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https://www.readbyqxmd.com/read/27903675/a-pam50-based-chemo-endocrine-score-for-hormone-receptor-positive-breast-cancer-with-an-intermediate-risk-of-relapse
#1
Aleix Prat, Ana Lluch, Arran K Turnbull, Anita K Dunbier, Lourdes Calvo, Joan Albanell, Juan de la Haba-Rodríguez, Angels Arcusa, Ignacio Chacón, Pedro Sánchez-Rovira, Arrate Plazaola, Montse Muñoz, Laia Paré, Joel S Parker, Nuria Ribelles, Begona Jimenez, Abdul Aziz Bin Aiderus, Rosalía Caballero, Barbara Adamo, Mitch Dowsett, Eva M Carrasco, Miguel Martín, J Michael Dixon, Charles M Perou, Emilio Alba
PURPOSE: Hormone receptor-positive (HR+) breast cancer is clinically and biologically heterogeneous and subgroups with different prognostic and treatment sensitivities need to be identified. EXPERIMENTAL DESIGN: Research-based PAM50 subtyping and expression of additional genes was performed on 63 patients with HR+/HER2- disease randomized to neoadjuvant multi-agent chemotherapy versus endocrine therapy in a phase II trial. The biology associated with treatment response was used to derive a PAM50-based Chemo-Endocrine Score (CES)...
November 30, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27902958/fructosylation-induced-structural-changes-in-mammalian-dna-examined-by-biophysical-techniques
#2
Asif Zaman, Zarina Arif, Khursheed Alam
Glycosylation of DNA, proteins, lipids, etc. by reducing sugars, can lead to the formation of advanced glycation end products (AGEs). These products may accumulate and involve in the pathogenesis of a number of diseases, contributing to tissue injury via several mechanisms. In this study, fructosylation of calf thymus dsDNA was carried out with varying concentrations of fructose. The neo-structure of fructosylated-DNA was studied by various biophysical techniques and morphological characterization. Fructosylated-DNA showed hyperchromicity, increase in fluorescence intensity and decrease in melting temperature...
November 20, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27899395/functional-definition-of-progenitors-versus-mature-endothelial-cells-reveals-key-soxf-dependent-differentiation-process
#3
Jatin Patel, Elke J Seppanen, Mathieu P Rodero, Ho Yi Wong, Prudence Donovan, Zoltan Neufeld, Nicholas M Fisk, Mathias François, Kiarash Khosrotehrani
BACKGROUND: -During adult life, blood vessel formation is thought to occur via angiogenic processes involving branching from existing vessels. An alternate proposal suggests that neo-vessels form from endothelial progenitors able to assemble the intimal layers. We here aimed to define vessel-resident endothelial progenitors in vivo in a variety of tissues in physiological and pathological situations such as normal aorta, lungs, as well as wound healing, tumors and placenta. METHODS: -Based on protein expression levels of common endothelial markers using flow cytometry, three sub-populations of endothelial cells could be identified among VE-Cadherin+ and CD45- cells...
November 29, 2016: Circulation
https://www.readbyqxmd.com/read/27898799/effects-of-dolomitic-limestone-application-on-zinc-speciation-in-boreal-forest-smelter-contaminated-soils
#4
Jordan G Hamilton, Richard E Farrell, Ning Chen, Joel Reid, Renfei Feng, Derek Peak
Anthropogenic activities at the HudBay Minerals, Inc., Flin Flon (Manitoba, Canada) mining and processing facility have severely affected the surrounding boreal forest ecosystem. Soil contamination occurred via a combination of metal and sulfuric acid deposition and has resulted in forest dieback and ineffective natural recovery. A community-led effort to revegetate areas of the landscape through the application of a dolomitic limestone has been met with varied success. Zinc (Zn) speciation has shown to be closely linked to the presence or absence of an invasive metal-tolerant grass species, with soils being broadly classed into two revegetation response groups...
November 2016: Journal of Environmental Quality
https://www.readbyqxmd.com/read/27897175/accelerated-pseudogenization-on-the-neo-x-chromosome-in-drosophila-miranda
#5
Masafumi Nozawa, Kanako Onizuka, Mai Fujimi, Kazuho Ikeo, Takashi Gojobori
Y chromosomes often degenerate via the accumulation of pseudogenes and transposable elements. By contrast, little is known about X-chromosome degeneration. Here we compare the pseudogenization process between genes on the neo-sex chromosomes in Drosophila miranda and their autosomal orthologues in closely related species. The pseudogenization rate on the neo-X is much lower than the rate on the neo-Y, but appears to be higher than the rate on the orthologous autosome in D. pseudoobscura. Genes under less functional constraint and/or genes with male-biased expression tend to become pseudogenes on the neo-X, indicating the accumulation of slightly deleterious mutations and the feminization of the neo-X...
