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https://www.readbyqxmd.com/read/28191620/clinical-application-of-scalp-markers-and-three-dimensional-sliced-computer-tomography-reconstructions-of-the-skull-transverse-sigmoid-sinus-groove-in-the-retrosigmoid-approach
#1
Chao Wang, Han Guoqiang, Chao You, Chuangxi Liu
AIM: To explore the clinical value of bone flap creation and the sinus protection in the approach of retrosigmoid keyhole craniotomy with the guidance of three-dimensional (3D) sliced computer tomography (CT) reconstruction of the skull transverse sinus and sigmoid sinus groove. MATERIAL AND METHODS: The scalp tracings of the transverse sinus and sigmoid sinus groove of 108 posterior fossa lesion patients were delineated by gentian violet, which relies on the relationship between its 3D reconstruction location and scalp marker...
January 17, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28188832/experimental-guillain-barre-syndrome-induced-by-immunization-with-gangliosides-keyhole-limpet-hemocyanin-is-required-for-disease-triggering
#2
Samanta C Funes, María Eugenia Chiari, Romina Comín, Fernando J Irazoqui, Gustavo A Nores
An experimental model of Guillain-Barré Syndrome has been established in recent years. Rabbits develop disease upon immunization with a single dose of an emulsion containing bovine brain gangliosides, KLH and complete Freund's adjuvant. Within a period of four to ten weeks after immunization, they began to produce anti-ganglioside IgG-antibodies first, and to show clinical signs of neuropathy afterwards. In addition to gangliosides, KLH is a requirement for antibody production and disease triggering. Although KLH is commonly used as an immunological carrier protein, an anti-KLH-specific immune response was necessary for induction of both events...
February 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28186859/multimodality-imaging-based-evaluation-of-single-lumen-silicone-breast-implants-for-rupture
#3
Stephen J Seiler, Pooja B Sharma, Jody C Hayes, Ramapriya Ganti, Ann R Mootz, Emily D Eads, Sumeet S Teotia, W Phil Evans
Breast implants are frequently encountered on breast imaging studies, and it is essential for any radiologist interpreting these studies to be able to correctly assess implant integrity. Ruptures of silicone gel-filled implants often occur without becoming clinically obvious and are incidentally detected at imaging. Early diagnosis of implant rupture is important because surgical removal of extracapsular silicone in the breast parenchyma and lymphatics is difficult. Conversely, misdiagnosis of rupture may prompt a patient to undergo unnecessary additional surgery to remove the implant...
February 10, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28173472/book-review-principles-and-practice-of-keyhole-brain-surgery
#4
Kenan I Arnautovic, Marko Kovacevic
No abstract text is available yet for this article.
March 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28154456/induction-of-humoral-immune-response-in-piglets-after-perinatal-or-post-weaning-immunization-against-porcine-circovirus-type-2-or-keyhole-limpet-hemocyanin
#5
Jessica Law, Robert McCorkell, Greg Muench, Katherine Wynne-Edwards, Hermann M Schaetzl, Cristina Solis, Narges Nourozieh, Regula Waeckerlin, Michael Eschbaumer, Shawn Horsman, Markus Czub
The objective of this study was to test the hypothesis that porcine circovirus type-2 (PCV2) vaccination is efficacious when administered in the first week of life. Three groups of pigs were vaccinated with Circumvent either early (at the end of week 1), late (at the end of week 4), or not at all. All 3 groups were later challenged intranasally with PCV2 (at the end of week 5). Two other groups were immunized with keyhole limpet hemocyanin (KLH) as a novel antigen at the end of either week 1 or week 4. Weight, PCV2 genome copy number in serum and saliva, anti-KLH antibody titer, and serum PCV2-neutralizing antibodies were measured weekly...
