keyword
MENU ▼
Read by QxMD icon Read
search

Inflammation and posttraumatic epilepsy

keyword
https://www.readbyqxmd.com/read/26149793/il-1%C3%AE-associations-with-posttraumatic-epilepsy-development-a-genetics-and-biomarker-cohort-study
#1
Matthew L Diamond, Anne C Ritter, Michelle D Failla, Jennifer A Boles, Yvette P Conley, Patrick M Kochanek, Amy K Wagner
OBJECTIVE: Posttraumatic epilepsy (PTE) is a significant complication following traumatic brain injury (TBI), yet the role of genetic variation in modulating PTE onset is unclear. We hypothesized that TBI-induced inflammation likely contributes to seizure development. We assessed whether genetic variation in the interleukin-1beta (IL-1β) gene, Il-1β levels in cerebral spinal fluid (CSF) and serum, and CSF/serum IL-1β ratios would predict PTE development post-TBI. METHODS: We investigated PTE development in 256 Caucasian adults with moderate-to-severe TBI...
July 2015: Epilepsia
https://www.readbyqxmd.com/read/24754437/il-1%C3%AE-associations-with-posttraumatic-epilepsy-development-a-genetics-and-biomarker-cohort-study
#2
Matthew L Diamond, Anne C Ritter, Michelle D Failla, Jennifer A Boles, Yvette P Conley, Patrick M Kochanek, Amy K Wagner
OBJECTIVE: Posttraumatic epilepsy (PTE) is a significant complication following traumatic brain injury (TBI), yet the role of genetic variation in modulating PTE onset is unclear. We hypothesized that TBI-induced inflammation likely contributes to seizure development. We assessed whether genetic variation in the interleukin-1beta (IL-1β) gene, IL-1β levels in cerebrospinal fluid (CSF) and serum, and CSF/serum IL-1β ratios would predict PTE development post-TBI. METHODS: We investigated PTE development in 256 Caucasian adults with moderate-to-severe TBI...
July 2014: Epilepsia
https://www.readbyqxmd.com/read/23585123/hippocampal-gene-expression-profiling-in-a-rat-model-of-posttraumatic-epilepsy-reveals-temporal-upregulation-of-lipid-metabolism-related-genes
#3
Yuto Ueda, Aya Kitamoto, L James Willmore, Toshio Kojima
Traumatic brain injury occasionally causes posttraumatic epilepsy. To elucidate the molecular events responsible for posttraumatic epilepsy, we established a rodent model that involved the injection of microliter quantities of FeCl3 solution into the amygdalar nuclear complex. We previously compared hippocampal gene expression profiles in the traumatic epilepsy model and normal rats at 5 days after brain injury (acute phase) to determine the role of inflammation. In this study, we focused on later stages of epileptogenesis...
July 2013: Neurochemical Research
https://www.readbyqxmd.com/read/21191651/hippocampal-gene-network-analysis-in-an-experimental-model-of-posttraumatic-epilepsy
#4
Yuto Ueda, Aya Kitamoto, L J Willmore, Toshio Kojima
In the present study, we performed comprehensive gene expression and gene network analyses using a DNA microarray to elucidate the molecular events responsible for the pathology of posttraumatic epilepsy at the partial seizure stage. We used an experimental posttraumatic epilepsy model of amygdalar focal FeCl(3)-injected rats and compared gene expression profiles in the hippocampus at the partial seizure stage (less than stage 3 on Racine's convulsion scale) and that of sham-operated animals. At the partial seizure stage, upregulation of phospholipase A2 (PLA2) and lipid metabolism were observed, which have been reported to be caused by brain injury and seizures in previous studies...
July 2011: Neurochemical Research
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"