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https://www.readbyqxmd.com/read/29331034/effects-of-in-situ-selenium-exposure-and-maternal-transfer-on-survival-and-deformities-of-brown-trout-salmo-trutta-fry
#1
Sean M Covington, Rami B Naddy, Alan L Prouty, Steven A Werner, Mark Dunn Lewis
Offspring of wild adult brown trout exposed to a range of selenium (Se) concentrations were reared in a laboratory setting to primarily assess effects on survival and deformities. Maternal whole body Se concentrations ranged from 4.7 to 22.6 mg/kg dry weight (dw) for wild fish. Corresponding Se concentrations in embryos ranged from 6.2 to 40.3 mg/kg dw. Significant relationships were found between embryo and whole-body tissue concentrations. Increasing egg Se concentrations were correlated with decreasing survival; however, hatch success was not significantly correlated with increasing embryo Se...
January 13, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29330524/nf-%C3%AE%C2%BAb-inducing-kinase-is-a-therapeutic-target-for-systemic-lupus-erythematosus
#2
Hans D Brightbill, Eric Suto, Nicole Blaquiere, Nandhini Ramamoorthi, Swathi Sujatha-Bhaskar, Emily B Gogol, Georgette M Castanedo, Benjamin T Jackson, Youngsu C Kwon, Susan Haller, Justin Lesch, Karin Bents, Christine Everett, Pawan Bir Kohli, Sandra Linge, Laura Christian, Kathy Barrett, Allan Jaochico, Leonid M Berezhkovskiy, Peter W Fan, Zora Modrusan, Kelli Veliz, Michael J Townsend, Jason DeVoss, Adam R Johnson, Robert Godemann, Wyne P Lee, Cary D Austin, Brent S McKenzie, Jason A Hackney, James J Crawford, Steven T Staben, Moulay H Alaoui Ismaili, Lawren C Wu, Nico Ghilardi
NF-κB-inducing kinase (NIK) mediates non-canonical NF-κB signaling downstream of multiple TNF family members, including BAFF, TWEAK, CD40, and OX40, which are implicated in the pathogenesis of systemic lupus erythematosus (SLE). Here, we show that experimental lupus in NZB/W F1 mice can be treated with a highly selective and potent NIK small molecule inhibitor. Both in vitro as well as in vivo, NIK inhibition recapitulates the pharmacological effects of BAFF blockade, which is clinically efficacious in SLE...
January 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29330367/characterization-of-human-small-heat-shock-protein-hspb1-%C3%AE-crystallin-domain-localized-mutants-associated-with-hereditary-motor-neuron-diseases
#3
Stephen D Weeks, Lydia K Muranova, Michelle Heirbaut, Steven Beelen, Sergei V Strelkov, Nikolai B Gusev
Congenital mutations in human small heat shock protein HSPB1 (HSP27) have been linked to Charcot-Marie-Tooth disease, a commonly occurring peripheral neuropathy. Understanding the molecular mechanism of such mutations is indispensable towards developing future therapies for this currently incurable disorder. Here we describe the physico-chemical properties of the autosomal dominant HSPB1 mutants R127W, S135F and R136W. Despite having a nominal effect on thermal stability, the three mutations induce dramatic changes to quaternary structure...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330156/application-of-receptor-theory-to-the-design-and-use-of-fixed-proportion-mu-opioid-agonist-and-antagonist-mixtures-in-rhesus-monkeys
#4
Jeremy C Cornelissen, Samuel Obeng, Kenner C Rice, Yan Zhang, S Stevens Negus, Matthew Banks
Receptor theory predicts that fixed-proportion mixtures of a competitive, reversible agonist (e.g. fentanyl) and antagonist (e.g. naltrexone) at a common receptor (e.g. mu opioid receptors; MOR) will result in antagonist proportion-dependent decreases in apparent efficacy of the mixtures and downward shifts in mixture dose-effect functions. The present study tested this hypothesis by evaluating behavioral effects of fixed-proportion fentanyl/naltrexone mixtures in a warm-water tail-withdrawal procedure in rhesus monkeys (n=4)...
