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https://www.readbyqxmd.com/read/29051571/a-new-cellular-type-in-invertebrates-first-evidence-of-telocytes-in-leech-hirudo-medicinalis
#1
Laura Pulze, Nicolò Baranzini, Rossana Girardello, Annalisa Grimaldi, Lidia Ibba-Manneschi, Enzo Ottaviani, Marcella Reguzzoni, Gianluca Tettamanti, Magda de Eguileor
Telocytes, a peculiar cell type, were recently found in vertebrates. Hence this cell system has been reported as ubiquitous in the bodies of mammals and interpreted as an important player in innate immunity and tissue regeneration, it is reasonable to look for it also in invertebrates, that rely their integrity solely by innate immunity. Here we describe, at morphological and functional level, invertebrate telocytes from the body of leech Hirudo medicinalis (Annelida), suggesting how these cells, forming a resident stromal 3D network, can influence or participate in different events...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051567/mesenchymal-stem-stromal-cells-enhance-engraftment-vasculogenic-and-pro-angiogenic-activities-of-endothelial-colony-forming-cells-in-immunocompetent-hosts
#2
Abbas Shafiee, Jatin Patel, James S Lee, Dietmar W Hutmacher, Nicholas M Fisk, Kiarash Khosrotehrani
The clinical use of endothelial colony forming cells (ECFC) is hampered by their restricted engraftment. We aimed to assess engraftment, vasculogenic and pro-angiogenic activities of ECFC in immunocompetent (C57BL/6: WT) or immunodeficient (rag1 (-/-) C57BL/6: Rag1) mice. In addition, the impact of host immune system was investigated where ECFC were co-implanted with mesenchymal stem/stromal cells (MSC) from adult bone marrow (AdBM-MSC), fetal bone marrow (fBM-MSC), fetal placental (fPL-MSC), or maternal placental (MPL-MSC)...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29050626/a-comparison-of-the-acurate-neo-and-sapien-3-valves-making-progress
#3
EDITORIAL
Kreton Mavromatis
No abstract text is available yet for this article.
October 23, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29050625/multicenter-comparison-of-novel-self-expanding-versus-balloon-expandable-transcatheter-heart%C3%A2-valves
#4
Oliver Husser, Won-Keun Kim, Costanza Pellegrini, Andreas Holzamer, Thomas Walther, Patrick N Mayr, Michael Joner, Albert M Kasel, Teresa Trenkwalder, Jonathan Michel, Tobias Rheude, Adnan Kastrati, Heribert Schunkert, Christof Burgdorf, Michael Hilker, Helge Möllmann, Christian Hengstenberg
OBJECTIVES: This study sought to compare 2 next-generation transcatheter heart valves (THV), the self-expanding ACURATE neo (NEO) and the balloon-expandable SAPIEN 3 (S3), in terms of device failure and early safety at 30 days. BACKGROUND: Deployment of these THV showed promising initial clinical results. However, no comparative data are available. METHODS: Of 1,121 treated patients at 3 centers, a 1-to-2 nearest neighbor matching was performed to identify 2 patients treated with S3 (n = 622) for each patient treated with NEO (n = 311)...
October 23, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29047223/regeneration-of-osteochondral-defects-in-vivo-by-a-cell-free-cylindrical-poly-lactide-co-glycolide-scaffold-with-a-radially-oriented-microstructure
#5
Yuankun Dai, Tao Shen, Lie Ma, Dongan Wang, Changyou Gao
A scaffold with an oriented porous architecture to facilitate cell infiltration and bioactive interflow between neo-host tissues is of great importance for in situ inductive osteochondral regeneration. In this study, a poly(lactide-co-glycolide) (PLGA) scaffold with oriented pores in its radial direction (O-PLGA) was fabricated via unidirectional cooling of the PLGA solution in the radial direction, following with lyophilization. Micro-CT evaluation and SEM observation confirmed the radially oriented microtubular pores in the scaffold...
