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https://www.readbyqxmd.com/read/27898965/performance-of-pigs-kept-under-different-sanitary-conditions-affected-by-protein-intake-and-amino-acid-supplementation
#1
Y van der Meer, A Lammers, A J M Jansman, M M J A Rijnen, W H Hendriks, W J J Gerrits
There is growing evidence that requirements for particular AA increase when pigs are kept under low sanitary conditions. The extent to which reduction in growth performance is related to these increased requirements is unclear. To evaluate this relationship, an experiment (2 × 2 × 2 factorial arrangement) was performed with 612 male pigs (9 per pen) kept under low sanitary conditions (LSC) or high sanitary conditions (HSC) and offered ad libitum access to either a normal CP concentration diet (NP; 17, 15, and 15% CP for the starter, grower, and finisher phase, respectively) or a low CP concentration diet (LP; 20% CP reduced relative to NP for each phase), each of which containing a basal AA profile (AA-B) or a supplemented AA profile (AA-S)...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27873293/supraorbital-keyhole-microsurgical-fenestration-of-symptomatic-temporal-arachnoid-cysts-in-children-advantages-and-limitations
#2
Sherif Elkheshin, Ahmed Soliman
AIM: To investigate the impact of endoscope assisted microsurgical fenestration of temporal arachnoid cysts, the advantages and limitations of the technique. MATERIAL AND METHODS: Retrospective study including twenty five children of symptomatic temporal arachnoid cysts operated via Eyebrow Supra-Orbital Keyhole Microsurgical Fenestration targeting medial cyst wall, Preoperative MRI brain was done for all patients. RESULTS: Preoperative, clinical presentation included headache (80%), nausea & vomiting (64%), drug resistant epilepsy (52%), macrocephaly (12%) papilledema (28%) motor weakness in the form of right sided hemiparesis (12%) and cranial nerve palsy...
October 14, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27866824/detection-of-her2-overexpressing-cancer-cells-using-keyhole-shaped-chamber-array-employing-a-magnetic-droplet-handling-system
#3
Mina Okochi, Shinji Koike, Masayoshi Tanaka, Hiroyuki Honda
An on-chip gene expression analysis compartmentalized in droplets was developed for detection of cancer cells at a single-cell level. The chip consists of a keyhole-shaped reaction chamber with hydrophobic modification employing a magnetic bead-droplet-handling system with a gate for bead separation. Using three kinds of water-based droplets in oil, a droplet with sample cells, a lysis buffer with magnetic beads, and RT-PCR buffer, parallel magnetic manipulation and fusion of droplets were performed using a magnet-handling device containing small external magnet patterns in an array...
November 11, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27866381/cardiac-magnetic-resonance-imaging-of-patent-ductus-arteriosus-in-three-dogs
#4
Youngjae Lee, Jaihyun Jung, Junyong Park, Jiyoon Jeong, Seokho Jeon, Sunyoung Park, Jinhwa Chang, Ji-Houn Kang, Chulhyun Lee, Dongwoo Chang
Patent ductus arteriosus (PDA) is the most common congenital cardiovascular disorder in dogs and requires an accurate diagnosis for an appropriate treatment. Cardiac MRI (cMRI) has been reported as a method for characterization of canine thoracic vasculature. However, to the authors' knowledge, no published studies describe evaluation of canine PDA through cMRI. Three dogs were selected for this exploratory study. Electrocardiogram gating and breath-hold techniques were performed using a 3T MR scanner. Both black blood imaging and bright blood cine acquisitions were performed...