January 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/28153626/contralateral-interlaminar-keyhole-percutaneous-endoscopic-surgery-in-patients-with-unilateral-radiculopathy-technical-notes
#6
Jae Ha Hwang, Cheul Woong Park
OBJECTIVE: Percutaneous endoscopic surgery is increasingly used as an alternative to open microsurgery for treating lumbar spinal diseases. The purpose of this study was to determine the feasibility and efficacy of contralateral keyhole endoscopic surgery (CKES) for treating unilateral radiculopathy. METHODS: We performed percutaneous endoscopic sublaminar decompression via the contralateral interlaminar approach in 14 patients with unilateral radiculopathy. All procedures were performed under epidural anesthesia...
January 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28150720/drivers-of-cape-verde-archipelagic-endemism-in-keyhole-limpets
#7
Regina L Cunha, Jorge M Assis, Celine Madeira, Rui Seabra, Fernando P Lima, Evandro P Lopes, Suzanne T Williams, Rita Castilho
Oceanic archipelagos are the ideal setting for investigating processes that shape species assemblages. Focusing on keyhole limpets, genera Fissurella and Diodora from Cape Verde Islands, we used an integrative approach combining molecular phylogenetics with ocean transport simulations to infer species distribution patterns and analyse connectivity. Dispersal simulations, using pelagic larval duration and ocean currents as proxies, showed a reduced level of connectivity despite short distances between some of the islands...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28144979/organization-of-glomerular-territories-in-the-olfactory-bulb-of-post-embryonic-wild-chinook-salmon-oncorhynchus-tshawytscha
#8
Cory L Ochs, Tina Suntres, Alexandra Zygowska, Trevor Pitcher, Barbara S Zielinski
The post-embryonic odor imprinting paradigm suggests Chinook salmon (Oncorhynchus tshawytscha) acquire memory to stream-specific amino acid olfactory odors prior to emergence as fry. Because effects of olfactory experience on development can be examined by mapping olfactory sensory neurons extending into distinct territories of glomerular neuropil in the olfactory bulb, glomerular patterning from early yolk-sac larva to fry was documented in wild salmonids, a temporal scale not yet thoroughly explored. Labeling olfactory sensory neurons with anti-keyhole limpet hemocyanin (anti-KLH) revealed seven spatially conserved glomerular territories visible at hatch and well established by the late yolk-sac larva developmental stage...
January 31, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28137722/surgeon-faces-trial-for-lying-about-his-experience-in-keyhole-technique
#9
Clare Dyer
No abstract text is available yet for this article.
January 30, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28131595/short-day-length-enhances-physiological-resilience-of-the-immune-system-against-2-deoxy-d-glucose-induced-metabolic-stress-in-a-tropical-seasonal-breeder-funambulus-pennanti
#10
Sameer Gupta, Chandana Haldar
Studies demonstrate the importance of metabolic resources in the regulation of reproduction and immune functions in seasonal breeders. In this regard, the restricted energy availability can be considered as an environmental variable that may act as a seasonal stressor and can lead to compromised immune functions. The present study explored the effect of photoperiodic variation in the regulation of immune function under metabolic stress condition. The T-cell-dependent immune response in a tropical seasonal breeder Funambulus pennanti was studied following the inhibition of cellular glucose utilization with 2-deoxy-d-glucose (2-DG)...
January 26, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28127976/galantamine-has-impact-on-immunity-in-mice-exposed-to-keyhole-limpet-hemocyanin
#11
M Pohanka, J Zakova, J Fusek
OBJECTIVES: In this work, we hypothesized whether galantamine could interact with the cholinergic anti-inflammatory pathway and modulate immunity this way. BACKGROUND: Galantamine is a drug used for the therapy of Alzheimer disease. The drug inhibits enzyme acetylcholinesterase in the central nervous system, which causes better availability of neurotransmitter acetylcholine. METHODS: In the experiment, we immunized BALB/c laboratory mice by keyhole limpet hemocyanin (KLH) in combination with galantamine in a dose 0...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28125913/meniscal-extrusion-does-not-progress-during-the-midterm-follow-up-period-after-lateral-meniscal-transplantation
#12
Nam-Ki Kim, Seong-Il Bin, Jong-Min Kim, Chang-Rack Lee, Jae-Hyan Kim
BACKGROUND: Meniscal extrusion is related to degeneration of the native knee joint. However, the clinical effect of the phenomenon after meniscal allograft transplantation (MAT) has not been clearly identified. Purpose/Hypothesis: The purpose of this study was to evaluate the change in meniscal extrusion in both the coronal and sagittal planes after lateral MAT through the midterm follow-up period. We hypothesized that meniscal extrusion does not progress during the midterm follow-up period...
