keyword
https://read.qxmd.com/read/38520872/resveratrol-protects-against-myocardial-ischemic-injury-in-obese-mice-via-activating-sirt3-foxo3a-signaling-pathway-and-restoring-redox-homeostasis
#1
JOURNAL ARTICLE
Xi Zhu, En Ma, Yixuan Ge, Meng Yuan, Xiaowei Guo, Jun Peng, Weidong Zhu, Dan-Ni Ren, Da Wo
BACKGROUND: Increasing global overweight and obesity rates not only increase the prevalence of myocardial infarction (MI), but also exacerbate ischemic injury and result in worsened prognosis. Currently, there are no drugs that can reverse myocardial damage once MI has occurred, therefore discovering drugs that can potentially limit the extent of ischemic damage to the myocardium is critical. Resveratrol is a polyphenol known for its antioxidant properties, however whether prolonged daily intake of resveratrol during obesity can protect against MI-induced damage remains unexplored...
March 21, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38135396/regulation-of-pm-2-5-on-mitochondrial-damage-in-h9c2-cells-through-mir-421-sirt3-pathway-and-protective-effect-of-mir-421-inhibitor-and-resveratrol
#2
JOURNAL ARTICLE
Shanshan Chen, Wenqi Chen, Zhiping Li, Jianwei Yue, Ken Kin Lam Yung, Ruijin Li
Fine particulate matter (PM2.5 ) exposure is associated with cardiovascular disease (CVD) morbidity and mortality. Mitochondria are sensitive targets of PM2.5 , and mitochondrial dysfunction is closely related to the occurrence of CVD. The epigenetic mechanism of PM2.5 -triggered mitochondrial injury of cardiomyocytes is unclear. This study focused on the miR-421/SIRT3 signaling pathway to investigate the regulatory mechanism in cardiac mitochondrial dynamics imbalance in rat H9c2 cells induced by PM2.5 . Results illustrated that PM2...
April 2024: Journal of Environmental Sciences (China)
https://read.qxmd.com/read/38012584/abnormalities-in-the-sirt1-sirt3-axis-promote-myocardial-ischemia-reperfusion-injury-through-ferroptosis-caused-by-silencing-the-pink1-parkin-signaling-pathway
#3
JOURNAL ARTICLE
Yunfei Liao, Ben Ke, Xiaoyan Long, Jianjun Xu, Yongbing Wu
BACKGROUND: Myocardial ischemia-reperfusion injury (MIRI) is one of the main reasons for poor prognosis in patients with ischemic cardiomyopathy (ICM). To date, the mechanism remains unknown. As members of the silent information regulator 2 (SIR2) family, both SIRT1 and SIRT3 have been shown to play critical roles in protecting cardiomyocytes against MIRI, but their specific protective mechanism, their interact between the two and their relationship with ferroptosis are still unclear...
November 27, 2023: BMC Cardiovascular Disorders
https://read.qxmd.com/read/37858064/resveratrol-reduces-ros-induced-ferroptosis-by-activating-sirt3-and-compensating-the-gsh-gpx4-pathway
#4
JOURNAL ARTICLE
Xingjie Wang, Tianli Shen, Jie Lian, Kai Deng, Chao Qu, Enmeng Li, Gan Li, Yiwei Ren, Zijun Wang, Zhengdong Jiang, Xuejun Sun, Xuqi Li
BACKGROUND: Intestinal ischemia-reperfusion injury occurs in acute intestinal obstruction, intussusception, acute mesenteric artery embolism, and other diseases and can lead to local intestinal necrosis, distant organ involvement, or systemic reactions, with high morbidity and mortality. Ferroptosis plays a crucial role in intestinal ischemia-reperfusion injury, and inhibition of ferroptosis may provide new approaches for treating the disease. SIRT3 protects cells from oxidative stress and may be involved in the process of ferroptosis...
