keyword
https://read.qxmd.com/read/38630846/host-microbe-multiomic-profiling-reveals-age-dependent-immune-dysregulation-associated-with-covid-19-immunopathology
#1
JOURNAL ARTICLE
Hoang Van Phan, Alexandra Tsitsiklis, Cole P Maguire, Elias K Haddad, Patrice M Becker, Seunghee Kim-Schulze, Brian Lee, Jing Chen, Annmarie Hoch, Harry Pickering, Patrick van Zalm, Matthew C Altman, Alison D Augustine, Carolyn S Calfee, Steve Bosinger, Charles B Cairns, Walter Eckalbar, Leying Guan, Naresh Doni Jayavelu, Steven H Kleinstein, Florian Krammer, Holden T Maecker, Al Ozonoff, Bjoern Peters, Nadine Rouphael, Ruth R Montgomery, Elaine Reed, Joanna Schaenman, Hanno Steen, Ofer Levy, Joann Diray-Arce, Charles R Langelier
Age is a major risk factor for severe coronavirus disease 2019 (COVID-19), yet the mechanisms behind this relationship have remained incompletely understood. To address this, we evaluated the impact of aging on host immune response in the blood and the upper airway, as well as the nasal microbiome in a prospective, multicenter cohort of 1031 vaccine-naïve patients hospitalized for COVID-19 between 18 and 96 years old. We performed mass cytometry, serum protein profiling, anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody assays, and blood and nasal transcriptomics...
April 17, 2024: Science Translational Medicine
https://read.qxmd.com/read/38630246/implementation-of-the-mind-youth-questionnaire-my-q-for-routine-health-related-quality-of-life-screening-of-adolescents-with-type-1-diabetes-in-a-large-tertiary-care-center
#2
JOURNAL ARTICLE
Aleksandra Stojanova, Mary-Ann Harrison, Nicholas Mitsakakis, Zoyah Thawer, Nardin Kirolos, Liz Stevens, Jolianne Paul, Christine Richardson, Caroline Zuijdwijk, Ellen B Goldbloom, Sarah Lawrence, Marie-Eve Robinson, Alexandra Ahmet
OBJECTIVES: Prevalence of diabetes distress and mental health comorbidities among adolescents with type 1 diabetes (T1D) is high. Despite recommendations for routine psychosocial risk assessment, there is little guidance for their implementation. This study aims to describe the implementation and baseline outcomes of the Mind Youth Questionnaire (MY-Q), a validated psychosocial screening tool for health-related quality of life (QoL) including mood, among adolescents living with T1D. METHODS: Adolescents aged 13-18 years completed the MY-Q from October 1, 2019-April 1, 2023...
April 18, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/38629258/off-label-prescribing-of-immune-checkpoint-inhibitor-therapy-at-a-single-pediatric-cancer-center
#3
JOURNAL ARTICLE
Ajami Gikandi, Susan N Chi, Kee Kiat Yeo, Allison F O'Neill, David S Shulman, Steven G DuBois, Natalie B Collins
BACKGROUND: Immune checkpoint inhibitors (ICI) have improved outcomes in a variety of adult cancers and are prescribed with increasing frequency across oncology. However, patterns of off-label use of ICI in pediatrics remain unclear. METHODS: This is a single-institution, retrospective cohort study evaluating off-label ICI use in pediatric and young adult patients with cancer treated at our institution from 2014 to 2022. Response was based on clinician assessment derived from clinical records...
April 2024: Cancer Medicine
https://read.qxmd.com/read/38629074/donor-kir-genotype-based-outcome-prediction-after-allogeneic-stem-cell-transplantation-no-land-in-sight
#4
JOURNAL ARTICLE
Johannes Schetelig, Henning Baldauf, Falk Heidenreich, Jorinde D Hoogenboom, Stephen R Spellman, Alexander Kulagin, Thomas Schroeder, Henrik Sengeloev, Peter Dreger, Edouard Forcade, Jan Vydra, Eva Maria Wagner-Drouet, Goda Choi, Shankara Paneesha, Nuno A A Miranda, Alina Tanase, Liesbeth C de Wreede, Vinzenz Lange, Alexander H Schmidt, Jürgen Sauter, Joshua A Fein, Yung-Tsi Bolon, Meilun He, Steven G E Marsh, Shahinaz M Gadalla, Sophie Paczesny, Annalisa Ruggeri, Christian Chabannon, Katharina Fleischhauer
Optimizing natural killer (NK) cell alloreactivity could further improve outcome after allogeneic hematopoietic cell transplantation (alloHCT). The donor's Killer-cell Immunoglobulin-like Receptor (KIR) genotype may provide important information in this regard. In the past decade, different models have been proposed aiming at maximizing NK cell activation by activating KIR-ligand interactions or minimizing inhibitory KIR-ligand interactions. Alternative classifications intended predicting outcome after alloHCT by donor KIR-haplotypes...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38628297/pediatric-pulmonary-milestones-2-0-development-lessons-learned-and-future-directions
#5
JOURNAL ARTICLE
Laura E Chiel, Erica L Stevens, Lara C Bishay, Melanie S Collins, Jennifer A Rama, Laura Edgar, Sydney McLean, Ida Haynes, Hiren Muzumdar, Pnina Weiss, Debra Boyer, B Louise Giles
Pediatric pulmonology fellowship training programs are required by the Accreditation Council for Graduate Medical Education to report Pediatric Subspecialty Milestones biannually to track fellow progress. However, several issues, such as lack of subspecialty-specific context and ambiguous language, have raised concerns about their validity and applicability to use for fellow assessment and curriculum development. In this Perspective, we briefly share the process of the Pediatric Pulmonology Milestones 2.0 Work Group in creating new specialty-specific Milestones and tailoring information on the Harmonized Milestones to pediatric pulmonologists, with the goal of improving the Milestones' utility for stakeholders, including pulmonology fellows, faculty, program directors, and accrediting bodies...
