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https://www.readbyqxmd.com/read/28747752/erratum-large-scale-analyses-of-common-and-rare-variants-identify-12-new-loci-associated-with-atrial-fibrillation
#1
Ingrid E Christophersen, Michiel Rienstra, Carolina Roselli, Xiaoyan Yin, Bastiaan Geelhoed, John Barnard, Honghuang Lin, Dan E Arking, Albert V Smith, Christine M Albert, Mark Chaffin, Nathan R Tucker, Molong Li, Derek Klarin, Nathan A Bihlmeyer, Siew-Kee Low, Peter E Weeke, Martina Müller-Nurasyid, J Gustav Smith, Jennifer A Brody, Maartje N Niemeijer, Marcus Dörr, Stella Trompet, Jennifer Huffman, Stefan Gustafsson, Claudia Schurmann, Marcus E Kleber, Leo-Pekka Lyytikäinen, Ilkka Seppälä, Rainer Malik, Andrea R V R Horimoto, Marco Perez, Juha Sinisalo, Stefanie Aeschbacher, Sébastien Thériault, Jie Yao, Farid Radmanesh, Stefan Weiss, Alexander Teumer, Seung Hoan Choi, Lu-Chen Weng, Sebastian Clauss, Rajat Deo, Daniel J Rader, Svati H Shah, Albert Sun, Jemma C Hopewell, Stephanie Debette, Ganesh Chauhan, Qiong Yang, Bradford B Worrall, Guillaume Paré, Yoichiro Kamatani, Yanick P Hagemeijer, Niek Verweij, Joylene E Siland, Michiaki Kubo, Jonathan D Smith, David R Van Wagoner, Joshua C Bis, Siegfried Perz, Bruce M Psaty, Paul M Ridker, Jared W Magnani, Tamara B Harris, Lenore J Launer, M Benjamin Shoemaker, Sandosh Padmanabhan, Jeffrey Haessler, Traci M Bartz, Melanie Waldenberger, Peter Lichtner, Marina Arendt, Jose E Krieger, Mika Kähönen, Lorenz Risch, Alfredo J Mansur, Annette Peters, Blair H Smith, Lars Lind, Stuart A Scott, Yingchang Lu, Erwin B Bottinger, Jussi Hernesniemi, Cecilia M Lindgren, Jorge A Wong, Jie Huang, Markku Eskola, Andrew P Morris, Ian Ford, Alex P Reiner, Graciela Delgado, Lin Y Chen, Yii-Der Ida Chen, Roopinder K Sandhu, Man Li, Eric Boerwinkle, Lewin Eisele, Lars Lannfelt, Natalia Rost, Christopher D Anderson, Kent D Taylor, Archie Campbell, Patrik K Magnusson, David Porteous, Lynne J Hocking, Efthymia Vlachopoulou, Nancy L Pedersen, Kjell Nikus, Marju Orho-Melander, Anders Hamsten, Jan Heeringa, Joshua C Denny, Jennifer Kriebel, Dawood Darbar, Christopher Newton-Cheh, Christian Shaffer, Peter W Macfarlane, Stefanie Heilmann-Heimbach, Peter Almgren, Paul L Huang, Nona Sotoodehnia, Elsayed Z Soliman, Andre G Uitterlinden, Albert Hofman, Oscar H Franco, Uwe Völker, Karl-Heinz Jöckel, Moritz F Sinner, Henry J Lin, Xiuqing Guo, Martin Dichgans, Erik Ingelsson, Charles Kooperberg, Olle Melander, Ruth J F Loos, Jari Laurikka, David Conen, Jonathan Rosand, Pim van der Harst, Marja-Liisa Lokki, Sekar Kathiresan, Alexandre Pereira, J Wouter Jukema, Caroline Hayward, Jerome I Rotter, Winfried März, Terho Lehtimäki, Bruno H Stricker, Mina K Chung, Stephan B Felix, Vilmundur Gudnason, Alvaro Alonso, Dan M Roden, Stefan Kääb, Daniel I Chasman, Susan R Heckbert, Emelia J Benjamin, Toshihiro Tanaka, Kathryn L Lunetta, Steven A Lubitz, Patrick T Ellinor
No abstract text is available yet for this article.