October 19, 2023: Molecular Medicine
https://read.qxmd.com/read/37793277/cyclovirobuxine-d-alleviates-aldosterone-induced-myocardial-hypertrophy-by-protecting-mitochondrial-function-depending-on-the-mutual-regulation-of-nrf2-sirt3
#5
JOURNAL ARTICLE
Xueting Wang, Hongkun Wu, Jiangfei An, Guangqiong Zhang, Yan Chen, Lingyun Fu, Ling Tao, Guiyou Liang, Xiangchun Shen
BACKGROUND: Cyclovirobuxine D (CVB-D) is a natural alkaloid that exhibits multiple pharmacological activities, such as anti-inflammatory, anti-oxidative stress, and anti-cancer properties. However, its specific protective mechanism of action for myocardial hypertrophy remains unresolved. PURPOSE: This work was to investigate the ameliorative impact of CVB-D in myocardial hypertrophy, and to elucidate aldosterone (ALD)-induced myocardial hypertrophy by inhibiting the SIRT3 mediated Nrf2 activation...
October 2, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37630770/natural-phytochemicals-as-sirt-activators-focus-on-potential-biochemical-mechanisms
#6
REVIEW
Michał Wiciński, Jakub Erdmann, Agnieszka Nowacka, Oskar Kuźmiński, Klaudia Michalak, Kacper Janowski, Jakub Ohla, Adrian Biernaciak, Monika Szambelan, Jan Zabrzyński
Sirtuins are a family of proteins with enzymatic activity. There are seven mammalian sirtuins (SIRT1-SIRT7) that are found in different cellular compartments. They are a part of crucial cellular pathways and are regulated by many factors, such as chemicals, environmental stress, and phytochemicals. Several in vitro and in vivo studies have presented their involvement in anti-inflammatory, antioxidant, and antiapoptotic processes. Recent findings imply that phytochemicals such as resveratrol, curcumin, quercetin, fisetin, berberine, and kaempferol may regulate the activity of sirtuins...
August 14, 2023: Nutrients
https://read.qxmd.com/read/37485771/pterostilbene-enhances-thermogenesis-and-mitochondrial-biogenesis-by-activating-the-sirt1-pgc-1%C3%AE-sirt3-pathway-to-prevent-western-diet-induced-obesity
#7
JOURNAL ARTICLE
Yen-Chun Koh, Shin-Jhih Lin, Kai-Yu Hsu, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
SCOPE: Sirtuin 1/peroxisome proliferator-activated receptor gamma co-activator 1 alpha (SIRT1/PGC-1α) pathway activation is known to promote thermogenesis and mitochondrial biogenesis. Pterostilbene (PSB) and pinostilbene (PIN), the methylated analogs of resveratrol, are potential candidates to enhance thermogenesis and mitochondrial biogenesis. METHOD AND RESULTS: A model of Western diet-induced obesity in mice is designed. Either PSB or PIN is supplemented in the diet for 16 weeks...
July 23, 2023: Molecular Nutrition & Food Research
https://read.qxmd.com/read/37256428/resveratrol-attenuates-chronic-unpredictable-mild-stress-induced-alterations-in-the-sirt1-pgc1%C3%AE-sirt3-pathway-and-associated-mitochondrial-dysfunction-in-mice
#8
JOURNAL ARTICLE
Sidra Tabassum, Afzal Misrani, Hui-Xian Huang, Zai-Yong Zhang, Qiao-Wei Li, Cheng Long
Environmental challenges, specifically chronic stress, have long been associated with neuropsychiatric disorders, including anxiety and depression. Sirtuin-1 (SIRT1) is a NAD+ -dependent deacetylase that is widely distributed in the cortex and is involved in stress responses and neuropsychiatric disorders. Nevertheless, how chronic stress modulates the SIRT1 pathway and associated signaling remains unclear. In this study, we first explored the impact of chronic unpredictable mild stress (CUMS) on the SIRT1/PGC1α/SIRT3 pathway, on GABAergic mechanisms, and on mitophagy, autophagy and apoptosis in mice...
