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https://www.readbyqxmd.com/read/28698169/effectiveness-of-digital-medicines-to-improve-clinical-outcomes-in-patients-with-uncontrolled-hypertension-and-type-2-diabetes-prospective-open-label-cluster-randomized-pilot-clinical-trial
#1
Juan Frias, Naunihal Virdi, Praveen Raja, Yoona Kim, George Savage, Lars Osterberg
BACKGROUND: Hypertension and type 2 diabetes mellitus are major modifiable risk factors for cardiac, cerebrovascular, and kidney diseases. Reasons for poor disease control include nonadherence, lack of patient engagement, and therapeutic inertia. OBJECTIVE: The aim of this study was to assess the impact on clinic-measured blood pressure (BP) and glycated hemoglobin (HbA1c) using a digital medicine offering (DMO) that measures medication ingestion adherence, physical activity, and rest using digital medicines (medication taken with ingestible sensor), wearable sensor patches, and a mobile device app...
July 11, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28597911/digitizing-medicines-for-remote-capture-of-oral-medication-adherence-using-co-encapsulation
#2
Sara H Browne, Charles Peloquin, Frank Santillo, Richard Haubrich, Leticia Muttera, Kathleen Moser, George Savage, Constance Benson, Terrence Blaschke
High-resolution measurement of medication adherence is essential to personalized drug therapy . An FDA-cleared device, using an edible ingestion sensor (IS), external wearable patch and paired mobile device, can detect and record ingestion events. Oral medications must be combined with an IS to generate precise 'digitized-medication' ingestion records. We developed a GMP-protocol to repackage oral medications with the IS within certified CapsugelĀ® capsules, termed co-encapsulation (CoE). A randomized bioequivalence study of CoE-IS-Rifamate (Isoniazid/Rifampin 150/300mg) versus native-Rifamate was conducted in 12 patients with active Mycobacterium Tuberculosis (MTB) and demonstrated bioequivalence using the population method ratio test (95% CI)...
June 9, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28597138/advances-in-renal-genetic-diagnosis
#3
REVIEW
Carsten Bergmann
Most genetic disorders are clinically and genetically heterogeneous. Next-generation sequencing (NGS) has revolutionized the field and is providing rapidly growing insights into the pathomechanism of hereditary nephropathies. Current best-practice guidelines for most hereditary nephropathies include genetic diagnostics. The increasing number of genes that have to be considered in patients with hereditary nephropathies is often challenging when addressed by conventional techniques and largely benefits from NGS-based approaches that allow the parallel analysis of all disease genes in a single test at relatively low cost, e...
July 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28590335/technological-methods-to-measure-adherence-to-antiretroviral-therapy-and-preexposure-prophylaxis
#4
Lindsey E Garrison, Jessica E Haberer
PURPOSE OF REVIEW: The WHO's Consolidated Guidelines (2016) call for research on improved methods to proactively monitor adherence and identify those individuals who have the greatest needs for adherence support. This review aims to elucidate the latest technologies available to measure adherence to HIV antiretroviral therapy and preexposure prophylaxis against HIV infection and present their utility in various settings and populations. RECENT FINDINGS: Within the last few years, advances have been made in the features of existing technology to measure adherence (real-time electronic adherence measurements), additional approaches have been developed (digital medicine systems) and improved (short message service surveys), and point of care testing for pharmacokinetic measures are under development...
June 5, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28541648/expert-consensus-survey-on-medication-adherence-in-psychiatric-patients-and-use-of-a-digital-medicine-system
#5
Ainslie Hatch, John P Docherty, Daniel Carpenter, Ruth Ross, Peter J Weiden
BACKGROUND: There is an unmet need to objectively assess adherence problems that are a common cause of unexplained or unexpected suboptimal outcome. A digital medicine system (DMS) has been developed to address this need in patients with serious mental illness. OBJECTIVE: To conduct a quantitative expert consensus survey to (1) assess relative importance of causes of suboptimal outcomes, (2) examine modalities used to assess adherence, (3) provide guidance on when and how to use the DMS in clinical practice once available, and (4) suggest interventions for specific reasons for nonadherence...
