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https://www.readbyqxmd.com/read/28453780/variation-in-maturity-onset-diabetes-of-the-young-genes-influence-response-to-interventions-for-diabetes-prevention
#1
Liana K Billings, Kathleen A Jablonski, A Sofia Warner, Yu-Chien Cheng, Jarred B McAteer, Laura Tipton, Alan R Shuldiner, David A Ehrmann, Alisa K Manning, Dana Dabelea, Paul W Franks, Steven E Kahn, Toni I Pollin, William C Knowler, David Altshuler, Jose C Florez
CONTEXT: Variation in genes that cause Maturity-Onset Diabetes of the Young (MODY) has been associated with diabetes incidence and glycemic traits. OBJECTIVES: This study aimed to determine whether genetic variation in MODY genes leads to differential responses to insulin-sensitizing interventions. DESIGN AND SETTING: This was a secondary analysis of a multicenter randomized clinical trial, the Diabetes Prevention Program (DPP), involving 27 U...
April 27, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28448772/the-effect-of-a-federal-controlled-substance-act-schedule-change-on-hydrocodone-combination-products-claims-in-a-medicaid-population
#2
Stephanie Tran, Pavel Lavitas, Karen Stevens, Bonnie C Greenwood, Karen Clements, Caroline J Alper, Kimberly Lenz, Mylissa Price, Tasmina Hydery, Jennifer L Arnold, Mito Takeshita, Rachel Bacon, Justin P Peristere, Paul L Jeffrey
BACKGROUND: In 2012, hydrocodone combination products (HCPs) were the most prescribed medications in the United States. Under the Controlled Substance Act of 1970, hydrocodone alone was classified as a Schedule II drug, while HCPs were classified as Schedule III, indicating a lower risk for abuse and misuse. However, according to a Drug Enforcement Agency analysis, the addition of nonopioids has not been shown to diminish abuse potential of hydrocodone. In response to concerns for drug abuse and overdose, the Drug Enforcement Agency rescheduled HCPs to Schedule II in October 2014, with the intent of limiting overprescribing and increasing awareness of their abuse potential...
May 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28448676/-i-m-still-here-personhood-and-the-early-onset-dementia-experience
#3
Mariko L Sakamoto, Sharon L Moore, Steven T Johnson
Early-onset dementia (EOD) occurs before age 65. The current study examined the lived experience from the point of view of four adults younger than 65 with dementia, particularly how they perceive their personhood. Using interpretative phenomenological analysis as the research approach, findings revealed that the EOD experience can be incorporated into six themes: (a) A Personal Journey, (b) Navigating the System, (c) The Stigma of Dementia, (d) Connecting to the World, (e) A Story Worth Telling, and (f) I'm Still Here...
May 1, 2017: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/28447646/a-130-000-year-old-archaeological-site-in-southern-california-usa
#4
Steven R Holen, Thomas A Deméré, Daniel C Fisher, Richard Fullagar, James B Paces, George T Jefferson, Jared M Beeton, Richard A Cerutti, Adam N Rountrey, Lawrence Vescera, Kathleen A Holen
The earliest dispersal of humans into North America is a contentious subject, and proposed early sites are required to meet the following criteria for acceptance: (1) archaeological evidence is found in a clearly defined and undisturbed geologic context; (2) age is determined by reliable radiometric dating; (3) multiple lines of evidence from interdisciplinary studies provide consistent results; and (4) unquestionable artefacts are found in primary context. Here we describe the Cerutti Mastodon (CM) site, an archaeological site from the early late Pleistocene epoch, where in situ hammerstones and stone anvils occur in spatio-temporal association with fragmentary remains of a single mastodon (Mammut americanum)...
April 26, 2017: Nature
https://www.readbyqxmd.com/read/28445908/diagnosis-of-pulmonary-artery-embolism-comparison-of-single-source-ct-and-3rd-generation-dual-source-ct-using-a-dual-energy-protocol-regarding-image-quality-and-radiation-dose
#5
Bernhard Petritsch, Aleksander Kosmala, Tobias Gassenmaier, Andreas Max Weng, Simon Veldhoen, Andreas Steven Kunz, Thorsten Alexander Bley
Purpose To compare radiation dose, subjective and objective image quality of 3 rd generation dual-source CT (DSCT) and dual-energy CT (DECT) with conventional 64-slice single-source CT (SSCT) for pulmonary CTA. Materials and Methods 180 pulmonary CTA studies were performed in three patient cohorts of 60 patients each. Group 1: conventional SSCT 120 kV (ref.); group 2: single-energy DSCT 100 kV (ref.); group 3: DECT 90/Sn150 kV. CTDIvol, DLP, effective radiation dose were reported, and CT attenuation (HU) was measured on three central and peripheral levels...
