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JOURNAL ARTICLE
Manoj Limbraj Yellurkar, Vani Sai Prasanna, Pamelika Das, Sulogna Sarkar, Rakesh Matta, Devendra Kumar Dhaked, Ramalingam Peraman, Amit Kumar Taraphdar, Satheesh Kumar Nanjappan, Ravichandiran Velayutham, Somasundaram Arumugam
ETHNOPHARMACOLOGICAL RELEVANCE: Nonalcoholic fatty liver disease (NAFLD) is the most common severe liver disease globally, progressing further into nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Vasaguduchyadi Kwatha (VK) is an Ayurvedic formulation traditionally used to treat liver diseases and other metabolic complications. This study is an ethnopharmacological approach to unravel this indigenous remedy. AIM OF THE STUDY: We aimed to discover the probable mechanism of action of VK against NASH in this study, using network pharmacology, molecular docking, in vitro study, and preclinical investigation...
May 23, 2024: Journal of Ethnopharmacology
#22
REVIEW
Ali Benjamin Abbasi, Vincent Wu, Julie E Lang, Laura J Esserman
Outcomes for patients with breast cancer have improved over time due to increased screening and the availability of more effective therapies. It is important to recognize that breast cancer is a heterogeneous disease that requires treatment based on molecular characteristics. Early endpoints such as pathologic complete response correlate with event-free survival, allowing the opportunity to consider de-escalation of certain cancer treatments to avoid overtreatment. This article discusses clinical trials of tailoring treatment (eg, I-SPY2) and screening (eg, WISDOM) to individual patients based on their unique risk features...
April 2024: Surgical Oncology Clinics of North America
#23
JOURNAL ARTICLE
Wenwen Zhou, Xumei Tao, Jie Wang, Bo Shen, Chuanying Huang
OBJECTIVE: Parkinson's disease is a brain disorder that can cause mobility problems as well as mental health, sleep, pain and other health problems. To analyze the establishment of a platform for Parkinson's patients to cooperate with intelligent health education based on behavior change theory and the corresponding nursing measures. METHODS: 80 patients with Parkinson's disease in the Affiliated Brain Hospital of Nanjing Medical University from October 2021 to September 2022 were selected and included in the conventional and wisdom education groups according to different health education methods, with 40 patients in each group...
February 9, 2024: Alternative Therapies in Health and Medicine
#24
JOURNAL ARTICLE
Masaaki Toyoda, Takao Fukuda, Ryota Fujimoto, Kentaro Kawakami, Chikako Hayashi, Yuki Nakao, Yukari Watanabe, Tsukasa Aoki, Miyu Shida, Terukazu Sanui, Masahide Taguchi, Kensuke Yamamichi, Ayami Okabe, Tatsunori Okada, Kyoko Oka, Koichi Nakayama, Fusanori Nishimura, Shunichi Kajioka
INTRODUCTION & OBJECTIVES: Stem cell therapy for regenerative medicine has been sincerely investigated, but not still popular although some clinical trials show hopeful results. This therapy is suggested to be a representative candidate such as bone defect due to the accident, iatrogenic resection oncological tumor, congenital disease, and severe periodontitis in oral region. Recently, the Bio-3D printer "Regenova®" has been introduced as an innovative three-dimensional culture system, equipped scaffold-free bio-assembling techniques without any biomaterials...
July 2024: Biochemistry and Biophysics Reports
#25
JOURNAL ARTICLE
Aasma Shaukat, Jack Wolf, Kyle Ryder, Jennifer P Wisdom, Timothy R Church
No abstract text is available yet for this article.
February 14, 2024: Clinical Gastroenterology and Hepatology
#26
JOURNAL ARTICLE
Limin Zhang, Jianing You, Yiqing Huang, Ruiqi Jing, Yifei He, Yujie Wen, Lulu Zheng, Yong Zhao
BACKGROUND: Dysmenorrhea is one of the most common ailments affecting young and middle-aged women, significantly impacting their quality of life. Traditional Chinese Medicine (TCM) offers unique advantages in treating dysmenorrhea. However, an accurate diagnosis is essential to ensure correct treatment. This research integrates the age-old wisdom of TCM with modern Machine Learning (ML) techniques to enhance the precision and efficiency of dysmenorrhea syndrome differentiation, a pivotal process in TCM diagnostics and treatment planning...