March 2024: ATS scholar
https://read.qxmd.com/read/38627910/autophagy-gene-expression-in-skeletal-muscle-of-older-individuals-is-associated-with-physical-performance-muscle-volume-and-mitochondrial-function-in-the-study-of-muscle-mobility-and-aging-somma
#6
JOURNAL ARTICLE
Paul M Coen, Zhiguang Huo, Gregory J Tranah, Haley N Barnes, Xiping Zhang, Christopher A Wolff, Kevin Wu, Peggy M Cawthon, Russell T Hepple, Frederico G S Toledo, Daniel S Evans, Olaya Santiago-Fernández, Ana Maria Cuervo, Stephen B Kritchevsky, Anne B Newman, Steven R Cummings, Karyn A Esser
Autophagy is essential for proteostasis, energetic balance, and cell defense and is a key pathway in aging. Identifying associations between autophagy gene expression patterns in skeletal muscle and physical performance outcomes would further our knowledge of mechanisms related with proteostasis and healthy aging. Muscle biopsies were obtained from participants in the Study of Muscle, Mobility, and Aging (SOMMA). For 575 participants, RNA was sequenced and expression of 281 genes related to autophagy regulation, mitophagy, and mTOR/upstream pathways was determined...
April 16, 2024: Aging Cell
https://read.qxmd.com/read/38627253/accuracy-of-magnetic-resonance-imaging-ultrasound-fusion-guided-and-systematic-biopsy-of-the-prostate
#7
JOURNAL ARTICLE
Thomas In de Braekt, Sanne B T van Rooij, Alette W Daniels-Gooszen, Wout A Scheepens, Rik de Jongh, Steven L Bosch, Joost Nederend
OBJECTIVES: Prostate multiparametric magnetic resonance imaging (mpMRI) with subsequent targeted biopsy of suspicious lesions have a critical role in the diagnostic workup of prostate cancer. The objective was to evaluate the diagnostic accuracy of systematic biopsies, targeted biopsies, and the combination of both in prostate cancer detection. METHODS: From 1-1-2013 to 1-6-2022, biopsy-naïve and prior biopsy-negative patients who underwent both systematic and targeted biopsies were included...
April 16, 2024: British Journal of Radiology
https://read.qxmd.com/read/38622998/high-risk-escherichia-coli-clones-that-cause-neonatal-meningitis-and-association-with-recrudescent-infection
#8
JOURNAL ARTICLE
Nguyen Thi Khanh Nhu, Minh-Duy Phan, Steven J Hancock, Kate M Peters, Laura Alvarez-Fraga, Brian M Forde, Stacey B Andersen, Thyl Miliya, Patrick N A Harris, Scott A Beatson, Sanmarie Schlebusch, Haakon Bergh, Paul Turner, Annelie Brauner, Benita Westerlund-Wikström, Adam D Irwin, Mark A Schembri
Neonatal meningitis is a devastating disease associated with high mortality and neurological sequelae. Escherichia coli is the second most common cause of neonatal meningitis in full-term infants (herein NMEC) and the most common cause of meningitis in preterm neonates. Here, we investigated the genomic relatedness of a collection of 58 NMEC isolates spanning 1974-2020 and isolated from seven different geographic regions. We show NMEC are comprised of diverse sequence types (STs), with ST95 (34.5%) and ST1193 (15...
April 16, 2024: ELife
https://read.qxmd.com/read/38621216/growing-project-bioeyes-a-reflection-on-20-years-of-developing-and-replicating-a-k-12-science-outreach-program
#9
JOURNAL ARTICLE
Jamie R Shuda, Valerie G Butler, Theresa M Nelson, Jaqueline M Davidson, Auset M Taylor, Steven A Farber
Project BioEYES celebrated 20 years in K12 schools during the 2022-2023 school year. Using live zebrafish ( Danio rerio ) during week-long science experiments, sparks the interest of students and teachers from school districts, locally and globally. Over the past two decades, BioEYES has been replicated in different ways based on the interest and capacity of our partners. This article discusses several of the successful models, the common challenges, and how each BioEYES site has adopted guiding principles to help foster their success...
