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https://www.readbyqxmd.com/read/28749850/midline-suboccipital-endoscopic-transcerebellomedullary-fissure-keyhole-approach
#1
Lin Yang, Hengzhu Zhang, Xingdong Wang, Zhengcun Yan, Lang Chen, Xiaoyan Ji, Jun Dong
OBJECTIVE: To study the endoscopic anatomy of the 4th ventricle and lateral brainstem regions via the midline suboccipital endoscopic transcerebellomedullary fissure keyhole approach assisted by a neuronavigation system and discuss the feasibility and indications of this approach. MATERIALS AND METHODS: Craniotomy procedures performed via the midline suboccipital endoscopic transcerebellomedullary fissure keyhole approach were simulated on 8 adult cadaveric heads fixed by formalin, and the related anatomic structures in the 4th ventricles or around the brainstem were observed through the 0° endoscope or alternatively 30° one...
July 26, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28713253/on-the-keyhole-hypothesis-high-mutual-information-between-ear-and-scalp-eeg
#2
Kaare B Mikkelsen, Preben Kidmose, Lars K Hansen
We propose and test the keyhole hypothesis-that measurements from low dimensional EEG, such as ear-EEG reflect a broadly distributed set of neural processes. We formulate the keyhole hypothesis in information theoretical terms. The experimental investigation is based on legacy data consisting of 10 subjects exposed to a battery of stimuli, including alpha-attenuation, auditory onset, and mismatch-negativity responses and a new medium-long EEG experiment involving data acquisition during 13 h. Linear models were estimated to lower bound the scalp-to-ear capacity, i...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28710441/igg3-antigen-complexes-are-deposited-on-follicular-dendritic-cells-in-the-presence-of-c1q-and-c3
#3
Lu Zhang, Zhoujie Ding, Birgitta Heyman
IgG3, passively administered together with small proteins, induces enhanced primary humoral responses against these proteins. We previously found that, within 2 h of immunization, marginal zone (MZ) B cells capture IgG3-antigen complexes and transport them into splenic follicles and that this requires the presence of complement receptors 1 and 2. We have here investigated the localization of IgG3 anti-2, 4, 6-trinitrophenyl (TNP)/biotin-ovalbumin-TNP immune complexes in the follicles and the involvement of classical versus total complement activation in this process...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28705703/a-technique-for-resecting-occipital-pole-gliomas-using-a-keyhole-lobectomy
#4
Andrew K Conner, Cordell M Baker, Robert G Briggs, Joshua D Burks, Chad A Glenn, Adam D Smitherman, Jake P Morgan, Nathan A Pittman, Michael E Sughrue
OBJECTIVE: Our purpose is to describe a method of resecting occipital pole gliomas through a keyhole lobectomy and share the patient outcomes of this technique. METHODS: We performed a retrospective review of data obtained on all patients who underwent resection of occipital pole gliomas by the senior author between 2012 and 2016. We describe our technique for resecting these tumors utilizing a keyhole lobectomy and share the patient outcomes of this operation. RESULTS: Eight patients were included in this study...
July 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28695881/a-case-report-of-modified-laparoscopic-keyhole-plus-repair-for-parastomal-hernia-following-ileal-conduit
#5
S Rajapandian, Samrat V Jankar, Sumanta Dey, Vikram Annamaneni, Sandeep C Sabnis, S Sathiymurthy, R Parthsarathi, P Praveen Raj, P Senthilnathan, C Palanivelu
Parastomal hernia is one of the most common but challenging complication after stoma formation. Modified Sugarbaker technique is the recommended procedure for repair parastomal hernia, however, keyhole repair technique had also been used in certain instances. In cases of parastomal hernia following ileal conduit procedure, the Sugarbaker technique is been described, although with associated theoretical risk of conduit failure. We are reporting a case of post-radical cystectomy with ileal conduit presented with symptomatic large parastomal hernia...