July 27, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28747635/aim1-is-an-actin-binding-protein-that-suppresses-cell-migration-and-micrometastatic-dissemination
#2
Michael C Haffner, David M Esopi, Alcides Chaux, Meltem Gürel, Susmita Ghosh, Ajay M Vaghasia, Harrison Tsai, Kunhwa Kim, Nicole Castagna, Hong Lam, Jessica Hicks, Nicolas Wyhs, Debika Biswal Shinohara, Paula J Hurley, Brian W Simons, Edward M Schaeffer, Tamara L Lotan, William B Isaacs, George J Netto, Angelo M De Marzo, William G Nelson, Steven S An, Srinivasan Yegnasubramanian
A defining hallmark of primary and metastatic cancers is the migration and invasion of malignant cells. These invasive properties involve altered dynamics of the cytoskeleton and one of its major structural components β-actin. Here we identify AIM1 (absent in melanoma 1) as an actin-binding protein that suppresses pro-invasive properties in benign prostate epithelium. Depletion of AIM1 in prostate epithelial cells increases cytoskeletal remodeling, intracellular traction forces, cell migration and invasion, and anchorage-independent growth...
July 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28747427/a-biallelic-mutation-in-il6st-encoding-the-gp130-co-receptor-causes-immunodeficiency-and-craniosynostosis
#3
Tobias Schwerd, Stephen R F Twigg, Dominik Aschenbrenner, Santiago Manrique, Kerry A Miller, Indira B Taylor, Melania Capitani, Simon J McGowan, Elizabeth Sweeney, Astrid Weber, Liye Chen, Paul Bowness, Andrew Riordan, Andrew Cant, Alexandra F Freeman, Joshua D Milner, Steven M Holland, Natalie Frede, Miryam Müller, Dirk Schmidt-Arras, Bodo Grimbacher, Steven A Wall, E Yvonne Jones, Andrew O M Wilkie, Holm H Uhlig
Multiple cytokines, including interleukin 6 (IL-6), IL-11, IL-27, oncostatin M (OSM), and leukemia inhibitory factor (LIF), signal via the common GP130 cytokine receptor subunit. In this study, we describe a patient with a homozygous mutation of IL6ST (encoding GP130 p.N404Y) who presented with recurrent infections, eczema, bronchiectasis, high IgE, eosinophilia, defective B cell memory, and an impaired acute-phase response, as well as skeletal abnormalities including craniosynostosis. The p.N404Y missense substitution is associated with loss of IL-6, IL-11, IL-27, and OSM signaling but a largely intact LIF response...
July 26, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28746718/association-of-incident-amelanotic-melanoma-with-phenotypic-characteristics-mc1r-status-and-prior-amelanotic-melanoma
#4
Steven Vernali, Weston T Waxweiler, Patrick M Dillon, Peter A Kanetsky, Irene Orlow, Li Luo, Klaus J Busam, Anne Kricker, Bruce K Armstrong, Hoda Anton-Culver, Stephen B Gruber, Richard P Gallagher, Roberto Zanetti, Stefano Rosso, Lidia Sacchetto, Terence Dwyer, Anne E Cust, David W Ollila, Colin B Begg, Marianne Berwick, Nancy E Thomas
Importance: We previously reported that survival is poorer from histopathologically amelanotic than pigmented melanoma because of more advanced stage at diagnosis. Identifying patients at risk of amelanotic melanoma might enable earlier diagnosis and improved survival; however, the phenotypic characteristics and underlying genetics associated with amelanotic melanoma are unknown. Objective: To determine whether phenotypic characteristics, carriage of MC1R variants, and history of amelanotic melanoma are associated with histopathologically amelanotic melanoma...
July 26, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28746705/risk-of-suicide-attempt-among-soldiers-in-army-units-with-a-history-of-suicide-attempts
#5
Robert J Ursano, Ronald C Kessler, James A Naifeh, Holly Herberman Mash, Carol S Fullerton, Paul D Bliese, Alan M Zaslavsky, Tsz Hin Hinz Ng, Pablo A Aliaga, Gary H Wynn, Hieu M Dinh, James E McCarroll, Nancy A Sampson, Tzu-Cheg Kao, Michael Schoenbaum, Steven G Heeringa, Murray B Stein
Importance: Mental health of soldiers is adversely affected by the death and injury of other unit members, but whether risk of suicide attempt is influenced by previous suicide attempts in a soldier's unit is unknown. Objective: To examine whether a soldier's risk of suicide attempt is influenced by previous suicide attempts in that soldier's unit. Design, Setting, and Participants: Using administrative data from the Army Study to Assess Risk and Resilience in Servicemembers (STARRS), this study identified person-month records for all active-duty, regular US Army, enlisted soldiers who attempted suicide from January 1, 2004, through December 31, 2009 (n = 9650), and an equal-probability sample of control person-months (n = 153 528)...