April 26, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28445636/disposable-autonomous-device-for-rapid-swab-to-result-diagnosis-of-influenza
#6
Shichu Huang, Koji Abe, Steven Bennett, Tinny Liang, Paula D Ladd, Lindsay Yokobe, Caitlin E Anderson, Kamal Shah, Josh Bishop, Mike Purfield, Peter C Kauffman, Sai Paul, AnneMarie E Welch, Bonnie Strelitz, Kristin Follmer, Kelsey Pullar, Luis Sanchez-Erebia, Emily Gerth-Guyette, Gonzalo J Domingo, Eileen Klein, Janet A Englund, Elain Fu, Paul Yager
A prototype of a self-contained, automated, disposable device for chemically-amplified protein-based detection of influenza virus from nasal swab specimens was developed and evaluated in a clinical setting. The device required only simple specimen manipulation without any dedicated instrumentation or specialized training by the operator for interpretation. The device was based on a sandwich immunoassay for influenza virus nucleoprotein; it used an enzyme-labeled antibody and a chromogenic substrate to provide an amplified visible signal, in a two-dimensional paper network format...
April 26, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28445107/hypodermal-adipose-tissue-sonoelastography-for-monitoring-treatment-response-in-patients-with-plaque-psoriasis
#7
Annunziata Dattola, Simone Altobelli, Salvatore Marsico, Domenico Plastina, Steven P Nistico, Armando Cavallo, Roberto Floris, Luca Bianchi, Manlio Guazzaroni
BACKGROUND: Psoriasis (PsO) is a multifactorial chronic and relapsing skin disease that affects about 125 million people in the world. Several studies have demonstrated the link between adipose tissue, inflammation, and PsO. The purpose of our study is to evaluate hypodermal adipose tissue inflammation underneath PsO plaques quantifying tissue elasticity with sonoelastography before and after treatment. The study was conducted at the Department of Dermatology of the University of "Rome Tor Vergata" and Department of Radiology of the University of "Rome Tor Vergata...
April 24, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28445000/vegetation-response-to-control-of-invasive-tamarix-in-southwestern-us-rivers-a-collaborative-study-including-416-sites
#8
Eduardo González, Anna A Sher, Robert M Anderson, Robin F Bay, Daniel W Bean, Gabriel J Bissonnete, Bérenger Bourgeois, David J Cooper, Kara Dohrenwend, Kim D Eichhorst, Hisham El Waer, Deborah K Kennard, Rebecca Harms-Weissinger, Annie L Henry, Lori J Makarick, Steven M Ostoja, Lindsay V Reynolds, W Wright Robinson, Patrick B Shafroth
Most studies assessing vegetation response following control of invasive Tamarix trees along southwestern U.S. rivers have been small in scale (e.g., river reach), or at a regional scale but with poor spatial-temporal replication, and most have not included testing the effects of a now widely-used biological control. We monitored plant composition following Tamarix control along hydrologic, soil and climatic gradients in 244 treated and 172 reference sites across six U.S. States. This represents the largest comprehensive assessment to date on the vegetation response to the four most common Tamarix control treatments...
April 26, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28443337/inhaled-nanoparticles-accumulate-at-sites-of-vascular-disease
#9
Mark R Miller, Jennifer B Raftis, Jeremy P Langrish, Steven G McLean, Pawitrabhorn Samutrtai, Shea P Connell, Simon Wilson, Alex T Vesey, Paul H B Fokkens, A John F Boere, Petra Krystek, Colin J Campbell, Patrick W F Hadoke, Ken Donaldson, Flemming R Cassee, David E Newby, Rodger Duffin, Nicholas L Mills
The development of engineered nanomaterials is growing exponentially, despite concerns over their potential similarities to environmental nanoparticles that are associated with significant cardiorespiratory morbidity and mortality. The mechanisms through which inhalation of nanoparticles could trigger acute cardiovascular events are emerging, but a fundamental unanswered question remains: Do inhaled nanoparticles translocate from the lung in man and directly contribute to the pathogenesis of cardiovascular disease? In complementary clinical and experimental studies, we used gold nanoparticles to evaluate particle translocation, permitting detection by high-resolution inductively coupled mass spectrometry and Raman microscopy...