February 13, 2024: Combinatorial Chemistry & High Throughput Screening
#27
JOURNAL ARTICLE
Elham Torof, Edward Newton, Hana Morrissey, Patrick A Ball
AIM: This survey was conducted to determine the type and frequency of antibiotics (AB) use for the prevention of infections in dental third molar (M3) extraction and implantation procedures (DIP) among UK dentists and the opinions underpinning their practice. METHODS AND DESIGN: Systematic reviews of the evidence were undertaken alongside this survey of practicing dentists in the United Kingdom to identify the opinions and practices of those undertaking the procedures...
January 2024: Medicine and pharmacy reports
#28
JOURNAL ARTICLE
Souvik Ghosh, Viney Kumar, Haimanti Mukherjee, Saakshi Saini, Sumeet Gupta, Samrat Chauhan, Komal Kushwaha, Debrupa Lahiri, Debabrata Sircar, Partha Roy
ETHNOPHARMACOLOGICAL RELEVANCE: This study has important ethnopharmacological implications since it systematically investigated the therapeutic potential of Bacopa monnieri (L.) Wettst. (Brahmi) in treating neurological disorders characterized by oxidative stress-a growing issue in the aging population. Bacopa monnieri, which is strongly rooted in Ayurveda, has long been recognized for its neuroprotective and cognitive advantages. The study goes beyond conventional wisdom by delving into the molecular complexities of Bacopa monnieri, particularly its active ingredient, Bacoside-A, in countering oxidative stress...
February 8, 2024: Journal of Ethnopharmacology
#29
JOURNAL ARTICLE
Abheek Raviprasad, Kevin Pierre, Dahyun Kang, Jordan Turetsky, Rajvi Thakkar, Bayar Batmunh, Ronald Quisling, John Rees, Linda Lanier, Roberta M Slater, Christopher L Sistrom, Priya G Sharma, Dhanashree A Rajderkar, Anthony A Mancuso
BACKGROUND AND PURPOSE: Suppurative retropharyngeal lymphadenitis is a retropharyngeal space infection almost exclusively seen in the young (4-8 years old) pediatric population. It can be misdiagnosed as a retropharyngeal abscess, leading to unnecessary invasive treatment procedures. This retrospective study aims to assess radiology residents' ability to independently identify CT imaging findings and make a definitive diagnosis of suppurative retropharyngeal lymphadenitis in a simulated call environment...
February 10, 2024: Emergency Radiology
#30
JOURNAL ARTICLE
Rufus O Akinyemi, Hemant K Tiwari, Vinodh Srinivasasainagendra, Onoja Akpa, Fred S Sarfo, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Morenikeji Komolafe, Lukman Owolabi, Godwin O Osaigbovo, Olga A Mamaeva, Brian A Halloran, Joshua Akinyemi, Daniel Lackland, Olugbo Y Obiabo, Taofik Sunmonu, Innocent I Chukwuonye, Oyedunni Arulogun, Carolyn Jenkins, Abiodun Adeoye, Atinuke Agunloye, Okechukwu S Ogah, Godwin Ogbole, Adekunle Fakunle, Ezinne Uvere, Motunrayo M Coker, Akinkunmi Okekunle, Osahon Asowata, Samuel Diala, Mayowa Ogunronbi, Osi Adeleye, Ruth Laryea, Raelle Tagge, Sunday Adeniyi, Nathaniel Adusei, Wisdom Oguike, Paul Olowoyo, Olayinka Adebajo, Abimbola Olalere, Olayinka Oladele, Joseph Yaria, Bimbo Fawale, Philip Ibinaye, Olalekan Oyinloye, Yaw Mensah, Omotola Oladimeji, Josephine Akpalu, Benedict Calys-Tagoe, Hamisu A Dambatta, Adesola Ogunniyi, Rajesh Kalaria, Donna Arnett, Charles Rotimi, Bruce Ovbiagele, Mayowa O Owolabi
BACKGROUND: African ancestry populations have the highest burden of stroke worldwide, yet the genetic basis of stroke in these populations is obscure. The Stroke Investigative Research and Educational Network (SIREN) is a multicenter study involving 16 sites in West Africa. We conducted the first-ever genome-wide association study (GWAS) of stroke in indigenous Africans. METHODS: Cases were consecutively recruited consenting adults (aged > 18 years) with neuroimaging-confirmed ischemic stroke...