July 26, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28745305/preparation-and-performance-features-of-wristband-samplers-and-considerations-for-chemical-exposure-assessment
#6
Kim A Anderson, Gary L Points, Carey E Donald, Holly M Dixon, Richard P Scott, Glenn Wilson, Lane G Tidwell, Peter D Hoffman, Julie B Herbstman, Steven G O'Connell
Wristbands are increasingly used for assessing personal chemical exposures. Unlike some exposure assessment tools, guidelines for wristbands, such as preparation, applicable chemicals, and transport and storage logistics, are lacking. We tested the wristband's capacity to capture and retain 148 chemicals including polychlorinated biphenyls (PCBs), pesticides, flame retardants, polycyclic aromatic hydrocarbons (PAHs), and volatile organic chemicals (VOCs). The chemicals span a wide range of physical-chemical properties, with log octanol-air partitioning coefficients from 2...
July 26, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28743384/publication-ethos-in-the-immunogenetics-community
#7
EDITORIAL
Amy B Hahn, Steven G E Marsh, Derek Middleton
No abstract text is available yet for this article.
July 2017: Human Immunology
https://www.readbyqxmd.com/read/28742967/molybdenum-0-dihapto-coordination-of-benzene-and-trifluorotoluene-the-stabilizing-and-chemo-directing-influence-of-a-cf3-group
#8
Jeffery T Myers, Jacob A Smith, Steven J Dakermanji, Justin H Wilde, Katy B Wilson, Philip J Shivokevich, W Dean Harman
The preparation of the complex TpMo(NO)(DMAP)(η2-PhCF3) (5) and TpMo(NO)(DMAP)(η2-benzene) (3) are described. The CF3 group is found to stabilize the metal-arene bond strength in 5 by roughly 3 kcal/mol, compared to 3, allowing the large-scale synthesis and isolation of the trifluorotoluene analog (5, 37 g, 70%). When a benzene solution of 5 is allowed to stand, clean conversion to the benzene analog 3 occurs, and this complex may be precipitated from solution upon the addition of pentane, and isolated...
July 25, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28742398/construct-validity-of-the-ucsd-performance-based-skills-assessment-brief-version-upsa-b-in-hiv-disease
#9
David P Sheppard, Steven Paul Woods, Marizela Verduzco
Among individuals living with HIV disease, approximately 60% experience problems with everyday functioning. The present study investigated the utility of the UCSD Performance-based Skills Assessment-Brief Version (UPSA-B) as a measure of functional capacity in HIV. We utilized a cross-sectional three-group design comparing individuals with HIV- associated neurocognitive disorder (HAND) (HIV + HAND+; n = 27), HIV+ neurocognitively normal individuals (HIV + HAND-; n = 51), and an HIV- comparison group (HIV-; n = 28) with broadly comparable demographics and non-HIV comorbidities...
July 25, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28741898/development-of-a-new-structural-class-of-broadly-acting-hcv-non-nucleoside-inhibitors-leading-to-the-discovery-of-mk-8876
#10
Casey C McComas, Anandan Palani, Wei Chang, M Katharine Holloway, Charles A Lesburg, Peng Li, Nigel Liverton, Peter T Meinke, David B Olsen, Xuanjia Peng, Richard M Soll, Ajay Ummat, Jie Wu, Jin Wu, Nicolas Zorn, Steven W Ludmerer
Studies directed at developing a broadly acting non-nucleoside inhibitor of HCV NS5B led to the discovery of a novel structural class of 5-aryl benzofurans that simultaneously interact with both the palm I and palm II binding regions. An initial candidate was potent in vitro against HCV GT1a and GT1b replicons, and induced multi-log reductions in HCV viral load when orally dosed to chronic GT1 infected chimpanzees. However, in vitro potency losses against clinically relevant GT1a variants prompted a further effort to develop compounds with sustained potency across a broader array of HCV genotypes and mutants...