November 29, 2016: Nature Communications
https://www.readbyqxmd.com/read/27897162/batf3-selectively-determines-acquisition-of-cd8-dendritic-cell-phenotype-and-function
#6
Janin Chandra, Paula T Y Kuo, Anne M Hahn, Gabrielle T Belz, Ian H Frazer
Batf3 is a transcription factor that impacts the development of CD103(+) tissue-resident dendritic cells (DCs). However, whether Batf3 is absolutely required for the development of CD8(+) DCs remains controversial. Id2 is required for CD8(+) DC development. Here we show that bone marrow chimeric mice with a deletion of Id2 in the CD11c compartment lose the ability to reject a skin graft expressing a non-self protein antigen or mount a delayed hypersensitivity response. In contrast, Batf3((-/-)) mice remained competent for skin graft rejection and delayed hypersensitivity, and retained a CD8(+) DC population with markers characteristic of the CD11b(+) DC lineage, including CD11b, CD4 and CD172α, as well as the key regulator transcription factor IRF4, but lacked IRF8 expression...
November 29, 2016: Immunology and Cell Biology
https://www.readbyqxmd.com/read/27896952/muscle-strength-in-breast-cancer-patients-receiving-different-treatment-regimes
#7
Oliver Klassen, Martina E Schmidt, Cornelia M Ulrich, Andreas Schneeweiss, Karin Potthoff, Karen Steindorf, Joachim Wiskemann
BACKGROUND: Muscle dysfunction and sarcopenia have been associated with poor performance status, an increased mortality risk, and greater side effects in oncologic patients. However, little is known about how performance is affected by cancer therapy. We investigated muscle strength in breast cancer patients in different adjuvant treatment settings and also compared it with data from healthy individuals. METHODS: Breast cancer patients (N = 255) from two randomized controlled exercise trials, staged 0-III and aged 54...
November 28, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27895642/functional-and-structural-characterization-of-a-novel-hla-drb1-04-01-restricted-%C3%AE-enolase-t-cell-epitope-in-rheumatoid-arthritis
#8
Christina Gerstner, Anatoly Dubnovitsky, Charlotta Sandin, Genadiy Kozhukh, Hannes Uchtenhagen, Eddie A James, Johan Rönnelid, Anders Jimmy Ytterberg, Jennifer Pieper, Evan Reed, Carolina Tandre, Mary Rieck, Roman A Zubarev, Lars Rönnblom, Tatyana Sandalova, Jane H Buckner, Adnane Achour, Vivianne Malmström
Antibodies to citrullinated proteins, common in rheumatoid arthritis (RA) patients, are strongly associated to a specific set of HLA-DR alleles including HLA-DRB1*04:01, *04:04, and *01:01. Here, we first demonstrate that autoantibody levels toward the dominant citrullinated B cell epitope from α-enolase are significantly elevated in HLA-DRB1*04:01-positive RA patients. Furthermore, we identified α-enolase-derived T cell epitopes and demonstrated that native and citrullinated versions of several peptides bind with different affinities to HLA-DRB1*04:01, *04:04, and *01:01...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27894458/personality-and-global-cognitive-decline-in-japanese-community-dwelling-elderly-people-a-10-year-longitudinal-study
#9
Yukiko Nishita, Chikako Tange, Makiko Tomida, Rei Otsuka, Fujiko Ando, Hiroshi Shimokata
OBJECTIVES: To examine the longitudinal associations between the big five personality and changes in global cognitive function among community-dwelling elderly people involved in the National Institute for Longevity Sciences - Longitudinal Study of Aging. METHODS: The participants were 594 individuals (age range 60-81years) and followed for 10years and tested six times. Personality was assessed by the Japanese version of NEO five factor inventory at baseline. Cognitive function was assessed by the Japanese version of Mini Mental State Examination (MMSE) at all visits...
