Karan Goswami, Samuel Clarkson, Caleb D Phillips, Douglas A Dennis, Brian A Klatt, Michael J O'Malley, Eric L Smith, Jeremy M Gililland, Christopher E Pelt, Christopher L Peters, Arthur L Malkani, Brian T Palumbo, Steven T Lyons, Thomas L Bernasek, Jon Minter, Nitin Goyal, James F McDonald, Michael B Cross, Hernan A Prieto, Gwo-Chin Lee, Erik N Hansen, Stefano A Bini, Derek T Ward, Noam Shohat, Carlos A Higuera, Dennis Nam, Craig J Della Valle, Javad Parvizi
BACKGROUND: The challenges of culture-negative periprosthetic joint infection (PJI) have led to the emergence of molecular methods of pathogen identification, including next-generation sequencing (NGS). While its increased sensitivity compared with traditional culture techniques is well documented, it is not fully known which organisms could be expected to be detected with use of NGS. The aim of this study was to describe the NGS profile of culture-negative PJI. METHODS: Patients undergoing revision hip or knee arthroplasty from June 2016 to August 2020 at 14 institutions were prospectively recruited...
September 7, 2022: Journal of Bone and Joint Surgery. American Volume