January 12, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29329883/oxidation-damage-mechanisms-and-reasons-for-revision-of-sequentially-annealed-highly-crosslinked-polyethylene-in-total-knee-arthroplasty
#5
Daniel W MacDonald, Genymphas B Higgs, Antonia F Chen, Arthur L Malkani, Michael A Mont, Steven M Kurtz
BACKGROUND: Sequentially annealed, highly crosslinked polyethylene (HXLPE) has been used clinically in total knee arthroplasty (TKA) for over a decade. However, little is known about the revision reasons; its surface damage mechanisms; or its in vivo oxidative stability relative to conventional polyethylene. We asked whether retrieved HLXPE tibial inserts exhibited: (1) similar revision reasons; (2) improved resistance to surface damage; and (3) improved oxidative stability, when compared with conventional gamma inert sterilized polyethylene inserts...
September 25, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29328724/origins-of-singlet-fission-in-solid-pentacene-from-an-ab%C3%A2-initio-green-s-function-approach
#6
Sivan Refaely-Abramson, Felipe H da Jornada, Steven G Louie, Jeffrey B Neaton
We develop a new first-principles approach to predict and understand rates of singlet fission with an ab initio Green's-function formalism based on many-body perturbation theory. Starting with singlet and triplet excitons computed from a GW plus Bethe-Salpeter equation approach, we calculate the exciton-biexciton coupling to lowest order in the Coulomb interaction, assuming a final state consisting of two noninteracting spin-correlated triplets with finite center-of-mass momentum. For crystalline pentacene, symmetries dictate that the only purely Coulombic fission decay process from a bright singlet state requires a final state consisting of two inequivalent nearly degenerate triplets of nonzero, equal and opposite, center-of-mass momenta...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29327888/safety-of-degludec-versus-glargine-in-type-2-diabetes
#7
Steven P Marso, John B Buse
No abstract text is available yet for this article.
November 16, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29327356/gene-specific-variant-classifier-dpyd-varifier-to-identify-deleterious-alleles-of-dihydropyrimidine-dehydrogenase
#8
Shikshya Shrestha, Cheng Zhang, Calvin R Jerde, Qian Nie, Hu Li, Steven M Offer, Robert B Diasio
Deleterious variants in dihydropyrimidine dehydrogenase (DPD, DPYD gene) can be highly predictive of clinical toxicity to the widely prescribed chemotherapeutic 5-fluorouracil (5-FU). However, there is very limited data pertaining to the functional consequences of the >450 reported non-synonymous DPYD variants. We developed a DPYD-specific variant classifier (DPYD-Varifier) using machine learning and in vitro functional data for 156 missense DPYD variants. The developed model showed 85% accuracy and outperformed other in silico prediction tools...
January 12, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29326199/genome-sequences-of-four-cluster-p-mycobacteriophages
#9
Erin L Doyle, Christy L Fillman, Nathan S Reyna, Deborah M Tobiason, Daniel E Westholm, Jonathan L Askins, Brittany P Backus, Ashlynn C Baker, Harrison S Ballard, Paul J Bisesi, Logan Bond, Deanna Byrnes, Hannah Carlstedt, Kinnon S Dodson, Megan J Fallert, Kyla J Foster, Daniel N Games, Tristan R Grams, Nancy A Guild, Autumn Hurd, Nicholas Iwata, Cassidy R Kepler, Lucinda R Krenzke, Kelly Luekens, Jackie Lewis, Cali McEntee, Justin C McGee, Noah Nalley, Ruth C Plymale, Jade Prochaska, Reid G Rogers, Jessica B Schipper, Kelsey Snyder, Kali Uhrich, Chelsey D Vermillion, Sarah K Vickers, Meredyth D Wenta, Tyler Z Yates, Chas F Young, Ty H Stoner, Welkin H Pope, Deborah Jacobs-Sera, Rebecca A Garlena, Daniel A Russell, Steven G Cresawn, Graham F Hatfull
