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https://www.readbyqxmd.com/read/28623838/economic-analysis-of-an-epilepsy-outreach-model-of-care-in-a-university-hospital-setting
#1
Eimer Maloney, Ronan N McGinty, Daniel J Costello
The prevalence of epilepsy in people with intellectual disability is higher than in the general population and prevalence rates increase with increasing levels of disability. Prevalence rates of epilepsy are highest among those living in residential care. The healthcare needs of people with intellectual disability and epilepsy are complex and deserve special consideration in terms of healthcare provision and access to specialist epilepsy clinics, which are usually held in acute hospital campuses. This patient population is at risk of suboptimal care because of significant difficulties accessing specialist epilepsy care which is typically delivered in the environs of acute hospitals...
June 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28623752/process-evaluation-of-a-multi-component-self-management-intervention-for-adults-with-epilepsy-zmile-study
#2
Loes A M Leenen, Ben F M Wijnen, Jolanda C M van Haastregt, Reina J A de Kinderen, Silvia M A A Evers, Marian H J M Majoie, Caroline M van Heugten
BACKGROUND: People with epilepsy need to monitor and manage their symptoms. They, as well as their relatives, have to deal with the psychological burden, reflected in a reduced quality of life. Support in self-management can be of importance. We have developed a multi-component self-management intervention for patients and their relatives (MCI). This eight-week group intervention is conducted by nurse practitioners and consists of six two-hour sessions. The main components are: 1) providing self-management education, 2) stimulating proactive coping and goal-setting and 3) facilitating peer and social support...
June 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28623728/epilepsy-surgery-in-patients-older-than-50-years-effectiveness-safety-and-predictors-of-outcome
#3
Piergiorgio d' Orio, Veronica Pelliccia, Francesca Gozzo, Francesco Cardinale, Laura Castana, Giorgio Lo Russo, Gabriella Bottini, Pina Scarpa, Massimo Cossu
PURPOSE: Surgery is an effective treatment for drug resistant focal epilepsy. Predictors of seizure outcome have been extensively addressed in the general population but similar data on older patients are still lacking. The aim of this study is to evaluate effectiveness and safety of surgery for patients over 50 years and to investigate variables associated to seizure outcome. METHODS: We performed a single center retrospective study including 50 patients over 50 years treated surgically for drug resistant focal epilepsy between 1997 and 2014...
June 10, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28615981/human-taeniasis-current-insights-into-prevention-and-management-strategies-in-endemic-countries
#4
REVIEW
Anna L Okello, Lian Francesca Thomas
Human taeniasis is a zoonotic condition resulting from infection with the adult stages of Taenia saginata ("beef tapeworm"), Taenia solium ("pork tapeworm") or Taenia asiatica ("Asian tapeworm"). Although these parasites have a worldwide distribution, the overwhelming burden is felt by communities in low- and middle-income countries. This is particularly true for T. solium, whereby infection of the central nervous system with the larval stage of the parasite (neurocysticercosis) is a major cause of acquired epilepsy in low-resource settings...
2017: Risk Management and Healthcare Policy
https://www.readbyqxmd.com/read/28609734/assessment-of-treatment-patterns-and-healthcare-costs-associated-with-probable-lennox-gastaut-syndrome
#5
J Eric Piña-Garza, Georgia D Montouris, Francis Vekeman, Wendy Y Cheng, Edward Tuttle, Philippe Giguere-Duval, Mei Sheng Duh, Vivienne Shen, Timothy B Saurer, Jouko Isojarvi
Lennox-Gastaut syndrome (LGS) is a chronic and severe form of epilepsy characterized by intractable seizures, cognitive impairment, and abnormal electroencephalogram findings with slow spike-wave complexes. It typically presents before age 8, but symptoms continue into adulthood and require lifelong treatment associated with significant clinical burden. Data on LGS-associated healthcare utilization and costs are limited. In this study we use a claims-based LGS classifier based on random forest methodology to identify patients with probable LGS from the a Medicaid multi-state database and assess its prevalence across the age spectrum, healthcare utilization, treatment patterns, costs, and comorbid conditions...