December 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28111312/dual-channel-endoscopic-indocyanine-green-fluorescence-angiography-for-clipping-of-cerebral-aneurysms
#13
Won-Sang Cho, Jeong Eun Kim, Hyun-Seung Kang, Eun Jin Ha, Minwoong Jung, Choonghee Lee, Il Hyung Shin, Uk Kang
OBJECTIVE: Neuroendoscopy is useful for assessing the status of perforators, parent arteries, and aneurysms beyond the straight line of microscopic view during aneurysm clipping. We aimed to evaluate the clinical usefulness of our endoscopic indocyanine green angiography (eICGA) system, which can simultaneously display both visible light and ICG fluorescent images. METHODS: A total of 16 unruptured aneurysms in 10 patients were surgically clipped via the keyhole approach...
January 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28111220/prophylactic-active-immunization-with-a-novel-epitope-vaccine-improves-cognitive-ability-by-decreasing-amyloid-plaques-and-neuroinflammation-in-app-ps1-transgenic-mice
#14
Li Ding, Yuan Meng, Hui-Yi Zhang, Wen-Chao Yin, Yi Yan, Yun-Peng Cao
Both amyloid-β peptide (Aβ) deposition and neuroinflammation are considered to be early events that play pivotal roles in Alzheimer's disease (AD) pathogenesis and its associated cognitive impairment. Prophylactic anti-Aβ active immunotherapy is a promising therapeutic strategy for AD, if the Aβ-specific autoimmune responses to self T cell epitopes of Aβ can be avoided. This can be achieved by the use of antigen, which contains the B cell epitope of Aβ and excludes the Aβ-specific T cell epitope. In this study, we developed a novel peptide epitope vaccine, Aβ3-10-KLH, by coupling the B cell epitope Aβ3-10 to keyhole limpet hemocyanin (KLH) as the carrier protein, and subcutaneously injected it into 2...
January 19, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28102958/sliding-window-prior-data-assisted-compressed-sensing-for-mri-tracking-of-lung-tumors
#15
Eugene Yip, Jihyun Yun, Keith Wachowicz, Zsolt Gabos, Satyapal Rathee, B G Fallone
PURPOSE: Hybrid magnetic resonance imaging and radiation therapy devices are capable of imaging in real-time to track intrafractional lung tumor motion during radiotherapy. Highly accelerated magnetic resonance (MR) imaging methods can potentially reduce system delay time and/or improves imaging spatial resolution, and provide flexibility in imaging parameters. Prior Data Assisted Compressed Sensing (PDACS) has previously been proposed as an acceleration method that combines the advantages of 2D compressed sensing and the KEYHOLE view-sharing technique...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28078413/establishment-of-a-sandwich-enzyme-linked-immunosorbent-assay-for-specific-detection-of-bacillus-thuringiensis-bt-cry1ab-toxin-utilizing-a-monoclonal-antibody-produced-with-a-novel-hapten-designed-with-molecular-model
#16
Sa Dong, Xiao Zhang, Yuan Liu, Cunzheng Zhang, Yajing Xie, Jianfeng Zhong, Chongxin Xu, Xianjin Liu
Cry1Ab toxin is commonly expressed in genetically modified crops in order to control chewing pests. At present, the detection method with enzyme-linked immunosorbent assay (ELISA) based on monoclonal antibody cannot specifically detect Cry1Ab toxin for Cry1Ab's amino acid sequence and spatial structure are highly similar to Cry1Ac toxin. In this study, based on molecular design, a novel hapten polypeptide was synthesized and conjugated to keyhole limpet hemocyanin (KLH). Then, through animal immunization with this antigen, a monoclonal antibody named 2C12, showing high affinity to Cry1Ab and having no cross reaction with Cry1Ac, was produced...