October 19, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29042587/mir-302b-suppresses-osteosarcoma-cell-migration-and-invasion-by-targeting-runx2
#6
Yuanlong Xie, Wenchao Sun, Zhouming Deng, Xiaobin Zhu, Chao Hu, Lin Cai
Osteosarcoma patients with lung metastasis and local invasion remain challenging to treat despite the significant contribution of the combination of surgery and neo-adjuvant chemotherapy. Our previous microarray study demonstrated that miR-302b had significantly lower expression in osteosarcoma cell lines than in osteoblast cell lines. In the present study, we further elucidated the role of miR-302b in regulating the migration and invasiveness of osteosarcoma. MiR-302b expression was markedly down-regulated in osteosarcoma cell lines and clinical tumour tissues...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29041522/oam-interferometry-the-detection-of-the-rotational-doppler-shift
#7
Richard Neo, Sergio Leon-Saval, Joss Bland-Hawthorn, Gabriel Molina-Terriza
In this paper, we propose a new type of rotational Doppler shift measurement based on the OAM of light which is capable of measuring the rotation of a point source in the plane orthogonal to the observer line of sight. By analysing the correlations between OAM states of light emitted by rotating sources, the rotational Doppler shift, and hence the rate of rotation, can be measured. We demonstrate that an OAM interferometer capable of extracting the rotational Doppler shift from OAM correlations can be constructed from a standard OAM modesorter combined with a phase filter...
September 4, 2017: Optics Express
https://www.readbyqxmd.com/read/29040490/proceedings-from-an-international-conference-on-ablation-therapy-for-barrett-s-mucosa-brittany-france-31-august-2-september-1997
#8
C G Bremner, T R Demeester
The increasing incidence of adenocarcinoma of the lower esophagus and cardia arising in Barrett's metaplastic epithelium continues to be of great concern because medical and surgical efforts to reverse the process have been disappointing. A potential answer to the problem is removal of the metaplastic epithelium. Modern technology has introduced physical and chemical modalities which facilitate ablation of the neo-epithelium endoscopically. These techniques have been used in several centers, and preliminary results are encouraging...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29040277/personality-and-achievement-along-medical-training-evidence-from-a-cross-lagged-analysis
#9
Isabel Lourinho, Maria Amélia Ferreira, Milton Severo
INTRODUCTION: Evidence on personality traits change implies it should be studied as an outcome and not only as an explanatory effect. Therefore, we aimed to assess how personality and academic achievement sway each other. Three cohorts of medical students (n = 181) comprised of school leavers and graduates, completed NEO-FFI when admitted (baseline) and later on medical training (follow-up). Previous achievement was measured as mean scores on national school examinations, and academic achievement as medical course average...
2017: PloS One
https://www.readbyqxmd.com/read/29038257/the-novel-transcriptional-regulator-lmbu-promotes-lincomycin-biosynthesis-through-regulating-expression-of-its-target-genes-in-streptomyces-lincolnensis
#10
Bingbing Hou, Yanwei Lin, Haizhen Wu, Meijin Guo, Hrvoje Petkovic, Liyuan Tao, Xiaoyu Zhu, Jiang Ye, Huizhan Zhang
Lincomycin A is a clinically important antimicrobial agent produced by Streptomyces lincolnensis In this study, a new regulator designated LmbU (Genbank accession no. ABX00623.1) was identified and characterized to regulate lincomycin biosynthesis in a S. lincolnensis wild-type strain NRRL 2936. Both inactivation and overexpression of lmbU result in significant influences on lincomycin production. Transcriptional analysis and in vivo neomycin resistance (neo(r) ) reporter assays demonstrated that LmbU activates expression of the lmbA, lmbC, lmbJ and lmbW genes, and represses expression of the lmbK and lmbU genes...