May 31, 2023: Molecular Neurobiology
https://read.qxmd.com/read/37173557/resveratrol-inhibits-lps-induced-apoptosis-in-bovine-mammary-epithelial-cells-the-role-of-pgc1%C3%AE-sirt3-axis
#9
JOURNAL ARTICLE
Lu Ouyang, Huilun Tang, Zilin Liu, Yuan Tian, Xin Gao, Tao Peng, Zuo Wang, Xinyi Lan, Weijun Shen, Dingfu Xiao, Fachun Wan, Lei Liu
Resveratrol (Res) is a bioactive dietary component and alleviates apoptosis in multiple cell types. However, its effect and mechanism on lipopolysaccharide (LPS)-induced bovine mammary epithelial cells (BMEC) apoptosis, which commonly happens in dairy cows with mastitis, is unknown. We hypothesized that Res would inhibit LPS-induced apoptosis in BMEC through SIRT3, a NAD + -dependent deacetylase activated by Res. To test the dose-response effect on apoptosis, 0-50 μM Res were incubated with BMEC for 12 h, followed by 250 μg/mL LPS treatment for 12 h...
May 12, 2023: In Vitro Cellular & Developmental Biology. Animal
https://read.qxmd.com/read/37122170/prevention-of-glutamate-induced-neurodegeneration-by-piceatannol-via-mitochondrial-rescue-in-vitro-and-in-vivo
#10
JOURNAL ARTICLE
Yen-Chun Koh, Dickson Chok, Chun-Han Chang, Chia-Cheng Wei, Chia-Tung Wu, Ko-Chun Cheng, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
BACKGROUND AND SCOPE: Parkinson's disease is one of the neurodegenerative diseases that have no cure. Excitotoxicity induced by excess glutamate is known to be a hallmark of these diseases. Therefore, this study aims to evaluate the preventive effect of piceatannol on glutamate-induced neurodegeneration via mitochondrial rescue. METHODS AND RESULTS: The PC12 cell line and three Caenorhabditis elegans (C. elegans) strains were employed to achieve our aim. In the in vitro study, our results showed that piceatannol could prevent glutamate-induced apoptosis...
April 30, 2023: Molecular Nutrition & Food Research
https://read.qxmd.com/read/37056226/impact-of-resveratrol-loaded-liposomal-nanocarriers-on-heat-stressed-broiler-chickens-effects-on-performance-sirtuin-expression-oxidative-stress-regulators-and-muscle-building-factors
#11
JOURNAL ARTICLE
Asmaa T Y Kishawy, Doaa Ibrahim, Elshimaa M Roushdy, Amira Moustafa, Fatma Eldemery, Elham M Hussein, Fardos A M Hassan, Sara T Elazab, Mohamed Tharwat Elabbasy, Raheela Kanwal, Walid M Kamel, Mohamed R Atteya, Asmaa W Zaglool
Climate change is considered to be the primary cause of heat stress (HS) in broiler chickens. Owing to the unique properties of extracted polyphenols, resveratrol-loaded liposomal nanoparticles (Resv-Lipo NPs) were first explored to mitigate the harmful effects of HS. The dietary role of Resv-Lipo NPs in heat-stressed birds was investigated based on their growth performance, antioxidative potential, and the expression of heat shock proteins, sirtuins, antioxidant, immune, and muscle-building related genes. A total of 250 1-day-old Ross 308 broiler chickens were divided into five experimental groups (5 replicates/group, 10 birds/replicate) for 42 days as follows: the control group was fed a basal diet and reared in thermoneutral conditions, and the other four HS groups were fed a basal diet supplemented with Resv-Lipo NPsI, II, and III at the levels of 0, 50, 100, and 150 mg/kg diet, respectively...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/36946539/development-of-the-thymus-and-kidney-and-effects-of-resveratrol-on-their-aging-in-a-short-lived-fish
#12
JOURNAL ARTICLE
Yanhan Hou, Shasha Li, Hongyan Zhu, Mengxue Qiao, Xiaowen Sun, Guorong Li
Annual fishes of the genus Nothobranchius have been widely used in cognitive, behavioral and genetic studies, and have become an excellent animal model for studying aging. However, the development and degeneration of immune organs in annual fishes and the antagonistic effects of resveratrol remain unclear. In the present study, the development of thymus and kidney was investigated systematically using N. guentheri from larvae, juveniles, young and old fish with H&E staining. We found that thymus primordium was observed first in the larvae at 2 days after hatching (dah)...