May 23, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28412784/-three-dimensional-printing-and-oral-medicine
#6
M Hu
After 30 years of development, three-dimensional printing technology has made great progress, and the model and surgical guide have been clinically applied. The three-dimensional printing of titanium and other metal prosthesis and dental crown after adequate research will be applied clinically, and three-dimensional bioprinting and related biological materials need further study. Three-dimensional printing provides opportunities for the development of oral medicine, which will change the way of clinical work, teaching and research...
April 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28212968/-what-goes-around-comes-around-lessons-learned-from-economic-evaluations-of-personalized-medicine-applied-to-digital-medicine
#7
Kathryn A Phillips, Michael P Douglas, Julia R Trosman, Deborah A Marshall
BACKGROUND: The growth of "big data" and the emphasis on patient-centered health care have led to the increasing use of two key technologies: personalized medicine and digital medicine. For these technologies to move into mainstream health care and be reimbursed by insurers, it will be essential to have evidence that their benefits provide reasonable value relative to their costs. These technologies, however, have complex characteristics that present challenges to the assessment of their economic value...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28179216/navigating-ethics-in-the-digital-age-introducing-connected-and-open-research-ethics-core-a-tool-for-researchers-and-institutional-review-boards
#8
John Torous, Camille Nebeker
Research studies that leverage emerging technologies, such as passive sensing devices and mobile apps, have demonstrated encouraging potential with respect to favorably influencing the human condition. As a result, the nascent fields of mHealth and digital medicine have gained traction over the past decade as demonstrated in the United States by increased federal funding for research that cuts across a broad spectrum of health conditions. The existence of mHealth and digital medicine also introduced new ethical and regulatory challenges that both institutional review boards (IRBs) and researchers are struggling to navigate...
February 8, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28088344/design-control-considerations-for-biologic-device-combination-products
#9
REVIEW
Dave Anderson, Roger Liu, J Anand Subramony, Jon Cammack
Combination products are therapeutic and diagnostic medical products that combine drugs, devices, and/or biological products with one another. Historically, biologics development involved identifying efficacious doses administered to patients intravenously or perhaps by a syringe. Until fairly recently, there has been limited focus on developing an accompanying medical device, such as a prefilled syringe or auto-injector, to enable easy and more efficient delivery. For the last several years, and looking forward, where there may be little to distinguish biologics medicines with relatively similar efficacy profiles, the biotechnology market is beginning to differentiate products by patient-focused, biologic-device based combination products...
March 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/27824843/erratum-defining-digital-medicine
#10
Eric Elenko, Lindsay Underwood, Daphne Zohar
No abstract text is available yet for this article.
November 8, 2016: Nature Biotechnology
https://www.readbyqxmd.com/read/27785036/usability-of-a-novel-digital-medicine-system-in-adults-with-schizophrenia-treated-with-sensor-embedded-tablets-of-aripiprazole
#11
Timothy Peters-Strickland, Linda Pestreich, Ainslie Hatch, Shashank Rohatagi, Ross A Baker, John P Docherty, Lada Markovtsova, Praveen Raja, Peter J Weiden, David P Walling
OBJECTIVE: Digital medicine system (DMS) is a novel drug-device combination that objectively measures and reports medication ingestion. The DMS consists of medication embedded with an ingestible sensor (digital medicine), a wearable sensor, and software applications. This study evaluated usability of the DMS in adults with schizophrenia rated by both patients and their health care providers (HCPs) during 8-week treatment with prescribed doses of digital aripiprazole. METHODS: Six US sites enrolled outpatients into this Phase IIa, open-label study (NCT02219009)...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27591179/improving-hypertension-control-and-patient-engagement-using-digital-tools
#12
Richard V Milani, Carl J Lavie, Robert M Bober, Alexander R Milani, Hector O Ventura
Hypertension is present in 30% of the adult US population and is a major contributor to cardiovascular disease. The established office-based approach yields only 50% blood pressure control rates and low levels of patient engagement. Available home technology now provides accurate, reliable data that can be transmitted directly to the electronic medical record. We evaluated blood pressure control in 156 patients with uncontrolled hypertension enrolled into a home-based digital-medicine blood pressure program and compared them with 400 patients (matched to age, sex, body mass index, and blood pressure) in a usual-care group after 90 days...