November 20, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27849166/first-in-human-study-in-healthy-subjects-with-fr104-a-pegylated-monoclonal-antibody-fragment-antagonist-of-cd28
#5
Nicolas Poirier, Gilles Blancho, Maryvonne Hiance, Caroline Mary, Tim Van Assche, Jos Lempoels, Steven Ramael, Weirong Wang, Virginie Thepenier, Cecile Braudeau, Nina Salabert, Regis Josien, Ian Anderson, Ian Gourley, Jean-Paul Soulillou, Didier Coquoz, Bernard Vanhove
FR104 is a monovalent pegylated Fab' Ab, antagonist of CD28, under development for treatment of transplant rejection and autoimmune diseases. In contrast to CD80/86 antagonists (CTLA4-Ig), FR104 selectively blunts CD28 costimulation while sparing CTLA-4 and PD-L1 coinhibitory signals. In the present work, FR104 has been evaluated in a first-in-human study to evaluate the safety, pharmacokinetics, pharmacodynamics, and potency of i.v. administrations in healthy subjects. Sixty-four subjects were randomly assigned to four single ascending dose groups, two double dose groups and four single ascending dose groups challenged with keyhole limpet hemocyanin...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27847568/intradural-procedural-time-to-assess-technical-difficulty-of-superciliary-keyhole-and-pterional-approaches-for-unruptured-middle-cerebral-artery-aneurysms
#6
Yeon-Ju Choi, Wonsoo Son, Ki-Su Park, Jaechan Park
OBJECTIVE: This study used the intradural procedural time to assess the overall technical difficulty involved in surgically clipping an unruptured middle cerebral artery (MCA) aneurysm via a pterional or superciliary approach. The clinical and radiological variables affecting the intradural procedural time were investigated, and the intradural procedural time compared between a superciliary keyhole approach and a pterional approach. METHODS: During a 5.5-year period, patients with a single MCA aneurysm were enrolled in this retrospective study...
November 2016: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27832380/endoscopic-approach-routes-in-the-posterior-fossa-cisterns-through-the-retrosigmoid-keyhole-craniotomy-an-anatomical-study
#7
Peter Kurucz, Gabor Baksa, Lajos Patonay, Firas Thaher, Michael Buchfelder, Oliver Ganslandt
Endoscopy in cerebellopontine angle surgery is an increasingly used technique. Despite of its advantages, the shortcomings arising from the complex anatomy of the posterior fossa are still preventing its widespread use. To overcome these drawbacks, the goal of this study was to define the anatomy of different endoscopic approaches through the retrosigmoid craniotomy and their limitations by surgical windows. Anatomical dissections were performed on 25 fresh human cadavers to describe the main approach-routes...
November 10, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27822175/keyhole-limpet-hemocyanin-induces-innate-immunity-via-syk-and-erk-phosphorylation
#8
Kyoko Yasuda, Hideki Ushio
Hemocyanin is an extracellular respiratory protein containing copper in hemolymph of invertebrates, such as Mollusk and Arthropod. Keyhole limpet hemocyanin (KLH) is one of hemocyanins and has many years of experience for vaccine developments and immunological studies in mammals including human. However, the association between KLH and the immune systems, especially the innate immune systems, remains poorly understood. The aim of this study is to clarify the direct effects of KLH on the innate immune systems...
2016: EXCLI journal
https://www.readbyqxmd.com/read/27801402/-supraorbital-keyhole-craniotomy-in-surgery-of-anterior-circle-of-willis-aneurysms
#9
R S Dzhindzhikhadze, O N Dreval', V A Lazarev, R L Kambiev
The progress in surgical treatment of intracranial aneurysms is based on the introduction of modern minimally invasive techniques. Among the variety of keyhole approaches, supraorbital craniotomy is most often used in surgical treatment of anterior circle of willis aneurysms. The authors present the preliminary results of application of supraorbital keyhole craniotomy for anterior circle of willis aneurysms in 27 patients. Most of the patients had unruptured aneurysms (18 patients). Nine patients had SAH, and 4 of them were operated on in the acute period...
2016: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/27693663/active-immunization-with-the-peptide-epitope-vaccine-a%C3%AE-3-10-klh-induces-a-th2-polarized-anti-a%C3%AE-antibody-response-and-decreases-amyloid-plaques-in-app-ps1-transgenic-mice
#10
Li Ding, Yuan Meng, Hui-Yi Zhang, Wen-Chao Yin, Yi Yan, Yun-Peng Cao
Active amyloid-β (Aβ) immunotherapy is effective in preventing Aβ deposition, facilitating plaque clearance, and improving cognitive functions in mouse models of Alzheimer's disease (AD). Developing a safe and effective AD vaccine requires a delicate balance between inducing adequate humoral immune responses and avoiding T cell-mediated autoimmune responses. In this study, we designed 2 peptide epitope vaccines, Aβ3-10-KLH and 5Aβ3-10, prepared respectively by coupling Aβ3-10 to the immunogenic carrier protein keyhole limpet hemocyanin (KLH) or by joining 5 Aβ3-10 epitopes linearly in tandem...