April 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28443096/the-microbiota-and-epigenetic-regulation-of-t-helper-17-regulatory-t-cells-in-search-of-a-balanced-immune-system
#10
REVIEW
Annie Luo, Steven T Leach, Romain Barres, Luke B Hesson, Michael C Grimm, David Simar
Immune cells not only affect tissue homeostasis at the site of inflammation but also exert systemic effects contributing to multiple chronic conditions. Recent evidence clearly supports an altered T helper 17/regulatory T cell (Th17/Treg) balance leading to the development and progression of inflammatory diseases that not only affect the gastrointestinal tract but also have whole-body manifestations, including insulin resistance. Epigenetic mechanisms are amenable to both environmental and circulating factors and contribute to determining the T cell landscape...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28442455/use-of-fitness-and-nutrition-apps-associations-with-body-mass-index-snacking-and-drinking-habits-in-adolescents
#11
Nathalie De Cock, Jolien Vangeel, Carl Lachat, Kathleen Beullens, Leentje Vervoort, Lien Goossens, Lea Maes, Benedicte Deforche, Stefaan De Henauw, Caroline Braet, Steven Eggermont, Patrick Kolsteren, John Van Camp, Wendy Van Lippevelde
BACKGROUND: Efforts to improve snacking and drinking habits are needed to promote a healthy body mass index (BMI) in adolescents. Although commercial fitness and nutrition mobile phone apps are widely used, little is known regarding their potential to improve health behaviors, especially in adolescents. In addition, evidence on the mechanisms through which such fitness and nutrition apps influence behavior is lacking. OBJECTIVES: This study assessed whether the use of commercial fitness or nutrition apps was associated with a lower BMI and healthier snacking and drinking habits in adolescents...
April 25, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28441176/long-term-nitrite-inhalant-exposure-and-cancer-risk-in-msm
#12
Anupriya Dutta, Hajime Uno, Alex Holman, David R Lorenz, Steven M Wolinsky, Dana Gabuzda
OBJECTIVES: Nitrite inhalants (poppers) are commonly used recreational drugs among MSM and were previously associated with elevated rates of high-risk sexual behavior, HIV and human herpesvirus type 8 (HHV-8) seroconversion, and transient immunosuppressive effects in experimental models. Whether long-term popper use is associated with cancer risk among MSM in the HAART era is unclear. DESIGN: Prospective cohort study of cancer risk in 3223 HIV-infected and uninfected MSM in the Multicenter AIDS Cohort Study from 1996-2010...
May 15, 2017: AIDS
https://www.readbyqxmd.com/read/28440597/external-quality-assessment-for-laboratory-testing-of-hla-b-15-02-allele-in-relation-to-carbamazepine-therapy
#13
Guigao Lin, Kuo Zhang, Yanxi Han, Jiehong Xie, Jinming Li
BACKGROUND: Due to the significant risk of developing Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), the use of carbamazepine is not recommended in patients carrying the human leukocyte antigen B (HLA-B) *15:02 allele. In an effort to guarantee reliable community-based HLA-B*15:02 testing throughout China, a HLA-B*15:02 genotyping external quality assessment (EQA) program was set up. METHODS: In 2016, 10 genomic DNA samples with known HLA-B*15:02 allele status were sent to 37 laboratories from 16 provinces with a request for routine HLA-B*15:02 screening...
April 25, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28439251/when-a-fly-ball-is-out-of-reach-catchability-judgments-are-not-based-on-optical-acceleration-cancelation
#14
Dees B W Postma, Joanne Smith, Gert-Jan Pepping, Steven van Andel, Frank T J M Zaal
The optical acceleration cancelation (OAC) strategy, based on Chapman's (1968) analysis of the outfielder problem, has been the dominant account for the control of running to intercept fly balls approaching head on. According to the OAC strategy, outfielders will arrive at the interception location just in time to catch the ball when they keep optical acceleration zero. However, the affordance aspect of this task, that is, whether or not an approaching fly ball is catchable, is not part of this account. The present contribution examines whether the scope of the OAC strategy can be extended to also include the affordance aspect of running to catch a fly ball...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28438875/a-new-prognostic-instrument-specifically-designed-for-patients-irradiated-for-recurrent-carcinoma-of-the-bladder
#15
Lisa Manig, Stefan Janssen, Steven E Schild, Dirk Rades
BACKGROUND/AIM: To develop an instrument that could estimate the 1-year survival probabilities of patients irradiated for recurrent carcinoma of the bladder. PATIENTS AND METHODS: Thirty patients irradiated for locally recurrent bladder carcinoma were included. Six pre-treatment factors [age, gender, Karnofsky score (KPS), pack years, grading and time between cancer diagnosis and radiotherapy] were evaluated for survival. Of those factors showing a trend or significance on multivariate analysis, 1-year survival rates were added...