February 5, 2024: Genome Medicine
#31
JOURNAL ARTICLE
Yiwen Tian, Yun Shi, Yujie Zhu, Huan Li, Jinyang Shen, Xun Gao, Baochang Cai, Weidong Li, Kunming Qin
The processing of traditional Chinese medicine (TCM) is a unique traditional pharmaceutical technology in China, which is the most important feature that distinguishes Chinese medicine from natural medicine and plant medicine. Since the record in Huangdi Neijing (Inner Canon of the Yellow Emperor), till now, the processing of TCM has experienced more than 2000 years of inheritance, innovation, and development, which is a combination of TCM theory and clinical practice, and plays an extremely important position in the field of TCM...
January 30, 2024: Heliyon
#32
JOURNAL ARTICLE
Vladimir Badmaev
The dynamically evolving science of pharmacology requires AI technology to advance a new path for drug development. The author proposes generative AI for future drugs, identifying suitable drug molecules, uncharacteristically to previous generations of medicines, incorporating the wisdom, experience, and intuit of traditional materia medica and the respective traditional medicine practitioners. This paper describes the guiding principles of the new drug development, springing from the tradition and practice of Tibetan medicine, defined as the Interactive Nutrient Process (INP)...
2024: Drug Design, Development and Therapy
#33
JOURNAL ARTICLE
Rebekah A Hoeks, Michael J Deml, Julie Dubois, Oliver Senn, Sven Streit, Yael Rachamin, Katharina Tabea Jungo
In early 2020, when the first COVID-19 cases were confirmed in Switzerland, the federal government started implementing measures such as national stay-at-home recommendations and a strict limitation of health care services use. General practitioners (GPs) and their at-risk patients faced similar uncertainties and grappled with subsequent sensemaking of the unprecedented situation. Qualitative interviews with 24 GPs and 37 at-risk patients were conducted which were analyzed using thematic analysis. Weick's (1993) four sources of -resilience - improvisation, virtual role systems, attitudes of wisdom and respectful interaction - heuristically guide the exploration of on-the-ground experiences and informal ways GPs and their at-risk patients sought to ensure continuity of primary care...
January 30, 2024: Anthropology & Medicine
#34
JOURNAL ARTICLE
Georgia E Paterson, Felicity J Dickens, Judith A Hurdman, Omar M Pirzada
A man in his 50s, with a history of night sweats and weight loss, presented acutely with dyspnoea and chest pain. Imaging revealed right middle lobe consolidation and a large pericardial effusion. The diagnosis of actinomycosis was made using endobronchial ultrasound-guided sampling from the pericardial effusion. An orthopantomogram demonstrated that the source was a large cavity in the left lower wisdom tooth. This tooth was extracted before the completion of his antibiotic course, and the patient made a full recovery...
January 9, 2024: BMJ Case Reports
#35
JOURNAL ARTICLE
Leonard Knoedler, Michael Alfertshofer, Samuel Knoedler, Cosima C Hoch, Paul F Funk, Sebastian Cotofana, Bhagvat Maheta, Konstantin Frank, Vanessa Brébant, Lukas Prantl, Philipp Lamby
BACKGROUND: The United States Medical Licensing Examination (USMLE) has been critical in medical education since 1992, testing various aspects of a medical student's knowledge and skills through different steps, based on their training level. Artificial intelligence (AI) tools, including chatbots like ChatGPT, are emerging technologies with potential applications in medicine. However, comprehensive studies analyzing ChatGPT's performance on USMLE Step 3 in large-scale scenarios and comparing different versions of ChatGPT are limited...