July 25, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28741749/clinical-outcomes-after-local-field-conformal-reirradiation-of-patients-with-retropharyngeal-nodal-metastasis
#11
Courtney Pollard, Theresa P Nguyen, Sweet Ping Ng, Steven J Frank, Adam S Garden, Gary B Gunn, Clifton D Fuller, Beth M Beadle, William H Morrison, Shah J Shah, He Wang, Sam Tung, Conjun Wang, Lawrence D Ginsberg, Mark E Zafereo, Erich M Sturgis, Shirley Y Su, Ehab Y Hanna, David I Rosenthal, Jack Phan
BACKGROUND: The purpose of this study was to present our experience with retropharyngeal node reirradiation using highly conformal radiotherapy (RT). METHODS: A retrospective screen of 2504 consecutively irradiated patients with head and neck malignancies between 2005 and 2015 identified 19 patients who underwent reirradiation for retropharyngeal node metastasis. Clinical and toxicity outcomes were assessed in these patients. RESULTS: Thirteen patients (68%) had squamous cell carcinoma...
July 25, 2017: Head & Neck
https://www.readbyqxmd.com/read/28741123/neoadjuvant-radiotherapy-is-associated-with-r0-resection-and-improved-survival-for-patients-with-extremity-soft-tissue-sarcoma-undergoing-surgery-a-national-cancer-database-analysis
#12
Alicia A Gingrich, Sarah B Bateni, Arta M Monjazeb, Morgan A Darrow, Steven W Thorpe, Amanda R Kirane, Richard J Bold, Robert J Canter
BACKGROUND: Neoadjuvant radiotherapy (RT) is increasingly advocated for the management of soft tissue sarcoma (STS). Therefore, this study sought to characterize the impact of neoadjuvant RT on rates of R0 resection and overall survival (OS) in extremity STS patients undergoing surgery. METHODS: From January 2003 to December 2012, the study identified patients with a diagnosis of extremity STS from the National Cancer Database. After exclusion of patients younger than 18 years, not treated by surgery, who had metastases at diagnosis, intraoperative RT, and missing or unknown data, 27,969 patients were identified...
July 24, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28740934/patient-reported-distress-and-survival-among-patients-receiving-definitive-radiation-therapy
#13
Yacob Habboush, Robert P Shannon, Shehzad K Niazi, Laeticia Hollant, Megan Single, Katherine Gaines, Bridget Smart, Nicolette T Chimato, Michael G Heckman, Steven J Buskirk, Laura A Vallow, Katherine S Tzou, Stephen J Ko, Jennifer L Peterson, Heather A Biers, Atiya B Day, Kimberly A Nelson, Jeff A Sloan, Michele Y Halyard, Robert C Miller
OBJECTIVE: Patient-reported distress (PRD) has not been well assessed in association with survival after radiation therapy (RT). The aims of this study were to evaluate the association between PRD level and survival after definitive RT and to identify the main causes of distress in definitive RT patients. METHODS AND MATERIALS: A total of 678 consecutive patients receiving definitive RT at our institution from April 2012 through May 2015 were included. All patients answered a PRD questionnaire that contained 30 items related to possible causes of distress, which could be rated from 1 (no distress) to 5 (high distress)...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28737579/prostate-specific-membrane-antigen-targeted-imaging-with-18f-dcfpyl-in-high-grade-gliomas
#14
Roberto Andres Salas Fragomeni, Joshua R Menke, Matthias Holdhoff, Clare Ferrigno, John Joseph Laterra, Lilja B Solnes, Mehrbod S Javadi, Zsolt Szabo, Martin G Pomper, Steven P Rowe
High-grade gliomas (World Health Organization grade III-IV) are highly lethal primary brain tumors. Imaging modalities, including MRI and FDG PET, provide a limited ability to differentiate treatment effects (such as radiation necrosis) from recurrent or residual tumor. As the first step in validating the applicability of prostate-specific membrane antigen (PSMA)-targeted imaging in high-grade gliomas, we evaluated the ability of the PSMA-targeted small molecule [F]DCFPyL (2-(3-(1carboxy-5-(6-[F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid) to image high-grade gliomas in a series of 3 prospectively recruited patients...
July 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28737440/secukinumab-improves-scalp-pain-itching-scaling-and-quality-of-life-in-patients-with-moderate-to-severe-scalp-psoriasis
#15
Steven R Feldman, Lawrence Green, Alexa B Kimball, Kimberly Siu, Yang Zhao, Vivian Herrera, Judit Nyirady, Andrew F Alexis
INTRODUCTION: Scalp psoriasis adversely affects patients' lives and is often resistant to treatment however it has not been a major focus of a clinical study. This analysis assessed the effect of secukinumab on patient-reported outcomes (PRO) of scalp psoriasis. METHODS: A randomized, double-blind, placebo-controlled, multicenter study was conducted in 102 adult patients with moderate-to-severe scalp psoriasis. Patients were randomized 1:1 to secukinumab 300mg or placebo...