May 2017: In Vivo
https://www.readbyqxmd.com/read/28438616/pericytic-tumors-of-the-kidney-a-clinicopathologic-analysis-of-17-cases
#16
Deepika Sirohi, Steven C Smith, Jonathan I Epstein, Bonnie L Balzer, Jeffry P Simko, Dana Balitzer, Jamal Benhamida, Oleksandr N Kryvenko, Nilesh S Gupta, Swetha Paluru, Isabela Werneck da Cunha, Daniel N Leal, Sean R Williamson, Mariza de Peralta-Venturina, Mahul B Amin
The pericytic (perivascular myoid cell) family of tumors is a distinctive group of mesenchymal neoplasms encountered in superficial sites and only rarely seen in viscera. The pericytic family subtends a spectrum of lesions, namely, glomus tumors and variants; myopericytoma, including myofibroma; and angioleiomyoma. In light of the contemporary classification of pericytic lesions, we identified and reviewed 17 cases of renal pericytic tumors from the files of 6 referral centers. These tumors presented over an age range of 17 to 76years (mean 46...
April 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28437162/adjuvant-systemic-therapy-and-adjuvant-radiation-therapy-for-stage-i-to-iiia-completely-resected-non-small-cell-lung-cancers-american-society-of-clinical-oncology-cancer-care-ontario-clinical-practice-guideline-update
#17
Mark G Kris, Laurie E Gaspar, Jamie E Chaft, Erin B Kennedy, Christopher G Azzoli, Peter M Ellis, Steven H Lin, Harvey I Pass, Rahul Seth, Frances A Shepherd, David R Spigel, John R Strawn, Yee C Ung, Michael Weyant
Purpose The panel updated the American Society of Clinical Oncology (ASCO) adjuvant therapy guideline for resected non-small-cell lung cancers. Methods ASCO convened an update panel and conducted a systematic review of the literature, investigating adjuvant therapy in resected non-small-cell lung cancers. Results The updated evidence base covered questions related to adjuvant systemic therapy and included a systematic review conducted by Cancer Care Ontario current to January 2016. A recent American Society for Radiation Oncology guideline and systematic review, previously endorsed by ASCO, was used as the basis for recommendations for adjuvant radiation therapy...
April 24, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28436989/corrigendum-the-clinically-approved-antiviral-drug-sofosbuvir-inhibits-zika-virus-replication
#18
Carolina Q Sacramento, Gabrielle R de Melo, Caroline S de Freitas, Natasha Rocha, Lucas Villas Bôas Hoelz, Milene Miranda, Natalia Fintelman-Rodrigues, Andressa Marttorelli, André C Ferreira, Giselle Barbosa-Lima, Juliana L Abrantes, Yasmine Rangel Vieira, Mônica M Bastos, Eduardo de Mello Volotão, Estevão Portela Nunes, Diogo A Tschoeke, Luciana Leomil, Erick Correia Loiola, Pablo Trindade, Stevens K Rehen, Fernando A Bozza, Patrícia T Bozza, Nubia Boechat, Fabiano L Thompson, Ana M B de Filippis, Karin Brüning, Thiago Moreno L Souza
No abstract text is available yet for this article.
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28436149/transgenic-mir156-switchgrass-in-the-field-growth-recalcitrance-and-rust-susceptibility
#19
Holly L Baxter, Mitra Mazarei, Alexandru Dumitrache, Jace Natzke, Miguel Rodriguez, Jiqing Gou, Chunxiang Fu, Robert W Sykes, Geoffrey B Turner, Mark F Davis, Steven Brown, Brian Davison, Zeng-Yu Wang, C Neal Stewart
Sustainable utilization of lignocellulosic perennial grass feedstocks will be enabled by high biomass production and optimized cell wall chemistry for efficient conversion into biofuels. MicroRNAs are regulatory elements that modulate the expression of genes involved in various biological functions in plants, including growth and development. In greenhouse studies, overexpressing a microRNA (miR156) gene in switchgrass had dramatic effects on plant architecture and flowering, which appeared to be driven by transgene expression levels...
April 24, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28435342/patient-web-portals-disease-management-and-primary-prevention
#20
REVIEW
Steven S Coughlin, Judith J Prochaska, Lovoria B Williams, Gina M Besenyi, Vahé Heboyan, D Stephen Goggans, Wonsuk Yoo, Gianluca De Leo
BACKGROUND: Efforts aimed at health care reform and continued advances in information technologies have prompted interest among providers and researchers in patient web portals. Patient web portals are password-protected online websites that offer the patients 24-hour access to personal health information from anywhere with an Internet connection. METHODS: This article, which is based upon bibliographic searches in PubMed, reviews important developments in web portals for primary and secondary disease prevention, including patient web portals tethered to electronic medical records, disease-specific portals, health disparities, and health-related community web portals...
2017: Risk Management and Healthcare Policy
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