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https://www.readbyqxmd.com/read/29414041/wisdom-of-crowds-for-synthetic-accessibility-evaluation
#1
Yukino Baba, Tetsu Isomura, Hisashi Kashima
Synthetic accessibility evaluation is a process to assess the ease of synthesis of compounds. A rapid method for the assessment of synthetic accessibility for a vast number of chemical compounds is expected to bring about a breakthrough in the drug discovery. Although several computational methods have been proposed, the compound evaluation has still been processed by medicinal chemists; however, the low throughput of the human evaluation due to the lack of chemists is a critical issue for handling a large number of compounds...
January 30, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29391049/bone-regeneration-by-human-dental-pulp-stem-cells-using-a-helioxanthin-derivative-and-cell-sheet-technology
#2
Yasuyuki Fujii, Yoko Kawase-Koga, Hironori Hojo, Fumiko Yano, Marika Sato, Ung-Il Chung, Shinsuke Ohba, Daichi Chikazu
BACKGROUND: Human dental pulp stem cells (DPSCs), which have the ability to differentiate into multiple lineages, were recently identified. DPSCs can be collected readily from extracted teeth and are now considered to be a type of mesenchymal stem cell with higher clonogenic and proliferative potential than bone marrow stem cells (BMSCs). Meanwhile, the treatment of severe bone defects, such as fractures, cancers, and congenital abnormalities, remains a great challenge, and novel bone regenerative techniques are highly anticipated...
February 1, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29380213/medical-students-exposure-to-the-humanities-correlates-with-positive-personal-qualities-and-reduced-burnout-a-multi-institutional-u-s-survey
#3
Salvatore Mangione, Chayan Chakraborti, Giuseppe Staltari, Rebecca Harrison, Allan R Tunkel, Kevin T Liou, Elizabeth Cerceo, Megan Voeller, Wendy L Bedwell, Keaton Fletcher, Marc J Kahn
BACKGROUND: Literature, music, theater, and visual arts play an uncertain and limited role in medical education. One of the arguments often advanced in favor of teaching the humanities refers to their capacity to foster traits that not only improve practice, but might also reduce physician burnout-an increasing scourge in today's medicine. Yet, research remains limited. OBJECTIVE: To test the hypothesis that medical students with higher exposure to the humanities would report higher levels of positive physician qualities (e...
January 29, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29366418/ayahuasca-psychological-and-physiologic-effects-pharmacology-and-potential-uses-in-addiction-and-mental-illness
#4
Jonathan Hamill, Jaime Hallak, Serdar M Dursun, Glen Baker
Ayahuasca, a traditional Amazonian decoction with psychoactive properties, is made from bark of the Banisteriopsis caapi vine (contains beta-carboline alkaloids) and leaves of the Psychotria viridis bush (supply the hallucinogen N,N-dimethyltryptamine (DMT)). Originally used by indigenous shamans for the purposes of spirit communication, magical experiences, healing, and religious rituals, across several South American countries ayahuasca has been incorporated into folk medicine and spiritual healing, and several Brazilian churches use it routinely to foster spiritual experience...
January 24, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29332025/prolegomena-to-a-true-integrative-medical-paradigm
#5
Babak Daneshfard, Mohammad Reza Sanaye, Majid Nimrouzi
When a paradigm starts to show signs of failure to cope with significant questions in any basic/applied branch of human knowledge, there come on the scene those who have perused the related literature enough to either answer those major questions according to the established paradigm or proffer a (wholly) new way of looking at things. In the latter case, the history of science tells us, a paradigm shift takes place. Modern medicine cannot be proven to be totally disconnected from its traditional roots. Where traditional medicine came to give its place to present-day conventional medicine, a number of humanistic aspects of healing, in addition to some axioms of old wisdom, were actually lost...
January 15, 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29249635/study-on-physical-properties-of-ayurvedic-nanocrystalline-tamra-bhasma-by-employing-modern-scientific-tools
#6
Rakesh Kr Singh, Sanjay Kumar, Abhay Kr Aman, S M Karim, Sunil Kumar, Manoranjan Kar
BACKGROUND: Tamra Bhasma is derived from metallic copper that is recommended for different ailments of liver and spleen, dropsy, abdominal pain, heart disease, colitis, tumors, anemia, loss of appetite, tuberculosis, as well as eye problems. OBJECTIVES: The knowledge of crystallite size and active ingredients in Bhasma materials is limited restricting its use as nanomedicine in the modern era. Also, the 2015 Nobel prize in medicine has motivated many researchers towards traditional medicines...
December 15, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29235408/balint-work-and-the-creation-of-medical-knowledge
#7
John Muench
Michael Balint's pioneering work in primary care was not simply the application of psychodynamic theory to the complex problems and relationships encountered by clinicians. Rather, Balint's work was part of a wider conversation in Western epistemology that had already begun to break down the enlightenment rationalist agenda. Since the time of Descartes, we sought to find certain truth through decontextualizing and abstracting problems, and through separation of the observer from the thing observed, with a focus on finding universal timeless laws that could be generalized...