September 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27686264/single-incision-laparoscopic-appendicectomy-versus-conventional-three-port-laparoscopic-appendicectomy-a-systematic-review-and-meta-analysis
#11
Omar E Aly, Douglas H Black, Haroon Rehman, Irfan Ahmed
BACKGROUND: Appendicectomy is a well-established surgical procedure used in the management of acute appendicitis. The operation can be performed with minimally invasive surgery or as an open procedure. A further development in the minimally invasive appendicectomy technique has been the introduction of single incision laparoscopic surgery (SILA). AIM: To ascertain any differences in outcomes from available trials comparing SILA with conventional multi-incision laparoscopic appendicectomy (CLA)...
October 2, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27679690/magnetic-resonance-angiography-in-the-diagnosis-of-cerebral-arteriovenous-malformation-and-dural-arteriovenous-fistulas-comparison-of-time-resolved-magnetic-resonance-angiography-and-three-dimensional-time-of-flight-magnetic-resonance-angiography
#12
Yu-Ching Cheng, Hung-Chieh Chen, Chen-Hao Wu, Yi-Ying Wu, Ming-His Sun, Wen-Hsien Chen, Jyh-Wen Chai, Clayton Chi-Chang Chen
BACKGROUND: Traditional digital subtraction angiography (DSA) is currently the gold standard diagnostic method for the diagnosis and evaluation of cerebral arteriovenous malformation (AVM) and dural arteriovenous fistulas (dAVF). OBJECTIVES: The aim of this study was to analyze different less invasive magnetic resonance angiography (MRA) images, time-resolved MRA (TR-MRA) and three-dimensional time-of-flight MRA (3D TOF MRA) to identify their diagnostic accuracy and to determine which approach is most similar to DSA...
April 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27663052/keyhole-revascularization-for-treatment-of-coronal-plane-fracture-of-the-lunate-in-kienb%C3%A3-ck-disease
#13
Jouni Havulinna, Jarkko Jokihaara, Pasi Paavilainen, Olli V Leppänen
Coronal plane fracture of lunate in Kienböck disease is a challenging problem with no proven treatment. We present a technique for the treatment. A vascularized bone graft from the distal radius employing the fourth and fifth extracompartmental artery pedicles is used as a mechanical support in order to enable fracture union. The technical pearls and pitfalls are described and a clinical case is presented.
September 20, 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27637556/transcutaneous-immunization-in-auricle-skin-induces-antigen-specific-mucosal-and-systemic-immune-responses-in-balb-c-mice
#14
Hiromi Nagano, Tomohiro Jimura, Miho Nagano, Takao Makise, Keiichi Miyashita, Yuichi Kurono
OBJECTIVE: Transcutaneous immunization (TCI) is a novel route of vaccination through application of a topical vaccine antigen on skin. Phosphorylcholine (PC) is a structural component of a variety of pathogens, and anti-PC immune responses protect mice against invasive bacterial diseases. The purpose of the study was to examine the effect of TCI using PC in back skin or auricle skin in BALB/c mice. METHODS: TCI was performed in BALB/c mice in back skin or auricle skin using PC-keyhole limpet hemocyanin (KLH) plus cholera toxin (CT)...
September 13, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27636184/is-less-always-better-keyhole-and-standard-subtemporal-approaches-evaluation-of-temporal-lobe-retraction-and-surgical-volume-with-and-without-zygomatic-osteotomy-in-a-cadaveric-model
#15
Serdar Ercan, Alba Scerrati, Phengfei Wu, Jun Zhang, Mario Ammirati
OBJECTIVE The subtemporal approach is one of the surgical routes used to reach the interpeduncular fossa. Keyhole subtemporal approaches and zygomatic arch osteotomy have been proposed in an effort to decrease the amount of temporal lobe retraction. However, the effects of these modified subtemporal approaches on temporal lobe retraction have never been objectively validated. METHODS A keyhole and a classic subtemporal craniotomy were executed in 4 fresh-frozen silicone-injected cadaver heads. The target was defined as the area bordered by the superior cerebellar artery, the anterior clinoid process, supraclinoid internal carotid artery, and the posterior cerebral artery...