December 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27894377/effect-of-a-spiritual-care-training-program-for-staff-on-patient-outcomes
#10
Grace Meijuan Yang, Yung Ying Tan, Yin Bun Cheung, Weng Kit Lye, Sock Hui Amy Lim, Wan Ru Ng, Christina Puchalski, Patricia Soek Hui Neo
OBJECTIVE: Physicians and nurses do not assess spirituality routinely, even though spiritual care is a vital part of palliative care for patients with an advanced serious illness. The aim of our study was to determine whether a training program for healthcare professionals on spirituality and the taking of a spiritual history would result in improved patient quality of life (QoL) and spiritual well-being. METHOD: This was a cluster-controlled trial of a spiritual care training program for palliative care doctors and nurses...
November 29, 2016: Palliative & Supportive Care
https://www.readbyqxmd.com/read/27893634/comparison-of-different-acellular-dermal-matrix-adm-in-breast-reconstruction-the-50-50-study
#11
Troy A Pittman, Kenneth L Fan, Andrew Knapp, Shelby Frantz, Scott L Spear
BACKGROUND: Acellular Dermal Matrix (ADM) has enjoyed extensive use in primary and secondary alloplastic breast aesthetic and reconstructive surgery. The objective of this study is to examine clinical outcomes between available ADM: DermACELL(LifeNet Health, Virginia Beach, VA) and AlloDerm RTU (LifeCell, Branchburg, New Jersey). METHODS: A retrospective chart review was performed on 58 consecutive patients (100 breasts) reconstructed with either DermACELL(n=30 patients; 50 breasts) or AlloDerm RTU (n=28 patients; 50 breasts)...
November 21, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27893280/establishment-of-a-human-breast-cancer-model-by-fusion-pcr-for-in-vivo-and-in-vitro-fluorescence-imaging-of-human-breast-cancer
#12
Can Huang, Wenjun Lan, Feifei Wang, Chun Zhang, Xiaomei Liu, Qin Chen
This study aimed to construct a breast cancer model that could continuously express the genes of luciferase and green fluorescent protein. The genes luciferase, EGFP, and Neo were obtained by fusion polymerase chain reaction (PCR) and inserted into pAAV-MCS. The pAAV-Luciferase-EGFP-Neo vector was transfected into MDA-MB-231 cells. After antibiotic resistance gene screening and limiting dilution assay, we constructed a monoclonal stable cell line that expresses the fusion protein Luciferase-EGFP. In comparison with the polyclonal stable cell line, the monoclonal cell line had good genetic stability and was not different from the parental cell line MDA-MB-231...
November 28, 2016: DNA and Cell Biology
https://www.readbyqxmd.com/read/27893187/-to-twist-or-not-to-twist-figure-of-eight-and-planar-structures-of-octaphyrins
#13
REVIEW
Neelam Shivran, Santosh C Gadekar, Venkataramanarao G Anand
Amongst the various porphyrinoids, octaphyrin has attracted significant attention owing to its diverse syntheses, conformations, and metal-ligation properties. Octaphyrin is a higher homologue of porphyrin and is formed by linking together heterocycles such as pyrrole, furan, thiophene, and selenophene through α-α or α-meso carbon bonds. The planar conformation is mainly achieved through inversion of the heterocyclic units from the center of macrocycle; avoiding meso-bridges; introducing a para-quinodimethane bridge; employing a neo-confusion approach; protonation; and by generating dianionic species...
November 28, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27892493/autologous-temporomandibular-joint-reconstruction-independent-of-exogenous-additives-a-proof-of-concept-study-for-guided-self-generation
#14
Jiao Wei, Tanja Herrler, Dong Han, Kai Liu, Rulin Huang, Markus Guba, Chuanchang Dai, Qingfeng Li
Joint defects are complex and difficult to reconstruct. By exploiting the body's own regenerative capacity, we aimed to individually generate anatomically precise neo-tissue constructs for autologous joint reconstruction without using any exogenous additives. In a goat model, CT scans of the mandibular condyle including articular surface and a large portion of the ascending ramus were processed using computer-aided design and manufacturing. A corresponding hydroxylapatite negative mold was printed in 3D and temporarily embedded into the transition zone of costal periosteum and perichondrium...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27891043/time-perspectives-predict-mood-states-and-satisfaction-with-life-over-and-above-personality
#15
Maciej Stolarski, Gerald Matthews
The present study aimed to test the incremental validity of Time Perspective (TP) scales in predicting satisfaction with life and mood, over and above the Big Five personality traits. It also investigated whether the new TP construct of Future Negative perspective contributed to prediction of these outcomes. Participants (N = 265) completed four measures: Satisfaction With Life Scale (SWLS), UWIST Mood Adjective Checklist (UMACL), a modified Zimbardo Time Perspective Inventory (ZTPI), and NEO-Five Factor Inventory (NEO-FFI)...
