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https://www.readbyqxmd.com/read/29225544/novel-targets-for-developing-antiseizure-and-potentially-antiepileptogenic-drugs
#1
Dipan C Patel, Karen S Wilcox, Cameron S Metcalf
Epilepsy is a chronic neurological disorder caused by abnormal changes in the functions of neuronal circuits and manifested by seizures. It affects patients of all age, substantially worsens the quality of life for the patients as well as their families, and imposes a huge economic burden on the healthcare system. Historically, efforts for discovering and developing antiseizure therapies have been focused on modulating the functions of receptors, transporters, and enzymes expressed by neurons. These drug development efforts have paid off, as we have over 25 antiseizure drugs available in the clinic...
September 2017: Epilepsy Currents
https://www.readbyqxmd.com/read/29221763/cognitive-impairment-and-quality-of-life-of-people-with-epilepsy-and-neurocysticercosis-in-zambia
#2
Anne L Nau, Kabemba E Mwape, Jasmin Wiefek, Kathie Schmidt, Emmanuel Abatih, Pierre Dorny, Nicolas Praet, Clarance Chiluba, Holger Schmidt, Isaac K Phiri, Andrea S Winkler, Sarah Gabriël, Joachim Blocher
Cognitive impairment and quality of life (Qol) are important to assess the burden of epilepsy and neurocysticercosis (NCC), which are common but neglected in Sub-Saharan Africa (SSA). The aims of this study were to assess cognitive performance and Qol of people with epilepsy (PWE) in Zambia and to explore differences in PWE with and without NCC. In this community based, cross-sectional case-control-study, 47 PWE and 50 healthy controls completed five neuropsychological tests (Mini Mental State Examination (MMSE), Digit Span, Selective Reminding Test (SRT), Spatial Recall Test (SPART), Test Battery of Attentional Performance (TAP)) and a World Health Organization (WHO) questionnaire of Qol...
December 5, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29218870/loss-of-function-of-neuroplasticity-related-genes-confers-risk-for-human-neurodevelopmental-disorders
#3
Milo R Smith, Benjamin S Glicksberg, Li Li, Rong Chen, Hirofumi Morishita, Joel T Dudley
High and increasing prevalence of neurodevelopmental disorders place enormous personal and economic burdens on society. Given the growing realization that the roots of neurodevelopmental disorders often lie in early childhood, there is an urgent need to identify childhood risk factors. Neurodevelopment is marked by periods of heightened experience-dependent neuroplasticity wherein neural circuitry is optimized by the environment. If these critical periods are disrupted, development of normal brain function can be permanently altered, leading to neurodevelopmental disorders...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29218701/a-longitudinal-cohort-study-on-the-impact-of-the-clobazam-shortage-on-patients-with-epilepsy
#4
Sara Lukmanji, Khara M Sauro, Colin B Josephson, K Chelsea Altura, Samuel Wiebe, Nathalie Jetté
OBJECTIVE: Drug shortages are occurring at an increasing rate. From May to October 2016, there was a shortage of a level I critical antiepileptic drug, clobazam. We aimed to study the impact of this shortage on patients with epilepsy. METHODS: Adult patients from Calgary's Comprehensive Epilepsy Program who were taking clobazam were approached to participate in the study. Baseline data from the clinic prospective registry included clinical variables and presurvey patient-reported outcomes (PROs) such as the Global Assessment of Severity of Epilepsy, the Global Assessment of Disability Associated with Seizures, and the Quality of Life in Epilepsy questionnaire...
December 7, 2017: Epilepsia
https://www.readbyqxmd.com/read/29212361/psychosocial-burden-and-stigma-perception-of-jordanian-patients-with-epilepsy
#5
Heyam F Dalky, Huda Gharaibeh, Reem Faleh
Epilepsy requires long-term treatment that interferes with individuals' social relationships. Because the effects of psychosocial burden and stigma perception on patients with epilepsy in Jordan have not been explored, the study assessed the relationship among psychosocial burden, stigma of epilepsy, and demographic variables. Subjects were adult patients with epilepsy ( N = 200) registered at hospital clinics. Two published instruments were used to measure outcomes. The participants in the study perceived the burden and stigma of epilepsy as moderate...