April 2024: Zebrafish
https://read.qxmd.com/read/38621114/the-development-and-feasibility-of-a-novel-group-intervention-to-support-helping-professionals-in-metabolizing-suffering-and-engaging-strengths-the-chrysalis-program
#10
JOURNAL ARTICLE
Laura E Captari, Elise Ji Young Choe, Sarah A Crabtree, Steven J Sandage, Judith A Gerstenblith, Laura B Stein, Kristen R Hydinger, George Stavros
This feasibility study reports on the development and initial evaluation of a novel online intervention for helping professionals (HPs; i.e. mental health professionals, chaplains, clergy) designed to (a) address occupational hazards, such as burnout and vicarious traumatization, and (b) promote well-being and flourishing at work. In contrast with competency and self-care focused models, the CHRYSALIS (Catalyzing Helping Professionals' Resilience, VitalitY, Spirituality, Authentic Living, and Inner Strength) intervention centers the self of the provider, explores cultural and spiritual contexts, and attends to systemic challenges...
April 15, 2024: International Journal of Group Psychotherapy
https://read.qxmd.com/read/38619945/same-data-diverging-perspectives-the-power-of-visualizations-to-elicit-competing-interpretations
#11
JOURNAL ARTICLE
Cindy Xiong Bearfield, Lisanne van Weelden, Adam Waytz, Steven Franconeri
People routinely rely on data to make decisions, but the process can be riddled with biases. We show that patterns in data might be noticed first or more strongly, depending on how the data is visually represented or what the viewer finds salient. We also demonstrate that viewer interpretation of data is similar to that of 'ambiguous figures' such that two people looking at the same data can come to different decisions. In our studies, participants read visualizations depicting competitions between two entities, where one has a historical lead (A) but the other has been gaining momentum (B) and predicted a winner, across two chart types and three annotation approaches...
April 15, 2024: IEEE Transactions on Visualization and Computer Graphics
https://read.qxmd.com/read/38619214/an-updated-assessment-of-hepatitis-delta-prevalence-among-adults-in-canada-a-meta-analysis
#12
JOURNAL ARTICLE
Robert J Wong, Grishma Hirode, Jordan Feld, Steven S Wong, Carol Brosgart, Jeffrey Glenn, Saeed Hamid, Chari Cohen, Beatrice Zovich, John Ward, Heiner Wedemeyer, Cihan Yurdaydin, Robert Gish
Foreign-born (FB) persons represent a large proportion of adults with chronic hepatitis B (CHB) in Canada due to higher prevalence rates in countries of birth for FB persons. Suboptimal awareness and low rates of hepatitis delta virus (HDV) testing contribute to underdiagnosis and gaps in accurate estimates of Canada HDV prevalence. We aim to provide an assessment of CHB and HDV prevalence in Canada using a comprehensive literature review and meta-analysis. A comprehensive literature review of articles reporting HBsAg seroprevalence and anti-HDV prevalence was conducted to calculate country-specific rates and pooled prevalence of CHB and HDV using meta-analyses...
April 15, 2024: Journal of Viral Hepatitis
https://read.qxmd.com/read/38618730/current-and-future-states-of-natural-killer-cell-based-immunotherapy-in-hepatocellular-carcinoma
#13
JOURNAL ARTICLE
Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven S Raman, Anahid Jewett, Jason Chiang
Natural killer (NK) cells are innate lymphoid cells that exhibit high levels of cytotoxicity against NK-specific targets. NK cells also produce various cytokines, and interact with T cells, B cells, and dendritic cells to effectively serve as frontliners of the innate immune system. Produce various cytokines, and interact with T cells, B cells, and dendritic cells to effectively serve as frontliners of the innate immune system. Moreover, NK cells constitute the second most common immune cell in the liver. These properties have drawn significant attention towards leveraging NK cells in treating liver cancer, especially hepatocellular carcinoma (HCC), which accounts for 75% of all primary liver cancer and is the fourth leading cause of cancer-related death worldwide...
2024: Critical Reviews in Immunology
https://read.qxmd.com/read/38617802/3-4-ethylenedioxythiophene-hydrogels-relating-structure-and-charge-transport-in-supramolecular-gels
#14
JOURNAL ARTICLE
Luke C B Salter, Jonathan P Wojciechowski, Ben McLean, Patrick Charchar, Piers R F Barnes, Adam Creamer, James Doutch, Hanna M G Barriga, Margaret N Holme, Irene Yarovsky, Molly M Stevens
Ionic charge transport is a ubiquitous language of communication in biological systems. As such, bioengineering is in constant need of innovative, soft, and biocompatible materials that facilitate ionic conduction. Low molecular weight gelators (LMWGs) are complex self-assembled materials that have received increasing attention in recent years. Beyond their biocompatible, self-healing, and stimuli responsive facets, LMWGs can be viewed as a "solid" electrolyte solution. In this work, we investigate 3,4-ethylenedioxythiophene (EDOT) as a capping group for a small peptide library, which we use as a system to understand the relationship between modes of assembly and charge transport in supramolecular gels...