March 22, 2023: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/36786945/macrophage-microglia-sirt3-contributes-to-the-anti-inflammatory-effects-of-resveratrol-against-experimental-intracerebral-hemorrhage-in-mice
#13
JOURNAL ARTICLE
Jidong Sun, Chen Pu, ErWan Yang, Hongchen Zhang, Yuan Feng, Peng Luo, Yuefan Yang, Lei Zhang, Xia Li, Xiaofan Jiang, Shuhui Dai
Intracerebral hemorrhage (ICH) is a devastating stroke type with high mortality and disability. Inflammatory response induced by macrophages/microglia (M/Ms) activation is one of the leading causes of brain damage after ICH. The anti-inflammatory effects of resveratrol (RSV) have already been evaluated in several models of central nervous system disease. Therefore, we designed the current study to assess the role of RSV in ICH and explore its downstream mechanism related to Sirt3. The autologous artery blood injection was administrated to create an ICH mouse model...
February 14, 2023: Cellular and Molecular Neurobiology
https://read.qxmd.com/read/36597461/shedding-light-on-structure-function-and-regulation-of-human-sirtuins-a-comprehensive-review
#14
REVIEW
Abhishek Sharma, Pragati Mahur, Jayaraman Muthukumaran, Amit Kumar Singh, Monika Jain
Sirtuins play an important role in signalling pathways associated with various metabolic regulations. They possess mono-ADP-ribosyltransferase or deacylase activity like demalonylase, deacetylase, depalmitoylase, demyristoylase and desuccinylase activity. Sirtuins are histone deacetylases which depends upon nicotinamide adenine dinucleotide (NAD) that deacetylate lysine residues. There are a total of seven human sirtuins that have been identified namely, SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6 and SIRT7. The subcellular location of mammalian sirtuins, SIRT1, SIRT6, and SIRT7 are in the nucleus; SIRT3, SIRT4, and SIRT5 are in mitochondria, and SIRT2 is in cytoplasm...
January 2023: 3 Biotech
https://read.qxmd.com/read/36380567/the-role-of-sirt3-induced-autophagy-in-renal-structural-damage-caused-by-periodontitis-in-rats
#15
JOURNAL ARTICLE
Xu Ding, Yubo Hou, Xinchan Liu, Xin Li, Xiaomeng Liu, Yu Deng, Niuben Cao, Weixian Yu
OBJECTIVE: This research aimed to explore the effect of periodontitis on renal tissues injury in rats and the role of Sirtuin3 (Sirt3) and its regulation of autophagy in this progression. MATERIAL AND METHODS: Thirty Wistar rats were assigned into three groups: control, periodontitis (P), and periodontitis with gavage administration of Sirt3 activator resveratrol (P + RSV). To induce periodontitis, the wire ligature was placed around the cervical region of the rat maxillary first molar...
November 15, 2022: Journal of Periodontal Research
https://read.qxmd.com/read/36143977/synergistic-beneficial-effects-of-resveratrol-and-diet-on-high-fat-diet-induced-obesity
#16
JOURNAL ARTICLE
Osama Abo Alrob, Ramzi A Al-Horani, Zaid Altaany, Mohammad B Nusair
Introduction : Despite decades of research, obesity and its related medical complications remain a major health concern globally. Therefore, novel therapeutic strategies are needed to combat obesity and its numerous debilitating complications. Resveratrol (RES) has a potential therapeutic effect in obesity and diabetes by improving oxidative metabolism and insulin signaling. Background and Objectives : The aim of this study was to investigate the effect of RES treatment on weight loss and glucose and fatty acid metabolism...