December 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/29208845/epilepsy-among-systemic-lupus-erythematosus-patients-insights-from-a-large-database-analysis
#6
Abdulla Watad, Shmuel Tiosano, Nicola Luigi Bragazzi, Francesco Brigo, Doron Comaneshter, Arnon D Cohen, Howard Amital
OBJECTIVE: Epilepsy is characterized by a relevant epidemiological and clinical burden. In the extant literature, an increased risk of seizures has been described in several inflammatory/autoimmune disorders, including systemic lupus erythematosus (SLE). However, so far, relatively few and small size-based studies have been conducted. We aimed to investigate the link between seizure and SLE utilizing a large sample of subjects and extensive data analysis. METHODS: Patients with SLE were compared with age- and sex-matched controls regarding the prevalence of epilepsy in a cross-sectional study...
December 1, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29204183/evaluation-of-outcomes-for-psychosis-and-epilepsy-treatment-delivered-by-primary-health-care-workers-in-nepal-a-cohort-study
#7
M J D Jordans, L Aldridge, N P Luitel, F Baingana, B A Kohrt
Background: Most evaluations of task-shifting have focused on common mental disorders. Much less work has been done on severe mental neurological and substance use (MNS) disorders, such as chronic psychosis and epilepsy. Given the high burden associated with severe MNS and the lack of mental health professionals in low and middle income countries, evaluations on the impact of task-shifting for these disorders are important. Methods: In a rural district of Nepal, a community mental health program, based on World Health Organization's Mental Health Gap Action Programme guidelines, was evaluated using a cohort study design...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29198891/observing-the-advanced-disease-course-in-mucopolysaccharidosis-type-iiia-a-case-series
#8
Elsa Shapiro, Alia Ahmed, Chester Whitley, Kathleen Delaney
This follow-up study of a subgroup of the patients seen in a natural history study of mucopolysaccharidosis type IIIA (Sanfilippo syndrome type A) addressed the adaptive and medical characteristics of their advanced disease manifestations. Of the original 24 patients, specific data was collected on only 58% primarily due to difficulty in locating families and coordinating time for interviews two to four years after the original study. At the last contact with the patient, age range was 8 to 24years of age. Data were collected from telephone interviews from the Vineland Adaptive Behavior Scales II and medical and treatment history...
November 28, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29196573/costs-of-informal-nursing-care-for-patients-with-neurologic-disorders-a-systematic-review
#9
REVIEW
Freya Diederich, Hans-Helmut König, Claudia Mietzner, Christian Brettschneider
OBJECTIVE: To systematically review the economic burden of informal nursing care (INC), often called informal care, caused by multiple sclerosis (MS), Parkinson disease (PD), and epilepsy, with special attention to disease severity. METHODS: We systematically searched MEDLINE, PsycINFO, and NHS Economic Evaluation Database for articles on the cost of illness of the diseases specified. Title, abstract, and full-text review were conducted in duplicate by 2 researchers...
December 1, 2017: Neurology
https://www.readbyqxmd.com/read/29165369/metabolic-epilepsies-commemorative-issue-in-honor-of-professor-uwe-heinemann
#10
EDITORIAL
Richard Kovács, Wolfram S Kunz
Epilepsy is a very frequent, severe, and disabling neurological disorder with has a considerable disease burden worldwide [...].