January 5, 2024: JMIR Medical Education
#36
JOURNAL ARTICLE
Peter D Young, Andrew N Papanikitas, John Spicer
We suggest that in the particular context of medical education, ethics can be considered in a similar way to other kinds of knowledge that are categorised and shaped by academics in the context of wider society. Moreover, the study of medical ethics education is translational in a manner loosely analogous to the study of medical education as adjunct to translational medicine. Some have suggested there is merit in the idea that much as translational research attempts to connect the laboratory scientist's work to its implications for patient care, translational ethics focuses on bringing ethics scholarship into the sphere of personal and public action...
January 5, 2024: Bioethics
#37
REVIEW
Abhijeet Puri, Popat Mohite, Swastika Maitra, Vetriselvan Subramaniyan, Vinoth Kumarasamy, Daniel E Uti, Amany A Sayed, Fatma M El-Demerdash, Mohammad Algahtani, Attalla F El-Kott, Ali A Shati, Mai Albaik, Mohamed M Abdel-Daim, Item J Atangwho
As we navigate the modern era, the intersection of time-honoured natural remedies and contemporary scientific approaches forms a burgeoning frontier in global healthcare. For generations, natural products have been foundational to health solutions, serving as the primary healthcare choice for 80% to 85% of the world's population. These herbal-based, nature-derived substances, significant across diverse geographies, necessitate a renewed emphasis on enhancing their quality, efficacy, and safety. In the current century, the advent of biogenic phytonanoparticles has emerged as an innovative therapeutic conduit, perfectly aligning with principles of environmental safety and scientific ingenuity...
December 31, 2023: Biomedicine & Pharmacotherapy
#38
REVIEW
Osatohanmwen Ekomwereren, Abdullah Shehryar, Noor Abdullah Yahya, Abdur Rehman, Maryam Affaf, Srikar P Chilla, Uday Kumar, Nuzhat Faran, Mohammed Khaleel I K H Almadhoun, Maria Quinn, Chukwuyem Ekhator
Dermatosurgery, a specialized branch within dermatology, has traversed an extraordinary journey through time, shaped by ancient practices, technological leaps, and shifting societal perceptions. This review explores the evolution of dermatosurgery, highlighting its profound transformation from addressing solely medical concerns to seamlessly integrating aesthetics. From its roots in ancient civilizations, where cultural traditions laid the foundation for modern techniques, to the twentieth-century technological renaissance, marked by innovative tools and enhanced understanding of skin anatomy, dermatosurgery has emerged as a dynamic field...
November 2023: Curēus
#39
JOURNAL ARTICLE
C Dayanan, M F Ozupek, N K Seyrek
BACKGROUND AND AIM: The surgical extraction of impacted wisdom teeth is a standard practice in dentistry. Unfortunately, inflammatory reactions such as discomfort, edema, and trismus frequently jeopardize patients' well-being after the extraction of third molars. Saline solutions at room temperature (25°C) are routinely used in impacted tooth extraction. Refrigerated saline solutions were used to work with cold solutions, and as the refrigerator temperature was 4°C, this study was designed to have a cold solution temperature of 4°C...
December 1, 2023: Nigerian Journal of Clinical Practice
#40
JOURNAL ARTICLE
Dona Babu, Sally Marotti, Debra Rowett, Renly Lim, Alice Wisdom, Lisa Kalisch Ellett
The ward round (WR) is an important opportunity for interprofessional interaction and communication enabling optimal patient care. Pharmacists' participation in the interprofessional WR can reduce adverse drug events and improve medication appropriateness and communication. WR participation by clinical pharmacists in Australia is currently limited. This study aims to explore what is impacting clinical pharmacists' participation in WRs in Australian hospitals. A self-administered, anonymous national survey of Australian clinical pharmacists was conducted...
December 27, 2023: Journal of Interprofessional Care
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