July 7, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28689773/the-toll-like-receptor-ligands-hiltonol-%C3%A2-polyiclc-and-imiquimod-effectively-activate-antigen-specific-immune-responses-in-tasmanian-devils-sarcophilus-harrisii
#6
Amanda L Patchett, Cesar Tovar, Lynn M Corcoran, A Bruce Lyons, Gregory M Woods
Devil facial tumour disease (DFTD) describes two genetically distinct transmissible tumours that pose a significant threat to the survival of the Tasmanian devil. A prophylactic vaccine could protect devils from DFTD transmission. For this vaccine to be effective, potent immune adjuvants will be required. Toll-like receptors (TLRs) promote robust immune responses in human cancer studies and are highly conserved across mammalian species. In this study, we investigated the proficiency of TLR ligands for immune activation in the Tasmanian devil using in vitro mononuclear cell stimulations and in vivo immunisation trials with a model antigen...
July 6, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28686118/method-for-temporal-keyhole-lobectomies-in-resection-of-low-and-high-grade-gliomas
#7
Andrew K Conner, Joshua D Burks, Cordell M Baker, Adam D Smitherman, Dillon P Pryor, Chad A Glenn, Robert G Briggs, Phillip A Bonney, Michael E Sughrue
OBJECTIVE The purpose of this study was to describe a method of resecting temporal gliomas through a keyhole lobectomy and to share the results of using this technique. METHODS The authors performed a retrospective review of data obtained in all patients in whom the senior author performed resection of temporal gliomas between 2012 and 2015. The authors describe their technique for resecting dominant and nondominant gliomas, using both awake and asleep keyhole craniotomy techniques. RESULTS Fifty-two patients were included in the study...
July 7, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28666013/exploitation-rates-of-two-benthic-resources-across-management-regimes-in-central-chile-evidence-of-illegal-fishing-in-artisanal-fisheries-operating-in-open-access-areas
#8
Miguel Andreu-Cazenave, Maria Dulce Subida, Miriam Fernandez
There is an urgent need to quantify the impacts of artisanal fisheries and define management practices that allow for the recovery and conservation of exploited stocks. The extent of illegal catch is particularly critical as a driver of overexploitation in artisanal fisheries. However, the lack of data at proper spatial scales limits the evaluation of illegal fishing and effectiveness of management practices. We used a catch curve analysis to estimate total instantaneous mortality as a proxy of fishing pressure in the artisanal benthic fishery in central Chile...
2017: PloS One
https://www.readbyqxmd.com/read/28652560/zymosan-a-enhances-humoral-immune-responses-to-soluble-protein-in-chickens
#9
Mohamed Fahmy Abou Elazab, Yoshiaki Inoue, Hisakazu Kamei, Hiroyuki Horiuchi, Shuichi Furusawa
Vaccination is the most effective method for controlling the infectious diseases that threaten the poultry industry worldwide. The use of adjuvants or immunostimulants is often necessary to improve vaccine efficacy, particularly for vaccines based on recombinant protein or inactivated pathogens. The adjuvant effects of zymosan A on antigen-specific antibody production were investigated in chickens. First, the optimal adjuvant dose of zymosan A was determined. Chicks were immunized with dinitrophenyl-keyhole limpet hemocyanin (DNP-KLH) at a dosage of 2 mg/kg body weight (BW) with or without zymosan A (at a dosage of 0...
June 23, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28652117/simultaneous-resection-of-multiple-metastatic-brain-tumors-with-multiple-keyhole-craniotomies
#10
Cordell Michael Baker, Chad A Glenn, Robert G Briggs, Josh D Burks, Adam D Smitherman, Andrew K Conner, Allison E Williams, Muhammad U Malik, Ozer Algan, Michael E Sughrue
BACKGROUND: The proper management of symptomatic patients with two or more brain metastases is not entirely clear and the surgical outcomes of these patients undergoing multiple simultaneous craniotomies have not been well described. In this manuscript, we describe patient outcomes after simultaneously resecting metastatic lesions through multiple keyhole craniotomies. METHODS: We conducted a retrospective review of data obtained on all patients undergoing resection of multiple brain metastases in one operation between 2014 and 2016...
