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https://www.readbyqxmd.com/read/28323640/a-micro-scale-printable-nanoclip-for-electrical-stimulation-and-recording-in-small-nerves
#1
Charles A Lissandrello, Winthrop F Gillis, Jun Shen, Ben W Pearre, Flavia Vitale, Matteo Pasquali, Bradley J Holinski, Daniel J Chew, Alice E White, Timothy J Gardner
OBJECTIVE: The vision of bioelectronic medicine is to treat disease by modulating the signaling of visceral nerves near various end organs. In small animal models, the nerves of interest can have small diameters and limited surgical access. New high-resolution methods for building nerve interfaces are desirable. In this study, we present a novel nerve interface and demonstrate its use for stimulation and recording in small nerves. APPROACH: We design and fabricate micro-scale electrode-laden nanoclips capable of interfacing with nerves as small as 50 µm in diameter...
March 21, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28319826/oil-based-adjuvants-delivered-intradermally-induce-high-primary-igg2-immune-response-in-swine
#2
Zrinka Oreskovic, Hana Kudlackova, Josef Krejci, Katerina Nechvatalova, Martin Faldyna
The effects of intradermal application of antigen with or without different adjuvants and activation of immune response are presented in this study. Six groups of six piglets each were immunized with keyhole limpet haemocyanin (KLH) antigen in combination with aluminium hydroxide or oil-based adjuvants (complete and incomplete Freund's adjuvants, Montanide ISA 206 and Emulsigen). IgG1 and IgG2 levels in sera were measured by KLH-specific ELISA. Interestingly, oil-based adjuvants induced high primary IgG2 response, suggesting the Th1 lymphocyte polarization...
March 11, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28304187/letter-to-the-editor-keyhole-and-standard-subtemporal-approaches
#3
Melissa M Stamates, Ricky H Wong
No abstract text is available yet for this article.
March 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28299251/minimally-invasive-endoscopic-computer-assisted-surgery-technique-and-review
#4
REVIEW
Anand Kumar, Nirma Yadav, Shipra Singh, Neha Chauhan
Endoscopic or minimally invasive surgery popular as keyhole surgery is a medical procedure in which endoscope (a camera) is used, and it has gained broad acceptance with popularity in several surgical specialties and has heightened the standard of care. Oral and maxillofacial surgery is a modern discipline in the field of dentistry in which endoscopy has developed as well as widely used in surgeries and is rapidly gaining importance. The use of different visual as well as standard instruments such as laparoscopic and endoscopic instruments, and high-powered magnification devices, has allowed physicians to decrease the morbidity of many surgical procedures by eliminating the need for a large surgical incision...
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28295752/synthesis-of-an-%C3%AE-2%C3%A2-8-s-linked-gd3-antigen-and-evaluation-of-the-immunogenicity-of-its-glycoconjugate
#5
Chun-Cheng Lin, Ting-Chun Kuan, Hsin-Ru Wu, Avijit K Adak, Ben-Yuan Li, Chien-Fu Liang, Shih-Pin Chiou, Jung-Tung Hung Hung, Alice L Yu Yu, Jih Ru Hwu
Replacing the interglycosidic oxygen atom with a nonhydrolyzable sulfur atom has attracted significant interest because it provides opportunities for developing new glycoconjugate vaccines. Herein, a stereocontrolled and highly convergent method for synthesizing a non-reducing end, inter-S-glycosidic variant of the GD3 (α(2→8)-S-linked GD3) antigen, capable of being resistant to enzymatic hydrolysis was reported. The key steps in the synthesis involved a regio- and stereoselective α(2→3) sialylation of a lactoside acceptor with a C8-iodide-derivatized sialyl donor, followed by an anomeric S-alkylation, which enabled the construction of a terminal S-linked α(2→8) disialyl residue in a stereoselective manner...