January 11, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28072740/keyhole-approach-in-the-neuroendoscopic-treatment-for-hydrocephalus
#17
Qiang Cai, Xiangyang Zhang, Long Wang, Shulan Huang, Zhibiao Chen, Qianxue Chen
The aim of the study was to explore keyhole approach and dura suture in the neuroendoscopic treatment for hydrocephalus.Twelve cases of hydrocephalus patients who were treated with neuroendoscope by this approach were analyzed retrospectively from April 2015 to April 2016 in our department. The basic steps of this procedure was using drill and milling cutter to form a small bone flap instead of burr hole, and then making a cruciate incision on the dura. After endoscopic third ventriculostomy or endoscopic third ventriculostomy + ventriculocystostomy finished, dura was sutured and the bone flap was reset...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28070819/inducing-polyclonal-eag1-specific-antibodies-by-vaccination-with-a-linear-epitope-immunogen-and-its-relation-to-breast-tumorigenesis
#18
Zhandong Li, Ketong Zhu, Xin Gong, Steven Vasilescu, Yu Sun, Kaiqing Hong, Hao Li, Lin Li, Yaming Shan
Ether à-go-go 1 (KCNH1, Kv10.1) (Eag1) is a voltage-gated potassium channel, which is commonly overexpressed in tested breast cancer patients. This occurrence makes it a potential molecular marker and a promising tool for breast cancer diagnosis and therapy. In order to explore protective or specific polyclonal antibodies for further research, potential linear epitopes from Eag1 were collected by sequence alignment. The sequence was synthesized and then coupled to the carrier protein keyhole limpet hemocyanin (KLH) for animal immunization...
January 9, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28059648/validation-of-effectiveness-of-keyhole-clipping-in-nonfrail-elderly-patients-with-unruptured-intracranial-aneurysms
#19
Kentaro Mori, Kojiro Wada, Naoki Otani, Arata Tomiyama, Terushige Toyooka, Kazuya Fujii, Kosuke Kumagai, Satoru Takeuchi, Satoshi Tomura, Takuji Yamamoto, Yasuaki Nakao, Hajime Arai
OBJECTIVE Advanced age is known to be associated with a poor prognosis after surgical clipping of unruptured intracranial aneurysms (UIAs). Keyhole clipping techniques have been introduced for less invasive treatment of UIAs. In this study, the authors compared the complications and clinical and radiological outcomes after keyhole clipping between nonfrail elderly patients (≥ 70 years) and nonelderly patients. METHODS Keyhole clipping (either supraorbital or pterional) was performed to treat 260 cases of relatively small (≤ 10 mm) anterior circulation UIAs...
January 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28047532/th-ef-bra-05-a-method%C3%A3-of-near-real-time-4d-mri-using-volumetric-dynamic-keyhole-vdk-in-the-presence-of-respiratory-motion-for-mr-guided-radiotherapy
#20
B Lewis, S Kim, T Kim
PURPOSE: To develop a novel method that enables 4D MR imaging in near real-time for continuous monitoring of tumor motion in MR-guided radiotherapy. METHODS: This method is mainly based on an idea of expanding dynamic keyhole to full volumetric imaging acquisition. In the VDK approach introduced in this study, a library of peripheral volumetric k-space data is generated in given number of phases (5 and 10 in this study) in advance. For 4D MRI at any given time, only volumetric central k-space data are acquired in real-time and combined with pre-acquired peripheral volumetric k-space data in the library corresponding to the respiratory phase (or amplitude)...
June 2016: Medical Physics
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