June 10, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28605632/seizure-related-variables-are-predictive-of-attention-and-memory-in-children-with-epilepsy
#6
Danielle N Lordo, Ryan Van Patten, Eliana L Sudikoff, Lisa Harker
Children with epilepsy (CWE) are at greater risk for cognitive deficits and behavioral difficulties than are typically developing healthy children, and particular epileptic symptoms and treatments may contribute to this risk. The current study examined the relationships between four seizure-related variables and attention and memory functioning in a sample of 207 CWE (ages 6-16) using both neurocognitive and parent/teacher-report measures. Sociodemographic, medical, and neuropsychological data were collected from patients' medical charts in a retrospective fashion...
June 9, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28582727/validation-of-the-chinese-version-of-public-attitudes-toward-epilepsy-scale-in-mainland-china
#7
Zongwei Yue, Chanthia Ma, Kheng-Seang Lim, Bo Xiao, Qian Wu, Yi Shu, Zhiping Yue, Yelan Wang, Li Feng
PURPOSE: Epilepsy is a significant yet seriously underappreciated public health issue in Mainland China. The stigma and discrimination toward people with epilepsy (PWE) and their families are especially severe in China based on cultural misconceptions which cause tremendous psychological, economic and social burdens. It is imperative to formulate a targeted public intervention to eliminate knowledge gaps and correct these misconceptions of epilepsy. However, to date, the essential tools that may drive such an intervention by measuring the public perspective on PWEs is lacking in China...
June 2, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28573736/epilepsy-as-a-systemic-condition-link-with-somatic-comorbidities
#8
J Novy, G S Bell, J L Peacock, S M Sisodiya, J W Sander
BACKGROUND: People with epilepsy have more concomitant medical conditions than the general population; these comorbidities play an important role in premature mortality. We sought to generate explanatory hypotheses about the co-occurrence of somatic comorbidities and epilepsy, avoiding causal and treatment-resultant biases. METHODS: We collected clinical, demographic and somatic comorbidity data for 2016 consecutive adults with epilepsy undergoing assessment at a tertiary centre and in 1278 people with epilepsy in the community...
June 1, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28555777/early-ictal-and-interictal-patterns-in-fires-the-sparks-before-the-blaze
#9
Raquel Farias-Moeller, Luca Bartolini, Katelyn Staso, John M Schreiber, Jessica L Carpenter
OBJECTIVE: Febrile infection-related epilepsy syndrome (FIRES) is a catastrophic epileptic encephalopathy described as explosive onset of super refractory status epilepticus (SRSE) in previously healthy children. We describe electroencephalography (EEG) abnormalities in the hyperacute phase of FIRES, with the aim of contributing to the diagnostic characterization of a syndrome otherwise lacking specific biomarkers. METHODS: This is a retrospective single-center, case series of seven children with FIRES...
May 26, 2017: Epilepsia
https://www.readbyqxmd.com/read/28554148/social-media-in-epilepsy-a-quantitative-and-qualitative-analysis
#10
Ying Meng, Lior Elkaim, Justin Wang, Jessica Liu, Naif M Alotaibi, George M Ibrahim, Aria Fallah, Alexander G Weil, Taufik A Valiante, Andres M Lozano, James T Rutka
BACKGROUND: While the social burden of epilepsy has been extensively studied, an evaluation of social media related to epilepsy may provide novel insight into disease perception, patient needs and access to treatments. The objective of this study is to assess patterns in social media and online communication usage related to epilepsy and its associated topics. METHODS: We searched two major social media platforms (Facebook and Twitter) for public accounts dedicated to epilepsy...
