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METTL21

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https://www.readbyqxmd.com/read/26115316/saccharomyces-cerevisiae-eukaryotic-elongation-factor-1a-eef1a-is-methylated-at-lys-390-by-a-mettl21-like-methyltransferase
#1
Magnus E Jakobsson, Erna Davydova, Jędrzej Małecki, Anders Moen, Pål Ø Falnes
The human methyltransferases (MTases) METTL21A and VCP-KMT (METTL21D) were recently shown to methylate single lysine residues in Hsp70 proteins and in VCP, respectively. The yet uncharacterized MTase encoded by the YNL024C gene in Saccharomyces cerevisiae shows high sequence similarity to METTL21A and VCP-KMT, as well as to their uncharacterized paralogues METTL21B and METTL21C. Despite being most similar to METTL21A, the Ynl024c protein does not methylate yeast Hsp70 proteins, which were found to be unmethylated on the relevant lysine residue...
2015: PloS One
https://www.readbyqxmd.com/read/24677265/mettl21c-is-a-potential-pleiotropic-gene-for-osteoporosis-and-sarcopenia-acting-through-the-modulation-of-the-nf-%C3%AE%C2%BAb-signaling-pathway
#2
Jian Huang, Yi-Hsiang Hsu, Chenglin Mo, Eduardo Abreu, Douglas P Kiel, Lynda F Bonewald, Marco Brotto, David Karasik
Sarcopenia and osteoporosis are important public health problems that occur concurrently. A bivariate genome-wide association study (GWAS) identified METTL21c as a suggestive pleiotropic gene for both bone and muscle. The METTL21 family of proteins methylates chaperones involved in the etiology of both myopathy and inclusion body myositis with Paget's disease. To validate these GWAS results, Mettl21c mRNA expression was reduced with siRNA in a mouse myogenic C2C12 cell line and the mouse osteocyte-like cell line MLO-Y4...
July 2014: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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