April 9, 2024: Chemistry of Materials: a Publication of the American Chemical Society
https://read.qxmd.com/read/38616258/mitovesicles-secreted-into-the-extracellular-space-of-brains-with-mitochondrial-dysfunction-impair-synaptic-plasticity
#15
JOURNAL ARTICLE
Pasquale D'Acunzo, Elentina K Argyrousi, Jonathan M Ungania, Yohan Kim, Steven DeRosa, Monika Pawlik, Chris N Goulbourne, Ottavio Arancio, Efrat Levy
BACKGROUND: Hypometabolism tied to mitochondrial dysfunction occurs in the aging brain and in neurodegenerative disorders, including in Alzheimer's disease, in Down syndrome, and in mouse models of these conditions. We have previously shown that mitovesicles, small extracellular vesicles (EVs) of mitochondrial origin, are altered in content and abundance in multiple brain conditions characterized by mitochondrial dysfunction. However, given their recent discovery, it is yet to be explored what mitovesicles regulate and modify, both under physiological conditions and in the diseased brain...
April 14, 2024: Molecular Neurodegeneration
https://read.qxmd.com/read/38615976/sex-based-differences-in-concomitant-tricuspid-repair-during-degenerative-mitral-surgery
#16
JOURNAL ARTICLE
Catherine M Wagner, Whitney Fu, Alexander A Brescia, Jessica Woodford, China Green, Donald S Likosky, Robert B Hawkins, Matthew A Romano, Gorav Ailawadi, Steven F Bolling
BACKGROUND: Females with mitral valve disease have higher rates of tricuspid regurgitation(TR) than males. While tricuspid valve repair(TVr) decreases progression of TR, we hypothesize that there may be sex-based differences in concomitant TVr at the time of mitral surgery. METHODS: Adults undergoing mitral surgery for degenerative disease with moderate or worse preoperative TR at a high-volume center from 2014-2023 were identified. Patients with previous tricuspid intervention were excluded...
April 12, 2024: Annals of Thoracic Surgery
https://read.qxmd.com/read/38615789/perinatal-exposure-to-polychlorinated-biphenyls-pcbs-and-child-neurodevelopment-a-comprehensive-systematic-review-of-outcomes-and-methodological-approaches
#17
REVIEW
Arin A Balalian, Jeanette A Stingone, Linda G Kahn, Julie B Herbstman, Richard I Graeve, Steven D Stellman, Pam Factor-Litvak
BACKGROUND: Polychlorinated biphenyls (PCBs), extensively used in various products, prompt ongoing concern despite reduced exposure since the 1970s. This systematic review explores prenatal PCB and hydroxylated metabolites (OH-PCBs) exposure's association with child neurodevelopment. Encompassing cognitive, motor development, behavior, attention, ADHD, and ASD risks, it also evaluates diverse methodological approaches in studies. METHODS: PubMed, Embase, PsycINFO, and Web of Science databases were searched through August 23, 2023, by predefined search strings...
April 12, 2024: Environmental Research
https://read.qxmd.com/read/38614387/three-year-outcomes-of-valoctocogene-roxaparvovec-gene-therapy-for-hemophilia-a
#18
JOURNAL ARTICLE
Bella Madan, Margareth C Ozelo, Priyanka Raheja, Emily Symington, Doris V Quon, Andrew D Leavitt, Steven W Pipe, Gillian Lowe, Gili Kenet, Mark T Reding, Jane Mason, Michael Wang, Annette von Drygalski, Robert Klamroth, Susan Shapiro, Hervé Chambost, Amy L Dunn, Johannes Oldenburg, Sheng-Chieh Chou, Flora Peyvandi, Carolyn M Millar, Dane Osmond, Hua Yu, Ebony Dashiell-Aje, Tara M Robinson, Johnny Mahlangu
BACKGROUND: Valoctocogene roxaparvovec transfers a human factor VIII (FVIII) coding sequence into hepatocytes of people with severe hemophilia A to provide bleeding protection. OBJECTIVE: Present 3-year efficacy and safety in the multicenter, open-label, single-arm, phase 3 GENEr8-1 trial. METHODS: GENEr8-1 enrolled 134 adult males with severe hemophilia A who were receiving FVIII prophylaxis. Efficacy endpoints included annualized bleeding rate (ABR), annualized FVIII utilization (AFU), FVIII activity (chromogenic substrate assay; imputed as 1 IU/dL at baseline and 0 IU/dL after discontinuation), and the Haemophilia-Specific Quality of Life Questionnaire for Adults (Haemo-QOL-A)...
