura, Nobuhiro Hata, Koji Yoshimoto, Koji Iihara, Marc Van Cauteren, Hiroshi Honda
OBJECTIVES: To evaluate the performance of four-dimensional pseudo-continuous arterial spin labeling (4D-pCASL)-based angiography using CENTRA-keyhole and view sharing (4D-PACK) in the visualization of flow dynamics in distal cerebral arteries and leptomeningeal anastomosis (LMA) collaterals in moyamoya disease in comparison with contrast inherent inflow-enhanced multiphase angiography (CINEMA), with reference to digital subtraction angiography (DSA). METHODS: Thirty-two cerebral hemispheres from 19 patients with moyamoya disease (mean age, 29...
May 8, 2018: European Radiology
https://www.readbyqxmd.com/read/29735481/simultaneous-presence-of-non-and-highly-mutated-keyhole-limpet-hemocyanin-klh-specific-plasmablasts-early-after-primary-klh-immunization-suggests-cross-reactive-memory-b-cell-activation
#4
Claudia Giesecke, Tim Meyer, Pawel Durek, Jochen Maul, Jan Preiß, Joannes F M Jacobs, Andreas Thiel, Andreas Radbruch, Reiner Ullrich, Thomas Dörner
There are currently limited insights into the progression of human primary humoral immunity despite numerous studies in experimental models. In this study, we analyzed a primary and related secondary parenteral keyhole limpet hemocyanin (KLH) immunization in five human adults. The primary challenge elicited discordant KLH-specific serum and blood effector B cell responses (i.e., dominant serum KLH-specific IgG and IgM levels versus dominant KLH-specific IgA plasmablast frequencies). Single-cell IgH sequencing revealed early appearance of highly (>15 mutations) mutated circulating KLH-specific plasmablasts 2 wk after primary KLH immunization, with simultaneous KLH-specific plasmablasts carrying non- and low-mutated IgH sequences...
May 7, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29730213/comparative-matched-pair-analysis-of-keyhole-bone-plug-technique-versus-arthroscopic-assisted-pullout-suture-technique-for-lateral-meniscal-allograft-transplantation
#5
Yong Gon Koh, Yong Sang Kim, Oh Ryong Kwon, Dong Beom Heo, Dae Hyun Tak
PURPOSE: To compare the clinical outcomes and meniscal extrusion measured by magnetic resonance imaging (MRI) between the keyhole bone-plug technique and arthroscopic-assisted pullout suture technique in lateral meniscal allograft transplantation (MAT). METHODS: Between October 2009 and February 2015, patients who underwent lateral MAT were retrospectively reviewed. The inclusion criteria were patients with symptomatic knees that had undergone total or subtotal meniscectomy who were treated with lateral MAT with a minimum follow-up period of 2 years...
May 2, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29719216/hybrid-nanoparticle-based-nicotine-nanovaccines-boosting-the-immunological-efficacy-by-conjugation-of-potent-carrier-proteins
#6
Zongmin Zhao, Yun Hu, Theresa Harmon, Paul R Pentel, Marion Ehrich, Chenming Zhang
A series of hybrid nanoparticle-based nicotine nanovaccines (NanoNicVac) were engineered in this work by conjugating potent carrier protein candidates (Keyhole limpet hemocyanin (KLH) multimer, KLH subunit, cross reactive material 197 (CRM197 ), or tetanus toxoid (TT)) for enhanced immunological efficacy. NanoNicVac with CRM197 or TT were processed by dendritic cells more efficiently than that with KLH multimer or subunit. NanoNicVac carrying CRM197 or TT exhibited a significantly higher immunogenicity against nicotine and a considerably lower immunogenicity against carrier proteins than NanoNicVac carrying KLH multimer or subunit in mice...
April 29, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29687086/vertical-diplopia-and-oscillopsia-due-to-midbrain-keyhole-aqueduct-syndrome-associated-with-severe-cough
#7
Angela Jinsook Oh, Bryan Alexander Lanzman, Yaping Joyce Liao
Purpose: Midline structural defects in the neural axis can give rise to neuro-ophthalmic symptoms. We report a rare case of keyhole aqueduct syndrome presenting after two years of severe cough due to gastroesophageal reflux disease. Observations: A 58-year-old woman with a 2-year history of daily, severe cough presented to the neuro-ophthalmology clinic with progressive diplopia and oscillopsia. Examination revealed a 1-2 Hz down-beating nystagmus in primary gaze that worsened with left, right, and down gazes...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29676694/keyhole-strategy-aiming-at-minimizing-hospital-stay-for-surgical-clipping-of-unruptured-middle-cerebral-artery-aneurysms
#8
Kentaro Mori, Kojiro Wada, Naoki Otani, Arata Tomiyama, Terushige Toyooka, Satoru Takeuchi, Takuji Yamamoto, Yasuaki Nakao, Hajime Arai
OBJECTIVE Aneurysms of the middle cerebral artery (MCA) are still most often treated by clipping through standard craniotomy, but a longer hospital stay is one of the main drawbacks of this treatment. The authors developed a pterional keyhole clipping strategy for unruptured MCA aneurysms with the intention of minimizing hospital stay. In this paper, they report on their experience with this approach and analyze the long-term neurological and radiological outcomes. METHODS A total of 160 relatively small unruptured MCA aneurysms (mean 6...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29606040/decision-making-algorithm-for-minimally-invasive-approaches-to-anterior-skull-base-meningiomas
#9
Malte Ottenhausen, Kavelin Rumalla, Andrew F Alalade, Prakash Nair, Emanuele La Corte, Iyan Younus, Jonathan A Forbes, Atef Ben Nsir, Matei A Banu, Apostolos John Tsiouris, Theodore H Schwartz
OBJECTIVE Anterior skull base meningiomas are benign lesions that cause neurological symptoms through mass effect on adjacent neurovascular structures. While traditional transcranial approaches have proven to be effective at removing these tumors, minimally invasive approaches that involve using an endoscope offer the possibility of reducing brain and nerve retraction, minimizing incision size, and speeding patient recovery; however, appropriate case selection and results in large series are lacking. METHODS The authors developed an algorithm for selecting a supraorbital keyhole minicraniotomy (SKM) for olfactory groove meningiomas or an expanded endoscopic endonasal approach (EEA) for tuberculum sella (TS) or planum sphenoidale (PS) meningiomas based on the presence or absence of olfaction and the anatomical extent of the tumor...