October 16, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/29035686/the-human-odontoblast-cell-layer-and-dental-pulp-proteomes-and-n-terminomes
#11
S R Abbey, U Eckhard, N Solis, G Marino, I Matthew, C M Overall
The proteome and N-terminome of the human odontoblast cell layer were identified for the first time by shotgun proteomic and terminal amine isotopic labeling of substrates (TAILS) N-terminomic analyses, respectively, and compared with that of human dental pulp stroma from 26 third molar teeth. After reverse-phase liquid chromatography-tandem mass spectrometry, >170,000 spectra from the shotgun and TAILS analyses were matched by 4 search engines to 4,888 and 12,063 peptides in the odontoblast cell layer and pulp stroma, respectively...
October 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29034351/bridging-patients-with-hepatocellular-cancer-waiting-for-liver-transplant-all-the-patients-are-the-same
#12
REVIEW
Martina Coletta, Daniele Nicolini, Andrea Benedetti Cacciaguerra, Susanna Mazzocato, Roberta Rossi, Marco Vivarelli
Liver transplant (LT) is considered the best curative treatment for patients with cirrhosis and hepatocellular carcinoma (HCC) within Milan criteria. The possibility to perform LT in HCC patients is limited by the liver grafts supply; indeed, the shortage of donors often leads to a long time on waiting list and then to dropout because of tumor progression. Bridging therapies are neo-adjuvant treatments given to patients on LT waitlist, with the aim to prevent tumor progression and to reduce dropout rate. Many bridging modalities have been proposed...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29034161/going-green-ex-post-valuation-of-a-multipurpose-water-infrastructure-in-northern-italy
#13
Arnaud Reynaud, Denis Lanzanova, Camino Liquete, Bruna Grizzetti
A contingent valuation approach is used to estimate how households value different multipurpose infrastructures (conventional or green) for managing flood risk and water pollution. As a case study we consider the Gorla Maggiore water park located in the Lombardy Region, in Northern Italy. The park is a neo-ecosystem including an infrastructure to treat waste water and store excess rain water, built in 2011 on the shore of the Olona River in an area previously used for poplar plantation. This park is the first one of this type built in Italy...
October 2017: Ecosystem Services
https://www.readbyqxmd.com/read/29033899/environmental-factors-contribute-to-%C3%AE-cell-endoplasmic-reticulum-stress-and-neo-antigen-formation-in-type-1-diabetes
#14
Meghan L Marré, Jon D Piganelli
Type 1 diabetes (T1D) is an autoimmune disease in which immune-mediated targeting and destruction of insulin-producing pancreatic islet β cells leads to chronic hyperglycemia. There are many β cell proteins that are targeted by autoreactive T cells in their native state. However, recent studies have demonstrated that many β cell proteins are recognized as neo-antigens following posttranslational modification (PTM). Although modified neo-antigens are well-established targets of pathology in other autoimmune diseases, the effects of neo-antigens in T1D progression and the mechanisms by which they are generated are not well understood...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29032372/parenchymal-sparing-surgery-for-the-surgical-treatment-of-multiple-colorectal-liver-metastases-is-a-safer-approach-than-major-hepatectomy-not-impairing-patients-prognosis-a-bi-institutional-propensity-score-matched-analysis
#15
Matteo Donadon, Matteo Cescon, Alessandro Cucchetti, Matteo Cimino, Guido Costa, Benedetta Pesi, Giorgio Ercolani, Antonio Daniele Pinna, Guido Torzilli
BACKGROUND: The performance of parenchymal-sparing hepatectomy (PSH) versus major hepatectomy (MH) in patients with multiple colorectal liver metastases (CLM) is a matter that is yet debated. We investigated the outcome of patients with multiple CLM undergoing PSH instead of MH. METHODS: Databases at 2 institutions were reviewed. A propensity score-matched analysis was applied. Among 554 patients, 110 undergoing PSH and 110 undergoing MH were matched. They were similar in baseline characteristics, comorbidity, and tumor features...