April 11, 2024: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/38613276/amplitude-analysis-of-the-b-0-%C3%A2-k-0-%C3%AE-%C3%AE-decay
#19
JOURNAL ARTICLE
R Aaij, A S W Abdelmotteleb, C Abellan Beteta, F Abudinén, T Ackernley, B Adeva, M Adinolfi, P Adlarson, C Agapopoulou, C A Aidala, Z Ajaltouni, S Akar, K Akiba, P Albicocco, J Albrecht, F Alessio, M Alexander, A Alfonso Albero, Z Aliouche, P Alvarez Cartelle, R Amalric, S Amato, J L Amey, Y Amhis, L An, L Anderlini, M Andersson, A Andreianov, P Andreola, M Andreotti, D Andreou, A Anelli, D Ao, F Archilli, M Argenton, S Arguedas Cuendis, A Artamonov, M Artuso, E Aslanides, M Atzeni, B Audurier, D Bacher, I Bachiller Perea, S Bachmann, M Bachmayer, J J Back, A Bailly-Reyre, P Baladron Rodriguez, V Balagura, W Baldini, J Baptista de Souza Leite, M Barbetti, I R Barbosa, R J Barlow, S Barsuk, W Barter, M Bartolini, F Baryshnikov, J M Basels, G Bassi, B Batsukh, A Battig, A Bay, A Beck, M Becker, F Bedeschi, I B Bediaga, A Beiter, S Belin, V Bellee, K Belous, I Belov, I Belyaev, G Benane, G Bencivenni, E Ben-Haim, A Berezhnoy, R Bernet, S Bernet Andres, H C Bernstein, C Bertella, A Bertolin, C Betancourt, F Betti, J Bex, Ia Bezshyiko, J Bhom, M S Bieker, N V Biesuz, P Billoir, A Biolchini, M Birch, F C R Bishop, A Bitadze, A Bizzeti, M P Blago, T Blake, F Blanc, J E Blank, S Blusk, D Bobulska, V Bocharnikov, J A Boelhauve, O Boente Garcia, T Boettcher, A Bohare, A Boldyrev, C S Bolognani, R Bolzonella, N Bondar, F Borgato, S Borghi, M Borsato, J T Borsuk, S A Bouchiba, T J V Bowcock, A Boyer, C Bozzi, M J Bradley, S Braun, A Brea Rodriguez, N Breer, J Brodzicka, A Brossa Gonzalo, J Brown, D Brundu, A Buonaura, L Buonincontri, A T Burke, C Burr, A Bursche, A Butkevich, J S Butter, J Buytaert, W Byczynski, S Cadeddu, H Cai, R Calabrese, L Calefice, S Cali, M Calvi, M Calvo Gomez, J Cambon Bouzas, P Campana, D H Campora Perez, A F Campoverde Quezada, S Capelli, L Capriotti, R Caravaca-Mora, A Carbone, L Carcedo Salgado, R Cardinale, A Cardini, P Carniti, L Carus, A Casais Vidal, R Caspary, G Casse, J Castro Godinez, M Cattaneo, G Cavallero, V Cavallini, S Celani, J Cerasoli, D Cervenkov, S Cesare, A J Chadwick, I Chahrour, M Charles, Ph Charpentier, C A Chavez Barajas, M Chefdeville, C Chen, S Chen, A Chernov, S Chernyshenko, V Chobanova, S Cholak, M Chrzaszcz, A Chubykin, V Chulikov, P Ciambrone, M F Cicala, X Cid Vidal, G Ciezarek, P Cifra, P E L Clarke, M Clemencic, H V Cliff, J Closier, J L Cobbledick, C Cocha Toapaxi, V Coco, J Cogan, E Cogneras, L Cojocariu, P Collins, T Colombo, A Comerma-Montells, L Congedo, A Contu, N Cooke, I Corredoira, A Correia, G Corti, J J Cottee Meldrum, B Couturier, D C Craik, M Cruz Torres, R Currie, C L Da Silva, S Dadabaev, L Dai, X Dai, E Dall'Occo, J Dalseno, C D'Ambrosio, J Daniel, A Danilina, P d'Argent, A Davidson, J E Davies, A Davis, O De Aguiar Francisco, C De Angelis, J de Boer, K De Bruyn, S De Capua, M De Cian, U De Freitas Carneiro Da Graca, E De Lucia, J M De Miranda, L De Paula, M De Serio, D De Simone, P De Simone, F De Vellis, J A de Vries, F Debernardis, D Decamp, V Dedu, L Del Buono, B Delaney, H-P Dembinski, J Deng, V Denysenko, O Deschamps, F Dettori, B Dey, P Di Nezza, I Diachkov, S Didenko, S Ding, V Dobishuk, A D Docheva, A Dolmatov, C Dong, A M Donohoe, F Dordei, A C Dos Reis, L Douglas, A G Downes, W Duan, P Duda, M W Dudek, L Dufour, V Duk, P Durante, M M Duras, J M Durham, A Dziurda, A Dzyuba, S Easo, E Eckstein, U Egede, A Egorychev, V Egorychev, C Eirea Orro, S Eisenhardt, E Ejopu, S Ek-In, L Eklund, M Elashri, J Ellbracht, S Ely, A Ene, E Epple, S Escher, J Eschle, S Esen, T Evans, F Fabiano, L N Falcao, Y Fan, B Fang, L Fantini, M Faria, K