June 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28643202/specific-igm-and-regulation-of-antibody-responses
#11
Anna Sörman, Birgitta Heyman
Specific IgM, administered together with the antigen it recognizes, enhances primary antibody responses, formation of germinal centers, and priming for secondary antibody responses. The response to all epitopes on the antigen to which IgM binds is usually enhanced. IgM preferentially enhances responses to large antigens such as erythrocytes, malaria parasites, and keyhole limpet hemocyanine. In order for an effect to be seen, antigens must be administered in suboptimal concentrations and in close temporal relationship to the IgM...
June 23, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28634308/-variations-of-the-endoscopic-keyhole-transcranial-approach
#12
Tadashi Watanabe
No abstract text is available yet for this article.
June 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28620232/real-time-monitoring-of-laser-powder-bed-fusion-process-using-high-speed-x-ray-imaging-and-diffraction
#13
Cang Zhao, Kamel Fezzaa, Ross W Cunningham, Haidan Wen, Francesco De Carlo, Lianyi Chen, Anthony D Rollett, Tao Sun
We employ the high-speed synchrotron hard X-ray imaging and diffraction techniques to monitor the laser powder bed fusion (LPBF) process of Ti-6Al-4V in situ and in real time. We demonstrate that many scientifically and technologically significant phenomena in LPBF, including melt pool dynamics, powder ejection, rapid solidification, and phase transformation, can be probed with unprecedented spatial and temporal resolutions. In particular, the keyhole pore formation is experimentally revealed with high spatial and temporal resolutions...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28617827/nog-hil-4-tg-a-new-humanized-mouse-model-for-producing-tumor-antigen-specific-igg-antibody-by-peptide-vaccination
#14
Yoshie Kametani, Ikumi Katano, Asuka Miyamoto, Yusuke Kikuchi, Ryoji Ito, Yukari Muguruma, Banri Tsuda, Sonoko Habu, Yutaka Tokuda, Kiyoshi Ando, Mamoru Ito
Immunodeficient mice transplanted with human peripheral blood mononuclear cells (PBMCs) are promising tools to evaluate human immune responses to vaccines. However, these mice usually develop severe graft-versus-host disease (GVHD), which makes estimation of antigen-specific IgG production after antigen immunization difficult. To evaluate antigen-specific IgG responses in PBMC-transplanted immunodeficient mice, we developed a novel NOD/Shi-scid-IL2rγnull (NOG) mouse strain that systemically expresses the human IL-4 gene (NOG-hIL-4-Tg)...
2017: PloS One
https://www.readbyqxmd.com/read/28607115/surface-lamp-2-is-an-endocytic-receptor-that-diverts-antigen-internalized-by-human-dendritic-cells-into-highly-immunogenic-exosomes
#15
Dario Armando Leone, Andrea Peschel, Markus Brown, Helga Schachner, Miriam J Ball, Marianna Gyuraszova, Ulrike Salzer-Muhar, Minoru Fukuda, Caterina Vizzardelli, Barbara Bohle, Andrew J Rees, Renate Kain
The lysosome-associated membrane protein (LAMP) family includes the dendritic cell endocytic receptors DC-LAMP and CD68, as well as LAMP-1 and LAMP-2. In this study we identify LAMP-1 (CD107a) and LAMP-2 (CD107b) on the surface of human monocyte-derived dendritic cells (MoDC) and show only LAMP-2 is internalized after ligation by specific Abs, including H4B4, and traffics rapidly but transiently to the MHC class II loading compartment, as does Ag conjugated to H4B4. However, pulsing MoDC with conjugates of primary (keyhole limpet hemocyanin; KLH) and recall (Bet v 1) Ags (H4B4*KLH and H4B4*Bet v 1) induced significantly less CD4 cell proliferation than pulsing with native Ag or Ag conjugated to control mAb (ISO*KLH and ISO*Bet v 1)...