April 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29582804/laparoscopic-repair-for-parastomal-hernia-with-ongoing-barbed-suture-followed-by-sandwich-technique-sandwich-plus-technique
#10
Reiko Wiessner, Thomas Vorwerk, Alexander Gehring
The incidence of parastomal hernias after a permanent stoma is between 50% and 80% depending on the type of stoma, the definition of the hernia (clinical or radiological), and the length of the follow-up. Surgical therapy is complex and involves several techniques with different recurrence rates. We present three cases where we have closed the hernia gap with continuous, non-resorbable, self-retaining sutures with subsequent use of the sandwich technique ('Sandwich-plus-technique'). There were pronounced parastomal hernias in three female patients (mean age was 72 years and the range was 63-78 years) with permanent colostomata...
March 23, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29577957/aluminum-is-a-powerful-adjuvant-in-teleost-fish-despite-failing-to-induce-interleukin-1%C3%AE-release
#11
Diego Angosto, Azucena López-Muñoz, Alicia García-Alcazar, José Meseguer, María P Sepulcre, Victoriano Mulero
Although Aluminum salts (Alum) have been extensively used in human vaccination for decades, its mechanism of action is controversial. In fish, the use of Alum as a vaccine adjuvant is scarce and there are no studies aimed at identifying its mechanism of action. In the present study we report that Alum is a powerful adjuvant in the gilthead seabream (Sparus aurata L., Sparidae) and the European seabass (Dicentrarchus labrax L. Moronidae). Thus, Alum increased the specific antibody titers to the model antigen keyhole limpet hemocyanin as the commonly used Freund's adjuvant did in both species...
March 22, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29571153/tangential-cranial-ballistic-impact-an-illustration-of-the-limitations-of-post-mortem-ct-scan
#12
Clémence Delteil, Pierre Gach, Noura Ben Nejma, Françoise Capasso, Pierre Perich, Pierre Massiani, Guillaume Gorincour, Marie-Dominique Piercecchi-Marti, Lucille Tuchtan
Post-mortem imaging has become more frequently used in forensic procedures, notably in a ballistic context. Despite many advances in this field, the interpretation of computed tomography (CT) can be a very complex matter. Our case illustrates the difficulties of interpretation after quasi-tangential cranial ballistic impact and keyhole wounds. These wounds are difficult to visualize on CT and are among the factors complicating the precise determination of ballistics. These sources of error remind us that CT findings must be interpreted in close comparison with autopsy findings...
March 17, 2018: Legal Medicine
https://www.readbyqxmd.com/read/29569913/development-of-polyclonal-antibodies-for-detection-of-diosbulbin-b-derived-cis-enedial-protein-adducts
#13
Zixia Hu, Shenzhi Zhou, Na Zhang, Weiwei Li, Dongju Lin, Ying Peng, Jiang Zheng
Diosbulbin B (DSB), a major component found in herbal medicine Dioscorea bulbifera L. (DB), can be metabolized to an electrophilic intermediate, DSB-derived cis-enedial (DDE). DDE was suggested to contribute to the hepatotoxicity observed in experimental animals and human after exposure to DSB. Our previous work found that DDE reacted with primary amino and/or sulfhydryl groups of hepatic protein. The objective of the study was to develop polyclonal antibodies which can recognize DDE-derived protein adducts...
March 23, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29562625/looking-through-the-keyhole-exploring-realities-and-possibilities-for-school-breakfast-programs-in-rural-western-australia
#14
Simon O Ichumar, Emma E Dahlberg, Ellen B Paynter, Fiona M C Lucey, Miranda R Chester, Lennelle Papertalk, Sandra C Thompson
OBJECTIVE: To assess the school breakfast program (SBP) in two schools with high Aboriginal student populations in rural Western Australia, their contribution to holistic support, nutritional health education and possibilities for improvement. METHODS: The operations and functioning of one regional and one remote SBP were assessed by stakeholder inquiry related to process and challenges, observations and documentary review. An intervention to increase health education, social interaction and learning about nutrition and food origins implemented in one school was assessed...
