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Inflammation and posttraumatic epilepsy

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https://www.readbyqxmd.com/read/29247482/commonalities-in-epileptogenic-processes-from-different-acute-brain-insults-do-they-translate
#1
REVIEW
Pavel Klein, Raymond Dingledine, Eleonora Aronica, Christophe Bernard, Ingmar Blümcke, Detlev Boison, Martin J Brodie, Amy R Brooks-Kayal, Jerome Engel, Patrick A Forcelli, Lawrence J Hirsch, Rafal M Kaminski, Henrik Klitgaard, Katja Kobow, Daniel H Lowenstein, Phillip L Pearl, Asla Pitkänen, Noora Puhakka, Michael A Rogawski, Dieter Schmidt, Matti Sillanpää, Robert S Sloviter, Christian Steinhäuser, Annamaria Vezzani, Matthew C Walker, Wolfgang Löscher
The most common forms of acquired epilepsies arise following acute brain insults such as traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for only 60%-70% of patients and remains symptomatic despite decades of effort to develop epilepsy prevention therapies. Recent preclinical efforts are focused on likely primary drivers of epileptogenesis, namely inflammation, neuron loss, plasticity, and circuit reorganization. This review suggests a path to identify neuronal and molecular targets for clinical testing of specific hypotheses about epileptogenesis and its prevention or modification...
January 2018: Epilepsia
https://www.readbyqxmd.com/read/26149793/il-1%C3%AE-associations-with-posttraumatic-epilepsy-development-a-genetics-and-biomarker-cohort-study
#2
Matthew L Diamond, Anne C Ritter, Michelle D Failla, Jennifer A Boles, Yvette P Conley, Patrick M Kochanek, Amy K Wagner
OBJECTIVE: Posttraumatic epilepsy (PTE) is a significant complication following traumatic brain injury (TBI), yet the role of genetic variation in modulating PTE onset is unclear. We hypothesized that TBI-induced inflammation likely contributes to seizure development. We assessed whether genetic variation in the interleukin-1beta (IL-1β) gene, Il-1β levels in cerebral spinal fluid (CSF) and serum, and CSF/serum IL-1β ratios would predict PTE development post-TBI. METHODS: We investigated PTE development in 256 Caucasian adults with moderate-to-severe TBI...
July 2015: Epilepsia
https://www.readbyqxmd.com/read/24754437/il-1%C3%AE-associations-with-posttraumatic-epilepsy-development-a-genetics-and-biomarker-cohort-study
#3
Matthew L Diamond, Anne C Ritter, Michelle D Failla, Jennifer A Boles, Yvette P Conley, Patrick M Kochanek, Amy K Wagner
OBJECTIVE: Posttraumatic epilepsy (PTE) is a significant complication following traumatic brain injury (TBI), yet the role of genetic variation in modulating PTE onset is unclear. We hypothesized that TBI-induced inflammation likely contributes to seizure development. We assessed whether genetic variation in the interleukin-1beta (IL-1β) gene, IL-1β levels in cerebrospinal fluid (CSF) and serum, and CSF/serum IL-1β ratios would predict PTE development post-TBI. METHODS: We investigated PTE development in 256 Caucasian adults with moderate-to-severe TBI...
July 2014: Epilepsia
https://www.readbyqxmd.com/read/23585123/hippocampal-gene-expression-profiling-in-a-rat-model-of-posttraumatic-epilepsy-reveals-temporal-upregulation-of-lipid-metabolism-related-genes
#4
Yuto Ueda, Aya Kitamoto, L James Willmore, Toshio Kojima
Traumatic brain injury occasionally causes posttraumatic epilepsy. To elucidate the molecular events responsible for posttraumatic epilepsy, we established a rodent model that involved the injection of microliter quantities of FeCl3 solution into the amygdalar nuclear complex. We previously compared hippocampal gene expression profiles in the traumatic epilepsy model and normal rats at 5 days after brain injury (acute phase) to determine the role of inflammation. In this study, we focused on later stages of epileptogenesis...
July 2013: Neurochemical Research
https://www.readbyqxmd.com/read/21191651/hippocampal-gene-network-analysis-in-an-experimental-model-of-posttraumatic-epilepsy
#5
Yuto Ueda, Aya Kitamoto, L J Willmore, Toshio Kojima
In the present study, we performed comprehensive gene expression and gene network analyses using a DNA microarray to elucidate the molecular events responsible for the pathology of posttraumatic epilepsy at the partial seizure stage. We used an experimental posttraumatic epilepsy model of amygdalar focal FeCl(3)-injected rats and compared gene expression profiles in the hippocampus at the partial seizure stage (less than stage 3 on Racine's convulsion scale) and that of sham-operated animals. At the partial seizure stage, upregulation of phospholipase A2 (PLA2) and lipid metabolism were observed, which have been reported to be caused by brain injury and seizures in previous studies...
July 2011: Neurochemical Research
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