Four bacteriophages infecting Mycobacterium smegmatis mc2155 (three belonging to subcluster P1 and one belonging to subcluster P2) were isolated from soil and sequenced. All four phages are similar in the left arm of their genomes, but the P2 phage differs in the right arm. All four genomes contain features of temperate phages.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29326102/collectively-improving-our-teaching-attempting-biology-department-wide-professional-development-in-scientific-teaching
#10
Melinda T Owens, Gloriana Trujillo, Shannon B Seidel, Colin D Harrison, Katherine M Farrar, Hilary P Benton, J R Blair, Katharyn E Boyer, Jennifer L Breckler, Laura W Burrus, Dana T Byrd, Natalia Caporale, Edward J Carpenter, Yee-Hung M Chan, Joseph C Chen, Lily Chen, Linda H Chen, Diana S Chu, William P Cochlan, Robyn J Crook, Karen D Crow, José R de la Torre, Wilfred F Denetclaw, Lynne M Dowdy, Darleen Franklin, Megumi Fuse, Michael A Goldman, Brinda Govindan, Michael Green, Holly E Harris, Zheng-Hui He, Stephen B Ingalls, Peter Ingmire, Amber R B Johnson, Jonathan D Knight, Gretchen LeBuhn, Terrye L Light, Candace Low, Lance Lund, Leticia M Márquez-Magaña, Vanessa C Miller-Sims, Christopher A Moffatt, Heather Murdock, Gloria L Nusse, V Thomas Parker, Sally G Pasion, Robert Patterson, Pleuni S Pennings, Julio C Ramirez, Robert M Ramirez, Blake Riggs, Rori V Rohlfs, Joseph M Romeo, Barry S Rothman, Scott W Roy, Tatiane Russo-Tait, Ravinder N M Sehgal, Kevin A Simonin, Greg S Spicer, Jonathon H Stillman, Andrea Swei, Leslie C Tempe, Vance T Vredenburg, Steven L Weinstein, Andrew G Zink, Loretta A Kelley, Carmen R Domingo, Kimberly D Tanner
Many efforts to improve science teaching in higher education focus on a few faculty members at an institution at a time, with limited published evidence on attempts to engage faculty across entire departments. We created a long-term, department-wide collaborative professional development program, Biology Faculty Explorations in Scientific Teaching (Biology FEST). Across 3 years of Biology FEST, 89% of the department's faculty completed a weeklong scientific teaching institute, and 83% of eligible instructors participated in additional semester-long follow-up programs...
2018: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29325868/canadian-genome-wide-association-study-and-meta-analysis-confirm-hla-as-a-risk-factor-for-peanut-allergy-independent-of-asthma
#11
Yuka Asai, Aida Eslami, C Dorien van Ginkel, Loubna Akhabir, Ming Wan, David Yin, George Ellis, Moshe Ben-Shoshan, Ingo Marenholz, David Martino, Manuel A Ferreira, Katrina Allen, Bruce Mazer, Hans de Groot, Nicolette W de Jong, Roy Gerth van Wijk, Anthony E J Dubois, Sarah Grosche, Sarah Ashley, Franz Rüschendorf, Birgit Kalb, Kirsten Beyer, Markus M Nöthen, Young-Ae Lee, Rick Chin, Steven Cheuk, Joshua Hoffman, Eric Jorgensen, John S Witte, Ronald B Melles, Xiumei Hong, Xiaobin Wang, Jennie Hui, Arthur W Bill Musk, Michael Hunter, Alan L James, Gerard H Koppelman, Andrew J Sandford, Ann E Clarke, Denise Daley
No abstract text is available yet for this article.
January 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29325658/tele-motivational-interviewing-for-cancer-survivors-feasibility-preliminary-efficacy-and%C3%A2-lessons-learned
#12
Ashlea Braun, James Portner, Elizabeth M Grainger, Emily B Hill, Gregory S Young, Steven K Clinton, Colleen K Spees
OBJECTIVE: Determine the feasibility, acceptability, and efficacy of tele-Motivational Interviewing (MI) for overweight cancer survivors. DESIGN: Six-month nonrandomized phase 2 clinical trial. SETTING: Urban garden and remote platforms. PARTICIPANTS: Overweight and obese cancer survivors post active treatment. INTERVENTION: Remote tele-MI from a trained registered dietitian nutritionist (RDN)...