June 12, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28592796/immunochemical-approach-for-monitoring-of-structural-transition-of-apoa-i-upon-hdl-formation-using-novel-monoclonal-antibodies
#16
Hitoshi Kimura, Shiho Mikawa, Chiharu Mizuguchi, Yuki Horie, Izumi Morita, Hiroyuki Oyama, Takashi Ohgita, Kazuchika Nishitsuji, Atsuko Takeuchi, Sissel Lund-Katz, Kenichi Akaji, Norihiro Kobayashi, Hiroyuki Saito
Apolipoprotein A-I (apoA-I) undergoes a large conformational reorganization during remodeling of high-density lipoprotein (HDL) particles. To detect structural transition of apoA-I upon HDL formation, we developed novel monoclonal antibodies (mAbs). Splenocytes from BALB/c mice immunized with a recombinant human apoA-I, with or without conjugation with keyhole limpet hemocyanin, were fused with P3/NS1/1-Ag4-1 myeloma cells. After the HAT-selection and cloning, we established nine hybridoma clones secreting anti-apoA-I mAbs in which four mAbs recognize epitopes on the N-terminal half of apoA-I while the other five mAbs recognize the central region...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28584703/patterns-of-bleaching-and-mortality-following-widespread-warming-events-in-2014-and-2015-at-the-hanauma-bay-nature-preserve-hawai-i
#17
Ku'ulei S Rodgers, Keisha D Bahr, Paul L Jokiel, Angela Richards Donà
Drastic increases in global carbon emissions in the past century have led to elevated sea surface temperatures that negatively affect coral reef organisms. Worldwide coral bleaching-related mortality is increasing and data has shown even isolated and protected reefs are vulnerable to the effects of global climate change. In 2014 and 2015, coral reefs in the main Hawaiian Islands (MHI) suffered up to 90% bleaching, with higher than 50% subsequent mortality in some areas. The location and severity of bleaching and mortality was strongly influenced by the spatial and temporal patterns of elevated seawater temperatures...
2017: PeerJ
https://www.readbyqxmd.com/read/28584424/two-piece-obturator-using-lock-and-key-mechanism
#18
Prema Sukumaran, Michael R Fenlon
This paper describes a method used for the fabrication of a two-piece denture obturator for a patient who had surgical removal of the premaxilla due to squamous cell carcinoma. The patient had been wearing a two-piece obturator but encountered difficulty in inserting the prosthesis. In this case report, a lock-and-key mechanism was used to easily assemble the two-piece prosthesis intraorally. A keyhole was designed on the obturator to act as the lock while the denture was used as the key that fitted into the keyhole...
April 2017: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/28577919/immunization-of-tg-appswe-psen1de9-mice-with-a%C3%AE-3-10-klh-vaccine-prevents-synaptic-deficits-of-alzheimer-s-disease
#19
Yuan Meng, Li Ding, HuiYi Zhang, WenChao Yin, Yi Yan, YunPeng Cao
The amyloid cascade hypothesis is widely accepted by researchers as the mechanism of Alzheimer's disease. Active immunization to eliminate Aβ depositions has been used in preclinical and clinical studies. Aβ3-10-KLH is a vaccine of the Aβ3-10 peptide combined with keyhole limpet hemocyanin (KLH). We immunized 2.5-month-old Tg-APPswe/PSEN1dE9 mice with Aβ3-10-KLH peptide and Aβ1-42 peptide to eliminate Aβ deposits in the brains of these transgenic mice. The results of immunohistochemical staining and transmission electron microscopy detection indicated that our new vaccine was more advantageous in protecting synaptic function and structure than the Aβ1-42 peptide...
May 31, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28562666/quantitative-analysis-of-the-cd4-t-cell-response-to-therapeutic-antibodies-in-healthy-donors-using-a-novel-t-cell-pbmc-assay
#20
Heidi S Schultz, Stine Louise Reedtz-Runge, B Thomas Bäckström, Kasper Lamberth, Christian R Pedersen, Anne M Kvarnhammar
Many biopharmaceuticals (BPs) are known to be immunogenic in the clinic, which can result in modified pharmacokinetics, reduced efficacy, allergic reactions and anaphylaxis. During recent years, several technologies to predict immunogenicity have been introduced, but the predictive value is still considered low. Thus, there is an unmet medical need for optimization of such technologies. The generation of T cell dependent high affinity anti-drug antibodies plays a key role in clinical immunogenicity. This study aimed at developing and evaluating a novel in vitro T cell:PBMC assay for prediction of the immunogenicity potential of BPs...
2017: PloS One
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