Farmer, D Fazzini, L Felkowski, M Feng, M Feo, M Fernandez Gomez, A D Fernez, F Ferrari, F Ferreira Rodrigues, S Ferreres Sole, M Ferrillo, M Ferro-Luzzi, S Filippov, R A Fini, M Fiorini, M Firlej, K M Fischer, D S Fitzgerald, C Fitzpatrick, T Fiutowski, F Fleuret, M Fontana, F Fontanelli, L F Foreman, R Forty, D Foulds-Holt, M Franco Sevilla, M Frank, E Franzoso, G Frau, C Frei, D A Friday, L Frontini, J Fu, Q Fuehring, Y Fujii, T Fulghesu, E Gabriel, G Galati, M D Galati, A Gallas Torreira, D Galli, S Gambetta, M Gandelman, P Gandini, H Gao, R Gao, Y Gao, Y Gao, Y Gao, M Garau, L M Garcia Martin, P Garcia Moreno, J García Pardiñas, B Garcia Plana, K G Garg, L Garrido, C Gaspar, R E Geertsema, L L Gerken, E Gersabeck, M Gersabeck, T Gershon, Z Ghorbanimoghaddam, L Giambastiani, F I Giasemis, V Gibson, H K Giemza, A L Gilman, M Giovannetti, A Gioventù, P Gironella Gironell, C Giugliano, M A Giza, E L Gkougkousis, F C Glaser, V V Gligorov, C Göbel, E Golobardes, D Golubkov, A Golutvin, A Gomes, S Gomez Fernandez, F Goncalves Abrantes, M Goncerz, G Gong, J A Gooding, I V Gorelov, C Gotti, J P Grabowski, L A Granado Cardoso, E Graugés, E Graverini, L Grazette, G Graziani, A T Grecu, L M Greeven, N A Grieser, L Grillo, S Gromov, C Gu, M Guarise, M Guittiere, V Guliaeva, P A Günther, A-K Guseinov, E Gushchin, Y Guz, T Gys, T Hadavizadeh, C Hadjivasiliou, G Haefeli, C Haen, J Haimberger, M Hajheidari, T Halewood-Leagas, M M Halvorsen, P M Hamilton, J Hammerich, Q Han, X Han, S Hansmann-Menzemer, L Hao, N Harnew, T Harrison, M Hartmann, C Hasse, J He, K Heijhoff, F Hemmer, C Henderson, R D L Henderson, A M Hennequin, K Hennessy, L Henry, J Herd, P Herrero Gascon, J Heuel, A Hicheur, D Hill, S E Hollitt, J Horswill, R Hou, Y Hou, N Howarth, J Hu, J Hu, W Hu, X Hu, W Huang, W Hulsbergen, R J Hunter, M Hushchyn, D Hutchcroft, M Idzik, D Ilin, P Ilten, A Inglessi, A Iniukhin, A Ishteev, K Ivshin, R Jacobsson, H Jage, S J Jaimes Elles, S Jakobsen, E Jans, B K Jashal, A Jawahery, V Jevtic, E Jiang, X Jiang, Y Jiang, Y J Jiang, M John, D Johnson, C R Jones, T P Jones, S Joshi, B Jost, N Jurik, I Juszczak, D Kaminaris, S Kandybei, Y Kang, M Karacson, D Karpenkov, M Karpov, A M Kauniskangas, J W Kautz, F Keizer, D M Keller, M Kenzie, T Ketel, B Khanji, A Kharisova, S Kholodenko, G Khreich, T Kirn, V S Kirsebom, O Kitouni, S Klaver, N Kleijne, K Klimaszewski, M R Kmiec, S Koliiev, L Kolk, A Konoplyannikov, P Kopciewicz, P Koppenburg, M Korolev, I Kostiuk, O Kot, S Kotriakhova, A Kozachuk, P Kravchenko, L Kravchuk, M Kreps, S Kretzschmar, P Krokovny, W Krupa, W Krzemien, J Kubat, S Kubis, W Kucewicz, M Kucharczyk, V Kudryavtsev, E Kulikova, A Kupsc, B K Kutsenko, D Lacarrere, A Lai, A Lampis, D Lancierini, C Landesa Gomez, J J Lane, R Lane, C Langenbruch, J Langer, O Lantwin, T Latham, F Lazzari, C Lazzeroni, R Le Gac, S H Lee, R Lefèvre, A Leflat, S Legotin, M Lehuraux, O Leroy, T Lesiak, B Leverington, A Li, H Li, K Li, L Li, P Li, P-R Li, S Li, T Li, T Li, Y Li, Y Li, Z Li, Z Lian, X Liang, C Lin, T Lin, R Lindner, V Lisovskyi, R Litvinov, G Liu, H Liu, K Liu, Q Liu, S Liu, Y Liu, Y Liu, Y L Liu, A Lobo Salvia, A Loi, J Lomba Castro, T Long, J H Lopes, A Lopez Huertas, S López Soliño, G H Lovell, C Lucarelli, D Lucchesi, S Luchuk, M Lucio Martinez, V Lukashenko, Y Luo, A Lupato, E Luppi, K Lynch, X-R Lyu, G M Ma, R Ma, S Maccolini, F Machefert, F Maciuc, I Mackay, L R Madhan Mohan, M M Madurai, A Maevskiy, D Magdalinski, D Maisuzenko, M W Majewski, J J Malczewski, S Malde, B Malecki, L Malentacca, A Malinin, T Maltsev, G Manca, G Mancinelli, C Mancuso, R Manera Escalero, D Manuzzi, D Marangotto, J F Marchand, R Marchevski, U Marconi, S Mariani, C Marin Benito, J