January 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/27560260/digital-medicine-empowering-both-patients-and-clinicians
#13
COMMENT
Eric Topol
No abstract text is available yet for this article.
August 20, 2016: Lancet
https://www.readbyqxmd.com/read/27547580/a-framework-for-smartphone-enabled-patient-generated-health-data-analysis
#14
Shreya S Gollamudi, Eric J Topol, Nathan E Wineinger
BACKGROUND: Digital medicine and smartphone-enabled health technologies provide a novel source of human health and human biology data. However, in part due to its intricacies, few methods have been established to analyze and interpret data in this domain. We previously conducted a six-month interventional trial examining the efficacy of a comprehensive smartphone-based health monitoring program for individuals with chronic disease. This included 38 individuals with hypertension who recorded 6,290 blood pressure readings over the trial...
2016: PeerJ
https://www.readbyqxmd.com/read/27524308/digital-medicine-and-biomedical-informatics-what-s-in-a-name
#15
EDITORIAL
Edward H Shortliffe
No abstract text is available yet for this article.
October 17, 2016: Methods of Information in Medicine
https://www.readbyqxmd.com/read/27524112/discussion-of-the-new-role-of-biomedical-informatics-in-the-age-of-digital-medicine
#16
Najeeb Al-Shorbaji, Riccardo Bellazzi, Fernan Gonzalez Bernaldo de Quiros, Sabine Koch, Casimir A Kulikowski, Nigel H Lovell, Victor Maojo, Hyeoun-Ae Park, Ferran Sanz, Indra N Sarkar, Hiroshi Tanaka
This article is part of a For-Discussion-Section of Methods of Information in Medicine about the paper "The New Role of Biomedical Informatics in the Age of Digital Medicine" written by Fernando J. Martin-Sanchez and Guillermo H. Lopez-Campos [1]. It is introduced by an editorial. This article contains the combined commentaries invited to independently comment on the paper of Martin-Sanchez and Lopez-Campos. In subsequent issues the discussion can continue through letters to the editor.
October 17, 2016: Methods of Information in Medicine
https://www.readbyqxmd.com/read/27523651/the-new-role-of-biomedical-informatics-in-the-age-of-digital-medicine
#17
Fernando J Martin-Sanchez, Guillermo H Lopez-Campos
OBJECTIVES: To reflect on the recent rise of Digital Medicine, as well as to analyse main research opportunities in this area. Through the use of several examples, this article aims to highlight the new role that Biomedical Informatics (BMI) can play to facilitate progress in research fields such as participatory and precision medicine. This paper also examines the potential impact and associated risks for BMI due to the development of digital medicine and other recent trends. Lastly, possible strategies to place BMI in a better position to face these challenges are suggested...
October 17, 2016: Methods of Information in Medicine
https://www.readbyqxmd.com/read/27491465/digital-medicine-o-brave-new-world
#18
EDITORIAL
Joseph S Alpert
No abstract text is available yet for this article.
March 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/27487251/optimization-of-a-digital-medicine-system-in-psychiatry
#19
Shashank Rohatagi, Deborah Profit, Ainslie Hatch, Cathy Zhao, John P Docherty, Timothy S Peters-Strickland
BACKGROUND: Nonadherence to medication compromises the effectiveness of psychiatric treatments in patients with serious mental illness (SMI). A newly developed digital medicine system (DMS) offers an opportunity to objectively assess and report patient medication adherence. DMS includes a wearable sensor that receives a data signal from a medication tablet with an embedded ingestible sensor after ingestion of the medication and transmits that data to the patient's mobile device to display health care information for the patient and treatment team...
September 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27429311/annals-for-hospitalists-inpatient-notes-hospitalists-and-digital-medicine-overcoming-the-productivity-paradox
#20
Robert M Wachter
No abstract text is available yet for this article.
July 19, 2016: Annals of Internal Medicine
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