June 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28552137/the-natural-history-of-cerebral-arteriovenous-malformations
#11
Anil Can, Bradley A Gross, Rose Du
Cerebral arteriovenous malformations (AVMs) are composed of a complex tangle of abnormal arteries and veins and are a significant source of cerebral hemorrhage and consequent morbidity and mortality in young adults, representing a diagnostic and therapeutic challenge. Current natural-history studies of cerebral AVMs report overall annual rates of 1% and 3% for the risk of epilepsy and hemorrhage, respectively. Unruptured AVMs have an annual hemorrhage rate of 2.2% while ruptured lesions have an annual hemorrhage rate of 4...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28552116/prediction-of-epileptic-seizures-from-eeg-using-analysis-of-ictal-rules-on-poincar%C3%A3-plane
#12
Babak Sharif, Amir Homayoun Jafari
BACKGROUND AND OBJECTIVE: Epilepsy is a neurological disorder that causes recurrent and abrupt seizures which makes the patients insecure. Predicting seizures can reduce the burdens of this disorder. METHODS: A new approach in seizure prediction is presented that includes a novel technique in feature extraction from EEG. The algorithm firsts creates an embedding space from EEG time series. Then it takes samples with most of the information using an optimized and data specific Poincare plane...
July 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28552103/needs-of-exploring-the-burden-of-recent-onset-seizures-due-to-neurocysticercosis-and-challenges-in-southeast-asia-focusing-on-scenario-in-malaysia
#13
REVIEW
Priyadarshi S Sahu, Yvonne A L Lim, Rohela Mahmud, Sushela D Somanath, Chong T Tan, C P Ramachandran
Seizures due to neurocysticercosis (NCC) is a neglected human-to-human transmitted disorder and an emerging problem worldwide. A substantial portion of recent onset seizures is known to be attributed to NCC in Taenia solium (T. solium) endemic areas where populations which neither raise pigs nor eat pig meat are also at risk. High prevalence of NCC causing epilepsy has been reported in the underdeveloped areas of Southeast Asia (SEA) however, only fragmentary information on its incidence is available in countries like Malaysia...
April 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28550723/tyrosine-receptor-kinase-b-gene-variants-ntrk2-variants-are-associated-with-depressive-disorders-in-temporal-lobe-epilepsy
#14
Carolina Machado Torres, Marina Siebert, Hugo Bock, Suelen Mandelli Mota, Juliana Unis Castan, Francisco Scornavacca, Luiza Amaral de Castro, Maria Luiza Saraiva-Pereira, Marino Muxfeldt Bianchin
RATIONALE: Psychiatric comorbidities are highly prevalent in epilepsy, adding an important burden to the disease and profoundly affecting the quality of life of these individuals. Patients with temporal lobe epilepsy (TLE) are especially at risk to develop depression and several lines of evidence suggest that the association of depression with epilepsy might be related to common biological substrates. In this study, we test whether NTRK2 allele variants are associated with mood disorders or depressive disorders in patients with TLE...
June 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28532711/psychiatric-comorbidities-in-new-onset-epilepsy-should-they-be-always-investigated
#15
REVIEW
Andres M Kanner
The new definition of epilepsy establishes that epilepsy is not only a disorder presenting with epileptic seizures but it can be often associated with cognitive and psychiatric comorbidities. In fact, the prevalence of psychiatric comorbidities is relatively high in patients with epilepsy (PWE), as one in three patients will have experienced a psychiatric disorder in the course of their life, with mood and anxiety disorders being the most frequent. Psychiatric comorbidities often precede the onset of the seizure disorder, and affect the life of these patients and the course of the seizure disorder at several levels, including a worse tolerance of pharmacotherapy with antiepileptic drugs (AEDs), in particular the development of iatrogenic psychiatric symptoms from pharmacologic and surgical treatments, an increased mortality risk, a worse quality of life and higher economic burdens of the patient, family and society as a hole...