September 16, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27624963/6-o-branched-oligo-%C3%AE-glucan-based-antifungal-glycoconjugate-vaccines
#16
Guochao Liao, Zhifang Zhou, Jun Liao, Luning Zu, Qiuye Wu, Zhongwu Guo
With the rapid growth in fungal infections and drug-resistant fungal strains, antifungal vaccines have become an especially attractive strategy to tackle this important health problem. β-Glucans, a class of extracellular carbohydrate antigens abundantly and consistently expressed on fungal cell surfaces, are intriguing epitopes for antifungal vaccine development. β-Glucans have a conserved β-1,3-glucan backbone with sporadic β-1,3- or β-1,6-linked short glucans as branches at the 6-O-positions, and the branches may play a critical role in their immunologic functions...
February 12, 2016: ACS Infectious Diseases
https://www.readbyqxmd.com/read/27596750/assessment-of-the-effect-of-short-term-factors-on-surgical-treatments-for-hypertensive-intracerebral-haemorrhage
#17
Ziyu Zhao, Hongying Wang, Zhong Li, Xiaoxi Wang, Wei Zhang, Kang Feng, Jingchun Fan
BACKGROUND: Hypertension is the most common cause of intracerebral haemorrhages (ICHs), yet the short-term impact factors associated with hypertensive intracerebral haemorrhages (HICHs) in patients who undergo different surgical treatments are still unknown. MATERIALS AND METHODS: All consecutive patients with acute HICHs admitted to our hospital from January 2012 to March 2015 were enrolled in the study. Patients were either randomly divided or assigned according to their family's preference into three groups (those undergoing minimally invasive aspiration, keyhole craniotomy or haematoma aspiration with extended pterional and decompressive craniotomy)...
November 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27595274/endoscopic-microvascular-decompression-with-transposition-for-trigeminal-neuralgia-and-hemifacial-spasm-technical-note
#18
Fuminari Komatsu, Masaaki Imai, Akihiro Hirayama, Kazuko Hotta, Naokazu Hayashi, Shinri Oda, Masami Shimoda, Mitsunori Matsumae
Background Endoscopic microvascular decompression (MVD) offers reliable identification of neurovascular conflicts under superb illumination, and it provides minimally invasive surgery for trigeminal neuralgia and hemifacial spasm. Transposition techniques have been reported as a decompression method to prevent adhesion and granuloma formation around decompression sites, providing better surgical outcomes. The feasibility and effects of transposition under endoscopic MVD were evaluated. Material and Methods Fully endoscopic MVD was performed using 4-mm 0- and 30-degree endoscopes...
September 5, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27593818/en-bloc-cervical-laminoplasty-with-preserving-posterior-structure-and-arcocristectomy-in-cervical-spondylotic-myelopathy
#19
Abdulfettah Tümtürk, Ahmet Küçük, Ahmet Menkü, Rahmi Kemal Koç
AIM: We have aimed to evaluate the clinical success of the en bloc laminoplasty and impact of the arcocristectomy on postoperative axial pain of the patients with cervical spondylotic myelopathy (CSM). MATERIAL AND METHODS: A retrospective review of 81 patients with CSM who underwent an en bloc cervical laminoplasty with preserving posterior structure of the cervical spine during the period from 2007 to 2014 was performed. Arcocristectomy was performed if C6-7 level included to surgery...
March 28, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27593778/endoscopic-optic-nerve-decompression-through-supraorbital-keyhole-extradural-approach-a-cadaveric-study
#20
Xiaodong Wang, Wei Wu, Hengzhu Zhang, Qing Lan
AIM: Many approaches for optic nerve decompression have their own advantages and disadvantages. The aim of this study was to perform endoscopic decompression of optic nerve through the supraorbital keyhole and evaluate its feasibility. MATERIAL AND METHODS: Ten adult cadaveric heads were studied using 4-mm, 0- and 30-degree rigid endoscopes to perform the optic nerve decompression through the supraorbital keyhole extradural approach. Furthermore, the relevant measurements about the optic canal were recorded...
November 13, 2015: Turkish Neurosurgery
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