January 1, 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29194464/computer-aided-biomarker-discovery-for-precision-medicine-data-resources-models-and-applications
#8
Yuxin Lin, Fuliang Qian, Li Shen, Feifei Chen, Jiajia Chen, Bairong Shen
Biomarkers are a class of measurable and evaluable indicators with the potential to predict disease initiation and progression. In contrast to disease-associated factors, biomarkers hold the promise to capture the changeable signatures of biological states. With methodological advances, computer-aided biomarker discovery has now become a burgeoning paradigm in the field of biomedical science. In recent years, the 'big data' term has accumulated for the systematical investigation of complex biological phenomena and promoted the flourishing of computational methods for systems-level biomarker screening...
November 29, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29175699/-do-it-yourself-vaccine-rejection-and-complementary-and-alternative-medicine-cam
#9
Katie Attwell, Paul R Ward, Samantha B Meyer, Philippa J Rokkas, Julie Leask
In this article, we elucidate a symbiotic relationship between complementary and alternative medicine (CAM) and rejection of, or hesitancy towards, vaccination. In Fremantle, Western Australia, and Adelaide, South Australia, we conducted in-depth interviews from September 2013-December 2015 with 29 parents who had refused or delayed some or all of their children's vaccines. Our qualitative analysis found that for many, their do-it-yourself ethic and personal agency was enhanced by self-directed CAM use, alongside (sometimes informal) CAM practitioner instruction...
November 16, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29152156/revisiting-the-linkage-between-ethnomedical-use-and-development-of-new-medicines-a-novel-plant-collection-strategy-towards-the-discovery-of-anticancer-agents
#10
Joshua M Henkin, Kongmany Sydara, Mouachanh Xayvue, Onevilay Souliya, A Douglas Kinghorn, Joanna E Burdette, Wei-Lun Chen, Bethany G Elkington, Djaja D Soejarto
The Vietnam-Laos International Cooperative Biodiversity Group (ICBG) based at the University of Illinois at Chicago (UIC) catalyzed a country-wide network of medicinal plant preserves (MPP) and medicinal biodiversity preserves (MBP) now established in ten provinces of the Lao People's Democratic Republic (Lao PDR), which are relied upon as protected sources of ethnomedicines for local villagers and traditional healers. In collaboration with the Lao PDR's Institute of Traditional Medicine (ITM), our ongoing P01 Program Project (Ohio State University) examined the anticancer bioprospecting potential for two of the most exhaustively inventoried of these sites: the Bolikhamxay MPP and the Xiengkhouang MBP...
October 2017: Journal of Medicinal Plant Research
https://www.readbyqxmd.com/read/29110730/a-meta-science-for-a-global-bioethics-and-biomedicine
#11
David S Basser
BACKGROUND: As suggested by Shook and Giordano, understanding and therefore addressing the urgent international governance issues around globalizing bio-medical/technology research and applications is limited by the perception of the underlying science. METHODS: A philosophical methodology is used, based on novel and classical philosophical reflection upon existent literature, clinical wisdoms and narrative theory to discover a meta-science and telos of humankind for the development of a relevant and defendable global biomedical bioethics...
November 7, 2017: Philosophy, Ethics, and Humanities in Medicine: PEHM
https://www.readbyqxmd.com/read/29110535/dental-stem-cells-in-tooth-regeneration-and-repair-in-the-future
#12
Christian Morsczeck, Torsten E Reichert
Human dental stem cells can be obtained from postnatal teeth, extracted wisdom teeth or exfoliated deciduous teeth. Due to their differentiation potential, these mesenchymal stem cells are promising for tooth repair. Therefore, the development of dental tissue regeneration represents a suitable but challenging, target for dental stem cell therapies. Areas covered: In this review, the authors provide an overview of human dental stem cells and their properties for regeneration medicine. Numerous preclinical studies have shown that dental stem cells improve bone augmentation and healing of periodontal diseases...
November 7, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29109061/extraction-fractionation-and-re-fractionation-of-artemisia-nilagirica-for-anticancer-activity-and-hplc-esi-qtof-ms-ms-determination
#13
Neha Sahu, Sanjeev Meena, Vijaya Shukla, Priyank Chaturvedi, Brijesh Kumar, Dipak Datta, K R Arya
ETHNOPHARMACOLOGICAL RELEVANCE: Medicinal plants used in traditional medicines are affordable, easily accessible, safer, less toxic and considered as a rich or efficient source of bioactive molecules for modern therapeutics. Artemisia nilagirica (AR) has a long history of use in Indian traditional medicine to combat a wide variety of diseases including cancer. AIM OF THE STUDY: Considering the vast potential of traditional healing plants to deliver safer, less toxic and efficient chemotherapeutics, we have examined anticancer activity of ethanolic extract, bioactive fractions and sub-fractions of AR against different human cancer cell lines along with their phytochemical analysis to understand the insights of novel anticancer activities for further preclinical studies...