2016: Current Psychology
https://www.readbyqxmd.com/read/27890806/the-endocrine-disrupting-potential-of-monosodium-glutamate-msg-on-secretion-of-the-glucagon-like-peptide-1-glp-1-gut-hormone-and-glp-1-receptor-interaction
#16
Maeve Shannon, Brian Green, Gary Willars, Jodie Wilson, Natalie Matthews, Joanna Lamb, Anna Gillespie, Lisa Connolly
Monosodium glutamate (MSG) is a suspected obesogen with epidemiological evidence positively correlating consumption to increased body mass index and higher prevalence of metabolic syndrome. ELISA and high content analysis (HCA) were employed to examine the disruptive effects of MSG on the secretion of enteroendocrine hormone glucagon-like peptide-1 (GLP-1) and GLP-1 receptor (GLP-1R), respectively. Following 3h MSG exposure of the enteroendocrine pGIP/neo: STC-1 cell line model (500μg/ml) significantly increased GLP-1 secretion (1...
November 24, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27890017/extremely-low-nucleotide-diversity-in-the-x-linked-region-of-papaya-caused-by-a-strong-selective-sweep
#17
Robert VanBuren, Ching Man Wai, Jisen Zhang, Jennifer Han, Jie Arro, Zhicong Lin, Zhenyang Liao, Qingyi Yu, Ming-Li Wang, Francis Zee, Richard C Moore, Deborah Charlesworth, Ray Ming
BACKGROUND: The papaya Y-linked region showed clear population structure, resulting in the detection of the ancestral male population that domesticated hermaphrodite papayas were selected from. The same populations were used to study nucleotide diversity and population structure in the X-linked region. RESULTS: Diversity is very low for all genes in the X-linked region in the wild dioecious population, with nucleotide diversity π syn = 0.00017, tenfold lower than the autosomal region (π syn = 0...
November 28, 2016: Genome Biology
https://www.readbyqxmd.com/read/27888771/increased-anxiety-like-behaviors-but-blunted-cortisol-stress-response-after-neonatal-hippocampal-lesions-in-monkeys
#18
Jessica Raper, Mark Wilson, Mar Sanchez, Christa Payne, Jocelyne Bachevalier
The hippocampus is most notably known for its role in cognition and spatial memory; however it also plays an essential role in emotional behaviors and neuroendocrine responses. The current study investigated the long-term effects of neonatal hippocampal lesions (Neo-Hibo) on emotional and hypothalamic-pituitary-adrenal (HPA) axis functioning. During infancy, unlike controls, Neo-Hibo monkeys exhibited enhanced expression of emotional behaviors (e.g. freezing, anxiety-like, and self-directed behaviors) when exposed to a human intruder (HI task)...
November 18, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27885905/facilitating-terminal-discharge-fulfilling-the-hospitalised-patient-s-wish-for-home-death-in-the-final-hours
#19
Yung Ying Tan, Zhi Zhen Xu, Grace Sy Pang, Limin Qu, Yi Xu, Ai Min Zhang, Patricia Sh Neo
BACKGROUND: Terminal discharge (TD) is the rapid discharge of a hospitalised patient when death is imminent. Its time-limited nature makes it challenging, particularly for ward nurses. AIM: To report the development of a structured TD framework, and determine if the framework can expedite TD processes and improve nurses' experience in conducting TDs. METHODS: A 3-phase audit was carried out in a Singapore hospital. The baseline and post intervention audits evaluated the time taken for TD, incidence of prescription errors, continuity of care, and timeliness of equipment arrangement...
November 2, 2016: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/27885570/neo-darwinists-and-neo-aristotelians-how-to-talk-about-natural-purpose
#20
Peter Woodford
This paper examines the points of disagreement between Neo-Darwinian and recent Neo-Aristotelian discussions of the status of purposive language in biology. I discuss recent Neo-Darwinian "evolutionary" treatments and distinguish three ways to deal with the philosophical status of teleological language of purpose: teleological error theory, methodological teleology, and Darwinian teleological realism. I then show how "non-evolutionary" Neo-Aristotelian approaches in the work of Michael Thompson and Philippa Foot differ from these by offering a view of purposiveness grounded in life-cycle patterns, rather than in long-term evolutionary processes or natural selection...
December 2016: History and Philosophy of the Life Sciences
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