October 14, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29031320/burnout-and-its-relationship-with-personality-factors-in-oncology-nurses
#16
Emilia I De la Fuente-Solana, José L Gómez-Urquiza, Gustavo R Cañadas, Luis Albendín-García, Elena Ortega-Campos, Guillermo A Cañadas-De la Fuente
PURPOSE: To assess burnout levels in oncology nurses, to evaluate at what stage of burnout suffering they are and to analyze the relationship between burnout with personality factors. METHOD: A quantitative, observational, cross-sectional multicenter study was done. Oncology nurses (n = 101) from the Andalusian Health Service (Andalusia, Spain) were included. The main variables were personality factors, assessed with the NEO-FFI questionnaire, anxiety and depression, assessed with the Educational-Clinical Questionnaire: Anxiety and Depression, and burnout, evaluated with the Maslach Burnout Inventory...
October 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29031114/neo-clerodane-diterpenoids-from-the-whole-plants-of-scutellaria-formosana
#17
Xin Chen, Wenhao Chen, Guangying Chen, Changri Han, Johnny J He, Xueming Zhou, Zhangxin Yu, Chunyan Dai, Xiaoping Song
Scuteformoids A-J, ten previously undescribed neo-clerodane diterpenoids along with one known analogue, were isolated from petroleum ether soluable fraction of the whole plants of Scutellaria formosana. The differences among these compounds are the substituents and stereochemistry at C-13. Their structures were elucidated by 1D and 2D NMR experiments, and the absolute configurations of Scuteformoids A, C, E, F, and I were further confirmed by single-crystal X-ray diffraction. Scuteformoids A, C, D, F, H, and I were evaluated for their inhibitory effects against HIV lytic replication and cytotoxic activities...
October 11, 2017: Phytochemistry
https://www.readbyqxmd.com/read/29029986/radiofrequency-ablation-for-colorectal-cancer-liver-metastases-initially-greater-than-25%C3%A2-mm-but-downsized-by-neo-adjuvant-chemotherapy-is-associated-with-increased-rate-of-local-tumor-progression
#18
Léonor Benhaim, Mostafa El Hajjam, Robert Malafosse, Jacques Sellier, Catherine Julie, Alain Beauchet, Bernard Nordlinger, Frédérique Peschaud
BACKGROUND: Radiofrequency ablation (RFA) is a valid treatment for liver metastases from colorectal cancer (CRLM) smaller than 25 mm and unsuitable for surgical resection. Tumor size is predictive for local tumor progression (LTP). The aim of this study was to evaluate whether RFA is indicated for lesions >25 mm at presentation but <25 mm after chemotherapy. METHOD: Patients who underwent RFA for CRLM after chemotherapy (January 2004-December 2012) were reviewed...
October 10, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29024719/calcification-or-not-this-is-the-question-a-one-year-study-of-bovine-pericardial-vascular-patches-cardiocel%C3%A2-in-minipigs
#19
Aida Salameh, Wiebke Greimann, David Vondrys, Martin Kostelka
Objectives A main problem with bioprosthesis used for surgical correction of congenital cardiac malformation is their tendency to shrink and to calcify. Recently, a new material i.e. de-cellularised bovine pericardium (CardioCel(®)) was introduced in clinics. It was proposed that this new patch material should not calcify and should be particularly suitable for the correction of vascular defects in inborn cardiac diseases. The aim of our chronic minipig study was to evaluate the performance of CardioCel(®) patches implanted in aortic and pulmonary artery position, respectively...
October 9, 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29023733/tonic-inhibition-of-brown-adipose-tissue-sympathetic-nerve-activity-via-muscarinic-acetylcholine-receptors-in-the-rostral-raphe-pallidus
#20
Ellen Paula Santos da Conceição, Christopher J Madden, Shaun F Morrison
We sought to determine if body temperature and energy expenditure are influenced by a cholinergic input to neurons in the rostral raphe pallidus (rRPa), the site of sympathetic premotor neurons controlling brown adipose tissue (BAT) thermogenesis. Nanoinjections of the muscarinic acetylcholine receptor (mAChR) receptor agonist, oxotremorine, or the cholinesterase inhibitor, neostigmine (NEOS), in the rRPa of anaesthetized rats decreased cold-evoked BAT sympathetic nerve activity (SNA, nadirs: -72%, and -95%), BAT temperature (TBAT, -0...
October 10, 2017: Journal of Physiology
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