March 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28286504/molluskan-hemocyanins-activate-the-classical-pathway-of-the-human-complement-system-through-natural-antibodies
#6
Javier Pizarro-Bauerle, Ismael Maldonado, Eduardo Sosoniuk-Roche, Gerardo Vallejos, Mercedes N López, Flavio Salazar-Onfray, Lorena Aguilar-Guzmán, Carolina Valck, Arturo Ferreira, María Inés Becker
Molluskan hemocyanins are enormous oxygen-carrier glycoproteins that show remarkable immunostimulatory properties when inoculated in mammals, such as the generation of high levels of antibodies, a strong cellular reaction, and generation of non-specific antitumor immune responses in some types of cancer, particularly for superficial bladder cancer. These proteins have the ability to bias the immune response toward a Th1 phenotype. However, despite all their current uses with beneficial clinical outcomes, a clear mechanism explaining these properties is not available...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28284581/cognitive-function-surrounding-resection-of-nonfunctioning-pituitary-adenomas-with-suprasellar-extension-a-prospective-matched-control-study
#7
Philipp Hendrix, Christoph J Griessenauer, Elisa Hans, Andreas Simgen, Joachim Oertel, Julia Karbach
OBJECTIVE: Patients suffering from pituitary adenomas may experience cognitive dysfunctions due to hormonal imbalance or suprasellar tumor extension displacing neural structures. Progressively enlarging or symptomatic nonfunctioning pituitary adenomas with suprasellar extension are frequently resected. The literature on neurocognitive performance surrounding resection of these lesions is sparse. METHODS: A prospective matched-control study was conducted to investigate the impact of nonfunctioning pituitary adenomas with suprasellar extension on preoperative and postoperative cognitive performance...
March 8, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28281548/structure-and-assembly-of-scalable-porous-protein-cages
#8
Eita Sasaki, Daniel Böhringer, Michiel van de Waterbeemd, Marc Leibundgut, Reinhard Zschoche, Albert J R Heck, Nenad Ban, Donald Hilvert
Proteins that self-assemble into regular shell-like polyhedra are useful, both in nature and in the laboratory, as molecular containers. Here we describe cryo-electron microscopy (EM) structures of two versatile encapsulation systems that exploit engineered electrostatic interactions for cargo loading. We show that increasing the number of negative charges on the lumenal surface of lumazine synthase, a protein that naturally assembles into a ∼1-MDa dodecahedron composed of 12 pentamers, induces stepwise expansion of the native protein shell, giving rise to thermostable ∼3-MDa and ∼6-MDa assemblies containing 180 and 360 subunits, respectively...
March 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28277950/chickadees-faced-with-unpredictable-food-increase-fat-reserves-but-certain-components-of-their-immune-function-decline
#9
Emily A Cornelius, François Vézina, Lyette Regimbald, Fanny Hallot, Magali Petit, Oliver P Love, William H Karasov
In winter, temperate resident birds are often faced with periodic low natural food availability. This reduction or unpredictability in resource availability might then have a negative impact on immune function, given that immune system support is highly resource dependent. We investigated the balance between energetic and immune management in captive black-capped chickadees (Poecile atricapilus) by manipulating the predictability of resources. The control group received food ad lib. every day, while the experimental group received a reduced amount of food on random days and food ad lib...
March 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28277477/partial-glossectomy-as-an-adjunctive-method-to-ortho-surgical-treatment
#10
Ney Robson Bezerra Ribeiro, Leonardo de Freitas Silva, Heitor Fontes da Silva, Erik Neiva Ribeiro de Carvalho Reis, Jair Queiroz de Oliveira Neto, Raimundo Nonato Maia, Manuel de Jesus Rodrigues Mello
The macroglossia is a rare condition, congenital or acquired, characterized by hypertrophy of the lingual muscles that can cause both aesthetic and functional changes such as mandibular prognathism and malocclusion. Diagnosis is through clinical examination. Treatment consists of excision of part of the tongue and different surgical techniques have been described in the literature. The keyhole lingual resection technique has shown satisfactory results in reducing the volume and preservation of the neurovascular bundles of the tongue...