Marks, A M Marshall, P J Marshall, G Martelli, G Martellotti, L Martinazzoli, M Martinelli, D Martinez Santos, F Martinez Vidal, A Massafferri, M Materok, R Matev, A Mathad, V Matiunin, C Matteuzzi, K R Mattioli, A Mauri, E Maurice, J Mauricio, P Mayencourt, M Mazurek, M McCann, L Mcconnell, T H McGrath, N T McHugh, A McNab, R McNulty, B Meadows, G Meier, D Melnychuk, M Merk, A Merli, L Meyer Garcia, D Miao, H Miao, M Mikhasenko, D A Milanes, A Minotti, E Minucci, T Miralles, S E Mitchell, B Mitreska, D S Mitzel, A Modak, A Mödden, R A Mohammed, R D Moise, S Mokhnenko, T Mombächer, M Monk, I A Monroy, S Monteil, A Morcillo Gomez, G Morello, M J Morello, M P Morgenthaler, J Moron, A B Morris, A G Morris, R Mountain, H Mu, Z M Mu, E Muhammad, F Muheim, M Mulder, K Müller, F Muñoz-Rojas, R Murta, P Naik, T Nakada, R Nandakumar, T Nanut, I Nasteva, M Needham, N Neri, S Neubert, N Neufeld, P Neustroev, R Newcombe, J Nicolini, D Nicotra, E M Niel, N Nikitin, P Nogga, N S Nolte, C Normand, J Novoa Fernandez, G Nowak, C Nunez, H N Nur, A Oblakowska-Mucha, V Obraztsov, T Oeser, S Okamura, R Oldeman, F Oliva, M Olocco, C J G Onderwater, R H O'Neil, J M Otalora Goicochea, T Ovsiannikova, P Owen, A Oyanguren, O Ozcelik, K O Padeken, B Pagare, P R Pais, T Pajero, A Palano, M Palutan, G Panshin, L Paolucci, A Papanestis, M Pappagallo, L L Pappalardo, C Pappenheimer, C Parkes, B Passalacqua, G Passaleva, D Passaro, A Pastore, M Patel, J Patoc, C Patrignani, C J Pawley, A Pellegrino, M Pepe Altarelli, S Perazzini, D Pereima, A Pereiro Castro, P Perret, A Perro, K Petridis, A Petrolini, S Petrucci, H Pham, L Pica, M Piccini, B Pietrzyk, G Pietrzyk, D Pinci, F Pisani, M Pizzichemi, V Placinta, M Plo Casasus, F Polci, M Poli Lener, A Poluektov, N Polukhina, I Polyakov, E Polycarpo, S Ponce, D Popov, S Poslavskii, K Prasanth, C Prouve, V Pugatch, V Puill, G Punzi, H R Qi, W Qian, N Qin, S Qu, R Quagliani, R I Rabadan Trejo, B Rachwal, J H Rademacker, M Rama, M Ramírez García, M Ramos Pernas, M S Rangel, F Ratnikov, G Raven, M Rebollo De Miguel, F Redi, J Reich, F Reiss, Z Ren, P K Resmi, R Ribatti, G R Ricart, D Riccardi, S Ricciardi, K Richardson, M Richardson-Slipper, K Rinnert, P Robbe, G Robertson, E Rodrigues, E Rodriguez Fernandez, J A Rodriguez Lopez, E Rodriguez Rodriguez, A Rogovskiy, D L Rolf, A Rollings, P Roloff, V Romanovskiy, M Romero Lamas, A Romero Vidal, G Romolini, F Ronchetti, M Rotondo, S R Roy, M S Rudolph, T Ruf, M Ruiz Diaz, R A Ruiz Fernandez, J Ruiz Vidal, A Ryzhikov, J Ryzka, J J Saborido Silva, R Sadek, N Sagidova, N Sahoo, B Saitta, M Salomoni, C Sanchez Gras, I Sanderswood, R Santacesaria, C Santamarina Rios, M Santimaria, L Santoro, E Santovetti, A Saputi, D Saranin, G Sarpis, M Sarpis, A Sarti, C Satriano, A Satta, M Saur, D Savrina, H Sazak, L G Scantlebury Smead, A Scarabotto, S Schael, S Scherl, A M Schertz, M Schiller, H Schindler, M Schmelling, B Schmidt, S Schmitt, H Schmitz, O Schneider, A Schopper, N Schulte, S Schulte, M H Schune, R Schwemmer, G Schwering, B Sciascia, A Sciuccati, S Sellam, A Semennikov, M Senghi Soares, A Sergi, N Serra, L Sestini, A Seuthe, Y Shang, D M Shangase, M Shapkin, I Shchemerov, L Shchutska, T Shears, L Shekhtman, Z Shen, S Sheng, V Shevchenko, B Shi, E B Shields, Y Shimizu, E Shmanin, R Shorkin, J D Shupperd, R Silva Coutinho, G Simi, S Simone, N Skidmore, R Skuza, T Skwarnicki, M W Slater, J C Smallwood, E Smith, K Smith, M Smith, A Snoch, L Soares Lavra, M D Sokoloff, F J P Soler, A Solomin, A Solovev, I Solovyev, R Song, Y Song, Y Song, Y S Song, F L Souza De Almeida, B Souza De Paula, E Spadaro Norella, E Spedicato, J G Speer, E Spiridenkov, P Spradlin, V Sriskaran, F Stagni, M Stahl, S Stahl, S