July 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28502691/long-term-seizure-quality-of-life-depression-and-verbal-memory-outcomes-in-a-controlled-mesial-temporal-lobe-epilepsy-surgical-series-using-portuguese-validated-instruments
#16
Luis Dias, Geisa Angelis, Wagner Teixeira, Luiz Casulari
OBJECTIVE: We aimed to evaluate long-term surgical outcomes in patients treated for mesial temporal lobe epilepsy (MTLE) compared to a similar group of patients that underwent a preoperative evaluation. METHODS: Patient interviews were conducted by an independent neuropsychologist and included a socio-demographic questionnaire and validated versions of the Beck Depression Inventory-II (BDI-II), Adverse Events Profile (AEP), Quality of Life in Epilepsy-31 (QOLIE-31), and Rey Auditory Verbal Learning Test (RAVLT)...
May 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28484525/invasive-aspergillus-sinusitis-with-orbitocranial-extension
#17
Saleh S Baeesa, Rakan F Bokhari, Khalid B Alghamdi, Hisham B Alem, Jaudah A Al-Maghrabi, Tariq A Madani
CONTEXT: Invasive sinonasal aspergillosis is a silently progressive disease that, left untreated, may invade the adjacent intracranial and intra-orbital compartments incurring serious morbidity. AIM: To evaluate our results of a collaborative surgical management plans for patients with invasive sinonasal aspergillosis with orbitocranial extension. SETTING AND DESIGN: Retrospective study. MATERIALS AND METHODS: Between the years 2000 and 2012, 12 patients with Aspergillus sinusitis with orbitocranial extension were treated at our institution...
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28479789/psychiatric-comorbidity-in-children-with-epilepsy-a-cross-sectional-5-years-rural-prevalence-study
#18
Ambrish Sanjay Dharmadhikari, Vinod Kumar Sinha
BACKGROUND: Epilepsy is one of the most common chronic neurological disorders. In children, it has long debilitating course and is associated with comorbidities including psychiatric comorbidity. To tackle this burden of comorbidities, we must know the extent of problem. Hence, there is a need for estimation of prevalence of psychiatry disorder in children with epilepsy. AIM: The present study was aimed at measuring the prevalence of various psychiatry disorders among children suffering from epilepsy...
April 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28462454/the-national-institute-of-neurological-disorders-and-stroke-ninds-epilepsy-therapy-screening-program-etsp
#19
John H Kehne, Brian D Klein, Shamsi Raeissi, Shalini Sharma
For over 40 years, the National Institute of Neurological Disorders and Stroke/National Institutes of Health-funded Anticonvulsant Screening Program has provided a preclinical screening service for participants world-wide that helped identify/characterize new antiseizure compounds, a number of which advanced to the market for the treatment of epilepsy. The newly-renamed Epilepsy Therapy Screening Program (ETSP) has a refocused mission to identify novel agents which will help address the considerable remaining unmet medical needs in epilepsy...
May 2, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28446244/ketogenic-diet-in-the-treatment-of-epilepsy-in-children-under-the-age-of-2-years-study-protocol-for-a-randomised-controlled-trial
#20
Siobhan Titre-Johnson, Natasha Schoeler, Christin Eltze, Ruth Williams, Katharina Vezyroglou, Helen McCullagh, Nick Freemantle, Simon Heales, Rachel Kneen, Louise Marston, Tim Martland, Irwin Nazareth, Elizabeth Neal, Andrew Lux, Alasdair Parker, Shakti Agrawal, Penny Fallon, J Helen Cross
BACKGROUND: The incidence of epilepsy is greatest in the first 2 years of life, an age group where there is generally a poor prognosis for both seizure control and neurodevelopmental outcome. Early control of seizures can be associated with better developmental outcome but many of the epilepsies presenting in infancy are poorly responsive to antiepileptic medication. The ketogenic diet (KD) is a high-fat, low-carbohydrate diet designed to mimic the effects of starvation on the body. Dietary fat is converted into ketones in the body and used as an energy source by the brain...
April 26, 2017: Trials
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