September 18, 2022: Medicina
https://read.qxmd.com/read/36086852/resveratrol-reverses-tgf-%C3%AE-1-mediated-invasion-and-metastasis-of-breast-cancer-cells-via-the-sirt3-ampk-autophagy-signal-axis
#17
JOURNAL ARTICLE
Jia Wang, Ping Huang, Xiafang Pan, Chunhua Xia, Hong Zhang, Han Zhao, Zhao Yuan, Jianming Liu, Chao Meng, Fanglan Liu
Resveratrol (Resv) has antitumorigenic and antimetastatic activities; however, the molecular mechanisms underlying the inhibitory effects of Resv on the invasion and metastasis of breast cancer cells are still a subject of debate. In our study, we demonstrated that Resv inhibited tumor cell proliferation and tumor growth. It also suppressed invasion and pulmonary metastasis of breast cancer by reversing the transforming growth factor beta 1 (TGF-β1)-mediated EMT process. Meanwhile, the anticarcinogenic effects of Resv were abolished by the autophagy blocker 3-methyladenine (3-MA) or Beclin 1 small interfering RNA...
September 9, 2022: Phytotherapy Research: PTR
https://read.qxmd.com/read/36080311/resveratrol-reestablishes-mitochondrial-quality-control-in-myocardial-ischemia-reperfusion-injury-through-sirt1-sirt3-mfn2-parkin-pgc-1%C3%AE-pathway
#18
JOURNAL ARTICLE
Minsi Zheng, Yinglu Bai, Xiuyu Sun, Rao Fu, Liya Liu, Mengsi Liu, Zhiyong Li, Xiulan Huang
Resveratrol is a natural polyphenol found in various plants. It has been widely studied on cardiovascular disorders. It is known that resveratrol can activate Sirtuin proteins and participate in cellular energy metabolism through a Sirtuin-dependent pathway. Here, we hypothesized that resveratrol may protect against myocardial ischemia/reperfusion injury (MIRI) through the target of Sirt1/Sirt3 on mitochondrial dynamics, cardiac autophagy, bioenergetics and oxidative damage in hypoxia/reoxygenation (H/R)-induced neonatal rat cardiomyocytes...
August 29, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/35865961/resveratrol-enhances-the-anti-cancer-effects-of-cis-platinum-on-human-cervical-cancer-cell-lines-by-activating-the-sirt3-relative-anti-oxidative-pathway
#19
JOURNAL ARTICLE
Bin Jiang, Qi Tian, Chuqiang Shu, Jing Zhao, Min Xue, Shujuan Zhu
Background: Cervical cancer exerts considerable mortality in the world. The combinations of chemotherapy with cis-platinum were the first-line treatment in late-stage cervical cancer but may cause severe adverse effects. Resveratrol (RES, 3,5,4'-trihydroxy-trans-stilbene) is a phytoalexin, and it showed anti-cancer effects but with low toxicity and side effects. Herein, we examined the anti-cancer effects of cis-platinum combined with RES in human cervical cancer cell lines. Methods: The antiproliferative effect was examined by cell counting and short-term MTT assay...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/35802632/short-term-resveratrol-treatment-restored-the-quality-of-oocytes-in-aging-mice
#20
JOURNAL ARTICLE
Naoki Okamoto, Yorino Sato, Yuta Kawagoe, Takahiko Shimizu, Kazuhiro Kawamura
The quality of oocytes declines by aging, resulting in their low competences for fertility. Here, resveratrol treatment showed increases in the rates of implantation and live offspring as well as decreases in the abortion rate as short as one week after treatment, although the number of ovulated oocytes and the rates of fertilization and blastocyst formation were not changed following resveratrol treatment. Resveratrol treatment did not cause abnormalities mouse estrous cycles and body weights. No abnormality was detected in both fetuses and placentas after 22 weeks of resveratrol treatment and the fetuses had normal fertility...
July 8, 2022: Aging
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