March 8, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28274208/an-analysis-of-the-effects-of-a-campaign-supporting-use-of-a-health-symbol-on-food-sales-and-shopping-behaviour-of-consumers
#11
Trine Mørk, Klaus G Grunert, Morten Fenger, Hans Jørn Juhl, George Tsalis
BACKGROUND: Since 2009, the green Keyhole symbol has been a joint Nordic initiative for signalling healthfulness of specific food products. In 2014, the Danish Ministry of Food, Agriculture and Fisheries carried out a campaign aimed mainly at men over 35 with a low level of education, encouraging them to use the Keyhole in their shopping process. The objective of the study is to evaluate the campaign by measuring its effect on consumer behaviour in the store. METHODS: The impact of the Keyhole campaign was measured in selected retail stores...
March 9, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28274144/prospect-of-rindopepimut-in-the-treatment-of-glioblastoma
#12
Aladine A Elsamadicy, Pakawat Chongsathidkiet, Rupen Desai, Karolina Woroniecka, S Harrison Farber, Peter E Fecci, John H Sampson
Rindopepimut (CDX-110) is a peptide vaccine that targets epidermal growth factor receptor variant III (EGFRvIII), a tumor-specific epitope expressed in the most common and lethal primary malignant neoplasm of the brain - glioblastoma (GBM). Areas covered: The EGFRvIII mutation introduces an 801 base pair in-frame deletion of the extracellular domain of the transmembrane tyrosine kinase, resulting in constitutive kinase activity, amplification of cell growth, and inhibition of apoptosis. Rindopepimut contains a 14mer amino acid peptide spanning the EGFRvIII mutation site that is conjugated to keyhole limpet hemocyanin (KLH)...
April 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28257078/google-earth-based-visualizations-for-environmental-flows-and-pollutant-dispersion-in-urban-areas
#13
Daoming Liu, Sasa Kenjeres
In the present study, we address the development and application of an efficient tool for conversion of results obtained by an integrated computational fluid dynamics (CFD) and computational reaction dynamics (CRD) approach and their visualization in the Google Earth. We focus on results typical for environmental fluid mechanics studies at a city scale that include characteristic wind flow patterns and dispersion of reactive scalars. This is achieved by developing a code based on the Java language, which converts the typical four-dimensional structure (spatial and temporal dependency) of data results in the Keyhole Markup Language (KML) format...
March 2, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28254536/quantification-of-working-volumes-exposure-and-target-specific-maneuverability-of-the-pterional-craniotomy-and-its-minimally-invasive-variants
#14
Max Jägersberg, Jerermy Brodard, Jimmy Qiu, Alireza Mansouri, Francesco Doglietto, Fred Gentili, Walter Kucharczyk, Jean Fasel, Karl Schaller, Ivan Radovanovic
OBJECTIVE: Quantitative comparison of minimally invasive and standard cranial approaches remains a methodological challenge. The aim of this study was to apply a new digital, navigation-based method to quantify multiple parameters of the pterional, supraorbital, lateral supraorbital and mini-pterional approaches and to describe a target-specific maneuverability score. METHODS: Supraorbital, lateral supraorbital, mini-pterional and standard pterional craniotomies were performed on 8 sides in 4 cadaver heads...
February 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28254535/keyhole-approach-for-clipping-intracranial-aneurysm-comparison-of-supraorbital-and-pterional-keyhole-approach
#15
Qing Lan, Hengzhu Zhang, Qing Zhu, Ailin Chen, Yanming Chen, Liang Xu, Zhongyong Wang, Liqun Yuan, Shihai Liu
OBJECTIVE: The aim of this research was to compare the functional outcome and safety between supraorbital keyhole approach (SKA) and pterional keyhole approach (PKA) for clipping intracranial aneurysms. METHODS: This is a retrospective study involving 318 patients with a total 365 aneurysms who underwent keyhole surgery, comprising 195 cases in SKA group and 123 cases in PKA group. The outcome measures include Glasgow Outcome Scale (GOS), complete clipping rate, adverse events incidence, operation view angle, working distance, and surgical incision condition...