January 2018: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29323151/downregulation-of-heat-shock-protein-70-impairs-osteogenic-and-chondrogenic-differentiation-in-human-mesenchymal-stem-cells
#13
Chenghai Li, Kristifor Sunderic, Steven B Nicoll, Sihong Wang
Human mesenchymal stem cells (hMSCs) show promise for bone and cartilage regeneration. Our previous studies demonstrated that hMSCs with periodic mild heating had enhanced osteogenic and chondrogenic differentiation with significantly upregulated heat shock protein 70 (HSP70). However, the role of HSP70 in adult tissue regeneration is not well studied. Here, we revealed an essential regulatory mechanism of HSP70 in osteogenesis and chondrogenesis using adult hMSCs stably transfected with specific shRNAs to knockdown HSP70...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322104/soil-total-carbon-and-nitrogen-and-crop-yields-after-eight-years-of-tillage-crop-rotation-and-cultural-practice
#14
Upendra M Sainju, Andrew W Lenssen, Brett L Allen, William B Stevens, Jalal D Jabro
Information on the long-term effect of management practices on soil C and N stocks is lacking. An experiment was conducted from 2004 to 2011 in the northern Great Plains, USA to examine the effects of tillage, crop rotation, and cultural practice on annualized crop residue (stems + leaves) returned to the soil and grain yield, and soil total C (STC) and total N (STN) stocks at the 0-120 cm depth. Tillage practices were no-tillage (NT) and conventional tillage (CT) and crop rotations were continuous spring wheat (Triticum aestivum L...
December 2017: Heliyon
https://www.readbyqxmd.com/read/29321543/a-new-large-bodied-omnivorous-bat-noctilionoidea-mystacinidae-reveals-lost-morphological-and-ecological-diversity-since-the-miocene-in-new-zealand
#15
Suzanne J Hand, Robin M D Beck, Michael Archer, Nancy B Simmons, Gregg F Gunnell, R Paul Scofield, Alan J D Tennyson, Vanesa L De Pietri, Steven W Salisbury, Trevor H Worthy
A new genus and species of fossil bat is described from New Zealand's only pre-Pleistocene Cenozoic terrestrial fauna, the early Miocene St Bathans Fauna of Central Otago, South Island. Bayesian total evidence phylogenetic analysis places this new Southern Hemisphere taxon among the burrowing bats (mystacinids) of New Zealand and Australia, although its lower dentition also resembles Africa's endemic sucker-footed bats (myzopodids). As the first new bat genus to be added to New Zealand's fauna in more than 150 years, it provides new insight into the original diversity of chiropterans in Australasia...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321336/neuroimaging-identifies-patients-most-likely-to-respond-to-a-restorative-stroke-therapy
#16
Jessica M Cassidy, George Tran, Erin B Quinlan, Steven C Cramer
BACKGROUND AND PURPOSE: Patient heterogeneity reduces statistical power in clinical trials of restorative therapies. Valid predictors of treatment responsiveness are needed, and several have been studied with a focus on corticospinal tract (CST) injury. We studied performance of 4 such measures for predicting behavioral gains in response to motor training therapy. METHODS: Patients with subacute-chronic hemiparetic stroke (n=47) received standardized arm motor therapy, and change in arm Fugl-Meyer score was calculated from baseline to 1 month post-therapy...
January 10, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29321276/ifn-regulatory-factor-3-balances-th1-and-t-follicular-helper-immunity-during-nonlethal-blood-stage-plasmodium-infection
#17
Kylie R James, Megan S F Soon, Ismail Sebina, Daniel Fernandez-Ruiz, Gayle Davey, Urijah N Liligeto, Arya Sheela Nair, Lily G Fogg, Chelsea L Edwards, Shannon E Best, Lianne I M Lansink, Kate Schroder, Jane A C Wilson, Rebecca Austin, Andreas Suhrbier, Steven W Lane, Geoffrey R Hill, Christian R Engwerda, William R Heath, Ashraful Haque
Differentiation of CD4+ Th cells is critical for immunity to malaria. Several innate immune signaling pathways have been implicated in the detection of blood-stage Plasmodium parasites, yet their influence over Th cell immunity remains unclear. In this study, we used Plasmodium-reactive TCR transgenic CD4+ T cells, termed PbTII cells, during nonlethal P. chabaudi chabaudi AS and P. yoelii 17XNL infection in mice, to examine Th cell development in vivo. We found no role for caspase1/11, stimulator of IFN genes, or mitochondrial antiviral-signaling protein, and only modest roles for MyD88 and TRIF-dependent signaling in controlling PbTII cell expansion...