November 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29163349/kainic-acid-induced-post-status-epilepticus-models-of-temporal-lobe-epilepsy-with-diverging-seizure-phenotype-and-neuropathology
#11
Daniele Bertoglio, Halima Amhaoul, Annemie Van Eetveldt, Ruben Houbrechts, Sebastiaan Van De Vijver, Idrish Ali, Stefanie Dedeurwaerdere
The aim of epilepsy models is to investigate disease ontogenesis and therapeutic interventions in a consistent and prospective manner. The kainic acid-induced status epilepticus (KASE) rat model is a widely used, well-validated model for temporal lobe epilepsy (TLE). As we noted significant variability within the model between labs potentially related to the rat strain used, we aimed to describe two variants of this model with diverging seizure phenotype and neuropathology. In addition, we evaluated two different protocols to induce status epilepticus (SE)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29152443/psychiatric-comorbidities-and-outcomes-in-epilepsy-patients-an-insight-from-a-nationwide-inpatient-analysis-in-the-united-states
#12
Rikinkumar S Patel, Ahmed Elmaadawi, Zeeshan Mansuri, Mandeep Kaur, Kaushal Shah, Suhayl Nasr
Background Psychiatric comorbidities in epilepsy impose significant burdens on patients and their families. It affects their quality of life and medical care and results in cost increases. This study reports the impact of various psychiatric comorbidities in epilepsy patients regarding hospital outcomes and in-hospital mortality. Methods We used the Nationwide Inpatient Sample (NIS) from the Healthcare Cost and Utilization Project (HCUP) from years 2013-2014. We identified epilepsy as the primary diagnosis and psychiatric comorbidities, namely, alcohol abuse, depression, drug abuse, and psychosis, using validated International Classification of Diseases, 9th Revision, Clinical Modification (ICD--9--CM) codes...
September 14, 2017: Curēus
https://www.readbyqxmd.com/read/29141532/seizures-and-antiepileptic-drugs-from-pathophysiology-to-clinical-practice
#13
Nihan CarCaka, Cigdem Ozkara
Recurrent, spontaneous seizure activity caused by abnormal neuronal firing in the brain is a hallmark of epilepsy, a common chronic neurological disorder. Recent research that has expanded the knowledge of the cellular and molecular mechanisms that modulate neuronal excitability and network activity in the brain provides the development and discovery of antiepileptic drugs (AEDs). AED therapy starts with the selection of the most appropriate drug for individual patient on the basis of strategic decision of the risk-benefit ratio...
November 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29127345/the-synthetic-neuroactive-steroid-sge-516-reduces-seizure-burden-and-improves-survival-in-a-dravet-syndrome-mouse-model
#14
Nicole A Hawkins, Michael Lewis, Rebecca S Hammond, James J Doherty, Jennifer A Kearney
Dravet syndrome is an infant-onset epileptic encephalopathy with multiple seizure types that are often refractory to conventional therapies. Treatment with standard benzodiazepines like clobazam, in combination with valproate and stiripentol, provides only modest seizure control. While benzodiazepines are a first-line therapy for Dravet syndrome, they are limited by their ability to only modulate synaptic receptors. Unlike benzodiazepines, neuroactive steroids potentiate a wider-range of GABAA receptors. The synthetic neuroactive steroid SGE-516 is a potent positive allosteric modulator of both synaptic and extrasynaptic GABAA receptors...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29100046/vaccinia-related-kinase-2-vrk2-expression-in-neurological-disorders-schizophrenia-epilepsy-and-multiple-sclerosis
#15
Tahereh Azimi, Soudeh Ghafouri-Fard, Mir Davood Omrani, Mehrdokht Mazdeh, Shahram Arsang-Jang, Arezou Sayad, Mohammad Taheri
BACKGROUND: Schizophrenia (SCZ), epilepsy and Multiple Sclerosis (MS) are neurological disorders with increasing prevalence disturb the patients' lives and are regarded as burdens to the society. As multifactorial disorders, genetic susceptibility factors are involved in their pathogenesis. The Vaccinia-Related Kinase 2 (VRK2) gene codes for a serine threonine kinase recently reported to be contributed in the pathogenesis of some neurological disorders. In the present case-control study we compared the VRK2 gene expression in peripheral blood samples from SCZ, epilepsy and MS patients with normal subjects...