Stanislaus, E N Stein, O Steinkamp, O Stenyakin, H Stevens, D Strekalina, Y Su, F Suljik, J Sun, L Sun, Y Sun, P N Swallow, K Swientek, F Swystun, A Szabelski, T Szumlak, M Szymanski, Y Tan, S Taneja, M D Tat, A Terentev, F Terzuoli, F Teubert, E Thomas, D J D Thompson, H Tilquin, V Tisserand, S T'Jampens, M Tobin, L Tomassetti, G Tonani, X Tong, D Torres Machado, L Toscano, D Y Tou, C Trippl, G Tuci, N Tuning, L H Uecker, A Ukleja, D J Unverzagt, E Ursov, A Usachov, A Ustyuzhanin, U Uwer, V Vagnoni, A Valassi, G Valenti, N Valls Canudas, H Van Hecke, E van Herwijnen, C B Van Hulse, R Van Laak, M van Veghel, R Vazquez Gomez, P Vazquez Regueiro, C Vázquez Sierra, S Vecchi, J J Velthuis, M Veltri, A Venkateswaran, M Vesterinen, D Vieira, M Vieites Diaz, X Vilasis-Cardona, E Vilella Figueras, A Villa, P Vincent, F C Volle, D Vom Bruch, V Vorobyev, N Voropaev, K Vos, G Vouters, C Vrahas, J Walsh, E J Walton, G Wan, C Wang, G Wang, J Wang, J Wang, J Wang, J Wang, M Wang, N W Wang, R Wang, X Wang, X W Wang, Y Wang, Z Wang, Z Wang, Z Wang, J A Ward, N K Watson, D Websdale, Y Wei, B D C Westhenry, D J White, M Whitehead, A R Wiederhold, D Wiedner, G Wilkinson, M K Wilkinson, M Williams, M R J Williams, R Williams, F F Wilson, W Wislicki, M Witek, L Witola, C P Wong, G Wormser, S A Wotton, H Wu, J Wu, Y Wu, K Wyllie, S Xian, Z Xiang, Y Xie, A Xu, J Xu, L Xu, L Xu, M Xu, Z Xu, Z Xu, Z Xu, D Yang, S Yang, X Yang, Y Yang, Z Yang, Z Yang, V Yeroshenko, H Yeung, H Yin, C Y Yu, J Yu, X Yuan, E Zaffaroni, M Zavertyaev, M Zdybal, M Zeng, C Zhang, D Zhang, J Zhang, L Zhang, S Zhang, S Zhang, Y Zhang, Y Zhang, Y Z Zhang, Y Zhao, A Zharkova, A Zhelezov, X Z Zheng, Y Zheng, T Zhou, X Zhou, Y Zhou, V Zhovkovska, L Z Zhu, X Zhu, X Zhu, Z Zhu, V Zhukov, J Zhuo, Q Zou, D Zuliani, G Zunica
An amplitude analysis of the B^{0}→K^{*0}μ^{+}μ^{-} decay is presented using a dataset corresponding to an integrated luminosity of 4.7  fb^{-1} of pp collision data collected with the LHCb experiment. For the first time, the coefficients associated to short-distance physics effects, sensitive to processes beyond the standard model, are extracted directly from the data through a q^{2}-unbinned amplitude analysis, where q^{2} is the μ^{+}μ^{-} invariant mass squared...
March 29, 2024: Physical Review Letters
https://read.qxmd.com/read/38612641/microfluidic-isolation-of-neuronal-enriched-extracellular-vesicles-shows-distinct-and-common-neurological-proteins-in-long-covid-hiv-infection-and-alzheimer-s-disease
#20
JOURNAL ARTICLE
Lynn Pulliam, Bing Sun, Erin McCafferty, Steven A Soper, Malgorzata A Witek, Mengjia Hu, Judith M Ford, Sarah Song, Dimitrios Kapogiannis, Marshall J Glesby, Daniel Merenstein, Phyllis C Tien, Heather Freasier, Audrey French, Heather McKay, Monica M Diaz, Igho Ofotokun, Jordan E Lake, Joseph B Margolick, Eun-Young Kim, Steven R Levine, Margaret A Fischl, Wei Li, Jeremy Martinson, Norina Tang
Long COVID (LongC) is associated with a myriad of symptoms including cognitive impairment. We reported at the beginning of the COVID-19 pandemic that neuronal-enriched or L1CAM+ extracellular vesicles (nEVs) from people with LongC contained proteins associated with Alzheimer's disease (AD). Since that time, a subset of people with prior COVID infection continue to report neurological problems more than three months after infection. Blood markers to better characterize LongC are elusive. To further identify neuronal proteins associated with LongC, we maximized the number of nEVs isolated from plasma by developing a hybrid EV Microfluidic Affinity Purification (EV-MAP) technique...
March 29, 2024: International Journal of Molecular Sciences
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