January 10, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29321258/functional-variants-in-the-lrrk2-gene-confer-shared-effects-on-risk-for-crohn-s-disease-and-parkinson-s-disease
#18
Ken Y Hui, Heriberto Fernandez-Hernandez, Jianzhong Hu, Adam Schaffner, Nathan Pankratz, Nai-Yun Hsu, Ling-Shiang Chuang, Shai Carmi, Nicole Villaverde, Xianting Li, Manual Rivas, Adam P Levine, Xiuliang Bao, Philippe R Labrias, Talin Haritunians, Darren Ruane, Kyle Gettler, Ernie Chen, Dalin Li, Elena R Schiff, Nikolas Pontikos, Nir Barzilai, Steven R Brant, Susan Bressman, Adam S Cheifetz, Lorraine N Clark, Mark J Daly, Robert J Desnick, Richard H Duerr, Seymour Katz, Todd Lencz, Richard H Myers, Harry Ostrer, Laurie Ozelius, Haydeh Payami, Yakov Peter, John D Rioux, Anthony W Segal, William K Scott, Mark S Silverberg, Jeffery M Vance, Iban Ubarretxena-Belandia, Tatiana Foroud, Gil Atzmon, Itsik Pe'er, Yiannis Ioannou, Dermot P B McGovern, Zhenyu Yue, Eric E Schadt, Judy H Cho, Inga Peter
Crohn's disease (CD), a form of inflammatory bowel disease, has a higher prevalence in Ashkenazi Jewish than in non-Jewish European populations. To define the role of nonsynonymous mutations, we performed exome sequencing of Ashkenazi Jewish patients with CD, followed by array-based genotyping and association analysis in 2066 CD cases and 3633 healthy controls. We detected association signals in the LRRK2 gene that conferred risk for CD (N2081D variant, P = 9.5 × 10-10) or protection from CD (N551K variant, tagging R1398H-associated haplotype, P = 3...
January 10, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29320587/a-randomized-study-to-assess-the-efficacy-of-skin-rejuvenation-therapy-in-combination-with-neurotoxin-and-full-facial-filler-treatments
#19
Steven H Dayan, Thuy-Van T Ho, Jonathan T Bacos, Nimit D Gandhi, Arjun Kalbag, Selika Gutierrez-Borst
<p>BACKGROUND: Although non-surgical treatment options for facial rejuvenation are well-established, the literature remains limited regarding the combined effect of topical skin treatment with filler and neurotoxin on patient appearance and satisfaction. The objectives of this study were to assess the impact of a skin rejuvenation therapy in combination with neurotoxin or hyaluronic acid filler injection on skin quality and general aesthetic improvement as well as on short-term self-esteem.</p> <p>METHODS: From 2015 to 2017, 20 female patients were enrolled in our study and were randomized into two groups...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29320540/discerning-suicide-in-drug-intoxication-deaths-paucity-and-primacy-of-suicide-notes-and-psychiatric-history
#20
Ian R H Rockett, Eric D Caine, Hilary S Connery, Gail D'Onofrio, David J Gunnell, Ted R Miller, Kurt B Nolte, Mark S Kaplan, Nestor D Kapusta, Christa L Lilly, Lewis S Nelson, Sandra L Putnam, Steven Stack, Peeter Värnik, Lynn R Webster, Haomiao Jia
OBJECTIVE: A paucity of corroborative psychological and psychiatric evidence may be inhibiting detection of drug intoxication suicides in the United States. We evaluated the relative importance of suicide notes and psychiatric history in the classification of suicide by drug intoxication versus firearm (gunshot wound) plus hanging/suffocation-the other two major, but overtly violent methods. METHODS: This observational multilevel (individual/county), multivariable study employed a generalized linear mixed model (GLMM) to analyze pooled suicides and undetermined intent deaths, as possible suicides, among the population aged 15 years and older in the 17 states participating in the National Violent Death Reporting System throughout 2011-2013...
2018: PloS One
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