February 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28251554/a-review-of-minimally-invasive-strabismus-surgery-miss-is-this-the-way-forward
#16
REVIEW
Ioannis Asproudis, Nikolaos Kozeis, Andreas Katsanos, Saurabh Jain, Paris G Tranos, Anastasios-Georgios P Konstas
Minimally invasive surgery is rapidly becoming the norm in medicine, as it often leads to better outcomes and earlier rehabilitation. This article reviews the principles and different techniques employed to perform minimally invasive strabismus surgery (MISS). In these techniques, strabismus surgery is performed through keyhole openings, thus reducing the risk of postoperative corneal complications, minimizing postoperative discomfort, and better preserving muscle function. MISS can be used to perform all types of strabismus surgery, namely rectus muscle recessions, resections, plications, reoperations, retroequatorial myopexy, transpositions, oblique muscle recessions, or plications even in the presence of limited motility...
March 1, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28223248/endoscopic-intradural-subtemporal-keyhole-approach-with-neuronavigational-assistance-to-the-suprasellar-petroclival-and-ventrolateral-brainstem-regions-an-anatomic-study
#17
Zhemin Ding, Qing Wang, Xiaojie Lu, Xinwei Qian
OBJECTIVE: The purposes of this study were to evaluate the feasibility of a purely endoscopic intradural approach to the suprasellar, petroclival and ventrolateral brainstem regions through a subtemporal keyhole and to assess the value of neuronavigational assistance in the Kawase approach. METHODS: Twenty endoscopic intradural subtemporal keyhole approaches were performed on 10 cadaveric heads. An intradural Kawase approach and a navigation-assisted intradural Kawase approach were then carried out on a random side of each specimen...
February 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28216398/engaging-in-a-keyhole-concept-for-the-management-of-ruptured-and-unruptured-aneurysms
#18
Daniel D Cavalcanti, Roberto C de Paula, Paula L Alvarenga, Paulo José P da Mata, Paulo Niemeyer Filho
OBJECTIVE: Many new endovascular devices have been used under the guidance of the International Subarachnoid Aneurysm Trial (ISAT). Clipping still offers higher occlusion rates, and its technique continues to evolve, resulting in smaller exposures and reduced manipulation to brain tissue. We sought to evaluate the routine use of the minisphenoidal approach to manage intracranial aneurysms in a high-volume institution. METHODS: We retrospectively reviewed our database of aneurysm patients from October 2013 to May 2016...
February 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28191620/clinical-application-of-scalp-markers-and-three-dimensional-sliced-computer-tomography-reconstructions-of-the-skull-transverse-sigmoid-sinus-groove-in-the-retrosigmoid-approach
#19
Chao Wang, Han Guoqiang, Chao You, Chuangxi Liu
AIM: To explore the clinical value of bone flap creation and the sinus protection in the approach of retrosigmoid keyhole craniotomy with the guidance of three-dimensional (3D) sliced computer tomography (CT) reconstruction of the skull transverse sinus and sigmoid sinus groove. MATERIAL AND METHODS: The scalp tracings of the transverse sinus and sigmoid sinus groove of 108 posterior fossa lesion patients were delineated by gentian violet, which relies on the relationship between its 3D reconstruction location and scalp marker...
January 17, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28188832/experimental-guillain-barre-syndrome-induced-by-immunization-with-gangliosides-keyhole-limpet-hemocyanin-is-required-for-disease-triggering
#20
Samanta C Funes, María Eugenia Chiari, Romina Comín, Fernando J Irazoqui, Gustavo A Nores
An experimental model of Guillain-Barré Syndrome has been established in recent years. Rabbits develop disease upon immunization with a single dose of an emulsion containing bovine brain gangliosides, KLH and complete Freund's adjuvant. Within a period of four to ten weeks after immunization, they began to produce anti-ganglioside IgG-antibodies first, and to show clinical signs of neuropathy afterwards. In addition to gangliosides, KLH is a requirement for antibody production and disease triggering. Although KLH is commonly used as an immunological carrier protein, an anti-KLH-specific immune response was necessary for induction of both events...
February 7, 2017: Biochimica et Biophysica Acta
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