October 25, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29096694/pattern-of-neurological-diseases-in-adult-outpatient-neurology-clinics-in-tertiary-care-hospital
#16
Safia Awan, Saad Shafqat, Ayeesha Kamran Kamal, Aziz Sonawalla, Sarwar Siddiqui, Fowzia Siddiqui, Mohammad Wasay
OBJECTIVES: The burden of neurological diseases in developing countries is rising although little is known about the epidemiology and clinical pattern of neurological disorders. The objective of this study was to understand the burden of disease faced by neurologists a in tertiary care setting. RESULTS: A prospective observational study was conducted of all presentations to neurology clinics at Aga Khan University Hospital Karachi over a period of 2 years. A total of 16,371 out-patients with neurological diseases were seen during the study period...
November 2, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29095321/burden-of-seizure-clusters-on-patients-with-epilepsy-and-caregivers-survey-of-patient-caregiver-and-clinician-perspectives
#17
Patricia E Penovich, Janice Buelow, Kathy Steinberg, Joseph Sirven, James Wheless
OBJECTIVES: To characterize the burden of seizure clusters (SC) on patients and caregivers, a large internet-based survey was conducted. METHODS: The Seizure Cluster Burden of Illness US Survey was conducted online by Harris Poll on behalf of The Epilepsy Foundation in September 2014. Respondents included adult patients 18 years and above with epilepsy or a seizure disorder who had experienced SC in the past year (defined as ≥2 seizures within 24 h outside the patient's typical seizure pattern), caregivers providing current care for a patient with SC (adult or child), and clinicians (neurologists, epileptologists) who treat adult or pediatric patients...
November 2017: Neurologist
https://www.readbyqxmd.com/read/29070664/epidemiology-of-recurrent-traumatic-brain-injury-in-the-general-population-a-systematic-review
#18
REVIEW
Oliver Lasry, Erin Y Liu, Guido Antonio Powell, Jessica Ruel-Laliberté, Judith Marcoux, David L Buckeridge
OBJECTIVE: To comprehensively assess recurrent traumatic brain injury (rTBI) risk and risk factors in the general population. METHODS: We systematically searched MEDLINE, EMBASE, and the references of included studies until January 16, 2017, for general population observational studies reporting rTBI risk or risk factors. Estimates were not meta-analyzed due to significant methodologic heterogeneity between studies, which was evaluated using meta-regression. RESULTS: Twenty-two studies reported recurrence risk and 11 reported on 27 potential risk factors...
October 25, 2017: Neurology
https://www.readbyqxmd.com/read/29063412/epilepsy-knowledge-attitude-and-practice-among-secondary-school-teachers-in-khartoum-state
#19
Mohamed A Elhassan, Amr A Alemairy, Zeinab M Amara, Abdrahman A Hamadelneel, Abbasher H Mohamed, Ahmed A Elaimeri
INTRODUCTION: Epilepsy is a continuing tendency to have seizures, i.e., a convulsion or any transient abnormal event resulting from paroxysmal cerebral neurons discharge, even if the attacks are separated by long intervals. Eighty-nine percent of the global burden of epilepsy is in developing countries. Knowledge about the disease is the cornerstone for its treatment and prevention. OBJECTIVES: The aim of this study was to assess knowledge, attitude, and practice of secondary school teachers toward epilepsy in Khartoum state, Sudan...
October 23, 2017: Neurology and Therapy
https://www.readbyqxmd.com/read/29018647/burden-of-arrhythmias-in-epilepsy-patients-a-nationwide-inpatient-analysis-of-1-4-million-hospitalizations-in-the-united-states
#20
Rupak Desai, Chintan Rupareliya, Upenkumar Patel, Syeda Naqvi, Smit Patel, Abhishek Lunagariya, Zabeen Mahuwala
Arrhythmias have been one of the common complications in epilepsy patients and have also been the reason for death. However, limited data exist about the burden and outcomes of arrhythmias by subtypes in epilepsy. Our study aims at evaluating the burden and differences in outcomes of various subtypes of arrhythmias in epilepsy patient population. The Nationwide Inpatient Sample (NIS) database from 2014 was examined for epilepsy and arrhythmias related discharges using appropriate International Classification of Disease, Ninth Revision Clinical Modification (ICD-9-CM) codes...
August 8, 2017: Curēus
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