November 16, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29058213/how-to-become-a-smart-patient-in-the-era-of-precision-medicine
#14
Yalan Chen, Lan Yang, Hai Hu, Jiajia Chen, Bairong Shen
The objective of this paper is to define the definition of smart patients, summarize the existing foundation, and explore the approaches and system participation model of how to become a smart patient. Here a thorough review of the literature was conducted to make theory derivation processes of the smart patient; "data, information, knowledge, and wisdom (DIKW) framework" was performed to construct the model of how smart patients participate in the medical process. The smart patient can take an active role and fully participate in their own health management; DIKW system model provides a theoretical framework and practical model of smart patients; patient education is the key to the realization of smart patients...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28960730/reasoning-evidence-and-clinical-decision-making-the-great-debate-moves-forward
#15
EDITORIAL
Michael Loughlin, Robyn Bluhm, Stephen Buetow, Kirstin Borgerson, Jonathan Fuller
When the editorial to the first philosophy thematic edition of this journal was published in 2010, critical questioning of underlying assumptions, regarding such crucial issues as clinical decision making, practical reasoning, and the nature of evidence in health care, was still derided by some prominent contributors to the literature on medical practice. Things have changed dramatically. Far from being derided or dismissed as a distraction from practical concerns, the discussion of such fundamental questions, and their implications for matters of practical import, is currently the preoccupation of some of the most influential and insightful contributors to the on-going evidence-based medicine debate...
October 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28944288/the-wisdom-study-breaking-the-deadlock-in-the-breast-cancer-screening-debate
#16
REVIEW
Laura J Esserman
There are few medical issues that have generated as much controversy as screening for breast cancer. In science, controversy often stimulates innovation; however, the intensely divisive debate over mammographic screening has had the opposite effect and has stifled progress. The same two questions-whether it is better to screen annually or bi-annually, and whether women are best served by beginning screening at 40 or some later age-have been debated for 20 years, based on data generated three to four decades ago...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28853524/-cerebral-palsy-at-the-age-of-modern-obstetrics-ancient-beliefs-versus-solid-facts
#17
Shali Mazaki-Tovi
For many decades the conventional wisdom was that the sole etiology for cerebral palsy is difficult delivery. The adverse outcome associated with cerebral palsy was intuitively related to complications during labor. The blame, unjustifiably and recklessly, was placed on devoted physicians and midwifes. This wrongful accusation, that one may describe as "scientific blood libel" is unprecedented in medicine. In his article, Professor Blickstein scrupulously revises the scientific evidence connecting birth asphyxia and cerebral palsy and refutes the common belief that the only cause for cerebral palsy is complicated delivery...
August 2017: Harefuah
https://www.readbyqxmd.com/read/28762222/-smart-medicine-and-healthcare
#18
Yen-Chiao Angel Lu, Li-Chin Chen
Innovation and rapid technological development in Smart Medicine or Smart Healthcare impact profoundly on many aspects of healthcare. It is believed that Health Information Technology (HIT) has the potential to improve integration between care providers, reduce administrative costs and burdens, reduce medical errors, and improve care quality and patient outcomes. However, issues such as interoperability, compatibility, and integration are critical to effectively integrating hardware and software in order to fully realize the benefits of HIT...
August 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/28758992/demystifying-traditional-herbal-medicine-with-modern-approach
#19
Fu-Shuang Li, Jing-Ke Weng
Plants have long been recognized for their therapeutic properties. For centuries, indigenous cultures around the world have used traditional herbal medicine to treat a myriad of maladies. By contrast, the rise of the modern pharmaceutical industry in the past century has been based on exploiting individual active compounds with precise modes of action. This surge has yielded highly effective drugs that are widely used in the clinic, including many plant natural products and analogues derived from these products, but has fallen short of delivering effective cures for complex human diseases with complicated causes, such as cancer, diabetes, autoimmune disorders and degenerative diseases...
July 31, 2017: Nature Plants
https://www.readbyqxmd.com/read/28736906/dental-pulp-stem-cells-and-the-management-of-neurological-diseases-an-update
#20
REVIEW
Ibrahim Mortada, Rola Mortada, Mohamad Al Bazzal
Medical research in regenerative medicine has brought promising perspectives for the use of stem cells in clinical trials. Stem cells are undifferentiated cells capable of multilineage differentiation and available in numerous sources in the human body. Dental pulp constitutes an attractive source of these cells since collecting mesenchymal stem cells from this site is a noninvasive practice that can be performed after a common surgical extraction of supernumerary or wisdom teeth. Thus, tissue sacrifice is very low and several cytotypes can be obtained owing to these cells' multipotency, in addition to the fact that they can be cryopreserved and stored for long periods...
July 24, 2017: Journal of Neuroscience Research
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