March 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29551883/biologic-keyhole-mesh-in-hiatal-hernia-repair
#15
Jeffrey R Watkins, Michael S Truitt, Houssam Osman, Rohan D Jeyarajah
Background and Objectives: Laparoscopic paraesophageal hernia repair (LPEHR) is the new standard, but the use of mesh is still debated. Biologic mesh has shown great promise, but only the U-shaped onlay has been extensively studied. Postoperative dysphagia has historically been a concern with the use of synthetic keyhole mesh and subsequently slowed its adoption. The purpose of our study was to identify the incidence of postoperative dysphagia in a series of patients who underwent laparoscopic paraesophageal hernia repair with novel placement of keyhole biologic mesh...
January 2018: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/29535720/t-cell-specific-loss-of-the-pi-3-kinase-p110%C3%AE-catalytic-subunit-results-in-enhanced-cytokine-production-and-antitumor-response
#16
Laura Aragoneses-Fenoll, Gloria Ojeda, María Montes-Casado, Yeny Acosta-Ampudia, Umberto Dianzani, Pilar Portolés, José M Rojo
Class IA phosphatidylinositol 3-kinase (PI3K) catalytic subunits p110α and p110δ are targets in cancer therapy expressed at high levels in T lymphocytes. The role of p110δ PI3K in normal or pathological immune responses is well established, yet the importance of p110α subunits in T cell-dependent immune responses is not clear. To address this problem, mice with p110α conditionally deleted in CD4+ and CD8+ T lymphocytes (p110α-/- ΔT) were used. p110α-/- ΔT mice show normal development of T cell subsets, but slightly reduced numbers of CD4+ T cells in the spleen...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29529831/dynamic-balance-of-heat-and-mass-in-high-power-density-laser-welding
#17
Hongze Wang, Motoki Nakanishi, Yosuke Kawahito
An experimental system to observe the inner phenomenon of keyhole and molten pool through glass plate by high speed camera and spectrometer in high power density laser welding was set up. Two circular flows in the molten pool were observed by high speed camera, which transferred the mass from the front to the rear of the keyhole to keep the mass balance. Temperature distribution in the molten pool was firstly detected by spectrometer, which indicated that the circular flows acted as the cooling system to take heat away from the keyhole...
March 5, 2018: Optics Express
https://www.readbyqxmd.com/read/29524730/antitumor-activity-and-carrier-properties-of-novel-hemocyanins-coupled-to-a-mimotope-of-gd2-ganglioside
#18
Miriam Palacios, Ricardo Tampe, Miguel Del Campo, Ta-Ying Zhong, Mercedes N López, Flavio Salazar-Onfray, María Inés Becker
Conjugation to carrier proteins is a way to improve the immunogenicity of peptides. Such is the case for peptides mimicking carbohydrate tumor-associated antigens in cancer vaccine development. The most used protein for this purpose is the keyhole limpet hemocyanin (KLH) from Megathura crenulata. Its limited bioavailability has prompted interest in finding new candidates; nevertheless, it is not known whether other hemocyanins might be equally efficient as carrier of carbohydrate peptide mimotopes to promotes anti-tumor responses...
April 25, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29510253/aluminum-adjuvant-potentiates-gilthead-seabream-immune-responses-but-induces-toxicity-in-splenic-melanomacrophage-centers
#19
Jorge Galindo-Villegas, Alicia García-Alcazar, José Meseguer, Victoriano Mulero
A key goal of a successful vaccine formulation is the strong induction of persistent protective immune responses without producing side-effects. Adjuvants have been proved to be successful in several species at inducing increased immune responses against poorly immunogenic antigens. Fish are not the exception and promising results of adjuvanted vaccine formulations in many species are needed. In this study, over a period of 300 days, we characterized the apparent damage and immune response in gilthead seabream immunized by intraperitoneal injection with the model antigen keyhole limpet hemocyanin (KLH) alone or formulated with Montanide ISA water-in-oil (761 or 763), or Imject™ aluminum hydroxide (aluminium), as adjuvants...
March 3, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29499860/parastomal-hernia-repair-using-the-top-hat-technique-an-initial-experience-in-30-patients-at-memorial-sloan-kettering-cancer-center
#20
Michael J Fitzgerald, Sarah Ullrich, Kumar Singh, Oren Misholy, Peter Kingham, Mary S Brady
Parastomal hernia repair remains a significant surgical challenge. Recurrence after standard "keyhole" or primary suture repair is common. We adopted and modified a new technique using a construct shaped like an inverted top hat. We review our experience over the last six years in the first 30 patients (31 consecutive procedures). Of these 31 procedures, six (19%) resulted in a parastomal hernia recurrence with a median follow-up of 31 months (range 0.5-80). Four of the recurrences occurred in our initial experience, when we constructed the top hat of xenograft alone...
February 22, 2018: American Journal of Surgery
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