July 24, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28736868/high-modulus-low-cost-carbon-fibers-from-polyethylene-enabled-by-boron-catalyzed-graphitization
#16
Bryan E Barton, Michael J Behr, Jasson T Patton, Eric J Hukkanen, Brian G Landes, Weijun Wang, Nicholas Horstman, James E Rix, Denis Keane, Steven Weigand, Mark Spalding, Chris Derstine
Currently, carbon fibers (CFs) from the solution spinning, air oxidation, and carbonization of polyacrylonitrile impose a lower price limit of ≈$10 per lb, limiting the growth in industrial and automotive markets. Polyethylene is a promising precursor to enable a high-volume industrial grade CF as it is low cost, melt spinnable and has high carbon content. However, sulfonated polyethylene (SPE)-derived CFs have thus far fallen short of the 200 GPa tensile modulus threshold for industrial applicability. Here, a graphitization process is presented catalyzed by the addition of boron that produces carbon fiber with >400 GPa tensile modulus at 2400 °C...
July 24, 2017: Small
https://www.readbyqxmd.com/read/28736732/a-systematic-review-of-studies-of-web-portals-for-patients-with-diabetes-mellitus
#17
REVIEW
Steven S Coughlin, Lovoria B Williams, Christos Hatzigeorgiou
Patient web portals are password-protected online websites that offer patients 24-hour access to personal health information from anywhere with an Internet connection. Due to advances in health information technologies, there has been increasing interest among providers and researchers in patient web portals for use by patients with diabetes and other chronic conditions. This article, which is based upon bibliographic searches in PubMed, reviews web portals for patients with diabetes mellitus including patient web portals tethered to electronic medical records and web portals developed specifically for patients with diabetes...
2017: MHealth
https://www.readbyqxmd.com/read/28736441/nationally-representative-equations-that-include-resistance-and-reactance-for-the-prediction-of-percent-body-fat-in-americans
#18
J Stevens, K P Truesdale, J Cai, F-S Ou, K R Reynolds, S B Heymsfield
BACKGROUND/OBJECTIVES: Resistance and reactance collected by bioelectrical impedance (BIA) can be used in equations to estimate percent body fat at relatively low cost and subject burden. To our knowledge no such equations have been developed in a nationally representative sample. SUBJECTS/METHODS: Dual-energy X-ray absorptiometry (DXA) assessed percent body fat from the 1999-2004 NHANES was the criterion method for development of sex-specific percent body fat equations using up to 6467 males or 4888 females 8 to 49 years of age...
July 24, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28736318/psma-targeted-18-f-dcfpyl-pet-ct-in-the-preoperative-staging-of-men-with-high-risk-prostate-cancer-results-of-a-prospective-phase-ii-single-center-study
#19
Michael A Gorin, Steven P Rowe, Hiten D Patel, Igor Vidal, Margarita Mana-Ay, Mehrbod S Javadi, Lilja B Solnes, Ashley E Ross, Edward M Schaeffer, Trinity J Bivalacqua, Alan W Partin, Kenneth J Pienta, Zsolt Szabo, Angelo M De Marzo, Martin G Pomper, Mohamad E Allaf
PURPOSE: To prospectively evaluate the diagnostic performance of PSMA-targeted (18)F-DCFPyL PET/CT in the preoperative staging of men at high risk of harboring metastatic prostate cancer despite a negative conventional staging evaluation. MATERIALS AND METHODS: Men with clinically localized high or very-high risk prostate cancer were imaged with (18)F-DCFPyL PET/CT prior to undergoing radical prostatectomy with a standardized pelvic lymph node dissection. PET/CT scans were interpreted by two blinded nuclear medicine readers and were assessed for inter-reader variability as well as diagnostic accuracy for pelvic lymph node staging...
July 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28735860/are-oral-and-maxillofacial-surgery-residents-being-adequately-trained-to-care-for-pediatric-patients
#20
Shelly Abramowicz, Leonard B Kaban, Andrew S Wurtzel, Steven M Roser
OBJECTIVE: To evaluate whether current oral and maxillofacial surgery (OMS) residents are receiving adequate training and experience to perform specific surgical procedures and anesthesia for pediatric patients. STUDY DESIGN: A 17-question survey was sent electronically to fellows of the American Academy of Craniomaxillofacial Surgeons. Descriptive data for individual surgeons, their associated residency programs, and the quantity of specific pediatric procedures they performed were collected...
May 4, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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